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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:STRN-SULT6B1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: STRN-SULT6B1
	FusionPDB ID: 87741
	FusionGDB2.0 ID: 87741
		Hgene	Tgene
	Gene symbol	STRN	SULT6B1
	Gene ID	6801	391365
	Gene name	striatin	sulfotransferase family 6B member 1
	Synonyms	PPP2R6A\|SG2NA\|STRN1	ST6B1
	Cytomap	2p22.2	2p22.2
	Type of gene	protein-coding	protein-coding
	Description	striatinprotein phosphatase 2 regulatory subunit B'''alphastriatin, calmodulin binding protein	sulfotransferase 6B1sulfotransferase SULT6B1sulfotransferase family, cytosolic, 6B, member 1thyroxine sulfotransferase
	Modification date	20200313	20200313
	UniProtAcc	O43815	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000263918, ENST00000379213,	ENST00000407963, ENST00000260637, ENST00000379149, ENST00000535679,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 14 X 10=1400	1 X 1 X 1=1
	# samples	15	1
	** MAII score	log2(15/1400*10)=-3.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)	PubMed: STRN [Title/Abstract] AND SULT6B1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	STRN(37126666)-SULT6B1(37415690), # samples:3
Anticipated loss of major functional domain due to fusion event.	STRN-SULT6B1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. STRN-SULT6B1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across STRN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SULT6B1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-NI-A4U2-01A	STRN	chr2	37126666	-	SULT6B1	chr2	37415690	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000263918	STRN	chr2	37126666	-	ENST00000260637	SULT6B1	chr2	37415690	-	1738	804	9	1622	537
ENST00000263918	STRN	chr2	37126666	-	ENST00000379149	SULT6B1	chr2	37415690	-	1426	804	9	881	290
ENST00000263918	STRN	chr2	37126666	-	ENST00000535679	SULT6B1	chr2	37415690	-	1738	804	9	881	290
ENST00000379213	STRN	chr2	37126666	-	ENST00000260637	SULT6B1	chr2	37415690	-	1693	759	0	1577	525
ENST00000379213	STRN	chr2	37126666	-	ENST00000379149	SULT6B1	chr2	37415690	-	1381	759	0	836	278
ENST00000379213	STRN	chr2	37126666	-	ENST00000535679	SULT6B1	chr2	37415690	-	1693	759	0	836	278

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000263918	ENST00000260637	STRN	chr2	37126666	-	SULT6B1	chr2	37415690	-	0.000530956	0.9994691
ENST00000263918	ENST00000379149	STRN	chr2	37126666	-	SULT6B1	chr2	37415690	-	0.000556654	0.99944335
ENST00000263918	ENST00000535679	STRN	chr2	37126666	-	SULT6B1	chr2	37415690	-	0.00048848	0.9995115
ENST00000379213	ENST00000260637	STRN	chr2	37126666	-	SULT6B1	chr2	37415690	-	0.000466129	0.9995339
ENST00000379213	ENST00000379149	STRN	chr2	37126666	-	SULT6B1	chr2	37415690	-	0.000575354	0.9994247
ENST00000379213	ENST00000535679	STRN	chr2	37126666	-	SULT6B1	chr2	37415690	-	0.000517537	0.9994824

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>87741_87741_1_STRN-SULT6B1_STRN_chr2_37126666_ENST00000263918_SULT6B1_chr2_37415690_ENST00000260637_length(amino acids)=537AA_BP=265
MDEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKG
QENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKS
KRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTGIPYP
ITMCTSETFQALDTFEARHDDIVLASYPKCGSNWILHIVSELIYAVSKKKYKYPEFPVLECGDSEKYQRMKGFPSPRILATHLHYDKLPG
SIFENKAKILVIFRNPKDTAVSFLHFHNDVPDIPSYGSWDEFFRQFMKGQVSWGRYFDFAINWNKHLDGDNVKFILYEDLKENLAAGIKQ

--------------------------------------------------------------

>87741_87741_2_STRN-SULT6B1_STRN_chr2_37126666_ENST00000263918_SULT6B1_chr2_37415690_ENST00000379149_length(amino acids)=290AA_BP=
MDEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKG
QENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKS
KRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTVKLVI

--------------------------------------------------------------

>87741_87741_3_STRN-SULT6B1_STRN_chr2_37126666_ENST00000263918_SULT6B1_chr2_37415690_ENST00000535679_length(amino acids)=290AA_BP=
MDEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKG
QENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKS
KRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTVKLVI

--------------------------------------------------------------

>87741_87741_4_STRN-SULT6B1_STRN_chr2_37126666_ENST00000379213_SULT6B1_chr2_37415690_ENST00000260637_length(amino acids)=525AA_BP=253
MDEQAGPGVFFSNNHPGAGGAKGLGPLAGAARAQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRI
KMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSD
VTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTGIPYPITMCTSETFQAL
DTFEARHDDIVLASYPKCGSNWILHIVSELIYAVSKKKYKYPEFPVLECGDSEKYQRMKGFPSPRILATHLHYDKLPGSIFENKAKILVI
FRNPKDTAVSFLHFHNDVPDIPSYGSWDEFFRQFMKGQVSWGRYFDFAINWNKHLDGDNVKFILYEDLKENLAAGIKQIAEFLGFFLTGE

--------------------------------------------------------------

>87741_87741_5_STRN-SULT6B1_STRN_chr2_37126666_ENST00000379213_SULT6B1_chr2_37415690_ENST00000379149_length(amino acids)=278AA_BP=
MDEQAGPGVFFSNNHPGAGGAKGLGPLAGAARAQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRI
KMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSD
VTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTVKLVIGKICSVKFRTRK

--------------------------------------------------------------

>87741_87741_6_STRN-SULT6B1_STRN_chr2_37126666_ENST00000379213_SULT6B1_chr2_37415690_ENST00000535679_length(amino acids)=278AA_BP=
MDEQAGPGVFFSNNHPGAGGAKGLGPLAGAARAQYSLPGILHFLQHEWARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRI
KMLEYALKQERAKYHKLKYGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVRALLGFSSD
VTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTVKLVIGKICSVKFRTRK

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:37126666/chr2:37415690)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
STRN O43815	.
FUNCTION: Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STRN

chr2:37126666

chr2:37415690

ENST00000263918

53_120

265.0

781.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

STRN

chr2:37126666

chr2:37415690

ENST00000379213

53_120

253.0

732.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

STRN

chr2:37126666

chr2:37415690

ENST00000263918

149_166

265.0

781.0

Region

Calmodulin-binding

Hgene

STRN

chr2:37126666

chr2:37415690

ENST00000263918

55_63

265.0

781.0

Region

Caveolin-binding

Hgene

STRN

chr2:37126666

chr2:37415690

ENST00000379213

149_166

253.0

732.0

Region

Calmodulin-binding

Hgene

STRN

chr2:37126666

chr2:37415690

ENST00000379213

55_63

253.0

732.0

Region

Caveolin-binding

Tgene

SULT6B1

chr2:37126666

chr2:37415690

ENST00000260637

-1

237_242

28.333333333333332

266.0

Nucleotide binding

PAPS

Tgene

SULT6B1

chr2:37126666

chr2:37415690

ENST00000260637

-1

259_261

28.333333333333332

266.0

Nucleotide binding

PAPS

Tgene

SULT6B1

chr2:37126666

chr2:37415690

ENST00000260637

-1

65_70

28.333333333333332

266.0

Nucleotide binding

PAPS

Tgene

SULT6B1

chr2:37126666

chr2:37415690

ENST00000379149

237_242

0.0

200.0

Nucleotide binding

PAPS

Tgene

SULT6B1

chr2:37126666

chr2:37415690

ENST00000379149

259_261

0.0

200.0

Nucleotide binding

PAPS

Tgene

SULT6B1

chr2:37126666

chr2:37415690

ENST00000379149

65_70

0.0

200.0

Nucleotide binding

PAPS

Tgene

SULT6B1

chr2:37126666

chr2:37415690

ENST00000407963

237_242

266.0

Nucleotide binding

PAPS

Tgene

SULT6B1

chr2:37126666

chr2:37415690

ENST00000407963

259_261

266.0

Nucleotide binding

PAPS

Tgene

SULT6B1

chr2:37126666

chr2:37415690

ENST00000407963

65_70

266.0

Nucleotide binding

PAPS

Tgene

SULT6B1

chr2:37126666

chr2:37415690

ENST00000535679

237_242

0.0

304.0

Nucleotide binding

PAPS

Tgene

SULT6B1

chr2:37126666

chr2:37415690

ENST00000535679

259_261

0.0

304.0

Nucleotide binding

PAPS

Tgene

SULT6B1

chr2:37126666

chr2:37415690

ENST00000535679

65_70

0.0

304.0

Nucleotide binding

PAPS

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STRN

chr2:37126666

chr2:37415690

ENST00000263918

461_500

265.0

781.0

Repeat

Note=WD 1

Hgene

STRN

chr2:37126666

chr2:37415690

ENST00000263918

514_553

265.0

781.0

Repeat

Note=WD 2

Hgene

STRN

chr2:37126666

chr2:37415690

ENST00000263918

567_606

265.0

781.0

Repeat

Note=WD 3

Hgene

STRN

chr2:37126666

chr2:37415690

ENST00000263918

662_701

265.0

781.0

Repeat

Note=WD 4

Hgene

STRN

chr2:37126666

chr2:37415690

ENST00000263918

704_743

265.0

781.0

Repeat

Note=WD 5

Hgene

STRN

chr2:37126666

chr2:37415690

ENST00000263918

750_779

265.0

781.0

Repeat

Note=WD 6

Hgene

STRN

chr2:37126666

chr2:37415690

ENST00000379213

461_500

253.0

732.0

Repeat

Note=WD 1

Hgene

STRN

chr2:37126666

chr2:37415690

ENST00000379213

514_553

253.0

732.0

Repeat

Note=WD 2

Hgene

STRN

chr2:37126666

chr2:37415690

ENST00000379213

567_606

253.0

732.0

Repeat

Note=WD 3

Hgene

STRN

chr2:37126666

chr2:37415690

ENST00000379213

662_701

253.0

732.0

Repeat

Note=WD 4

Hgene

STRN

chr2:37126666

chr2:37415690

ENST00000379213

704_743

253.0

732.0

Repeat

Note=WD 5

Hgene

STRN

chr2:37126666

chr2:37415690

ENST00000379213

750_779

253.0

732.0

Repeat

Note=WD 6

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

STRN

STK24, MCC, CTTNBP2, CTTNBP2NL, STRIP1, MOB4, PDCD10, PPP2CA, PPP2R1A, STK26, SIKE1, STK25, STRN3, PPP2R1B, STRN4, STRIP2, SLMAP, CCT2, CCT8, CCT3, TCP1, CCT5, FGFR1OP2, CCT6A, CCT7, CCT4, CCT6B, TRAF3IP3, PPP2CB, ZRANB1, Dynll1, ELAVL1, LNX1, APC, TJP1, DDX1, DYNC1H1, CPSF6, EIF2S1, SF3B5, BRCA1, ECT2, PAXIP1, STK3, STK4, TFIP11, RINT1, PCOLCE2, LYPD3, NR1H3, PPP2R2C, RASSF3, PGAM5, NTRK1, HSPB1, DYNLL1, MAP4K4, EEF1E1, BAG2, SLC43A3, AHNAK, Ppp2ca, Ppp2r1a, Strn3, Arrb2, Strip1, PRDM14, TNFRSF1A, NHSL2, PSMC5, PLP1, ZNF550, SNX24, LRRCC1, ZNF331, PRPF19, SPINK2, EXOC1, PKN3, NCKAP5L, TFPT, CCHCR1, YEATS4, TUFT1, RABGAP1L, GOLGA5, GIPC1, ESR2, USP15, GOLGA2, KIAA1429, ATG16L1, HOOK3, EP300, ESR1, RMDN3, CUL4A, TULP3, GOLGA1, TMOD1, MINK1, TNIK, SMAD4, DYNLL2, PMF1, RABEP2, ENDOD1, FLII, KIAA1522, GOLGA8G, ISCA2, GOLGA6A, FILIP1, SSUH2, PCM1, CAMK2B, MAP1S,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
STRN
SULT6B1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to STRN-SULT6B1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to STRN-SULT6B1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source