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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:B4GALT7-NSD1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: B4GALT7-NSD1
FusionPDB ID: 8783
FusionGDB2.0 ID: 8783
HgeneTgene
Gene symbol

B4GALT7

NSD1

Gene ID

11285

64324

Gene namebeta-1,4-galactosyltransferase 7nuclear receptor binding SET domain protein 1
SynonymsEDSP1|EDSSLA|EDSSPD1|XGALT1|XGPT|XGPT1ARA267|KMT3B|SOTOS|SOTOS1|STO
Cytomap

5q35.3

5q35.3

Type of geneprotein-codingprotein-coding
Descriptionbeta-1,4-galactosyltransferase 7UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7UDP-galactose:beta-xylose beta-1,4-galactosyltransferasebeta-1,4-GalTase 7beta-1,4-galactosyltrhistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificH3-K36-HMTaseH4-K20-HMTaseNR-binding SET domain-containing proteinandrogen receptor coactivator 267 kDa proteinandrogen receptor-associated coregulator 267androgen receptor-as
Modification date2020031320200321
UniProtAcc

Q9UBV7

.
Ensembl transtripts involved in fusion geneENST idsENST00000029410, ENST00000361032, 
ENST00000511258, ENST00000347982, 
ENST00000354179, ENST00000439151, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score1 X 3 X 2=612 X 14 X 7=1176
# samples 217
** MAII scorelog2(2/6*10)=1.73696559416621log2(17/1176*10)=-2.79028140869866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: B4GALT7 [Title/Abstract] AND NSD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)B4GALT7(177035623)-NSD1(176618885), # samples:3
B4GALT7(177027261)-NSD1(176665238), # samples:3
Anticipated loss of major functional domain due to fusion event.B4GALT7-NSD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
B4GALT7-NSD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
B4GALT7-NSD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
B4GALT7-NSD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
B4GALT7-NSD1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
B4GALT7-NSD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
B4GALT7-NSD1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
B4GALT7-NSD1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
B4GALT7-NSD1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
B4GALT7-NSD1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneB4GALT7

GO:0006024

glycosaminoglycan biosynthetic process

10438455

HgeneB4GALT7

GO:0006487

protein N-linked glycosylation

24052259

TgeneNSD1

GO:0045893

positive regulation of transcription, DNA-templated

11509567


check buttonFusion gene breakpoints across B4GALT7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NSD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A12F-01AB4GALT7chr5

177034528

+NSD1chr5

176618885

+
ChimerDB4BRCATCGA-AO-A12F-01AB4GALT7chr5

177035623

-NSD1chr5

176618885

+
ChimerDB4BRCATCGA-AO-A12F-01AB4GALT7chr5

177035623

+NSD1chr5

176618885

+
ChimerDB4UCSTCGA-N6-A4VC-01AB4GALT7chr5

177027261

-NSD1chr5

176665238

+
ChimerDB4UCSTCGA-N6-A4VC-01AB4GALT7chr5

177027261

+NSD1chr5

176665238

+
ChimerDB4UCSTCGA-N6-A4VCB4GALT7chr5

177027261

+NSD1chr5

176665238

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000029410B4GALT7chr5177035623+ENST00000354179NSD1chr5176618885+127498348179972638
ENST00000029410B4GALT7chr5177035623+ENST00000439151NSD1chr5176618885+127548348179972638
ENST00000029410B4GALT7chr5177035623+ENST00000347982NSD1chr5176618885+83018348179972638
ENST00000029410B4GALT7chr5177034528+ENST00000354179NSD1chr5176618885+126657508179132610
ENST00000029410B4GALT7chr5177034528+ENST00000439151NSD1chr5176618885+126707508179132610
ENST00000029410B4GALT7chr5177034528+ENST00000347982NSD1chr5176618885+82177508179132610

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000029410ENST00000354179B4GALT7chr5177035623+NSD1chr5176618885+0.0002643580.99973565
ENST00000029410ENST00000439151B4GALT7chr5177035623+NSD1chr5176618885+0.0002642780.99973565
ENST00000029410ENST00000347982B4GALT7chr5177035623+NSD1chr5176618885+0.0005061710.99949384
ENST00000029410ENST00000354179B4GALT7chr5177034528+NSD1chr5176618885+0.0002638920.99973613
ENST00000029410ENST00000439151B4GALT7chr5177034528+NSD1chr5176618885+0.0002638110.99973613
ENST00000029410ENST00000347982B4GALT7chr5177034528+NSD1chr5176618885+0.00050810.99949193

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>8783_8783_1_B4GALT7-NSD1_B4GALT7_chr5_177034528_ENST00000029410_NSD1_chr5_176618885_ENST00000347982_length(amino acids)=2610AA_BP=223
MPHAPPPLRTMFPSRRKAAQLPWEDGRSGLLSGGLPRKCSVFHLFVACLSLGFFSLLWLQLSCSGDVARAVRGQGQETSGPPRACPPEPP
PEHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRHHIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLN
EELDYGFPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVS
NRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGS
IKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLN
FISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGA
GDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCT
KSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVI
NEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQ
NHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSA
LSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGG
SLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQR
RTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSL
TPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLE
REAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCY
EAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMP
ASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYH
EECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVN
VSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPV
LFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT
ADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELI
DEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNG
KTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGK
WECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQ
APKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPV
TSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLS
AVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTS
GKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKA
PASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK

--------------------------------------------------------------

>8783_8783_2_B4GALT7-NSD1_B4GALT7_chr5_177034528_ENST00000029410_NSD1_chr5_176618885_ENST00000354179_length(amino acids)=2610AA_BP=223
MPHAPPPLRTMFPSRRKAAQLPWEDGRSGLLSGGLPRKCSVFHLFVACLSLGFFSLLWLQLSCSGDVARAVRGQGQETSGPPRACPPEPP
PEHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRHHIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLN
EELDYGFPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVS
NRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGS
IKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLN
FISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGA
GDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCT
KSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVI
NEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQ
NHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSA
LSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGG
SLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQR
RTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSL
TPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLE
REAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCY
EAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMP
ASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYH
EECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVN
VSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPV
LFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT
ADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELI
DEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNG
KTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGK
WECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQ
APKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPV
TSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLS
AVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTS
GKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKA
PASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK

--------------------------------------------------------------

>8783_8783_3_B4GALT7-NSD1_B4GALT7_chr5_177034528_ENST00000029410_NSD1_chr5_176618885_ENST00000439151_length(amino acids)=2610AA_BP=223
MPHAPPPLRTMFPSRRKAAQLPWEDGRSGLLSGGLPRKCSVFHLFVACLSLGFFSLLWLQLSCSGDVARAVRGQGQETSGPPRACPPEPP
PEHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRHHIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLN
EELDYGFPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCQPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVS
NRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKILSKWEASVGLAEQYDVPKGSKNRKCIPGS
IKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKRTSVKKGHIQFEAHKDERRGKIPENLGLN
FISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGALISKCSREKNKPQRSLVCGSKVKLCYIGA
GDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSRFAATNTRVKAKQKPLISNSHTDHLMGCT
KSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALLHSKSKQPKFRSIKCKHKENPVMAEPPVI
NEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLGEDVSDSGTSKPSKPLLFSSASSQ
NHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVSGGSTHNSEKKGDGTQNSANPSPSGGDSA
LSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKALKTERKRKLNQLPSVTLDAVLQGDRERGG
SLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELDSVMNSENDELNGVNQVVPKKRWQRLNQR
RTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLDSAGPRLNVCDKSSASIGDMEKEPGIPSL
TPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLLARGRSSAQNKQVDENSLISTKEEPPVLE
REAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKPTKKLLESNDLDPGFMPKKGDLGLSKKCY
EAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGSEGELMPHRTATSPKETVEEGVEHDPGMP
ASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYH
EECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVN
VSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPV
LFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFT
ADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELI
DEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNG
KTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAGQLVSCKKPGCPKVYHADCLNLTKRPAGK
WECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPPVPLPPGPSTHLAEQSTGMAAQ
APKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPV
TSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQTSDRPTDKPHASLSQRLPPPEKVLS
AVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLESSSWPASKGLGHMPRAVEKGCVSDPLQTS
GKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVKQAKQMVGGQQLPALAAKSGQSFRSLGKA
PASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGRGQDPKPEQNTLPALNQAPSSHKCAESEQK

--------------------------------------------------------------

>8783_8783_4_B4GALT7-NSD1_B4GALT7_chr5_177035623_ENST00000029410_NSD1_chr5_176618885_ENST00000347982_length(amino acids)=2638AA_BP=249
MPHAPPPLRTMFPSRRKAAQLPWEDGRSGLLSGGLPRKCSVFHLFVACLSLGFFSLLWLQLSCSGDVARAVRGQGQETSGPPRACPPEPP
PEHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRHHIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLN
EELDYGFPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCNGMSNRFWGWGREDDEFYRRIKGAGLQCQPKKKSTPLKYEVGDLIW
AKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKIL
SKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKR
TSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGAL
ISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSR
FAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALL
HSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELS
YRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVS
GGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKAL
KTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELD
SVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLD
SAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLL
ARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKP
TKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGS
EGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRT
GIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAG
SKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYR
WWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQ
EDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFR
TLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDT
RVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAG
QLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEI
REYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQS
LVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSP
KPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLES
SSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVK
QAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGRG

--------------------------------------------------------------

>8783_8783_5_B4GALT7-NSD1_B4GALT7_chr5_177035623_ENST00000029410_NSD1_chr5_176618885_ENST00000354179_length(amino acids)=2638AA_BP=249
MPHAPPPLRTMFPSRRKAAQLPWEDGRSGLLSGGLPRKCSVFHLFVACLSLGFFSLLWLQLSCSGDVARAVRGQGQETSGPPRACPPEPP
PEHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRHHIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLN
EELDYGFPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCNGMSNRFWGWGREDDEFYRRIKGAGLQCQPKKKSTPLKYEVGDLIW
AKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKIL
SKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKR
TSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGAL
ISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSR
FAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALL
HSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELS
YRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVS
GGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKAL
KTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELD
SVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLD
SAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLL
ARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKP
TKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGS
EGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRT
GIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAG
SKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYR
WWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQ
EDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFR
TLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDT
RVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAG
QLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEI
REYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQS
LVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSP
KPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLES
SSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVK
QAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGRG

--------------------------------------------------------------

>8783_8783_6_B4GALT7-NSD1_B4GALT7_chr5_177035623_ENST00000029410_NSD1_chr5_176618885_ENST00000439151_length(amino acids)=2638AA_BP=249
MPHAPPPLRTMFPSRRKAAQLPWEDGRSGLLSGGLPRKCSVFHLFVACLSLGFFSLLWLQLSCSGDVARAVRGQGQETSGPPRACPPEPP
PEHWEEDASWGPHRLAVLVPFRERFEELLVFVPHMRRFLSRKKIRHHIYVLNQVDHFRFNRAALINVGFLESSNSTDYIAMHDVDLLPLN
EELDYGFPEAGPFHVASPELHPLYHYKTYVGGILLLSKQHYRLCNGMSNRFWGWGREDDEFYRRIKGAGLQCQPKKKSTPLKYEVGDLIW
AKFKRRPWWPCRICSDPLINTHSKMKVSNRRPYRQYYVEAFGDPSERAWVAGKAIVMFEGRHQFEELPVLRRRGKQKEKGYRHKVPQKIL
SKWEASVGLAEQYDVPKGSKNRKCIPGSIKLDSEEDMPFEDCTNDPESEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRARKSSDNPKR
TSVKKGHIQFEAHKDERRGKIPENLGLNFISGDISDTQASNELSRIANSLTGSNTAPGSFLFSSCGKNTAKKEFETSNGDSLLGLPEGAL
ISKCSREKNKPQRSLVCGSKVKLCYIGAGDEEKRSDSISICTTSDDGSSDLDPIEHSSESDNSVLEIPDAFDRTENMLSMQKNEKIKYSR
FAATNTRVKAKQKPLISNSHTDHLMGCTKSAEPGTETSQVNLSDLKASTLVHKPQSDFTNDALSPKFNLSSSISSENSLIKGGAANQALL
HSKSKQPKFRSIKCKHKENPVMAEPPVINEECSLKCCSSDTKGSPLASISKSGKVDGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELS
YRSLGEDVSDSGTSKPSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNLVSYRSPGRGDCSTNSPVGVSKVLVS
GGSTHNSEKKGDGTQNSANPSPSGGDSALSGELSASLPGLLSDKRDLPASGKSRSDCVTRRNCGRSKPSSKLRDAFSAQMVKNTVNRKAL
KTERKRKLNQLPSVTLDAVLQGDRERGGSLRGGAEDPSKEDPLQIMGHLTSEDGDHFSDVHFDSKVKQSDPGKISEKGLSFENGKGPELD
SVMNSENDELNGVNQVVPKKRWQRLNQRRTKPRKRMNRFKEKENSECAFRVLLPSDPVQEGRDEFPEHRTPSASILEEPLTEQNHADCLD
SAGPRLNVCDKSSASIGDMEKEPGIPSLTPQAELPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEEESLL
ARGRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLAQSELGGGHAELPQLTLSVPVAPEVSPRPALESEELLVKTPGNYESKRQRKP
TKKLLESNDLDPGFMPKKGDLGLSKKCYEAGHLENGITESCATSYSKDFGGGTTKIFDKPRKRKRQRHAAAKMQCKKVKNDDSSKEIPGS
EGELMPHRTATSPKETVEEGVEHDPGMPASKKMQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRT
GIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVMQNKGFRCSLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAG
SKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYR
WWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQ
EDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPEVEIFR
TLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDT
RVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIATEEKSKKFKKKQQGKRRTQGEITKEREDECFSCGDAG
QLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDICGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEI
REYVPPPVPLPPGPSTHLAEQSTGMAAQAPKMSDKPPADTNQMLSLSKKALAGTCQRPLLPERPLERTDSRPQPLDKVRDLAGSGTKSQS
LVSSQRPLDRPPAVAGPRPQLSDKPSPVTSPSSSPSVRSQPLERPLGTADPRLDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSP
KPQTSDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQSKNRAALVMDLIDLTPRQKERAASPHQVTPQADEKMPVLES
SSWPASKGLGHMPRAVEKGCVSDPLQTSGKAAAPSEDPWQAVKSLTQARLLSQPPAKAFLYEPTTQASGRASAGAEQTPGPLSQSPGLVK
QAKQMVGGQQLPALAAKSGQSFRSLGKAPASLPTEEKKLVTTEQSPWALGKASSRAGLWPIVAGQTLAQSCWSAGSTQTLAQTCWSLGRG

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:177035623/chr5:176618885)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
B4GALT7

Q9UBV7

.
FUNCTION: Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts. {ECO:0000269|PubMed:24052259}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneB4GALT7chr5:177034528chr5:176618885ENST00000029410+36100_104213.0328.0RegionUDP-alpha-D-galactose binding
HgeneB4GALT7chr5:177034528chr5:176618885ENST00000029410+36139_141213.0328.0RegionUDP-alpha-D-galactose binding
HgeneB4GALT7chr5:177034528chr5:176618885ENST00000029410+36164_165213.0328.0RegionUDP-alpha-D-galactose binding
HgeneB4GALT7chr5:177035623chr5:176618885ENST00000029410+46100_104241.0328.0RegionUDP-alpha-D-galactose binding
HgeneB4GALT7chr5:177035623chr5:176618885ENST00000029410+46139_141241.0328.0RegionUDP-alpha-D-galactose binding
HgeneB4GALT7chr5:177035623chr5:176618885ENST00000029410+46164_165241.0328.0RegionUDP-alpha-D-galactose binding
HgeneB4GALT7chr5:177035623chr5:176618885ENST00000029410+46226_229241.0328.0RegionN-acetyl-D-glucosamine binding
HgeneB4GALT7chr5:177034528chr5:176618885ENST00000029410+361_30213.0328.0Topological domainCytoplasmic
HgeneB4GALT7chr5:177035623chr5:176618885ENST00000029410+461_30241.0328.0Topological domainCytoplasmic
HgeneB4GALT7chr5:177034528chr5:176618885ENST00000029410+3631_51213.0328.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneB4GALT7chr5:177035623chr5:176618885ENST00000029410+4631_51241.0328.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneNSD1chr5:177034528chr5:176618885ENST000003479822242207_242140.02428.0Compositional biasNote=Pro-rich
TgeneNSD1chr5:177034528chr5:176618885ENST000003541792242207_242140.02428.0Compositional biasNote=Pro-rich
TgeneNSD1chr5:177034528chr5:176618885ENST000003610320202207_24210.02594.0Compositional biasNote=Pro-rich
TgeneNSD1chr5:177034528chr5:176618885ENST000004391511232207_2421309.02697.0Compositional biasNote=Pro-rich
TgeneNSD1chr5:177035623chr5:176618885ENST000003479822242207_242140.02428.0Compositional biasNote=Pro-rich
TgeneNSD1chr5:177035623chr5:176618885ENST000003541792242207_242140.02428.0Compositional biasNote=Pro-rich
TgeneNSD1chr5:177035623chr5:176618885ENST000003610320202207_24210.02594.0Compositional biasNote=Pro-rich
TgeneNSD1chr5:177035623chr5:176618885ENST000004391511232207_2421309.02697.0Compositional biasNote=Pro-rich
TgeneNSD1chr5:177034528chr5:176618885ENST000003479822241756_181840.02428.0DomainPWWP 2
TgeneNSD1chr5:177034528chr5:176618885ENST000003479822241890_194040.02428.0DomainAWS
TgeneNSD1chr5:177034528chr5:176618885ENST000003479822241942_205940.02428.0DomainSET
TgeneNSD1chr5:177034528chr5:176618885ENST000003479822242066_208240.02428.0DomainPost-SET
TgeneNSD1chr5:177034528chr5:176618885ENST00000347982224323_38840.02428.0DomainPWWP 1
TgeneNSD1chr5:177034528chr5:176618885ENST000003541792241756_181840.02428.0DomainPWWP 2
TgeneNSD1chr5:177034528chr5:176618885ENST000003541792241890_194040.02428.0DomainAWS
TgeneNSD1chr5:177034528chr5:176618885ENST000003541792241942_205940.02428.0DomainSET
TgeneNSD1chr5:177034528chr5:176618885ENST000003541792242066_208240.02428.0DomainPost-SET
TgeneNSD1chr5:177034528chr5:176618885ENST00000354179224323_38840.02428.0DomainPWWP 1
TgeneNSD1chr5:177034528chr5:176618885ENST000003610320201756_18180.02594.0DomainPWWP 2
TgeneNSD1chr5:177034528chr5:176618885ENST000003610320201890_19400.02594.0DomainAWS
TgeneNSD1chr5:177034528chr5:176618885ENST000003610320201942_20590.02594.0DomainSET
TgeneNSD1chr5:177034528chr5:176618885ENST000003610320202066_20820.02594.0DomainPost-SET
TgeneNSD1chr5:177034528chr5:176618885ENST00000361032020323_3880.02594.0DomainPWWP 1
TgeneNSD1chr5:177034528chr5:176618885ENST000004391511231756_1818309.02697.0DomainPWWP 2
TgeneNSD1chr5:177034528chr5:176618885ENST000004391511231890_1940309.02697.0DomainAWS
TgeneNSD1chr5:177034528chr5:176618885ENST000004391511231942_2059309.02697.0DomainSET
TgeneNSD1chr5:177034528chr5:176618885ENST000004391511232066_2082309.02697.0DomainPost-SET
TgeneNSD1chr5:177034528chr5:176618885ENST00000439151123323_388309.02697.0DomainPWWP 1
TgeneNSD1chr5:177035623chr5:176618885ENST000003479822241756_181840.02428.0DomainPWWP 2
TgeneNSD1chr5:177035623chr5:176618885ENST000003479822241890_194040.02428.0DomainAWS
TgeneNSD1chr5:177035623chr5:176618885ENST000003479822241942_205940.02428.0DomainSET
TgeneNSD1chr5:177035623chr5:176618885ENST000003479822242066_208240.02428.0DomainPost-SET
TgeneNSD1chr5:177035623chr5:176618885ENST00000347982224323_38840.02428.0DomainPWWP 1
TgeneNSD1chr5:177035623chr5:176618885ENST000003541792241756_181840.02428.0DomainPWWP 2
TgeneNSD1chr5:177035623chr5:176618885ENST000003541792241890_194040.02428.0DomainAWS
TgeneNSD1chr5:177035623chr5:176618885ENST000003541792241942_205940.02428.0DomainSET
TgeneNSD1chr5:177035623chr5:176618885ENST000003541792242066_208240.02428.0DomainPost-SET
TgeneNSD1chr5:177035623chr5:176618885ENST00000354179224323_38840.02428.0DomainPWWP 1
TgeneNSD1chr5:177035623chr5:176618885ENST000003610320201756_18180.02594.0DomainPWWP 2
TgeneNSD1chr5:177035623chr5:176618885ENST000003610320201890_19400.02594.0DomainAWS
TgeneNSD1chr5:177035623chr5:176618885ENST000003610320201942_20590.02594.0DomainSET
TgeneNSD1chr5:177035623chr5:176618885ENST000003610320202066_20820.02594.0DomainPost-SET
TgeneNSD1chr5:177035623chr5:176618885ENST00000361032020323_3880.02594.0DomainPWWP 1
TgeneNSD1chr5:177035623chr5:176618885ENST000004391511231756_1818309.02697.0DomainPWWP 2
TgeneNSD1chr5:177035623chr5:176618885ENST000004391511231890_1940309.02697.0DomainAWS
TgeneNSD1chr5:177035623chr5:176618885ENST000004391511231942_2059309.02697.0DomainSET
TgeneNSD1chr5:177035623chr5:176618885ENST000004391511232066_2082309.02697.0DomainPost-SET
TgeneNSD1chr5:177035623chr5:176618885ENST00000439151123323_388309.02697.0DomainPWWP 1
TgeneNSD1chr5:177034528chr5:176618885ENST000003479822241952_195440.02428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177034528chr5:176618885ENST000003479822241994_199740.02428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177034528chr5:176618885ENST000003479822242020_202140.02428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177034528chr5:176618885ENST000003479822242060_206640.02428.0RegionNote=Inhibits enzyme activity in the absence of bound histone
TgeneNSD1chr5:177034528chr5:176618885ENST000003541792241952_195440.02428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177034528chr5:176618885ENST000003541792241994_199740.02428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177034528chr5:176618885ENST000003541792242020_202140.02428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177034528chr5:176618885ENST000003541792242060_206640.02428.0RegionNote=Inhibits enzyme activity in the absence of bound histone
TgeneNSD1chr5:177034528chr5:176618885ENST000003610320201952_19540.02594.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177034528chr5:176618885ENST000003610320201994_19970.02594.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177034528chr5:176618885ENST000003610320202020_20210.02594.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177034528chr5:176618885ENST000003610320202060_20660.02594.0RegionNote=Inhibits enzyme activity in the absence of bound histone
TgeneNSD1chr5:177034528chr5:176618885ENST000004391511231952_1954309.02697.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177034528chr5:176618885ENST000004391511231994_1997309.02697.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177034528chr5:176618885ENST000004391511232020_2021309.02697.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177034528chr5:176618885ENST000004391511232060_2066309.02697.0RegionNote=Inhibits enzyme activity in the absence of bound histone
TgeneNSD1chr5:177035623chr5:176618885ENST000003479822241952_195440.02428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177035623chr5:176618885ENST000003479822241994_199740.02428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177035623chr5:176618885ENST000003479822242020_202140.02428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177035623chr5:176618885ENST000003479822242060_206640.02428.0RegionNote=Inhibits enzyme activity in the absence of bound histone
TgeneNSD1chr5:177035623chr5:176618885ENST000003541792241952_195440.02428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177035623chr5:176618885ENST000003541792241994_199740.02428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177035623chr5:176618885ENST000003541792242020_202140.02428.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177035623chr5:176618885ENST000003541792242060_206640.02428.0RegionNote=Inhibits enzyme activity in the absence of bound histone
TgeneNSD1chr5:177035623chr5:176618885ENST000003610320201952_19540.02594.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177035623chr5:176618885ENST000003610320201994_19970.02594.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177035623chr5:176618885ENST000003610320202020_20210.02594.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177035623chr5:176618885ENST000003610320202060_20660.02594.0RegionNote=Inhibits enzyme activity in the absence of bound histone
TgeneNSD1chr5:177035623chr5:176618885ENST000004391511231952_1954309.02697.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177035623chr5:176618885ENST000004391511231994_1997309.02697.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177035623chr5:176618885ENST000004391511232020_2021309.02697.0RegionNote=S-adenosyl-L-methionine binding
TgeneNSD1chr5:177035623chr5:176618885ENST000004391511232060_2066309.02697.0RegionNote=Inhibits enzyme activity in the absence of bound histone
TgeneNSD1chr5:177034528chr5:176618885ENST000003479822241543_158940.02428.0Zinc fingerPHD-type 1
TgeneNSD1chr5:177034528chr5:176618885ENST000003479822241590_164640.02428.0Zinc fingerPHD-type 2
TgeneNSD1chr5:177034528chr5:176618885ENST000003479822241707_175140.02428.0Zinc fingerPHD-type 3
TgeneNSD1chr5:177034528chr5:176618885ENST000003479822242118_216540.02428.0Zinc fingerPHD-type 4%3B atypical
TgeneNSD1chr5:177034528chr5:176618885ENST000003541792241543_158940.02428.0Zinc fingerPHD-type 1
TgeneNSD1chr5:177034528chr5:176618885ENST000003541792241590_164640.02428.0Zinc fingerPHD-type 2
TgeneNSD1chr5:177034528chr5:176618885ENST000003541792241707_175140.02428.0Zinc fingerPHD-type 3
TgeneNSD1chr5:177034528chr5:176618885ENST000003541792242118_216540.02428.0Zinc fingerPHD-type 4%3B atypical
TgeneNSD1chr5:177034528chr5:176618885ENST000003610320201543_15890.02594.0Zinc fingerPHD-type 1
TgeneNSD1chr5:177034528chr5:176618885ENST000003610320201590_16460.02594.0Zinc fingerPHD-type 2
TgeneNSD1chr5:177034528chr5:176618885ENST000003610320201707_17510.02594.0Zinc fingerPHD-type 3
TgeneNSD1chr5:177034528chr5:176618885ENST000003610320202118_21650.02594.0Zinc fingerPHD-type 4%3B atypical
TgeneNSD1chr5:177034528chr5:176618885ENST000004391511231543_1589309.02697.0Zinc fingerPHD-type 1
TgeneNSD1chr5:177034528chr5:176618885ENST000004391511231590_1646309.02697.0Zinc fingerPHD-type 2
TgeneNSD1chr5:177034528chr5:176618885ENST000004391511231707_1751309.02697.0Zinc fingerPHD-type 3
TgeneNSD1chr5:177034528chr5:176618885ENST000004391511232118_2165309.02697.0Zinc fingerPHD-type 4%3B atypical
TgeneNSD1chr5:177035623chr5:176618885ENST000003479822241543_158940.02428.0Zinc fingerPHD-type 1
TgeneNSD1chr5:177035623chr5:176618885ENST000003479822241590_164640.02428.0Zinc fingerPHD-type 2
TgeneNSD1chr5:177035623chr5:176618885ENST000003479822241707_175140.02428.0Zinc fingerPHD-type 3
TgeneNSD1chr5:177035623chr5:176618885ENST000003479822242118_216540.02428.0Zinc fingerPHD-type 4%3B atypical
TgeneNSD1chr5:177035623chr5:176618885ENST000003541792241543_158940.02428.0Zinc fingerPHD-type 1
TgeneNSD1chr5:177035623chr5:176618885ENST000003541792241590_164640.02428.0Zinc fingerPHD-type 2
TgeneNSD1chr5:177035623chr5:176618885ENST000003541792241707_175140.02428.0Zinc fingerPHD-type 3
TgeneNSD1chr5:177035623chr5:176618885ENST000003541792242118_216540.02428.0Zinc fingerPHD-type 4%3B atypical
TgeneNSD1chr5:177035623chr5:176618885ENST000003610320201543_15890.02594.0Zinc fingerPHD-type 1
TgeneNSD1chr5:177035623chr5:176618885ENST000003610320201590_16460.02594.0Zinc fingerPHD-type 2
TgeneNSD1chr5:177035623chr5:176618885ENST000003610320201707_17510.02594.0Zinc fingerPHD-type 3
TgeneNSD1chr5:177035623chr5:176618885ENST000003610320202118_21650.02594.0Zinc fingerPHD-type 4%3B atypical
TgeneNSD1chr5:177035623chr5:176618885ENST000004391511231543_1589309.02697.0Zinc fingerPHD-type 1
TgeneNSD1chr5:177035623chr5:176618885ENST000004391511231590_1646309.02697.0Zinc fingerPHD-type 2
TgeneNSD1chr5:177035623chr5:176618885ENST000004391511231707_1751309.02697.0Zinc fingerPHD-type 3
TgeneNSD1chr5:177035623chr5:176618885ENST000004391511232118_2165309.02697.0Zinc fingerPHD-type 4%3B atypical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneB4GALT7chr5:177034528chr5:176618885ENST00000029410+36226_229213.0328.0RegionN-acetyl-D-glucosamine binding
HgeneB4GALT7chr5:177034528chr5:176618885ENST00000029410+36257_259213.0328.0RegionUDP-alpha-D-galactose binding
HgeneB4GALT7chr5:177035623chr5:176618885ENST00000029410+46257_259241.0328.0RegionUDP-alpha-D-galactose binding
HgeneB4GALT7chr5:177034528chr5:176618885ENST00000029410+3652_327213.0328.0Topological domainLumenal
HgeneB4GALT7chr5:177035623chr5:176618885ENST00000029410+4652_327241.0328.0Topological domainLumenal


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
B4GALT7
NSD1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to B4GALT7-NSD1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to B4GALT7-NSD1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource