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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SUZ12-TAC4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SUZ12-TAC4
FusionPDB ID: 88263
FusionGDB2.0 ID: 88263
HgeneTgene
Gene symbol

SUZ12

TAC4

Gene ID

23512

255061

Gene nameSUZ12 polycomb repressive complex 2 subunittachykinin precursor 4
SynonymsCHET9|IMMAS|JJAZ1EK|HK-1|HK1|PPT-C
Cytomap

17q11.2

17q21.33

Type of geneprotein-codingprotein-coding
Descriptionpolycomb protein SUZ12chET 9 proteinchromatin precipitated E2F target 9 proteinjoined to JAZF1 proteinsuppressor of zeste 12 protein homologtachykinin-4endokininpreprotachykinin-Ctachykinin 4 (hemokinin)
Modification date2020031320200313
UniProtAcc

Q15022

.
Ensembl transtripts involved in fusion geneENST idsENST00000322652, ENST00000580398, 
ENST00000326219, ENST00000334568, 
ENST00000352793, ENST00000398154, 
ENST00000436235, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 12 X 10=18003 X 2 X 2=12
# samples 154
** MAII scorelog2(15/1800*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SUZ12 [Title/Abstract] AND TAC4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SUZ12(30320352)-TAC4(47921519), # samples:1
Anticipated loss of major functional domain due to fusion event.SUZ12-TAC4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SUZ12-TAC4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SUZ12-TAC4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SUZ12-TAC4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTAC4

GO:1902093

positive regulation of flagellated sperm motility

17437961


check buttonFusion gene breakpoints across SUZ12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TAC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A06Q-01ASUZ12chr17

30320352

+TAC4chr17

47921519

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000322652SUZ12chr1730320352+ENST00000326219TAC4chr1747921519-20141522371680547
ENST00000322652SUZ12chr1730320352+ENST00000352793TAC4chr1747921519-19811522371647536
ENST00000322652SUZ12chr1730320352+ENST00000436235TAC4chr1747921519-20741522371740567
ENST00000322652SUZ12chr1730320352+ENST00000398154TAC4chr1747921519-20411522371707556
ENST00000322652SUZ12chr1730320352+ENST00000334568TAC4chr1747921519-20741522371740567
ENST00000580398SUZ12chr1730320352+ENST00000326219TAC4chr1747921519-189614041081562484
ENST00000580398SUZ12chr1730320352+ENST00000352793TAC4chr1747921519-186314041081529473
ENST00000580398SUZ12chr1730320352+ENST00000436235TAC4chr1747921519-195614041081622504
ENST00000580398SUZ12chr1730320352+ENST00000398154TAC4chr1747921519-192314041081589493
ENST00000580398SUZ12chr1730320352+ENST00000334568TAC4chr1747921519-195614041081622504

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000322652ENST00000326219SUZ12chr1730320352+TAC4chr1747921519-0.0038134580.99618655
ENST00000322652ENST00000352793SUZ12chr1730320352+TAC4chr1747921519-0.0030474540.99695253
ENST00000322652ENST00000436235SUZ12chr1730320352+TAC4chr1747921519-0.0041499310.9958501
ENST00000322652ENST00000398154SUZ12chr1730320352+TAC4chr1747921519-0.0033571050.99664295
ENST00000322652ENST00000334568SUZ12chr1730320352+TAC4chr1747921519-0.0041499310.9958501
ENST00000580398ENST00000326219SUZ12chr1730320352+TAC4chr1747921519-0.0033624280.9966376
ENST00000580398ENST00000352793SUZ12chr1730320352+TAC4chr1747921519-0.0025089290.9974911
ENST00000580398ENST00000436235SUZ12chr1730320352+TAC4chr1747921519-0.0048334360.99516654
ENST00000580398ENST00000398154SUZ12chr1730320352+TAC4chr1747921519-0.0035077580.9964922
ENST00000580398ENST00000334568SUZ12chr1730320352+TAC4chr1747921519-0.0048334360.99516654

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>88263_88263_1_SUZ12-TAC4_SUZ12_chr17_30320352_ENST00000322652_TAC4_chr17_47921519_ENST00000326219_length(amino acids)=547AA_BP=5
MRRHFFFPPSFPPLLLPSLPLSSPLSSFPPRSAGACWGERLVLQALALRGRPAGSWRGEEAGTAMAPQKHGGGGGGGSGPSAGSGGGGFG
GSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLT
YMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQV
PTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFV
AQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLH
QENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQEGAGPSIQLQLQEVKTGKASQFFGLMGKRVGGRPLIQPRRKKGRE

--------------------------------------------------------------

>88263_88263_2_SUZ12-TAC4_SUZ12_chr17_30320352_ENST00000322652_TAC4_chr17_47921519_ENST00000334568_length(amino acids)=567AA_BP=5
MRRHFFFPPSFPPLLLPSLPLSSPLSSFPPRSAGACWGERLVLQALALRGRPAGSWRGEEAGTAMAPQKHGGGGGGGSGPSAGSGGGGFG
GSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLT
YMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQV
PTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFV
AQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLH
QENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQEGAGPSIQLQLQEVKTGKASQFFGLMGKRVGGRPLIQPRRKKAYQ

--------------------------------------------------------------

>88263_88263_3_SUZ12-TAC4_SUZ12_chr17_30320352_ENST00000322652_TAC4_chr17_47921519_ENST00000352793_length(amino acids)=536AA_BP=5
MRRHFFFPPSFPPLLLPSLPLSSPLSSFPPRSAGACWGERLVLQALALRGRPAGSWRGEEAGTAMAPQKHGGGGGGGSGPSAGSGGGGFG
GSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLT
YMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQV
PTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFV
AQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLH

--------------------------------------------------------------

>88263_88263_4_SUZ12-TAC4_SUZ12_chr17_30320352_ENST00000322652_TAC4_chr17_47921519_ENST00000398154_length(amino acids)=556AA_BP=5
MRRHFFFPPSFPPLLLPSLPLSSPLSSFPPRSAGACWGERLVLQALALRGRPAGSWRGEEAGTAMAPQKHGGGGGGGSGPSAGSGGGGFG
GSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLT
YMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQV
PTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFV
AQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLH
QENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQEGAGPSIQLQLQEVKTGKASQFFGLMGKRVGAYQLEHTFQGLLGK

--------------------------------------------------------------

>88263_88263_5_SUZ12-TAC4_SUZ12_chr17_30320352_ENST00000322652_TAC4_chr17_47921519_ENST00000436235_length(amino acids)=567AA_BP=5
MRRHFFFPPSFPPLLLPSLPLSSPLSSFPPRSAGACWGERLVLQALALRGRPAGSWRGEEAGTAMAPQKHGGGGGGGSGPSAGSGGGGFG
GSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLT
YMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQV
PTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFV
AQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLH
QENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQEGAGPSIQLQLQEVKTGKASQFFGLMGKRVGGRPLIQPRRKKAYQ

--------------------------------------------------------------

>88263_88263_6_SUZ12-TAC4_SUZ12_chr17_30320352_ENST00000580398_TAC4_chr17_47921519_ENST00000326219_length(amino acids)=484AA_BP=431
MVLQALALRGRPAGSWRGEEAGTAMAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGA
AVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKSLSAHLQLTFTGFFHKNDKPSPNSENEQ
NSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGE
TNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTL
RWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQEGAGPSIQLQLQEVKTGK

--------------------------------------------------------------

>88263_88263_7_SUZ12-TAC4_SUZ12_chr17_30320352_ENST00000580398_TAC4_chr17_47921519_ENST00000334568_length(amino acids)=504AA_BP=431
MVLQALALRGRPAGSWRGEEAGTAMAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGA
AVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKSLSAHLQLTFTGFFHKNDKPSPNSENEQ
NSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGE
TNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTL
RWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQEGAGPSIQLQLQEVKTGK

--------------------------------------------------------------

>88263_88263_8_SUZ12-TAC4_SUZ12_chr17_30320352_ENST00000580398_TAC4_chr17_47921519_ENST00000352793_length(amino acids)=473AA_BP=431
MVLQALALRGRPAGSWRGEEAGTAMAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGA
AVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKSLSAHLQLTFTGFFHKNDKPSPNSENEQ
NSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGE
TNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTL
RWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQEGAGPSIQLQLQEVKTGK

--------------------------------------------------------------

>88263_88263_9_SUZ12-TAC4_SUZ12_chr17_30320352_ENST00000580398_TAC4_chr17_47921519_ENST00000398154_length(amino acids)=493AA_BP=431
MVLQALALRGRPAGSWRGEEAGTAMAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGA
AVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKSLSAHLQLTFTGFFHKNDKPSPNSENEQ
NSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGE
TNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTL
RWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQEGAGPSIQLQLQEVKTGK

--------------------------------------------------------------

>88263_88263_10_SUZ12-TAC4_SUZ12_chr17_30320352_ENST00000580398_TAC4_chr17_47921519_ENST00000436235_length(amino acids)=504AA_BP=431
MVLQALALRGRPAGSWRGEEAGTAMAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGA
AVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKSLSAHLQLTFTGFFHKNDKPSPNSENEQ
NSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGE
TNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTL
RWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQEGAGPSIQLQLQEVKTGK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:30320352/chr17:47921519)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SUZ12

Q15022

.
FUNCTION: Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12435631, PubMed:12351676, PubMed:15385962, PubMed:15099518, PubMed:15225548, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). {ECO:0000269|PubMed:12351676, ECO:0000269|PubMed:12435631, ECO:0000269|PubMed:15099518, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:16431907, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17200670, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSUZ12chr17:30320352chr17:47921519ENST00000322652+111651_59431.0740.0Compositional biasNote=Poly-Ser
HgeneSUZ12chr17:30320352chr17:47921519ENST00000322652+111660_67431.0740.0Compositional biasNote=Poly-Ala
HgeneSUZ12chr17:30320352chr17:47921519ENST00000322652+11167_50431.0740.0Compositional biasNote=Gly-rich

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSUZ12chr17:30320352chr17:47921519ENST00000322652+1116563_639431.0740.0RegionNote=VEFS-box
HgeneSUZ12chr17:30320352chr17:47921519ENST00000322652+1116448_471431.0740.0Zinc fingerNote=C2H2-type


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SUZ12all structure
TAC4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SUZ12-TAC4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SUZ12-TAC4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSUZ12C0206727Nerve Sheath Tumors2CTD_human
HgeneSUZ12C0751689Peripheral Nerve Sheath Neoplasm2CTD_human
HgeneSUZ12C0751691Perineurioma2CTD_human
HgeneSUZ12C0001430Adenoma1CTD_human
HgeneSUZ12C0014170Endometrial Neoplasms1CTD_human
HgeneSUZ12C0017636Glioblastoma1CTD_human
HgeneSUZ12C0017638Glioma1CTD_human
HgeneSUZ12C0025202melanoma1CTD_human
HgeneSUZ12C0027809Neurilemmoma1CTD_human
HgeneSUZ12C0027830neurofibroma1CTD_human
HgeneSUZ12C0027962Melanocytic nevus1CTD_human
HgeneSUZ12C0042063Urogenital Abnormalities1GENOMICS_ENGLAND
HgeneSUZ12C0205646Adenoma, Basal Cell1CTD_human
HgeneSUZ12C0205647Follicular adenoma1CTD_human
HgeneSUZ12C0205648Adenoma, Microcystic1CTD_human
HgeneSUZ12C0205649Adenoma, Monomorphic1CTD_human
HgeneSUZ12C0205650Papillary adenoma1CTD_human
HgeneSUZ12C0205651Adenoma, Trabecular1CTD_human
HgeneSUZ12C0206630Endometrial Stromal Sarcoma1ORPHANET
HgeneSUZ12C0259783mixed gliomas1CTD_human
HgeneSUZ12C0265210Weaver syndrome1ORPHANET
HgeneSUZ12C0334588Giant Cell Glioblastoma1CTD_human
HgeneSUZ12C0476089Endometrial Carcinoma1CTD_human
HgeneSUZ12C0545053Advanced bone age1GENOMICS_ENGLAND
HgeneSUZ12C0555198Malignant Glioma1CTD_human
HgeneSUZ12C0557874Global developmental delay1GENOMICS_ENGLAND
HgeneSUZ12C0751374Schwannomatosis, Plexiform1CTD_human
HgeneSUZ12C1621958Glioblastoma Multiforme1CTD_human
HgeneSUZ12C1842581Abnormal corpus callosum morphology1GENOMICS_ENGLAND
HgeneSUZ12C1849265Overgrowth1GENOMICS_ENGLAND
HgeneSUZ12C3714756Intellectual Disability1GENOMICS_ENGLAND
HgeneSUZ12C4018871Abnormality of the respiratory system1GENOMICS_ENGLAND
HgeneSUZ12C4021664Abnormality of the abdominal wall1GENOMICS_ENGLAND
HgeneSUZ12C4021790Abnormality of the skeletal system1GENOMICS_ENGLAND