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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SYCP2-CTCFL

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SYCP2-CTCFL
FusionPDB ID: 88333
FusionGDB2.0 ID: 88333
HgeneTgene
Gene symbol

SYCP2

CTCFL

Gene ID

10388

140690

Gene namesynaptonemal complex protein 2CCCTC-binding factor like
SynonymsSCP-2|SCP2|SPGF1BORIS|CT27|CTCF-T|HMGB1L1|dJ579F20.2
Cytomap

20q13.33

20q13.31

Type of geneprotein-codingprotein-coding
Descriptionsynaptonemal complex protein 2synaptonemal complex lateral element proteintranscriptional repressor CTCFLBORIS-like proteinbrother of the regulator of imprinted sitescancer/testis antigen 27
Modification date2020031320200313
UniProtAcc.

Q8NI51

Ensembl transtripts involved in fusion geneENST idsENST00000357552, ENST00000371001, 
ENST00000476314, 		ENST00000608858, 
ENST00000422869, ENST00000432255, 
ENST00000481655, ENST00000539382, 
ENST00000608158, ENST00000608425, 
ENST00000608903, ENST00000243914, 
ENST00000371196, ENST00000423479, 
ENST00000429804, ENST00000433949, 
ENST00000502686, ENST00000608263, 
ENST00000608440, ENST00000609232, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 4 X 3=482 X 2 X 2=8
# samples 52
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: SYCP2 [Title/Abstract] AND CTCFL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SYCP2(58442765)-CTCFL(56090890), # samples:1
Anticipated loss of major functional domain due to fusion event.SYCP2-CTCFL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SYCP2-CTCFL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SYCP2-CTCFL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SYCP2-CTCFL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SYCP2-CTCFL seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SYCP2-CTCFL seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SYCP2-CTCFL seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
SYCP2-CTCFL seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCTCFL

GO:0010628

positive regulation of gene expression

18413740

TgeneCTCFL

GO:0045893

positive regulation of transcription, DNA-templated

18413740

TgeneCTCFL

GO:0045944

positive regulation of transcription by RNA polymerase II

16140944


check buttonFusion gene breakpoints across SYCP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CTCFL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-57-1994SYCP2chr20

58442765

-CTCFLchr20

56090890

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357552SYCP2chr2058442765-ENST00000423479CTCFLchr2056090890-5666435115153941747
ENST00000357552SYCP2chr2058442765-ENST00000608263CTCFLchr2056090890-6670435115152831710
ENST00000357552SYCP2chr2058442765-ENST00000429804CTCFLchr2056090890-6520435115151331660
ENST00000357552SYCP2chr2058442765-ENST00000609232CTCFLchr2056090890-6670435115152831710
ENST00000357552SYCP2chr2058442765-ENST00000243914CTCFLchr2056090890-6666435115152831710
ENST00000357552SYCP2chr2058442765-ENST00000371196CTCFLchr2056090890-6666435115152831710
ENST00000357552SYCP2chr2058442765-ENST00000608440CTCFLchr2056090890-5989435115152891712
ENST00000357552SYCP2chr2058442765-ENST00000433949CTCFLchr2056090890-5989435115152891712
ENST00000357552SYCP2chr2058442765-ENST00000502686CTCFLchr2056090890-5989435115152891712

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357552ENST00000423479SYCP2chr2058442765-CTCFLchr2056090890-0.000295460.99970454
ENST00000357552ENST00000608263SYCP2chr2058442765-CTCFLchr2056090890-0.0001168130.9998832
ENST00000357552ENST00000429804SYCP2chr2058442765-CTCFLchr2056090890-0.0006149350.999385
ENST00000357552ENST00000609232SYCP2chr2058442765-CTCFLchr2056090890-0.0001168130.9998832
ENST00000357552ENST00000243914SYCP2chr2058442765-CTCFLchr2056090890-0.0001177530.9998822
ENST00000357552ENST00000371196SYCP2chr2058442765-CTCFLchr2056090890-0.0001177530.9998822
ENST00000357552ENST00000608440SYCP2chr2058442765-CTCFLchr2056090890-0.0002999750.99970007
ENST00000357552ENST00000433949SYCP2chr2058442765-CTCFLchr2056090890-0.0002999750.99970007
ENST00000357552ENST00000502686SYCP2chr2058442765-CTCFLchr2056090890-0.0002999750.99970007

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>88333_88333_1_SYCP2-CTCFL_SYCP2_chr20_58442765_ENST00000357552_CTCFL_chr20_56090890_ENST00000243914_length(amino acids)=1710AA_BP=672
MEPRACLLVRCLFCLAFFFFLNEVKMPIRPDLQQLEKCIDDALRKNDFKPLKTLLQIDICEDVKIKCSKQFFHKVDNLICRELNKEDIHN
VSAILVSVGRCGKNISVLGQAGLLTMIKQGLIQKMVAWFEKSKDIIQSQGNSKDEAVLNMIEDLVDLLLVIHDVSDEGKKQVVESFVPRI
CSLVIDSRVNICIQQEIIKKMNAMLDKMPQDARKILSNQEMLILMSSMGERILDAGDYDLQVGIVEALCRMTTEKQRQELAHQWFSMDFI
AKAFKRIKDSEFETDCRIFLNLVNGMLGDKRRVFTFPCLSAFLDKYELQIPSDEKLEEFWIDFNLGSQTLSFYIAGDNDDHQWEAVTVPE
EKVQIYSIEVRESKKLLTIILKNTVKISKREGKELLLYFDASLEITNVTQKIFGATKHRESIRKQGISVAKTSLHILFDASGSQILVPES
QISPVGEELVSLKEKSKSPKEFAKPSKYIKNSDKGNRNNSQLEKTTPSKRKMSEASMIVSGADRYTMRSPVLFSNTSIPPRRRRIKPPLQ
MTSSAEKPSVSQTSENRVDNAASLKSRSSEGRHRRDNIDKHIKTAKCVENTENKNVEFPNQNFSELQDVIPDSQAAEKRDHTILPGVLDN
ICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQDIVINKKLTKQKSSSSISDHNSEGTGKVKYKKEQTDHIKIDKAEVEVCKKHNQ
QQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKTIEESLIYRKKYILSKDVNTATCDKNPSASKNVQSHRKAEKELTSELNSWDSKQ
KKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTRKLKESLINSGFSNKPVVQLSKEKVQKKSYRKLKTTFVNVTSECPVNDVYNFNL
NGADDPIIKLGIQEFQATAKEACADRSIRLVGPRNHDELKSSVKTKDKKIITNHQKKNLFSDTETEYRCDDSKTDISWLREPKSKPQLID
YSRNKNVKNHKSGKSRSSLEKGQPSSKMTPSKNITKKMDKTIPEGRIRLPRKATKTKKNYKDLSNSESECEQEFSHSFKENIPVKEENIH
SRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDAIRDNCLDLSPRSLSGSPSSIEVTRCIEKITEKDFTQDYDCITKSISPYPKTSS
LESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRPLFLPRHTPTKSNTIVNRKKISSLVLTQETQNSNSYSDVSSYSSEERFMEIESP
HINENYIQSKREESHLASSLSKSSEGREKTWFDMPCDATHVSGPTQHLSRKRIYIEDNLSNSNEVEMEEKGERRANLLPKKLCKIEDADH
HIHKMSESVSSLSTNDFSIPWETWQNEFAGIEMTYETYERLNSEFKRRNNASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHS
GEKPYECHICHTRFTQSGTMKIHILQKHGENVPKYQCPHCATIIARKSDLRVHMRNLHAYSAAELKCRYCSAVFHERYALIQHQKTHKNE
KRFKCKHCSYACKQERHMTAHIRTHTGEKPFTCLSCNKCFRQKQLLNAHFRKYHDANFIPTVYKCSKCGKGFSRWINLHRHSEKCGSGEA
KSAASGKGRRTRKRKQTILKEATKGQKEAAKGWKEAANGDEAAAEEASTTKGEQFPGEMFPVACRETTARVKEEVDEGVTCEMLLNTMDK

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>88333_88333_2_SYCP2-CTCFL_SYCP2_chr20_58442765_ENST00000357552_CTCFL_chr20_56090890_ENST00000371196_length(amino acids)=1710AA_BP=672
MEPRACLLVRCLFCLAFFFFLNEVKMPIRPDLQQLEKCIDDALRKNDFKPLKTLLQIDICEDVKIKCSKQFFHKVDNLICRELNKEDIHN
VSAILVSVGRCGKNISVLGQAGLLTMIKQGLIQKMVAWFEKSKDIIQSQGNSKDEAVLNMIEDLVDLLLVIHDVSDEGKKQVVESFVPRI
CSLVIDSRVNICIQQEIIKKMNAMLDKMPQDARKILSNQEMLILMSSMGERILDAGDYDLQVGIVEALCRMTTEKQRQELAHQWFSMDFI
AKAFKRIKDSEFETDCRIFLNLVNGMLGDKRRVFTFPCLSAFLDKYELQIPSDEKLEEFWIDFNLGSQTLSFYIAGDNDDHQWEAVTVPE
EKVQIYSIEVRESKKLLTIILKNTVKISKREGKELLLYFDASLEITNVTQKIFGATKHRESIRKQGISVAKTSLHILFDASGSQILVPES
QISPVGEELVSLKEKSKSPKEFAKPSKYIKNSDKGNRNNSQLEKTTPSKRKMSEASMIVSGADRYTMRSPVLFSNTSIPPRRRRIKPPLQ
MTSSAEKPSVSQTSENRVDNAASLKSRSSEGRHRRDNIDKHIKTAKCVENTENKNVEFPNQNFSELQDVIPDSQAAEKRDHTILPGVLDN
ICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQDIVINKKLTKQKSSSSISDHNSEGTGKVKYKKEQTDHIKIDKAEVEVCKKHNQ
QQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKTIEESLIYRKKYILSKDVNTATCDKNPSASKNVQSHRKAEKELTSELNSWDSKQ
KKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTRKLKESLINSGFSNKPVVQLSKEKVQKKSYRKLKTTFVNVTSECPVNDVYNFNL
NGADDPIIKLGIQEFQATAKEACADRSIRLVGPRNHDELKSSVKTKDKKIITNHQKKNLFSDTETEYRCDDSKTDISWLREPKSKPQLID
YSRNKNVKNHKSGKSRSSLEKGQPSSKMTPSKNITKKMDKTIPEGRIRLPRKATKTKKNYKDLSNSESECEQEFSHSFKENIPVKEENIH
SRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDAIRDNCLDLSPRSLSGSPSSIEVTRCIEKITEKDFTQDYDCITKSISPYPKTSS
LESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRPLFLPRHTPTKSNTIVNRKKISSLVLTQETQNSNSYSDVSSYSSEERFMEIESP
HINENYIQSKREESHLASSLSKSSEGREKTWFDMPCDATHVSGPTQHLSRKRIYIEDNLSNSNEVEMEEKGERRANLLPKKLCKIEDADH
HIHKMSESVSSLSTNDFSIPWETWQNEFAGIEMTYETYERLNSEFKRRNNASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHS
GEKPYECHICHTRFTQSGTMKIHILQKHGENVPKYQCPHCATIIARKSDLRVHMRNLHAYSAAELKCRYCSAVFHERYALIQHQKTHKNE
KRFKCKHCSYACKQERHMTAHIRTHTGEKPFTCLSCNKCFRQKQLLNAHFRKYHDANFIPTVYKCSKCGKGFSRWINLHRHSEKCGSGEA
KSAASGKGRRTRKRKQTILKEATKGQKEAAKGWKEAANGDEAAAEEASTTKGEQFPGEMFPVACRETTARVKEEVDEGVTCEMLLNTMDK

--------------------------------------------------------------

>88333_88333_3_SYCP2-CTCFL_SYCP2_chr20_58442765_ENST00000357552_CTCFL_chr20_56090890_ENST00000423479_length(amino acids)=1747AA_BP=672
MEPRACLLVRCLFCLAFFFFLNEVKMPIRPDLQQLEKCIDDALRKNDFKPLKTLLQIDICEDVKIKCSKQFFHKVDNLICRELNKEDIHN
VSAILVSVGRCGKNISVLGQAGLLTMIKQGLIQKMVAWFEKSKDIIQSQGNSKDEAVLNMIEDLVDLLLVIHDVSDEGKKQVVESFVPRI
CSLVIDSRVNICIQQEIIKKMNAMLDKMPQDARKILSNQEMLILMSSMGERILDAGDYDLQVGIVEALCRMTTEKQRQELAHQWFSMDFI
AKAFKRIKDSEFETDCRIFLNLVNGMLGDKRRVFTFPCLSAFLDKYELQIPSDEKLEEFWIDFNLGSQTLSFYIAGDNDDHQWEAVTVPE
EKVQIYSIEVRESKKLLTIILKNTVKISKREGKELLLYFDASLEITNVTQKIFGATKHRESIRKQGISVAKTSLHILFDASGSQILVPES
QISPVGEELVSLKEKSKSPKEFAKPSKYIKNSDKGNRNNSQLEKTTPSKRKMSEASMIVSGADRYTMRSPVLFSNTSIPPRRRRIKPPLQ
MTSSAEKPSVSQTSENRVDNAASLKSRSSEGRHRRDNIDKHIKTAKCVENTENKNVEFPNQNFSELQDVIPDSQAAEKRDHTILPGVLDN
ICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQDIVINKKLTKQKSSSSISDHNSEGTGKVKYKKEQTDHIKIDKAEVEVCKKHNQ
QQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKTIEESLIYRKKYILSKDVNTATCDKNPSASKNVQSHRKAEKELTSELNSWDSKQ
KKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTRKLKESLINSGFSNKPVVQLSKEKVQKKSYRKLKTTFVNVTSECPVNDVYNFNL
NGADDPIIKLGIQEFQATAKEACADRSIRLVGPRNHDELKSSVKTKDKKIITNHQKKNLFSDTETEYRCDDSKTDISWLREPKSKPQLID
YSRNKNVKNHKSGKSRSSLEKGQPSSKMTPSKNITKKMDKTIPEGRIRLPRKATKTKKNYKDLSNSESECEQEFSHSFKENIPVKEENIH
SRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDAIRDNCLDLSPRSLSGSPSSIEVTRCIEKITEKDFTQDYDCITKSISPYPKTSS
LESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRPLFLPRHTPTKSNTIVNRKKISSLVLTQETQNSNSYSDVSSYSSEERFMEIESP
HINENYIQSKREESHLASSLSKSSEGREKTWFDMPCDATHVSGPTQHLSRKRIYIEDNLSNSNEVEMEEKGERRANLLPKKLCKIEDADH
HIHKMSESVSSLSTNDFSIPWETWQNEFAGIEMTYETYERLNSEFKRRNNASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHS
GEKPYECHICHTRFTQSGTMKIHILQKHGENVPKYQCPHCATIIARKSDLRVHMRNLHAYSAAELKCRYCSAVFHERYALIQHQKTHKNE
KRFKCKHCSYACKQERHMTAHIRTHTGEKPFTCLSCNKCFRQKQLLNAHFRKYHDANFIPTVYKCSKCGKGFSRWINLHRHSEKCGSGEA
KSAASGKGRRTRKRKQTILKEATKGQKEAAKGWKEAANGDEAAAEEASTTKGEQFPGEMFPVACRETTARVKEEVDEGVTCEMLLNTMDN

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>88333_88333_4_SYCP2-CTCFL_SYCP2_chr20_58442765_ENST00000357552_CTCFL_chr20_56090890_ENST00000429804_length(amino acids)=1660AA_BP=1400
MEPRACLLVRCLFCLAFFFFLNEVKMPIRPDLQQLEKCIDDALRKNDFKPLKTLLQIDICEDVKIKCSKQFFHKVDNLICRELNKEDIHN
VSAILVSVGRCGKNISVLGQAGLLTMIKQGLIQKMVAWFEKSKDIIQSQGNSKDEAVLNMIEDLVDLLLVIHDVSDEGKKQVVESFVPRI
CSLVIDSRVNICIQQEIIKKMNAMLDKMPQDARKILSNQEMLILMSSMGERILDAGDYDLQVGIVEALCRMTTEKQRQELAHQWFSMDFI
AKAFKRIKDSEFETDCRIFLNLVNGMLGDKRRVFTFPCLSAFLDKYELQIPSDEKLEEFWIDFNLGSQTLSFYIAGDNDDHQWEAVTVPE
EKVQIYSIEVRESKKLLTIILKNTVKISKREGKELLLYFDASLEITNVTQKIFGATKHRESIRKQGISVAKTSLHILFDASGSQILVPES
QISPVGEELVSLKEKSKSPKEFAKPSKYIKNSDKGNRNNSQLEKTTPSKRKMSEASMIVSGADRYTMRSPVLFSNTSIPPRRRRIKPPLQ
MTSSAEKPSVSQTSENRVDNAASLKSRSSEGRHRRDNIDKHIKTAKCVENTENKNVEFPNQNFSELQDVIPDSQAAEKRDHTILPGVLDN
ICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQDIVINKKLTKQKSSSSISDHNSEGTGKVKYKKEQTDHIKIDKAEVEVCKKHNQ
QQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKTIEESLIYRKKYILSKDVNTATCDKNPSASKNVQSHRKAEKELTSELNSWDSKQ
KKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTRKLKESLINSGFSNKPVVQLSKEKVQKKSYRKLKTTFVNVTSECPVNDVYNFNL
NGADDPIIKLGIQEFQATAKEACADRSIRLVGPRNHDELKSSVKTKDKKIITNHQKKNLFSDTETEYRCDDSKTDISWLREPKSKPQLID
YSRNKNVKNHKSGKSRSSLEKGQPSSKMTPSKNITKKMDKTIPEGRIRLPRKATKTKKNYKDLSNSESECEQEFSHSFKENIPVKEENIH
SRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDAIRDNCLDLSPRSLSGSPSSIEVTRCIEKITEKDFTQDYDCITKSISPYPKTSS
LESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRPLFLPRHTPTKSNTIVNRKKISSLVLTQETQNSNSYSDVSSYSSEERFMEIESP
HINENYIQSKREESHLASSLSKSSEGREKTWFDMPCDATHVSGPTQHLSRKRIYIEDNLSNSNEVEMEEKGERRANLLPKKLCKIEDADH
HIHKMSESVSSLSTNDFSIPWETWQNEFAGIEMTYETYERLNSEFKRRNNASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHS
GVHMRNLHAYSAAELKCRYCSAVFHERYALIQHQKTHKNEKRFKCKHCSYACKQERHMTAHIRTHTGEKPFTCLSCNKCFRQKQLLNAHF
RKYHDANFIPTVYKCSKCGKGFSRWINLHRHSEKCGSGEAKSAASGKGRRTRKRKQTILKEATKGQKEAAKGWKEAANGDEAAAEEASTT

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>88333_88333_5_SYCP2-CTCFL_SYCP2_chr20_58442765_ENST00000357552_CTCFL_chr20_56090890_ENST00000433949_length(amino acids)=1712AA_BP=672
MEPRACLLVRCLFCLAFFFFLNEVKMPIRPDLQQLEKCIDDALRKNDFKPLKTLLQIDICEDVKIKCSKQFFHKVDNLICRELNKEDIHN
VSAILVSVGRCGKNISVLGQAGLLTMIKQGLIQKMVAWFEKSKDIIQSQGNSKDEAVLNMIEDLVDLLLVIHDVSDEGKKQVVESFVPRI
CSLVIDSRVNICIQQEIIKKMNAMLDKMPQDARKILSNQEMLILMSSMGERILDAGDYDLQVGIVEALCRMTTEKQRQELAHQWFSMDFI
AKAFKRIKDSEFETDCRIFLNLVNGMLGDKRRVFTFPCLSAFLDKYELQIPSDEKLEEFWIDFNLGSQTLSFYIAGDNDDHQWEAVTVPE
EKVQIYSIEVRESKKLLTIILKNTVKISKREGKELLLYFDASLEITNVTQKIFGATKHRESIRKQGISVAKTSLHILFDASGSQILVPES
QISPVGEELVSLKEKSKSPKEFAKPSKYIKNSDKGNRNNSQLEKTTPSKRKMSEASMIVSGADRYTMRSPVLFSNTSIPPRRRRIKPPLQ
MTSSAEKPSVSQTSENRVDNAASLKSRSSEGRHRRDNIDKHIKTAKCVENTENKNVEFPNQNFSELQDVIPDSQAAEKRDHTILPGVLDN
ICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQDIVINKKLTKQKSSSSISDHNSEGTGKVKYKKEQTDHIKIDKAEVEVCKKHNQ
QQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKTIEESLIYRKKYILSKDVNTATCDKNPSASKNVQSHRKAEKELTSELNSWDSKQ
KKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTRKLKESLINSGFSNKPVVQLSKEKVQKKSYRKLKTTFVNVTSECPVNDVYNFNL
NGADDPIIKLGIQEFQATAKEACADRSIRLVGPRNHDELKSSVKTKDKKIITNHQKKNLFSDTETEYRCDDSKTDISWLREPKSKPQLID
YSRNKNVKNHKSGKSRSSLEKGQPSSKMTPSKNITKKMDKTIPEGRIRLPRKATKTKKNYKDLSNSESECEQEFSHSFKENIPVKEENIH
SRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDAIRDNCLDLSPRSLSGSPSSIEVTRCIEKITEKDFTQDYDCITKSISPYPKTSS
LESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRPLFLPRHTPTKSNTIVNRKKISSLVLTQETQNSNSYSDVSSYSSEERFMEIESP
HINENYIQSKREESHLASSLSKSSEGREKTWFDMPCDATHVSGPTQHLSRKRIYIEDNLSNSNEVEMEEKGERRANLLPKKLCKIEDADH
HIHKMSESVSSLSTNDFSIPWETWQNEFAGIEMTYETYERLNSEFKRRNNASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHS
GEKPYECHICHTRFTQSGTMKIHILQKHGENVPKYQCPHCATIIARKSDLRVHMRNLHAYSAAELKCRYCSAVFHERYALIQHQKTHKNE
KRFKCKHCSYACKQERHMTAHIRTHTGEKPFTCLSCNKCFRQKQLLNAHFRKYHDANFIPTVYKCSKCGKGFSRWINLHRHSEKCGSGEA
KSAASGKGRRTRKRKQTILKEATKGQKEAAKGWKEAANGDGVISAHRNLCLLGSSDSHASVSGAGITDARHHAWLIVLLFLVEMGFYHVS

--------------------------------------------------------------

>88333_88333_6_SYCP2-CTCFL_SYCP2_chr20_58442765_ENST00000357552_CTCFL_chr20_56090890_ENST00000502686_length(amino acids)=1712AA_BP=672
MEPRACLLVRCLFCLAFFFFLNEVKMPIRPDLQQLEKCIDDALRKNDFKPLKTLLQIDICEDVKIKCSKQFFHKVDNLICRELNKEDIHN
VSAILVSVGRCGKNISVLGQAGLLTMIKQGLIQKMVAWFEKSKDIIQSQGNSKDEAVLNMIEDLVDLLLVIHDVSDEGKKQVVESFVPRI
CSLVIDSRVNICIQQEIIKKMNAMLDKMPQDARKILSNQEMLILMSSMGERILDAGDYDLQVGIVEALCRMTTEKQRQELAHQWFSMDFI
AKAFKRIKDSEFETDCRIFLNLVNGMLGDKRRVFTFPCLSAFLDKYELQIPSDEKLEEFWIDFNLGSQTLSFYIAGDNDDHQWEAVTVPE
EKVQIYSIEVRESKKLLTIILKNTVKISKREGKELLLYFDASLEITNVTQKIFGATKHRESIRKQGISVAKTSLHILFDASGSQILVPES
QISPVGEELVSLKEKSKSPKEFAKPSKYIKNSDKGNRNNSQLEKTTPSKRKMSEASMIVSGADRYTMRSPVLFSNTSIPPRRRRIKPPLQ
MTSSAEKPSVSQTSENRVDNAASLKSRSSEGRHRRDNIDKHIKTAKCVENTENKNVEFPNQNFSELQDVIPDSQAAEKRDHTILPGVLDN
ICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQDIVINKKLTKQKSSSSISDHNSEGTGKVKYKKEQTDHIKIDKAEVEVCKKHNQ
QQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKTIEESLIYRKKYILSKDVNTATCDKNPSASKNVQSHRKAEKELTSELNSWDSKQ
KKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTRKLKESLINSGFSNKPVVQLSKEKVQKKSYRKLKTTFVNVTSECPVNDVYNFNL
NGADDPIIKLGIQEFQATAKEACADRSIRLVGPRNHDELKSSVKTKDKKIITNHQKKNLFSDTETEYRCDDSKTDISWLREPKSKPQLID
YSRNKNVKNHKSGKSRSSLEKGQPSSKMTPSKNITKKMDKTIPEGRIRLPRKATKTKKNYKDLSNSESECEQEFSHSFKENIPVKEENIH
SRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDAIRDNCLDLSPRSLSGSPSSIEVTRCIEKITEKDFTQDYDCITKSISPYPKTSS
LESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRPLFLPRHTPTKSNTIVNRKKISSLVLTQETQNSNSYSDVSSYSSEERFMEIESP
HINENYIQSKREESHLASSLSKSSEGREKTWFDMPCDATHVSGPTQHLSRKRIYIEDNLSNSNEVEMEEKGERRANLLPKKLCKIEDADH
HIHKMSESVSSLSTNDFSIPWETWQNEFAGIEMTYETYERLNSEFKRRNNASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHS
GEKPYECHICHTRFTQSGTMKIHILQKHGENVPKYQCPHCATIIARKSDLRVHMRNLHAYSAAELKCRYCSAVFHERYALIQHQKTHKNE
KRFKCKHCSYACKQERHMTAHIRTHTGEKPFTCLSCNKCFRQKQLLNAHFRKYHDANFIPTVYKCSKCGKGFSRWINLHRHSEKCGSGEA
KSAASGKGRRTRKRKQTILKEATKGQKEAAKGWKEAANGDGVISAHRNLCLLGSSDSHASVSGAGITDARHHAWLIVLLFLVEMGFYHVS

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>88333_88333_7_SYCP2-CTCFL_SYCP2_chr20_58442765_ENST00000357552_CTCFL_chr20_56090890_ENST00000608263_length(amino acids)=1710AA_BP=672
MEPRACLLVRCLFCLAFFFFLNEVKMPIRPDLQQLEKCIDDALRKNDFKPLKTLLQIDICEDVKIKCSKQFFHKVDNLICRELNKEDIHN
VSAILVSVGRCGKNISVLGQAGLLTMIKQGLIQKMVAWFEKSKDIIQSQGNSKDEAVLNMIEDLVDLLLVIHDVSDEGKKQVVESFVPRI
CSLVIDSRVNICIQQEIIKKMNAMLDKMPQDARKILSNQEMLILMSSMGERILDAGDYDLQVGIVEALCRMTTEKQRQELAHQWFSMDFI
AKAFKRIKDSEFETDCRIFLNLVNGMLGDKRRVFTFPCLSAFLDKYELQIPSDEKLEEFWIDFNLGSQTLSFYIAGDNDDHQWEAVTVPE
EKVQIYSIEVRESKKLLTIILKNTVKISKREGKELLLYFDASLEITNVTQKIFGATKHRESIRKQGISVAKTSLHILFDASGSQILVPES
QISPVGEELVSLKEKSKSPKEFAKPSKYIKNSDKGNRNNSQLEKTTPSKRKMSEASMIVSGADRYTMRSPVLFSNTSIPPRRRRIKPPLQ
MTSSAEKPSVSQTSENRVDNAASLKSRSSEGRHRRDNIDKHIKTAKCVENTENKNVEFPNQNFSELQDVIPDSQAAEKRDHTILPGVLDN
ICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQDIVINKKLTKQKSSSSISDHNSEGTGKVKYKKEQTDHIKIDKAEVEVCKKHNQ
QQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKTIEESLIYRKKYILSKDVNTATCDKNPSASKNVQSHRKAEKELTSELNSWDSKQ
KKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTRKLKESLINSGFSNKPVVQLSKEKVQKKSYRKLKTTFVNVTSECPVNDVYNFNL
NGADDPIIKLGIQEFQATAKEACADRSIRLVGPRNHDELKSSVKTKDKKIITNHQKKNLFSDTETEYRCDDSKTDISWLREPKSKPQLID
YSRNKNVKNHKSGKSRSSLEKGQPSSKMTPSKNITKKMDKTIPEGRIRLPRKATKTKKNYKDLSNSESECEQEFSHSFKENIPVKEENIH
SRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDAIRDNCLDLSPRSLSGSPSSIEVTRCIEKITEKDFTQDYDCITKSISPYPKTSS
LESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRPLFLPRHTPTKSNTIVNRKKISSLVLTQETQNSNSYSDVSSYSSEERFMEIESP
HINENYIQSKREESHLASSLSKSSEGREKTWFDMPCDATHVSGPTQHLSRKRIYIEDNLSNSNEVEMEEKGERRANLLPKKLCKIEDADH
HIHKMSESVSSLSTNDFSIPWETWQNEFAGIEMTYETYERLNSEFKRRNNASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHS
GEKPYECHICHTRFTQSGTMKIHILQKHGENVPKYQCPHCATIIARKSDLRVHMRNLHAYSAAELKCRYCSAVFHERYALIQHQKTHKNE
KRFKCKHCSYACKQERHMTAHIRTHTGEKPFTCLSCNKCFRQKQLLNAHFRKYHDANFIPTVYKCSKCGKGFSRWINLHRHSEKCGSGEA
KSAASGKGRRTRKRKQTILKEATKGQKEAAKGWKEAANGDEAAAEEASTTKGEQFPGEMFPVACRETTARVKEEVDEGVTCEMLLNTMDK

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>88333_88333_8_SYCP2-CTCFL_SYCP2_chr20_58442765_ENST00000357552_CTCFL_chr20_56090890_ENST00000608440_length(amino acids)=1712AA_BP=672
MEPRACLLVRCLFCLAFFFFLNEVKMPIRPDLQQLEKCIDDALRKNDFKPLKTLLQIDICEDVKIKCSKQFFHKVDNLICRELNKEDIHN
VSAILVSVGRCGKNISVLGQAGLLTMIKQGLIQKMVAWFEKSKDIIQSQGNSKDEAVLNMIEDLVDLLLVIHDVSDEGKKQVVESFVPRI
CSLVIDSRVNICIQQEIIKKMNAMLDKMPQDARKILSNQEMLILMSSMGERILDAGDYDLQVGIVEALCRMTTEKQRQELAHQWFSMDFI
AKAFKRIKDSEFETDCRIFLNLVNGMLGDKRRVFTFPCLSAFLDKYELQIPSDEKLEEFWIDFNLGSQTLSFYIAGDNDDHQWEAVTVPE
EKVQIYSIEVRESKKLLTIILKNTVKISKREGKELLLYFDASLEITNVTQKIFGATKHRESIRKQGISVAKTSLHILFDASGSQILVPES
QISPVGEELVSLKEKSKSPKEFAKPSKYIKNSDKGNRNNSQLEKTTPSKRKMSEASMIVSGADRYTMRSPVLFSNTSIPPRRRRIKPPLQ
MTSSAEKPSVSQTSENRVDNAASLKSRSSEGRHRRDNIDKHIKTAKCVENTENKNVEFPNQNFSELQDVIPDSQAAEKRDHTILPGVLDN
ICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQDIVINKKLTKQKSSSSISDHNSEGTGKVKYKKEQTDHIKIDKAEVEVCKKHNQ
QQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKTIEESLIYRKKYILSKDVNTATCDKNPSASKNVQSHRKAEKELTSELNSWDSKQ
KKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTRKLKESLINSGFSNKPVVQLSKEKVQKKSYRKLKTTFVNVTSECPVNDVYNFNL
NGADDPIIKLGIQEFQATAKEACADRSIRLVGPRNHDELKSSVKTKDKKIITNHQKKNLFSDTETEYRCDDSKTDISWLREPKSKPQLID
YSRNKNVKNHKSGKSRSSLEKGQPSSKMTPSKNITKKMDKTIPEGRIRLPRKATKTKKNYKDLSNSESECEQEFSHSFKENIPVKEENIH
SRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDAIRDNCLDLSPRSLSGSPSSIEVTRCIEKITEKDFTQDYDCITKSISPYPKTSS
LESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRPLFLPRHTPTKSNTIVNRKKISSLVLTQETQNSNSYSDVSSYSSEERFMEIESP
HINENYIQSKREESHLASSLSKSSEGREKTWFDMPCDATHVSGPTQHLSRKRIYIEDNLSNSNEVEMEEKGERRANLLPKKLCKIEDADH
HIHKMSESVSSLSTNDFSIPWETWQNEFAGIEMTYETYERLNSEFKRRNNASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHS
GEKPYECHICHTRFTQSGTMKIHILQKHGENVPKYQCPHCATIIARKSDLRVHMRNLHAYSAAELKCRYCSAVFHERYALIQHQKTHKNE
KRFKCKHCSYACKQERHMTAHIRTHTGEKPFTCLSCNKCFRQKQLLNAHFRKYHDANFIPTVYKCSKCGKGFSRWINLHRHSEKCGSGEA
KSAASGKGRRTRKRKQTILKEATKGQKEAAKGWKEAANGDGVISAHRNLCLLGSSDSHASVSGAGITDARHHAWLIVLLFLVEMGFYHVS

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>88333_88333_9_SYCP2-CTCFL_SYCP2_chr20_58442765_ENST00000357552_CTCFL_chr20_56090890_ENST00000609232_length(amino acids)=1710AA_BP=672
MEPRACLLVRCLFCLAFFFFLNEVKMPIRPDLQQLEKCIDDALRKNDFKPLKTLLQIDICEDVKIKCSKQFFHKVDNLICRELNKEDIHN
VSAILVSVGRCGKNISVLGQAGLLTMIKQGLIQKMVAWFEKSKDIIQSQGNSKDEAVLNMIEDLVDLLLVIHDVSDEGKKQVVESFVPRI
CSLVIDSRVNICIQQEIIKKMNAMLDKMPQDARKILSNQEMLILMSSMGERILDAGDYDLQVGIVEALCRMTTEKQRQELAHQWFSMDFI
AKAFKRIKDSEFETDCRIFLNLVNGMLGDKRRVFTFPCLSAFLDKYELQIPSDEKLEEFWIDFNLGSQTLSFYIAGDNDDHQWEAVTVPE
EKVQIYSIEVRESKKLLTIILKNTVKISKREGKELLLYFDASLEITNVTQKIFGATKHRESIRKQGISVAKTSLHILFDASGSQILVPES
QISPVGEELVSLKEKSKSPKEFAKPSKYIKNSDKGNRNNSQLEKTTPSKRKMSEASMIVSGADRYTMRSPVLFSNTSIPPRRRRIKPPLQ
MTSSAEKPSVSQTSENRVDNAASLKSRSSEGRHRRDNIDKHIKTAKCVENTENKNVEFPNQNFSELQDVIPDSQAAEKRDHTILPGVLDN
ICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQDIVINKKLTKQKSSSSISDHNSEGTGKVKYKKEQTDHIKIDKAEVEVCKKHNQ
QQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKTIEESLIYRKKYILSKDVNTATCDKNPSASKNVQSHRKAEKELTSELNSWDSKQ
KKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTRKLKESLINSGFSNKPVVQLSKEKVQKKSYRKLKTTFVNVTSECPVNDVYNFNL
NGADDPIIKLGIQEFQATAKEACADRSIRLVGPRNHDELKSSVKTKDKKIITNHQKKNLFSDTETEYRCDDSKTDISWLREPKSKPQLID
YSRNKNVKNHKSGKSRSSLEKGQPSSKMTPSKNITKKMDKTIPEGRIRLPRKATKTKKNYKDLSNSESECEQEFSHSFKENIPVKEENIH
SRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDAIRDNCLDLSPRSLSGSPSSIEVTRCIEKITEKDFTQDYDCITKSISPYPKTSS
LESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRPLFLPRHTPTKSNTIVNRKKISSLVLTQETQNSNSYSDVSSYSSEERFMEIESP
HINENYIQSKREESHLASSLSKSSEGREKTWFDMPCDATHVSGPTQHLSRKRIYIEDNLSNSNEVEMEEKGERRANLLPKKLCKIEDADH
HIHKMSESVSSLSTNDFSIPWETWQNEFAGIEMTYETYERLNSEFKRRNNASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHS
GEKPYECHICHTRFTQSGTMKIHILQKHGENVPKYQCPHCATIIARKSDLRVHMRNLHAYSAAELKCRYCSAVFHERYALIQHQKTHKNE
KRFKCKHCSYACKQERHMTAHIRTHTGEKPFTCLSCNKCFRQKQLLNAHFRKYHDANFIPTVYKCSKCGKGFSRWINLHRHSEKCGSGEA
KSAASGKGRRTRKRKQTILKEATKGQKEAAKGWKEAANGDEAAAEEASTTKGEQFPGEMFPVACRETTARVKEEVDEGVTCEMLLNTMDK

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:58442765/chr20:56090890)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CTCFL

Q8NI51

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. {ECO:0000250, ECO:0000269|PubMed:12011441, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18765639}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSYCP2chr20:58442765chr20:56090890ENST00000357552-3945655_6601375.01531.0Compositional biasNote=Poly-Ser
HgeneSYCP2chr20:58442765chr20:56090890ENST00000371001-3844655_6601375.01531.0Compositional biasNote=Poly-Ser
TgeneCTCFLchr20:58442765chr20:56090890ENST00000243914411370_392353.0664.0Zinc fingerC2H2-type 5
TgeneCTCFLchr20:58442765chr20:56090890ENST00000243914411398_421353.0664.0Zinc fingerC2H2-type 6
TgeneCTCFLchr20:58442765chr20:56090890ENST00000243914411428_451353.0664.0Zinc fingerC2H2-type 7
TgeneCTCFLchr20:58442765chr20:56090890ENST00000243914411458_480353.0664.0Zinc fingerC2H2-type 8
TgeneCTCFLchr20:58442765chr20:56090890ENST00000243914411486_508353.0664.0Zinc fingerC2H2-type 9
TgeneCTCFLchr20:58442765chr20:56090890ENST00000243914411514_537353.0664.0Zinc fingerC2H2-type 10
TgeneCTCFLchr20:58442765chr20:56090890ENST00000243914411546_568353.0664.0Zinc fingerC2H2-type 11%3B atypical
TgeneCTCFLchr20:58442765chr20:56090890ENST00000371196411370_392353.0664.0Zinc fingerC2H2-type 5
TgeneCTCFLchr20:58442765chr20:56090890ENST00000371196411398_421353.0664.0Zinc fingerC2H2-type 6
TgeneCTCFLchr20:58442765chr20:56090890ENST00000371196411428_451353.0664.0Zinc fingerC2H2-type 7
TgeneCTCFLchr20:58442765chr20:56090890ENST00000371196411458_480353.0664.0Zinc fingerC2H2-type 8
TgeneCTCFLchr20:58442765chr20:56090890ENST00000371196411486_508353.0664.0Zinc fingerC2H2-type 9
TgeneCTCFLchr20:58442765chr20:56090890ENST00000371196411514_537353.0664.0Zinc fingerC2H2-type 10
TgeneCTCFLchr20:58442765chr20:56090890ENST00000371196411546_568353.0664.0Zinc fingerC2H2-type 11%3B atypical
TgeneCTCFLchr20:58442765chr20:56090890ENST00000422869410370_392353.0574.0Zinc fingerC2H2-type 5
TgeneCTCFLchr20:58442765chr20:56090890ENST00000422869410398_421353.0574.0Zinc fingerC2H2-type 6
TgeneCTCFLchr20:58442765chr20:56090890ENST00000422869410428_451353.0574.0Zinc fingerC2H2-type 7
TgeneCTCFLchr20:58442765chr20:56090890ENST00000422869410458_480353.0574.0Zinc fingerC2H2-type 8
TgeneCTCFLchr20:58442765chr20:56090890ENST00000422869410486_508353.0574.0Zinc fingerC2H2-type 9
TgeneCTCFLchr20:58442765chr20:56090890ENST00000422869410514_537353.0574.0Zinc fingerC2H2-type 10
TgeneCTCFLchr20:58442765chr20:56090890ENST00000422869410546_568353.0574.0Zinc fingerC2H2-type 11%3B atypical
TgeneCTCFLchr20:58442765chr20:56090890ENST00000423479412370_392353.0701.0Zinc fingerC2H2-type 5
TgeneCTCFLchr20:58442765chr20:56090890ENST00000423479412398_421353.0701.0Zinc fingerC2H2-type 6
TgeneCTCFLchr20:58442765chr20:56090890ENST00000423479412428_451353.0701.0Zinc fingerC2H2-type 7
TgeneCTCFLchr20:58442765chr20:56090890ENST00000423479412458_480353.0701.0Zinc fingerC2H2-type 8
TgeneCTCFLchr20:58442765chr20:56090890ENST00000423479412486_508353.0701.0Zinc fingerC2H2-type 9
TgeneCTCFLchr20:58442765chr20:56090890ENST00000423479412514_537353.0701.0Zinc fingerC2H2-type 10
TgeneCTCFLchr20:58442765chr20:56090890ENST00000423479412546_568353.0701.0Zinc fingerC2H2-type 11%3B atypical
TgeneCTCFLchr20:58442765chr20:56090890ENST00000429804410370_392353.0614.0Zinc fingerC2H2-type 5
TgeneCTCFLchr20:58442765chr20:56090890ENST00000429804410398_421353.0614.0Zinc fingerC2H2-type 6
TgeneCTCFLchr20:58442765chr20:56090890ENST00000429804410428_451353.0614.0Zinc fingerC2H2-type 7
TgeneCTCFLchr20:58442765chr20:56090890ENST00000429804410458_480353.0614.0Zinc fingerC2H2-type 8
TgeneCTCFLchr20:58442765chr20:56090890ENST00000429804410486_508353.0614.0Zinc fingerC2H2-type 9
TgeneCTCFLchr20:58442765chr20:56090890ENST00000429804410514_537353.0614.0Zinc fingerC2H2-type 10
TgeneCTCFLchr20:58442765chr20:56090890ENST00000429804410546_568353.0614.0Zinc fingerC2H2-type 11%3B atypical
TgeneCTCFLchr20:58442765chr20:56090890ENST0000043225506257_2790484.0Zinc fingerC2H2-type 1
TgeneCTCFLchr20:58442765chr20:56090890ENST0000043225506285_3070484.0Zinc fingerC2H2-type 2
TgeneCTCFLchr20:58442765chr20:56090890ENST0000043225506313_3360484.0Zinc fingerC2H2-type 3
TgeneCTCFLchr20:58442765chr20:56090890ENST0000043225506342_3640484.0Zinc fingerC2H2-type 4
TgeneCTCFLchr20:58442765chr20:56090890ENST0000043225506370_3920484.0Zinc fingerC2H2-type 5
TgeneCTCFLchr20:58442765chr20:56090890ENST0000043225506398_4210484.0Zinc fingerC2H2-type 6
TgeneCTCFLchr20:58442765chr20:56090890ENST0000043225506428_4510484.0Zinc fingerC2H2-type 7
TgeneCTCFLchr20:58442765chr20:56090890ENST0000043225506458_4800484.0Zinc fingerC2H2-type 8
TgeneCTCFLchr20:58442765chr20:56090890ENST0000043225506486_5080484.0Zinc fingerC2H2-type 9
TgeneCTCFLchr20:58442765chr20:56090890ENST0000043225506514_5370484.0Zinc fingerC2H2-type 10
TgeneCTCFLchr20:58442765chr20:56090890ENST0000043225506546_5680484.0Zinc fingerC2H2-type 11%3B atypical
TgeneCTCFLchr20:58442765chr20:56090890ENST00000433949310257_279148.0461.0Zinc fingerC2H2-type 1
TgeneCTCFLchr20:58442765chr20:56090890ENST00000433949310285_307148.0461.0Zinc fingerC2H2-type 2
TgeneCTCFLchr20:58442765chr20:56090890ENST00000433949310313_336148.0461.0Zinc fingerC2H2-type 3
TgeneCTCFLchr20:58442765chr20:56090890ENST00000433949310342_364148.0461.0Zinc fingerC2H2-type 4
TgeneCTCFLchr20:58442765chr20:56090890ENST00000433949310370_392148.0461.0Zinc fingerC2H2-type 5
TgeneCTCFLchr20:58442765chr20:56090890ENST00000433949310398_421148.0461.0Zinc fingerC2H2-type 6
TgeneCTCFLchr20:58442765chr20:56090890ENST00000433949310428_451148.0461.0Zinc fingerC2H2-type 7
TgeneCTCFLchr20:58442765chr20:56090890ENST00000433949310458_480148.0461.0Zinc fingerC2H2-type 8
TgeneCTCFLchr20:58442765chr20:56090890ENST00000433949310486_508148.0461.0Zinc fingerC2H2-type 9
TgeneCTCFLchr20:58442765chr20:56090890ENST00000433949310514_537148.0461.0Zinc fingerC2H2-type 10
TgeneCTCFLchr20:58442765chr20:56090890ENST00000433949310546_568148.0461.0Zinc fingerC2H2-type 11%3B atypical
TgeneCTCFLchr20:58442765chr20:56090890ENST0000050268629257_27991.0404.0Zinc fingerC2H2-type 1
TgeneCTCFLchr20:58442765chr20:56090890ENST0000050268629285_30791.0404.0Zinc fingerC2H2-type 2
TgeneCTCFLchr20:58442765chr20:56090890ENST0000050268629313_33691.0404.0Zinc fingerC2H2-type 3
TgeneCTCFLchr20:58442765chr20:56090890ENST0000050268629342_36491.0404.0Zinc fingerC2H2-type 4
TgeneCTCFLchr20:58442765chr20:56090890ENST0000050268629370_39291.0404.0Zinc fingerC2H2-type 5
TgeneCTCFLchr20:58442765chr20:56090890ENST0000050268629398_42191.0404.0Zinc fingerC2H2-type 6
TgeneCTCFLchr20:58442765chr20:56090890ENST0000050268629428_45191.0404.0Zinc fingerC2H2-type 7
TgeneCTCFLchr20:58442765chr20:56090890ENST0000050268629458_48091.0404.0Zinc fingerC2H2-type 8
TgeneCTCFLchr20:58442765chr20:56090890ENST0000050268629486_50891.0404.0Zinc fingerC2H2-type 9
TgeneCTCFLchr20:58442765chr20:56090890ENST0000050268629514_53791.0404.0Zinc fingerC2H2-type 10
TgeneCTCFLchr20:58442765chr20:56090890ENST0000050268629546_56891.0404.0Zinc fingerC2H2-type 11%3B atypical
TgeneCTCFLchr20:58442765chr20:56090890ENST0000053938239257_279148.0423.0Zinc fingerC2H2-type 1
TgeneCTCFLchr20:58442765chr20:56090890ENST0000053938239285_307148.0423.0Zinc fingerC2H2-type 2
TgeneCTCFLchr20:58442765chr20:56090890ENST0000053938239313_336148.0423.0Zinc fingerC2H2-type 3
TgeneCTCFLchr20:58442765chr20:56090890ENST0000053938239342_364148.0423.0Zinc fingerC2H2-type 4
TgeneCTCFLchr20:58442765chr20:56090890ENST0000053938239370_392148.0423.0Zinc fingerC2H2-type 5
TgeneCTCFLchr20:58442765chr20:56090890ENST0000053938239398_421148.0423.0Zinc fingerC2H2-type 6
TgeneCTCFLchr20:58442765chr20:56090890ENST0000053938239428_451148.0423.0Zinc fingerC2H2-type 7
TgeneCTCFLchr20:58442765chr20:56090890ENST0000053938239458_480148.0423.0Zinc fingerC2H2-type 8
TgeneCTCFLchr20:58442765chr20:56090890ENST0000053938239486_508148.0423.0Zinc fingerC2H2-type 9
TgeneCTCFLchr20:58442765chr20:56090890ENST0000053938239514_537148.0423.0Zinc fingerC2H2-type 10
TgeneCTCFLchr20:58442765chr20:56090890ENST0000053938239546_568148.0423.0Zinc fingerC2H2-type 11%3B atypical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCTCFLchr20:58442765chr20:56090890ENST00000243914411257_279353.0664.0Zinc fingerC2H2-type 1
TgeneCTCFLchr20:58442765chr20:56090890ENST00000243914411285_307353.0664.0Zinc fingerC2H2-type 2
TgeneCTCFLchr20:58442765chr20:56090890ENST00000243914411313_336353.0664.0Zinc fingerC2H2-type 3
TgeneCTCFLchr20:58442765chr20:56090890ENST00000243914411342_364353.0664.0Zinc fingerC2H2-type 4
TgeneCTCFLchr20:58442765chr20:56090890ENST00000371196411257_279353.0664.0Zinc fingerC2H2-type 1
TgeneCTCFLchr20:58442765chr20:56090890ENST00000371196411285_307353.0664.0Zinc fingerC2H2-type 2
TgeneCTCFLchr20:58442765chr20:56090890ENST00000371196411313_336353.0664.0Zinc fingerC2H2-type 3
TgeneCTCFLchr20:58442765chr20:56090890ENST00000371196411342_364353.0664.0Zinc fingerC2H2-type 4
TgeneCTCFLchr20:58442765chr20:56090890ENST00000422869410257_279353.0574.0Zinc fingerC2H2-type 1
TgeneCTCFLchr20:58442765chr20:56090890ENST00000422869410285_307353.0574.0Zinc fingerC2H2-type 2
TgeneCTCFLchr20:58442765chr20:56090890ENST00000422869410313_336353.0574.0Zinc fingerC2H2-type 3
TgeneCTCFLchr20:58442765chr20:56090890ENST00000422869410342_364353.0574.0Zinc fingerC2H2-type 4
TgeneCTCFLchr20:58442765chr20:56090890ENST00000423479412257_279353.0701.0Zinc fingerC2H2-type 1
TgeneCTCFLchr20:58442765chr20:56090890ENST00000423479412285_307353.0701.0Zinc fingerC2H2-type 2
TgeneCTCFLchr20:58442765chr20:56090890ENST00000423479412313_336353.0701.0Zinc fingerC2H2-type 3
TgeneCTCFLchr20:58442765chr20:56090890ENST00000423479412342_364353.0701.0Zinc fingerC2H2-type 4
TgeneCTCFLchr20:58442765chr20:56090890ENST00000429804410257_279353.0614.0Zinc fingerC2H2-type 1
TgeneCTCFLchr20:58442765chr20:56090890ENST00000429804410285_307353.0614.0Zinc fingerC2H2-type 2
TgeneCTCFLchr20:58442765chr20:56090890ENST00000429804410313_336353.0614.0Zinc fingerC2H2-type 3
TgeneCTCFLchr20:58442765chr20:56090890ENST00000429804410342_364353.0614.0Zinc fingerC2H2-type 4


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SYCP2
CTCFL


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SYCP2-CTCFL


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SYCP2-CTCFL


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource