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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SYNPO2-TRIM24

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SYNPO2-TRIM24
	FusionPDB ID: 88478
	FusionGDB2.0 ID: 88478
		Hgene	Tgene
	Gene symbol	SYNPO2	TRIM24
	Gene ID	171024	8805
	Gene name	synaptopodin 2	tripartite motif containing 24
	Synonyms	-	PTC6\|RNF82\|TF1A\|TIF1\|TIF1A\|TIF1ALPHA\|hTIF1
	Cytomap	4q26	7q33-q34
	Type of gene	protein-coding	protein-coding
	Description	synaptopodin-2genethonin-2myopodin	transcription intermediary factor 1-alphaE3 ubiquitin-protein ligase TRIM24RING finger protein 82RING-type E3 ubiquitin transferase TIF1-alphaTIF1-alphatranscriptional intermediary factor 1
	Modification date	20200313	20200313
	UniProtAcc	.	O15164
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000307142, ENST00000429713, ENST00000434046, ENST00000448416,	ENST00000497516, ENST00000343526, ENST00000415680,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 5 X 5=175	10 X 9 X 7=630
	# samples	9	11
	** MAII score	log2(9/175*10)=-0.959358015502654 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/630*10)=-2.51784830486262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SYNPO2 [Title/Abstract] AND TRIM24 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SYNPO2(119810296)-TRIM24(138252226), # samples:2
Anticipated loss of major functional domain due to fusion event.	SYNPO2-TRIM24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SYNPO2-TRIM24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SYNPO2-TRIM24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SYNPO2-TRIM24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TRIM24	GO:0016567	protein ubiquitination	19556538
Tgene	TRIM24	GO:0071391	cellular response to estrogen stimulus	21164480

Fusion gene breakpoints across SYNPO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TRIM24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AN-A0FJ-01A	SYNPO2	chr4	119810296	+	TRIM24	chr7	138252226	+
ChimerDB4	BRCA	TCGA-AN-A0FJ	SYNPO2	chr4	119810296	+	TRIM24	chr7	138252225	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000307142	SYNPO2	chr4	119810296	+	ENST00000343526	TRIM24	chr7	138252226	+	6966	301	196	1923	575
ENST00000307142	SYNPO2	chr4	119810296	+	ENST00000415680	TRIM24	chr7	138252226	+	2558	301	196	1923	575
ENST00000448416	SYNPO2	chr4	119810296	+	ENST00000343526	TRIM24	chr7	138252226	+	6953	288	183	1910	575
ENST00000448416	SYNPO2	chr4	119810296	+	ENST00000415680	TRIM24	chr7	138252226	+	2545	288	183	1910	575
ENST00000429713	SYNPO2	chr4	119810296	+	ENST00000343526	TRIM24	chr7	138252226	+	6952	287	182	1909	575
ENST00000429713	SYNPO2	chr4	119810296	+	ENST00000415680	TRIM24	chr7	138252226	+	2544	287	182	1909	575
ENST00000434046	SYNPO2	chr4	119810296	+	ENST00000343526	TRIM24	chr7	138252226	+	6770	105	0	1727	575
ENST00000434046	SYNPO2	chr4	119810296	+	ENST00000415680	TRIM24	chr7	138252226	+	2362	105	0	1727	575
ENST00000307142	SYNPO2	chr4	119810296	+	ENST00000343526	TRIM24	chr7	138252225	+	6966	301	196	1923	575
ENST00000307142	SYNPO2	chr4	119810296	+	ENST00000415680	TRIM24	chr7	138252225	+	2558	301	196	1923	575
ENST00000448416	SYNPO2	chr4	119810296	+	ENST00000343526	TRIM24	chr7	138252225	+	6953	288	183	1910	575
ENST00000448416	SYNPO2	chr4	119810296	+	ENST00000415680	TRIM24	chr7	138252225	+	2545	288	183	1910	575
ENST00000429713	SYNPO2	chr4	119810296	+	ENST00000343526	TRIM24	chr7	138252225	+	6952	287	182	1909	575
ENST00000429713	SYNPO2	chr4	119810296	+	ENST00000415680	TRIM24	chr7	138252225	+	2544	287	182	1909	575
ENST00000434046	SYNPO2	chr4	119810296	+	ENST00000343526	TRIM24	chr7	138252225	+	6770	105	0	1727	575
ENST00000434046	SYNPO2	chr4	119810296	+	ENST00000415680	TRIM24	chr7	138252225	+	2362	105	0	1727	575

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000307142	ENST00000343526	SYNPO2	chr4	119810296	+	TRIM24	chr7	138252226	+	0.000377291	0.9996227
ENST00000307142	ENST00000415680	SYNPO2	chr4	119810296	+	TRIM24	chr7	138252226	+	0.001676403	0.9983236
ENST00000448416	ENST00000343526	SYNPO2	chr4	119810296	+	TRIM24	chr7	138252226	+	0.000377126	0.9996228
ENST00000448416	ENST00000415680	SYNPO2	chr4	119810296	+	TRIM24	chr7	138252226	+	0.001688363	0.99831164
ENST00000429713	ENST00000343526	SYNPO2	chr4	119810296	+	TRIM24	chr7	138252226	+	0.000376495	0.99962354
ENST00000429713	ENST00000415680	SYNPO2	chr4	119810296	+	TRIM24	chr7	138252226	+	0.001666121	0.9983339
ENST00000434046	ENST00000343526	SYNPO2	chr4	119810296	+	TRIM24	chr7	138252226	+	0.000338802	0.9996612
ENST00000434046	ENST00000415680	SYNPO2	chr4	119810296	+	TRIM24	chr7	138252226	+	0.001206736	0.99879324
ENST00000307142	ENST00000343526	SYNPO2	chr4	119810296	+	TRIM24	chr7	138252225	+	0.000377291	0.9996227
ENST00000307142	ENST00000415680	SYNPO2	chr4	119810296	+	TRIM24	chr7	138252225	+	0.001676403	0.9983236
ENST00000448416	ENST00000343526	SYNPO2	chr4	119810296	+	TRIM24	chr7	138252225	+	0.000377126	0.9996228
ENST00000448416	ENST00000415680	SYNPO2	chr4	119810296	+	TRIM24	chr7	138252225	+	0.001688363	0.99831164
ENST00000429713	ENST00000343526	SYNPO2	chr4	119810296	+	TRIM24	chr7	138252225	+	0.000376495	0.99962354
ENST00000429713	ENST00000415680	SYNPO2	chr4	119810296	+	TRIM24	chr7	138252225	+	0.001666121	0.9983339
ENST00000434046	ENST00000343526	SYNPO2	chr4	119810296	+	TRIM24	chr7	138252225	+	0.000338802	0.9996612
ENST00000434046	ENST00000415680	SYNPO2	chr4	119810296	+	TRIM24	chr7	138252225	+	0.001206736	0.99879324

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>88478_88478_1_SYNPO2-TRIM24_SYNPO2_chr4_119810296_ENST00000307142_TRIM24_chr7_138252225_ENST00000343526_length(amino acids)=575AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQA
IKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSN
RTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESD
EESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNG
GELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQ
DPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEF

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>88478_88478_2_SYNPO2-TRIM24_SYNPO2_chr4_119810296_ENST00000307142_TRIM24_chr7_138252225_ENST00000415680_length(amino acids)=575AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQA
IKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSN
RTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESD
EESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNG
GELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQ
DPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEF

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>88478_88478_3_SYNPO2-TRIM24_SYNPO2_chr4_119810296_ENST00000307142_TRIM24_chr7_138252226_ENST00000343526_length(amino acids)=575AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQA
IKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSN
RTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESD
EESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNG
GELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQ
DPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEF

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>88478_88478_4_SYNPO2-TRIM24_SYNPO2_chr4_119810296_ENST00000307142_TRIM24_chr7_138252226_ENST00000415680_length(amino acids)=575AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQA
IKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSN
RTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESD
EESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNG
GELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQ
DPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEF

--------------------------------------------------------------

>88478_88478_5_SYNPO2-TRIM24_SYNPO2_chr4_119810296_ENST00000429713_TRIM24_chr7_138252225_ENST00000343526_length(amino acids)=575AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQA
IKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSN
RTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESD
EESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNG
GELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQ
DPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEF

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>88478_88478_6_SYNPO2-TRIM24_SYNPO2_chr4_119810296_ENST00000429713_TRIM24_chr7_138252225_ENST00000415680_length(amino acids)=575AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQA
IKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSN
RTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESD
EESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNG
GELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQ
DPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEF

--------------------------------------------------------------

>88478_88478_7_SYNPO2-TRIM24_SYNPO2_chr4_119810296_ENST00000429713_TRIM24_chr7_138252226_ENST00000343526_length(amino acids)=575AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQA
IKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSN
RTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESD
EESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNG
GELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQ
DPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEF

--------------------------------------------------------------

>88478_88478_8_SYNPO2-TRIM24_SYNPO2_chr4_119810296_ENST00000429713_TRIM24_chr7_138252226_ENST00000415680_length(amino acids)=575AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQA
IKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSN
RTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESD
EESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNG
GELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQ
DPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEF

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>88478_88478_9_SYNPO2-TRIM24_SYNPO2_chr4_119810296_ENST00000434046_TRIM24_chr7_138252225_ENST00000343526_length(amino acids)=575AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQA
IKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSN
RTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESD
EESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNG
GELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQ
DPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEF

--------------------------------------------------------------

>88478_88478_10_SYNPO2-TRIM24_SYNPO2_chr4_119810296_ENST00000434046_TRIM24_chr7_138252225_ENST00000415680_length(amino acids)=575AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQA
IKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSN
RTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESD
EESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNG
GELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQ
DPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEF

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>88478_88478_11_SYNPO2-TRIM24_SYNPO2_chr4_119810296_ENST00000434046_TRIM24_chr7_138252226_ENST00000343526_length(amino acids)=575AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQA
IKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSN
RTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESD
EESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNG
GELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQ
DPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEF

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>88478_88478_12_SYNPO2-TRIM24_SYNPO2_chr4_119810296_ENST00000434046_TRIM24_chr7_138252226_ENST00000415680_length(amino acids)=575AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQA
IKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSN
RTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESD
EESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNG
GELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQ
DPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEF

--------------------------------------------------------------

>88478_88478_13_SYNPO2-TRIM24_SYNPO2_chr4_119810296_ENST00000448416_TRIM24_chr7_138252225_ENST00000343526_length(amino acids)=575AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQA
IKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSN
RTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESD
EESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNG
GELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQ
DPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEF

--------------------------------------------------------------

>88478_88478_14_SYNPO2-TRIM24_SYNPO2_chr4_119810296_ENST00000448416_TRIM24_chr7_138252225_ENST00000415680_length(amino acids)=575AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQA
IKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSN
RTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESD
EESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNG
GELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQ
DPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEF

--------------------------------------------------------------

>88478_88478_15_SYNPO2-TRIM24_SYNPO2_chr4_119810296_ENST00000448416_TRIM24_chr7_138252226_ENST00000343526_length(amino acids)=575AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQA
IKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSN
RTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESD
EESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNG
GELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQ
DPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEF

--------------------------------------------------------------

>88478_88478_16_SYNPO2-TRIM24_SYNPO2_chr4_119810296_ENST00000448416_TRIM24_chr7_138252226_ENST00000415680_length(amino acids)=575AA_BP=35
MGTGDFICISMTGGAPWGFRLQGGKEQKQPLQVAKQPPPRLINFQNHSPKPNGPVLPPHPQQLRYPPNQNIPRQAIKPNPLQMAFLAQQA
IKQWQISSGQGTPSTTNSTSSTPSSPTITSAAGYDGKAFGSPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSN
RTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESD
EESRPQNANYPRSILTSLLLNSSQSSTSEETVLRSDAPDSTGDQPGLHQDNSSNGKSEWLDPSQKSPLHVGETRKEDDPNEDWCAVCQNG
GELLCCEKCPKVFHLSCHVPTLTNFPSGEWICTFCRDLSKPEVEYDCDAPSHNSEKKKTEGLVKLTPIDKRKCERLLLFLYCHEMSLAFQ
DPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLENYFEELLKNLYPEKRFPKPEF

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:119810296/chr7:138252226)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	TRIM24 O15164
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). {ECO:0000250, ECO:0000269\|PubMed:16322096, ECO:0000269\|PubMed:19556538, ECO:0000269\|PubMed:21164480}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000343526

932_987

510.0

1051.0

Domain

Bromo

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000415680

932_987

476.0

1017.0

Domain

Bromo

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000343526

932_987

510.0

1051.0

Domain

Bromo

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000415680

932_987

476.0

1017.0

Domain

Bromo

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000343526

891_907

510.0

1051.0

Motif

Nuclear localization signal

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000415680

891_907

476.0

1017.0

Motif

Nuclear localization signal

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000343526

891_907

510.0

1051.0

Motif

Nuclear localization signal

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000415680

891_907

476.0

1017.0

Motif

Nuclear localization signal

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000343526

754_779

510.0

1051.0

Region

Note=Nuclear receptor binding site (NRBS)

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000415680

754_779

476.0

1017.0

Region

Note=Nuclear receptor binding site (NRBS)

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000343526

754_779

510.0

1051.0

Region

Note=Nuclear receptor binding site (NRBS)

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000415680

754_779

476.0

1017.0

Region

Note=Nuclear receptor binding site (NRBS)

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000343526

826_873

510.0

1051.0

Zinc finger

PHD-type

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000415680

826_873

476.0

1017.0

Zinc finger

PHD-type

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000343526

826_873

510.0

1051.0

Zinc finger

PHD-type

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000415680

826_873

476.0

1017.0

Zinc finger

PHD-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000307142

400_405

35.0

1262.0

Compositional bias

Note=Poly-Arg

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000307142

423_426

35.0

1262.0

Compositional bias

Note=Poly-Glu

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000307142

591_658

35.0

1262.0

Compositional bias

Note=Pro-rich

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000307142

756_818

35.0

1262.0

Compositional bias

Note=Pro-rich

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000307142

767_770

35.0

1262.0

Compositional bias

Note=Poly-Ser

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000429713

400_405

35.0

1094.0

Compositional bias

Note=Poly-Arg

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000429713

423_426

35.0

1094.0

Compositional bias

Note=Poly-Glu

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000429713

591_658

35.0

1094.0

Compositional bias

Note=Pro-rich

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000429713

756_818

35.0

1094.0

Compositional bias

Note=Pro-rich

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000429713

767_770

35.0

1094.0

Compositional bias

Note=Poly-Ser

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000434046

400_405

35.0

1110.0

Compositional bias

Note=Poly-Arg

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000434046

423_426

35.0

1110.0

Compositional bias

Note=Poly-Glu

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000434046

591_658

35.0

1110.0

Compositional bias

Note=Pro-rich

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000434046

756_818

35.0

1110.0

Compositional bias

Note=Pro-rich

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000434046

767_770

35.0

1110.0

Compositional bias

Note=Poly-Ser

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000307142

400_405

35.0

1262.0

Compositional bias

Note=Poly-Arg

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000307142

423_426

35.0

1262.0

Compositional bias

Note=Poly-Glu

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000307142

591_658

35.0

1262.0

Compositional bias

Note=Pro-rich

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000307142

756_818

35.0

1262.0

Compositional bias

Note=Pro-rich

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000307142

767_770

35.0

1262.0

Compositional bias

Note=Poly-Ser

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000429713

400_405

35.0

1094.0

Compositional bias

Note=Poly-Arg

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000429713

423_426

35.0

1094.0

Compositional bias

Note=Poly-Glu

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000429713

591_658

35.0

1094.0

Compositional bias

Note=Pro-rich

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000429713

756_818

35.0

1094.0

Compositional bias

Note=Pro-rich

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000429713

767_770

35.0

1094.0

Compositional bias

Note=Poly-Ser

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000434046

400_405

35.0

1110.0

Compositional bias

Note=Poly-Arg

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000434046

423_426

35.0

1110.0

Compositional bias

Note=Poly-Glu

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000434046

591_658

35.0

1110.0

Compositional bias

Note=Pro-rich

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000434046

756_818

35.0

1110.0

Compositional bias

Note=Pro-rich

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000434046

767_770

35.0

1110.0

Compositional bias

Note=Poly-Ser

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000307142

6_88

35.0

1262.0

Domain

PDZ

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000429713

6_88

35.0

1094.0

Domain

PDZ

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000434046

6_88

35.0

1110.0

Domain

PDZ

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000307142

6_88

35.0

1262.0

Domain

PDZ

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000429713

6_88

35.0

1094.0

Domain

PDZ

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000434046

6_88

35.0

1110.0

Domain

PDZ

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000307142

398_406

35.0

1262.0

Motif

Nuclear localization signal

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000307142

619_622

35.0

1262.0

Motif

PPPY motif

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000429713

398_406

35.0

1094.0

Motif

Nuclear localization signal

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000429713

619_622

35.0

1094.0

Motif

PPPY motif

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000434046

398_406

35.0

1110.0

Motif

Nuclear localization signal

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000434046

619_622

35.0

1110.0

Motif

PPPY motif

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000307142

398_406

35.0

1262.0

Motif

Nuclear localization signal

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000307142

619_622

35.0

1262.0

Motif

PPPY motif

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000429713

398_406

35.0

1094.0

Motif

Nuclear localization signal

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000429713

619_622

35.0

1094.0

Motif

PPPY motif

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000434046

398_406

35.0

1110.0

Motif

Nuclear localization signal

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000434046

619_622

35.0

1110.0

Motif

PPPY motif

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000307142

534_663

35.0

1262.0

Region

F-actin binding

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000307142

664_803

35.0

1262.0

Region

F-actin binding

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000307142

664_916

35.0

1262.0

Region

F-actin bundling activity

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000307142

751_900

35.0

1262.0

Region

Actin binding

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000429713

534_663

35.0

1094.0

Region

F-actin binding

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000429713

664_803

35.0

1094.0

Region

F-actin binding

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000429713

664_916

35.0

1094.0

Region

F-actin bundling activity

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000429713

751_900

35.0

1094.0

Region

Actin binding

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000434046

534_663

35.0

1110.0

Region

F-actin binding

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000434046

664_803

35.0

1110.0

Region

F-actin binding

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000434046

664_916

35.0

1110.0

Region

F-actin bundling activity

Hgene

SYNPO2

chr4:119810296

chr7:138252225

ENST00000434046

751_900

35.0

1110.0

Region

Actin binding

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000307142

534_663

35.0

1262.0

Region

F-actin binding

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000307142

664_803

35.0

1262.0

Region

F-actin binding

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000307142

664_916

35.0

1262.0

Region

F-actin bundling activity

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000307142

751_900

35.0

1262.0

Region

Actin binding

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000429713

534_663

35.0

1094.0

Region

F-actin binding

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000429713

664_803

35.0

1094.0

Region

F-actin binding

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000429713

664_916

35.0

1094.0

Region

F-actin bundling activity

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000429713

751_900

35.0

1094.0

Region

Actin binding

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000434046

534_663

35.0

1110.0

Region

F-actin binding

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000434046

664_803

35.0

1110.0

Region

F-actin binding

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000434046

664_916

35.0

1110.0

Region

F-actin bundling activity

Hgene

SYNPO2

chr4:119810296

chr7:138252226

ENST00000434046

751_900

35.0

1110.0

Region

Actin binding

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000343526

289_359

510.0

1051.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000415680

289_359

476.0

1017.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000343526

289_359

510.0

1051.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000415680

289_359

476.0

1017.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000343526

344_347

510.0

1051.0

Compositional bias

Note=Poly-Gln

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000343526

9_15

510.0

1051.0

Compositional bias

Note=Poly-Ala

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000415680

344_347

476.0

1017.0

Compositional bias

Note=Poly-Gln

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000415680

9_15

476.0

1017.0

Compositional bias

Note=Poly-Ala

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000343526

344_347

510.0

1051.0

Compositional bias

Note=Poly-Gln

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000343526

9_15

510.0

1051.0

Compositional bias

Note=Poly-Ala

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000415680

344_347

476.0

1017.0

Compositional bias

Note=Poly-Gln

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000415680

9_15

476.0

1017.0

Compositional bias

Note=Poly-Ala

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000343526

158_211

510.0

1051.0

Zinc finger

B box-type 1

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000343526

218_259

510.0

1051.0

Zinc finger

B box-type 2

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000343526

56_82

510.0

1051.0

Zinc finger

RING-type

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000415680

158_211

476.0

1017.0

Zinc finger

B box-type 1

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000415680

218_259

476.0

1017.0

Zinc finger

B box-type 2

Tgene

TRIM24

chr4:119810296

chr7:138252225

ENST00000415680

56_82

476.0

1017.0

Zinc finger

RING-type

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000343526

158_211

510.0

1051.0

Zinc finger

B box-type 1

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000343526

218_259

510.0

1051.0

Zinc finger

B box-type 2

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000343526

56_82

510.0

1051.0

Zinc finger

RING-type

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000415680

158_211

476.0

1017.0

Zinc finger

B box-type 1

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000415680

218_259

476.0

1017.0

Zinc finger

B box-type 2

Tgene

TRIM24

chr4:119810296

chr7:138252226

ENST00000415680

56_82

476.0

1017.0

Zinc finger

RING-type

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

TRIM24

ZNF10, TRIM28, TRIM24, PML, NR3C2, ESR1, THRA, RARA, RXRA, NR3C1, AR, TRIM33, GTF2E1, TAF7, TAF11, UBE2U, ATF4, NFE2L2, STAT6, FOSL1, ESR2, PPARG, TP53, BRD7, HIST1H3A, HIST1H3D, HIST1H3C, HIST1H3E, HIST1H3I, HIST1H3G, HIST1H3J, HIST1H3H, HIST1H3B, HIST1H3F, HIST2H4B, HIST1H4I, HIST1H4A, HIST1H4D, HIST1H4F, HIST1H4K, HIST1H4C, HIST1H4H, HIST1H4B, HIST1H4E, HIST1H4L, HIST2H4A, HIST1H4J, HIST4H4, NCOA1, NONO, CDK12, SNRPA, SF3B2, SF3B1, RNF141, RNF181, TRIM8, BRCA1, RNF2, MAGEA10, RFPL4B, QPRT, HSPB1, NTRK1, MUS81, PTEN, TCF4, FOXI1, USP37, NANOG, ZNF264, ZNF483, ZNF324B, WDYHV1, ZNF695, ZIM2, SYCE3, ZNF764, ZNF785, ZNF331, ZNF133, ZNF254, ZNF550, CDC16, CNKSR1, MTNR1B, DTNBP1, STAT3, NR1I3, SOX2, TNRC6A, UBE2I, MYC, MCM2, SUPT6H, MCM4, PEX5, MCM6, MCM7, SUPT16H, SSRP1, SPOP, FBXO38, PLEKHA4, CREBBP, SMG7, H2AFY, NPM1, H2AFY2, BRD2, SET, ZC3H18, RSF1, MBD1, E2F2, TOP2A, BRPF1, AFF4, PADI2, TFDP2, ZCCHC8, MLKL, PPIH, TFDP1, VPS72, ENPP6, GADD45GIP1, SEZ6L, RAD18, PSD, CDH16, YEATS4, DSC2, MLLT1, RNF43, C10orf71, RCOR2, TANC1, ACTR6, RIBC2, FMN2, RBM7, NOLC1, SRCAP, RNPS1, XPC, MFAP1, DNASE2B, XPO1, TRAF3, UBE2D1, DNAJC19, CEP78, CALM1, SUMO2, SOD1, MARCKS, CALR, PDIA4, DPP7, PTMA, RPS28, PDIA3, HSPE1, CSTB, ALDOA, MOB2, MIF, DDTL, RPRD1B, TPM3, CYCS, STMN1, BASP1, SSB, LCE3D, PGK1, PFN1, TKT, NPC2, PA2G4, TAB1, MARCKSL1, CNPY2, MYL12B, ARHGDIA, MTPN, TPI1, MDH1, PGAM1, TBCA, HMGN1, GGH, PTMS, HSP90B1, MAT2A, ANXA5, PPIB, FABP5, PDIA6, DDX39B, CMBL, TALDO1, TPM4, NUDC, CKB, NUCKS1, GSTO1, HDGF, TAGLN2, PRDX5, PARK7, PEBP1, MYL6, AHSG, SOD2, TRIM37, APEX1, ASF1A, CBX3, HIST1H2BG, TERF2IP, ZNF330, HORMAD2, MAD2L1, ZNF418, ZNF776, CRYAA, ZNF287, ABTB2, CCT8L2, ZNF17, ZNF718, ZNF484, KRT37, NUP62, PIAS4, KXD1, KNSTRN, MAGEA9, NUP62CL, ZNF726, LURAP1, ZNF383, KRT39, TGM7, ZNF460, ZNF543, KRT38, TRIM52, NLRP3, T, ELF1, ELF3, ELF4, ELF5, ERG, ETS1, ETV4, FEV, FOS, GATA2, HNF1B, HNF4A, KLF15, KLF5, KLF6, KLF8, LHX1, LHX2, LHX3, LHX4, MYOD1, NFIC, NFIX, PAX6, SOX17, SOX5, SP7, TLX3, YY1,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SYNPO2
TRIM24

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000307142	+	1	5	481_663	35.0	1262.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000307142	+	1	5	664_924	35.0	1262.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000307142	+	1	5	901_1093	35.0	1262.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000429713	+	1	4	481_663	35.0	1094.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000429713	+	1	4	664_924	35.0	1094.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000429713	+	1	4	901_1093	35.0	1094.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000434046	+	1	5	481_663	35.0	1110.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000434046	+	1	5	664_924	35.0	1110.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000434046	+	1	5	901_1093	35.0	1110.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000307142	+	1	5	481_663	35.0	1262.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000307142	+	1	5	664_924	35.0	1262.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000307142	+	1	5	901_1093	35.0	1262.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000429713	+	1	4	481_663	35.0	1094.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000429713	+	1	4	664_924	35.0	1094.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000429713	+	1	4	901_1093	35.0	1094.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000434046	+	1	5	481_663	35.0	1110.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000434046	+	1	5	664_924	35.0	1110.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000434046	+	1	5	901_1093	35.0	1110.0	ACTN2
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000307142	+	1	5	615_626	35.0	1262.0	BAG3
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000429713	+	1	4	615_626	35.0	1094.0	BAG3
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000434046	+	1	5	615_626	35.0	1110.0	BAG3
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000307142	+	1	5	615_626	35.0	1262.0	BAG3
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000429713	+	1	4	615_626	35.0	1094.0	BAG3
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000434046	+	1	5	615_626	35.0	1110.0	BAG3
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000307142	+	1	5	810_1093	35.0	1262.0	FLNC
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000429713	+	1	4	810_1093	35.0	1094.0	FLNC
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000434046	+	1	5	810_1093	35.0	1110.0	FLNC
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000307142	+	1	5	810_1093	35.0	1262.0	FLNC
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000429713	+	1	4	810_1093	35.0	1094.0	FLNC
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000434046	+	1	5	810_1093	35.0	1110.0	FLNC
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000307142	+	1	5	1_180	35.0	1262.0	VPS18
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000429713	+	1	4	1_180	35.0	1094.0	VPS18
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000434046	+	1	5	1_180	35.0	1110.0	VPS18
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000307142	+	1	5	1_180	35.0	1262.0	VPS18
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000429713	+	1	4	1_180	35.0	1094.0	VPS18
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000434046	+	1	5	1_180	35.0	1110.0	VPS18
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000307142	+	1	5	607_811	35.0	1262.0	YWHAB
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000429713	+	1	4	607_811	35.0	1094.0	YWHAB
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000434046	+	1	5	607_811	35.0	1110.0	YWHAB
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000307142	+	1	5	607_811	35.0	1262.0	YWHAB
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000429713	+	1	4	607_811	35.0	1094.0	YWHAB
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000434046	+	1	5	607_811	35.0	1110.0	YWHAB
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000307142	+	1	5	1000_1019	35.0	1262.0	ZYX
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000429713	+	1	4	1000_1019	35.0	1094.0	ZYX
Hgene	SYNPO2	chr4:119810296	chr7:138252225	ENST00000434046	+	1	5	1000_1019	35.0	1110.0	ZYX
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000307142	+	1	5	1000_1019	35.0	1262.0	ZYX
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000429713	+	1	4	1000_1019	35.0	1094.0	ZYX
Hgene	SYNPO2	chr4:119810296	chr7:138252226	ENST00000434046	+	1	5	1000_1019	35.0	1110.0	ZYX

Top

Related Drugs to SYNPO2-TRIM24

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to SYNPO2-TRIM24

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	TRIM24	C0238463	Papillary thyroid carcinoma	2	ORPHANET
Tgene	TRIM24	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene	TRIM24	C2239176	Liver carcinoma	1	CTD_human
Tgene	TRIM24	C3658266	Prostatic Cancer, Castration-Resistant	1	CTD_human
Tgene	TRIM24	C3658267	Prostatic Neoplasms, Castration-Resistant	1	CTD_human