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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TAF4B-CHST9

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TAF4B-CHST9
	FusionPDB ID: 88792
	FusionGDB2.0 ID: 88792
		Hgene	Tgene
	Gene symbol	TAF4B	CHST9
	Gene ID	493913	83539
	Gene name	PAPPA antisense RNA 1	carbohydrate sulfotransferase 9
	Synonyms	DIPAS\|NCRNA00156\|PAPPA-AS\|PAPPAAS\|PAPPAS\|TAF2C2\|TAF4B\|TAFII105	GALNAC4ST-2\|GalNAc4ST2
	Cytomap	9q33.1	18q11.2
	Type of gene	ncRNA	protein-coding
	Description	DIPLA1-antisense expressedPAPPA antisense RNA 1 (non-protein coding)PAPPA antisense RNA 1 (tail to tail)	carbohydrate sulfotransferase 9GalNAc-4-sulfotransferase 2N-acetylgalactosamine 4-O-sulfotransferase 2carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9galNAc-4-O-sulfotransferase 2
	Modification date	20200313	20200313
	UniProtAcc	.	Q7L1S5
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000269142, ENST00000400466, ENST00000578121,	ENST00000284224, ENST00000580774, ENST00000581714,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 4 X 2=32	12 X 11 X 6=792
	# samples	4	14
	** MAII score	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(14/792*10)=-2.50007360313464 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TAF4B [Title/Abstract] AND CHST9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TAF4B(23807240)-CHST9(24628467), # samples:2
Anticipated loss of major functional domain due to fusion event.	TAF4B-CHST9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TAF4B-CHST9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CHST9	GO:0006790	sulfur compound metabolic process	11445554

Fusion gene breakpoints across TAF4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CHST9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A2-A0YM-01A	TAF4B	chr18	23807240	-	CHST9	chr18	24628467	-
ChimerDB4	BRCA	TCGA-A2-A0YM	TAF4B	chr18	23807240	+	CHST9	chr18	24628467	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000269142	TAF4B	chr18	23807240	+	ENST00000284224	CHST9	chr18	24628467	-	3180	1341	923	2551	542
ENST00000269142	TAF4B	chr18	23807240	+	ENST00000581714	CHST9	chr18	24628467	-	3034	1341	923	2551	542
ENST00000269142	TAF4B	chr18	23807240	+	ENST00000580774	CHST9	chr18	24628467	-	2994	1341	1407	2513	368
ENST00000400466	TAF4B	chr18	23807240	+	ENST00000284224	CHST9	chr18	24628467	-	2671	832	414	2042	542
ENST00000400466	TAF4B	chr18	23807240	+	ENST00000581714	CHST9	chr18	24628467	-	2525	832	414	2042	542
ENST00000400466	TAF4B	chr18	23807240	+	ENST00000580774	CHST9	chr18	24628467	-	2485	832	898	2004	368
ENST00000578121	TAF4B	chr18	23807240	+	ENST00000284224	CHST9	chr18	24628467	-	2630	791	373	2001	542
ENST00000578121	TAF4B	chr18	23807240	+	ENST00000581714	CHST9	chr18	24628467	-	2484	791	373	2001	542
ENST00000578121	TAF4B	chr18	23807240	+	ENST00000580774	CHST9	chr18	24628467	-	2444	791	857	1963	368

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000269142	ENST00000284224	TAF4B	chr18	23807240	+	CHST9	chr18	24628467	-	0.002326649	0.99767333
ENST00000269142	ENST00000581714	TAF4B	chr18	23807240	+	CHST9	chr18	24628467	-	0.002452077	0.9975479
ENST00000269142	ENST00000580774	TAF4B	chr18	23807240	+	CHST9	chr18	24628467	-	0.001507128	0.99849284
ENST00000400466	ENST00000284224	TAF4B	chr18	23807240	+	CHST9	chr18	24628467	-	0.002620511	0.99737954
ENST00000400466	ENST00000581714	TAF4B	chr18	23807240	+	CHST9	chr18	24628467	-	0.002783736	0.9972162
ENST00000400466	ENST00000580774	TAF4B	chr18	23807240	+	CHST9	chr18	24628467	-	0.001640548	0.9983594
ENST00000578121	ENST00000284224	TAF4B	chr18	23807240	+	CHST9	chr18	24628467	-	0.002578416	0.9974216
ENST00000578121	ENST00000581714	TAF4B	chr18	23807240	+	CHST9	chr18	24628467	-	0.002724886	0.9972752
ENST00000578121	ENST00000580774	TAF4B	chr18	23807240	+	CHST9	chr18	24628467	-	0.001618307	0.99838173

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>88792_88792_1_TAF4B-CHST9_TAF4B_chr18_23807240_ENST00000269142_CHST9_chr18_24628467_ENST00000284224_length(amino acids)=542AA_BP=139
MPRAKPPLTSAPGTAAPKLPLSPWGMPAGLTEPAGAAPPAAVSASGTVTMAPAGALPVRVESTPVALGAVTKAPVSVCVEPTASQPLRSP
VGTLVTKVAPVSAPPKVSSGPRLPAPQIVAVKAPNTTTIQFPANLQLPPGRVEKRREQKVTSGWGPVKYLRPVPRIMSTEKIQEHITNQN
PKFHMPEDVREKKENLLLNSERSTRLLTKTSHSQGGDQALSKSTGSPTEKLIEKRQGAKTVFNKFSNMNWPVDIHPLNKSLVKDNKWKKT
EETQEKRRSFLQEFCKKYGGVSHHQSHLFHTVSRIYVEDKHKILYCEVPKAGCSNWKRILMVLNGLASSAYNISHNAVHYGKHLKKLDSF
DLKGIYTRLNTYTKAVFVRDPMERLVSAFRDKFEHPNSYYHPVFGKAIIKKYRPNACEEALINGSGVKFKEFIHYLLDSHRPVGMDIHWE
KVSKLCYPCLINYDFVGKFETLEEDANYFLQMIGAPKELKFPNFKDRHSSDERTNAQVVRQYLKDLTRTERQLIYDFYYLDYLMFNYTTP

--------------------------------------------------------------

>88792_88792_2_TAF4B-CHST9_TAF4B_chr18_23807240_ENST00000269142_CHST9_chr18_24628467_ENST00000580774_length(amino acids)=368AA_BP=
MYPESNPKFHMPEDVREKKENLLLNSERSTRLLTKTSHSQGGDQALSKSTGSPTEKLIEKRQGAKTVFNKFSNMNWPVDIHPLNKSLVKD
NKWKKTEETQEKRRSFLQEFCKKYGGVSHHQSHLFHTVSRIYVEDKHKILYCEVPKAGCSNWKRILMVLNGLASSAYNISHNAVHYGKHL
KKLDSFDLKGIYTRLNTYTKAVFVRDPMERLVSAFRDKFEHPNSYYHPVFGKAIIKKYRPNACEEALINGSGVKFKEFIHYLLDSHRPVG
MDIHWEKVSKLCYPCLINYDFVGKFETLEEDANYFLQMIGAPKELKFPNFKDRHSSDERTNAQVVRQYLKDLTRTERQLIYDFYYLDYLM

--------------------------------------------------------------

>88792_88792_3_TAF4B-CHST9_TAF4B_chr18_23807240_ENST00000269142_CHST9_chr18_24628467_ENST00000581714_length(amino acids)=542AA_BP=139
MPRAKPPLTSAPGTAAPKLPLSPWGMPAGLTEPAGAAPPAAVSASGTVTMAPAGALPVRVESTPVALGAVTKAPVSVCVEPTASQPLRSP
VGTLVTKVAPVSAPPKVSSGPRLPAPQIVAVKAPNTTTIQFPANLQLPPGRVEKRREQKVTSGWGPVKYLRPVPRIMSTEKIQEHITNQN
PKFHMPEDVREKKENLLLNSERSTRLLTKTSHSQGGDQALSKSTGSPTEKLIEKRQGAKTVFNKFSNMNWPVDIHPLNKSLVKDNKWKKT
EETQEKRRSFLQEFCKKYGGVSHHQSHLFHTVSRIYVEDKHKILYCEVPKAGCSNWKRILMVLNGLASSAYNISHNAVHYGKHLKKLDSF
DLKGIYTRLNTYTKAVFVRDPMERLVSAFRDKFEHPNSYYHPVFGKAIIKKYRPNACEEALINGSGVKFKEFIHYLLDSHRPVGMDIHWE
KVSKLCYPCLINYDFVGKFETLEEDANYFLQMIGAPKELKFPNFKDRHSSDERTNAQVVRQYLKDLTRTERQLIYDFYYLDYLMFNYTTP

--------------------------------------------------------------

>88792_88792_4_TAF4B-CHST9_TAF4B_chr18_23807240_ENST00000400466_CHST9_chr18_24628467_ENST00000284224_length(amino acids)=542AA_BP=139
MPRAKPPLTSAPGTAAPKLPLSPWGMPAGLTEPAGAAPPAAVSASGTVTMAPAGALPVRVESTPVALGAVTKAPVSVCVEPTASQPLRSP
VGTLVTKVAPVSAPPKVSSGPRLPAPQIVAVKAPNTTTIQFPANLQLPPGRVEKRREQKVTSGWGPVKYLRPVPRIMSTEKIQEHITNQN
PKFHMPEDVREKKENLLLNSERSTRLLTKTSHSQGGDQALSKSTGSPTEKLIEKRQGAKTVFNKFSNMNWPVDIHPLNKSLVKDNKWKKT
EETQEKRRSFLQEFCKKYGGVSHHQSHLFHTVSRIYVEDKHKILYCEVPKAGCSNWKRILMVLNGLASSAYNISHNAVHYGKHLKKLDSF
DLKGIYTRLNTYTKAVFVRDPMERLVSAFRDKFEHPNSYYHPVFGKAIIKKYRPNACEEALINGSGVKFKEFIHYLLDSHRPVGMDIHWE
KVSKLCYPCLINYDFVGKFETLEEDANYFLQMIGAPKELKFPNFKDRHSSDERTNAQVVRQYLKDLTRTERQLIYDFYYLDYLMFNYTTP

--------------------------------------------------------------

>88792_88792_5_TAF4B-CHST9_TAF4B_chr18_23807240_ENST00000400466_CHST9_chr18_24628467_ENST00000580774_length(amino acids)=368AA_BP=
MYPESNPKFHMPEDVREKKENLLLNSERSTRLLTKTSHSQGGDQALSKSTGSPTEKLIEKRQGAKTVFNKFSNMNWPVDIHPLNKSLVKD
NKWKKTEETQEKRRSFLQEFCKKYGGVSHHQSHLFHTVSRIYVEDKHKILYCEVPKAGCSNWKRILMVLNGLASSAYNISHNAVHYGKHL
KKLDSFDLKGIYTRLNTYTKAVFVRDPMERLVSAFRDKFEHPNSYYHPVFGKAIIKKYRPNACEEALINGSGVKFKEFIHYLLDSHRPVG
MDIHWEKVSKLCYPCLINYDFVGKFETLEEDANYFLQMIGAPKELKFPNFKDRHSSDERTNAQVVRQYLKDLTRTERQLIYDFYYLDYLM

--------------------------------------------------------------

>88792_88792_6_TAF4B-CHST9_TAF4B_chr18_23807240_ENST00000400466_CHST9_chr18_24628467_ENST00000581714_length(amino acids)=542AA_BP=139
MPRAKPPLTSAPGTAAPKLPLSPWGMPAGLTEPAGAAPPAAVSASGTVTMAPAGALPVRVESTPVALGAVTKAPVSVCVEPTASQPLRSP
VGTLVTKVAPVSAPPKVSSGPRLPAPQIVAVKAPNTTTIQFPANLQLPPGRVEKRREQKVTSGWGPVKYLRPVPRIMSTEKIQEHITNQN
PKFHMPEDVREKKENLLLNSERSTRLLTKTSHSQGGDQALSKSTGSPTEKLIEKRQGAKTVFNKFSNMNWPVDIHPLNKSLVKDNKWKKT
EETQEKRRSFLQEFCKKYGGVSHHQSHLFHTVSRIYVEDKHKILYCEVPKAGCSNWKRILMVLNGLASSAYNISHNAVHYGKHLKKLDSF
DLKGIYTRLNTYTKAVFVRDPMERLVSAFRDKFEHPNSYYHPVFGKAIIKKYRPNACEEALINGSGVKFKEFIHYLLDSHRPVGMDIHWE
KVSKLCYPCLINYDFVGKFETLEEDANYFLQMIGAPKELKFPNFKDRHSSDERTNAQVVRQYLKDLTRTERQLIYDFYYLDYLMFNYTTP

--------------------------------------------------------------

>88792_88792_7_TAF4B-CHST9_TAF4B_chr18_23807240_ENST00000578121_CHST9_chr18_24628467_ENST00000284224_length(amino acids)=542AA_BP=139
MPRAKPPLTSAPGTAAPKLPLSPWGMPAGLTEPAGAAPPAAVSASGTVTMAPAGALPVRVESTPVALGAVTKAPVSVCVEPTASQPLRSP
VGTLVTKVAPVSAPPKVSSGPRLPAPQIVAVKAPNTTTIQFPANLQLPPGRVEKRREQKVTSGWGPVKYLRPVPRIMSTEKIQEHITNQN
PKFHMPEDVREKKENLLLNSERSTRLLTKTSHSQGGDQALSKSTGSPTEKLIEKRQGAKTVFNKFSNMNWPVDIHPLNKSLVKDNKWKKT
EETQEKRRSFLQEFCKKYGGVSHHQSHLFHTVSRIYVEDKHKILYCEVPKAGCSNWKRILMVLNGLASSAYNISHNAVHYGKHLKKLDSF
DLKGIYTRLNTYTKAVFVRDPMERLVSAFRDKFEHPNSYYHPVFGKAIIKKYRPNACEEALINGSGVKFKEFIHYLLDSHRPVGMDIHWE
KVSKLCYPCLINYDFVGKFETLEEDANYFLQMIGAPKELKFPNFKDRHSSDERTNAQVVRQYLKDLTRTERQLIYDFYYLDYLMFNYTTP

--------------------------------------------------------------

>88792_88792_8_TAF4B-CHST9_TAF4B_chr18_23807240_ENST00000578121_CHST9_chr18_24628467_ENST00000580774_length(amino acids)=368AA_BP=
MYPESNPKFHMPEDVREKKENLLLNSERSTRLLTKTSHSQGGDQALSKSTGSPTEKLIEKRQGAKTVFNKFSNMNWPVDIHPLNKSLVKD
NKWKKTEETQEKRRSFLQEFCKKYGGVSHHQSHLFHTVSRIYVEDKHKILYCEVPKAGCSNWKRILMVLNGLASSAYNISHNAVHYGKHL
KKLDSFDLKGIYTRLNTYTKAVFVRDPMERLVSAFRDKFEHPNSYYHPVFGKAIIKKYRPNACEEALINGSGVKFKEFIHYLLDSHRPVG
MDIHWEKVSKLCYPCLINYDFVGKFETLEEDANYFLQMIGAPKELKFPNFKDRHSSDERTNAQVVRQYLKDLTRTERQLIYDFYYLDYLM

--------------------------------------------------------------

>88792_88792_9_TAF4B-CHST9_TAF4B_chr18_23807240_ENST00000578121_CHST9_chr18_24628467_ENST00000581714_length(amino acids)=542AA_BP=139
MPRAKPPLTSAPGTAAPKLPLSPWGMPAGLTEPAGAAPPAAVSASGTVTMAPAGALPVRVESTPVALGAVTKAPVSVCVEPTASQPLRSP
VGTLVTKVAPVSAPPKVSSGPRLPAPQIVAVKAPNTTTIQFPANLQLPPGRVEKRREQKVTSGWGPVKYLRPVPRIMSTEKIQEHITNQN
PKFHMPEDVREKKENLLLNSERSTRLLTKTSHSQGGDQALSKSTGSPTEKLIEKRQGAKTVFNKFSNMNWPVDIHPLNKSLVKDNKWKKT
EETQEKRRSFLQEFCKKYGGVSHHQSHLFHTVSRIYVEDKHKILYCEVPKAGCSNWKRILMVLNGLASSAYNISHNAVHYGKHLKKLDSF
DLKGIYTRLNTYTKAVFVRDPMERLVSAFRDKFEHPNSYYHPVFGKAIIKKYRPNACEEALINGSGVKFKEFIHYLLDSHRPVGMDIHWE
KVSKLCYPCLINYDFVGKFETLEEDANYFLQMIGAPKELKFPNFKDRHSSDERTNAQVVRQYLKDLTRTERQLIYDFYYLDYLMFNYTTP

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:23807240/chr18:24628467)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CHST9 Q7L1S5
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CHST9

chr18:23807240

chr18:24628467

ENST00000284224

220_226

40.333333333333336

444.0

Nucleotide binding

PAPS

Tgene

CHST9

chr18:23807240

chr18:24628467

ENST00000284224

280_288

40.333333333333336

444.0

Nucleotide binding

PAPS

Tgene

CHST9

chr18:23807240

chr18:24628467

ENST00000580774

220_226

40.333333333333336

75.0

Nucleotide binding

PAPS

Tgene

CHST9

chr18:23807240

chr18:24628467

ENST00000580774

280_288

40.333333333333336

75.0

Nucleotide binding

PAPS

Tgene

CHST9

chr18:23807240

chr18:24628467

ENST00000581714

220_226

40.333333333333336

444.0

Nucleotide binding

PAPS

Tgene

CHST9

chr18:23807240

chr18:24628467

ENST00000581714

280_288

40.333333333333336

444.0

Nucleotide binding

PAPS

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TAF4B

chr18:23807240

chr18:24628467

ENST00000269142

722_787

114.33333333333333

863.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TAF4B

chr18:23807240

chr18:24628467

ENST00000400466

722_787

114.33333333333333

619.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TAF4B

chr18:23807240

chr18:24628467

ENST00000269142

256_353

114.33333333333333

863.0

Domain

TAFH

Hgene

TAF4B

chr18:23807240

chr18:24628467

ENST00000269142

653_702

114.33333333333333

863.0

Domain

Note=Histone-fold

Hgene

TAF4B

chr18:23807240

chr18:24628467

ENST00000400466

256_353

114.33333333333333

619.0

Domain

TAFH

Hgene

TAF4B

chr18:23807240

chr18:24628467

ENST00000400466

653_702

114.33333333333333

619.0

Domain

Note=Histone-fold

Hgene

TAF4B

chr18:23807240

chr18:24628467

ENST00000269142

516_556

114.33333333333333

863.0

Motif

Note=Nuclear export signal

Hgene

TAF4B

chr18:23807240

chr18:24628467

ENST00000400466

516_556

114.33333333333333

619.0

Motif

Note=Nuclear export signal

Tgene

CHST9

chr18:23807240

chr18:24628467

ENST00000284224

1_12

40.333333333333336

444.0

Topological domain

Cytoplasmic

Tgene

CHST9

chr18:23807240

chr18:24628467

ENST00000284224

34_443

40.333333333333336

444.0

Topological domain

Lumenal

Tgene

CHST9

chr18:23807240

chr18:24628467

ENST00000580774

1_12

40.333333333333336

75.0

Topological domain

Cytoplasmic

Tgene

CHST9

chr18:23807240

chr18:24628467

ENST00000580774

34_443

40.333333333333336

75.0

Topological domain

Lumenal

Tgene

CHST9

chr18:23807240

chr18:24628467

ENST00000581714

1_12

40.333333333333336

444.0

Topological domain

Cytoplasmic

Tgene

CHST9

chr18:23807240

chr18:24628467

ENST00000581714

34_443

40.333333333333336

444.0

Topological domain

Lumenal

Tgene

CHST9

chr18:23807240

chr18:24628467

ENST00000284224

13_33

40.333333333333336

444.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

CHST9

chr18:23807240

chr18:24628467

ENST00000580774

13_33

40.333333333333336

75.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

CHST9

chr18:23807240

chr18:24628467

ENST00000581714

13_33

40.333333333333336

444.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1159_TAF4B_23807240_CHST9_24628467_1159_TAF4B_23807240_CHST9_24628467_ranked_0.pdb	TAF4B	23807240	23807240	ENST00000580774	CHST9	chr18	24628467	-	MPRAKPPLTSAPGTAAPKLPLSPWGMPAGLTEPAGAAPPAAVSASGTVTMAPAGALPVRVESTPVALGAVTKAPVSVCVEPTASQPLRSP VGTLVTKVAPVSAPPKVSSGPRLPAPQIVAVKAPNTTTIQFPANLQLPPGRVEKRREQKVTSGWGPVKYLRPVPRIMSTEKIQEHITNQN PKFHMPEDVREKKENLLLNSERSTRLLTKTSHSQGGDQALSKSTGSPTEKLIEKRQGAKTVFNKFSNMNWPVDIHPLNKSLVKDNKWKKT EETQEKRRSFLQEFCKKYGGVSHHQSHLFHTVSRIYVEDKHKILYCEVPKAGCSNWKRILMVLNGLASSAYNISHNAVHYGKHLKKLDSF DLKGIYTRLNTYTKAVFVRDPMERLVSAFRDKFEHPNSYYHPVFGKAIIKKYRPNACEEALINGSGVKFKEFIHYLLDSHRPVGMDIHWE KVSKLCYPCLINYDFVGKFETLEEDANYFLQMIGAPKELKFPNFKDRHSSDERTNAQVVRQYLKDLTRTERQLIYDFYYLDYLMFNYTTP	542

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

TAF4B_pLDDT.png

CHST9_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TAF4B
CHST9

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to TAF4B-CHST9

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to TAF4B-CHST9

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source