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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TAX1BP1-RABGEF1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TAX1BP1-RABGEF1
	FusionPDB ID: 89181
	FusionGDB2.0 ID: 89181
		Hgene	Tgene
	Gene symbol	TAX1BP1	RABGEF1
	Gene ID	8887	27342
	Gene name	Tax1 binding protein 1	RAB guanine nucleotide exchange factor 1
	Synonyms	CALCOCO3\|T6BP\|TXBP151	RABEX5\|RAP1\|rabex-5
	Cytomap	7p15.2	7q11.21
	Type of gene	protein-coding	protein-coding
	Description	tax1-binding protein 1TRAF6-binding proteinTax1 (human T-cell leukemia virus type I) binding protein 1	rab5 GDP/GTP exchange factorRAB guanine nucleotide exchange factor (GEF) 1rabaptin-5-associated exchange factor for Rab5
	Modification date	20200327	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000494033, ENST00000265393, ENST00000396319, ENST00000409980, ENST00000433216, ENST00000543117,	ENST00000284957, ENST00000437078, ENST00000439720, ENST00000450873, ENST00000484547,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	17 X 11 X 11=2057	7 X 7 X 5=245
	# samples	19	7
	** MAII score	log2(19/2057*10)=-3.43647047019399 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TAX1BP1 [Title/Abstract] AND RABGEF1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TAX1BP1(27809453)-RABGEF1(66260498), # samples:2
Anticipated loss of major functional domain due to fusion event.	TAX1BP1-RABGEF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TAX1BP1-RABGEF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TAX1BP1-RABGEF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TAX1BP1-RABGEF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TAX1BP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RABGEF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	MESO	TCGA-TS-A8AY-01A	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+
ChimerDB4	MESO	TCGA-TS-A8AY	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000543117	TAX1BP1	chr7	27809453	+	ENST00000450873	RABGEF1	chr7	66260498	+	2293	797	185	1759	524
ENST00000543117	TAX1BP1	chr7	27809453	+	ENST00000284957	RABGEF1	chr7	66260498	+	3940	797	185	1759	524
ENST00000543117	TAX1BP1	chr7	27809453	+	ENST00000439720	RABGEF1	chr7	66260498	+	3143	797	185	1759	524
ENST00000543117	TAX1BP1	chr7	27809453	+	ENST00000437078	RABGEF1	chr7	66260498	+	2052	797	185	1759	524
ENST00000265393	TAX1BP1	chr7	27809453	+	ENST00000450873	RABGEF1	chr7	66260498	+	2290	794	182	1756	524
ENST00000265393	TAX1BP1	chr7	27809453	+	ENST00000284957	RABGEF1	chr7	66260498	+	3937	794	182	1756	524
ENST00000265393	TAX1BP1	chr7	27809453	+	ENST00000439720	RABGEF1	chr7	66260498	+	3140	794	182	1756	524
ENST00000265393	TAX1BP1	chr7	27809453	+	ENST00000437078	RABGEF1	chr7	66260498	+	2049	794	182	1756	524
ENST00000409980	TAX1BP1	chr7	27809453	+	ENST00000450873	RABGEF1	chr7	66260498	+	2243	747	135	1709	524
ENST00000409980	TAX1BP1	chr7	27809453	+	ENST00000284957	RABGEF1	chr7	66260498	+	3890	747	135	1709	524
ENST00000409980	TAX1BP1	chr7	27809453	+	ENST00000439720	RABGEF1	chr7	66260498	+	3093	747	135	1709	524
ENST00000409980	TAX1BP1	chr7	27809453	+	ENST00000437078	RABGEF1	chr7	66260498	+	2002	747	135	1709	524
ENST00000433216	TAX1BP1	chr7	27809453	+	ENST00000450873	RABGEF1	chr7	66260498	+	2050	554	395	1516	373
ENST00000433216	TAX1BP1	chr7	27809453	+	ENST00000284957	RABGEF1	chr7	66260498	+	3697	554	395	1516	373
ENST00000433216	TAX1BP1	chr7	27809453	+	ENST00000439720	RABGEF1	chr7	66260498	+	2900	554	395	1516	373
ENST00000433216	TAX1BP1	chr7	27809453	+	ENST00000437078	RABGEF1	chr7	66260498	+	1809	554	395	1516	373
ENST00000396319	TAX1BP1	chr7	27809453	+	ENST00000450873	RABGEF1	chr7	66260498	+	2196	700	88	1662	524
ENST00000396319	TAX1BP1	chr7	27809453	+	ENST00000284957	RABGEF1	chr7	66260498	+	3843	700	88	1662	524
ENST00000396319	TAX1BP1	chr7	27809453	+	ENST00000439720	RABGEF1	chr7	66260498	+	3046	700	88	1662	524
ENST00000396319	TAX1BP1	chr7	27809453	+	ENST00000437078	RABGEF1	chr7	66260498	+	1955	700	88	1662	524

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000543117	ENST00000450873	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000257859	0.9997421
ENST00000543117	ENST00000284957	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000193628	0.99980634
ENST00000543117	ENST00000439720	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000244578	0.99975544
ENST00000543117	ENST00000437078	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000523023	0.99947697
ENST00000265393	ENST00000450873	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000208555	0.99979144
ENST00000265393	ENST00000284957	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000192725	0.9998073
ENST00000265393	ENST00000439720	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000239195	0.9997608
ENST00000265393	ENST00000437078	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000474106	0.9995259
ENST00000409980	ENST00000450873	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000216497	0.9997836
ENST00000409980	ENST00000284957	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000194385	0.9998056
ENST00000409980	ENST00000439720	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000245026	0.99975497
ENST00000409980	ENST00000437078	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000494895	0.99950504
ENST00000433216	ENST00000450873	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000168463	0.99983156
ENST00000433216	ENST00000284957	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000133988	0.999866
ENST00000433216	ENST00000439720	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000169035	0.99983096
ENST00000433216	ENST00000437078	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.00033534	0.99966466
ENST00000396319	ENST00000450873	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000223662	0.9997763
ENST00000396319	ENST00000284957	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000193118	0.99980694
ENST00000396319	ENST00000439720	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000236956	0.9997631
ENST00000396319	ENST00000437078	TAX1BP1	chr7	27809453	+	RABGEF1	chr7	66260498	+	0.000505781	0.9994942

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>89181_89181_1_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000265393_RABGEF1_chr7_66260498_ENST00000284957_length(amino acids)=524AA_BP=204
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGY
YLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
QVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLA
IQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGN
PPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLL

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>89181_89181_2_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000265393_RABGEF1_chr7_66260498_ENST00000437078_length(amino acids)=524AA_BP=204
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGY
YLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
QVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLA
IQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGN
PPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLL

--------------------------------------------------------------

>89181_89181_3_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000265393_RABGEF1_chr7_66260498_ENST00000439720_length(amino acids)=524AA_BP=204
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGY
YLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
QVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLA
IQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGN
PPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLL

--------------------------------------------------------------

>89181_89181_4_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000265393_RABGEF1_chr7_66260498_ENST00000450873_length(amino acids)=524AA_BP=204
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGY
YLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
QVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLA
IQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGN
PPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLL

--------------------------------------------------------------

>89181_89181_5_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000396319_RABGEF1_chr7_66260498_ENST00000284957_length(amino acids)=524AA_BP=204
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGY
YLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
QVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLA
IQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGN
PPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLL

--------------------------------------------------------------

>89181_89181_6_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000396319_RABGEF1_chr7_66260498_ENST00000437078_length(amino acids)=524AA_BP=204
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGY
YLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
QVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLA
IQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGN
PPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLL

--------------------------------------------------------------

>89181_89181_7_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000396319_RABGEF1_chr7_66260498_ENST00000439720_length(amino acids)=524AA_BP=204
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGY
YLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
QVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLA
IQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGN
PPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLL

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>89181_89181_8_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000396319_RABGEF1_chr7_66260498_ENST00000450873_length(amino acids)=524AA_BP=204
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGY
YLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
QVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLA
IQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGN
PPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLL

--------------------------------------------------------------

>89181_89181_9_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000409980_RABGEF1_chr7_66260498_ENST00000284957_length(amino acids)=524AA_BP=204
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGY
YLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
QVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLA
IQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGN
PPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLL

--------------------------------------------------------------

>89181_89181_10_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000409980_RABGEF1_chr7_66260498_ENST00000437078_length(amino acids)=524AA_BP=204
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGY
YLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
QVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLA
IQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGN
PPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLL

--------------------------------------------------------------

>89181_89181_11_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000409980_RABGEF1_chr7_66260498_ENST00000439720_length(amino acids)=524AA_BP=204
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGY
YLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
QVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLA
IQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGN
PPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLL

--------------------------------------------------------------

>89181_89181_12_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000409980_RABGEF1_chr7_66260498_ENST00000450873_length(amino acids)=524AA_BP=204
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGY
YLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
QVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLA
IQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGN
PPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLL

--------------------------------------------------------------

>89181_89181_13_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000433216_RABGEF1_chr7_66260498_ENST00000284957_length(amino acids)=373AA_BP=53
MKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIM
DQIEKYIMTRLYKYVFCPETTDDEKKDLAIQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHI
FNAIKITKNEPASADDFLPTLIYIVLKGNPPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQ
TSPRKQEAESWSPDACLGVKQMYKNLDLLSQLNERQERIMNEAKKLEKDLIDWTDGIAREVQDIVEKYPLEIKPPNQPLAAIDSENVEND

--------------------------------------------------------------

>89181_89181_14_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000433216_RABGEF1_chr7_66260498_ENST00000437078_length(amino acids)=373AA_BP=53
MKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIM
DQIEKYIMTRLYKYVFCPETTDDEKKDLAIQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHI
FNAIKITKNEPASADDFLPTLIYIVLKGNPPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQ
TSPRKQEAESWSPDACLGVKQMYKNLDLLSQLNERQERIMNEAKKLEKDLIDWTDGIAREVQDIVEKYPLEIKPPNQPLAAIDSENVEND

--------------------------------------------------------------

>89181_89181_15_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000433216_RABGEF1_chr7_66260498_ENST00000439720_length(amino acids)=373AA_BP=53
MKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIM
DQIEKYIMTRLYKYVFCPETTDDEKKDLAIQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHI
FNAIKITKNEPASADDFLPTLIYIVLKGNPPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQ
TSPRKQEAESWSPDACLGVKQMYKNLDLLSQLNERQERIMNEAKKLEKDLIDWTDGIAREVQDIVEKYPLEIKPPNQPLAAIDSENVEND

--------------------------------------------------------------

>89181_89181_16_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000433216_RABGEF1_chr7_66260498_ENST00000450873_length(amino acids)=373AA_BP=53
MKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIM
DQIEKYIMTRLYKYVFCPETTDDEKKDLAIQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHI
FNAIKITKNEPASADDFLPTLIYIVLKGNPPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQ
TSPRKQEAESWSPDACLGVKQMYKNLDLLSQLNERQERIMNEAKKLEKDLIDWTDGIAREVQDIVEKYPLEIKPPNQPLAAIDSENVEND

--------------------------------------------------------------

>89181_89181_17_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000543117_RABGEF1_chr7_66260498_ENST00000284957_length(amino acids)=524AA_BP=204
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGY
YLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
QVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLA
IQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGN
PPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLL

--------------------------------------------------------------

>89181_89181_18_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000543117_RABGEF1_chr7_66260498_ENST00000437078_length(amino acids)=524AA_BP=204
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGY
YLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
QVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLA
IQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGN
PPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLL

--------------------------------------------------------------

>89181_89181_19_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000543117_RABGEF1_chr7_66260498_ENST00000439720_length(amino acids)=524AA_BP=204
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGY
YLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
QVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLA
IQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGN
PPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLL

--------------------------------------------------------------

>89181_89181_20_TAX1BP1-RABGEF1_TAX1BP1_chr7_27809453_ENST00000543117_RABGEF1_chr7_66260498_ENST00000450873_length(amino acids)=524AA_BP=204
MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGY
YLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE
QVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLA
IQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGN
PPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:27809453/chr7:66260498)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RABGEF1

chr7:27809453

chr7:66260498

ENST00000284957

232_375

171.0

492.0

Domain

VPS9

Tgene

RABGEF1

chr7:27809453

chr7:66260498

ENST00000450873

232_375

171.0

492.0

Domain

VPS9

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TAX1BP1

chr7:27809453

chr7:66260498

ENST00000265393

144_599

204.0

748.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TAX1BP1

chr7:27809453

chr7:66260498

ENST00000396319

144_599

204.0

790.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TAX1BP1

chr7:27809453

chr7:66260498

ENST00000433216

144_599

47.0

591.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TAX1BP1

chr7:27809453

chr7:66260498

ENST00000543117

144_599

204.0

748.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TAX1BP1

chr7:27809453

chr7:66260498

ENST00000265393

320_420

204.0

748.0

Region

Note=Oligomerization

Hgene

TAX1BP1

chr7:27809453

chr7:66260498

ENST00000396319

320_420

204.0

790.0

Region

Note=Oligomerization

Hgene

TAX1BP1

chr7:27809453

chr7:66260498

ENST00000433216

320_420

47.0

591.0

Region

Note=Oligomerization

Hgene

TAX1BP1

chr7:27809453

chr7:66260498

ENST00000543117

320_420

204.0

748.0

Region

Note=Oligomerization

Hgene

TAX1BP1

chr7:27809453

chr7:66260498

ENST00000265393

727_753

204.0

748.0

Zinc finger

UBZ1-type 1

Hgene

TAX1BP1

chr7:27809453

chr7:66260498

ENST00000265393

754_780

204.0

748.0

Zinc finger

UBZ1-type 2

Hgene

TAX1BP1

chr7:27809453

chr7:66260498

ENST00000396319

727_753

204.0

790.0

Zinc finger

UBZ1-type 1

Hgene

TAX1BP1

chr7:27809453

chr7:66260498

ENST00000396319

754_780

204.0

790.0

Zinc finger

UBZ1-type 2

Hgene

TAX1BP1

chr7:27809453

chr7:66260498

ENST00000433216

727_753

47.0

591.0

Zinc finger

UBZ1-type 1

Hgene

TAX1BP1

chr7:27809453

chr7:66260498

ENST00000433216

754_780

47.0

591.0

Zinc finger

UBZ1-type 2

Hgene

TAX1BP1

chr7:27809453

chr7:66260498

ENST00000543117

727_753

204.0

748.0

Zinc finger

UBZ1-type 1

Hgene

TAX1BP1

chr7:27809453

chr7:66260498

ENST00000543117

754_780

204.0

748.0

Zinc finger

UBZ1-type 2

Tgene

RABGEF1

chr7:27809453

chr7:66260498

ENST00000284957

13_47

171.0

492.0

Zinc finger

A20-type

Tgene

RABGEF1

chr7:27809453

chr7:66260498

ENST00000450873

13_47

171.0

492.0

Zinc finger

A20-type

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1126_TAX1BP1_27809453_RABGEF1_66260498_1126_TAX1BP1_27809453_RABGEF1_66260498_ranked_0.pdb	TAX1BP1	27809453	27809453	ENST00000437078	RABGEF1	chr7	66260498	+	MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGY YLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLRE QVGRMERELNHEKERCDQLQAEQKDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLA IQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGN PPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLL	524

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

TAX1BP1_pLDDT.png

RABGEF1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TAX1BP1
RABGEF1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	RABGEF1	chr7:27809453	chr7:66260498	ENST00000284957		3	9	1_74	171.0	492.0	ubiquitinated proteins
Tgene	RABGEF1	chr7:27809453	chr7:66260498	ENST00000450873		4	10	1_74	171.0	492.0	ubiquitinated proteins

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Related Drugs to TAX1BP1-RABGEF1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to TAX1BP1-RABGEF1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source