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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TBC1D10A-ANK1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TBC1D10A-ANK1
FusionPDB ID: 89190
FusionGDB2.0 ID: 89190
HgeneTgene
Gene symbol

TBC1D10A

ANK1

Gene ID

83874

286

Gene nameTBC1 domain family member 10Aankyrin 1
SynonymsEPI64|TBC1D10|dJ130H16.1|dJ130H16.2ANK|SPH1|SPH2
Cytomap

22q12.2

8p11.21

Type of geneprotein-codingprotein-coding
DescriptionTBC1 domain family member 10AEBP50-PDX interactor of 64 kDaEBP50-PDZ interactor of 64 kDrab27A-GAP-alphaankyrin-1ANK-1ankyrin 1, erythrocyticankyrin-Rerythrocyte ankyrin
Modification date2020031320200313
UniProtAcc.

P16157

Ensembl transtripts involved in fusion geneENST idsENST00000215790, ENST00000403362, 
ENST00000403477, ENST00000490449, 
ENST00000314214, ENST00000457297, 
ENST00000521407, ENST00000522231, 
ENST00000522543, ENST00000265709, 
ENST00000289734, ENST00000347528, 
ENST00000352337, ENST00000379758, 
ENST00000396942, ENST00000396945, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 6 X 5=18015 X 9 X 9=1215
# samples 818
** MAII scorelog2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1215*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TBC1D10A [Title/Abstract] AND ANK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TBC1D10A(30700520)-ANK1(41591587), # samples:3
Anticipated loss of major functional domain due to fusion event.TBC1D10A-ANK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TBC1D10A-ANK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TBC1D10A-ANK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TBC1D10A-ANK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TBC1D10A-ANK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TBC1D10A-ANK1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TBC1D10A-ANK1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTBC1D10A

GO:0045862

positive regulation of proteolysis

18387192

HgeneTBC1D10A

GO:0097202

activation of cysteine-type endopeptidase activity

18387192

TgeneANK1

GO:0006888

ER to Golgi vesicle-mediated transport

18768923


check buttonFusion gene breakpoints across TBC1D10A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-PG-A914-01ATBC1D10Achr22

30700520

-ANK1chr8

41591587

-
ChimerDB4UCECTCGA-PG-A914TBC1D10Achr22

30700520

-ANK1chr8

41591587

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000215790TBC1D10Achr2230700520-ENST00000347528ANK1chr841591587-84984744859901980
ENST00000215790TBC1D10Achr2230700520-ENST00000289734ANK1chr841591587-85584744859871979
ENST00000215790TBC1D10Achr2230700520-ENST00000379758ANK1chr841591587-83514744858491933
ENST00000215790TBC1D10Achr2230700520-ENST00000396942ANK1chr841591587-86274744860622004
ENST00000215790TBC1D10Achr2230700520-ENST00000396945ANK1chr841591587-82674744857651905
ENST00000215790TBC1D10Achr2230700520-ENST00000352337ANK1chr841591587-84864744859211957
ENST00000215790TBC1D10Achr2230700520-ENST00000265709ANK1chr841591587-63434744859391963
ENST00000403477TBC1D10Achr2230700520-ENST00000347528ANK1chr841591587-83743502058661948
ENST00000403477TBC1D10Achr2230700520-ENST00000289734ANK1chr841591587-84343502058631947
ENST00000403477TBC1D10Achr2230700520-ENST00000379758ANK1chr841591587-82273502057251901
ENST00000403477TBC1D10Achr2230700520-ENST00000396942ANK1chr841591587-85033502059381972
ENST00000403477TBC1D10Achr2230700520-ENST00000396945ANK1chr841591587-81433502056411873
ENST00000403477TBC1D10Achr2230700520-ENST00000352337ANK1chr841591587-83623502057971925
ENST00000403477TBC1D10Achr2230700520-ENST00000265709ANK1chr841591587-62193502058151931

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000215790ENST00000347528TBC1D10Achr2230700520-ANK1chr841591587-0.0030607370.9969393
ENST00000215790ENST00000289734TBC1D10Achr2230700520-ANK1chr841591587-0.0029421320.9970579
ENST00000215790ENST00000379758TBC1D10Achr2230700520-ANK1chr841591587-0.0023560350.9976439
ENST00000215790ENST00000396942TBC1D10Achr2230700520-ANK1chr841591587-0.0035119140.9964881
ENST00000215790ENST00000396945TBC1D10Achr2230700520-ANK1chr841591587-0.0033803760.9966196
ENST00000215790ENST00000352337TBC1D10Achr2230700520-ANK1chr841591587-0.0035031040.996497
ENST00000215790ENST00000265709TBC1D10Achr2230700520-ANK1chr841591587-0.0056328290.9943672
ENST00000403477ENST00000347528TBC1D10Achr2230700520-ANK1chr841591587-0.0027536620.9972464
ENST00000403477ENST00000289734TBC1D10Achr2230700520-ANK1chr841591587-0.0026459170.99735415
ENST00000403477ENST00000379758TBC1D10Achr2230700520-ANK1chr841591587-0.0021426790.9978573
ENST00000403477ENST00000396942TBC1D10Achr2230700520-ANK1chr841591587-0.0031598650.9968401
ENST00000403477ENST00000396945TBC1D10Achr2230700520-ANK1chr841591587-0.0030406150.99695945
ENST00000403477ENST00000352337TBC1D10Achr2230700520-ANK1chr841591587-0.0031510130.996849
ENST00000403477ENST00000265709TBC1D10Achr2230700520-ANK1chr841591587-0.0052895020.99471045

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>89190_89190_1_TBC1D10A-ANK1_TBC1D10A_chr22_30700520_ENST00000215790_ANK1_chr8_41591587_ENST00000265709_length(amino acids)=1963AA_BP=142
MEPRPPALRRPIGAARGRGVGGSRAAEVAAGAQAAGAAGMAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFA
ERRIDKFGFIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA
LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK
VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR
GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH
RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL
HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC
MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL
LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY
GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK
HRMSFPETVDEILDVSEDEGTAHITIMGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKE
YDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLAS
RIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYF
VIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPP
SWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFV
IFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSS
REPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELAR
ELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNG
YSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLE
GALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVT
ERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQE

--------------------------------------------------------------

>89190_89190_2_TBC1D10A-ANK1_TBC1D10A_chr22_30700520_ENST00000215790_ANK1_chr8_41591587_ENST00000289734_length(amino acids)=1979AA_BP=142
MEPRPPALRRPIGAARGRGVGGSRAAEVAAGAQAAGAAGMAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFA
ERRIDKFGFIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA
LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK
VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR
GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH
RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL
HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC
MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL
LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY
GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK
HRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIP
SSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPT
GAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQ
DYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRD
SGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDP
REGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLS
FLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVED
INRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDEL
LSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPR
GPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQ
DWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKN

--------------------------------------------------------------

>89190_89190_3_TBC1D10A-ANK1_TBC1D10A_chr22_30700520_ENST00000215790_ANK1_chr8_41591587_ENST00000347528_length(amino acids)=1980AA_BP=142
MEPRPPALRRPIGAARGRGVGGSRAAEVAAGAQAAGAAGMAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFA
ERRIDKFGFIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA
LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK
VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR
GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH
RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL
HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC
MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL
LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY
GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK
HRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIP
SSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPT
GAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQ
DYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRD
SGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDP
REGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLS
FLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVED
INRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDEL
LSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPR
GPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQ
DWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKN
TFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVDIDYFMKHSKDHTSTPNP

--------------------------------------------------------------

>89190_89190_4_TBC1D10A-ANK1_TBC1D10A_chr22_30700520_ENST00000215790_ANK1_chr8_41591587_ENST00000352337_length(amino acids)=1957AA_BP=142
MEPRPPALRRPIGAARGRGVGGSRAAEVAAGAQAAGAAGMAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFA
ERRIDKFGFIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA
LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK
VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR
GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH
RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL
HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC
MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL
LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY
GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK
HRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIP
SSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPT
GAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQ
DYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRD
SGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDP
REGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLS
FLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVED
INRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDEL
LSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPR
GPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQ
DWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKN

--------------------------------------------------------------

>89190_89190_5_TBC1D10A-ANK1_TBC1D10A_chr22_30700520_ENST00000215790_ANK1_chr8_41591587_ENST00000379758_length(amino acids)=1933AA_BP=142
MEPRPPALRRPIGAARGRGVGGSRAAEVAAGAQAAGAAGMAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFA
ERRIDKFGFIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA
LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK
VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR
GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH
RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL
HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC
MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL
LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY
GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK
HRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIP
SSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPT
GAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQ
DYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRD
SGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDP
REGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLS
FLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVED
INRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDEL
LSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPR
GPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQ
DWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKN

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>89190_89190_6_TBC1D10A-ANK1_TBC1D10A_chr22_30700520_ENST00000215790_ANK1_chr8_41591587_ENST00000396942_length(amino acids)=2004AA_BP=142
MEPRPPALRRPIGAARGRGVGGSRAAEVAAGAQAAGAAGMAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFA
ERRIDKFGFIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA
LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK
VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR
GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH
RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL
HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC
MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL
LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY
GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK
HRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIP
SSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPT
GAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQ
DYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRD
SGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDP
REGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLS
FLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVED
INRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDEL
LSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPR
GPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQ
DWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKN
TFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIVTKKIIRKVVRQIDLSSADAAQEHEEVTVEGPLEDPSELEVDIDYFMKHSKVELRGSGL

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>89190_89190_7_TBC1D10A-ANK1_TBC1D10A_chr22_30700520_ENST00000215790_ANK1_chr8_41591587_ENST00000396945_length(amino acids)=1905AA_BP=142
MEPRPPALRRPIGAARGRGVGGSRAAEVAAGAQAAGAAGMAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFA
ERRIDKFGFIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTA
LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK
VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR
GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH
RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL
HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC
MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL
LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY
GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDK
HRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIP
SSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPT
GAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQ
DYDTIGPEGGSLKSKLVPLVQATFPENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRD
SGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDP
REGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLS
FLRKAMKYEDTQHILCHLNITMPPCAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVED
INRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDEL
LSPASLGCALSSPLRADQYWNEVAVLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPR
GPELGSLELVEDDTVDSDATNGLIDLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQ
DWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKN

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>89190_89190_8_TBC1D10A-ANK1_TBC1D10A_chr22_30700520_ENST00000403477_ANK1_chr8_41591587_ENST00000265709_length(amino acids)=1931AA_BP=110
MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGAPCPLLHRLEEVPLEVLRQRE
SKWLDMLNNWDKWMAKKHKKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT
PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS
KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD
HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH
VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP
LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN
AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL
LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ
QGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELI
SFKAERRDSRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLV
SFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRE
LVVLRSENGSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATF
PENAVTKRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQW
EDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHEN
FVEVARSRDIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPP
CAKGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWV
IREGQNANMENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVA
VLDAIPLAATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLI
DLLEQEEGQRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEV
TQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQF

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>89190_89190_9_TBC1D10A-ANK1_TBC1D10A_chr22_30700520_ENST00000403477_ANK1_chr8_41591587_ENST00000289734_length(amino acids)=1947AA_BP=110
MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGAPCPLLHRLEEVPLEVLRQRE
SKWLDMLNNWDKWMAKKHKKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT
PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS
KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD
HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH
VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP
LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN
AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL
LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ
QGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRD
SRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARG
GSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSEN
GSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKR
VKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTK
LVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSR
DIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAE
DRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNAN
MENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLA
ATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEG
QRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQ
GTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIV

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>89190_89190_10_TBC1D10A-ANK1_TBC1D10A_chr22_30700520_ENST00000403477_ANK1_chr8_41591587_ENST00000347528_length(amino acids)=1948AA_BP=110
MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGAPCPLLHRLEEVPLEVLRQRE
SKWLDMLNNWDKWMAKKHKKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT
PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS
KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD
HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH
VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP
LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN
AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL
LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ
QGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRD
SRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARG
GSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSEN
GSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKR
VKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTK
LVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSR
DIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAE
DRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNAN
MENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLA
ATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEG
QRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQ
GTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIV

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>89190_89190_11_TBC1D10A-ANK1_TBC1D10A_chr22_30700520_ENST00000403477_ANK1_chr8_41591587_ENST00000352337_length(amino acids)=1925AA_BP=110
MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGAPCPLLHRLEEVPLEVLRQRE
SKWLDMLNNWDKWMAKKHKKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT
PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS
KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD
HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH
VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP
LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN
AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL
LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ
QGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRD
SRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARG
GSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSEN
GSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKR
VKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTK
LVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSR
DIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAE
DRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNAN
MENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLA
ATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEG
QRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQ
GTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIV

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>89190_89190_12_TBC1D10A-ANK1_TBC1D10A_chr22_30700520_ENST00000403477_ANK1_chr8_41591587_ENST00000379758_length(amino acids)=1901AA_BP=110
MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGAPCPLLHRLEEVPLEVLRQRE
SKWLDMLNNWDKWMAKKHKKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT
PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS
KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD
HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH
VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP
LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN
AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL
LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ
QGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRD
SRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARG
GSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSEN
GSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKR
VKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTK
LVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSR
DIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAE
DRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNAN
MENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLA
ATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEG
QRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQ
GTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIV

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>89190_89190_13_TBC1D10A-ANK1_TBC1D10A_chr22_30700520_ENST00000403477_ANK1_chr8_41591587_ENST00000396942_length(amino acids)=1972AA_BP=110
MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGAPCPLLHRLEEVPLEVLRQRE
SKWLDMLNNWDKWMAKKHKKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT
PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS
KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD
HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH
VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP
LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN
AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL
LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ
QGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRD
SRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARG
GSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSEN
GSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKR
VKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTK
LVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSR
DIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAE
DRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNAN
MENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLA
ATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEG
QRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQ
GTSTMTEGLEPGGSQEYEKVLVSVSEHTWTEQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQFTDEQGNIV

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>89190_89190_14_TBC1D10A-ANK1_TBC1D10A_chr22_30700520_ENST00000403477_ANK1_chr8_41591587_ENST00000396945_length(amino acids)=1873AA_BP=110
MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGAPCPLLHRLEEVPLEVLRQRE
SKWLDMLNNWDKWMAKKHKKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFT
PLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS
KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD
HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH
VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP
LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN
AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL
LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQ
QGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRD
SRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARG
GSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSEN
GSVWKEHRSRYGESYLDQILNGMDEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVTKR
VKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTK
LVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSR
DIEVLEGMSLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLRKAMKYEDTQHILCHLNITMPPCAKGSGAE
DRRRTPTPLALRYSILSESTPGSLSGTEQAEMKMAVISEHLGLSWAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNAN
MENLYTALQSIDRGEIVNMLEGSGRQSRNLKPDRRHTDRDYSLSPSQMNGYSSLQDELLSPASLGCALSSPLRADQYWNEVAVLDAIPLA
ATEHDTMLEMSDMQVWSAGLTPSLVTAEDSSLECSKAEDSDATGHEWKLEGALSEEPRGPELGSLELVEDDTVDSDATNGLIDLLEQEEG
QRSEEKLPGSKRQDDATGAGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQ

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:30700520/chr8:41591587)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ANK1

P16157

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. {ECO:0000269|PubMed:12456646}.; FUNCTION: [Isoform Mu17]: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:12527750}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneANK1chr22:30700520chr8:41591587ENST000002657091431070_121676.01898.0DomainZU5 2
TgeneANK1chr22:30700520chr8:41591587ENST000002657091431403_148776.01898.0DomainDeath
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143913_106876.01898.0DomainZU5 1
TgeneANK1chr22:30700520chr8:41591587ENST000002897341431070_121643.02699.6666666666665DomainZU5 2
TgeneANK1chr22:30700520chr8:41591587ENST000002897341431403_148743.02699.6666666666665DomainDeath
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143913_106843.02699.6666666666665DomainZU5 1
TgeneANK1chr22:30700520chr8:41591587ENST00000314214051070_12160159.66666666666666DomainZU5 2
TgeneANK1chr22:30700520chr8:41591587ENST00000314214051403_14870159.66666666666666DomainDeath
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405913_10680159.66666666666666DomainZU5 1
TgeneANK1chr22:30700520chr8:41591587ENST000003475281421070_121643.01882.0DomainZU5 2
TgeneANK1chr22:30700520chr8:41591587ENST000003475281421403_148743.01882.0DomainDeath
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142913_106843.01882.0DomainZU5 1
TgeneANK1chr22:30700520chr8:41591587ENST000003523371421070_121643.02675.6666666666665DomainZU5 2
TgeneANK1chr22:30700520chr8:41591587ENST000003523371421403_148743.02675.6666666666665DomainDeath
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142913_106843.02675.6666666666665DomainZU5 1
TgeneANK1chr22:30700520chr8:41591587ENST000003797581411070_121643.01835.0DomainZU5 2
TgeneANK1chr22:30700520chr8:41591587ENST000003797581411403_148743.01835.0DomainDeath
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141913_106843.01835.0DomainZU5 1
TgeneANK1chr22:30700520chr8:41591587ENST000003969421431070_121643.02722.6666666666665DomainZU5 2
TgeneANK1chr22:30700520chr8:41591587ENST000003969421431403_148743.02722.6666666666665DomainDeath
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143913_106843.02722.6666666666665DomainZU5 1
TgeneANK1chr22:30700520chr8:41591587ENST000003969451401070_121643.01807.0DomainZU5 2
TgeneANK1chr22:30700520chr8:41591587ENST000003969451401403_148743.01807.0DomainDeath
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140913_106843.01807.0DomainZU5 1
TgeneANK1chr22:30700520chr8:41591587ENST00000457297031070_12160110.0DomainZU5 2
TgeneANK1chr22:30700520chr8:41591587ENST00000457297031403_14870110.0DomainDeath
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703913_10680110.0DomainZU5 1
TgeneANK1chr22:30700520chr8:41591587ENST00000522543041070_12160157.0DomainZU5 2
TgeneANK1chr22:30700520chr8:41591587ENST00000522543041403_14870157.0DomainDeath
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304913_10680157.0DomainZU5 1
TgeneANK1chr22:30700520chr8:41591587ENST000002657091431234_136276.01898.0RegionUPA domain
TgeneANK1chr22:30700520chr8:41591587ENST000002657091431383_188176.01898.0RegionNote=55 kDa regulatory domain
TgeneANK1chr22:30700520chr8:41591587ENST000002897341431234_136243.02699.6666666666665RegionUPA domain
TgeneANK1chr22:30700520chr8:41591587ENST000002897341431383_188143.02699.6666666666665RegionNote=55 kDa regulatory domain
TgeneANK1chr22:30700520chr8:41591587ENST00000314214051234_13620159.66666666666666RegionUPA domain
TgeneANK1chr22:30700520chr8:41591587ENST00000314214051383_18810159.66666666666666RegionNote=55 kDa regulatory domain
TgeneANK1chr22:30700520chr8:41591587ENST00000314214051_8270159.66666666666666RegionNote=89 kDa domain
TgeneANK1chr22:30700520chr8:41591587ENST000003475281421234_136243.01882.0RegionUPA domain
TgeneANK1chr22:30700520chr8:41591587ENST000003475281421383_188143.01882.0RegionNote=55 kDa regulatory domain
TgeneANK1chr22:30700520chr8:41591587ENST000003523371421234_136243.02675.6666666666665RegionUPA domain
TgeneANK1chr22:30700520chr8:41591587ENST000003523371421383_188143.02675.6666666666665RegionNote=55 kDa regulatory domain
TgeneANK1chr22:30700520chr8:41591587ENST000003797581411234_136243.01835.0RegionUPA domain
TgeneANK1chr22:30700520chr8:41591587ENST000003797581411383_188143.01835.0RegionNote=55 kDa regulatory domain
TgeneANK1chr22:30700520chr8:41591587ENST000003969421431234_136243.02722.6666666666665RegionUPA domain
TgeneANK1chr22:30700520chr8:41591587ENST000003969421431383_188143.02722.6666666666665RegionNote=55 kDa regulatory domain
TgeneANK1chr22:30700520chr8:41591587ENST000003969451401234_136243.01807.0RegionUPA domain
TgeneANK1chr22:30700520chr8:41591587ENST000003969451401383_188143.01807.0RegionNote=55 kDa regulatory domain
TgeneANK1chr22:30700520chr8:41591587ENST00000457297031234_13620110.0RegionUPA domain
TgeneANK1chr22:30700520chr8:41591587ENST00000457297031383_18810110.0RegionNote=55 kDa regulatory domain
TgeneANK1chr22:30700520chr8:41591587ENST00000457297031_8270110.0RegionNote=89 kDa domain
TgeneANK1chr22:30700520chr8:41591587ENST00000522543041234_13620157.0RegionUPA domain
TgeneANK1chr22:30700520chr8:41591587ENST00000522543041383_18810157.0RegionNote=55 kDa regulatory domain
TgeneANK1chr22:30700520chr8:41591587ENST00000522543041_8270157.0RegionNote=89 kDa domain
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143110_13976.01898.0RepeatNote=ANK 3
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143143_17276.01898.0RepeatNote=ANK 4
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143174_20176.01898.0RepeatNote=ANK 5
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143205_23476.01898.0RepeatNote=ANK 6
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143238_26776.01898.0RepeatNote=ANK 7
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143271_30076.01898.0RepeatNote=ANK 8
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143304_33376.01898.0RepeatNote=ANK 9
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143337_36676.01898.0RepeatNote=ANK 10
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143370_39976.01898.0RepeatNote=ANK 11
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143403_43276.01898.0RepeatNote=ANK 12
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143436_46576.01898.0RepeatNote=ANK 13
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143469_49876.01898.0RepeatNote=ANK 14
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143502_53176.01898.0RepeatNote=ANK 15
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143535_56476.01898.0RepeatNote=ANK 16
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143568_59776.01898.0RepeatNote=ANK 17
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143601_63076.01898.0RepeatNote=ANK 18
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143634_66376.01898.0RepeatNote=ANK 19
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143667_69676.01898.0RepeatNote=ANK 20
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143700_72976.01898.0RepeatNote=ANK 21
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143733_76276.01898.0RepeatNote=ANK 22
TgeneANK1chr22:30700520chr8:41591587ENST00000265709143766_79576.01898.0RepeatNote=ANK 23
TgeneANK1chr22:30700520chr8:41591587ENST0000026570914377_10676.01898.0RepeatNote=ANK 2
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143110_13943.02699.6666666666665RepeatNote=ANK 3
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143143_17243.02699.6666666666665RepeatNote=ANK 4
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143174_20143.02699.6666666666665RepeatNote=ANK 5
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143205_23443.02699.6666666666665RepeatNote=ANK 6
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143238_26743.02699.6666666666665RepeatNote=ANK 7
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143271_30043.02699.6666666666665RepeatNote=ANK 8
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143304_33343.02699.6666666666665RepeatNote=ANK 9
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143337_36643.02699.6666666666665RepeatNote=ANK 10
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143370_39943.02699.6666666666665RepeatNote=ANK 11
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143403_43243.02699.6666666666665RepeatNote=ANK 12
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143436_46543.02699.6666666666665RepeatNote=ANK 13
TgeneANK1chr22:30700520chr8:41591587ENST0000028973414344_7343.02699.6666666666665RepeatNote=ANK 1
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143469_49843.02699.6666666666665RepeatNote=ANK 14
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143502_53143.02699.6666666666665RepeatNote=ANK 15
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143535_56443.02699.6666666666665RepeatNote=ANK 16
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143568_59743.02699.6666666666665RepeatNote=ANK 17
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143601_63043.02699.6666666666665RepeatNote=ANK 18
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143634_66343.02699.6666666666665RepeatNote=ANK 19
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143667_69643.02699.6666666666665RepeatNote=ANK 20
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143700_72943.02699.6666666666665RepeatNote=ANK 21
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143733_76243.02699.6666666666665RepeatNote=ANK 22
TgeneANK1chr22:30700520chr8:41591587ENST00000289734143766_79543.02699.6666666666665RepeatNote=ANK 23
TgeneANK1chr22:30700520chr8:41591587ENST0000028973414377_10643.02699.6666666666665RepeatNote=ANK 2
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405110_1390159.66666666666666RepeatNote=ANK 3
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405143_1720159.66666666666666RepeatNote=ANK 4
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405174_2010159.66666666666666RepeatNote=ANK 5
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405205_2340159.66666666666666RepeatNote=ANK 6
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405238_2670159.66666666666666RepeatNote=ANK 7
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405271_3000159.66666666666666RepeatNote=ANK 8
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405304_3330159.66666666666666RepeatNote=ANK 9
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405337_3660159.66666666666666RepeatNote=ANK 10
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405370_3990159.66666666666666RepeatNote=ANK 11
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405403_4320159.66666666666666RepeatNote=ANK 12
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405436_4650159.66666666666666RepeatNote=ANK 13
TgeneANK1chr22:30700520chr8:41591587ENST000003142140544_730159.66666666666666RepeatNote=ANK 1
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405469_4980159.66666666666666RepeatNote=ANK 14
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405502_5310159.66666666666666RepeatNote=ANK 15
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405535_5640159.66666666666666RepeatNote=ANK 16
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405568_5970159.66666666666666RepeatNote=ANK 17
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405601_6300159.66666666666666RepeatNote=ANK 18
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405634_6630159.66666666666666RepeatNote=ANK 19
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405667_6960159.66666666666666RepeatNote=ANK 20
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405700_7290159.66666666666666RepeatNote=ANK 21
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405733_7620159.66666666666666RepeatNote=ANK 22
TgeneANK1chr22:30700520chr8:41591587ENST0000031421405766_7950159.66666666666666RepeatNote=ANK 23
TgeneANK1chr22:30700520chr8:41591587ENST000003142140577_1060159.66666666666666RepeatNote=ANK 2
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142110_13943.01882.0RepeatNote=ANK 3
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142143_17243.01882.0RepeatNote=ANK 4
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142174_20143.01882.0RepeatNote=ANK 5
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142205_23443.01882.0RepeatNote=ANK 6
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142238_26743.01882.0RepeatNote=ANK 7
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142271_30043.01882.0RepeatNote=ANK 8
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142304_33343.01882.0RepeatNote=ANK 9
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142337_36643.01882.0RepeatNote=ANK 10
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142370_39943.01882.0RepeatNote=ANK 11
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142403_43243.01882.0RepeatNote=ANK 12
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142436_46543.01882.0RepeatNote=ANK 13
TgeneANK1chr22:30700520chr8:41591587ENST0000034752814244_7343.01882.0RepeatNote=ANK 1
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142469_49843.01882.0RepeatNote=ANK 14
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142502_53143.01882.0RepeatNote=ANK 15
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142535_56443.01882.0RepeatNote=ANK 16
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142568_59743.01882.0RepeatNote=ANK 17
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142601_63043.01882.0RepeatNote=ANK 18
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142634_66343.01882.0RepeatNote=ANK 19
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142667_69643.01882.0RepeatNote=ANK 20
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142700_72943.01882.0RepeatNote=ANK 21
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142733_76243.01882.0RepeatNote=ANK 22
TgeneANK1chr22:30700520chr8:41591587ENST00000347528142766_79543.01882.0RepeatNote=ANK 23
TgeneANK1chr22:30700520chr8:41591587ENST0000034752814277_10643.01882.0RepeatNote=ANK 2
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142110_13943.02675.6666666666665RepeatNote=ANK 3
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142143_17243.02675.6666666666665RepeatNote=ANK 4
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142174_20143.02675.6666666666665RepeatNote=ANK 5
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142205_23443.02675.6666666666665RepeatNote=ANK 6
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142238_26743.02675.6666666666665RepeatNote=ANK 7
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142271_30043.02675.6666666666665RepeatNote=ANK 8
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142304_33343.02675.6666666666665RepeatNote=ANK 9
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142337_36643.02675.6666666666665RepeatNote=ANK 10
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142370_39943.02675.6666666666665RepeatNote=ANK 11
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142403_43243.02675.6666666666665RepeatNote=ANK 12
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142436_46543.02675.6666666666665RepeatNote=ANK 13
TgeneANK1chr22:30700520chr8:41591587ENST0000035233714244_7343.02675.6666666666665RepeatNote=ANK 1
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142469_49843.02675.6666666666665RepeatNote=ANK 14
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142502_53143.02675.6666666666665RepeatNote=ANK 15
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142535_56443.02675.6666666666665RepeatNote=ANK 16
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142568_59743.02675.6666666666665RepeatNote=ANK 17
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142601_63043.02675.6666666666665RepeatNote=ANK 18
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142634_66343.02675.6666666666665RepeatNote=ANK 19
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142667_69643.02675.6666666666665RepeatNote=ANK 20
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142700_72943.02675.6666666666665RepeatNote=ANK 21
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142733_76243.02675.6666666666665RepeatNote=ANK 22
TgeneANK1chr22:30700520chr8:41591587ENST00000352337142766_79543.02675.6666666666665RepeatNote=ANK 23
TgeneANK1chr22:30700520chr8:41591587ENST0000035233714277_10643.02675.6666666666665RepeatNote=ANK 2
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141110_13943.01835.0RepeatNote=ANK 3
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141143_17243.01835.0RepeatNote=ANK 4
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141174_20143.01835.0RepeatNote=ANK 5
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141205_23443.01835.0RepeatNote=ANK 6
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141238_26743.01835.0RepeatNote=ANK 7
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141271_30043.01835.0RepeatNote=ANK 8
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141304_33343.01835.0RepeatNote=ANK 9
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141337_36643.01835.0RepeatNote=ANK 10
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141370_39943.01835.0RepeatNote=ANK 11
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141403_43243.01835.0RepeatNote=ANK 12
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141436_46543.01835.0RepeatNote=ANK 13
TgeneANK1chr22:30700520chr8:41591587ENST0000037975814144_7343.01835.0RepeatNote=ANK 1
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141469_49843.01835.0RepeatNote=ANK 14
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141502_53143.01835.0RepeatNote=ANK 15
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141535_56443.01835.0RepeatNote=ANK 16
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141568_59743.01835.0RepeatNote=ANK 17
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141601_63043.01835.0RepeatNote=ANK 18
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141634_66343.01835.0RepeatNote=ANK 19
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141667_69643.01835.0RepeatNote=ANK 20
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141700_72943.01835.0RepeatNote=ANK 21
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141733_76243.01835.0RepeatNote=ANK 22
TgeneANK1chr22:30700520chr8:41591587ENST00000379758141766_79543.01835.0RepeatNote=ANK 23
TgeneANK1chr22:30700520chr8:41591587ENST0000037975814177_10643.01835.0RepeatNote=ANK 2
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143110_13943.02722.6666666666665RepeatNote=ANK 3
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143143_17243.02722.6666666666665RepeatNote=ANK 4
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143174_20143.02722.6666666666665RepeatNote=ANK 5
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143205_23443.02722.6666666666665RepeatNote=ANK 6
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143238_26743.02722.6666666666665RepeatNote=ANK 7
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143271_30043.02722.6666666666665RepeatNote=ANK 8
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143304_33343.02722.6666666666665RepeatNote=ANK 9
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143337_36643.02722.6666666666665RepeatNote=ANK 10
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143370_39943.02722.6666666666665RepeatNote=ANK 11
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143403_43243.02722.6666666666665RepeatNote=ANK 12
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143436_46543.02722.6666666666665RepeatNote=ANK 13
TgeneANK1chr22:30700520chr8:41591587ENST0000039694214344_7343.02722.6666666666665RepeatNote=ANK 1
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143469_49843.02722.6666666666665RepeatNote=ANK 14
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143502_53143.02722.6666666666665RepeatNote=ANK 15
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143535_56443.02722.6666666666665RepeatNote=ANK 16
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143568_59743.02722.6666666666665RepeatNote=ANK 17
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143601_63043.02722.6666666666665RepeatNote=ANK 18
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143634_66343.02722.6666666666665RepeatNote=ANK 19
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143667_69643.02722.6666666666665RepeatNote=ANK 20
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143700_72943.02722.6666666666665RepeatNote=ANK 21
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143733_76243.02722.6666666666665RepeatNote=ANK 22
TgeneANK1chr22:30700520chr8:41591587ENST00000396942143766_79543.02722.6666666666665RepeatNote=ANK 23
TgeneANK1chr22:30700520chr8:41591587ENST0000039694214377_10643.02722.6666666666665RepeatNote=ANK 2
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140110_13943.01807.0RepeatNote=ANK 3
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140143_17243.01807.0RepeatNote=ANK 4
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140174_20143.01807.0RepeatNote=ANK 5
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140205_23443.01807.0RepeatNote=ANK 6
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140238_26743.01807.0RepeatNote=ANK 7
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140271_30043.01807.0RepeatNote=ANK 8
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140304_33343.01807.0RepeatNote=ANK 9
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140337_36643.01807.0RepeatNote=ANK 10
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140370_39943.01807.0RepeatNote=ANK 11
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140403_43243.01807.0RepeatNote=ANK 12
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140436_46543.01807.0RepeatNote=ANK 13
TgeneANK1chr22:30700520chr8:41591587ENST0000039694514044_7343.01807.0RepeatNote=ANK 1
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140469_49843.01807.0RepeatNote=ANK 14
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140502_53143.01807.0RepeatNote=ANK 15
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140535_56443.01807.0RepeatNote=ANK 16
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140568_59743.01807.0RepeatNote=ANK 17
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140601_63043.01807.0RepeatNote=ANK 18
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140634_66343.01807.0RepeatNote=ANK 19
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140667_69643.01807.0RepeatNote=ANK 20
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140700_72943.01807.0RepeatNote=ANK 21
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140733_76243.01807.0RepeatNote=ANK 22
TgeneANK1chr22:30700520chr8:41591587ENST00000396945140766_79543.01807.0RepeatNote=ANK 23
TgeneANK1chr22:30700520chr8:41591587ENST0000039694514077_10643.01807.0RepeatNote=ANK 2
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703110_1390110.0RepeatNote=ANK 3
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703143_1720110.0RepeatNote=ANK 4
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703174_2010110.0RepeatNote=ANK 5
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703205_2340110.0RepeatNote=ANK 6
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703238_2670110.0RepeatNote=ANK 7
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703271_3000110.0RepeatNote=ANK 8
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703304_3330110.0RepeatNote=ANK 9
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703337_3660110.0RepeatNote=ANK 10
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703370_3990110.0RepeatNote=ANK 11
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703403_4320110.0RepeatNote=ANK 12
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703436_4650110.0RepeatNote=ANK 13
TgeneANK1chr22:30700520chr8:41591587ENST000004572970344_730110.0RepeatNote=ANK 1
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703469_4980110.0RepeatNote=ANK 14
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703502_5310110.0RepeatNote=ANK 15
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703535_5640110.0RepeatNote=ANK 16
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703568_5970110.0RepeatNote=ANK 17
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703601_6300110.0RepeatNote=ANK 18
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703634_6630110.0RepeatNote=ANK 19
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703667_6960110.0RepeatNote=ANK 20
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703700_7290110.0RepeatNote=ANK 21
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703733_7620110.0RepeatNote=ANK 22
TgeneANK1chr22:30700520chr8:41591587ENST0000045729703766_7950110.0RepeatNote=ANK 23
TgeneANK1chr22:30700520chr8:41591587ENST000004572970377_1060110.0RepeatNote=ANK 2
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304110_1390157.0RepeatNote=ANK 3
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304143_1720157.0RepeatNote=ANK 4
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304174_2010157.0RepeatNote=ANK 5
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304205_2340157.0RepeatNote=ANK 6
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304238_2670157.0RepeatNote=ANK 7
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304271_3000157.0RepeatNote=ANK 8
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304304_3330157.0RepeatNote=ANK 9
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304337_3660157.0RepeatNote=ANK 10
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304370_3990157.0RepeatNote=ANK 11
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304403_4320157.0RepeatNote=ANK 12
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304436_4650157.0RepeatNote=ANK 13
TgeneANK1chr22:30700520chr8:41591587ENST000005225430444_730157.0RepeatNote=ANK 1
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304469_4980157.0RepeatNote=ANK 14
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304502_5310157.0RepeatNote=ANK 15
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304535_5640157.0RepeatNote=ANK 16
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304568_5970157.0RepeatNote=ANK 17
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304601_6300157.0RepeatNote=ANK 18
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304634_6630157.0RepeatNote=ANK 19
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304667_6960157.0RepeatNote=ANK 20
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304700_7290157.0RepeatNote=ANK 21
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304733_7620157.0RepeatNote=ANK 22
TgeneANK1chr22:30700520chr8:41591587ENST0000052254304766_7950157.0RepeatNote=ANK 23
TgeneANK1chr22:30700520chr8:41591587ENST000005225430477_1060157.0RepeatNote=ANK 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBC1D10Achr22:30700520chr8:41591587ENST00000215790-29111_299103.0509.0DomainRab-GAP TBC
HgeneTBC1D10Achr22:30700520chr8:41591587ENST00000403477-29111_299110.0516.0DomainRab-GAP TBC
HgeneTBC1D10Achr22:30700520chr8:41591587ENST00000215790-29505_508103.0509.0RegionNote=Binding to the PDZ domain of EBP50
HgeneTBC1D10Achr22:30700520chr8:41591587ENST00000403477-29505_508110.0516.0RegionNote=Binding to the PDZ domain of EBP50
TgeneANK1chr22:30700520chr8:41591587ENST000002657091431_82776.01898.0RegionNote=89 kDa domain
TgeneANK1chr22:30700520chr8:41591587ENST000002897341431_82743.02699.6666666666665RegionNote=89 kDa domain
TgeneANK1chr22:30700520chr8:41591587ENST000003475281421_82743.01882.0RegionNote=89 kDa domain
TgeneANK1chr22:30700520chr8:41591587ENST000003523371421_82743.02675.6666666666665RegionNote=89 kDa domain
TgeneANK1chr22:30700520chr8:41591587ENST000003797581411_82743.01835.0RegionNote=89 kDa domain
TgeneANK1chr22:30700520chr8:41591587ENST000003969421431_82743.02722.6666666666665RegionNote=89 kDa domain
TgeneANK1chr22:30700520chr8:41591587ENST000003969451401_82743.01807.0RegionNote=89 kDa domain
TgeneANK1chr22:30700520chr8:41591587ENST0000026570914344_7376.01898.0RepeatNote=ANK 1


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TBC1D10A_pLDDT.png
all structure
all structure
ANK1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TBC1D10A
ANK1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TBC1D10A-ANK1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TBC1D10A-ANK1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource