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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TBC1D14-HTRA3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TBC1D14-HTRA3
FusionPDB ID: 89209
FusionGDB2.0 ID: 89209
HgeneTgene
Gene symbol

TBC1D14

HTRA3

Gene ID

57533

94031

Gene nameTBC1 domain family member 14HtrA serine peptidase 3
Synonyms-Prsp|Tasp
Cytomap

4p16.1

4p16.1

Type of geneprotein-codingprotein-coding
DescriptionTBC1 domain family member 14serine protease HTRA3high-temperature requirement factor A3pregnancy-related serine proteaseprobable serine protease HTRA3
Modification date2020031320200313
UniProtAcc.

P83110

Ensembl transtripts involved in fusion geneENST idsENST00000409757, ENST00000448507, 
ENST00000410031, ENST00000451522, 
ENST00000446947, 		ENST00000307358, 
ENST00000382512, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 5 X 9=3602 X 3 X 3=18
# samples 134
** MAII scorelog2(13/360*10)=-1.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TBC1D14 [Title/Abstract] AND HTRA3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TBC1D14(6996029)-HTRA3(8288288), # samples:3
Anticipated loss of major functional domain due to fusion event.TBC1D14-HTRA3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TBC1D14-HTRA3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TBC1D14-HTRA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TBC1D14-HTRA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TBC1D14-HTRA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TBC1D14-HTRA3 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHTRA3

GO:0006508

proteolysis

18387192|22229724


check buttonFusion gene breakpoints across TBC1D14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HTRA3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-DK-A3IS-01ATBC1D14chr4

6925838

-HTRA3chr4

8284164

+
ChimerDB4BLCATCGA-DK-A3IS-01ATBC1D14chr4

6925838

+HTRA3chr4

8288288

+
ChimerDB4GBMTCGA-28-5204-01ATBC1D14chr4

6996029

-HTRA3chr4

8288288

+
ChimerDB4GBMTCGA-28-5204-01ATBC1D14chr4

6996029

+HTRA3chr4

8288288

+
ChimerDB4GBMTCGA-28-5204TBC1D14chr4

6996029

+HTRA3chr4

8288287

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000448507TBC1D14chr46925838+ENST00000307358HTRA3chr48288288+2653801791677532
ENST00000448507TBC1D14chr46925838+ENST00000382512HTRA3chr48288288+2147801791389436
ENST00000409757TBC1D14chr46925838+ENST00000307358HTRA3chr48288288+2698846581722554
ENST00000409757TBC1D14chr46925838+ENST00000382512HTRA3chr48288288+2192846581434458
ENST00000448507TBC1D14chr46996029+ENST00000307358HTRA3chr48288288+28931041791917612
ENST00000448507TBC1D14chr46996029+ENST00000382512HTRA3chr48288288+23871041791629516
ENST00000409757TBC1D14chr46996029+ENST00000307358HTRA3chr48288288+29381086581962634
ENST00000409757TBC1D14chr46996029+ENST00000382512HTRA3chr48288288+24321086581674538
ENST00000410031TBC1D14chr46996029+ENST00000307358HTRA3chr48288288+2211359421235397
ENST00000410031TBC1D14chr46996029+ENST00000382512HTRA3chr48288288+170535942947301
ENST00000451522TBC1D14chr46996029+ENST00000307358HTRA3chr48288288+2159307171183388
ENST00000451522TBC1D14chr46996029+ENST00000382512HTRA3chr48288288+165330717895292
ENST00000448507TBC1D14chr46996029+ENST00000307358HTRA3chr48288287+28931041791917612
ENST00000448507TBC1D14chr46996029+ENST00000382512HTRA3chr48288287+23871041791629516
ENST00000409757TBC1D14chr46996029+ENST00000307358HTRA3chr48288287+29381086581962634
ENST00000409757TBC1D14chr46996029+ENST00000382512HTRA3chr48288287+24321086581674538
ENST00000410031TBC1D14chr46996029+ENST00000307358HTRA3chr48288287+2211359421235397
ENST00000410031TBC1D14chr46996029+ENST00000382512HTRA3chr48288287+170535942947301
ENST00000451522TBC1D14chr46996029+ENST00000307358HTRA3chr48288287+2159307171183388
ENST00000451522TBC1D14chr46996029+ENST00000382512HTRA3chr48288287+165330717895292

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000448507ENST00000307358TBC1D14chr46925838+HTRA3chr48288288+0.0099788450.99002117
ENST00000448507ENST00000382512TBC1D14chr46925838+HTRA3chr48288288+0.0079471050.9920529
ENST00000409757ENST00000307358TBC1D14chr46925838+HTRA3chr48288288+0.0091849420.99081504
ENST00000409757ENST00000382512TBC1D14chr46925838+HTRA3chr48288288+0.0076212140.99237883
ENST00000448507ENST00000307358TBC1D14chr46996029+HTRA3chr48288288+0.0089897690.9910102
ENST00000448507ENST00000382512TBC1D14chr46996029+HTRA3chr48288288+0.0065563680.9934436
ENST00000409757ENST00000307358TBC1D14chr46996029+HTRA3chr48288288+0.0085277120.9914723
ENST00000409757ENST00000382512TBC1D14chr46996029+HTRA3chr48288288+0.0062213340.99377865
ENST00000410031ENST00000307358TBC1D14chr46996029+HTRA3chr48288288+0.0017584750.99824154
ENST00000410031ENST00000382512TBC1D14chr46996029+HTRA3chr48288288+0.002029350.99797064
ENST00000451522ENST00000307358TBC1D14chr46996029+HTRA3chr48288288+0.0035215460.9964785
ENST00000451522ENST00000382512TBC1D14chr46996029+HTRA3chr48288288+0.0044225820.99557745
ENST00000448507ENST00000307358TBC1D14chr46996029+HTRA3chr48288287+0.0089897690.9910102
ENST00000448507ENST00000382512TBC1D14chr46996029+HTRA3chr48288287+0.0065563680.9934436
ENST00000409757ENST00000307358TBC1D14chr46996029+HTRA3chr48288287+0.0085277120.9914723
ENST00000409757ENST00000382512TBC1D14chr46996029+HTRA3chr48288287+0.0062213340.99377865
ENST00000410031ENST00000307358TBC1D14chr46996029+HTRA3chr48288287+0.0017584750.99824154
ENST00000410031ENST00000382512TBC1D14chr46996029+HTRA3chr48288287+0.002029350.99797064
ENST00000451522ENST00000307358TBC1D14chr46996029+HTRA3chr48288287+0.0035215460.9964785
ENST00000451522ENST00000382512TBC1D14chr46996029+HTRA3chr48288287+0.0044225820.99557745

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>89209_89209_1_TBC1D14-HTRA3_TBC1D14_chr4_6925838_ENST00000409757_HTRA3_chr4_8288288_ENST00000307358_length(amino acids)=554AA_BP=262
MRAHGSRGWRRSRANSVSPWTKMTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHSLQSVDSGI
PTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTEREQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCS
VSSLGTELSTTLSVSNEDILDLVVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFARHPLFGRN
VPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAI
GSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQI
KDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRG

--------------------------------------------------------------

>89209_89209_2_TBC1D14-HTRA3_TBC1D14_chr4_6925838_ENST00000409757_HTRA3_chr4_8288288_ENST00000382512_length(amino acids)=458AA_BP=262
MRAHGSRGWRRSRANSVSPWTKMTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHSLQSVDSGI
PTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTEREQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCS
VSSLGTELSTTLSVSNEDILDLVVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFARHPLFGRN
VPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAI
GSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQI

--------------------------------------------------------------

>89209_89209_3_TBC1D14-HTRA3_TBC1D14_chr4_6925838_ENST00000448507_HTRA3_chr4_8288288_ENST00000307358_length(amino acids)=532AA_BP=240
MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHSLQSVDSGIPTLEIGNPEPVPCSAVHVRRKQ
SDSDLIPERAFQSACALPSCAPPAPSSTEREQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFARHPLFGRNVPLSSGSGFIMSEAGLIITNAH
VVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREG
RELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDE

--------------------------------------------------------------

>89209_89209_4_TBC1D14-HTRA3_TBC1D14_chr4_6925838_ENST00000448507_HTRA3_chr4_8288288_ENST00000382512_length(amino acids)=436AA_BP=240
MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHSLQSVDSGIPTLEIGNPEPVPCSAVHVRRKQ
SDSDLIPERAFQSACALPSCAPPAPSSTEREQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFARHPLFGRNVPLSSGSGFIMSEAGLIITNAH
VVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREG

--------------------------------------------------------------

>89209_89209_5_TBC1D14-HTRA3_TBC1D14_chr4_6996029_ENST00000409757_HTRA3_chr4_8288287_ENST00000307358_length(amino acids)=634AA_BP=1
MRAHGSRGWRRSRANSVSPWTKMTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHSLQSVDSGI
PTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTEREQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCS
VSSLGTELSTTLSVSNEDILDLVVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFARNLLARKQ
SARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNVRKNLDFEPLSTTALILEDRPAHPLFGRNVPLSSGSGFI
MSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTV
TTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGI
RMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAP

--------------------------------------------------------------

>89209_89209_6_TBC1D14-HTRA3_TBC1D14_chr4_6996029_ENST00000409757_HTRA3_chr4_8288287_ENST00000382512_length(amino acids)=538AA_BP=1
MRAHGSRGWRRSRANSVSPWTKMTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHSLQSVDSGI
PTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTEREQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCS
VSSLGTELSTTLSVSNEDILDLVVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFARNLLARKQ
SARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNVRKNLDFEPLSTTALILEDRPAHPLFGRNVPLSSGSGFI
MSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTV

--------------------------------------------------------------

>89209_89209_7_TBC1D14-HTRA3_TBC1D14_chr4_6996029_ENST00000409757_HTRA3_chr4_8288288_ENST00000307358_length(amino acids)=634AA_BP=1
MRAHGSRGWRRSRANSVSPWTKMTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHSLQSVDSGI
PTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTEREQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCS
VSSLGTELSTTLSVSNEDILDLVVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFARNLLARKQ
SARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNVRKNLDFEPLSTTALILEDRPAHPLFGRNVPLSSGSGFI
MSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTV
TTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGI
RMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAP

--------------------------------------------------------------

>89209_89209_8_TBC1D14-HTRA3_TBC1D14_chr4_6996029_ENST00000409757_HTRA3_chr4_8288288_ENST00000382512_length(amino acids)=538AA_BP=1
MRAHGSRGWRRSRANSVSPWTKMTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHSLQSVDSGI
PTLEIGNPEPVPCSAVHVRRKQSDSDLIPERAFQSACALPSCAPPAPSSTEREQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCS
VSSLGTELSTTLSVSNEDILDLVVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFARNLLARKQ
SARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNVRKNLDFEPLSTTALILEDRPAHPLFGRNVPLSSGSGFI
MSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTV

--------------------------------------------------------------

>89209_89209_9_TBC1D14-HTRA3_TBC1D14_chr4_6996029_ENST00000410031_HTRA3_chr4_8288287_ENST00000307358_length(amino acids)=397AA_BP=1
MQPAPRSCEVTVDMMAISPALLFMDRNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNVRKNLD
FEPLSTTALILEDRPAHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPK
KKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTA
GISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPL

--------------------------------------------------------------

>89209_89209_10_TBC1D14-HTRA3_TBC1D14_chr4_6996029_ENST00000410031_HTRA3_chr4_8288287_ENST00000382512_length(amino acids)=301AA_BP=1
MQPAPRSCEVTVDMMAISPALLFMDRNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNVRKNLD
FEPLSTTALILEDRPAHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPK
KKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTA

--------------------------------------------------------------

>89209_89209_11_TBC1D14-HTRA3_TBC1D14_chr4_6996029_ENST00000410031_HTRA3_chr4_8288288_ENST00000307358_length(amino acids)=397AA_BP=1
MQPAPRSCEVTVDMMAISPALLFMDRNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNVRKNLD
FEPLSTTALILEDRPAHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPK
KKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTA
GISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPL

--------------------------------------------------------------

>89209_89209_12_TBC1D14-HTRA3_TBC1D14_chr4_6996029_ENST00000410031_HTRA3_chr4_8288288_ENST00000382512_length(amino acids)=301AA_BP=1
MQPAPRSCEVTVDMMAISPALLFMDRNLLARKQSARLDKHNDLGWKLFGKAPLRENAQKDSKRIQKEYEDKAGRPSKPPSPKQNVRKNLD
FEPLSTTALILEDRPAHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPK
KKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTA

--------------------------------------------------------------

>89209_89209_13_TBC1D14-HTRA3_TBC1D14_chr4_6996029_ENST00000448507_HTRA3_chr4_8288287_ENST00000307358_length(amino acids)=612AA_BP=0
MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHSLQSVDSGIPTLEIGNPEPVPCSAVHVRRKQ
SDSDLIPERAFQSACALPSCAPPAPSSTEREQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFARNLLARKQSARLDKHNDLGWKLFGKAPLRE
NAQKDSKRIQKEYEDKAGRPSKPPSPKQNVRKNLDFEPLSTTALILEDRPAHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPG
RQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDM
DYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPE

--------------------------------------------------------------

>89209_89209_14_TBC1D14-HTRA3_TBC1D14_chr4_6996029_ENST00000448507_HTRA3_chr4_8288287_ENST00000382512_length(amino acids)=516AA_BP=0
MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHSLQSVDSGIPTLEIGNPEPVPCSAVHVRRKQ
SDSDLIPERAFQSACALPSCAPPAPSSTEREQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFARNLLARKQSARLDKHNDLGWKLFGKAPLRE
NAQKDSKRIQKEYEDKAGRPSKPPSPKQNVRKNLDFEPLSTTALILEDRPAHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPG
RQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDM

--------------------------------------------------------------

>89209_89209_15_TBC1D14-HTRA3_TBC1D14_chr4_6996029_ENST00000448507_HTRA3_chr4_8288288_ENST00000307358_length(amino acids)=612AA_BP=0
MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHSLQSVDSGIPTLEIGNPEPVPCSAVHVRRKQ
SDSDLIPERAFQSACALPSCAPPAPSSTEREQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFARNLLARKQSARLDKHNDLGWKLFGKAPLRE
NAQKDSKRIQKEYEDKAGRPSKPPSPKQNVRKNLDFEPLSTTALILEDRPAHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPG
RQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDM
DYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPE

--------------------------------------------------------------

>89209_89209_16_TBC1D14-HTRA3_TBC1D14_chr4_6996029_ENST00000448507_HTRA3_chr4_8288288_ENST00000382512_length(amino acids)=516AA_BP=0
MTDGKLSTSTNGVAFMGILDGRPGNPLQNLQHVNLKAPRLLSAPEYGPKLKLRALEDRHSLQSVDSGIPTLEIGNPEPVPCSAVHVRRKQ
SDSDLIPERAFQSACALPSCAPPAPSSTEREQSVRKSSTFPRTGYDSVKLYSPTSKALTRSDDVSVCSVSSLGTELSTTLSVSNEDILDL
VVTSSSSAIVTLENDDDPQFTNVTLSSIKETRGLHQQDCVHEAEEGSKLKILGPFSNFFARNLLARKQSARLDKHNDLGWKLFGKAPLRE
NAQKDSKRIQKEYEDKAGRPSKPPSPKQNVRKNLDFEPLSTTALILEDRPAHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPG
RQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDM

--------------------------------------------------------------

>89209_89209_17_TBC1D14-HTRA3_TBC1D14_chr4_6996029_ENST00000451522_HTRA3_chr4_8288287_ENST00000307358_length(amino acids)=388AA_BP=1
MCLRAIERPAAPPRPASLRSRRVRPPARGPGGREGGRPSARWAWSLRPRASKAPAFMEYEDKAGRPSKPPSPKQNVRKNLDFEPLSTTAL
ILEDRPAHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLG
HSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSD
RITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEA

--------------------------------------------------------------

>89209_89209_18_TBC1D14-HTRA3_TBC1D14_chr4_6996029_ENST00000451522_HTRA3_chr4_8288287_ENST00000382512_length(amino acids)=292AA_BP=1
MCLRAIERPAAPPRPASLRSRRVRPPARGPGGREGGRPSARWAWSLRPRASKAPAFMEYEDKAGRPSKPPSPKQNVRKNLDFEPLSTTAL
ILEDRPAHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLG
HSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSD

--------------------------------------------------------------

>89209_89209_19_TBC1D14-HTRA3_TBC1D14_chr4_6996029_ENST00000451522_HTRA3_chr4_8288288_ENST00000307358_length(amino acids)=388AA_BP=1
MCLRAIERPAAPPRPASLRSRRVRPPARGPGGREGGRPSARWAWSLRPRASKAPAFMEYEDKAGRPSKPPSPKQNVRKNLDFEPLSTTAL
ILEDRPAHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLG
HSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSD
RITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEA

--------------------------------------------------------------

>89209_89209_20_TBC1D14-HTRA3_TBC1D14_chr4_6996029_ENST00000451522_HTRA3_chr4_8288288_ENST00000382512_length(amino acids)=292AA_BP=1
MCLRAIERPAAPPRPASLRSRRVRPPARGPGGREGGRPSARWAWSLRPRASKAPAFMEYEDKAGRPSKPPSPKQNVRKNLDFEPLSTTAL
ILEDRPAHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLG
HSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSD

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:6996029/chr4:8288288)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HTRA3

P83110

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724). {ECO:0000250|UniProtKB:Q9D236, ECO:0000269|PubMed:21321049, ECO:0000269|PubMed:22229724}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHTRA3chr4:6925838chr4:8288288ENST0000030735819359_444161.66666666666666454.0DomainPDZ
TgeneHTRA3chr4:6925838chr4:8288288ENST0000038251217359_444161.66666666666666358.0DomainPDZ
TgeneHTRA3chr4:6996029chr4:8288287ENST0000030735819359_444161.66666666666666454.0DomainPDZ
TgeneHTRA3chr4:6996029chr4:8288287ENST0000038251217359_444161.66666666666666358.0DomainPDZ
TgeneHTRA3chr4:6996029chr4:8288288ENST0000030735819359_444161.66666666666666454.0DomainPDZ
TgeneHTRA3chr4:6996029chr4:8288288ENST0000038251217359_444161.66666666666666358.0DomainPDZ
TgeneHTRA3chr4:6925838chr4:8288288ENST0000030735819175_340161.66666666666666454.0RegionNote=Serine protease
TgeneHTRA3chr4:6925838chr4:8288288ENST0000038251217175_340161.66666666666666358.0RegionNote=Serine protease
TgeneHTRA3chr4:6996029chr4:8288287ENST0000030735819175_340161.66666666666666454.0RegionNote=Serine protease
TgeneHTRA3chr4:6996029chr4:8288287ENST0000038251217175_340161.66666666666666358.0RegionNote=Serine protease
TgeneHTRA3chr4:6996029chr4:8288288ENST0000030735819175_340161.66666666666666454.0RegionNote=Serine protease
TgeneHTRA3chr4:6996029chr4:8288288ENST0000038251217175_340161.66666666666666358.0RegionNote=Serine protease

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBC1D14chr4:6925838chr4:8288288ENST00000409757+214401_611240.66666666666666694.0DomainRab-GAP TBC
HgeneTBC1D14chr4:6925838chr4:8288288ENST00000448507+214401_611240.66666666666666694.0DomainRab-GAP TBC
HgeneTBC1D14chr4:6925838chr4:8288288ENST00000451522+112401_6110414.0DomainRab-GAP TBC
HgeneTBC1D14chr4:6996029chr4:8288287ENST00000409757+414401_611320.6666666666667694.0DomainRab-GAP TBC
HgeneTBC1D14chr4:6996029chr4:8288287ENST00000448507+414401_611320.6666666666667694.0DomainRab-GAP TBC
HgeneTBC1D14chr4:6996029chr4:8288287ENST00000451522+212401_61140.666666666666664414.0DomainRab-GAP TBC
HgeneTBC1D14chr4:6996029chr4:8288288ENST00000409757+414401_611320.6666666666667694.0DomainRab-GAP TBC
HgeneTBC1D14chr4:6996029chr4:8288288ENST00000448507+414401_611320.6666666666667694.0DomainRab-GAP TBC
HgeneTBC1D14chr4:6996029chr4:8288288ENST00000451522+212401_61140.666666666666664414.0DomainRab-GAP TBC
TgeneHTRA3chr4:6925838chr4:8288288ENST000003073581921_77161.66666666666666454.0DomainIGFBP N-terminal
TgeneHTRA3chr4:6925838chr4:8288288ENST000003073581964_128161.66666666666666454.0DomainKazal-like
TgeneHTRA3chr4:6925838chr4:8288288ENST000003825121721_77161.66666666666666358.0DomainIGFBP N-terminal
TgeneHTRA3chr4:6925838chr4:8288288ENST000003825121764_128161.66666666666666358.0DomainKazal-like
TgeneHTRA3chr4:6996029chr4:8288287ENST000003073581921_77161.66666666666666454.0DomainIGFBP N-terminal
TgeneHTRA3chr4:6996029chr4:8288287ENST000003073581964_128161.66666666666666454.0DomainKazal-like
TgeneHTRA3chr4:6996029chr4:8288287ENST000003825121721_77161.66666666666666358.0DomainIGFBP N-terminal
TgeneHTRA3chr4:6996029chr4:8288287ENST000003825121764_128161.66666666666666358.0DomainKazal-like
TgeneHTRA3chr4:6996029chr4:8288288ENST000003073581921_77161.66666666666666454.0DomainIGFBP N-terminal
TgeneHTRA3chr4:6996029chr4:8288288ENST000003073581964_128161.66666666666666454.0DomainKazal-like
TgeneHTRA3chr4:6996029chr4:8288288ENST000003825121721_77161.66666666666666358.0DomainIGFBP N-terminal
TgeneHTRA3chr4:6996029chr4:8288288ENST000003825121764_128161.66666666666666358.0DomainKazal-like


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TBC1D14
HTRA3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TBC1D14-HTRA3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TBC1D14-HTRA3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource