UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TCF12-RGMA

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TCF12-RGMA
	FusionPDB ID: 89719
	FusionGDB2.0 ID: 89719
		Hgene	Tgene
	Gene symbol	TCF12	RGMA
	Gene ID	6938	56963
	Gene name	transcription factor 12	repulsive guidance molecule BMP co-receptor a
	Synonyms	CRS3\|HEB\|HTF4\|HsT17266\|TCF-12\|bHLHb20\|p64	RGM
	Cytomap	15q21.3	15q26.1
	Type of gene	protein-coding	protein-coding
	Description	transcription factor 12DNA-binding protein HTF4E-box-binding proteinclass B basic helix-loop-helix protein 20helix-loop-helix transcription factor 4transcription factor HTF-4	repulsive guidance molecule ARGM domain family, member Arepulsive guidance molecule family member a
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000267811, ENST00000333725, ENST00000438423, ENST00000452095, ENST00000557843, ENST00000343827, ENST00000537840, ENST00000543579, ENST00000559703, ENST00000559710, ENST00000560764,	ENST00000538818, ENST00000555584, ENST00000556087, ENST00000556658, ENST00000557301, ENST00000557420, ENST00000329082, ENST00000425933, ENST00000542321, ENST00000543599,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	29 X 19 X 12=6612	6 X 4 X 3=72
	# samples	32	7
	** MAII score	log2(32/6612*10)=-4.36894291440495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TCF12 [Title/Abstract] AND RGMA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TCF12(57384089)-RGMA(93595737), # samples:1
Anticipated loss of major functional domain due to fusion event.	TCF12-RGMA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TCF12-RGMA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TCF12-RGMA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TCF12-RGMA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TCF12	GO:0045944	positive regulation of transcription by RNA polymerase II	11802795
Tgene	RGMA	GO:0045944	positive regulation of transcription by RNA polymerase II	22728873

Fusion gene breakpoints across TCF12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RGMA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CG-4304-01A	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000438423	TCF12	chr15	57384089	-	ENST00000425933	RGMA	chr15	93595737	-	3436	621	260	1843	527
ENST00000438423	TCF12	chr15	57384089	-	ENST00000543599	RGMA	chr15	93595737	-	3436	621	260	1843	527
ENST00000438423	TCF12	chr15	57384089	-	ENST00000329082	RGMA	chr15	93595737	-	3435	621	260	1843	527
ENST00000438423	TCF12	chr15	57384089	-	ENST00000542321	RGMA	chr15	93595737	-	3426	621	260	1843	527
ENST00000267811	TCF12	chr15	57384089	-	ENST00000425933	RGMA	chr15	93595737	-	3444	629	304	1851	515
ENST00000267811	TCF12	chr15	57384089	-	ENST00000543599	RGMA	chr15	93595737	-	3444	629	304	1851	515
ENST00000267811	TCF12	chr15	57384089	-	ENST00000329082	RGMA	chr15	93595737	-	3443	629	304	1851	515
ENST00000267811	TCF12	chr15	57384089	-	ENST00000542321	RGMA	chr15	93595737	-	3434	629	304	1851	515
ENST00000452095	TCF12	chr15	57384089	-	ENST00000425933	RGMA	chr15	93595737	-	3422	607	294	1829	511
ENST00000452095	TCF12	chr15	57384089	-	ENST00000543599	RGMA	chr15	93595737	-	3422	607	294	1829	511
ENST00000452095	TCF12	chr15	57384089	-	ENST00000329082	RGMA	chr15	93595737	-	3421	607	294	1829	511
ENST00000452095	TCF12	chr15	57384089	-	ENST00000542321	RGMA	chr15	93595737	-	3412	607	294	1829	511
ENST00000333725	TCF12	chr15	57384089	-	ENST00000425933	RGMA	chr15	93595737	-	3375	560	235	1782	515
ENST00000333725	TCF12	chr15	57384089	-	ENST00000543599	RGMA	chr15	93595737	-	3375	560	235	1782	515
ENST00000333725	TCF12	chr15	57384089	-	ENST00000329082	RGMA	chr15	93595737	-	3374	560	235	1782	515
ENST00000333725	TCF12	chr15	57384089	-	ENST00000542321	RGMA	chr15	93595737	-	3365	560	235	1782	515
ENST00000557843	TCF12	chr15	57384089	-	ENST00000425933	RGMA	chr15	93595737	-	3227	412	51	1634	527
ENST00000557843	TCF12	chr15	57384089	-	ENST00000543599	RGMA	chr15	93595737	-	3227	412	51	1634	527
ENST00000557843	TCF12	chr15	57384089	-	ENST00000329082	RGMA	chr15	93595737	-	3226	412	51	1634	527
ENST00000557843	TCF12	chr15	57384089	-	ENST00000542321	RGMA	chr15	93595737	-	3217	412	51	1634	527

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000438423	ENST00000425933	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.011605936	0.988394
ENST00000438423	ENST00000543599	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.011605936	0.988394
ENST00000438423	ENST00000329082	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.011788376	0.9882116
ENST00000438423	ENST00000542321	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.011880542	0.98811954
ENST00000267811	ENST00000425933	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.011826488	0.98817354
ENST00000267811	ENST00000543599	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.011826488	0.98817354
ENST00000267811	ENST00000329082	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.012016733	0.9879832
ENST00000267811	ENST00000542321	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.012107404	0.98789257
ENST00000452095	ENST00000425933	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.012887239	0.9871128
ENST00000452095	ENST00000543599	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.012887239	0.9871128
ENST00000452095	ENST00000329082	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.013078871	0.9869212
ENST00000452095	ENST00000542321	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.013220558	0.98677945
ENST00000333725	ENST00000425933	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.012414072	0.9875859
ENST00000333725	ENST00000543599	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.012414072	0.9875859
ENST00000333725	ENST00000329082	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.012617677	0.98738235
ENST00000333725	ENST00000542321	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.012694141	0.9873059
ENST00000557843	ENST00000425933	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.011875963	0.9881241
ENST00000557843	ENST00000543599	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.011875963	0.9881241
ENST00000557843	ENST00000329082	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.012076105	0.9879239
ENST00000557843	ENST00000542321	TCF12	chr15	57384089	-	RGMA	chr15	93595737	-	0.012147463	0.9878526

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>89719_89719_1_TCF12-RGMA_TCF12_chr15_57384089_ENST00000267811_RGMA_chr15_93595737_ENST00000329082_length(amino acids)=515AA_BP=108
MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTDSPHYSDHLNDSR
LGAHEGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAVHGIEDLMSQHNC
SKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNNYLNVQVTNTPVL
PGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVR
MPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTT

--------------------------------------------------------------

>89719_89719_2_TCF12-RGMA_TCF12_chr15_57384089_ENST00000267811_RGMA_chr15_93595737_ENST00000425933_length(amino acids)=515AA_BP=108
MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTDSPHYSDHLNDSR
LGAHEGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAVHGIEDLMSQHNC
SKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNNYLNVQVTNTPVL
PGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVR
MPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTT

--------------------------------------------------------------

>89719_89719_3_TCF12-RGMA_TCF12_chr15_57384089_ENST00000267811_RGMA_chr15_93595737_ENST00000542321_length(amino acids)=515AA_BP=108
MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTDSPHYSDHLNDSR
LGAHEGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAVHGIEDLMSQHNC
SKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNNYLNVQVTNTPVL
PGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVR
MPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTT

--------------------------------------------------------------

>89719_89719_4_TCF12-RGMA_TCF12_chr15_57384089_ENST00000267811_RGMA_chr15_93595737_ENST00000543599_length(amino acids)=515AA_BP=108
MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTDSPHYSDHLNDSR
LGAHEGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAVHGIEDLMSQHNC
SKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNNYLNVQVTNTPVL
PGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVR
MPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTT

--------------------------------------------------------------

>89719_89719_5_TCF12-RGMA_TCF12_chr15_57384089_ENST00000333725_RGMA_chr15_93595737_ENST00000329082_length(amino acids)=515AA_BP=108
MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTDSPHYSDHLNDSR
LGAHEGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAVHGIEDLMSQHNC
SKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNNYLNVQVTNTPVL
PGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVR
MPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTT

--------------------------------------------------------------

>89719_89719_6_TCF12-RGMA_TCF12_chr15_57384089_ENST00000333725_RGMA_chr15_93595737_ENST00000425933_length(amino acids)=515AA_BP=108
MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTDSPHYSDHLNDSR
LGAHEGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAVHGIEDLMSQHNC
SKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNNYLNVQVTNTPVL
PGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVR
MPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTT

--------------------------------------------------------------

>89719_89719_7_TCF12-RGMA_TCF12_chr15_57384089_ENST00000333725_RGMA_chr15_93595737_ENST00000542321_length(amino acids)=515AA_BP=108
MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTDSPHYSDHLNDSR
LGAHEGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAVHGIEDLMSQHNC
SKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNNYLNVQVTNTPVL
PGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVR
MPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTT

--------------------------------------------------------------

>89719_89719_8_TCF12-RGMA_TCF12_chr15_57384089_ENST00000333725_RGMA_chr15_93595737_ENST00000543599_length(amino acids)=515AA_BP=108
MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTDSPHYSDHLNDSR
LGAHEGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAVHGIEDLMSQHNC
SKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNNYLNVQVTNTPVL
PGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVR
MPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTT

--------------------------------------------------------------

>89719_89719_9_TCF12-RGMA_TCF12_chr15_57384089_ENST00000438423_RGMA_chr15_93595737_ENST00000329082_length(amino acids)=527AA_BP=120
MDAETGRQKWPKMNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTD
SPHYSDHLNDSRLGAHEGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAV
HGIEDLMSQHNCSKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNN
YLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVV
RQVGRYLTFAVRMPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDL

--------------------------------------------------------------

>89719_89719_10_TCF12-RGMA_TCF12_chr15_57384089_ENST00000438423_RGMA_chr15_93595737_ENST00000425933_length(amino acids)=527AA_BP=120
MDAETGRQKWPKMNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTD
SPHYSDHLNDSRLGAHEGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAV
HGIEDLMSQHNCSKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNN
YLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVV
RQVGRYLTFAVRMPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDL

--------------------------------------------------------------

>89719_89719_11_TCF12-RGMA_TCF12_chr15_57384089_ENST00000438423_RGMA_chr15_93595737_ENST00000542321_length(amino acids)=527AA_BP=120
MDAETGRQKWPKMNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTD
SPHYSDHLNDSRLGAHEGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAV
HGIEDLMSQHNCSKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNN
YLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVV
RQVGRYLTFAVRMPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDL

--------------------------------------------------------------

>89719_89719_12_TCF12-RGMA_TCF12_chr15_57384089_ENST00000438423_RGMA_chr15_93595737_ENST00000543599_length(amino acids)=527AA_BP=120
MDAETGRQKWPKMNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTD
SPHYSDHLNDSRLGAHEGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAV
HGIEDLMSQHNCSKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNN
YLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVV
RQVGRYLTFAVRMPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDL

--------------------------------------------------------------

>89719_89719_13_TCF12-RGMA_TCF12_chr15_57384089_ENST00000452095_RGMA_chr15_93595737_ENST00000329082_length(amino acids)=511AA_BP=104
MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGTIHEMKQLNSKARQKGQRIKGFTDSPHYSDHLNDSRLGAH
EGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAVHGIEDLMSQHNCSKDG
PTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNNYLNVQVTNTPVLPGSA
ATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVRMPEE
VVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTTGDVN

--------------------------------------------------------------

>89719_89719_14_TCF12-RGMA_TCF12_chr15_57384089_ENST00000452095_RGMA_chr15_93595737_ENST00000425933_length(amino acids)=511AA_BP=104
MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGTIHEMKQLNSKARQKGQRIKGFTDSPHYSDHLNDSRLGAH
EGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAVHGIEDLMSQHNCSKDG
PTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNNYLNVQVTNTPVLPGSA
ATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVRMPEE
VVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTTGDVN

--------------------------------------------------------------

>89719_89719_15_TCF12-RGMA_TCF12_chr15_57384089_ENST00000452095_RGMA_chr15_93595737_ENST00000542321_length(amino acids)=511AA_BP=104
MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGTIHEMKQLNSKARQKGQRIKGFTDSPHYSDHLNDSRLGAH
EGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAVHGIEDLMSQHNCSKDG
PTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNNYLNVQVTNTPVLPGSA
ATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVRMPEE
VVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTTGDVN

--------------------------------------------------------------

>89719_89719_16_TCF12-RGMA_TCF12_chr15_57384089_ENST00000452095_RGMA_chr15_93595737_ENST00000543599_length(amino acids)=511AA_BP=104
MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGTIHEMKQLNSKARQKGQRIKGFTDSPHYSDHLNDSRLGAH
EGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAVHGIEDLMSQHNCSKDG
PTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNNYLNVQVTNTPVLPGSA
ATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVRMPEE
VVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTTGDVN

--------------------------------------------------------------

>89719_89719_17_TCF12-RGMA_TCF12_chr15_57384089_ENST00000557843_RGMA_chr15_93595737_ENST00000329082_length(amino acids)=527AA_BP=120
MDAETGRQKWPKMNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTD
SPHYSDHLNDSRLGAHEGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAV
HGIEDLMSQHNCSKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNN
YLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVV
RQVGRYLTFAVRMPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDL

--------------------------------------------------------------

>89719_89719_18_TCF12-RGMA_TCF12_chr15_57384089_ENST00000557843_RGMA_chr15_93595737_ENST00000425933_length(amino acids)=527AA_BP=120
MDAETGRQKWPKMNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTD
SPHYSDHLNDSRLGAHEGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAV
HGIEDLMSQHNCSKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNN
YLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVV
RQVGRYLTFAVRMPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDL

--------------------------------------------------------------

>89719_89719_19_TCF12-RGMA_TCF12_chr15_57384089_ENST00000557843_RGMA_chr15_93595737_ENST00000542321_length(amino acids)=527AA_BP=120
MDAETGRQKWPKMNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTD
SPHYSDHLNDSRLGAHEGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAV
HGIEDLMSQHNCSKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNN
YLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVV
RQVGRYLTFAVRMPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDL

--------------------------------------------------------------

>89719_89719_20_TCF12-RGMA_TCF12_chr15_57384089_ENST00000557843_RGMA_chr15_93595737_ENST00000543599_length(amino acids)=527AA_BP=120
MDAETGRQKWPKMNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGIDERGGTTSWGTSGQPSPSYDSSRGFTD
SPHYSDHLNDSRLGAHEGLSPTPFMNSNLMATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAV
HGIEDLMSQHNCSKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNN
YLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVV
RQVGRYLTFAVRMPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDL

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:57384089/chr15:93595737)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000267811

19_27

108.33333333333333

1821.3333333333333

Motif

Note=9aaTAD

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000333725

19_27

108.33333333333333

1420.0

Motif

Note=9aaTAD

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000438423

19_27

108.33333333333333

1398.3333333333333

Motif

Note=9aaTAD

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000557843

19_27

108.33333333333333

1301.0

Motif

Note=9aaTAD

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000267811

577_630

108.33333333333333

1821.3333333333333

Domain

bHLH

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000333725

577_630

108.33333333333333

1420.0

Domain

bHLH

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000343827

577_630

1254.6666666666667

Domain

bHLH

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000438423

577_630

108.33333333333333

1398.3333333333333

Domain

bHLH

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000557843

577_630

108.33333333333333

1301.0

Domain

bHLH

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000343827

19_27

1254.6666666666667

Motif

Note=9aaTAD

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000267811

119_140

108.33333333333333

1821.3333333333333

Region

Note=Leucine-zipper

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000267811

632_655

108.33333333333333

1821.3333333333333

Region

Note=Class A specific domain

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000333725

119_140

108.33333333333333

1420.0

Region

Note=Leucine-zipper

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000333725

632_655

108.33333333333333

1420.0

Region

Note=Class A specific domain

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000343827

119_140

1254.6666666666667

Region

Note=Leucine-zipper

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000343827

632_655

1254.6666666666667

Region

Note=Class A specific domain

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000438423

119_140

108.33333333333333

1398.3333333333333

Region

Note=Leucine-zipper

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000438423

632_655

108.33333333333333

1398.3333333333333

Region

Note=Class A specific domain

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000557843

119_140

108.33333333333333

1301.0

Region

Note=Leucine-zipper

Hgene

TCF12

chr15:57384089

chr15:93595737

ENST00000557843

632_655

108.33333333333333

1301.0

Region

Note=Class A specific domain

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TCF12
RGMA

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	TCF12	chr15:57384089	chr15:93595737	ENST00000267811	-	5	20	182_196	108.33333333333333	1821.3333333333333	RUNX1T1
Hgene	TCF12	chr15:57384089	chr15:93595737	ENST00000333725	-	5	21	182_196	108.33333333333333	1420.0	RUNX1T1
Hgene	TCF12	chr15:57384089	chr15:93595737	ENST00000343827	-	1	13	182_196	0	1254.6666666666667	RUNX1T1
Hgene	TCF12	chr15:57384089	chr15:93595737	ENST00000438423	-	5	21	182_196	108.33333333333333	1398.3333333333333	RUNX1T1
Hgene	TCF12	chr15:57384089	chr15:93595737	ENST00000557843	-	5	20	182_196	108.33333333333333	1301.0	RUNX1T1

Top

Related Drugs to TCF12-RGMA

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to TCF12-RGMA

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source