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level3

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TCF3-PBX1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TCF3-PBX1
	FusionPDB ID: 89775
	FusionGDB2.0 ID: 89775
		Hgene	Tgene
	Gene symbol	TCF3	PBX1
	Gene ID	83439	5087
	Gene name	transcription factor 7 like 1	PBX homeobox 1
	Synonyms	TCF-3\|TCF3	CAKUHED
	Cytomap	2p11.2	1q23.3
	Type of gene	protein-coding	protein-coding
	Description	transcription factor 7-like 1HMG box transcription factor 3transcription factor 7-like 1 (T-cell specific, HMG-box)	pre-B-cell leukemia transcription factor 1homeobox protein PBX1homeobox protein PRLpre-B-cell leukemia homeobox 1
	Modification date	20200313	20200313
	UniProtAcc	TFPT	P40424
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000262965, ENST00000344749, ENST00000395423, ENST00000453954, ENST00000588136,	ENST00000560641, ENST00000474046, ENST00000485769, ENST00000540246, ENST00000367897, ENST00000401534, ENST00000420696, ENST00000540236, ENST00000559240,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	21 X 26 X 9=4914	13 X 13 X 8=1352
	# samples	27	17
	** MAII score	log2(27/4914*10)=-4.18586654531133 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/1352*10)=-2.99148850014448 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TCF3 [Title/Abstract] AND PBX1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TCF3(1619110)-PBX1(164761730), # samples:2
Anticipated loss of major functional domain due to fusion event.	TCF3-PBX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TCF3-PBX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TCF3-PBX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TCF3-PBX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TCF3-PBX1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. TCF3-PBX1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. TCF3-PBX1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. TCF3-PBX1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. TCF3-PBX1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TCF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PBX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	acute myeloid leukemia;acute lymphoblastic lekemia;lymphoblastic lymphoma;acute non lymphocytic leukemia;B cell acute lymphoblastic leukemia	AY311345	TCF3	chr19	1619803		PBX1	chr1	164761730
ChimerKB3	.	.	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+
ChiTaRS5.0	N/A	AY311345	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+
ChiTaRS5.0	N/A	M31522	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000453954	TCF3	chr19	1615684	-	ENST00000420696	PBX1	chr1	164761730	+	7561	1378	17	1474	485
ENST00000453954	TCF3	chr19	1615684	-	ENST00000401534	PBX1	chr1	164761730	+	2157	1378	17	1474	485
ENST00000453954	TCF3	chr19	1615684	-	ENST00000559240	PBX1	chr1	164761730	+	2133	1378	17	1474	485
ENST00000453954	TCF3	chr19	1615684	-	ENST00000367897	PBX1	chr1	164761730	+	2572	1378	17	1474	485
ENST00000453954	TCF3	chr19	1615684	-	ENST00000540236	PBX1	chr1	164761730	+	2376	1378	17	1474	485
ENST00000588136	TCF3	chr19	1615684	-	ENST00000420696	PBX1	chr1	164761730	+	8266	2083	497	2179	560
ENST00000588136	TCF3	chr19	1615684	-	ENST00000401534	PBX1	chr1	164761730	+	2862	2083	497	2179	560
ENST00000588136	TCF3	chr19	1615684	-	ENST00000559240	PBX1	chr1	164761730	+	2838	2083	497	2179	560
ENST00000588136	TCF3	chr19	1615684	-	ENST00000367897	PBX1	chr1	164761730	+	3277	2083	497	2179	560
ENST00000588136	TCF3	chr19	1615684	-	ENST00000540236	PBX1	chr1	164761730	+	3081	2083	497	2179	560
ENST00000395423	TCF3	chr19	1619110	-	ENST00000420696	PBX1	chr1	164761730	+	7508	1325	28	2352	774
ENST00000395423	TCF3	chr19	1619110	-	ENST00000401534	PBX1	chr1	164761730	+	2104	1325	28	2103	692
ENST00000395423	TCF3	chr19	1619110	-	ENST00000559240	PBX1	chr1	164761730	+	2080	1325	28	2079	684
ENST00000395423	TCF3	chr19	1619110	-	ENST00000367897	PBX1	chr1	164761730	+	2519	1325	28	2103	691
ENST00000395423	TCF3	chr19	1619110	-	ENST00000540236	PBX1	chr1	164761730	+	2323	1325	28	2322	765

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000395423	ENST00000420696	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+	0.000736779	0.9992632
ENST00000395423	ENST00000401534	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+	0.02915048	0.9708495
ENST00000395423	ENST00000559240	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+	0.03946733	0.9605326
ENST00000395423	ENST00000367897	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+	0.023425095	0.97657496
ENST00000395423	ENST00000540236	TCF3	chr19	1619110	-	PBX1	chr1	164761730	+	0.02026107	0.97973895

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>89775_89775_1_TCF3-PBX1_TCF3_chr19_1615684_ENST00000453954_PBX1_chr1_164761730_ENST00000367897_length(amino acids)=485AA_BP=453
MVRSLCCAQMCRRGPWHGQCTHSARQSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGS
LDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGP
VGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHS
SNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSL
GGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPR

--------------------------------------------------------------

>89775_89775_2_TCF3-PBX1_TCF3_chr19_1615684_ENST00000453954_PBX1_chr1_164761730_ENST00000401534_length(amino acids)=485AA_BP=453
MVRSLCCAQMCRRGPWHGQCTHSARQSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGS
LDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGP
VGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHS
SNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSL
GGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPR

--------------------------------------------------------------

>89775_89775_3_TCF3-PBX1_TCF3_chr19_1615684_ENST00000453954_PBX1_chr1_164761730_ENST00000420696_length(amino acids)=485AA_BP=453
MVRSLCCAQMCRRGPWHGQCTHSARQSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGS
LDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGP
VGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHS
SNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSL
GGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPR

--------------------------------------------------------------

>89775_89775_4_TCF3-PBX1_TCF3_chr19_1615684_ENST00000453954_PBX1_chr1_164761730_ENST00000540236_length(amino acids)=485AA_BP=453
MVRSLCCAQMCRRGPWHGQCTHSARQSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGS
LDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGP
VGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHS
SNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSL
GGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPR

--------------------------------------------------------------

>89775_89775_5_TCF3-PBX1_TCF3_chr19_1615684_ENST00000453954_PBX1_chr1_164761730_ENST00000559240_length(amino acids)=485AA_BP=453
MVRSLCCAQMCRRGPWHGQCTHSARQSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGS
LDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGP
VGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHS
SNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSL
GGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPR

--------------------------------------------------------------

>89775_89775_6_TCF3-PBX1_TCF3_chr19_1615684_ENST00000588136_PBX1_chr1_164761730_ENST00000367897_length(amino acids)=560AA_BP=528
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGLEDRPSSGSWGSGDQSSSSFDPSRTFSEGTHFTESHSSLSS
STFLGPGLGGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGL
PSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQ
HERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSP
QGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPED
GLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSFEYPRSPGGGT

--------------------------------------------------------------

>89775_89775_7_TCF3-PBX1_TCF3_chr19_1615684_ENST00000588136_PBX1_chr1_164761730_ENST00000401534_length(amino acids)=560AA_BP=528
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGLEDRPSSGSWGSGDQSSSSFDPSRTFSEGTHFTESHSSLSS
STFLGPGLGGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGL
PSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQ
HERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSP
QGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPED
GLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSFEYPRSPGGGT

--------------------------------------------------------------

>89775_89775_8_TCF3-PBX1_TCF3_chr19_1615684_ENST00000588136_PBX1_chr1_164761730_ENST00000420696_length(amino acids)=560AA_BP=528
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGLEDRPSSGSWGSGDQSSSSFDPSRTFSEGTHFTESHSSLSS
STFLGPGLGGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGL
PSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQ
HERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSP
QGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPED
GLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSFEYPRSPGGGT

--------------------------------------------------------------

>89775_89775_9_TCF3-PBX1_TCF3_chr19_1615684_ENST00000588136_PBX1_chr1_164761730_ENST00000540236_length(amino acids)=560AA_BP=528
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGLEDRPSSGSWGSGDQSSSSFDPSRTFSEGTHFTESHSSLSS
STFLGPGLGGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGL
PSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQ
HERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSP
QGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPED
GLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSFEYPRSPGGGT

--------------------------------------------------------------

>89775_89775_10_TCF3-PBX1_TCF3_chr19_1615684_ENST00000588136_PBX1_chr1_164761730_ENST00000559240_length(amino acids)=560AA_BP=528
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGLEDRPSSGSWGSGDQSSSSFDPSRTFSEGTHFTESHSSLSS
STFLGPGLGGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGL
PSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQ
HERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSP
QGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPED
GLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSFEYPRSPGGGT

--------------------------------------------------------------

>89775_89775_11_TCF3-PBX1_TCF3_chr19_1619110_ENST00000395423_PBX1_chr1_164761730_ENST00000367897_length(amino acids)=691AA_BP=432
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPS
GMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPP
GQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSR
GTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGT
AGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSVLSIRGAQEEEPTDPQLM
RLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKE
IERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGN

--------------------------------------------------------------

>89775_89775_12_TCF3-PBX1_TCF3_chr19_1619110_ENST00000395423_PBX1_chr1_164761730_ENST00000401534_length(amino acids)=692AA_BP=432
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPS
GMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPP
GQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSR
GTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGT
AGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSVLSIRGAQEEEPTDPQLM
RLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKE
IERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGN

--------------------------------------------------------------

>89775_89775_13_TCF3-PBX1_TCF3_chr19_1619110_ENST00000395423_PBX1_chr1_164761730_ENST00000420696_length(amino acids)=774AA_BP=432
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPS
GMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPP
GQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSR
GTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGT
AGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSVLSIRGAQEEEPTDPQLM
RLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKE
IERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGN
KRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRH

--------------------------------------------------------------

>89775_89775_14_TCF3-PBX1_TCF3_chr19_1619110_ENST00000395423_PBX1_chr1_164761730_ENST00000540236_length(amino acids)=765AA_BP=432
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPS
GMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPP
GQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSR
GTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGT
AGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSVLSIRGAQEEEPTDPQLM
RLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKE
IERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGN
KRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRH

--------------------------------------------------------------

>89775_89775_15_TCF3-PBX1_TCF3_chr19_1619110_ENST00000395423_PBX1_chr1_164761730_ENST00000559240_length(amino acids)=684AA_BP=432
MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGKSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPS
GMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSAELWSPP
GQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSR
GTTAGSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGT
AGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSVLSIRGAQEEEPTDPQLM
RLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKE
IERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVDTLRHV

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:1619110/chr1:164761730)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TCF3 TFPT	PBX1 P40424
253	FUNCTION: Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 (PubMed:9191052). Binds to the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein (PubMed:9191052). Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 (PubMed:8327485, PubMed:7791786). Acts as a transcriptional activator of PF4 in complex with MEIS1 (PubMed:12609849). Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence (By similarity). In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development (By similarity). Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1) (By similarity). Probably in complex with MEIS2, involved in transcriptional regulation by KLF4 (PubMed:21746878). Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B (By similarity). Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression (By similarity). {ECO:0000250\|UniProtKB:P41778, ECO:0000269\|PubMed:12609849, ECO:0000269\|PubMed:21746878, ECO:0000269\|PubMed:7791786, ECO:0000269\|PubMed:8327485, ECO:0000269\|PubMed:9191052}.; FUNCTION: [Isoform PBX1b]: As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. {ECO:0000250\|UniProtKB:P41778}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000262965

170_176

483.3333333333333

655.0

Motif

Nuclear localization signal

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000262965

19_27

483.3333333333333

655.0

Motif

Note=9aaTAD

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000344749

170_176

483.3333333333333

652.0

Motif

Nuclear localization signal

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000344749

19_27

483.3333333333333

652.0

Motif

Note=9aaTAD

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000588136

170_176

483.3333333333333

527.0

Motif

Nuclear localization signal

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000588136

19_27

483.3333333333333

527.0

Motif

Note=9aaTAD

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000262965

389_425

483.3333333333333

655.0

Region

Note=Leucine-zipper

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000344749

389_425

483.3333333333333

652.0

Region

Note=Leucine-zipper

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000588136

389_425

483.3333333333333

527.0

Region

Note=Leucine-zipper

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000367897

127_135

88.33333333333333

408.3333333333333

Compositional bias

Note=Poly-Ala

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000401534

127_135

88.33333333333333

348.0

Compositional bias

Note=Poly-Ala

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000420696

127_135

88.33333333333333

431.0

Compositional bias

Note=Poly-Ala

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000540236

127_135

88.33333333333333

421.0

Compositional bias

Note=Poly-Ala

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000367897

233_295

88.33333333333333

408.3333333333333

DNA binding

Homeobox%3B TALE-type

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000401534

233_295

88.33333333333333

348.0

DNA binding

Homeobox%3B TALE-type

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000420696

233_295

88.33333333333333

431.0

DNA binding

Homeobox%3B TALE-type

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000540236

233_295

88.33333333333333

421.0

DNA binding

Homeobox%3B TALE-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000262965

549_602

483.3333333333333

655.0

Domain

bHLH

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000344749

549_602

483.3333333333333

652.0

Domain

bHLH

Hgene

TCF3

chr19:1619110

chr1:164761730

ENST00000588136

549_602

483.3333333333333

527.0

Domain

bHLH

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000367897

40_232

88.33333333333333

408.3333333333333

Domain

PBC

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000401534

40_232

88.33333333333333

348.0

Domain

PBC

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000420696

40_232

88.33333333333333

431.0

Domain

PBC

Tgene

PBX1

chr19:1619110

chr1:164761730

ENST00000540236

40_232

88.33333333333333

421.0

Domain

PBC

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (274) >>>274.pdbFusion protein BP residue: 453 CIF file (274) >>>274.cif	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+	MVRSLCCAQMCRRGPWHGQCTHSARQSGERGAYASFGRDAGVGGLTQAGF LSGELALNSPGPLSPSGMKGTSQYYPSYSGSSRRRAADGSLDTQPKKVRK VPPGLPSSVYPPSSGEDYGRDATAYPSAKTPSSTYPAPFYVADGSLHPSA ELWSPPGQAGFGPMLGGGSSPLPLPPGSGPVGSSGSSSTFGGLHQHERMG YQLHGAEVNGGLPSASSFSSAPGATYGGVSSHTPPVSGADSLLGSRGTTA GSSGDALGKALASIYSPDHSSNNFSSSPSTPVGSPQGLAGTSQWPRAGAP GALSPSYDGGLHGLQSKIEDHLDEAIHVLRSHAVGTAGDMHTLLPGHGAL ASGFTGPMSLGGRHAGLVGGSHPEDGLAGSTSLMHNHAALPSQPGTLPDL SRPPDSYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPR	485
3D view using mol* of 274 (AA BP:453)


PDB file (408) >>>408.pdbFusion protein BP residue: 528 CIF file (408) >>>408.cif	TCF3	chr19	1615684	-	PBX1	chr1	164761730	+	MNQPQRMAPVGTDKELSDLLDFSMMFPLPVTNGKGRPASLAGAQFGGSGL EDRPSSGSWGSGDQSSSSFDPSRTFSEGTHFTESHSSLSSSTFLGPGLGG KSGERGAYASFGRDAGVGGLTQAGFLSGELALNSPGPLSPSGMKGTSQYY PSYSGSSRRRAADGSLDTQPKKVRKVPPGLPSSVYPPSSGEDYGRDATAY PSAKTPSSTYPAPFYVADGSLHPSAELWSPPGQAGFGPMLGGGSSPLPLP PGSGPVGSSGSSSTFGGLHQHERMGYQLHGAEVNGGLPSASSFSSAPGAT YGGVSSHTPPVSGADSLLGSRGTTAGSSGDALGKALASIYSPDHSSNNFS SSPSTPVGSPQGLAGTSQWPRAGAPGALSPSYDGGLHGLQSKIEDHLDEA IHVLRSHAVGTAGDMHTLLPGHGALASGFTGPMSLGGRHAGLVGGSHPED GLAGSTSLMHNHAALPSQPGTLPDLSRPPDSYSGLGRAGATAAASEIKRE EKEDEENTSAADHSEEEKKELKAPRARTSFEYPRSPGGGTHRPPADAAGQ	560
3D view using mol* of 408 (AA BP:528)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

TCF3_pLDDT.png

PBX1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

TCF3_PBX1_274_pLDDT.png (AA BP:453)

TCF3_PBX1_274_pLDDT_and_active_sites.png (AA BP:453)

TCF3_PBX1_274_violinplot.png (AA BP:453)

TCF3_PBX1_408_pLDDT.png (AA BP:528)

TCF3_PBX1_408_pLDDT_and_active_sites.png (AA BP:528)

TCF3_PBX1_408_violinplot.png (AA BP:528)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

TCF3_PBX1_274.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
274	0.512	13	0.489	38.759	0.874	0.503	0.727	0.625	0.466	1.341	1.26	Chain A: 10,11,13,14,16
408	0.481	16	0.405	25.382	0.758	0.542	0.842	0.46	0.909	0.506	0.348	Chain A: 250,251,268,269,270

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB

ZINC ID

DrugBank ID

Drug name

Docking score

Glide gscore

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID

DrugBank ID

Drug name

Drug type

SMILES

Drug group

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID

mol_MW

dipole

SASA

FOSA

FISA

PISA

WPSA

volume

donorHB

accptHB

Human Oral Absorption

Percent Human Oral Absorption

Rule Of Five

Rule Of Three

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID

Smile

Surface Accessibility

Toxicity

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

TCF3

HAND2, ID3, SKP2, NHLH1, TCF3, EP300, CREBBP, KAT2B, CALM1, LMX1A, TAL1, LDB1, CBFA2T3, ELK3, MYOD1, ID1, ID2, MYF5, MYF6, MYOG, UBE2I, LYL1, MAPKAPK3, TWIST1, DAXX, MEN1, TCF4, RUNX1T1, RUNX1, TRIM33, INO80E, YY1, RB1, ASB2, SOX2, ELAVL1, ID4, KDM1A, PRMT5, MRPL37, RPL23A, UQCRC2, MRPL49, DDX17, SAFB, EIF5A, MYO1B, GSE1, SLC25A10, BHLHA15, PIP, ALDH18A1, SF3A3, DNAJC10, RPL36A, IMMT, RPS13, DDX20, TET2, PRPF8, RCOR1, TCF24, RPL14, PON2, SSBP1, RPL31, MRPL44, C14orf166, SPIN1, CCT2, MYL6B, CHCHD3, ATP2A3, LANCL2, SLC9A3R1, TIMM50, ERLIN2, MRPL39, ATOH8, SERPINH1, SETSIP, SON, FBL, SLC25A4, EEF1A2, LGALS7, C1QBP, CPD, MRPL23, NHLH2, RPL13, COX7A2, CSTA, PCBP1, NDUFB4, TFF3, FLG2, HNRNPR, ERAL1, RPN2, RBM39, RPL24, LBR, CASP14, STK38, CANX, TCF12, FOXH1, Ube2i, TLE1, KAT2A, TRRAP, SUPT3H, TADA2A, Myod1, Tfap4, Tcf12, Scx, Twist2, Usf1, Rpa1, Ncl, USF1, SCX, TCF21, RPL37, MAPKAPK2, RNF14, FAM115A, PTF1A, Crebbp, HAND1, NEUROD1, MESP2, Bhlhe40, BHLHE40, PARP1, Tcf15, Tcf3, PSMD4, NEDD9, XPO1, BCOR, KIF18A, Id2, Kif13b, Dctn3, ATOH1, FERD3L, NEUROG3, FKBP9, COLGALT2, HNRNPL, EGLN3, OLIG1, OLIG2, IRF2BP2, ASCL1, Neurod1, Neurog1, Neurog2, Ascl1, TRAPPC2L, KHSRP, CARM1, HMGCR, NPRL3, TBL1XR1, VPS45, VPS51, RABGEF1, TRAPPC13, CUL5, TRAPPC2, NPRL2, TRAPPC9, POLE3, B3GNT2, ARL5A, SLC30A5, SAR1A, MOGS, RICTOR, HNRNPD, B4GALT3, SEC23IP, CAND1, CBL, MAN1B1, GCNT2, CTBP1, MAN2A1, TRAPPC12, SEC31A, HIST1H4A, APEX1, GLIS1, AURKA, DACH1, WHSC1L1, ASCL3, TWIST2, nsp5ab, DDX58, NEUROG1, TCF15, TCF23, TAL2, FIGLA, MSGN1, NEUROD4, ASCL4, MSC, USP7,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TCF3
PBX1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to TCF3-PBX1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Drug	Source	PMID
TCF3	PBX1	Intensive Chemotherapy	PubMed	25551271

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Related Diseases to TCF3-PBX1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
TCF3	PBX1	Children With Precursor B Acute Lymphoblastic Leukemia	PubMed	25551271
TCF3	PBX1	Breast Invasive Ductal Carcinoma Esophageal Adenocarcinoma	MyCancerGenome

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TCF3	C0006413	Burkitt Lymphoma	2	CTD_human;ORPHANET
Hgene	TCF3	C0343640	African Burkitt's lymphoma	2	CTD_human
Hgene	TCF3	C4721444	Burkitt Leukemia	2	CTD_human
Hgene	TCF3	C0001768	Agammaglobulinemia	1	CTD_human;GENOMICS_ENGLAND
Hgene	TCF3	C0023452	Childhood Acute Lymphoblastic Leukemia	1	CTD_human
Hgene	TCF3	C0023453	L2 Acute Lymphoblastic Leukemia	1	CTD_human
Hgene	TCF3	C0023485	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1	CTD_human
Hgene	TCF3	C0398686	Primary immune deficiency disorder	1	GENOMICS_ENGLAND
Hgene	TCF3	C1832241	Agammaglobulinemia, non-Bruton type	1	ORPHANET
Hgene	TCF3	C1844383	Recurrent bacterial infection	1	GENOMICS_ENGLAND
Hgene	TCF3	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	1	CTD_human
Hgene	TCF3	C4310786	AGAMMAGLOBULINEMIA 8, AUTOSOMAL DOMINANT	1	GENOMICS_ENGLAND
Tgene	PBX1	C0006413	Burkitt Lymphoma	2	CTD_human;ORPHANET
Tgene	PBX1	C0343640	African Burkitt's lymphoma	2	CTD_human
Tgene	PBX1	C1968949	Cakut	2	GENOMICS_ENGLAND
Tgene	PBX1	C4721444	Burkitt Leukemia	2	CTD_human
Tgene	PBX1	C0013146	Drug abuse	1	CTD_human
Tgene	PBX1	C0013170	Drug habituation	1	CTD_human
Tgene	PBX1	C0013222	Drug Use Disorders	1	CTD_human
Tgene	PBX1	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Tgene	PBX1	C0038580	Substance Dependence	1	CTD_human
Tgene	PBX1	C0038586	Substance Use Disorders	1	CTD_human
Tgene	PBX1	C0236969	Substance-Related Disorders	1	CTD_human
Tgene	PBX1	C0431692	Bilateral renal hypoplasia	1	ORPHANET
Tgene	PBX1	C0740858	Substance abuse problem	1	CTD_human
Tgene	PBX1	C1510472	Drug Dependence	1	CTD_human
Tgene	PBX1	C4316881	Prescription Drug Abuse	1	CTD_human
Tgene	PBX1	C4539968	CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT SYNDROME WITH OR WITHOUT HEARING LOSS, ABNORMAL EARS, OR DEVELOPMENTAL DELAY	1	GENOMICS_ENGLAND