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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TFAP2A-MAK

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TFAP2A-MAK
	FusionPDB ID: 90258
	FusionGDB2.0 ID: 90258
		Hgene	Tgene
	Gene symbol	TFAP2A	MAK
	Gene ID	7020	57538
	Gene name	transcription factor AP-2 alpha	alpha kinase 3
	Synonyms	AP-2\|AP-2alpha\|AP2TF\|BOFS\|TFAP2	CMH27\|MAK\|MIDORI
	Cytomap	6p24.3	15q25.3
	Type of gene	protein-coding	protein-coding
	Description	transcription factor AP-2-alphaAP-2 transcription factoractivating enhancer-binding protein 2-alphaactivator protein 2transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	alpha-protein kinase 3muscle alpha-kinasemuscle alpha-protein kinasemyocyte induction differentiation originator
	Modification date	20200328	20200313
	UniProtAcc	.	Q9BXY0
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000319516, ENST00000379604, ENST00000379608, ENST00000379613, ENST00000482890, ENST00000497266,	ENST00000538030, ENST00000536370, ENST00000313243, ENST00000354489, ENST00000474039,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 4 X 3=48	4 X 4 X 4=64
	# samples	4	4
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TFAP2A [Title/Abstract] AND MAK [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TFAP2A(10404741)-MAK(10764839), # samples:3
Anticipated loss of major functional domain due to fusion event.	TFAP2A-MAK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TFAP2A-MAK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TFAP2A-MAK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TFAP2A-MAK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TFAP2A-MAK seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TFAP2A-MAK seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. TFAP2A-MAK seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. TFAP2A-MAK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. TFAP2A-MAK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TFAP2A	GO:0000122	negative regulation of transcription by RNA polymerase II	8321221\|9520389\|20066163
Hgene	TFAP2A	GO:0008285	negative regulation of cell proliferation	20607706
Hgene	TFAP2A	GO:0030501	positive regulation of bone mineralization	19578371
Hgene	TFAP2A	GO:0043066	negative regulation of apoptotic process	20066163
Hgene	TFAP2A	GO:0043525	positive regulation of neuron apoptotic process	20607706
Hgene	TFAP2A	GO:0045595	regulation of cell differentiation	20607706
Hgene	TFAP2A	GO:0045892	negative regulation of transcription, DNA-templated	20607706
Hgene	TFAP2A	GO:0045893	positive regulation of transcription, DNA-templated	12586840
Hgene	TFAP2A	GO:0045944	positive regulation of transcription by RNA polymerase II	7555706\|7559606\|11278550\|20808827
Hgene	TFAP2A	GO:0070172	positive regulation of tooth mineralization	19578371
Hgene	TFAP2A	GO:0071281	cellular response to iron ion	20808827
Hgene	TFAP2A	GO:2000378	negative regulation of reactive oxygen species metabolic process	20066163

Fusion gene breakpoints across TFAP2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MAK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AN-A0AR-01A	TFAP2A	chr6	10404741	-	MAK	chr6	10764839	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000379613	TFAP2A	chr6	10404741	-	ENST00000313243	MAK	chr6	10764839	-	2911	1027	98	1081	327
ENST00000379613	TFAP2A	chr6	10404741	-	ENST00000474039	MAK	chr6	10764839	-	2911	1027	98	1081	327
ENST00000379604	TFAP2A	chr6	10404741	-	ENST00000313243	MAK	chr6	10764839	-	2900	1016	87	1070	327
ENST00000379604	TFAP2A	chr6	10404741	-	ENST00000474039	MAK	chr6	10764839	-	2900	1016	87	1070	327
ENST00000319516	TFAP2A	chr6	10404741	-	ENST00000313243	MAK	chr6	10764839	-	2824	940	101	994	297
ENST00000319516	TFAP2A	chr6	10404741	-	ENST00000474039	MAK	chr6	10764839	-	2824	940	101	994	297
ENST00000379608	TFAP2A	chr6	10404741	-	ENST00000313243	MAK	chr6	10764839	-	3408	1524	778	1578	266
ENST00000379608	TFAP2A	chr6	10404741	-	ENST00000474039	MAK	chr6	10764839	-	3408	1524	778	1578	266
ENST00000482890	TFAP2A	chr6	10404741	-	ENST00000313243	MAK	chr6	10764839	-	3001	1117	242	1171	309
ENST00000482890	TFAP2A	chr6	10404741	-	ENST00000474039	MAK	chr6	10764839	-	3001	1117	242	1171	309

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000379613	ENST00000313243	TFAP2A	chr6	10404741	-	MAK	chr6	10764839	-	0.009177532	0.99082243
ENST00000379613	ENST00000474039	TFAP2A	chr6	10404741	-	MAK	chr6	10764839	-	0.009177532	0.99082243
ENST00000379604	ENST00000313243	TFAP2A	chr6	10404741	-	MAK	chr6	10764839	-	0.00911806	0.9908819
ENST00000379604	ENST00000474039	TFAP2A	chr6	10404741	-	MAK	chr6	10764839	-	0.00911806	0.9908819
ENST00000319516	ENST00000313243	TFAP2A	chr6	10404741	-	MAK	chr6	10764839	-	0.01921344	0.9807866
ENST00000319516	ENST00000474039	TFAP2A	chr6	10404741	-	MAK	chr6	10764839	-	0.01921344	0.9807866
ENST00000379608	ENST00000313243	TFAP2A	chr6	10404741	-	MAK	chr6	10764839	-	0.023554634	0.9764454
ENST00000379608	ENST00000474039	TFAP2A	chr6	10404741	-	MAK	chr6	10764839	-	0.023554634	0.9764454
ENST00000482890	ENST00000313243	TFAP2A	chr6	10404741	-	MAK	chr6	10764839	-	0.005349606	0.9946504
ENST00000482890	ENST00000474039	TFAP2A	chr6	10404741	-	MAK	chr6	10764839	-	0.005349606	0.9946504

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>90258_90258_1_TFAP2A-MAK_TFAP2A_chr6_10404741_ENST00000319516_MAK_chr6_10764839_ENST00000313243_length(amino acids)=297AA_BP=279
MPKRFQGAGPTEPSSPCPAGTSRQERRAAMSILAKMGDWQDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPI
YPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPHA
IEEVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLN

--------------------------------------------------------------

>90258_90258_2_TFAP2A-MAK_TFAP2A_chr6_10404741_ENST00000319516_MAK_chr6_10764839_ENST00000474039_length(amino acids)=297AA_BP=279
MPKRFQGAGPTEPSSPCPAGTSRQERRAAMSILAKMGDWQDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPI
YPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPHA
IEEVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLN

--------------------------------------------------------------

>90258_90258_3_TFAP2A-MAK_TFAP2A_chr6_10404741_ENST00000379604_MAK_chr6_10764839_ENST00000313243_length(amino acids)=327AA_BP=309
MPSSSPSSFSSSTSSPSSSSSCAHRRQPALCAHPESSSTWVRDREGHIRSRRSMKMLWKLTDNIKYEDCEDRHDGTSNGTARLPQLGTVG
QSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRR
DYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVP

--------------------------------------------------------------

>90258_90258_4_TFAP2A-MAK_TFAP2A_chr6_10404741_ENST00000379604_MAK_chr6_10764839_ENST00000474039_length(amino acids)=327AA_BP=309
MPSSSPSSFSSSTSSPSSSSSCAHRRQPALCAHPESSSTWVRDREGHIRSRRSMKMLWKLTDNIKYEDCEDRHDGTSNGTARLPQLGTVG
QSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRR
DYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVP

--------------------------------------------------------------

>90258_90258_5_TFAP2A-MAK_TFAP2A_chr6_10404741_ENST00000379608_MAK_chr6_10764839_ENST00000313243_length(amino acids)=266AA_BP=248
MLVHSFSAMDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGW
PGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSKSN

--------------------------------------------------------------

>90258_90258_6_TFAP2A-MAK_TFAP2A_chr6_10404741_ENST00000379608_MAK_chr6_10764839_ENST00000474039_length(amino acids)=266AA_BP=248
MLVHSFSAMDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGW
PGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSKSN

--------------------------------------------------------------

>90258_90258_7_TFAP2A-MAK_TFAP2A_chr6_10404741_ENST00000379613_MAK_chr6_10764839_ENST00000313243_length(amino acids)=327AA_BP=309
MPSSSPSSFSSSTSSPSSSSSCAHRRQPALCAHPESSSTWVRDREGHIRSRRSMKMLWKLTDNIKYEDCEDRHDGTSNGTARLPQLGTVG
QSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRR
DYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVP

--------------------------------------------------------------

>90258_90258_8_TFAP2A-MAK_TFAP2A_chr6_10404741_ENST00000379613_MAK_chr6_10764839_ENST00000474039_length(amino acids)=327AA_BP=309
MPSSSPSSFSSSTSSPSSSSSCAHRRQPALCAHPESSSTWVRDREGHIRSRRSMKMLWKLTDNIKYEDCEDRHDGTSNGTARLPQLGTVG
QSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRR
DYRRHEDLLHGPHALSSGLGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVP

--------------------------------------------------------------

>90258_90258_9_TFAP2A-MAK_TFAP2A_chr6_10404741_ENST00000482890_MAK_chr6_10764839_ENST00000313243_length(amino acids)=309AA_BP=291
MELSSNLFRPALCAHPESSSTWVRDREGHIRSRRSMKMLWKLTDNIKYEDCEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADF
QPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALSSG
LGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAE

--------------------------------------------------------------

>90258_90258_10_TFAP2A-MAK_TFAP2A_chr6_10404741_ENST00000482890_MAK_chr6_10764839_ENST00000474039_length(amino acids)=309AA_BP=291
MELSSNLFRPALCAHPESSSTWVRDREGHIRSRRSMKMLWKLTDNIKYEDCEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADF
QPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALSSG
LGDLSIHSLPHAIEEVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:10404741/chr6:10764839)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MAK Q9BXY0
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TFAP2A

chr6:10404741

chr6:10764839

ENST00000319516

29_117

250.66666666666666

434.0

Compositional bias

Note=Gln/Pro-rich (transactivation domain)

Hgene

TFAP2A

chr6:10404741

chr6:10764839

ENST00000379604

29_117

254.66666666666666

438.0

Compositional bias

Note=Gln/Pro-rich (transactivation domain)

Hgene

TFAP2A

chr6:10404741

chr6:10764839

ENST00000379608

29_117

248.66666666666666

432.0

Compositional bias

Note=Gln/Pro-rich (transactivation domain)

Hgene

TFAP2A

chr6:10404741

chr6:10764839

ENST00000482890

29_117

254.66666666666666

438.0

Compositional bias

Note=Gln/Pro-rich (transactivation domain)

Hgene

TFAP2A

chr6:10404741

chr6:10764839

ENST00000319516

57_62

250.66666666666666

434.0

Motif

Note=PPxY motif

Hgene

TFAP2A

chr6:10404741

chr6:10764839

ENST00000379604

57_62

254.66666666666666

438.0

Motif

Note=PPxY motif

Hgene

TFAP2A

chr6:10404741

chr6:10764839

ENST00000379608

57_62

248.66666666666666

432.0

Motif

Note=PPxY motif

Hgene

TFAP2A

chr6:10404741

chr6:10764839

ENST00000482890

57_62

254.66666666666666

438.0

Motif

Note=PPxY motif

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TFAP2A

chr6:10404741

chr6:10764839

ENST00000319516

280_410

250.66666666666666

434.0

Region

Note=H-S-H (helix-span-helix)%2C dimerization

Hgene

TFAP2A

chr6:10404741

chr6:10764839

ENST00000379604

280_410

254.66666666666666

438.0

Region

Note=H-S-H (helix-span-helix)%2C dimerization

Hgene

TFAP2A

chr6:10404741

chr6:10764839

ENST00000379608

280_410

248.66666666666666

432.0

Region

Note=H-S-H (helix-span-helix)%2C dimerization

Hgene

TFAP2A

chr6:10404741

chr6:10764839

ENST00000482890

280_410

254.66666666666666

438.0

Region

Note=H-S-H (helix-span-helix)%2C dimerization

Tgene

MAK

chr6:10404741

chr6:10764839

ENST00000313243

309_368

572.3333333333334

624.0

Compositional bias

Note=Glu/Pro-rich

Tgene

MAK

chr6:10404741

chr6:10764839

ENST00000354489

309_368

572.3333333333334

624.0

Compositional bias

Note=Glu/Pro-rich

Tgene

MAK

chr6:10404741

chr6:10764839

ENST00000474039

309_368

572.3333333333334

624.0

Compositional bias

Note=Glu/Pro-rich

Tgene

MAK

chr6:10404741

chr6:10764839

ENST00000313243

4_284

572.3333333333334

624.0

Domain

Protein kinase

Tgene

MAK

chr6:10404741

chr6:10764839

ENST00000354489

4_284

572.3333333333334

624.0

Domain

Protein kinase

Tgene

MAK

chr6:10404741

chr6:10764839

ENST00000474039

4_284

572.3333333333334

624.0

Domain

Protein kinase

Tgene

MAK

chr6:10404741

chr6:10764839

ENST00000313243

10_18

572.3333333333334

624.0

Nucleotide binding

ATP

Tgene

MAK

chr6:10404741

chr6:10764839

ENST00000354489

10_18

572.3333333333334

624.0

Nucleotide binding

ATP

Tgene

MAK

chr6:10404741

chr6:10764839

ENST00000474039

10_18

572.3333333333334

624.0

Nucleotide binding

ATP

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TFAP2A
MAK

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to TFAP2A-MAK

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to TFAP2A-MAK

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source