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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:THRA-CDK12

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: THRA-CDK12
FusionPDB ID: 90696
FusionGDB2.0 ID: 90696
HgeneTgene
Gene symbol

THRA

CDK12

Gene ID

7067

51755

Gene namethyroid hormone receptor alphacyclin dependent kinase 12
SynonymsAR7|CHNG6|EAR7|ERB-T-1|ERBA|ERBA1|NR1A1|THRA1|THRA2|c-ERBA-1CRK7|CRKR|CRKRS
Cytomap

17q21.1

17q12

Type of geneprotein-codingprotein-coding
Descriptionthyroid hormone receptor alphaEAR-7ERBA-related 7V-erbA-related protein 7c-erbA-alphanuclear receptor subfamily 1 group A member 1thyroid hormone receptor alpha 1thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homocyclin-dependent kinase 12CDC2-related protein kinase 7Cdc2-related kinase, arginine/serine-richcell division cycle 2-related protein kinase 7cell division protein kinase 12
Modification date2020031320200313
UniProtAcc.

Q9NYV4

Ensembl transtripts involved in fusion geneENST idsENST00000264637, ENST00000394121, 
ENST00000450525, ENST00000546243, 
ENST00000584985, 		ENST00000430627, 
ENST00000447079, ENST00000559545, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 10 X 10=140036 X 30 X 14=15120
# samples 2355
** MAII scorelog2(23/1400*10)=-2.60572106088795
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(55/15120*10)=-4.78088271069641
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: THRA [Title/Abstract] AND CDK12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)THRA(38245586)-CDK12(37686884), # samples:3
Anticipated loss of major functional domain due to fusion event.THRA-CDK12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
THRA-CDK12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
THRA-CDK12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
THRA-CDK12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
THRA-CDK12 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
THRA-CDK12 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
THRA-CDK12 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
THRA-CDK12 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
THRA-CDK12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
THRA-CDK12 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
THRA-CDK12 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTHRA

GO:0006357

regulation of transcription by RNA polymerase II

18052923

HgeneTHRA

GO:0006366

transcription by RNA polymerase II

8710870|9653119

HgeneTHRA

GO:0009755

hormone-mediated signaling pathway

18052923

HgeneTHRA

GO:0017055

negative regulation of RNA polymerase II transcriptional preinitiation complex assembly

8524305

HgeneTHRA

GO:0045892

negative regulation of transcription, DNA-templated

8710870

HgeneTHRA

GO:2000143

negative regulation of DNA-templated transcription, initiation

8524305

TgeneCDK12

GO:0046777

protein autophosphorylation

11683387


check buttonFusion gene breakpoints across THRA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDK12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8289-01ATHRAchr17

38245586

+CDK12chr17

37686857

+
ChimerDB4STADTCGA-BR-8289-01ATHRAchr17

38245586

-CDK12chr17

37686884

+
ChimerDB4STADTCGA-BR-8289-01ATHRAchr17

38245586

+CDK12chr17

37686884

+
ChimerDB4STADTCGA-BR-8289THRAchr17

38245586

+CDK12chr17

37686883

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394121THRAchr1738245586+ENST00000430627CDK12chr1737686884+351316665561758400
ENST00000264637THRAchr1738245586+ENST00000430627CDK12chr1737686884+353716905801782400
ENST00000584985THRAchr1738245586+ENST00000430627CDK12chr1737686884+353716905801782400
ENST00000450525THRAchr1738245586+ENST00000430627CDK12chr1737686884+661447674911480329
ENST00000546243THRAchr1738245586+ENST00000447079CDK12chr1737686884+629617814021391329
ENST00000394121THRAchr1738245586+ENST00000430627CDK12chr1737686883+351316665561758400
ENST00000264637THRAchr1738245586+ENST00000430627CDK12chr1737686883+353716905801782400
ENST00000584985THRAchr1738245586+ENST00000430627CDK12chr1737686883+353716905801782400
ENST00000450525THRAchr1738245586+ENST00000430627CDK12chr1737686883+661447674911480329
ENST00000546243THRAchr1738245586+ENST00000447079CDK12chr1737686883+629717814021391329

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394121ENST00000430627THRAchr1738245586+CDK12chr1737686884+0.0068443740.99315566
ENST00000264637ENST00000430627THRAchr1738245586+CDK12chr1737686884+0.0096888010.99031115
ENST00000584985ENST00000430627THRAchr1738245586+CDK12chr1737686884+0.0096888010.99031115
ENST00000450525ENST00000430627THRAchr1738245586+CDK12chr1737686884+0.007241510.9927585
ENST00000546243ENST00000447079THRAchr1738245586+CDK12chr1737686884+0.0017894580.99821055
ENST00000394121ENST00000430627THRAchr1738245586+CDK12chr1737686883+0.0068443740.99315566
ENST00000264637ENST00000430627THRAchr1738245586+CDK12chr1737686883+0.0096888010.99031115
ENST00000584985ENST00000430627THRAchr1738245586+CDK12chr1737686883+0.0096888010.99031115
ENST00000450525ENST00000430627THRAchr1738245586+CDK12chr1737686883+0.007241510.9927585
ENST00000546243ENST00000447079THRAchr1738245586+CDK12chr1737686883+0.0018239540.9981761

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>90696_90696_1_THRA-CDK12_THRA_chr17_38245586_ENST00000264637_CDK12_chr17_37686883_ENST00000430627_length(amino acids)=400AA_BP=370
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS
CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE
SDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI

--------------------------------------------------------------

>90696_90696_2_THRA-CDK12_THRA_chr17_38245586_ENST00000264637_CDK12_chr17_37686884_ENST00000430627_length(amino acids)=400AA_BP=370
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS
CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE
SDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI

--------------------------------------------------------------

>90696_90696_3_THRA-CDK12_THRA_chr17_38245586_ENST00000394121_CDK12_chr17_37686883_ENST00000430627_length(amino acids)=400AA_BP=370
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS
CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE
SDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI

--------------------------------------------------------------

>90696_90696_4_THRA-CDK12_THRA_chr17_38245586_ENST00000394121_CDK12_chr17_37686884_ENST00000430627_length(amino acids)=400AA_BP=370
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS
CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE
SDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI

--------------------------------------------------------------

>90696_90696_5_THRA-CDK12_THRA_chr17_38245586_ENST00000450525_CDK12_chr17_37686883_ENST00000430627_length(amino acids)=329AA_BP=
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS
CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE

--------------------------------------------------------------

>90696_90696_6_THRA-CDK12_THRA_chr17_38245586_ENST00000450525_CDK12_chr17_37686884_ENST00000430627_length(amino acids)=329AA_BP=
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS
CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE

--------------------------------------------------------------

>90696_90696_7_THRA-CDK12_THRA_chr17_38245586_ENST00000546243_CDK12_chr17_37686883_ENST00000447079_length(amino acids)=329AA_BP=
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS
CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE

--------------------------------------------------------------

>90696_90696_8_THRA-CDK12_THRA_chr17_38245586_ENST00000546243_CDK12_chr17_37686884_ENST00000447079_length(amino acids)=329AA_BP=
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS
CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE

--------------------------------------------------------------

>90696_90696_9_THRA-CDK12_THRA_chr17_38245586_ENST00000584985_CDK12_chr17_37686883_ENST00000430627_length(amino acids)=400AA_BP=370
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS
CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE
SDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI

--------------------------------------------------------------

>90696_90696_10_THRA-CDK12_THRA_chr17_38245586_ENST00000584985_CDK12_chr17_37686884_ENST00000430627_length(amino acids)=400AA_BP=370
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYS
CKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPE
SDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38245586/chr17:37686884)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CDK12

Q9NYV4

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. {ECO:0000269|PubMed:11683387, ECO:0000269|PubMed:19651820, ECO:0000269|PubMed:20952539, ECO:0000269|PubMed:22012619, ECO:0000269|PubMed:24662513}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHRAchr17:38245586chr17:37686883ENST00000264637+91053_127370.0491.0DNA bindingNuclear receptor
HgeneTHRAchr17:38245586chr17:37686883ENST00000394121+91053_127370.0491.0DNA bindingNuclear receptor
HgeneTHRAchr17:38245586chr17:37686883ENST00000584985+91053_127370.0452.0DNA bindingNuclear receptor
HgeneTHRAchr17:38245586chr17:37686884ENST00000264637+91053_127370.0491.0DNA bindingNuclear receptor
HgeneTHRAchr17:38245586chr17:37686884ENST00000394121+91053_127370.0491.0DNA bindingNuclear receptor
HgeneTHRAchr17:38245586chr17:37686884ENST00000584985+91053_127370.0452.0DNA bindingNuclear receptor
HgeneTHRAchr17:38245586chr17:37686883ENST00000264637+9101_52370.0491.0RegionNote=Modulating
HgeneTHRAchr17:38245586chr17:37686883ENST00000394121+9101_52370.0491.0RegionNote=Modulating
HgeneTHRAchr17:38245586chr17:37686883ENST00000584985+9101_52370.0452.0RegionNote=Modulating
HgeneTHRAchr17:38245586chr17:37686884ENST00000264637+9101_52370.0491.0RegionNote=Modulating
HgeneTHRAchr17:38245586chr17:37686884ENST00000394121+9101_52370.0491.0RegionNote=Modulating
HgeneTHRAchr17:38245586chr17:37686884ENST00000584985+9101_52370.0452.0RegionNote=Modulating
HgeneTHRAchr17:38245586chr17:37686883ENST00000264637+91053_73370.0491.0Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686883ENST00000264637+91091_115370.0491.0Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686883ENST00000394121+91053_73370.0491.0Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686883ENST00000394121+91091_115370.0491.0Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686883ENST00000584985+91053_73370.0452.0Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686883ENST00000584985+91091_115370.0452.0Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686884ENST00000264637+91053_73370.0491.0Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686884ENST00000264637+91091_115370.0491.0Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686884ENST00000394121+91053_73370.0491.0Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686884ENST00000394121+91091_115370.0491.0Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686884ENST00000584985+91053_73370.0452.0Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686884ENST00000584985+91091_115370.0452.0Zinc fingerNR C4-type
TgeneCDK12chr17:38245586chr17:37686883ENST0000043062712141266_12801253.33333333333331482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38245586chr17:37686883ENST000004470790141266_128001491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38245586chr17:37686883ENST00000447079014407_41301491.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:38245586chr17:37686883ENST00000447079014535_54001491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38245586chr17:37686884ENST0000043062712141266_12801253.33333333333331482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38245586chr17:37686884ENST000004470790141266_128001491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38245586chr17:37686884ENST00000447079014407_41301491.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:38245586chr17:37686884ENST00000447079014535_54001491.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38245586chr17:37686883ENST00000447079014727_102001491.0DomainProtein kinase
TgeneCDK12chr17:38245586chr17:37686884ENST00000447079014727_102001491.0DomainProtein kinase
TgeneCDK12chr17:38245586chr17:37686883ENST00000447079014733_74101491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:38245586chr17:37686883ENST00000447079014814_81901491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:38245586chr17:37686884ENST00000447079014733_74101491.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:38245586chr17:37686884ENST00000447079014814_81901491.0Nucleotide bindingNote=ATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHRAchr17:38245586chr17:37686883ENST00000450525+1953_1270411.0DNA bindingNuclear receptor
HgeneTHRAchr17:38245586chr17:37686883ENST00000546243+1953_1270411.0DNA bindingNuclear receptor
HgeneTHRAchr17:38245586chr17:37686884ENST00000450525+1953_1270411.0DNA bindingNuclear receptor
HgeneTHRAchr17:38245586chr17:37686884ENST00000546243+1953_1270411.0DNA bindingNuclear receptor
HgeneTHRAchr17:38245586chr17:37686883ENST00000264637+910163_407370.0491.0DomainNR LBD
HgeneTHRAchr17:38245586chr17:37686883ENST00000394121+910163_407370.0491.0DomainNR LBD
HgeneTHRAchr17:38245586chr17:37686883ENST00000450525+19163_4070411.0DomainNR LBD
HgeneTHRAchr17:38245586chr17:37686883ENST00000546243+19163_4070411.0DomainNR LBD
HgeneTHRAchr17:38245586chr17:37686883ENST00000584985+910163_407370.0452.0DomainNR LBD
HgeneTHRAchr17:38245586chr17:37686884ENST00000264637+910163_407370.0491.0DomainNR LBD
HgeneTHRAchr17:38245586chr17:37686884ENST00000394121+910163_407370.0491.0DomainNR LBD
HgeneTHRAchr17:38245586chr17:37686884ENST00000450525+19163_4070411.0DomainNR LBD
HgeneTHRAchr17:38245586chr17:37686884ENST00000546243+19163_4070411.0DomainNR LBD
HgeneTHRAchr17:38245586chr17:37686884ENST00000584985+910163_407370.0452.0DomainNR LBD
HgeneTHRAchr17:38245586chr17:37686883ENST00000450525+191_520411.0RegionNote=Modulating
HgeneTHRAchr17:38245586chr17:37686883ENST00000546243+191_520411.0RegionNote=Modulating
HgeneTHRAchr17:38245586chr17:37686884ENST00000450525+191_520411.0RegionNote=Modulating
HgeneTHRAchr17:38245586chr17:37686884ENST00000546243+191_520411.0RegionNote=Modulating
HgeneTHRAchr17:38245586chr17:37686883ENST00000450525+1953_730411.0Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686883ENST00000450525+1991_1150411.0Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686883ENST00000546243+1953_730411.0Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686883ENST00000546243+1991_1150411.0Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686884ENST00000450525+1953_730411.0Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686884ENST00000450525+1991_1150411.0Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686884ENST00000546243+1953_730411.0Zinc fingerNR C4-type
HgeneTHRAchr17:38245586chr17:37686884ENST00000546243+1991_1150411.0Zinc fingerNR C4-type
TgeneCDK12chr17:38245586chr17:37686883ENST000004306271214407_4131253.33333333333331482.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:38245586chr17:37686883ENST000004306271214535_5401253.33333333333331482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38245586chr17:37686884ENST000004306271214407_4131253.33333333333331482.0Compositional biasNote=Poly-Ala
TgeneCDK12chr17:38245586chr17:37686884ENST000004306271214535_5401253.33333333333331482.0Compositional biasNote=Poly-Pro
TgeneCDK12chr17:38245586chr17:37686883ENST000004306271214727_10201253.33333333333331482.0DomainProtein kinase
TgeneCDK12chr17:38245586chr17:37686884ENST000004306271214727_10201253.33333333333331482.0DomainProtein kinase
TgeneCDK12chr17:38245586chr17:37686883ENST000004306271214733_7411253.33333333333331482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:38245586chr17:37686883ENST000004306271214814_8191253.33333333333331482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:38245586chr17:37686884ENST000004306271214733_7411253.33333333333331482.0Nucleotide bindingNote=ATP
TgeneCDK12chr17:38245586chr17:37686884ENST000004306271214814_8191253.33333333333331482.0Nucleotide bindingNote=ATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
THRA
CDK12


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to THRA-CDK12


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to THRA-CDK12


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource