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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TLE3-THAP10

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TLE3-THAP10
FusionPDB ID: 91123
FusionGDB2.0 ID: 91123
HgeneTgene
Gene symbol

TLE3

THAP10

Gene ID

7090

56906

Gene nameTLE family member 3, transcriptional corepressorTHAP domain containing 10
SynonymsESG|ESG3|GRG3|HsT18976-
Cytomap

15q23

15q23

Type of geneprotein-codingprotein-coding
Descriptiontransducin-like enhancer protein 3enhancer of split groucho 3enhancer of split groucho-like protein 3transducin like enhancer of split 3transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)transducin-like enhancer of split 3 short isoformTHAP domain-containing protein 10
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000539550, ENST00000317509, 
ENST00000440567, ENST00000442299, 
ENST00000451782, ENST00000557907, 
ENST00000557997, ENST00000558201, 
ENST00000558379, ENST00000558939, 
ENST00000559048, ENST00000559929, 
ENST00000560589, ENST00000560939, 
ENST00000559191, ENST00000559574, 
ENST00000249861, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 14 X 6=11765 X 1 X 5=25
# samples 167
** MAII scorelog2(16/1176*10)=-2.877744249949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/25*10)=1.48542682717024
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TLE3 [Title/Abstract] AND THAP10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TLE3(70386871)-THAP10(71175247), # samples:3
Anticipated loss of major functional domain due to fusion event.TLE3-THAP10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TLE3-THAP10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TLE3-THAP10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TLE3-THAP10 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
TLE3-THAP10 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TLE3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across THAP10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CN-4738-01ATLE3chr15

70386871

-THAP10chr15

71175247

-
ChimerDB4HNSCTCGA-CN-4738TLE3chr15

70386870

-THAP10chr15

71175247

-
ChimerDB4HNSCTCGA-CN-4738TLE3chr15

70386871

-THAP10chr15

71175247

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000558939TLE3chr1570386871-ENST00000249861THAP10chr1571175247-3069161211711956261
ENST00000442299TLE3chr1570386871-ENST00000249861THAP10chr1571175247-281013539121697261
ENST00000317509TLE3chr1570386871-ENST00000249861THAP10chr1571175247-279313368951680261
ENST00000560589TLE3chr1570386871-ENST00000249861THAP10chr1571175247-1875418331762143
ENST00000559929TLE3chr1570386871-ENST00000249861THAP10chr1571175247-174428753631192
ENST00000559048TLE3chr1570386871-ENST00000249861THAP10chr1571175247-2010553235897220
ENST00000560939TLE3chr1570386871-ENST00000249861THAP10chr1571175247-2107650332994220
ENST00000557997TLE3chr1570386871-ENST00000249861THAP10chr1571175247-278113248831668261
ENST00000558201TLE3chr1570386871-ENST00000249861THAP10chr1571175247-184338668730220
ENST00000440567TLE3chr1570386871-ENST00000249861THAP10chr1571175247-174328655630191
ENST00000558379TLE3chr1570386871-ENST00000249861THAP10chr1571175247-16912340578192
ENST00000557907TLE3chr1570386871-ENST00000249861THAP10chr1571175247-16912340578192
ENST00000451782TLE3chr1570386871-ENST00000249861THAP10chr1571175247-173728046624192
ENST00000558939TLE3chr1570386870-ENST00000249861THAP10chr1571175247-3069161211711956261
ENST00000442299TLE3chr1570386870-ENST00000249861THAP10chr1571175247-281013539121697261
ENST00000317509TLE3chr1570386870-ENST00000249861THAP10chr1571175247-279313368951680261
ENST00000560589TLE3chr1570386870-ENST00000249861THAP10chr1571175247-1875418331762143
ENST00000559929TLE3chr1570386870-ENST00000249861THAP10chr1571175247-174428753631192
ENST00000559048TLE3chr1570386870-ENST00000249861THAP10chr1571175247-2010553235897220
ENST00000560939TLE3chr1570386870-ENST00000249861THAP10chr1571175247-2107650332994220
ENST00000557997TLE3chr1570386870-ENST00000249861THAP10chr1571175247-278113248831668261
ENST00000558201TLE3chr1570386870-ENST00000249861THAP10chr1571175247-184338668730220
ENST00000440567TLE3chr1570386870-ENST00000249861THAP10chr1571175247-174328655630191
ENST00000558379TLE3chr1570386870-ENST00000249861THAP10chr1571175247-16912340578192
ENST00000557907TLE3chr1570386870-ENST00000249861THAP10chr1571175247-16912340578192
ENST00000451782TLE3chr1570386870-ENST00000249861THAP10chr1571175247-173728046624192

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000558939ENST00000249861TLE3chr1570386871-THAP10chr1571175247-0.0018830570.99811697
ENST00000442299ENST00000249861TLE3chr1570386871-THAP10chr1571175247-0.0028919580.99710804
ENST00000317509ENST00000249861TLE3chr1570386871-THAP10chr1571175247-0.0030057520.99699426
ENST00000560589ENST00000249861TLE3chr1570386871-THAP10chr1571175247-0.0165697190.98343027
ENST00000559929ENST00000249861TLE3chr1570386871-THAP10chr1571175247-0.0007959960.999204
ENST00000559048ENST00000249861TLE3chr1570386871-THAP10chr1571175247-0.0007777150.9992223
ENST00000560939ENST00000249861TLE3chr1570386871-THAP10chr1571175247-0.0010723480.99892765
ENST00000557997ENST00000249861TLE3chr1570386871-THAP10chr1571175247-0.003093690.99690634
ENST00000558201ENST00000249861TLE3chr1570386871-THAP10chr1571175247-0.0006247130.9993753
ENST00000440567ENST00000249861TLE3chr1570386871-THAP10chr1571175247-0.0010878090.9989122
ENST00000558379ENST00000249861TLE3chr1570386871-THAP10chr1571175247-0.0010141050.9989858
ENST00000557907ENST00000249861TLE3chr1570386871-THAP10chr1571175247-0.0010141050.9989858
ENST00000451782ENST00000249861TLE3chr1570386871-THAP10chr1571175247-0.0009553460.9990446
ENST00000558939ENST00000249861TLE3chr1570386870-THAP10chr1571175247-0.0018830570.99811697
ENST00000442299ENST00000249861TLE3chr1570386870-THAP10chr1571175247-0.0028919580.99710804
ENST00000317509ENST00000249861TLE3chr1570386870-THAP10chr1571175247-0.0030057520.99699426
ENST00000560589ENST00000249861TLE3chr1570386870-THAP10chr1571175247-0.0165697190.98343027
ENST00000559929ENST00000249861TLE3chr1570386870-THAP10chr1571175247-0.0007959960.999204
ENST00000559048ENST00000249861TLE3chr1570386870-THAP10chr1571175247-0.0007777150.9992223
ENST00000560939ENST00000249861TLE3chr1570386870-THAP10chr1571175247-0.0010723480.99892765
ENST00000557997ENST00000249861TLE3chr1570386870-THAP10chr1571175247-0.003093690.99690634
ENST00000558201ENST00000249861TLE3chr1570386870-THAP10chr1571175247-0.0006247130.9993753
ENST00000440567ENST00000249861TLE3chr1570386870-THAP10chr1571175247-0.0010878090.9989122
ENST00000558379ENST00000249861TLE3chr1570386870-THAP10chr1571175247-0.0010141050.9989858
ENST00000557907ENST00000249861TLE3chr1570386870-THAP10chr1571175247-0.0010141050.9989858
ENST00000451782ENST00000249861TLE3chr1570386870-THAP10chr1571175247-0.0009553460.9990446

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>91123_91123_1_TLE3-THAP10_TLE3_chr15_70386870_ENST00000317509_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=261AA_BP=147
MPPAPRLFVSTWGGRPTLGFRCENELGGPGASSRFPGRPPLGLGSPLPRTSPARALGASTLSESRPLPAMYPQGRHPAPHQPGQPGFKFT
VAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQPHADNPSNTVTSVPTHCEEGPV

--------------------------------------------------------------

>91123_91123_2_TLE3-THAP10_TLE3_chr15_70386870_ENST00000440567_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=191AA_BP=77
MLVATFMAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQPH
ADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWSRTSSLFDIYSSDSETDTDWDIKSEQSDLS

--------------------------------------------------------------

>91123_91123_3_TLE3-THAP10_TLE3_chr15_70386870_ENST00000442299_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=261AA_BP=147
MPPAPRLFVSTWGGRPTLGFRCENELGGPGASSRFPGRPPLGLGSPLPRTSPARALGASTLSESRPLPAMYPQGRHPAPHQPGQPGFKFT
VAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQPHADNPSNTVTSVPTHCEEGPV

--------------------------------------------------------------

>91123_91123_4_TLE3-THAP10_TLE3_chr15_70386870_ENST00000451782_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=192AA_BP=78
MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQP
HADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWSRTSSLFDIYSSDSETDTDWDIKSEQSDL

--------------------------------------------------------------

>91123_91123_5_TLE3-THAP10_TLE3_chr15_70386870_ENST00000557907_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=192AA_BP=78
MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQP
HADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWSRTSSLFDIYSSDSETDTDWDIKSEQSDL

--------------------------------------------------------------

>91123_91123_6_TLE3-THAP10_TLE3_chr15_70386870_ENST00000557997_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=261AA_BP=147
MPPAPRLFVSTWGGRPTLGFRCENELGGPGASSRFPGRPPLGLGSPLPRTSPARALGASTLSESRPLPAMYPQGRHPAPHQPGQPGFKFT
VAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQPHADNPSNTVTSVPTHCEEGPV

--------------------------------------------------------------

>91123_91123_7_TLE3-THAP10_TLE3_chr15_70386870_ENST00000558201_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=220AA_BP=106
MRVASFGWAPLGRGRGRSERGLMPPPPPLSCLRGLQAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYV
MYYEMSYGLNIEMHKQITCENELVQTQPHADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWS

--------------------------------------------------------------

>91123_91123_8_TLE3-THAP10_TLE3_chr15_70386870_ENST00000558379_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=192AA_BP=78
MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQP
HADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWSRTSSLFDIYSSDSETDTDWDIKSEQSDL

--------------------------------------------------------------

>91123_91123_9_TLE3-THAP10_TLE3_chr15_70386870_ENST00000558939_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=261AA_BP=147
MPPAPRLFVSTWGGRPTLGFRCENELGGPGASSRFPGRPPLGLGSPLPRTSPARALGASTLSESRPLPAMYPQGRHPAPHQPGQPGFKFT
VAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQPHADNPSNTVTSVPTHCEEGPV

--------------------------------------------------------------

>91123_91123_10_TLE3-THAP10_TLE3_chr15_70386870_ENST00000559048_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=220AA_BP=106
MRVASFGWAPLGRGRGRSERGLMPPPPPLSCLRGLQAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYV
MYYEMSYGLNIEMHKQITCENELVQTQPHADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWS

--------------------------------------------------------------

>91123_91123_11_TLE3-THAP10_TLE3_chr15_70386870_ENST00000559929_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=192AA_BP=78
MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQP
HADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWSRTSSLFDIYSSDSETDTDWDIKSEQSDL

--------------------------------------------------------------

>91123_91123_12_TLE3-THAP10_TLE3_chr15_70386870_ENST00000560589_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=143AA_BP=29
MANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQPHADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKR

--------------------------------------------------------------

>91123_91123_13_TLE3-THAP10_TLE3_chr15_70386870_ENST00000560939_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=220AA_BP=106
MRVASFGWAPLGRGRGRSERGLMPPPPPLSCLRGLQAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYV
MYYEMSYGLNIEMHKQITCENELVQTQPHADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWS

--------------------------------------------------------------

>91123_91123_14_TLE3-THAP10_TLE3_chr15_70386871_ENST00000317509_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=261AA_BP=147
MPPAPRLFVSTWGGRPTLGFRCENELGGPGASSRFPGRPPLGLGSPLPRTSPARALGASTLSESRPLPAMYPQGRHPAPHQPGQPGFKFT
VAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQPHADNPSNTVTSVPTHCEEGPV

--------------------------------------------------------------

>91123_91123_15_TLE3-THAP10_TLE3_chr15_70386871_ENST00000440567_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=191AA_BP=77
MLVATFMAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQPH
ADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWSRTSSLFDIYSSDSETDTDWDIKSEQSDLS

--------------------------------------------------------------

>91123_91123_16_TLE3-THAP10_TLE3_chr15_70386871_ENST00000442299_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=261AA_BP=147
MPPAPRLFVSTWGGRPTLGFRCENELGGPGASSRFPGRPPLGLGSPLPRTSPARALGASTLSESRPLPAMYPQGRHPAPHQPGQPGFKFT
VAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQPHADNPSNTVTSVPTHCEEGPV

--------------------------------------------------------------

>91123_91123_17_TLE3-THAP10_TLE3_chr15_70386871_ENST00000451782_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=192AA_BP=78
MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQP
HADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWSRTSSLFDIYSSDSETDTDWDIKSEQSDL

--------------------------------------------------------------

>91123_91123_18_TLE3-THAP10_TLE3_chr15_70386871_ENST00000557907_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=192AA_BP=78
MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQP
HADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWSRTSSLFDIYSSDSETDTDWDIKSEQSDL

--------------------------------------------------------------

>91123_91123_19_TLE3-THAP10_TLE3_chr15_70386871_ENST00000557997_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=261AA_BP=147
MPPAPRLFVSTWGGRPTLGFRCENELGGPGASSRFPGRPPLGLGSPLPRTSPARALGASTLSESRPLPAMYPQGRHPAPHQPGQPGFKFT
VAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQPHADNPSNTVTSVPTHCEEGPV

--------------------------------------------------------------

>91123_91123_20_TLE3-THAP10_TLE3_chr15_70386871_ENST00000558201_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=220AA_BP=106
MRVASFGWAPLGRGRGRSERGLMPPPPPLSCLRGLQAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYV
MYYEMSYGLNIEMHKQITCENELVQTQPHADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWS

--------------------------------------------------------------

>91123_91123_21_TLE3-THAP10_TLE3_chr15_70386871_ENST00000558379_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=192AA_BP=78
MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQP
HADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWSRTSSLFDIYSSDSETDTDWDIKSEQSDL

--------------------------------------------------------------

>91123_91123_22_TLE3-THAP10_TLE3_chr15_70386871_ENST00000558939_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=261AA_BP=147
MPPAPRLFVSTWGGRPTLGFRCENELGGPGASSRFPGRPPLGLGSPLPRTSPARALGASTLSESRPLPAMYPQGRHPAPHQPGQPGFKFT
VAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQPHADNPSNTVTSVPTHCEEGPV

--------------------------------------------------------------

>91123_91123_23_TLE3-THAP10_TLE3_chr15_70386871_ENST00000559048_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=220AA_BP=106
MRVASFGWAPLGRGRGRSERGLMPPPPPLSCLRGLQAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYV
MYYEMSYGLNIEMHKQITCENELVQTQPHADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWS

--------------------------------------------------------------

>91123_91123_24_TLE3-THAP10_TLE3_chr15_70386871_ENST00000559929_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=192AA_BP=78
MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQP
HADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWSRTSSLFDIYSSDSETDTDWDIKSEQSDL

--------------------------------------------------------------

>91123_91123_25_TLE3-THAP10_TLE3_chr15_70386871_ENST00000560589_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=143AA_BP=29
MANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQPHADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKR

--------------------------------------------------------------

>91123_91123_26_TLE3-THAP10_TLE3_chr15_70386871_ENST00000560939_THAP10_chr15_71175247_ENST00000249861_length(amino acids)=220AA_BP=106
MRVASFGWAPLGRGRGRSERGLMPPPPPLSCLRGLQAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYV
MYYEMSYGLNIEMHKQITCENELVQTQPHADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:70386871/chr15:71175247)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTLE3chr15:70386870chr15:71175247ENST00000317509-420225_22878.0761.0MotifNuclear localization signal
HgeneTLE3chr15:70386870chr15:71175247ENST00000451782-420225_22878.0770.0MotifNuclear localization signal
HgeneTLE3chr15:70386870chr15:71175247ENST00000557907-420225_22878.0765.0MotifNuclear localization signal
HgeneTLE3chr15:70386870chr15:71175247ENST00000557997-420225_22878.0765.0MotifNuclear localization signal
HgeneTLE3chr15:70386870chr15:71175247ENST00000558939-420225_22878.0773.0MotifNuclear localization signal
HgeneTLE3chr15:70386870chr15:71175247ENST00000559048-319225_22884.0773.0MotifNuclear localization signal
HgeneTLE3chr15:70386871chr15:71175247ENST00000317509-420225_22878.0761.0MotifNuclear localization signal
HgeneTLE3chr15:70386871chr15:71175247ENST00000451782-420225_22878.0770.0MotifNuclear localization signal
HgeneTLE3chr15:70386871chr15:71175247ENST00000557907-420225_22878.0765.0MotifNuclear localization signal
HgeneTLE3chr15:70386871chr15:71175247ENST00000557997-420225_22878.0765.0MotifNuclear localization signal
HgeneTLE3chr15:70386871chr15:71175247ENST00000558939-420225_22878.0773.0MotifNuclear localization signal
HgeneTLE3chr15:70386871chr15:71175247ENST00000559048-319225_22884.0773.0MotifNuclear localization signal
HgeneTLE3chr15:70386870chr15:71175247ENST00000317509-420132_19978.0761.0RegionGP domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000317509-4201_13178.0761.0RegionQ domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000317509-420200_26878.0761.0RegionCcN domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000317509-420269_45278.0761.0RegionSP domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000451782-420132_19978.0770.0RegionGP domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000451782-4201_13178.0770.0RegionQ domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000451782-420200_26878.0770.0RegionCcN domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000451782-420269_45278.0770.0RegionSP domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000557907-420132_19978.0765.0RegionGP domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000557907-4201_13178.0765.0RegionQ domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000557907-420200_26878.0765.0RegionCcN domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000557907-420269_45278.0765.0RegionSP domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000557997-420132_19978.0765.0RegionGP domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000557997-4201_13178.0765.0RegionQ domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000557997-420200_26878.0765.0RegionCcN domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000557997-420269_45278.0765.0RegionSP domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000558939-420132_19978.0773.0RegionGP domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000558939-4201_13178.0773.0RegionQ domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000558939-420200_26878.0773.0RegionCcN domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000558939-420269_45278.0773.0RegionSP domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000559048-319132_19984.0773.0RegionGP domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000559048-3191_13184.0773.0RegionQ domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000559048-319200_26884.0773.0RegionCcN domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000559048-319269_45284.0773.0RegionSP domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000317509-420132_19978.0761.0RegionGP domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000317509-4201_13178.0761.0RegionQ domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000317509-420200_26878.0761.0RegionCcN domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000317509-420269_45278.0761.0RegionSP domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000451782-420132_19978.0770.0RegionGP domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000451782-4201_13178.0770.0RegionQ domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000451782-420200_26878.0770.0RegionCcN domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000451782-420269_45278.0770.0RegionSP domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000557907-420132_19978.0765.0RegionGP domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000557907-4201_13178.0765.0RegionQ domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000557907-420200_26878.0765.0RegionCcN domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000557907-420269_45278.0765.0RegionSP domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000557997-420132_19978.0765.0RegionGP domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000557997-4201_13178.0765.0RegionQ domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000557997-420200_26878.0765.0RegionCcN domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000557997-420269_45278.0765.0RegionSP domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000558939-420132_19978.0773.0RegionGP domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000558939-4201_13178.0773.0RegionQ domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000558939-420200_26878.0773.0RegionCcN domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000558939-420269_45278.0773.0RegionSP domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000559048-319132_19984.0773.0RegionGP domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000559048-3191_13184.0773.0RegionQ domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000559048-319200_26884.0773.0RegionCcN domain
HgeneTLE3chr15:70386871chr15:71175247ENST00000559048-319269_45284.0773.0RegionSP domain
HgeneTLE3chr15:70386870chr15:71175247ENST00000317509-420484_52278.0761.0RepeatNote=WD 1
HgeneTLE3chr15:70386870chr15:71175247ENST00000317509-420530_56978.0761.0RepeatNote=WD 2
HgeneTLE3chr15:70386870chr15:71175247ENST00000317509-420574_61378.0761.0RepeatNote=WD 3
HgeneTLE3chr15:70386870chr15:71175247ENST00000317509-420616_65578.0761.0RepeatNote=WD 4
HgeneTLE3chr15:70386870chr15:71175247ENST00000317509-420657_69678.0761.0RepeatNote=WD 5
HgeneTLE3chr15:70386870chr15:71175247ENST00000317509-420698_73778.0761.0RepeatNote=WD 6
HgeneTLE3chr15:70386870chr15:71175247ENST00000317509-420739_77178.0761.0RepeatNote=WD 7
HgeneTLE3chr15:70386870chr15:71175247ENST00000451782-420484_52278.0770.0RepeatNote=WD 1
HgeneTLE3chr15:70386870chr15:71175247ENST00000451782-420530_56978.0770.0RepeatNote=WD 2
HgeneTLE3chr15:70386870chr15:71175247ENST00000451782-420574_61378.0770.0RepeatNote=WD 3
HgeneTLE3chr15:70386870chr15:71175247ENST00000451782-420616_65578.0770.0RepeatNote=WD 4
HgeneTLE3chr15:70386870chr15:71175247ENST00000451782-420657_69678.0770.0RepeatNote=WD 5
HgeneTLE3chr15:70386870chr15:71175247ENST00000451782-420698_73778.0770.0RepeatNote=WD 6
HgeneTLE3chr15:70386870chr15:71175247ENST00000451782-420739_77178.0770.0RepeatNote=WD 7
HgeneTLE3chr15:70386870chr15:71175247ENST00000557907-420484_52278.0765.0RepeatNote=WD 1
HgeneTLE3chr15:70386870chr15:71175247ENST00000557907-420530_56978.0765.0RepeatNote=WD 2
HgeneTLE3chr15:70386870chr15:71175247ENST00000557907-420574_61378.0765.0RepeatNote=WD 3
HgeneTLE3chr15:70386870chr15:71175247ENST00000557907-420616_65578.0765.0RepeatNote=WD 4
HgeneTLE3chr15:70386870chr15:71175247ENST00000557907-420657_69678.0765.0RepeatNote=WD 5
HgeneTLE3chr15:70386870chr15:71175247ENST00000557907-420698_73778.0765.0RepeatNote=WD 6
HgeneTLE3chr15:70386870chr15:71175247ENST00000557907-420739_77178.0765.0RepeatNote=WD 7
HgeneTLE3chr15:70386870chr15:71175247ENST00000557997-420484_52278.0765.0RepeatNote=WD 1
HgeneTLE3chr15:70386870chr15:71175247ENST00000557997-420530_56978.0765.0RepeatNote=WD 2
HgeneTLE3chr15:70386870chr15:71175247ENST00000557997-420574_61378.0765.0RepeatNote=WD 3
HgeneTLE3chr15:70386870chr15:71175247ENST00000557997-420616_65578.0765.0RepeatNote=WD 4
HgeneTLE3chr15:70386870chr15:71175247ENST00000557997-420657_69678.0765.0RepeatNote=WD 5
HgeneTLE3chr15:70386870chr15:71175247ENST00000557997-420698_73778.0765.0RepeatNote=WD 6
HgeneTLE3chr15:70386870chr15:71175247ENST00000557997-420739_77178.0765.0RepeatNote=WD 7
HgeneTLE3chr15:70386870chr15:71175247ENST00000558939-420484_52278.0773.0RepeatNote=WD 1
HgeneTLE3chr15:70386870chr15:71175247ENST00000558939-420530_56978.0773.0RepeatNote=WD 2
HgeneTLE3chr15:70386870chr15:71175247ENST00000558939-420574_61378.0773.0RepeatNote=WD 3
HgeneTLE3chr15:70386870chr15:71175247ENST00000558939-420616_65578.0773.0RepeatNote=WD 4
HgeneTLE3chr15:70386870chr15:71175247ENST00000558939-420657_69678.0773.0RepeatNote=WD 5
HgeneTLE3chr15:70386870chr15:71175247ENST00000558939-420698_73778.0773.0RepeatNote=WD 6
HgeneTLE3chr15:70386870chr15:71175247ENST00000558939-420739_77178.0773.0RepeatNote=WD 7
HgeneTLE3chr15:70386870chr15:71175247ENST00000559048-319484_52284.0773.0RepeatNote=WD 1
HgeneTLE3chr15:70386870chr15:71175247ENST00000559048-319530_56984.0773.0RepeatNote=WD 2
HgeneTLE3chr15:70386870chr15:71175247ENST00000559048-319574_61384.0773.0RepeatNote=WD 3
HgeneTLE3chr15:70386870chr15:71175247ENST00000559048-319616_65584.0773.0RepeatNote=WD 4
HgeneTLE3chr15:70386870chr15:71175247ENST00000559048-319657_69684.0773.0RepeatNote=WD 5
HgeneTLE3chr15:70386870chr15:71175247ENST00000559048-319698_73784.0773.0RepeatNote=WD 6
HgeneTLE3chr15:70386870chr15:71175247ENST00000559048-319739_77184.0773.0RepeatNote=WD 7
HgeneTLE3chr15:70386871chr15:71175247ENST00000317509-420484_52278.0761.0RepeatNote=WD 1
HgeneTLE3chr15:70386871chr15:71175247ENST00000317509-420530_56978.0761.0RepeatNote=WD 2
HgeneTLE3chr15:70386871chr15:71175247ENST00000317509-420574_61378.0761.0RepeatNote=WD 3
HgeneTLE3chr15:70386871chr15:71175247ENST00000317509-420616_65578.0761.0RepeatNote=WD 4
HgeneTLE3chr15:70386871chr15:71175247ENST00000317509-420657_69678.0761.0RepeatNote=WD 5
HgeneTLE3chr15:70386871chr15:71175247ENST00000317509-420698_73778.0761.0RepeatNote=WD 6
HgeneTLE3chr15:70386871chr15:71175247ENST00000317509-420739_77178.0761.0RepeatNote=WD 7
HgeneTLE3chr15:70386871chr15:71175247ENST00000451782-420484_52278.0770.0RepeatNote=WD 1
HgeneTLE3chr15:70386871chr15:71175247ENST00000451782-420530_56978.0770.0RepeatNote=WD 2
HgeneTLE3chr15:70386871chr15:71175247ENST00000451782-420574_61378.0770.0RepeatNote=WD 3
HgeneTLE3chr15:70386871chr15:71175247ENST00000451782-420616_65578.0770.0RepeatNote=WD 4
HgeneTLE3chr15:70386871chr15:71175247ENST00000451782-420657_69678.0770.0RepeatNote=WD 5
HgeneTLE3chr15:70386871chr15:71175247ENST00000451782-420698_73778.0770.0RepeatNote=WD 6
HgeneTLE3chr15:70386871chr15:71175247ENST00000451782-420739_77178.0770.0RepeatNote=WD 7
HgeneTLE3chr15:70386871chr15:71175247ENST00000557907-420484_52278.0765.0RepeatNote=WD 1
HgeneTLE3chr15:70386871chr15:71175247ENST00000557907-420530_56978.0765.0RepeatNote=WD 2
HgeneTLE3chr15:70386871chr15:71175247ENST00000557907-420574_61378.0765.0RepeatNote=WD 3
HgeneTLE3chr15:70386871chr15:71175247ENST00000557907-420616_65578.0765.0RepeatNote=WD 4
HgeneTLE3chr15:70386871chr15:71175247ENST00000557907-420657_69678.0765.0RepeatNote=WD 5
HgeneTLE3chr15:70386871chr15:71175247ENST00000557907-420698_73778.0765.0RepeatNote=WD 6
HgeneTLE3chr15:70386871chr15:71175247ENST00000557907-420739_77178.0765.0RepeatNote=WD 7
HgeneTLE3chr15:70386871chr15:71175247ENST00000557997-420484_52278.0765.0RepeatNote=WD 1
HgeneTLE3chr15:70386871chr15:71175247ENST00000557997-420530_56978.0765.0RepeatNote=WD 2
HgeneTLE3chr15:70386871chr15:71175247ENST00000557997-420574_61378.0765.0RepeatNote=WD 3
HgeneTLE3chr15:70386871chr15:71175247ENST00000557997-420616_65578.0765.0RepeatNote=WD 4
HgeneTLE3chr15:70386871chr15:71175247ENST00000557997-420657_69678.0765.0RepeatNote=WD 5
HgeneTLE3chr15:70386871chr15:71175247ENST00000557997-420698_73778.0765.0RepeatNote=WD 6
HgeneTLE3chr15:70386871chr15:71175247ENST00000557997-420739_77178.0765.0RepeatNote=WD 7
HgeneTLE3chr15:70386871chr15:71175247ENST00000558939-420484_52278.0773.0RepeatNote=WD 1
HgeneTLE3chr15:70386871chr15:71175247ENST00000558939-420530_56978.0773.0RepeatNote=WD 2
HgeneTLE3chr15:70386871chr15:71175247ENST00000558939-420574_61378.0773.0RepeatNote=WD 3
HgeneTLE3chr15:70386871chr15:71175247ENST00000558939-420616_65578.0773.0RepeatNote=WD 4
HgeneTLE3chr15:70386871chr15:71175247ENST00000558939-420657_69678.0773.0RepeatNote=WD 5
HgeneTLE3chr15:70386871chr15:71175247ENST00000558939-420698_73778.0773.0RepeatNote=WD 6
HgeneTLE3chr15:70386871chr15:71175247ENST00000558939-420739_77178.0773.0RepeatNote=WD 7
HgeneTLE3chr15:70386871chr15:71175247ENST00000559048-319484_52284.0773.0RepeatNote=WD 1
HgeneTLE3chr15:70386871chr15:71175247ENST00000559048-319530_56984.0773.0RepeatNote=WD 2
HgeneTLE3chr15:70386871chr15:71175247ENST00000559048-319574_61384.0773.0RepeatNote=WD 3
HgeneTLE3chr15:70386871chr15:71175247ENST00000559048-319616_65584.0773.0RepeatNote=WD 4
HgeneTLE3chr15:70386871chr15:71175247ENST00000559048-319657_69684.0773.0RepeatNote=WD 5
HgeneTLE3chr15:70386871chr15:71175247ENST00000559048-319698_73784.0773.0RepeatNote=WD 6
HgeneTLE3chr15:70386871chr15:71175247ENST00000559048-319739_77184.0773.0RepeatNote=WD 7
TgeneTHAP10chr15:70386870chr15:71175247ENST00000249861031_90143.0258.0Zinc fingerTHAP-type
TgeneTHAP10chr15:70386871chr15:71175247ENST00000249861031_90143.0258.0Zinc fingerTHAP-type


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>445_TLE3_70386871_THAP10_71175247_ranked_0.pdbTLE37038687070386871ENST00000249861THAP10chr1571175247-
MPPAPRLFVSTWGGRPTLGFRCENELGGPGASSRFPGRPPLGLGSPLPRTSPARALGASTLSESRPLPAMYPQGRHPAPHQPGQPGFKFT
VAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQITCENELVQTQPHADNPSNTVTSVPTHCEEGPV
261


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TLE3_pLDDT.png
all structure
all structure
THAP10_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TLE3
THAP10


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TLE3-THAP10


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TLE3-THAP10


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource