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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TLK2-IRAK3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TLK2-IRAK3
FusionPDB ID: 91156
FusionGDB2.0 ID: 91156
HgeneTgene
Gene symbol

TLK2

IRAK3

Gene ID

11011

11213

Gene nametousled like kinase 2interleukin 1 receptor associated kinase 3
SynonymsHsHPK|MRD57|PKU-ALPHAASRT5|IRAKM
Cytomap

17q23.2

12q14.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase tousled-like 2interleukin-1 receptor-associated kinase 3IL-1 receptor-associated kinase M
Modification date2020031320200313
UniProtAcc.

Q9Y616

Ensembl transtripts involved in fusion geneENST idsENST00000326270, ENST00000343388, 
ENST00000346027, ENST00000542523, 
ENST00000582809, ENST00000577616, 
ENST00000457197, ENST00000545837, 
ENST00000261233, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 11 X 9=17824 X 4 X 4=64
# samples 245
** MAII scorelog2(24/1782*10)=-2.8923910259134
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TLK2 [Title/Abstract] AND IRAK3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TLK2(60679541)-IRAK3(66620503), # samples:2
Anticipated loss of major functional domain due to fusion event.TLK2-IRAK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TLK2-IRAK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TLK2-IRAK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TLK2-IRAK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTLK2

GO:0001672

regulation of chromatin assembly or disassembly

12660173

HgeneTLK2

GO:0006468

protein phosphorylation

12660173

HgeneTLK2

GO:0006974

cellular response to DNA damage stimulus

12660173

HgeneTLK2

GO:0018105

peptidyl-serine phosphorylation

20016786

HgeneTLK2

GO:0035556

intracellular signal transduction

12660173

HgeneTLK2

GO:0071480

cellular response to gamma radiation

12660173

TgeneIRAK3

GO:0006468

protein phosphorylation

10383454


check buttonFusion gene breakpoints across TLK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IRAK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FD-A6TG-01ATLK2chr17

60679541

+IRAK3chr12

66620503

+
ChimerDB4BLCATCGA-FD-A6TGTLK2chr17

60679541

+IRAK3chr12

66620502

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000582809TLK2chr1760679541+ENST00000261233IRAK3chr1266620503+970421153703252960
ENST00000326270TLK2chr1760679541+ENST00000261233IRAK3chr1266620503+9782219312133301069
ENST00000346027TLK2chr1760679541+ENST00000261233IRAK3chr1266620503+9719213012132671048
ENST00000343388TLK2chr1760679541+ENST00000261233IRAK3chr1266620503+94981909503046998
ENST00000542523TLK2chr1760679541+ENST00000261233IRAK3chr1266620503+93771788252925966
ENST00000582809TLK2chr1760679541+ENST00000261233IRAK3chr1266620502+970421153703252960
ENST00000326270TLK2chr1760679541+ENST00000261233IRAK3chr1266620502+9782219312133301069
ENST00000346027TLK2chr1760679541+ENST00000261233IRAK3chr1266620502+9719213012132671048
ENST00000343388TLK2chr1760679541+ENST00000261233IRAK3chr1266620502+94981909503046998
ENST00000542523TLK2chr1760679541+ENST00000261233IRAK3chr1266620502+93771788252925966

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000582809ENST00000261233TLK2chr1760679541+IRAK3chr1266620503+0.0003396190.9996604
ENST00000326270ENST00000261233TLK2chr1760679541+IRAK3chr1266620503+0.0001659410.99983406
ENST00000346027ENST00000261233TLK2chr1760679541+IRAK3chr1266620503+6.12E-050.9999387
ENST00000343388ENST00000261233TLK2chr1760679541+IRAK3chr1266620503+7.32E-050.9999268
ENST00000542523ENST00000261233TLK2chr1760679541+IRAK3chr1266620503+7.30E-050.99992704
ENST00000582809ENST00000261233TLK2chr1760679541+IRAK3chr1266620502+0.0003396190.9996604
ENST00000326270ENST00000261233TLK2chr1760679541+IRAK3chr1266620502+0.0001659410.99983406
ENST00000346027ENST00000261233TLK2chr1760679541+IRAK3chr1266620502+6.12E-050.9999387
ENST00000343388ENST00000261233TLK2chr1760679541+IRAK3chr1266620502+7.32E-050.9999268
ENST00000542523ENST00000261233TLK2chr1760679541+IRAK3chr1266620502+7.30E-050.99992704

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>91156_91156_1_TLK2-IRAK3_TLK2_chr17_60679541_ENST00000326270_IRAK3_chr12_66620502_ENST00000261233_length(amino acids)=1069AA_BP=691
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCS
VGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL
DGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALE
NSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQ
WTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAE
YHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVK
IHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL
NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWFHHPNILELAAYFTETEKFCLIYPYMRNG
TLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKH
LWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAA
TRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFL

--------------------------------------------------------------

>91156_91156_2_TLK2-IRAK3_TLK2_chr17_60679541_ENST00000326270_IRAK3_chr12_66620503_ENST00000261233_length(amino acids)=1069AA_BP=691
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCS
VGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGL
DGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALE
NSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQ
WTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAE
YHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVK
IHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL
NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWFHHPNILELAAYFTETEKFCLIYPYMRNG
TLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKH
LWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAA
TRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFL

--------------------------------------------------------------

>91156_91156_3_TLK2-IRAK3_TLK2_chr17_60679541_ENST00000343388_IRAK3_chr12_66620502_ENST00000261233_length(amino acids)=998AA_BP=620
MPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQN
DQRNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ
NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMS
KKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ
KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGG
FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM
SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWFHHPNILELA
AYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFR
SHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVP
PCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRI
DRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWD

--------------------------------------------------------------

>91156_91156_4_TLK2-IRAK3_TLK2_chr17_60679541_ENST00000343388_IRAK3_chr12_66620503_ENST00000261233_length(amino acids)=998AA_BP=620
MPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQN
DQRNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQ
NSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMS
KKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQ
KQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGG
FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM
SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWFHHPNILELA
AYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFR
SHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVP
PCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRI
DRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWD

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>91156_91156_5_TLK2-IRAK3_TLK2_chr17_60679541_ENST00000346027_IRAK3_chr12_66620502_ENST00000261233_length(amino acids)=1048AA_BP=670
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLC
SVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYG
LDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISAL
ENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTE
QWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAE
IQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHAC
REYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVN
GTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRI
GILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVY
SFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQA
SLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSS

--------------------------------------------------------------

>91156_91156_6_TLK2-IRAK3_TLK2_chr17_60679541_ENST00000346027_IRAK3_chr12_66620503_ENST00000261233_length(amino acids)=1048AA_BP=670
MPGRGVAALRRGPGSAPGLPRGRAERSAAGSGRGPSREERGAAAAAAAAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLC
SVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYG
LDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISAL
ENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTE
QWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAE
IQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHAC
REYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVN
GTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRI
GILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVY
SFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQA
SLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSS

--------------------------------------------------------------

>91156_91156_7_TLK2-IRAK3_TLK2_chr17_60679541_ENST00000542523_IRAK3_chr12_66620502_ENST00000261233_length(amino acids)=966AA_BP=588
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFER
RVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDL
TIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTV
RHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLG
HLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKK
ENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLK
PGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTA
PLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGK
LSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVL
NTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEE

--------------------------------------------------------------

>91156_91156_8_TLK2-IRAK3_TLK2_chr17_60679541_ENST00000542523_IRAK3_chr12_66620503_ENST00000261233_length(amino acids)=966AA_BP=588
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFER
RVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDL
TIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTV
RHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLG
HLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKK
ENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLK
PGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTA
PLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGK
LSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVL
NTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEE

--------------------------------------------------------------

>91156_91156_9_TLK2-IRAK3_TLK2_chr17_60679541_ENST00000582809_IRAK3_chr12_66620502_ENST00000261233_length(amino acids)=960AA_BP=582
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKIS
ALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASF
TEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEE
AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKH
ACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL
VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHI
RIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTD
VYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLEST
QASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPS

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>91156_91156_10_TLK2-IRAK3_TLK2_chr17_60679541_ENST00000582809_IRAK3_chr12_66620503_ENST00000261233_length(amino acids)=960AA_BP=582
MCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPL
YGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKIS
ALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASF
TEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEE
AEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKH
ACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILL
VNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHI
RIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTD
VYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLEST
QASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPS

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:60679541/chr12:66620503)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IRAK3

Q9Y616

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. {ECO:0000250|UniProtKB:Q8K4B2, ECO:0000269|PubMed:10383454}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTLK2chr17:60679541chr12:66620502ENST00000326270+2023225_276641.6666666666666773.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620502ENST00000326270+2023317_347641.6666666666666773.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620502ENST00000326270+2023403_451641.6666666666666773.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620502ENST00000343388+1821225_276587.6666666666666719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620502ENST00000343388+1821317_347587.6666666666666719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620502ENST00000343388+1821403_451587.6666666666666719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620502ENST00000346027+1922225_276619.6666666666666751.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620502ENST00000346027+1922317_347619.6666666666666751.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620502ENST00000346027+1922403_451619.6666666666666751.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620502ENST00000542523+1821225_276587.6666666666666719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620502ENST00000542523+1821317_347587.6666666666666719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620502ENST00000542523+1821403_451587.6666666666666719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620503ENST00000326270+2023225_276641.6666666666666773.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620503ENST00000326270+2023317_347641.6666666666666773.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620503ENST00000326270+2023403_451641.6666666666666773.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620503ENST00000343388+1821225_276587.6666666666666719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620503ENST00000343388+1821317_347587.6666666666666719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620503ENST00000343388+1821403_451587.6666666666666719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620503ENST00000346027+1922225_276619.6666666666666751.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620503ENST00000346027+1922317_347619.6666666666666751.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620503ENST00000346027+1922403_451619.6666666666666751.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620503ENST00000542523+1821225_276587.6666666666666719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620503ENST00000542523+1821317_347587.6666666666666719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620503ENST00000542523+1821403_451587.6666666666666719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK2chr17:60679541chr12:66620502ENST00000326270+2023468_476641.6666666666666773.0Nucleotide bindingATP
HgeneTLK2chr17:60679541chr12:66620502ENST00000343388+1821468_476587.6666666666666719.0Nucleotide bindingATP
HgeneTLK2chr17:60679541chr12:66620502ENST00000346027+1922468_476619.6666666666666751.0Nucleotide bindingATP
HgeneTLK2chr17:60679541chr12:66620502ENST00000542523+1821468_476587.6666666666666719.0Nucleotide bindingATP
HgeneTLK2chr17:60679541chr12:66620503ENST00000326270+2023468_476641.6666666666666773.0Nucleotide bindingATP
HgeneTLK2chr17:60679541chr12:66620503ENST00000343388+1821468_476587.6666666666666719.0Nucleotide bindingATP
HgeneTLK2chr17:60679541chr12:66620503ENST00000346027+1922468_476619.6666666666666751.0Nucleotide bindingATP
HgeneTLK2chr17:60679541chr12:66620503ENST00000542523+1821468_476587.6666666666666719.0Nucleotide bindingATP
TgeneIRAK3chr17:60679541chr12:66620502ENST00000457197411165_452156.66666666666666536.0DomainProtein kinase
TgeneIRAK3chr17:60679541chr12:66620503ENST00000457197411165_452156.66666666666666536.0DomainProtein kinase
TgeneIRAK3chr17:60679541chr12:66620502ENST00000261233512295_298217.66666666666666597.0Nucleotide bindingATP
TgeneIRAK3chr17:60679541chr12:66620502ENST00000457197411171_179156.66666666666666536.0Nucleotide bindingATP
TgeneIRAK3chr17:60679541chr12:66620502ENST00000457197411295_298156.66666666666666536.0Nucleotide bindingATP
TgeneIRAK3chr17:60679541chr12:66620503ENST00000261233512295_298217.66666666666666597.0Nucleotide bindingATP
TgeneIRAK3chr17:60679541chr12:66620503ENST00000457197411171_179156.66666666666666536.0Nucleotide bindingATP
TgeneIRAK3chr17:60679541chr12:66620503ENST00000457197411295_298156.66666666666666536.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTLK2chr17:60679541chr12:66620502ENST00000326270+2023462_741641.6666666666666773.0DomainProtein kinase
HgeneTLK2chr17:60679541chr12:66620502ENST00000343388+1821462_741587.6666666666666719.0DomainProtein kinase
HgeneTLK2chr17:60679541chr12:66620502ENST00000346027+1922462_741619.6666666666666751.0DomainProtein kinase
HgeneTLK2chr17:60679541chr12:66620502ENST00000542523+1821462_741587.6666666666666719.0DomainProtein kinase
HgeneTLK2chr17:60679541chr12:66620503ENST00000326270+2023462_741641.6666666666666773.0DomainProtein kinase
HgeneTLK2chr17:60679541chr12:66620503ENST00000343388+1821462_741587.6666666666666719.0DomainProtein kinase
HgeneTLK2chr17:60679541chr12:66620503ENST00000346027+1922462_741619.6666666666666751.0DomainProtein kinase
HgeneTLK2chr17:60679541chr12:66620503ENST00000542523+1821462_741587.6666666666666719.0DomainProtein kinase
TgeneIRAK3chr17:60679541chr12:66620502ENST00000261233512165_452217.66666666666666597.0DomainProtein kinase
TgeneIRAK3chr17:60679541chr12:66620502ENST0000026123351241_106217.66666666666666597.0DomainDeath
TgeneIRAK3chr17:60679541chr12:66620502ENST0000045719741141_106156.66666666666666536.0DomainDeath
TgeneIRAK3chr17:60679541chr12:66620503ENST00000261233512165_452217.66666666666666597.0DomainProtein kinase
TgeneIRAK3chr17:60679541chr12:66620503ENST0000026123351241_106217.66666666666666597.0DomainDeath
TgeneIRAK3chr17:60679541chr12:66620503ENST0000045719741141_106156.66666666666666536.0DomainDeath
TgeneIRAK3chr17:60679541chr12:66620502ENST00000261233512171_179217.66666666666666597.0Nucleotide bindingATP
TgeneIRAK3chr17:60679541chr12:66620503ENST00000261233512171_179217.66666666666666597.0Nucleotide bindingATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TLK2
IRAK3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TLK2-IRAK3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TLK2-IRAK3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource