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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TM9SF4-HM13

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TM9SF4-HM13
FusionPDB ID: 91273
FusionGDB2.0 ID: 91273
HgeneTgene
Gene symbol

TM9SF4

HM13

Gene ID

9777

81502

Gene nametransmembrane 9 superfamily member 4histocompatibility minor 13
SynonymsdJ836N17.2H13|IMP1|IMPAS|IMPAS-1|MSTP086|PSENL3|PSL3|SPP|SPPL1
Cytomap

20q11.21

20q11.21

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane 9 superfamily member 4dinucleotide oxidase disulfide thiol exchanger 3 superfamily member 4transmembrane 9 superfamily protein member 4tumor cannibalism associated protein 1minor histocompatibility antigen H13intramembrane protease 1minor histocompatibility antigen 13presenilin-like protein 3signal peptide peptidase betasignal peptide peptidase like 1
Modification date2020031320200313
UniProtAcc.

Q8TCT9

Ensembl transtripts involved in fusion geneENST idsENST00000217315, ENST00000398022, 
ENST00000492709, ENST00000335574, 
ENST00000340852, ENST00000376127, 
ENST00000398174, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 19 X 14=532016 X 19 X 12=3648
# samples 2825
** MAII scorelog2(28/5320*10)=-4.24792751344359
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/3648*10)=-3.86710572950266
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TM9SF4 [Title/Abstract] AND HM13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TM9SF4(30747914)-HM13(30154013), # samples:3
Anticipated loss of major functional domain due to fusion event.TM9SF4-HM13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TM9SF4-HM13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TM9SF4-HM13 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TM9SF4-HM13 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTM9SF4

GO:0001666

response to hypoxia

25961573

TgeneHM13

GO:0033619

membrane protein proteolysis

14741365


check buttonFusion gene breakpoints across TM9SF4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HM13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0238-01ATM9SF4chr20

30697558

-HM13chr20

30136832

+
ChimerDB4GBMTCGA-06-0238-01ATM9SF4chr20

30697558

+HM13chr20

30136832

+
ChimerDB4GBMTCGA-06-0238-01ATM9SF4chr20

30697558

+HM13chr20

30137867

+
ChimerDB4GBMTCGA-06-0238TM9SF4chr20

30697558

+HM13chr20

30136831

+
ChimerDB4LUSCTCGA-66-2789-01ATM9SF4chr20

30747914

-HM13chr20

30154013

+
ChimerDB4LUSCTCGA-66-2789-01ATM9SF4chr20

30747914

+HM13chr20

30154013

+
ChimerDB4LUSCTCGA-66-2789TM9SF4chr20

30746317

+HM13chr20

30154013

+
ChimerDB4LUSCTCGA-66-2789TM9SF4chr20

30747914

+HM13chr20

30154012

+
ChimerDB4LUSCTCGA-66-2789TM9SF4chr20

30747914

+HM13chr20

30154013

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398022TM9SF4chr2030747914+ENST00000398174HM13chr2030154013+260519242352256673
ENST00000398022TM9SF4chr2030747914+ENST00000340852HM13chr2030154013+245819242352109624
ENST00000398022TM9SF4chr2030747914+ENST00000335574HM13chr2030154013+266119242352160641
ENST00000398022TM9SF4chr2030747914+ENST00000376127HM13chr2030154013+243319242352109624
ENST00000217315TM9SF4chr2030747914+ENST00000398174HM13chr2030154013+265919781482310720
ENST00000217315TM9SF4chr2030747914+ENST00000340852HM13chr2030154013+251219781482163671
ENST00000217315TM9SF4chr2030747914+ENST00000335574HM13chr2030154013+271519781482214688
ENST00000217315TM9SF4chr2030747914+ENST00000376127HM13chr2030154013+248719781482163671
ENST00000398022TM9SF4chr2030747914+ENST00000398174HM13chr2030154012+260519242352256673
ENST00000398022TM9SF4chr2030747914+ENST00000340852HM13chr2030154012+245819242352109624
ENST00000398022TM9SF4chr2030747914+ENST00000335574HM13chr2030154012+266119242352160641
ENST00000398022TM9SF4chr2030747914+ENST00000376127HM13chr2030154012+243319242352109624
ENST00000217315TM9SF4chr2030747914+ENST00000398174HM13chr2030154012+265919781482310720
ENST00000217315TM9SF4chr2030747914+ENST00000340852HM13chr2030154012+251219781482163671
ENST00000217315TM9SF4chr2030747914+ENST00000335574HM13chr2030154012+271519781482214688
ENST00000217315TM9SF4chr2030747914+ENST00000376127HM13chr2030154012+248719781482163671
ENST00000398022TM9SF4chr2030697558+ENST00000398174HM13chr2030137867+1213250235864209
ENST00000398022TM9SF4chr2030697558+ENST00000340852HM13chr2030137867+1066250235717160
ENST00000398022TM9SF4chr2030697558+ENST00000335574HM13chr2030137867+1269250235768177
ENST00000398022TM9SF4chr2030697558+ENST00000376127HM13chr2030137867+1041250235717160
ENST00000398022TM9SF4chr2030746317+ENST00000398174HM13chr2030154013+248518042352136633
ENST00000398022TM9SF4chr2030746317+ENST00000340852HM13chr2030154013+233818042351989584
ENST00000398022TM9SF4chr2030746317+ENST00000335574HM13chr2030154013+254118042352040601
ENST00000398022TM9SF4chr2030746317+ENST00000376127HM13chr2030154013+231318042351989584
ENST00000217315TM9SF4chr2030746317+ENST00000398174HM13chr2030154013+253918581482190680
ENST00000217315TM9SF4chr2030746317+ENST00000340852HM13chr2030154013+239218581482043631
ENST00000217315TM9SF4chr2030746317+ENST00000335574HM13chr2030154013+259518581482094648
ENST00000217315TM9SF4chr2030746317+ENST00000376127HM13chr2030154013+236718581482043631

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398022ENST00000398174TM9SF4chr2030747914+HM13chr2030154013+0.0033037770.99669623
ENST00000398022ENST00000340852TM9SF4chr2030747914+HM13chr2030154013+0.0032294640.9967706
ENST00000398022ENST00000335574TM9SF4chr2030747914+HM13chr2030154013+0.003703470.9962966
ENST00000398022ENST00000376127TM9SF4chr2030747914+HM13chr2030154013+0.0034244940.99657553
ENST00000217315ENST00000398174TM9SF4chr2030747914+HM13chr2030154013+0.0059267920.9940732
ENST00000217315ENST00000340852TM9SF4chr2030747914+HM13chr2030154013+0.0048258710.9951741
ENST00000217315ENST00000335574TM9SF4chr2030747914+HM13chr2030154013+0.0059680750.99403197
ENST00000217315ENST00000376127TM9SF4chr2030747914+HM13chr2030154013+0.0050548460.9949451
ENST00000398022ENST00000398174TM9SF4chr2030747914+HM13chr2030154012+0.0033037770.99669623
ENST00000398022ENST00000340852TM9SF4chr2030747914+HM13chr2030154012+0.0032294640.9967706
ENST00000398022ENST00000335574TM9SF4chr2030747914+HM13chr2030154012+0.003703470.9962966
ENST00000398022ENST00000376127TM9SF4chr2030747914+HM13chr2030154012+0.0034244940.99657553
ENST00000217315ENST00000398174TM9SF4chr2030747914+HM13chr2030154012+0.0059267920.9940732
ENST00000217315ENST00000340852TM9SF4chr2030747914+HM13chr2030154012+0.0048258710.9951741
ENST00000217315ENST00000335574TM9SF4chr2030747914+HM13chr2030154012+0.0059680750.99403197
ENST00000217315ENST00000376127TM9SF4chr2030747914+HM13chr2030154012+0.0050548460.9949451
ENST00000398022ENST00000398174TM9SF4chr2030697558+HM13chr2030137867+0.0090331440.99096686
ENST00000398022ENST00000340852TM9SF4chr2030697558+HM13chr2030137867+0.0092255340.99077445
ENST00000398022ENST00000335574TM9SF4chr2030697558+HM13chr2030137867+0.0148514710.98514855
ENST00000398022ENST00000376127TM9SF4chr2030697558+HM13chr2030137867+0.0096259080.9903741
ENST00000398022ENST00000398174TM9SF4chr2030746317+HM13chr2030154013+0.0041940450.995806
ENST00000398022ENST00000340852TM9SF4chr2030746317+HM13chr2030154013+0.0037819490.996218
ENST00000398022ENST00000335574TM9SF4chr2030746317+HM13chr2030154013+0.0044860680.995514
ENST00000398022ENST00000376127TM9SF4chr2030746317+HM13chr2030154013+0.0039976780.99600226
ENST00000217315ENST00000398174TM9SF4chr2030746317+HM13chr2030154013+0.0069684890.9930315
ENST00000217315ENST00000340852TM9SF4chr2030746317+HM13chr2030154013+0.0059952530.9940048
ENST00000217315ENST00000335574TM9SF4chr2030746317+HM13chr2030154013+0.0070729980.992927
ENST00000217315ENST00000376127TM9SF4chr2030746317+HM13chr2030154013+0.0062872660.9937127

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>91273_91273_1_TM9SF4-HM13_TM9SF4_chr20_30697558_ENST00000398022_HM13_chr20_30137867_ENST00000335574_length(amino acids)=177AA_BP=5
MATAMVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIF

--------------------------------------------------------------

>91273_91273_2_TM9SF4-HM13_TM9SF4_chr20_30697558_ENST00000398022_HM13_chr20_30137867_ENST00000340852_length(amino acids)=160AA_BP=5
MATAMVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIF

--------------------------------------------------------------

>91273_91273_3_TM9SF4-HM13_TM9SF4_chr20_30697558_ENST00000398022_HM13_chr20_30137867_ENST00000376127_length(amino acids)=160AA_BP=5
MATAMVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIF

--------------------------------------------------------------

>91273_91273_4_TM9SF4-HM13_TM9SF4_chr20_30697558_ENST00000398022_HM13_chr20_30137867_ENST00000398174_length(amino acids)=209AA_BP=5
MATAMVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEANNFAMLGLGDVVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIF
IMHIFKHAQPALLYLVPACIGFPVLVALAKGEVTEMFSYESSAEILPHTPRLTHFPTVSGSPASLADSMQQKLAGPRRRRPQNPSAIYEE

--------------------------------------------------------------

>91273_91273_5_TM9SF4-HM13_TM9SF4_chr20_30746317_ENST00000217315_HM13_chr20_30154013_ENST00000335574_length(amino acids)=648AA_BP=565
MTGLVFPEIHLPGPAPALRLVKAPSFGGGAVSEEDLGCCLRRFPFYFWSPPTDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIK
AVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHL
IADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADE
KSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYN
KEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRT
LKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQ
RWYMNRFVGILMAGILPFGAMFIELFFIFSPALLYLVPACIGFPVLVALAKGEVTEMFSYESSAEILPHTPRLTHFPTVSGSPASLADSM

--------------------------------------------------------------

>91273_91273_6_TM9SF4-HM13_TM9SF4_chr20_30746317_ENST00000217315_HM13_chr20_30154013_ENST00000340852_length(amino acids)=631AA_BP=565
MTGLVFPEIHLPGPAPALRLVKAPSFGGGAVSEEDLGCCLRRFPFYFWSPPTDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIK
AVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHL
IADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADE
KSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYN
KEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRT
LKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQ
RWYMNRFVGILMAGILPFGAMFIELFFIFSPALLYLVPACIGFPVLVALAKGEVTEMFSYEESNPKDPAAVTESKEGTEASASKGLEKKE

--------------------------------------------------------------

>91273_91273_7_TM9SF4-HM13_TM9SF4_chr20_30746317_ENST00000217315_HM13_chr20_30154013_ENST00000376127_length(amino acids)=631AA_BP=565
MTGLVFPEIHLPGPAPALRLVKAPSFGGGAVSEEDLGCCLRRFPFYFWSPPTDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIK
AVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHL
IADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADE
KSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYN
KEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRT
LKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQ
RWYMNRFVGILMAGILPFGAMFIELFFIFSPALLYLVPACIGFPVLVALAKGEVTEMFSYEESNPKDPAAVTESKEGTEASASKGLEKKE

--------------------------------------------------------------

>91273_91273_8_TM9SF4-HM13_TM9SF4_chr20_30746317_ENST00000217315_HM13_chr20_30154013_ENST00000398174_length(amino acids)=680AA_BP=565
MTGLVFPEIHLPGPAPALRLVKAPSFGGGAVSEEDLGCCLRRFPFYFWSPPTDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIK
AVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHL
IADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADE
KSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYN
KEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRT
LKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQ
RWYMNRFVGILMAGILPFGAMFIELFFIFSPALLYLVPACIGFPVLVALAKGEVTEMFSYESSAEILPHTPRLTHFPTVSGSPASLADSM

--------------------------------------------------------------

>91273_91273_9_TM9SF4-HM13_TM9SF4_chr20_30746317_ENST00000398022_HM13_chr20_30154013_ENST00000335574_length(amino acids)=601AA_BP=518
MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPF
QVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLH
NHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTY
LTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILI
VIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMV
ALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSPALLYLVPACIGFPVLV

--------------------------------------------------------------

>91273_91273_10_TM9SF4-HM13_TM9SF4_chr20_30746317_ENST00000398022_HM13_chr20_30154013_ENST00000340852_length(amino acids)=584AA_BP=518
MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPF
QVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLH
NHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTY
LTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILI
VIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMV
ALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSPALLYLVPACIGFPVLV

--------------------------------------------------------------

>91273_91273_11_TM9SF4-HM13_TM9SF4_chr20_30746317_ENST00000398022_HM13_chr20_30154013_ENST00000376127_length(amino acids)=584AA_BP=518
MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPF
QVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLH
NHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTY
LTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILI
VIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMV
ALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSPALLYLVPACIGFPVLV

--------------------------------------------------------------

>91273_91273_12_TM9SF4-HM13_TM9SF4_chr20_30746317_ENST00000398022_HM13_chr20_30154013_ENST00000398174_length(amino acids)=633AA_BP=518
MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPF
QVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLH
NHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTY
LTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILI
VIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMV
ALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSPALLYLVPACIGFPVLV
ALAKGEVTEMFSYESSAEILPHTPRLTHFPTVSGSPASLADSMQQKLAGPRRRRPQNPSAIYEESNPKDPAAVTESKEGTEASASKGLEK

--------------------------------------------------------------

>91273_91273_13_TM9SF4-HM13_TM9SF4_chr20_30747914_ENST00000217315_HM13_chr20_30154012_ENST00000335574_length(amino acids)=688AA_BP=610
MTGLVFPEIHLPGPAPALRLVKAPSFGGGAVSEEDLGCCLRRFPFYFWSPPTDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIK
AVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHL
IADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADE
KSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYN
KEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRT
LKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQ
RWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEPALLYLVPACIGFPVLVALA

--------------------------------------------------------------

>91273_91273_14_TM9SF4-HM13_TM9SF4_chr20_30747914_ENST00000217315_HM13_chr20_30154012_ENST00000340852_length(amino acids)=671AA_BP=610
MTGLVFPEIHLPGPAPALRLVKAPSFGGGAVSEEDLGCCLRRFPFYFWSPPTDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIK
AVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHL
IADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADE
KSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYN
KEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRT
LKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQ
RWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEPALLYLVPACIGFPVLVALA

--------------------------------------------------------------

>91273_91273_15_TM9SF4-HM13_TM9SF4_chr20_30747914_ENST00000217315_HM13_chr20_30154012_ENST00000376127_length(amino acids)=671AA_BP=610
MTGLVFPEIHLPGPAPALRLVKAPSFGGGAVSEEDLGCCLRRFPFYFWSPPTDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIK
AVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHL
IADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADE
KSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYN
KEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRT
LKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQ
RWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEPALLYLVPACIGFPVLVALA

--------------------------------------------------------------

>91273_91273_16_TM9SF4-HM13_TM9SF4_chr20_30747914_ENST00000217315_HM13_chr20_30154012_ENST00000398174_length(amino acids)=720AA_BP=610
MTGLVFPEIHLPGPAPALRLVKAPSFGGGAVSEEDLGCCLRRFPFYFWSPPTDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIK
AVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHL
IADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADE
KSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYN
KEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRT
LKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQ
RWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEPALLYLVPACIGFPVLVALA
KGEVTEMFSYESSAEILPHTPRLTHFPTVSGSPASLADSMQQKLAGPRRRRPQNPSAIYEESNPKDPAAVTESKEGTEASASKGLEKKEK

--------------------------------------------------------------

>91273_91273_17_TM9SF4-HM13_TM9SF4_chr20_30747914_ENST00000217315_HM13_chr20_30154013_ENST00000335574_length(amino acids)=688AA_BP=610
MTGLVFPEIHLPGPAPALRLVKAPSFGGGAVSEEDLGCCLRRFPFYFWSPPTDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIK
AVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHL
IADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADE
KSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYN
KEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRT
LKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQ
RWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEPALLYLVPACIGFPVLVALA

--------------------------------------------------------------

>91273_91273_18_TM9SF4-HM13_TM9SF4_chr20_30747914_ENST00000217315_HM13_chr20_30154013_ENST00000340852_length(amino acids)=671AA_BP=610
MTGLVFPEIHLPGPAPALRLVKAPSFGGGAVSEEDLGCCLRRFPFYFWSPPTDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIK
AVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHL
IADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADE
KSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYN
KEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRT
LKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQ
RWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEPALLYLVPACIGFPVLVALA

--------------------------------------------------------------

>91273_91273_19_TM9SF4-HM13_TM9SF4_chr20_30747914_ENST00000217315_HM13_chr20_30154013_ENST00000376127_length(amino acids)=671AA_BP=610
MTGLVFPEIHLPGPAPALRLVKAPSFGGGAVSEEDLGCCLRRFPFYFWSPPTDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIK
AVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHL
IADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADE
KSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYN
KEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRT
LKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQ
RWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEPALLYLVPACIGFPVLVALA

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>91273_91273_20_TM9SF4-HM13_TM9SF4_chr20_30747914_ENST00000217315_HM13_chr20_30154013_ENST00000398174_length(amino acids)=720AA_BP=610
MTGLVFPEIHLPGPAPALRLVKAPSFGGGAVSEEDLGCCLRRFPFYFWSPPTDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIK
AVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHL
IADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADE
KSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYN
KEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRT
LKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQ
RWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEPALLYLVPACIGFPVLVALA
KGEVTEMFSYESSAEILPHTPRLTHFPTVSGSPASLADSMQQKLAGPRRRRPQNPSAIYEESNPKDPAAVTESKEGTEASASKGLEKKEK

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>91273_91273_21_TM9SF4-HM13_TM9SF4_chr20_30747914_ENST00000398022_HM13_chr20_30154012_ENST00000335574_length(amino acids)=641AA_BP=563
MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPF
QVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLH
NHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTY
LTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILI
VIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMV
ALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLV
FIILVVSCSQISIVMVYFQLCAEPALLYLVPACIGFPVLVALAKGEVTEMFSYESSAEILPHTPRLTHFPTVSGSPASLADSMQQKLAGP

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>91273_91273_22_TM9SF4-HM13_TM9SF4_chr20_30747914_ENST00000398022_HM13_chr20_30154012_ENST00000340852_length(amino acids)=624AA_BP=563
MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPF
QVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLH
NHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTY
LTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILI
VIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMV
ALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLV

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>91273_91273_23_TM9SF4-HM13_TM9SF4_chr20_30747914_ENST00000398022_HM13_chr20_30154012_ENST00000376127_length(amino acids)=624AA_BP=563
MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPF
QVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLH
NHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTY
LTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILI
VIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMV
ALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLV

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>91273_91273_24_TM9SF4-HM13_TM9SF4_chr20_30747914_ENST00000398022_HM13_chr20_30154012_ENST00000398174_length(amino acids)=673AA_BP=563
MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPF
QVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLH
NHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTY
LTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILI
VIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMV
ALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLV
FIILVVSCSQISIVMVYFQLCAEPALLYLVPACIGFPVLVALAKGEVTEMFSYESSAEILPHTPRLTHFPTVSGSPASLADSMQQKLAGP

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>91273_91273_25_TM9SF4-HM13_TM9SF4_chr20_30747914_ENST00000398022_HM13_chr20_30154013_ENST00000335574_length(amino acids)=641AA_BP=563
MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPF
QVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLH
NHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTY
LTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILI
VIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMV
ALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLV
FIILVVSCSQISIVMVYFQLCAEPALLYLVPACIGFPVLVALAKGEVTEMFSYESSAEILPHTPRLTHFPTVSGSPASLADSMQQKLAGP

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>91273_91273_26_TM9SF4-HM13_TM9SF4_chr20_30747914_ENST00000398022_HM13_chr20_30154013_ENST00000340852_length(amino acids)=624AA_BP=563
MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPF
QVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLH
NHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTY
LTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILI
VIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMV
ALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLV

--------------------------------------------------------------

>91273_91273_27_TM9SF4-HM13_TM9SF4_chr20_30747914_ENST00000398022_HM13_chr20_30154013_ENST00000376127_length(amino acids)=624AA_BP=563
MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPF
QVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLH
NHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTY
LTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILI
VIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMV
ALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLV

--------------------------------------------------------------

>91273_91273_28_TM9SF4-HM13_TM9SF4_chr20_30747914_ENST00000398022_HM13_chr20_30154013_ENST00000398174_length(amino acids)=673AA_BP=563
MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPF
QVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLH
NHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTY
LTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILI
VIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMV
ALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLV
FIILVVSCSQISIVMVYFQLCAEPALLYLVPACIGFPVLVALAKGEVTEMFSYESSAEILPHTPRLTHFPTVSGSPASLADSMQQKLAGP

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:30747914/chr20:30154013)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HM13

Q8TCT9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity). {ECO:0000250|UniProtKB:Q9D8V0, ECO:0000269|PubMed:11714810, ECO:0000269|PubMed:12077416, ECO:0000269|PubMed:12145199, ECO:0000269|PubMed:14741365, ECO:0000269|PubMed:25239945}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+151824_281506.0626.0Topological domainExtracellular
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+1518303_346506.0626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+1518368_376506.0626.0Topological domainExtracellular
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+1518398_416506.0626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+1518438_449506.0626.0Topological domainExtracellular
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+1518471_501506.0626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+151824_281523.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+1518303_346523.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+1518368_376523.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+1518398_416523.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+1518438_449523.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+1518471_501523.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+161824_281546.0626.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+1618303_346546.0626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+1618368_376546.0626.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+1618398_416546.0626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+1618438_449546.0626.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+1618471_501546.0626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+1618523_535546.0626.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+161824_281563.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+1618303_346563.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+1618368_376563.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+1618398_416563.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+1618438_449563.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+1618471_501563.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+1618523_535563.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+161824_281546.0626.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+1618303_346546.0626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+1618368_376546.0626.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+1618398_416546.0626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+1618438_449546.0626.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+1618471_501546.0626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+1618523_535546.0626.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+161824_281563.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+1618303_346563.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+1618368_376563.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+1618398_416563.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+1618438_449563.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+1618471_501563.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+1618523_535563.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+1518282_302506.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+1518347_367506.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+1518377_397506.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+1518417_437506.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+1518450_470506.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+1518282_302523.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+1518347_367523.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+1518377_397523.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+1518417_437523.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+1518450_470523.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+1518502_522523.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+1618282_302546.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+1618347_367546.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+1618377_397546.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+1618417_437546.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+1618450_470546.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+1618502_522546.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+1618282_302563.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+1618347_367563.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+1618377_397563.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+1618417_437563.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+1618450_470563.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+1618502_522563.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+1618536_556563.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+1618282_302546.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+1618347_367546.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+1618377_397546.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+1618417_437546.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+1618450_470546.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+1618502_522546.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+1618282_302563.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+1618347_367563.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+1618377_397563.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+1618417_437563.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+1618450_470563.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+1618502_522563.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+1618536_556563.0643.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000335574513317_319222.0442.0MotifNote=PAL
TgeneHM13chr20:30697558chr20:30137867ENST00000340852512317_319222.0378.0MotifNote=PAL
TgeneHM13chr20:30697558chr20:30137867ENST00000376127411317_319180.0336.0MotifNote=PAL
TgeneHM13chr20:30697558chr20:30137867ENST00000398174513317_319222.0427.0MotifNote=PAL
TgeneHM13chr20:30746317chr20:30154013ENST00000335574913317_319316.0442.0MotifNote=PAL
TgeneHM13chr20:30746317chr20:30154013ENST00000340852912317_319316.0378.0MotifNote=PAL
TgeneHM13chr20:30746317chr20:30154013ENST00000376127811317_319274.0336.0MotifNote=PAL
TgeneHM13chr20:30746317chr20:30154013ENST00000398174913317_319316.0427.0MotifNote=PAL
TgeneHM13chr20:30747914chr20:30154012ENST00000335574913317_319316.0442.0MotifNote=PAL
TgeneHM13chr20:30747914chr20:30154012ENST00000340852912317_319316.0378.0MotifNote=PAL
TgeneHM13chr20:30747914chr20:30154012ENST00000376127811317_319274.0336.0MotifNote=PAL
TgeneHM13chr20:30747914chr20:30154012ENST00000398174913317_319316.0427.0MotifNote=PAL
TgeneHM13chr20:30747914chr20:30154013ENST00000335574913317_319316.0442.0MotifNote=PAL
TgeneHM13chr20:30747914chr20:30154013ENST00000340852912317_319316.0378.0MotifNote=PAL
TgeneHM13chr20:30747914chr20:30154013ENST00000376127811317_319274.0336.0MotifNote=PAL
TgeneHM13chr20:30747914chr20:30154013ENST00000398174913317_319316.0427.0MotifNote=PAL
TgeneHM13chr20:30697558chr20:30137867ENST00000335574513231_256222.0442.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST00000335574513278_290222.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST00000335574513312_314222.0442.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST00000335574513336_377222.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST00000340852512231_256222.0378.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST00000340852512278_290222.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST00000340852512312_314222.0378.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST00000340852512336_377222.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST00000376127411179_181180.0336.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST00000376127411203_209180.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST00000376127411231_256180.0336.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST00000376127411278_290180.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST00000376127411312_314180.0336.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST00000376127411336_377180.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST00000398174513231_256222.0427.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST00000398174513278_290222.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST00000398174513312_314222.0427.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST00000398174513336_377222.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST00000335574913336_377316.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST00000340852912336_377316.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST00000376127811278_290274.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST00000376127811312_314274.0336.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST00000376127811336_377274.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST00000398174913336_377316.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST00000335574913336_377316.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST00000340852912336_377316.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST00000376127811278_290274.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST00000376127811312_314274.0336.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST00000376127811336_377274.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST00000398174913336_377316.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST00000335574913336_377316.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST00000340852912336_377316.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST00000376127811278_290274.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST00000376127811312_314274.0336.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST00000376127811336_377274.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST00000398174913336_377316.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST00000335574513257_277222.0442.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000335574513291_311222.0442.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000335574513315_335222.0442.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000340852512257_277222.0378.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000340852512291_311222.0378.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000340852512315_335222.0378.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000376127411182_202180.0336.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000376127411210_230180.0336.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000376127411257_277180.0336.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000376127411291_311180.0336.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000376127411315_335180.0336.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000398174513257_277222.0427.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000398174513291_311222.0427.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000398174513315_335222.0427.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000335574913315_335316.0442.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000340852912315_335316.0378.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000376127811291_311274.0336.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000376127811315_335274.0336.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000398174913315_335316.0427.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000335574913315_335316.0442.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000340852912315_335316.0378.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000376127811291_311274.0336.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000376127811315_335274.0336.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000398174913315_335316.0427.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000335574913315_335316.0442.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000340852912315_335316.0378.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000376127811291_311274.0336.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000376127811315_335274.0336.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000398174913315_335316.0427.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+11824_2810626.0Topological domainExtracellular
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+118303_3460626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+118368_3760626.0Topological domainExtracellular
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+118398_4160626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+118438_4490626.0Topological domainExtracellular
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+118471_5010626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+118523_5350626.0Topological domainExtracellular
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+118557_5700626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+118592_5980626.0Topological domainExtracellular
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+118620_6420626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+11824_2815.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+118303_3465.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+118368_3765.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+118398_4165.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+118438_4495.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+118471_5015.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+118523_5355.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+118557_5705.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+118592_5985.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+118620_6425.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+1518523_535506.0626.0Topological domainExtracellular
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+1518557_570506.0626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+1518592_598506.0626.0Topological domainExtracellular
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+1518620_642506.0626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+1518523_535523.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+1518557_570523.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+1518592_598523.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+1518620_642523.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+1618557_570546.0626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+1618592_598546.0626.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+1618620_642546.0626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+1618557_570563.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+1618592_598563.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+1618620_642563.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+1618557_570546.0626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+1618592_598546.0626.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+1618620_642546.0626.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+1618557_570563.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+1618592_598563.0643.0Topological domainExtracellular
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+1618620_642563.0643.0Topological domainCytoplasmic
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+118282_3020626.0TransmembraneHelical
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+118347_3670626.0TransmembraneHelical
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+118377_3970626.0TransmembraneHelical
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+118417_4370626.0TransmembraneHelical
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+118450_4700626.0TransmembraneHelical
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+118502_5220626.0TransmembraneHelical
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+118536_5560626.0TransmembraneHelical
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+118571_5910626.0TransmembraneHelical
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000217315+118599_6190626.0TransmembraneHelical
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+118282_3025.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+118347_3675.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+118377_3975.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+118417_4375.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+118450_4705.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+118502_5225.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+118536_5565.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+118571_5915.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30697558chr20:30137867ENST00000398022+118599_6195.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+1518502_522506.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+1518536_556506.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+1518571_591506.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000217315+1518599_619506.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+1518536_556523.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+1518571_591523.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30746317chr20:30154013ENST00000398022+1518599_619523.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+1618536_556546.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+1618571_591546.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000217315+1618599_619546.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+1618571_591563.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154012ENST00000398022+1618599_619563.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+1618536_556546.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+1618571_591546.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000217315+1618599_619546.0626.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+1618571_591563.0643.0TransmembraneHelical
HgeneTM9SF4chr20:30747914chr20:30154013ENST00000398022+1618599_619563.0643.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000335574513122_157222.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST00000335574513179_181222.0442.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST000003355745131_31222.0442.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST00000335574513203_209222.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST0000033557451353_77222.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST0000033557451399_100222.0442.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST00000340852512122_157222.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST00000340852512179_181222.0378.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST000003408525121_31222.0378.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST00000340852512203_209222.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST0000034085251253_77222.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST0000034085251299_100222.0378.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST00000376127411122_157180.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST000003761274111_31180.0336.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST0000037612741153_77180.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST0000037612741199_100180.0336.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST00000398174513122_157222.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST00000398174513179_181222.0427.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST000003981745131_31222.0427.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST00000398174513203_209222.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST0000039817451353_77222.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30697558chr20:30137867ENST0000039817451399_100222.0427.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST00000335574913122_157316.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST00000335574913179_181316.0442.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST000003355749131_31316.0442.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST00000335574913203_209316.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST00000335574913231_256316.0442.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST00000335574913278_290316.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST00000335574913312_314316.0442.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST0000033557491353_77316.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST0000033557491399_100316.0442.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST00000340852912122_157316.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST00000340852912179_181316.0378.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST000003408529121_31316.0378.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST00000340852912203_209316.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST00000340852912231_256316.0378.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST00000340852912278_290316.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST00000340852912312_314316.0378.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST0000034085291253_77316.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST0000034085291299_100316.0378.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST00000376127811122_157274.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST00000376127811179_181274.0336.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST000003761278111_31274.0336.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST00000376127811203_209274.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST00000376127811231_256274.0336.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST0000037612781153_77274.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST0000037612781199_100274.0336.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST00000398174913122_157316.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST00000398174913179_181316.0427.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST000003981749131_31316.0427.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST00000398174913203_209316.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST00000398174913231_256316.0427.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST00000398174913278_290316.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST00000398174913312_314316.0427.0Topological domainLumenal
TgeneHM13chr20:30746317chr20:30154013ENST0000039817491353_77316.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30746317chr20:30154013ENST0000039817491399_100316.0427.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST00000335574913122_157316.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST00000335574913179_181316.0442.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST000003355749131_31316.0442.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST00000335574913203_209316.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST00000335574913231_256316.0442.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST00000335574913278_290316.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST00000335574913312_314316.0442.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST0000033557491353_77316.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST0000033557491399_100316.0442.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST00000340852912122_157316.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST00000340852912179_181316.0378.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST000003408529121_31316.0378.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST00000340852912203_209316.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST00000340852912231_256316.0378.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST00000340852912278_290316.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST00000340852912312_314316.0378.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST0000034085291253_77316.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST0000034085291299_100316.0378.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST00000376127811122_157274.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST00000376127811179_181274.0336.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST000003761278111_31274.0336.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST00000376127811203_209274.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST00000376127811231_256274.0336.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST0000037612781153_77274.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST0000037612781199_100274.0336.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST00000398174913122_157316.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST00000398174913179_181316.0427.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST000003981749131_31316.0427.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST00000398174913203_209316.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST00000398174913231_256316.0427.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST00000398174913278_290316.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST00000398174913312_314316.0427.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154012ENST0000039817491353_77316.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154012ENST0000039817491399_100316.0427.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST00000335574913122_157316.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST00000335574913179_181316.0442.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST000003355749131_31316.0442.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST00000335574913203_209316.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST00000335574913231_256316.0442.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST00000335574913278_290316.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST00000335574913312_314316.0442.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST0000033557491353_77316.0442.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST0000033557491399_100316.0442.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST00000340852912122_157316.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST00000340852912179_181316.0378.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST000003408529121_31316.0378.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST00000340852912203_209316.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST00000340852912231_256316.0378.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST00000340852912278_290316.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST00000340852912312_314316.0378.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST0000034085291253_77316.0378.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST0000034085291299_100316.0378.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST00000376127811122_157274.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST00000376127811179_181274.0336.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST000003761278111_31274.0336.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST00000376127811203_209274.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST00000376127811231_256274.0336.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST0000037612781153_77274.0336.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST0000037612781199_100274.0336.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST00000398174913122_157316.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST00000398174913179_181316.0427.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST000003981749131_31316.0427.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST00000398174913203_209316.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST00000398174913231_256316.0427.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST00000398174913278_290316.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST00000398174913312_314316.0427.0Topological domainLumenal
TgeneHM13chr20:30747914chr20:30154013ENST0000039817491353_77316.0427.0Topological domainCytoplasmic
TgeneHM13chr20:30747914chr20:30154013ENST0000039817491399_100316.0427.0Topological domainLumenal
TgeneHM13chr20:30697558chr20:30137867ENST00000335574513101_121222.0442.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000335574513158_178222.0442.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000335574513182_202222.0442.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000335574513210_230222.0442.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST0000033557451332_52222.0442.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST0000033557451378_98222.0442.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000340852512101_121222.0378.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000340852512158_178222.0378.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000340852512182_202222.0378.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000340852512210_230222.0378.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST0000034085251232_52222.0378.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST0000034085251278_98222.0378.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000376127411101_121180.0336.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000376127411158_178180.0336.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST0000037612741132_52180.0336.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST0000037612741178_98180.0336.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000398174513101_121222.0427.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000398174513158_178222.0427.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000398174513182_202222.0427.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST00000398174513210_230222.0427.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST0000039817451332_52222.0427.0TransmembraneHelical
TgeneHM13chr20:30697558chr20:30137867ENST0000039817451378_98222.0427.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000335574913101_121316.0442.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000335574913158_178316.0442.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000335574913182_202316.0442.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000335574913210_230316.0442.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000335574913257_277316.0442.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000335574913291_311316.0442.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST0000033557491332_52316.0442.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST0000033557491378_98316.0442.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000340852912101_121316.0378.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000340852912158_178316.0378.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000340852912182_202316.0378.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000340852912210_230316.0378.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000340852912257_277316.0378.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000340852912291_311316.0378.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST0000034085291232_52316.0378.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST0000034085291278_98316.0378.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000376127811101_121274.0336.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000376127811158_178274.0336.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000376127811182_202274.0336.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000376127811210_230274.0336.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000376127811257_277274.0336.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST0000037612781132_52274.0336.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST0000037612781178_98274.0336.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000398174913101_121316.0427.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000398174913158_178316.0427.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000398174913182_202316.0427.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000398174913210_230316.0427.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000398174913257_277316.0427.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST00000398174913291_311316.0427.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST0000039817491332_52316.0427.0TransmembraneHelical
TgeneHM13chr20:30746317chr20:30154013ENST0000039817491378_98316.0427.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000335574913101_121316.0442.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000335574913158_178316.0442.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000335574913182_202316.0442.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000335574913210_230316.0442.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000335574913257_277316.0442.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000335574913291_311316.0442.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST0000033557491332_52316.0442.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST0000033557491378_98316.0442.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000340852912101_121316.0378.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000340852912158_178316.0378.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000340852912182_202316.0378.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000340852912210_230316.0378.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000340852912257_277316.0378.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000340852912291_311316.0378.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST0000034085291232_52316.0378.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST0000034085291278_98316.0378.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000376127811101_121274.0336.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000376127811158_178274.0336.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000376127811182_202274.0336.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000376127811210_230274.0336.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000376127811257_277274.0336.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST0000037612781132_52274.0336.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST0000037612781178_98274.0336.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000398174913101_121316.0427.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000398174913158_178316.0427.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000398174913182_202316.0427.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000398174913210_230316.0427.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000398174913257_277316.0427.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST00000398174913291_311316.0427.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST0000039817491332_52316.0427.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154012ENST0000039817491378_98316.0427.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000335574913101_121316.0442.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000335574913158_178316.0442.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000335574913182_202316.0442.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000335574913210_230316.0442.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000335574913257_277316.0442.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000335574913291_311316.0442.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST0000033557491332_52316.0442.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST0000033557491378_98316.0442.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000340852912101_121316.0378.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000340852912158_178316.0378.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000340852912182_202316.0378.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000340852912210_230316.0378.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000340852912257_277316.0378.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000340852912291_311316.0378.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST0000034085291232_52316.0378.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST0000034085291278_98316.0378.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000376127811101_121274.0336.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000376127811158_178274.0336.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000376127811182_202274.0336.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000376127811210_230274.0336.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000376127811257_277274.0336.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST0000037612781132_52274.0336.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST0000037612781178_98274.0336.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000398174913101_121316.0427.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000398174913158_178316.0427.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000398174913182_202316.0427.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000398174913210_230316.0427.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000398174913257_277316.0427.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST00000398174913291_311316.0427.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST0000039817491332_52316.0427.0TransmembraneHelical
TgeneHM13chr20:30747914chr20:30154013ENST0000039817491378_98316.0427.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1468_TM9SF4_30747914_HM13_30154013_ranked_0.pdbTM9SF43074631730747914ENST00000376127HM13chr2030154013+
MTGLVFPEIHLPGPAPALRLVKAPSFGGGAVSEEDLGCCLRRFPFYFWSPPTDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIK
AVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHL
IADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADE
KSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYN
KEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRT
LKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQ
RWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEPALLYLVPACIGFPVLVALA
KGEVTEMFSYESSAEILPHTPRLTHFPTVSGSPASLADSMQQKLAGPRRRRPQNPSAIYEESNPKDPAAVTESKEGTEASASKGLEKKEK
720


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TM9SF4_pLDDT.png
all structure
all structure
HM13_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TM9SF4
HM13


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TM9SF4-HM13


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TM9SF4-HM13


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource