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Fusion Protein:TMED4-ENG |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: TMED4-ENG | FusionPDB ID: 91461 | FusionGDB2.0 ID: 91461 | Hgene | Tgene | Gene symbol | TMED4 | ENG | Gene ID | 222068 | 2022 |
Gene name | transmembrane p24 trafficking protein 4 | endoglin | |
Synonyms | ERS25|GMP25iso|HNLF|p24a3|p24alpha3 | END|HHT1|ORW1 | |
Cytomap | 7p13 | 9q34.11 | |
Type of gene | protein-coding | protein-coding | |
Description | transmembrane emp24 domain-containing protein 4endoplasmic reticulum stress-response protein 25 kDap24 family protein alpha-3putative NF-kappa-B-activating protein 156putative NFkB activating protein HNLFtransmembrane emp24 protein transport domain c | endoglinCD105 antigen | |
Modification date | 20200320 | 20200329 | |
UniProtAcc | . | Q8NFI3 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000444131, ENST00000457408, ENST00000289577, ENST00000481238, | ENST00000480266, ENST00000344849, ENST00000373203, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 3 X 2 X 1=6 | 6 X 7 X 4=168 |
# samples | 3 | 6 | |
** MAII score | log2(3/6*10)=2.32192809488736 | log2(6/168*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: TMED4 [Title/Abstract] AND ENG [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | TMED4(44620692)-ENG(130581112), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | TMED4-ENG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TMED4-ENG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TMED4-ENG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TMED4-ENG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TMED4-ENG seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ENG | GO:0001934 | positive regulation of protein phosphorylation | 12015308 |
Tgene | ENG | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | 12015308 |
Tgene | ENG | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 15702480 |
Tgene | ENG | GO:0030336 | negative regulation of cell migration | 19736306 |
Tgene | ENG | GO:0030513 | positive regulation of BMP signaling pathway | 17068149 |
Tgene | ENG | GO:0031953 | negative regulation of protein autophosphorylation | 12015308 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS5.0 | N/A | AK123738 | TMED4 | chr7 | 44620692 | - | ENG | chr9 | 130581112 | - |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000457408 | TMED4 | chr7 | 44620692 | - | ENST00000373203 | ENG | chr9 | 130581112 | - | 1923 | 587 | 53 | 1252 | 399 |
ENST00000457408 | TMED4 | chr7 | 44620692 | - | ENST00000344849 | ENG | chr9 | 130581112 | - | 2054 | 587 | 53 | 1153 | 366 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000457408 | ENST00000373203 | TMED4 | chr7 | 44620692 | - | ENG | chr9 | 130581112 | - | 0.051467583 | 0.9485324 |
ENST00000457408 | ENST00000344849 | TMED4 | chr7 | 44620692 | - | ENG | chr9 | 130581112 | - | 0.027866034 | 0.97213393 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >91461_91461_1_TMED4-ENG_TMED4_chr7_44620692_ENST00000457408_ENG_chr9_130581112_ENST00000344849_length(amino acids)=366AA_BP=178 MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPDGKVVL SRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRKK VHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPR FSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGLVLPAVLGITFGAFLIGALLTAALWYIYSHTRE -------------------------------------------------------------- >91461_91461_2_TMED4-ENG_TMED4_chr7_44620692_ENST00000457408_ENG_chr9_130581112_ENST00000373203_length(amino acids)=399AA_BP=178 MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPDGKVVL SRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRKK VHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPR FSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGLVLPAVLGITFGAFLIGALLTAALWYIYSHTRS -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:44620692/chr9:130581112) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | ENG |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol. {ECO:0000269|PubMed:12114544}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TMED4 | chr7:44620692 | chr9:130581112 | ENST00000457408 | - | 4 | 5 | 147_176 | 178.0 | 228.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TMED4 | chr7:44620692 | chr9:130581112 | ENST00000457408 | - | 4 | 5 | 39_137 | 178.0 | 228.0 | Domain | GOLD |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000344849 | 9 | 14 | 612_658 | 437.0 | 626.0 | Topological domain | Cytoplasmic | |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000373203 | 9 | 15 | 612_658 | 437.0 | 659.0 | Topological domain | Cytoplasmic | |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000344849 | 9 | 14 | 587_611 | 437.0 | 626.0 | Transmembrane | Helical | |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000373203 | 9 | 15 | 587_611 | 437.0 | 659.0 | Transmembrane | Helical |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TMED4 | chr7:44620692 | chr9:130581112 | ENST00000481238 | - | 1 | 4 | 147_176 | 0 | 187.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | TMED4 | chr7:44620692 | chr9:130581112 | ENST00000481238 | - | 1 | 4 | 39_137 | 0 | 187.0 | Domain | GOLD |
Hgene | TMED4 | chr7:44620692 | chr9:130581112 | ENST00000457408 | - | 4 | 5 | 220_221 | 178.0 | 228.0 | Motif | COPII vesicle coat-binding |
Hgene | TMED4 | chr7:44620692 | chr9:130581112 | ENST00000457408 | - | 4 | 5 | 220_227 | 178.0 | 228.0 | Motif | COPI vesicle coat-binding |
Hgene | TMED4 | chr7:44620692 | chr9:130581112 | ENST00000481238 | - | 1 | 4 | 220_221 | 0 | 187.0 | Motif | COPII vesicle coat-binding |
Hgene | TMED4 | chr7:44620692 | chr9:130581112 | ENST00000481238 | - | 1 | 4 | 220_227 | 0 | 187.0 | Motif | COPI vesicle coat-binding |
Hgene | TMED4 | chr7:44620692 | chr9:130581112 | ENST00000457408 | - | 4 | 5 | 213_227 | 178.0 | 228.0 | Topological domain | Cytoplasmic |
Hgene | TMED4 | chr7:44620692 | chr9:130581112 | ENST00000457408 | - | 4 | 5 | 30_194 | 178.0 | 228.0 | Topological domain | Lumenal |
Hgene | TMED4 | chr7:44620692 | chr9:130581112 | ENST00000481238 | - | 1 | 4 | 213_227 | 0 | 187.0 | Topological domain | Cytoplasmic |
Hgene | TMED4 | chr7:44620692 | chr9:130581112 | ENST00000481238 | - | 1 | 4 | 30_194 | 0 | 187.0 | Topological domain | Lumenal |
Hgene | TMED4 | chr7:44620692 | chr9:130581112 | ENST00000457408 | - | 4 | 5 | 195_212 | 178.0 | 228.0 | Transmembrane | Helical |
Hgene | TMED4 | chr7:44620692 | chr9:130581112 | ENST00000481238 | - | 1 | 4 | 195_212 | 0 | 187.0 | Transmembrane | Helical |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000344849 | 9 | 14 | 336_576 | 437.0 | 626.0 | Compositional bias | Note=Ser/Thr-rich | |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000373203 | 9 | 15 | 336_576 | 437.0 | 659.0 | Compositional bias | Note=Ser/Thr-rich | |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000344849 | 9 | 14 | 363_533 | 437.0 | 626.0 | Domain | ZP | |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000373203 | 9 | 15 | 363_533 | 437.0 | 659.0 | Domain | ZP | |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000344849 | 9 | 14 | 399_401 | 437.0 | 626.0 | Motif | Cell attachment site | |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000373203 | 9 | 15 | 399_401 | 437.0 | 659.0 | Motif | Cell attachment site | |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000344849 | 9 | 14 | 200_330 | 437.0 | 626.0 | Region | OR1%2C C-terminal part | |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000344849 | 9 | 14 | 26_46 | 437.0 | 626.0 | Region | OR1%2C N-terminal part | |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000344849 | 9 | 14 | 47_199 | 437.0 | 626.0 | Region | OR2 | |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000373203 | 9 | 15 | 200_330 | 437.0 | 659.0 | Region | OR1%2C C-terminal part | |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000373203 | 9 | 15 | 26_46 | 437.0 | 659.0 | Region | OR1%2C N-terminal part | |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000373203 | 9 | 15 | 47_199 | 437.0 | 659.0 | Region | OR2 | |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000344849 | 9 | 14 | 26_586 | 437.0 | 626.0 | Topological domain | Extracellular | |
Tgene | ENG | chr7:44620692 | chr9:130581112 | ENST00000373203 | 9 | 15 | 26_586 | 437.0 | 659.0 | Topological domain | Extracellular |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
TMED4 | |
ENG |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to TMED4-ENG |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to TMED4-ENG |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |