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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TMEM138-DTNB

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TMEM138-DTNB
	FusionPDB ID: 91693
	FusionGDB2.0 ID: 91693
		Hgene	Tgene
	Gene symbol	TMEM138	DTNB
	Gene ID	51524	1838
	Gene name	transmembrane protein 138	dystrobrevin beta
	Synonyms	HSPC196	-
	Cytomap	11q12.2	2p23.3
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protein 138	dystrobrevin betaDTN-Bbeta-dystrobrevin
	Modification date	20200313	20200327
	UniProtAcc	.	Q96EV8
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000540194, ENST00000278826, ENST00000381787, ENST00000542946,	ENST00000288642, ENST00000404103, ENST00000405222, ENST00000406818, ENST00000407038, ENST00000407186, ENST00000407661, ENST00000496972, ENST00000545439, ENST00000472690,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 3 X 3=36	14 X 13 X 9=1638
	# samples	4	15
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(15/1638*10)=-3.44890095114513 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TMEM138 [Title/Abstract] AND DTNB [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TMEM138(61133688)-DTNB(25754467), # samples:2
Anticipated loss of major functional domain due to fusion event.	TMEM138-DTNB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TMEM138-DTNB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TMEM138-DTNB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TMEM138-DTNB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TMEM138 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DTNB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BQ056742	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-
ChiTaRS5.0	N/A	BQ057316	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000278826	TMEM138	chr11	61133688	+	ENST00000496972	DTNB	chr2	25754467	-	2177	859	517	1791	424
ENST00000278826	TMEM138	chr11	61133688	+	ENST00000405222	DTNB	chr2	25754467	-	2006	859	517	1665	382
ENST00000278826	TMEM138	chr11	61133688	+	ENST00000407661	DTNB	chr2	25754467	-	2153	859	517	1812	431
ENST00000278826	TMEM138	chr11	61133688	+	ENST00000406818	DTNB	chr2	25754467	-	2207	859	517	1866	449
ENST00000278826	TMEM138	chr11	61133688	+	ENST00000407038	DTNB	chr2	25754467	-	2027	859	517	1686	389
ENST00000278826	TMEM138	chr11	61133688	+	ENST00000404103	DTNB	chr2	25754467	-	2117	859	517	1776	419
ENST00000278826	TMEM138	chr11	61133688	+	ENST00000407186	DTNB	chr2	25754467	-	2081	859	517	1755	412
ENST00000278826	TMEM138	chr11	61133688	+	ENST00000288642	DTNB	chr2	25754467	-	2098	859	517	1776	419
ENST00000278826	TMEM138	chr11	61133688	+	ENST00000545439	DTNB	chr2	25754467	-	1913	859	517	1845	442
ENST00000542946	TMEM138	chr11	61133688	+	ENST00000496972	DTNB	chr2	25754467	-	3985	2667	2685	3599	304
ENST00000542946	TMEM138	chr11	61133688	+	ENST00000405222	DTNB	chr2	25754467	-	3814	2667	2685	3473	262
ENST00000542946	TMEM138	chr11	61133688	+	ENST00000407661	DTNB	chr2	25754467	-	3961	2667	2685	3620	311
ENST00000542946	TMEM138	chr11	61133688	+	ENST00000406818	DTNB	chr2	25754467	-	4015	2667	2685	3674	329
ENST00000542946	TMEM138	chr11	61133688	+	ENST00000407038	DTNB	chr2	25754467	-	3835	2667	2685	3494	269
ENST00000542946	TMEM138	chr11	61133688	+	ENST00000404103	DTNB	chr2	25754467	-	3925	2667	2685	3584	299
ENST00000542946	TMEM138	chr11	61133688	+	ENST00000407186	DTNB	chr2	25754467	-	3889	2667	2685	3563	292
ENST00000542946	TMEM138	chr11	61133688	+	ENST00000288642	DTNB	chr2	25754467	-	3906	2667	2685	3584	299
ENST00000542946	TMEM138	chr11	61133688	+	ENST00000545439	DTNB	chr2	25754467	-	3721	2667	2685	3653	322
ENST00000381787	TMEM138	chr11	61133688	+	ENST00000496972	DTNB	chr2	25754467	-	1832	514	388	1446	352
ENST00000381787	TMEM138	chr11	61133688	+	ENST00000405222	DTNB	chr2	25754467	-	1661	514	388	1320	310
ENST00000381787	TMEM138	chr11	61133688	+	ENST00000407661	DTNB	chr2	25754467	-	1808	514	388	1467	359
ENST00000381787	TMEM138	chr11	61133688	+	ENST00000406818	DTNB	chr2	25754467	-	1862	514	388	1521	377
ENST00000381787	TMEM138	chr11	61133688	+	ENST00000407038	DTNB	chr2	25754467	-	1682	514	388	1341	317
ENST00000381787	TMEM138	chr11	61133688	+	ENST00000404103	DTNB	chr2	25754467	-	1772	514	388	1431	347
ENST00000381787	TMEM138	chr11	61133688	+	ENST00000407186	DTNB	chr2	25754467	-	1736	514	388	1410	340
ENST00000381787	TMEM138	chr11	61133688	+	ENST00000288642	DTNB	chr2	25754467	-	1753	514	388	1431	347
ENST00000381787	TMEM138	chr11	61133688	+	ENST00000545439	DTNB	chr2	25754467	-	1568	514	388	1500	370

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000278826	ENST00000496972	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.004082692	0.9959174
ENST00000278826	ENST00000405222	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.001640959	0.998359
ENST00000278826	ENST00000407661	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.002844395	0.99715555
ENST00000278826	ENST00000406818	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.00230111	0.99769884
ENST00000278826	ENST00000407038	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.001550657	0.9984493
ENST00000278826	ENST00000404103	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.001740213	0.99825984
ENST00000278826	ENST00000407186	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.002246826	0.9977532
ENST00000278826	ENST00000288642	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.001550854	0.9984491
ENST00000278826	ENST00000545439	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.002032299	0.99796766
ENST00000542946	ENST00000496972	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.019232836	0.98076713
ENST00000542946	ENST00000405222	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.0057182	0.99428177
ENST00000542946	ENST00000407661	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.008076492	0.9919235
ENST00000542946	ENST00000406818	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.003900545	0.9960995
ENST00000542946	ENST00000407038	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.006405848	0.9935941
ENST00000542946	ENST00000404103	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.005060243	0.9949398
ENST00000542946	ENST00000407186	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.008583773	0.9914163
ENST00000542946	ENST00000288642	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.004427766	0.9955722
ENST00000542946	ENST00000545439	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.005315623	0.9946844
ENST00000381787	ENST00000496972	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.005343038	0.99465704
ENST00000381787	ENST00000405222	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.003465923	0.9965341
ENST00000381787	ENST00000407661	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.003128065	0.996872
ENST00000381787	ENST00000406818	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.002403462	0.99759656
ENST00000381787	ENST00000407038	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.002599432	0.99740064
ENST00000381787	ENST00000404103	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.001836331	0.99816364
ENST00000381787	ENST00000407186	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.003214988	0.99678504
ENST00000381787	ENST00000288642	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.001766647	0.9982333
ENST00000381787	ENST00000545439	TMEM138	chr11	61133688	+	DTNB	chr2	25754467	-	0.002158823	0.9978411

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>91693_91693_1_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000278826_DTNB_chr2_25754467_ENST00000288642_length(amino acids)=419AA_BP=114
MWDVPLGARENRRKMLQTSNYSLVLSLQFLLLSYDLFVNSFSELLQKTPVIQLVLFIIQDIAVLFNIIIIFLMFFNTFVFQAGLVNLLFH
KFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPT
KRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNR
EILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEAEARESAQATGSPHTSPTH

--------------------------------------------------------------

>91693_91693_2_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000278826_DTNB_chr2_25754467_ENST00000404103_length(amino acids)=419AA_BP=114
MWDVPLGARENRRKMLQTSNYSLVLSLQFLLLSYDLFVNSFSELLQKTPVIQLVLFIIQDIAVLFNIIIIFLMFFNTFVFQAGLVNLLFH
KFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPT
KRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNR
EILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTH

--------------------------------------------------------------

>91693_91693_3_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000278826_DTNB_chr2_25754467_ENST00000405222_length(amino acids)=382AA_BP=114
MWDVPLGARENRRKMLQTSNYSLVLSLQFLLLSYDLFVNSFSELLQKTPVIQLVLFIIQDIAVLFNIIIIFLMFFNTFVFQAGLVNLLFH
KFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPT
KSVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTL
LAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGVGGDVQEA

--------------------------------------------------------------

>91693_91693_4_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000278826_DTNB_chr2_25754467_ENST00000406818_length(amino acids)=449AA_BP=114
MWDVPLGARENRRKMLQTSNYSLVLSLQFLLLSYDLFVNSFSELLQKTPVIQLVLFIIQDIAVLFNIIIIFLMFFNTFVFQAGLVNLLFH
KFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPT
KRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNR
EILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTH

--------------------------------------------------------------

>91693_91693_5_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000278826_DTNB_chr2_25754467_ENST00000407038_length(amino acids)=389AA_BP=114
MWDVPLGARENRRKMLQTSNYSLVLSLQFLLLSYDLFVNSFSELLQKTPVIQLVLFIIQDIAVLFNIIIIFLMFFNTFVFQAGLVNLLFH
KFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPT
KSVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTL
LAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGV

--------------------------------------------------------------

>91693_91693_6_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000278826_DTNB_chr2_25754467_ENST00000407186_length(amino acids)=412AA_BP=114
MWDVPLGARENRRKMLQTSNYSLVLSLQFLLLSYDLFVNSFSELLQKTPVIQLVLFIIQDIAVLFNIIIIFLMFFNTFVFQAGLVNLLFH
KFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPT
KSVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTL
LAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGVGGDVQEA

--------------------------------------------------------------

>91693_91693_7_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000278826_DTNB_chr2_25754467_ENST00000407661_length(amino acids)=431AA_BP=114
MWDVPLGARENRRKMLQTSNYSLVLSLQFLLLSYDLFVNSFSELLQKTPVIQLVLFIIQDIAVLFNIIIIFLMFFNTFVFQAGLVNLLFH
KFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPT
KRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNR
EILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTH

--------------------------------------------------------------

>91693_91693_8_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000278826_DTNB_chr2_25754467_ENST00000496972_length(amino acids)=424AA_BP=114
MWDVPLGARENRRKMLQTSNYSLVLSLQFLLLSYDLFVNSFSELLQKTPVIQLVLFIIQDIAVLFNIIIIFLMFFNTFVFQAGLVNLLFH
KFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPT
KRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNR
EILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMP

--------------------------------------------------------------

>91693_91693_9_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000278826_DTNB_chr2_25754467_ENST00000545439_length(amino acids)=442AA_BP=114
MWDVPLGARENRRKMLQTSNYSLVLSLQFLLLSYDLFVNSFSELLQKTPVIQLVLFIIQDIAVLFNIIIIFLMFFNTFVFQAGLVNLLFH
KFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPT
KRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNR
EILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMP

--------------------------------------------------------------

>91693_91693_10_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000381787_DTNB_chr2_25754467_ENST00000288642_length(amino acids)=347AA_BP=42
MFFNTFVFQAGLVNLLFHKFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLT
NMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNF
DANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEA

--------------------------------------------------------------

>91693_91693_11_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000381787_DTNB_chr2_25754467_ENST00000404103_length(amino acids)=347AA_BP=42
MFFNTFVFQAGLVNLLFHKFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLT
NMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNF
DANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEE

--------------------------------------------------------------

>91693_91693_12_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000381787_DTNB_chr2_25754467_ENST00000405222_length(amino acids)=310AA_BP=42
MFFNTFVFQAGLVNLLFHKFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLT
NMNDTMVSHMSSGVPTPTKSVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLE
HEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTP

--------------------------------------------------------------

>91693_91693_13_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000381787_DTNB_chr2_25754467_ENST00000406818_length(amino acids)=377AA_BP=42
MFFNTFVFQAGLVNLLFHKFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLT
NMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNF
DANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEE
EQKQAAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGVGGDVQEAFAQGTRRNLRNDLLVAADSITNTMSSLVKELHSAE

--------------------------------------------------------------

>91693_91693_14_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000381787_DTNB_chr2_25754467_ENST00000407038_length(amino acids)=317AA_BP=42
MFFNTFVFQAGLVNLLFHKFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLT
NMNDTMVSHMSSGVPTPTKSVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLE
HEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRS

--------------------------------------------------------------

>91693_91693_15_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000381787_DTNB_chr2_25754467_ENST00000407186_length(amino acids)=340AA_BP=42
MFFNTFVFQAGLVNLLFHKFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLT
NMNDTMVSHMSSGVPTPTKSVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLE
HEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTP

--------------------------------------------------------------

>91693_91693_16_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000381787_DTNB_chr2_25754467_ENST00000407661_length(amino acids)=359AA_BP=42
MFFNTFVFQAGLVNLLFHKFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLT
NMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNF
DANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEE

--------------------------------------------------------------

>91693_91693_17_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000381787_DTNB_chr2_25754467_ENST00000496972_length(amino acids)=352AA_BP=42
MFFNTFVFQAGLVNLLFHKFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLT
NMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNF
DANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQ

--------------------------------------------------------------

>91693_91693_18_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000381787_DTNB_chr2_25754467_ENST00000545439_length(amino acids)=370AA_BP=42
MFFNTFVFQAGLVNLLFHKFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLT
NMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNF
DANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQ
ATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGVGGDVQEAFAQGTRRNLRNDLLVAADSITNTMSSLVKELHSAEEGAEEEE

--------------------------------------------------------------

>91693_91693_19_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000542946_DTNB_chr2_25754467_ENST00000288642_length(amino acids)=299AA_BP=
MSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHC
ARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTL
LAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEAEARESAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGV

--------------------------------------------------------------

>91693_91693_20_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000542946_DTNB_chr2_25754467_ENST00000404103_length(amino acids)=299AA_BP=
MSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHC
ARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTL
LAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGV

--------------------------------------------------------------

>91693_91693_21_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000542946_DTNB_chr2_25754467_ENST00000405222_length(amino acids)=262AA_BP=
MSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKSVLDSPSRLDEEHRLIARYAARLAAEAGN
VTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMV

--------------------------------------------------------------

>91693_91693_22_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000542946_DTNB_chr2_25754467_ENST00000406818_length(amino acids)=329AA_BP=
MSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHC
ARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTL
LAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGV

--------------------------------------------------------------

>91693_91693_23_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000542946_DTNB_chr2_25754467_ENST00000407038_length(amino acids)=269AA_BP=
MSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKSVLDSPSRLDEEHRLIARYAARLAAEAGN
VTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMV

--------------------------------------------------------------

>91693_91693_24_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000542946_DTNB_chr2_25754467_ENST00000407186_length(amino acids)=292AA_BP=
MSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKSVLDSPSRLDEEHRLIARYAARLAAEAGN
VTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMV
QLEELMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGVGGDVQEAFAQGTRRNLRNDLLVAADSITNTMSSLVKE

--------------------------------------------------------------

>91693_91693_25_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000542946_DTNB_chr2_25754467_ENST00000407661_length(amino acids)=311AA_BP=
MSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHC
ARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTL
LAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGV

--------------------------------------------------------------

>91693_91693_26_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000542946_DTNB_chr2_25754467_ENST00000496972_length(amino acids)=304AA_BP=
MSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHC
ARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTL
LAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGVGGDVQEA

--------------------------------------------------------------

>91693_91693_27_TMEM138-DTNB_TMEM138_chr11_61133688_ENST00000542946_DTNB_chr2_25754467_ENST00000545439_length(amino acids)=322AA_BP=
MSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHC
ARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTL
LAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGVGGDVQEA

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:61133688/chr2:25754467)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DTNB Q96EV8
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway. {ECO:0000269\|PubMed:15345706, ECO:0000269\|PubMed:16837549, ECO:0000269\|PubMed:17182842, ECO:0000269\|PubMed:17989303, ECO:0000269\|PubMed:19094965, ECO:0000269\|PubMed:20180862, ECO:0000269\|PubMed:20921223}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM138

chr11:61133688

chr2:25754467

ENST00000278826

41_61

100.0

163.0

Transmembrane

Helical

Hgene

TMEM138

chr11:61133688

chr2:25754467

ENST00000278826

7_27

100.0

163.0

Transmembrane

Helical

Hgene

TMEM138

chr11:61133688

chr2:25754467

ENST00000278826

80_100

100.0

163.0

Transmembrane

Helical

Tgene

DTNB

chr11:61133688

chr2:25754467

ENST00000404103

428_529

292.0

607.3333333333334

Coiled coil

Ontology_term=ECO:0000255

Tgene

DTNB

chr11:61133688

chr2:25754467

ENST00000405222

428_529

292.0

570.3333333333334

Coiled coil

Ontology_term=ECO:0000255

Tgene

DTNB

chr11:61133688

chr2:25754467

ENST00000406818

428_529

292.0

637.3333333333334

Coiled coil

Ontology_term=ECO:0000255

Tgene

DTNB

chr11:61133688

chr2:25754467

ENST00000407038

428_529

292.0

577.3333333333334

Coiled coil

Ontology_term=ECO:0000255

Tgene

DTNB

chr11:61133688

chr2:25754467

ENST00000407661

428_529

292.0

619.3333333333334

Coiled coil

Ontology_term=ECO:0000255

Tgene

DTNB

chr11:61133688

chr2:25754467

ENST00000496972

428_529

235.0

581.3333333333334

Coiled coil

Ontology_term=ECO:0000255

Tgene

DTNB

chr11:61133688

chr2:25754467

ENST00000404103

399_448

292.0

607.3333333333334

Region

Note=Syntrophin-binding region

Tgene

DTNB

chr11:61133688

chr2:25754467

ENST00000405222

399_448

292.0

570.3333333333334

Region

Note=Syntrophin-binding region

Tgene

DTNB

chr11:61133688

chr2:25754467

ENST00000406818

399_448

292.0

637.3333333333334

Region

Note=Syntrophin-binding region

Tgene

DTNB

chr11:61133688

chr2:25754467

ENST00000407038

399_448

292.0

577.3333333333334

Region

Note=Syntrophin-binding region

Tgene

DTNB

chr11:61133688

chr2:25754467

ENST00000407661

399_448

292.0

619.3333333333334

Region

Note=Syntrophin-binding region

Tgene

DTNB

chr11:61133688

chr2:25754467

ENST00000496972

399_448

235.0

581.3333333333334

Region

Note=Syntrophin-binding region

Tgene

DTNB

chr11:61133688

chr2:25754467

ENST00000496972

237_284

235.0

581.3333333333334

Zinc finger

ZZ-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM138

chr11:61133688

chr2:25754467

ENST00000278826

110_130

100.0

163.0

Transmembrane

Helical

Hgene

TMEM138

chr11:61133688

chr2:25754467

ENST00000542946

110_130

106.0

Transmembrane

Helical

Hgene

TMEM138

chr11:61133688

chr2:25754467

ENST00000542946

41_61

106.0

Transmembrane

Helical

Hgene

TMEM138

chr11:61133688

chr2:25754467

ENST00000542946

7_27

106.0

Transmembrane

Helical

Hgene

TMEM138

chr11:61133688

chr2:25754467

ENST00000542946

80_100

106.0

Transmembrane

Helical

Tgene

DTNB

chr11:61133688

chr2:25754467

ENST00000404103

237_284

292.0

607.3333333333334

Zinc finger

ZZ-type

Tgene

DTNB

chr11:61133688

chr2:25754467

ENST00000405222

237_284

292.0

570.3333333333334

Zinc finger

ZZ-type

Tgene

DTNB

chr11:61133688

chr2:25754467

ENST00000406818

237_284

292.0

637.3333333333334

Zinc finger

ZZ-type

Tgene

DTNB

chr11:61133688

chr2:25754467

ENST00000407038

237_284

292.0

577.3333333333334

Zinc finger

ZZ-type

Tgene

DTNB

chr11:61133688

chr2:25754467

ENST00000407661

237_284

292.0

619.3333333333334

Zinc finger

ZZ-type

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>939_TMEM138_61133688_DTNB_25754467_939_TMEM138_61133688_DTNB_25754467_ranked_0.pdb	TMEM138	61133688	61133688	ENST00000545439	DTNB	chr2	25754467	-	MWDVPLGARENRRKMLQTSNYSLVLSLQFLLLSYDLFVNSFSELLQKTPVIQLVLFIIQDIAVLFNIIIIFLMFFNTFVFQAGLVNLLFH KFKGTIILTAVYFALSISLHVWVMKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPT KRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNR EILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTH	449

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

TMEM138_pLDDT.png

DTNB_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TMEM138
DTNB

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to TMEM138-DTNB

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to TMEM138-DTNB

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source