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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TMEM165-DACH1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TMEM165-DACH1
	FusionPDB ID: 91755
	FusionGDB2.0 ID: 91755
		Hgene	Tgene
	Gene symbol	TMEM165	DACH1
	Gene ID	55858	1602
	Gene name	transmembrane protein 165	dachshund family transcription factor 1
	Synonyms	CDG2K\|FT27\|GDT1\|TMPT27\|TPARL	DACH
	Cytomap	4q12	13q21.33
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protein 165TPA regulated locustransmembrane protein PT27transmembrane protein TPARL	dachshund homolog 1dac homolog
	Modification date	20200313	20200328
	UniProtAcc	.	Q9UI36
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000514904, ENST00000381334, ENST00000506198, ENST00000542052,	ENST00000305425, ENST00000313174, ENST00000354591, ENST00000359684,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 4 X 6=168	5 X 5 X 3=75
	# samples	9	5
	** MAII score	log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TMEM165 [Title/Abstract] AND DACH1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TMEM165(56290810)-DACH1(72063280), # samples:2
Anticipated loss of major functional domain due to fusion event.	TMEM165-DACH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TMEM165-DACH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TMEM165-DACH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TMEM165-DACH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TMEM165	GO:0032472	Golgi calcium ion transport	23569283
Tgene	DACH1	GO:0000122	negative regulation of transcription by RNA polymerase II	20956529
Tgene	DACH1	GO:0030336	negative regulation of cell migration	20956529
Tgene	DACH1	GO:2000279	negative regulation of DNA biosynthetic process	16980615

Fusion gene breakpoints across TMEM165 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DACH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-29-1778-01A	TMEM165	chr4	56290810	+	DACH1	chr13	72063280	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000506198	TMEM165	chr4	56290810	+	ENST00000313174	DACH1	chr13	72063280	-	3786	546	158	1096	312
ENST00000506198	TMEM165	chr4	56290810	+	ENST00000305425	DACH1	chr13	72063280	-	3786	546	158	1096	312
ENST00000506198	TMEM165	chr4	56290810	+	ENST00000354591	DACH1	chr13	72063280	-	3786	546	158	1096	312
ENST00000506198	TMEM165	chr4	56290810	+	ENST00000359684	DACH1	chr13	72063280	-	1806	546	158	1096	312
ENST00000381334	TMEM165	chr4	56290810	+	ENST00000313174	DACH1	chr13	72063280	-	4371	1131	158	1681	507
ENST00000381334	TMEM165	chr4	56290810	+	ENST00000305425	DACH1	chr13	72063280	-	4371	1131	158	1681	507
ENST00000381334	TMEM165	chr4	56290810	+	ENST00000354591	DACH1	chr13	72063280	-	4371	1131	158	1681	507
ENST00000381334	TMEM165	chr4	56290810	+	ENST00000359684	DACH1	chr13	72063280	-	2391	1131	158	1681	507
ENST00000542052	TMEM165	chr4	56290810	+	ENST00000313174	DACH1	chr13	72063280	-	4468	1228	519	1778	419
ENST00000542052	TMEM165	chr4	56290810	+	ENST00000305425	DACH1	chr13	72063280	-	4468	1228	519	1778	419
ENST00000542052	TMEM165	chr4	56290810	+	ENST00000354591	DACH1	chr13	72063280	-	4468	1228	519	1778	419
ENST00000542052	TMEM165	chr4	56290810	+	ENST00000359684	DACH1	chr13	72063280	-	2488	1228	519	1778	419

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000506198	ENST00000313174	TMEM165	chr4	56290810	+	DACH1	chr13	72063280	-	0.00034091	0.99965906
ENST00000506198	ENST00000305425	TMEM165	chr4	56290810	+	DACH1	chr13	72063280	-	0.00034091	0.99965906
ENST00000506198	ENST00000354591	TMEM165	chr4	56290810	+	DACH1	chr13	72063280	-	0.00034091	0.99965906
ENST00000506198	ENST00000359684	TMEM165	chr4	56290810	+	DACH1	chr13	72063280	-	0.001707521	0.9982925
ENST00000381334	ENST00000313174	TMEM165	chr4	56290810	+	DACH1	chr13	72063280	-	0.000264896	0.99973506
ENST00000381334	ENST00000305425	TMEM165	chr4	56290810	+	DACH1	chr13	72063280	-	0.000264896	0.99973506
ENST00000381334	ENST00000354591	TMEM165	chr4	56290810	+	DACH1	chr13	72063280	-	0.000264896	0.99973506
ENST00000381334	ENST00000359684	TMEM165	chr4	56290810	+	DACH1	chr13	72063280	-	0.001714085	0.99828595
ENST00000542052	ENST00000313174	TMEM165	chr4	56290810	+	DACH1	chr13	72063280	-	0.000272862	0.9997271
ENST00000542052	ENST00000305425	TMEM165	chr4	56290810	+	DACH1	chr13	72063280	-	0.000272862	0.9997271
ENST00000542052	ENST00000354591	TMEM165	chr4	56290810	+	DACH1	chr13	72063280	-	0.000272862	0.9997271
ENST00000542052	ENST00000359684	TMEM165	chr4	56290810	+	DACH1	chr13	72063280	-	0.001689954	0.9983101

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>91755_91755_1_TMEM165-DACH1_TMEM165_chr4_56290810_ENST00000381334_DACH1_chr13_72063280_ENST00000305425_length(amino acids)=507AA_BP=324
MFGVEASRRRHFLLRRPCAAGPAGGMAAAAPGNGRASAPRLLLLFLVPLLWAPAAVRAGPDEDLSHRNKEPPAPAQQLQPQPVAVQGPEP
ARVEKIFTPAAPVHTNKEDPATQTNLGFIHAFVAAISVIIVSELGDKTFFIAAIMAMRYNRLTVLAGAMLALGLMTCLSVLFGYATTVIP
RVYTYYVSTVLFAIFGIRMLREGLKMSPDEGQEELEEVQAELKKKDEEFQRTKLLNGPGDVETGTSITVPQKKWLHFISPIFVQALTLTF
LAEWGDRSQLTTIVLAAREDPYGVAVGGTVGHCLCTGLAVIGGRMIAQKISVRTDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPFLF
PDGLSSIETLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFETK

--------------------------------------------------------------

>91755_91755_2_TMEM165-DACH1_TMEM165_chr4_56290810_ENST00000381334_DACH1_chr13_72063280_ENST00000313174_length(amino acids)=507AA_BP=324
MFGVEASRRRHFLLRRPCAAGPAGGMAAAAPGNGRASAPRLLLLFLVPLLWAPAAVRAGPDEDLSHRNKEPPAPAQQLQPQPVAVQGPEP
ARVEKIFTPAAPVHTNKEDPATQTNLGFIHAFVAAISVIIVSELGDKTFFIAAIMAMRYNRLTVLAGAMLALGLMTCLSVLFGYATTVIP
RVYTYYVSTVLFAIFGIRMLREGLKMSPDEGQEELEEVQAELKKKDEEFQRTKLLNGPGDVETGTSITVPQKKWLHFISPIFVQALTLTF
LAEWGDRSQLTTIVLAAREDPYGVAVGGTVGHCLCTGLAVIGGRMIAQKISVRTDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPFLF
PDGLSSIETLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFETK

--------------------------------------------------------------

>91755_91755_3_TMEM165-DACH1_TMEM165_chr4_56290810_ENST00000381334_DACH1_chr13_72063280_ENST00000354591_length(amino acids)=507AA_BP=324
MFGVEASRRRHFLLRRPCAAGPAGGMAAAAPGNGRASAPRLLLLFLVPLLWAPAAVRAGPDEDLSHRNKEPPAPAQQLQPQPVAVQGPEP
ARVEKIFTPAAPVHTNKEDPATQTNLGFIHAFVAAISVIIVSELGDKTFFIAAIMAMRYNRLTVLAGAMLALGLMTCLSVLFGYATTVIP
RVYTYYVSTVLFAIFGIRMLREGLKMSPDEGQEELEEVQAELKKKDEEFQRTKLLNGPGDVETGTSITVPQKKWLHFISPIFVQALTLTF
LAEWGDRSQLTTIVLAAREDPYGVAVGGTVGHCLCTGLAVIGGRMIAQKISVRTDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPFLF
PDGLSSIETLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFETK

--------------------------------------------------------------

>91755_91755_4_TMEM165-DACH1_TMEM165_chr4_56290810_ENST00000381334_DACH1_chr13_72063280_ENST00000359684_length(amino acids)=507AA_BP=324
MFGVEASRRRHFLLRRPCAAGPAGGMAAAAPGNGRASAPRLLLLFLVPLLWAPAAVRAGPDEDLSHRNKEPPAPAQQLQPQPVAVQGPEP
ARVEKIFTPAAPVHTNKEDPATQTNLGFIHAFVAAISVIIVSELGDKTFFIAAIMAMRYNRLTVLAGAMLALGLMTCLSVLFGYATTVIP
RVYTYYVSTVLFAIFGIRMLREGLKMSPDEGQEELEEVQAELKKKDEEFQRTKLLNGPGDVETGTSITVPQKKWLHFISPIFVQALTLTF
LAEWGDRSQLTTIVLAAREDPYGVAVGGTVGHCLCTGLAVIGGRMIAQKISVRTDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPFLF
PDGLSSIETLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFETK

--------------------------------------------------------------

>91755_91755_5_TMEM165-DACH1_TMEM165_chr4_56290810_ENST00000506198_DACH1_chr13_72063280_ENST00000305425_length(amino acids)=312AA_BP=129
MFGVEASRRRHFLLRRPCAAGPAGGMAAAAPGNGRASAPRLLLLFLVPLLWAPAAVRAGPDEDLSHRNKEPPAPAQQLQPQPVAVQGPEP
ARVEDPYGVAVGGTVGHCLCTGLAVIGGRMIAQKISVRTDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPFLFPDGLSSIETLLTNIQ
GLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFETKRREQAEQTLKQAAST

--------------------------------------------------------------

>91755_91755_6_TMEM165-DACH1_TMEM165_chr4_56290810_ENST00000506198_DACH1_chr13_72063280_ENST00000313174_length(amino acids)=312AA_BP=129
MFGVEASRRRHFLLRRPCAAGPAGGMAAAAPGNGRASAPRLLLLFLVPLLWAPAAVRAGPDEDLSHRNKEPPAPAQQLQPQPVAVQGPEP
ARVEDPYGVAVGGTVGHCLCTGLAVIGGRMIAQKISVRTDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPFLFPDGLSSIETLLTNIQ
GLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFETKRREQAEQTLKQAAST

--------------------------------------------------------------

>91755_91755_7_TMEM165-DACH1_TMEM165_chr4_56290810_ENST00000506198_DACH1_chr13_72063280_ENST00000354591_length(amino acids)=312AA_BP=129
MFGVEASRRRHFLLRRPCAAGPAGGMAAAAPGNGRASAPRLLLLFLVPLLWAPAAVRAGPDEDLSHRNKEPPAPAQQLQPQPVAVQGPEP
ARVEDPYGVAVGGTVGHCLCTGLAVIGGRMIAQKISVRTDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPFLFPDGLSSIETLLTNIQ
GLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFETKRREQAEQTLKQAAST

--------------------------------------------------------------

>91755_91755_8_TMEM165-DACH1_TMEM165_chr4_56290810_ENST00000506198_DACH1_chr13_72063280_ENST00000359684_length(amino acids)=312AA_BP=129
MFGVEASRRRHFLLRRPCAAGPAGGMAAAAPGNGRASAPRLLLLFLVPLLWAPAAVRAGPDEDLSHRNKEPPAPAQQLQPQPVAVQGPEP
ARVEDPYGVAVGGTVGHCLCTGLAVIGGRMIAQKISVRTDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPFLFPDGLSSIETLLTNIQ
GLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFETKRREQAEQTLKQAAST

--------------------------------------------------------------

>91755_91755_9_TMEM165-DACH1_TMEM165_chr4_56290810_ENST00000542052_DACH1_chr13_72063280_ENST00000305425_length(amino acids)=419AA_BP=236
MEIPMQKIFTPAAPVHTNKEDPATQTNLGFIHAFVAAISVIIVSELGDKTFFIAAIMAMRYNRLTVLAGAMLALGLMTCLSVLFGYATTV
IPRVYTYYVSTVLFAIFGIRMLREGLKMSPDEGQEELEEVQAELKKKDEEFQRTKLLNGPGDVETGTSITVPQKKWLHFISPIFVQALTL
TFLAEWGDRSQLTTIVLAAREDPYGVAVGGTVGHCLCTGLAVIGGRMIAQKISVRTDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPF
LFPDGLSSIETLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFE

--------------------------------------------------------------

>91755_91755_10_TMEM165-DACH1_TMEM165_chr4_56290810_ENST00000542052_DACH1_chr13_72063280_ENST00000313174_length(amino acids)=419AA_BP=236
MEIPMQKIFTPAAPVHTNKEDPATQTNLGFIHAFVAAISVIIVSELGDKTFFIAAIMAMRYNRLTVLAGAMLALGLMTCLSVLFGYATTV
IPRVYTYYVSTVLFAIFGIRMLREGLKMSPDEGQEELEEVQAELKKKDEEFQRTKLLNGPGDVETGTSITVPQKKWLHFISPIFVQALTL
TFLAEWGDRSQLTTIVLAAREDPYGVAVGGTVGHCLCTGLAVIGGRMIAQKISVRTDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPF
LFPDGLSSIETLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFE

--------------------------------------------------------------

>91755_91755_11_TMEM165-DACH1_TMEM165_chr4_56290810_ENST00000542052_DACH1_chr13_72063280_ENST00000354591_length(amino acids)=419AA_BP=236
MEIPMQKIFTPAAPVHTNKEDPATQTNLGFIHAFVAAISVIIVSELGDKTFFIAAIMAMRYNRLTVLAGAMLALGLMTCLSVLFGYATTV
IPRVYTYYVSTVLFAIFGIRMLREGLKMSPDEGQEELEEVQAELKKKDEEFQRTKLLNGPGDVETGTSITVPQKKWLHFISPIFVQALTL
TFLAEWGDRSQLTTIVLAAREDPYGVAVGGTVGHCLCTGLAVIGGRMIAQKISVRTDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPF
LFPDGLSSIETLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFE

--------------------------------------------------------------

>91755_91755_12_TMEM165-DACH1_TMEM165_chr4_56290810_ENST00000542052_DACH1_chr13_72063280_ENST00000359684_length(amino acids)=419AA_BP=236
MEIPMQKIFTPAAPVHTNKEDPATQTNLGFIHAFVAAISVIIVSELGDKTFFIAAIMAMRYNRLTVLAGAMLALGLMTCLSVLFGYATTV
IPRVYTYYVSTVLFAIFGIRMLREGLKMSPDEGQEELEEVQAELKKKDEEFQRTKLLNGPGDVETGTSITVPQKKWLHFISPIFVQALTL
TFLAEWGDRSQLTTIVLAAREDPYGVAVGGTVGHCLCTGLAVIGGRMIAQKISVRTDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPF
LFPDGLSSIETLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRAIVQKRLKKEKKAKRKLQEALEFE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:56290810/chr13:72063280)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DACH1 Q9UI36
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity). {ECO:0000250, ECO:0000269\|PubMed:14525983}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM165

chr4:56290810

chr13:72063280

ENST00000381334

184_211

299.3333333333333

325.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

TMEM165

chr4:56290810

chr13:72063280

ENST00000381334

111_126

299.3333333333333

325.0

Topological domain

Cytoplasmic

Hgene

TMEM165

chr4:56290810

chr13:72063280

ENST00000381334

148_151

299.3333333333333

325.0

Topological domain

Lumenal

Hgene

TMEM165

chr4:56290810

chr13:72063280

ENST00000381334

173_228

299.3333333333333

325.0

Topological domain

Cytoplasmic

Hgene

TMEM165

chr4:56290810

chr13:72063280

ENST00000381334

250_267

299.3333333333333

325.0

Topological domain

Lumenal

Hgene

TMEM165

chr4:56290810

chr13:72063280

ENST00000381334

289_299

299.3333333333333

325.0

Topological domain

Cytoplasmic

Hgene

TMEM165

chr4:56290810

chr13:72063280

ENST00000381334

34_89

299.3333333333333

325.0

Topological domain

Lumenal

Hgene

TMEM165

chr4:56290810

chr13:72063280

ENST00000381334

127_147

299.3333333333333

325.0

Transmembrane

Helical

Hgene

TMEM165

chr4:56290810

chr13:72063280

ENST00000381334

152_172

299.3333333333333

325.0

Transmembrane

Helical

Hgene

TMEM165

chr4:56290810

chr13:72063280

ENST00000381334

229_249

299.3333333333333

325.0

Transmembrane

Helical

Hgene

TMEM165

chr4:56290810

chr13:72063280

ENST00000381334

268_288

299.3333333333333

325.0

Transmembrane

Helical

Hgene

TMEM165

chr4:56290810

chr13:72063280

ENST00000381334

90_110

299.3333333333333

325.0

Transmembrane

Helical

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000305425

630_718

525.3333333333334

709.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000313174

630_718

377.3333333333333

561.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000354591

630_718

323.3333333333333

507.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000359684

630_718

577.3333333333334

761.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000313174

467_470

377.3333333333333

561.0

Compositional bias

Note=Poly-Ala

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000354591

325_333

323.3333333333333

507.0

Compositional bias

Note=Poly-Ala

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000354591

467_470

323.3333333333333

507.0

Compositional bias

Note=Poly-Ala

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000305425

616_696

525.3333333333334

709.0

Region

Note=DACHbox-C

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000313174

616_696

377.3333333333333

561.0

Region

Note=DACHbox-C

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000354591

616_696

323.3333333333333

507.0

Region

Note=DACHbox-C

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000359684

616_696

577.3333333333334

761.0

Region

Note=DACHbox-C

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM165

chr4:56290810

chr13:72063280

ENST00000381334

321_324

299.3333333333333

325.0

Topological domain

Lumenal

Hgene

TMEM165

chr4:56290810

chr13:72063280

ENST00000381334

300_320

299.3333333333333

325.0

Transmembrane

Helical

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000305425

114_121

525.3333333333334

709.0

Compositional bias

Note=Poly-Gly

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000305425

140_163

525.3333333333334

709.0

Compositional bias

Note=Poly-Ser

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000305425

325_333

525.3333333333334

709.0

Compositional bias

Note=Poly-Ala

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000305425

467_470

525.3333333333334

709.0

Compositional bias

Note=Poly-Ala

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000305425

61_68

525.3333333333334

709.0

Compositional bias

Note=Poly-Ala

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000305425

74_87

525.3333333333334

709.0

Compositional bias

Note=Poly-Gly

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000305425

90_101

525.3333333333334

709.0

Compositional bias

Note=Poly-Gly

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000313174

114_121

377.3333333333333

561.0

Compositional bias

Note=Poly-Gly

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000313174

140_163

377.3333333333333

561.0

Compositional bias

Note=Poly-Ser

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000313174

325_333

377.3333333333333

561.0

Compositional bias

Note=Poly-Ala

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000313174

61_68

377.3333333333333

561.0

Compositional bias

Note=Poly-Ala

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000313174

74_87

377.3333333333333

561.0

Compositional bias

Note=Poly-Gly

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000313174

90_101

377.3333333333333

561.0

Compositional bias

Note=Poly-Gly

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000354591

114_121

323.3333333333333

507.0

Compositional bias

Note=Poly-Gly

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000354591

140_163

323.3333333333333

507.0

Compositional bias

Note=Poly-Ser

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000354591

61_68

323.3333333333333

507.0

Compositional bias

Note=Poly-Ala

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000354591

74_87

323.3333333333333

507.0

Compositional bias

Note=Poly-Gly

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000354591

90_101

323.3333333333333

507.0

Compositional bias

Note=Poly-Gly

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000359684

114_121

577.3333333333334

761.0

Compositional bias

Note=Poly-Gly

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000359684

140_163

577.3333333333334

761.0

Compositional bias

Note=Poly-Ser

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000359684

325_333

577.3333333333334

761.0

Compositional bias

Note=Poly-Ala

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000359684

467_470

577.3333333333334

761.0

Compositional bias

Note=Poly-Ala

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000359684

61_68

577.3333333333334

761.0

Compositional bias

Note=Poly-Ala

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000359684

74_87

577.3333333333334

761.0

Compositional bias

Note=Poly-Gly

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000359684

90_101

577.3333333333334

761.0

Compositional bias

Note=Poly-Gly

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000305425

189_275

525.3333333333334

709.0

Region

Note=DACHbox-N

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000313174

189_275

377.3333333333333

561.0

Region

Note=DACHbox-N

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000354591

189_275

323.3333333333333

507.0

Region

Note=DACHbox-N

Tgene

DACH1

chr4:56290810

chr13:72063280

ENST00000359684

189_275

577.3333333333334

761.0

Region

Note=DACHbox-N

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TMEM165
DACH1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	DACH1	chr4:56290810	chr13:72063280	ENST00000305425		5	11	189_384	525.3333333333334	709.0	SIX6 and HDAC3
Tgene	DACH1	chr4:56290810	chr13:72063280	ENST00000313174		2	8	189_384	377.3333333333333	561.0	SIX6 and HDAC3
Tgene	DACH1	chr4:56290810	chr13:72063280	ENST00000354591		1	7	189_384	323.3333333333333	507.0	SIX6 and HDAC3
Tgene	DACH1	chr4:56290810	chr13:72063280	ENST00000359684		6	12	189_384	577.3333333333334	761.0	SIX6 and HDAC3

Top

Related Drugs to TMEM165-DACH1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to TMEM165-DACH1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source