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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TMPRSS2-BRAF

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TMPRSS2-BRAF
FusionPDB ID: 92369
FusionGDB2.0 ID: 92369
HgeneTgene
Gene symbol

TMPRSS2

BRAF

Gene ID

7113

673

Gene nametransmembrane serine protease 2B-Raf proto-oncogene, serine/threonine kinase
SynonymsPP9284|PRSS10B-RAF1|B-raf|BRAF1|NS7|RAFB1
Cytomap

21q22.3

7q34

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2serine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene
Modification date2020031320200329
UniProtAcc

O15393

P15056

Ensembl transtripts involved in fusion geneENST idsENST00000497881, ENST00000332149, 
ENST00000398585, ENST00000458356, 
ENST00000288602, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score40 X 73 X 10=2920048 X 58 X 16=44544
# samples 13069
** MAII scorelog2(130/29200*10)=-4.48938484073892
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(69/44544*10)=-6.0124909441832
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TMPRSS2 [Title/Abstract] AND BRAF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TMPRSS2(42866283)-BRAF(140481493), # samples:3
Anticipated loss of major functional domain due to fusion event.TMPRSS2-BRAF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-BRAF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-BRAF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-BRAF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-BRAF seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TMPRSS2-BRAF seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TMPRSS2-BRAF seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TMPRSS2-BRAF seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TMPRSS2-BRAF seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

HgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843

TgeneBRAF

GO:0000186

activation of MAPKK activity

29433126

TgeneBRAF

GO:0006468

protein phosphorylation

17563371

TgeneBRAF

GO:0010828

positive regulation of glucose transmembrane transport

23010278

TgeneBRAF

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

TgeneBRAF

GO:0043066

negative regulation of apoptotic process

19667065

TgeneBRAF

GO:0070374

positive regulation of ERK1 and ERK2 cascade

22065586

TgeneBRAF

GO:0071277

cellular response to calcium ion

18567582

TgeneBRAF

GO:0090150

establishment of protein localization to membrane

23010278


check buttonFusion gene breakpoints across TMPRSS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BRAF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-FC-A6HD-01ATMPRSS2chr21

42866282

-BRAFchr7

140481492

-
ChimerDB4PRADTCGA-FC-A6HD-01ATMPRSS2chr21

42866283

-BRAFchr7

140481493

-
ChimerDB4PRADTCGA-FC-A6HD-01ATMPRSS2chr21

42870045

-BRAFchr7

140481492

-
ChimerDB4PRADTCGA-FC-A6HDTMPRSS2chr21

42866282

-BRAFchr7

140481493

-
ChimerDB4PRADTCGA-FC-A6HDTMPRSS2chr21

42866283

-BRAFchr7

140481493

-
ChimerDB4PRADTCGA-FC-A6HDTMPRSS2chr21

42870046

-BRAFchr7

140481493

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000458356TMPRSS2chr2142866283-ENST00000288602BRAFchr7140481493-14323274621313283
ENST00000458356TMPRSS2chr2142866282-ENST00000288602BRAFchr7140481493-14323274621313283
ENST00000332149TMPRSS2chr2142870046-ENST00000288602BRAFchr7140481493-12551501351136333
ENST00000398585TMPRSS2chr2142870046-ENST00000288602BRAFchr7140481493-1292187401173377
ENST00000458356TMPRSS2chr2142866282-ENST00000288602BRAFchr7140481492-14323274621313283
ENST00000332149TMPRSS2chr2142870045-ENST00000288602BRAFchr7140481492-12551501351136333
ENST00000398585TMPRSS2chr2142870045-ENST00000288602BRAFchr7140481492-1292187401173377

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000458356ENST00000288602TMPRSS2chr2142866283-BRAFchr7140481493-0.0013292330.9986708
ENST00000458356ENST00000288602TMPRSS2chr2142866282-BRAFchr7140481493-0.0013292330.9986708
ENST00000332149ENST00000288602TMPRSS2chr2142870046-BRAFchr7140481493-0.0011018050.99889815
ENST00000398585ENST00000288602TMPRSS2chr2142870046-BRAFchr7140481493-0.0013215050.9986785
ENST00000458356ENST00000288602TMPRSS2chr2142866282-BRAFchr7140481492-0.0013292330.9986708
ENST00000332149ENST00000288602TMPRSS2chr2142870045-BRAFchr7140481492-0.0011018050.99889815
ENST00000398585ENST00000288602TMPRSS2chr2142870045-BRAFchr7140481492-0.0013215050.9986785

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>92369_92369_1_TMPRSS2-BRAF_TMPRSS2_chr21_42866282_ENST00000458356_BRAF_chr7_140481492_ENST00000288602_length(amino acids)=283AA_BP=
MLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSII
HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD
QIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKT

--------------------------------------------------------------

>92369_92369_2_TMPRSS2-BRAF_TMPRSS2_chr21_42866282_ENST00000458356_BRAF_chr7_140481493_ENST00000288602_length(amino acids)=283AA_BP=
MLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSII
HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD
QIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKT

--------------------------------------------------------------

>92369_92369_3_TMPRSS2-BRAF_TMPRSS2_chr21_42866283_ENST00000458356_BRAF_chr7_140481493_ENST00000288602_length(amino acids)=283AA_BP=
MLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSII
HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD
QIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKT

--------------------------------------------------------------

>92369_92369_4_TMPRSS2-BRAF_TMPRSS2_chr21_42870045_ENST00000332149_BRAF_chr7_140481492_ENST00000288602_length(amino acids)=333AA_BP=5
MALNSKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP
QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL
SGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDE

--------------------------------------------------------------

>92369_92369_5_TMPRSS2-BRAF_TMPRSS2_chr21_42870045_ENST00000398585_BRAF_chr7_140481492_ENST00000288602_length(amino acids)=377AA_BP=49
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD
VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHA
KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNI
NNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACA

--------------------------------------------------------------

>92369_92369_6_TMPRSS2-BRAF_TMPRSS2_chr21_42870046_ENST00000332149_BRAF_chr7_140481493_ENST00000288602_length(amino acids)=333AA_BP=5
MALNSKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKP
QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQL
SGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDE

--------------------------------------------------------------

>92369_92369_7_TMPRSS2-BRAF_TMPRSS2_chr21_42870046_ENST00000398585_BRAF_chr7_140481493_ENST00000288602_length(amino acids)=377AA_BP=49
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD
VAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHA
KSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNI
NNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:42866283/chr7:140481493)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMPRSS2

O15393

BRAF

P15056

FUNCTION: Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity). {ECO:0000250|UniProtKB:Q9JIQ8, ECO:0000269|PubMed:15537383, ECO:0000269|PubMed:25122198, ECO:0000269|PubMed:26018085}.; FUNCTION: (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436, PubMed:34159616, PubMed:33051876). Upon SARS-CoV-2 infection, increases syncytia formation by accelerating the fusion process (PubMed:34159616, PubMed:33051876). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. {ECO:0000269|PubMed:21068237, ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651, ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32404436, ECO:0000269|PubMed:33051876, ECO:0000269|PubMed:34159616}.FUNCTION: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269|PubMed:1508179, ECO:0000269|PubMed:21441910, ECO:0000269|PubMed:29433126, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42866282chr7:140481492ENST00000398585-3141_84116.33333333333333530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866282chr7:140481493ENST00000398585-3141_84116.33333333333333530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866283chr7:140481493ENST00000398585-3141_84116.33333333333333530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866282chr7:140481492ENST00000398585-31485_105116.33333333333333530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42866282chr7:140481493ENST00000398585-31485_105116.33333333333333530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42866283chr7:140481493ENST00000398585-31485_105116.33333333333333530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneBRAFchr21:42866282chr7:140481492ENST00000288602918457_717438.0767.0DomainProtein kinase
TgeneBRAFchr21:42866282chr7:140481493ENST00000288602918457_717438.0767.0DomainProtein kinase
TgeneBRAFchr21:42866283chr7:140481493ENST00000288602918457_717438.0767.0DomainProtein kinase
TgeneBRAFchr21:42870045chr7:140481492ENST00000288602918457_717438.0767.0DomainProtein kinase
TgeneBRAFchr21:42870046chr7:140481493ENST00000288602918457_717438.0767.0DomainProtein kinase
TgeneBRAFchr21:42866282chr7:140481492ENST00000288602918463_471438.0767.0Nucleotide bindingATP
TgeneBRAFchr21:42866282chr7:140481493ENST00000288602918463_471438.0767.0Nucleotide bindingATP
TgeneBRAFchr21:42866283chr7:140481493ENST00000288602918463_471438.0767.0Nucleotide bindingATP
TgeneBRAFchr21:42870045chr7:140481492ENST00000288602918463_471438.0767.0Nucleotide bindingATP
TgeneBRAFchr21:42870046chr7:140481493ENST00000288602918463_471438.0767.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42866282chr7:140481492ENST00000332149-314112_14979.33333333333333493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866282chr7:140481492ENST00000332149-314150_24279.33333333333333493.0DomainSRCR
HgeneTMPRSS2chr21:42866282chr7:140481492ENST00000332149-314256_48979.33333333333333493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866282chr7:140481492ENST00000398585-314112_149116.33333333333333530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866282chr7:140481492ENST00000398585-314150_242116.33333333333333530.0DomainSRCR
HgeneTMPRSS2chr21:42866282chr7:140481492ENST00000398585-314256_489116.33333333333333530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866282chr7:140481492ENST00000458356-314112_14979.33333333333333493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866282chr7:140481492ENST00000458356-314150_24279.33333333333333493.0DomainSRCR
HgeneTMPRSS2chr21:42866282chr7:140481492ENST00000458356-314256_48979.33333333333333493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866282chr7:140481493ENST00000332149-314112_14979.33333333333333493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866282chr7:140481493ENST00000332149-314150_24279.33333333333333493.0DomainSRCR
HgeneTMPRSS2chr21:42866282chr7:140481493ENST00000332149-314256_48979.33333333333333493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866282chr7:140481493ENST00000398585-314112_149116.33333333333333530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866282chr7:140481493ENST00000398585-314150_242116.33333333333333530.0DomainSRCR
HgeneTMPRSS2chr21:42866282chr7:140481493ENST00000398585-314256_489116.33333333333333530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866282chr7:140481493ENST00000458356-314112_14979.33333333333333493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866282chr7:140481493ENST00000458356-314150_24279.33333333333333493.0DomainSRCR
HgeneTMPRSS2chr21:42866282chr7:140481493ENST00000458356-314256_48979.33333333333333493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866283chr7:140481493ENST00000332149-314112_14979.33333333333333493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866283chr7:140481493ENST00000332149-314150_24279.33333333333333493.0DomainSRCR
HgeneTMPRSS2chr21:42866283chr7:140481493ENST00000332149-314256_48979.33333333333333493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866283chr7:140481493ENST00000398585-314112_149116.33333333333333530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866283chr7:140481493ENST00000398585-314150_242116.33333333333333530.0DomainSRCR
HgeneTMPRSS2chr21:42866283chr7:140481493ENST00000398585-314256_489116.33333333333333530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866283chr7:140481493ENST00000458356-314112_14979.33333333333333493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866283chr7:140481493ENST00000458356-314150_24279.33333333333333493.0DomainSRCR
HgeneTMPRSS2chr21:42866283chr7:140481493ENST00000458356-314256_48979.33333333333333493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870045chr7:140481492ENST00000332149-214112_1495.0493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870045chr7:140481492ENST00000332149-214150_2425.0493.0DomainSRCR
HgeneTMPRSS2chr21:42870045chr7:140481492ENST00000332149-214256_4895.0493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870045chr7:140481492ENST00000398585-214112_14942.0530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870045chr7:140481492ENST00000398585-214150_24242.0530.0DomainSRCR
HgeneTMPRSS2chr21:42870045chr7:140481492ENST00000398585-214256_48942.0530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870045chr7:140481492ENST00000458356-214112_1495.0493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870045chr7:140481492ENST00000458356-214150_2425.0493.0DomainSRCR
HgeneTMPRSS2chr21:42870045chr7:140481492ENST00000458356-214256_4895.0493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870046chr7:140481493ENST00000332149-214112_1495.0493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870046chr7:140481493ENST00000332149-214150_2425.0493.0DomainSRCR
HgeneTMPRSS2chr21:42870046chr7:140481493ENST00000332149-214256_4895.0493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870046chr7:140481493ENST00000398585-214112_14942.0530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870046chr7:140481493ENST00000398585-214150_24242.0530.0DomainSRCR
HgeneTMPRSS2chr21:42870046chr7:140481493ENST00000398585-214256_48942.0530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870046chr7:140481493ENST00000458356-214112_1495.0493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870046chr7:140481493ENST00000458356-214150_2425.0493.0DomainSRCR
HgeneTMPRSS2chr21:42870046chr7:140481493ENST00000458356-214256_4895.0493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866282chr7:140481492ENST00000332149-314106_49279.33333333333333493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866282chr7:140481492ENST00000332149-3141_8479.33333333333333493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866282chr7:140481492ENST00000398585-314106_492116.33333333333333530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866282chr7:140481492ENST00000458356-314106_49279.33333333333333493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866282chr7:140481492ENST00000458356-3141_8479.33333333333333493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866282chr7:140481493ENST00000332149-314106_49279.33333333333333493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866282chr7:140481493ENST00000332149-3141_8479.33333333333333493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866282chr7:140481493ENST00000398585-314106_492116.33333333333333530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866282chr7:140481493ENST00000458356-314106_49279.33333333333333493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866282chr7:140481493ENST00000458356-3141_8479.33333333333333493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866283chr7:140481493ENST00000332149-314106_49279.33333333333333493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866283chr7:140481493ENST00000332149-3141_8479.33333333333333493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866283chr7:140481493ENST00000398585-314106_492116.33333333333333530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866283chr7:140481493ENST00000458356-314106_49279.33333333333333493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866283chr7:140481493ENST00000458356-3141_8479.33333333333333493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870045chr7:140481492ENST00000332149-214106_4925.0493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870045chr7:140481492ENST00000332149-2141_845.0493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870045chr7:140481492ENST00000398585-214106_49242.0530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870045chr7:140481492ENST00000398585-2141_8442.0530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870045chr7:140481492ENST00000458356-214106_4925.0493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870045chr7:140481492ENST00000458356-2141_845.0493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870046chr7:140481493ENST00000332149-214106_4925.0493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870046chr7:140481493ENST00000332149-2141_845.0493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870046chr7:140481493ENST00000398585-214106_49242.0530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870046chr7:140481493ENST00000398585-2141_8442.0530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870046chr7:140481493ENST00000458356-214106_4925.0493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870046chr7:140481493ENST00000458356-2141_845.0493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866282chr7:140481492ENST00000332149-31485_10579.33333333333333493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42866282chr7:140481492ENST00000458356-31485_10579.33333333333333493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42866282chr7:140481493ENST00000332149-31485_10579.33333333333333493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42866282chr7:140481493ENST00000458356-31485_10579.33333333333333493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42866283chr7:140481493ENST00000332149-31485_10579.33333333333333493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42866283chr7:140481493ENST00000458356-31485_10579.33333333333333493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870045chr7:140481492ENST00000332149-21485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870045chr7:140481492ENST00000398585-21485_10542.0530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870045chr7:140481492ENST00000458356-21485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870046chr7:140481493ENST00000332149-21485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870046chr7:140481493ENST00000398585-21485_10542.0530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870046chr7:140481493ENST00000458356-21485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneBRAFchr21:42866282chr7:140481492ENST00000288602918122_129438.0767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr21:42866282chr7:140481492ENST00000288602918428_432438.0767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr21:42866282chr7:140481492ENST000002886029186_11438.0767.0Compositional biasNote=Poly-Gly
TgeneBRAFchr21:42866282chr7:140481493ENST00000288602918122_129438.0767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr21:42866282chr7:140481493ENST00000288602918428_432438.0767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr21:42866282chr7:140481493ENST000002886029186_11438.0767.0Compositional biasNote=Poly-Gly
TgeneBRAFchr21:42866283chr7:140481493ENST00000288602918122_129438.0767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr21:42866283chr7:140481493ENST00000288602918428_432438.0767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr21:42866283chr7:140481493ENST000002886029186_11438.0767.0Compositional biasNote=Poly-Gly
TgeneBRAFchr21:42870045chr7:140481492ENST00000288602918122_129438.0767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr21:42870045chr7:140481492ENST00000288602918428_432438.0767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr21:42870045chr7:140481492ENST000002886029186_11438.0767.0Compositional biasNote=Poly-Gly
TgeneBRAFchr21:42870046chr7:140481493ENST00000288602918122_129438.0767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr21:42870046chr7:140481493ENST00000288602918428_432438.0767.0Compositional biasNote=Poly-Ser
TgeneBRAFchr21:42870046chr7:140481493ENST000002886029186_11438.0767.0Compositional biasNote=Poly-Gly
TgeneBRAFchr21:42866282chr7:140481492ENST00000288602918155_227438.0767.0DomainRBD
TgeneBRAFchr21:42866282chr7:140481493ENST00000288602918155_227438.0767.0DomainRBD
TgeneBRAFchr21:42866283chr7:140481493ENST00000288602918155_227438.0767.0DomainRBD
TgeneBRAFchr21:42870045chr7:140481492ENST00000288602918155_227438.0767.0DomainRBD
TgeneBRAFchr21:42870046chr7:140481493ENST00000288602918155_227438.0767.0DomainRBD
TgeneBRAFchr21:42866282chr7:140481492ENST00000288602918234_280438.0767.0Zinc fingerPhorbol-ester/DAG-type
TgeneBRAFchr21:42866282chr7:140481493ENST00000288602918234_280438.0767.0Zinc fingerPhorbol-ester/DAG-type
TgeneBRAFchr21:42866283chr7:140481493ENST00000288602918234_280438.0767.0Zinc fingerPhorbol-ester/DAG-type
TgeneBRAFchr21:42870045chr7:140481492ENST00000288602918234_280438.0767.0Zinc fingerPhorbol-ester/DAG-type
TgeneBRAFchr21:42870046chr7:140481493ENST00000288602918234_280438.0767.0Zinc fingerPhorbol-ester/DAG-type


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>493_TMPRSS2_42866283_BRAF_140481493_ranked_0.pdbTMPRSS24287004542866283ENST00000288602BRAFchr7140481493-
MLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSII
HRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRD
QIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKT
283


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
TMPRSS2_pLDDT.png
all structure
all structure
BRAF_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
BRAFYWHAB, YWHAG, YWHAQ, YWHAZ, SFN, HRAS, AKT1, MAPK3, RAP1GAP, RAF1, MRAS, RAP1A, PAK2, TERF1, CCDC88A, NEDD4L, Nedd4, MAP2K1, RNF149, KSR1, BRAP, PRKCE, RPS6KB2, HSP90AA1, BRAF, YWHAE, HSPA5, MAP2K2, HSPA1A, HSPA8, YWHAH, HSPA9, ARAF, CDC37, HSP90AB1, PHKB, LIMK1, IQGAP1, MAPK1, BAD, LIPF, MUS81, Vps4b, FBXW7, FGFR2, BRCA2, VHL, FNTA, HDAC2, PIK3CA, EGFR, PTEN, FNIP1, FNIP2, RAB3GAP1, KRAS, KIAA0141, FKBPL, ARMCX3, KCNC4, RPTOR, CYLD, NRAS, HSPA4, DNAJB6, PDCD11, PIP5K1A, DNAJC15, VANGL1, DNAJC11, FKBP5, HSPA4L, HSP90B1, GNAI2, DNAJC13, GNAS, PPP2CB, HSD11B2, DNAJB11, PLD2, RAP1B, WDR6, CPNE3, MYOF, COPA, UBLCP1, PPP1CA, RAD50, PIP4K2C, PHB, VIM, PGAM1, DNAJA1, MAP2K7, SPRY2, ALDOA, AP2B1, ATP5A1, SSB, IGF1R, JUP, PPP6C, PARP1, HSPB1, NME2, PRDX2, CCT7, RAB1A, FARSA, FASN, EPRS, TRAF2, REST, KIAA1429, NANOG, ITCH, SMURF2, WWP1, WWP2, PPP2CA, PPP2R2A, AURKA, LATS2, MAP2K3, MAP2K6, RASSF1, STK11, TERT, PEBP1, CRBN, FAR1, PSMC4, UBA52, UBB, UBC, RPS27A, HSPA6, HSP90AB3P, DSP, ATAD3A, ATAD3B, P4HB, SDF2L1, SLC25A22, SPTBN4, TMEM33, CTSB, NCL, HPX, TXNDC12, SLC25A11, NDUFA4, CTSV, FBP1, HSD17B3, ZNF189, ZNF510, KIF14, SRC, TRAP1, JTB, S100P, USP28,
TMPRSS2CLK1, HNRNPL, DCAF4, S, ACE2, STX7, SCD, PLP2, PLLP, MOSPD3, UPK2, SELK, C3orf52, IGFBP5, SEC22A, PLP1, CLN6, TMEM128, C14orf1, CFHR5, TMEM243, TMEM60, CXCL9, BNIP2, CNIH3, PGAP2, TMEM218, TMEM86A, CMTM7, ZFPL1, BMP10, TMEM79, SLC35A1, SFTPC, VAMP5, FAXDC2, STX8, NINJ2, CLEC7A, C2CD2L, CNIH2, BNIP3, DEFB103A, DEFB103B, TMEM11, C17orf62, TMEM86B, ADIPOQ, EDDM3B, BRICD5, PTTG1IP, PTCH1, ANKRD46, TMEM222, C1QL4, TMEM120B, FAM3C, TMEM229B, PLN, CTXN3, TNF, SMIM1, AQP1, TMPRSS2, DNASE2, MYO1C, PGRMC1, NDUFA4, ADAM10, CLGN, SEC16A, SPINT2, COCH, B4GAT1, XPOT, MYO1B, LANCL1, CALU, PLXNA2, GPC4, BANF1, CPD, CLPX, STC2, SLIT2, MYO1D, ERLIN2, BAG2, TFRC, HLA-A, TP53, RPN1, RPN2, GNAI2, APP, ITGB1, INSR, GLA, GPI, ITGAV, CTSD, APRT, IGF1R, MET, GNAI3, CLTA, CALM2, HLA-C, DLAT, HSPA5, LAMC1, LAMP1, IGF2R, PDIA4, P4HA1, HSP90B1, PVR, RPA2, ATP2A2, PFKL, CDH2, MSH3, RPA1, CALR, RPA3, LONP1, TGFBR1, DDOST, HADHA, ECE1, DNM2, FXR2, PLXNA3, ATP1B3, HADHB, SEC61A1, GNB1, NOMO3, PRKDC, TFAM, SLC7A5, PFKP, KIF23, FMR1, PTK7, ADAM15, CUL2, SCARB2, WRN, DSC3, ITIH4, GANAB, KARS, RCN1, SAFB, IMMT, HSD17B12, UBR4, QSOX2, RRM2B, MON2, YTHDF3, PABPN1, PLD3, PELP1, TTC13, CNNM3, IPO4, FAR1, GGH, ERLEC1, RBM33, DNAJA3, RBM14, PPP1R9B, SDF2, NEU1, GRWD1, AIF1L, NTPCR, FUCA2, EDEM3, RACGAP1, RAB18, TMEM106B, CHPF2, GNG12, DNAJB11, EGFL7, DDX20, ADAMTS1, LNPEP, ITM2B, MRPL11, HYOU1, AFG3L2, YTHDF2, SUPT16H, PDHX, IPO5, SAP18, HGS, SPTBN2, PLXNB2, ARPC3, ACTN4, TRIM13, PDCD6, MPDU1, SEC22B, ATP6AP2, STAM2, ARL6IP5, UFL1, SEC31A, STBD1, SMC2, SEC24A, SEC24B, ACSL3, CDK1, SRPR, SPTB, MTHFD1, ACTN1, ETFA, RAB6A, VDAC1, HMOX2, MYH10, DEK, ATP5C1, NAMPT, VDAC2, QARS, TUFM, SERPINH1, BCAP31, PSMD7, CLCN7, SLC25A1, YARS, EPPK1, RAB10, ABCE1, RHOA, CNBP, TPM4, SLC25A11, LMNB2, CKAP4, GOLGA3, TWF1, TRAP1, STX5, DDX39B, RAB3GAP1, PON2, PPA1, SEC23A, SEC23B, NDUFA9, ATP6V1F, INF2, ANO6, ACTBL2, MIA3, CDKAL1, KIAA0368, C19orf70, SLC25A24, HUWE1, MEGF8, KTN1, COMTD1, ANKLE2, VRK2, ZDHHC17, DNAH10, NUP93, MMGT1, TMEM199, ATPAF2, EMC1, PDZD8, NBEA, MOSPD2, PDCD6IP, SYNE2, UBXN4, CCDC47, LRRC59, C7orf55, DDRGK1, NGLY1, CDK5RAP3, CCDC115, CLCC1, OSBPL9, RBM15, CGRRF1, ESYT1, NDC1, EFHD1, OSBPL8, KIAA1715, LSG1, RAB1B, TMX1, GORASP2, SFXN1, XPO5, VEZT, JPH1, BIRC6, AAAS, TOMM22, DDX19A, SMPD4, TMOD3, EMC3, VAPA, CEP72, LARS, DPM3, DHCR7, UBA2, AASS, ATP6V1H, SLC25A13, STOML2, RAB21, MYO6, VDAC3, AUP1, SEC23IP,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TMPRSS2all structure
BRAFall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TMPRSS2-BRAF


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TMPRSS2-BRAF


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMPRSS2C0033578Prostatic Neoplasms4CTD_human
HgeneTMPRSS2C0376358Malignant neoplasm of prostate4CTD_human
TgeneBRAFC0025202melanoma24CGI;CTD_human;UNIPROT
TgeneBRAFC1275081Cardio-facio-cutaneous syndrome14CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneBRAFC0009402Colorectal Carcinoma8CTD_human;UNIPROT
TgeneBRAFC0028326Noonan Syndrome8CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneBRAFC0238463Papillary thyroid carcinoma8CTD_human;ORPHANET
TgeneBRAFC0040136Thyroid Neoplasm6CGI;CTD_human
TgeneBRAFC0151468Thyroid Gland Follicular Adenoma6CTD_human
TgeneBRAFC0175704LEOPARD Syndrome6CLINGEN;GENOMICS_ENGLAND
TgeneBRAFC0549473Thyroid carcinoma6CGI;CTD_human
TgeneBRAFC3150970NOONAN SYNDROME 75CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneBRAFC0009404Colorectal Neoplasms4CTD_human
TgeneBRAFC3150971LEOPARD SYNDROME 34CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneBRAFC1519086Pilomyxoid astrocytoma3ORPHANET
TgeneBRAFC0004565Melanoma, B162CTD_human
TgeneBRAFC0009075Melanoma, Cloudman S912CTD_human
TgeneBRAFC0018598Melanoma, Harding-Passey2CTD_human
TgeneBRAFC0023443Hairy Cell Leukemia2CGI;ORPHANET
TgeneBRAFC0025205Melanoma, Experimental2CTD_human
TgeneBRAFC0033578Prostatic Neoplasms2CTD_human
TgeneBRAFC0152013Adenocarcinoma of lung (disorder)2CGI;CTD_human
TgeneBRAFC0376358Malignant neoplasm of prostate2CTD_human
TgeneBRAFC0587248Costello syndrome (disorder)2CLINGEN;CTD_human
TgeneBRAFC3501843Nonmedullary Thyroid Carcinoma2CTD_human
TgeneBRAFC3501844Familial Nonmedullary Thyroid Cancer2CTD_human
TgeneBRAFC0002448Ameloblastoma1CTD_human
TgeneBRAFC0004114Astrocytoma1CTD_human
TgeneBRAFC0010276Craniopharyngioma1CTD_human;ORPHANET
TgeneBRAFC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneBRAFC0017638Glioma1CGI;CTD_human
TgeneBRAFC0019621Histiocytosis, Langerhans-Cell1CGI;ORPHANET
TgeneBRAFC0022665Kidney Neoplasm1CTD_human
TgeneBRAFC0023903Liver neoplasms1CTD_human
TgeneBRAFC0024232Lymphatic Metastasis1CTD_human
TgeneBRAFC0024694Mandibular Neoplasms1CTD_human
TgeneBRAFC0027659Neoplasms, Experimental1CTD_human
TgeneBRAFC0027962Melanocytic nevus1GENOMICS_ENGLAND
TgeneBRAFC0036920Sezary Syndrome1CTD_human
TgeneBRAFC0041409Turner Syndrome, Male1CTD_human
TgeneBRAFC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
TgeneBRAFC0205768Subependymal Giant Cell Astrocytoma1CTD_human
TgeneBRAFC0206686Adrenocortical carcinoma1CTD_human
TgeneBRAFC0206754Neuroendocrine Tumors1CTD_human
TgeneBRAFC0259783mixed gliomas1CTD_human
TgeneBRAFC0278875Adult Craniopharyngioma1CTD_human
TgeneBRAFC0280783Juvenile Pilocytic Astrocytoma1CTD_human
TgeneBRAFC0280785Diffuse Astrocytoma1CTD_human
TgeneBRAFC0334579Anaplastic astrocytoma1CGI;CTD_human
TgeneBRAFC0334580Protoplasmic astrocytoma1CTD_human
TgeneBRAFC0334581Gemistocytic astrocytoma1CTD_human
TgeneBRAFC0334582Fibrillary Astrocytoma1CTD_human
TgeneBRAFC0334583Pilocytic Astrocytoma1CGI;CTD_human
TgeneBRAFC0338070Childhood Cerebral Astrocytoma1CTD_human
TgeneBRAFC0345904Malignant neoplasm of liver1CTD_human
TgeneBRAFC0376407Granulomatous Slack Skin1CTD_human
TgeneBRAFC0406803Syringocystadenoma Papilliferum1GENOMICS_ENGLAND
TgeneBRAFC0431128Papillary craniopharyngioma1CTD_human
TgeneBRAFC0431129Adamantinous Craniopharyngioma1CTD_human
TgeneBRAFC0547065Mixed oligoastrocytoma1CTD_human
TgeneBRAFC0555198Malignant Glioma1CTD_human
TgeneBRAFC0596263Carcinogenesis1CTD_human
TgeneBRAFC0684249Carcinoma of lung1CGI;UNIPROT
TgeneBRAFC0740457Malignant neoplasm of kidney1CTD_human
TgeneBRAFC0750935Cerebral Astrocytoma1CTD_human
TgeneBRAFC0750936Intracranial Astrocytoma1CTD_human
TgeneBRAFC0751061Craniopharyngioma, Child1CTD_human
TgeneBRAFC0920269Microsatellite Instability1CTD_human
TgeneBRAFC1527404Female Pseudo-Turner Syndrome1CTD_human
TgeneBRAFC1704230Grade I Astrocytoma1CTD_human
TgeneBRAFC1721098Replication Error Phenotype1CTD_human
TgeneBRAFC2239176Liver carcinoma1CTD_human
TgeneBRAFC4551484Leopard Syndrome 11GENOMICS_ENGLAND
TgeneBRAFC4551602Noonan Syndrome 11CTD_human
TgeneBRAFC4721532Lymphoma, Non-Hodgkin, Familial1UNIPROT
TgeneBRAFC4733333familial non-medullary thyroid cancer1GENOMICS_ENGLAND