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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TMPRSS2-ETV1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TMPRSS2-ETV1
FusionPDB ID: 92378
FusionGDB2.0 ID: 92378
HgeneTgene
Gene symbol

TMPRSS2

ETV1

Gene ID

7113

2115

Gene nametransmembrane serine protease 2ETS variant transcription factor 1
SynonymsPP9284|PRSS10ER81
Cytomap

21q22.3

7p21.2

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2ETS translocation variant 1ETS variant 1ets variant gene 1ets-related protein 81
Modification date2020031320200313
UniProtAcc

O15393

P50549

Ensembl transtripts involved in fusion geneENST idsENST00000332149, ENST00000398585, 
ENST00000458356, ENST00000497881, 
ENST00000476720, ENST00000242066, 
ENST00000343495, ENST00000403527, 
ENST00000403685, ENST00000405192, 
ENST00000405218, ENST00000405358, 
ENST00000420159, ENST00000399357, 
ENST00000430479, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score40 X 73 X 10=2920013 X 27 X 6=2106
# samples 13030
** MAII scorelog2(130/29200*10)=-4.48938484073892
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(30/2106*10)=-2.81147103052984
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TMPRSS2 [Title/Abstract] AND ETV1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TMPRSS2(42880007)-ETV1(13978871), # samples:6
Anticipated loss of major functional domain due to fusion event.TMPRSS2-ETV1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ETV1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ETV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ETV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ETV1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TMPRSS2-ETV1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TMPRSS2-ETV1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TMPRSS2-ETV1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

HgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843

TgeneETV1

GO:0045944

positive regulation of transcription by RNA polymerase II

12750007


check buttonFusion gene breakpoints across TMPRSS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ETV1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-5501-01ATMPRSS2chr21

42879877

-ETV1chr7

13978871

-
ChimerDB4PRADTCGA-EJ-5501-01ATMPRSS2chr21

42880007

-ETV1chr7

13978870

-
ChimerDB4PRADTCGA-EJ-5501TMPRSS2chr21

42879876

-ETV1chr7

13978871

-
ChimerDB4PRADTCGA-EJ-5501TMPRSS2chr21

42879877

-ETV1chr7

13978871

-
ChimerDB4PRADTCGA-EJ-5501TMPRSS2chr21

42880007

-ETV1chr7

13978871

-
ChimerDB4PRADTCGA-EJ-5501TMPRSS2chr21

42880008

-ETV1chr7

13978871

-
ChimerDB4PRADTCGA-EJ-7788-01ATMPRSS2chr21

42870045

-ETV1chr7

13978870

-
ChimerDB4PRADTCGA-EJ-7788-01ATMPRSS2chr21

42870046

-ETV1chr7

13978871

-
ChimerDB4PRADTCGA-EJ-7788-01ATMPRSS2chr21

42880007

-ETV1chr7

13978870

-
ChimerDB4PRADTCGA-EJ-7788TMPRSS2chr21

42870045

-ETV1chr7

13978871

-
ChimerDB4PRADTCGA-EJ-7788TMPRSS2chr21

42870046

-ETV1chr7

13978871

-
ChimerDB4PRADTCGA-EJ-7788TMPRSS2chr21

42880007

-ETV1chr7

13978871

-
ChimerDB4PRADTCGA-EJ-7788TMPRSS2chr21

42880008

-ETV1chr7

13978871

-
ChimerDB4PRADTCGA-HC-7818-01ATMPRSS2chr21

42866282

-ETV1chr7

13950931

-
ChimerDB4PRADTCGA-HC-7818-01ATMPRSS2chr21

42866282

-ETV1chr7

13971373

-
ChimerDB4PRADTCGA-HC-7818-01ATMPRSS2chr21

42866283

-ETV1chr7

13971374

-
ChimerDB4PRADTCGA-HC-7818-01ATMPRSS2chr21

42870045

-ETV1chr7

13971373

-
ChimerDB4PRADTCGA-HC-7818-01ATMPRSS2chr21

42880007

-ETV1chr7

13971373

-
ChimerDB4PRADTCGA-HC-7818TMPRSS2chr21

42866282

-ETV1chr7

13971374

-
ChimerDB4PRADTCGA-HC-7818TMPRSS2chr21

42866283

-ETV1chr7

13950932

-
ChimerDB4PRADTCGA-HC-7818TMPRSS2chr21

42866283

-ETV1chr7

13971374

-
ChimerDB4PRADTCGA-HC-7818TMPRSS2chr21

42866407

-ETV1chr7

13971374

-
ChimerDB4PRADTCGA-HC-7818TMPRSS2chr21

42870045

-ETV1chr7

13971374

-
ChimerDB4PRADTCGA-HC-7818TMPRSS2chr21

42870046

-ETV1chr7

13971374

-
ChimerDB4PRADTCGA-HC-7818TMPRSS2chr21

42880007

-ETV1chr7

13971374

-
ChimerDB4PRADTCGA-HC-7818TMPRSS2chr21

42880008

-ETV1chr7

13971374

-
ChimerDB4PRADTCGA-YL-A8SC-01ATMPRSS2chr21

42879876

-ETV1chr7

13978870

-
ChimerDB4PRADTCGA-YL-A8SC-01ATMPRSS2chr21

42879877

-ETV1chr7

13978871

-
ChimerDB4PRADTCGA-YL-A8SC-01ATMPRSS2chr21

42880007

-ETV1chr7

13978870

-
ChimerDB4PRADTCGA-YL-A8SCTMPRSS2chr21

42879876

-ETV1chr7

13978871

-
ChimerDB4PRADTCGA-YL-A8SCTMPRSS2chr21

42880007

-ETV1chr7

13971374

-
ChimerDB4PRADTCGA-YL-A8SCTMPRSS2chr21

42880007

-ETV1chr7

13978871

-
ChimerDB4PRADTCGA-YL-A8SCTMPRSS2chr21

42880008

-ETV1chr7

13978871

-
ChimerDB4prostate cancerDQ204770TMPRSS2chr21

42880082

ETV1chr7

14017052
ChimerKB3..TMPRSS2chr21

42879876

-ETV1chr7

13978871

-
ChimerKB3..TMPRSS2chr21

42879876

-ETV1chr7

14026310

-
ChimerKB3..TMPRSS2chr21

42880007

-ETV1chr7

13975521

-
ChiTaRS5.0N/ADQ204770TMPRSS2chr21

42880008

-ETV1chr7

14017108

-
ChiTaRS5.0N/ADQ204771TMPRSS2chr21

42870046

-ETV1chr7

14017105

-
ChiTaRS5.0N/AEU090249TMPRSS2chr21

42866302

-ETV1chr7

13975469

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000458356TMPRSS2chr2142870045-ENST00000430479ETV1chr713971374-5622104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000399357ETV1chr713971374-5617104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000420159ETV1chr713971374-5617104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000343495ETV1chr713971374-5617104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000242066ETV1chr713971374-5617104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000405192ETV1chr713971374-3751104147914255
ENST00000458356TMPRSS2chr2142870045-ENST00000405358ETV1chr713971374-3582104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000403527ETV1chr713971374-2695104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000405218ETV1chr713971374-2469104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000403685ETV1chr713971374-992104147983278
ENST00000458356TMPRSS2chr2142870046-ENST00000430479ETV1chr713971374-5622104147983278
ENST00000458356TMPRSS2chr2142870046-ENST00000399357ETV1chr713971374-5617104147983278
ENST00000458356TMPRSS2chr2142870046-ENST00000420159ETV1chr713971374-5617104147983278
ENST00000458356TMPRSS2chr2142870046-ENST00000343495ETV1chr713971374-5617104147983278
ENST00000458356TMPRSS2chr2142870046-ENST00000242066ETV1chr713971374-5617104147983278
ENST00000458356TMPRSS2chr2142870046-ENST00000405192ETV1chr713971374-3751104147914255
ENST00000458356TMPRSS2chr2142870046-ENST00000405358ETV1chr713971374-3582104147983278
ENST00000458356TMPRSS2chr2142870046-ENST00000403527ETV1chr713971374-2695104147983278
ENST00000458356TMPRSS2chr2142870046-ENST00000405218ETV1chr713971374-2469104147983278
ENST00000458356TMPRSS2chr2142870046-ENST00000403685ETV1chr713971374-992104147983278
ENST00000332149TMPRSS2chr2142866283-ENST00000430479ETV1chr713950932-56433731351004289
ENST00000332149TMPRSS2chr2142866283-ENST00000399357ETV1chr713950932-56383731351004289
ENST00000332149TMPRSS2chr2142866283-ENST00000420159ETV1chr713950932-56383731351004289
ENST00000332149TMPRSS2chr2142866283-ENST00000343495ETV1chr713950932-56383731351004289
ENST00000332149TMPRSS2chr2142866283-ENST00000242066ETV1chr713950932-56383731351004289
ENST00000398585TMPRSS2chr2142866283-ENST00000430479ETV1chr713950932-5680410401041333
ENST00000398585TMPRSS2chr2142866283-ENST00000399357ETV1chr713950932-5675410401041333
ENST00000398585TMPRSS2chr2142866283-ENST00000420159ETV1chr713950932-5675410401041333
ENST00000398585TMPRSS2chr2142866283-ENST00000343495ETV1chr713950932-5675410401041333
ENST00000398585TMPRSS2chr2142866283-ENST00000242066ETV1chr713950932-5675410401041333
ENST00000458356TMPRSS2chr2142870045-ENST00000430479ETV1chr713971373-5622104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000399357ETV1chr713971373-5617104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000420159ETV1chr713971373-5617104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000343495ETV1chr713971373-5617104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000242066ETV1chr713971373-5617104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000405192ETV1chr713971373-3751104147914255
ENST00000458356TMPRSS2chr2142870045-ENST00000405358ETV1chr713971373-3582104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000403527ETV1chr713971373-2695104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000405218ETV1chr713971373-2469104147983278
ENST00000458356TMPRSS2chr2142870045-ENST00000403685ETV1chr713971373-992104147983278
ENST00000332149TMPRSS2chr2142866282-ENST00000430479ETV1chr713950931-56433731351004289
ENST00000332149TMPRSS2chr2142866282-ENST00000399357ETV1chr713950931-56383731351004289
ENST00000332149TMPRSS2chr2142866282-ENST00000420159ETV1chr713950931-56383731351004289
ENST00000332149TMPRSS2chr2142866282-ENST00000343495ETV1chr713950931-56383731351004289
ENST00000332149TMPRSS2chr2142866282-ENST00000242066ETV1chr713950931-56383731351004289
ENST00000398585TMPRSS2chr2142866282-ENST00000430479ETV1chr713950931-5680410401041333
ENST00000398585TMPRSS2chr2142866282-ENST00000399357ETV1chr713950931-5675410401041333
ENST00000398585TMPRSS2chr2142866282-ENST00000420159ETV1chr713950931-5675410401041333
ENST00000398585TMPRSS2chr2142866282-ENST00000343495ETV1chr713950931-5675410401041333
ENST00000398585TMPRSS2chr2142866282-ENST00000242066ETV1chr713950931-5675410401041333

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000458356ENST00000430479TMPRSS2chr2142870045-ETV1chr713971374-0.0001846660.9998154
ENST00000458356ENST00000399357TMPRSS2chr2142870045-ETV1chr713971374-0.0001859540.9998141
ENST00000458356ENST00000420159TMPRSS2chr2142870045-ETV1chr713971374-0.0001859540.9998141
ENST00000458356ENST00000343495TMPRSS2chr2142870045-ETV1chr713971374-0.0001859540.9998141
ENST00000458356ENST00000242066TMPRSS2chr2142870045-ETV1chr713971374-0.0001859540.9998141
ENST00000458356ENST00000405192TMPRSS2chr2142870045-ETV1chr713971374-0.0005252120.9994748
ENST00000458356ENST00000405358TMPRSS2chr2142870045-ETV1chr713971374-0.000165090.9998349
ENST00000458356ENST00000403527TMPRSS2chr2142870045-ETV1chr713971374-0.000230480.9997695
ENST00000458356ENST00000405218TMPRSS2chr2142870045-ETV1chr713971374-0.0002359360.999764
ENST00000458356ENST00000403685TMPRSS2chr2142870045-ETV1chr713971374-0.0004075490.9995925
ENST00000458356ENST00000430479TMPRSS2chr2142870046-ETV1chr713971374-0.0001846660.9998154
ENST00000458356ENST00000399357TMPRSS2chr2142870046-ETV1chr713971374-0.0001859540.9998141
ENST00000458356ENST00000420159TMPRSS2chr2142870046-ETV1chr713971374-0.0001859540.9998141
ENST00000458356ENST00000343495TMPRSS2chr2142870046-ETV1chr713971374-0.0001859540.9998141
ENST00000458356ENST00000242066TMPRSS2chr2142870046-ETV1chr713971374-0.0001859540.9998141
ENST00000458356ENST00000405192TMPRSS2chr2142870046-ETV1chr713971374-0.0005252120.9994748
ENST00000458356ENST00000405358TMPRSS2chr2142870046-ETV1chr713971374-0.000165090.9998349
ENST00000458356ENST00000403527TMPRSS2chr2142870046-ETV1chr713971374-0.000230480.9997695
ENST00000458356ENST00000405218TMPRSS2chr2142870046-ETV1chr713971374-0.0002359360.999764
ENST00000458356ENST00000403685TMPRSS2chr2142870046-ETV1chr713971374-0.0004075490.9995925
ENST00000332149ENST00000430479TMPRSS2chr2142866283-ETV1chr713950932-0.0001762110.99982387
ENST00000332149ENST00000399357TMPRSS2chr2142866283-ETV1chr713950932-0.0001769950.99982303
ENST00000332149ENST00000420159TMPRSS2chr2142866283-ETV1chr713950932-0.0001769950.99982303
ENST00000332149ENST00000343495TMPRSS2chr2142866283-ETV1chr713950932-0.0001769950.99982303
ENST00000332149ENST00000242066TMPRSS2chr2142866283-ETV1chr713950932-0.0001769950.99982303
ENST00000398585ENST00000430479TMPRSS2chr2142866283-ETV1chr713950932-0.0001126230.99988735
ENST00000398585ENST00000399357TMPRSS2chr2142866283-ETV1chr713950932-0.0001125550.99988747
ENST00000398585ENST00000420159TMPRSS2chr2142866283-ETV1chr713950932-0.0001125550.99988747
ENST00000398585ENST00000343495TMPRSS2chr2142866283-ETV1chr713950932-0.0001125550.99988747
ENST00000398585ENST00000242066TMPRSS2chr2142866283-ETV1chr713950932-0.0001125550.99988747
ENST00000458356ENST00000430479TMPRSS2chr2142870045-ETV1chr713971373-0.0001846660.9998154
ENST00000458356ENST00000399357TMPRSS2chr2142870045-ETV1chr713971373-0.0001859540.9998141
ENST00000458356ENST00000420159TMPRSS2chr2142870045-ETV1chr713971373-0.0001859540.9998141
ENST00000458356ENST00000343495TMPRSS2chr2142870045-ETV1chr713971373-0.0001859540.9998141
ENST00000458356ENST00000242066TMPRSS2chr2142870045-ETV1chr713971373-0.0001859540.9998141
ENST00000458356ENST00000405192TMPRSS2chr2142870045-ETV1chr713971373-0.0005252120.9994748
ENST00000458356ENST00000405358TMPRSS2chr2142870045-ETV1chr713971373-0.000165090.9998349
ENST00000458356ENST00000403527TMPRSS2chr2142870045-ETV1chr713971373-0.000230480.9997695
ENST00000458356ENST00000405218TMPRSS2chr2142870045-ETV1chr713971373-0.0002359360.999764
ENST00000458356ENST00000403685TMPRSS2chr2142870045-ETV1chr713971373-0.0004075490.9995925
ENST00000332149ENST00000430479TMPRSS2chr2142866282-ETV1chr713950931-0.0001762110.99982387
ENST00000332149ENST00000399357TMPRSS2chr2142866282-ETV1chr713950931-0.0001769950.99982303
ENST00000332149ENST00000420159TMPRSS2chr2142866282-ETV1chr713950931-0.0001769950.99982303
ENST00000332149ENST00000343495TMPRSS2chr2142866282-ETV1chr713950931-0.0001769950.99982303
ENST00000332149ENST00000242066TMPRSS2chr2142866282-ETV1chr713950931-0.0001769950.99982303
ENST00000398585ENST00000430479TMPRSS2chr2142866282-ETV1chr713950931-0.0001126230.99988735
ENST00000398585ENST00000399357TMPRSS2chr2142866282-ETV1chr713950931-0.0001125550.99988747
ENST00000398585ENST00000420159TMPRSS2chr2142866282-ETV1chr713950931-0.0001125550.99988747
ENST00000398585ENST00000343495TMPRSS2chr2142866282-ETV1chr713950931-0.0001125550.99988747
ENST00000398585ENST00000242066TMPRSS2chr2142866282-ETV1chr713950931-0.0001125550.99988747

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>92378_92378_1_TMPRSS2-ETV1_TMPRSS2_chr21_42866282_ENST00000332149_ETV1_chr7_13950931_ENST00000242066_length(amino acids)=289AA_BP=78
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMR
QEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEP
EEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMA

--------------------------------------------------------------

>92378_92378_2_TMPRSS2-ETV1_TMPRSS2_chr21_42866282_ENST00000332149_ETV1_chr7_13950931_ENST00000343495_length(amino acids)=289AA_BP=78
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMR
QEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEP
EEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMA

--------------------------------------------------------------

>92378_92378_3_TMPRSS2-ETV1_TMPRSS2_chr21_42866282_ENST00000332149_ETV1_chr7_13950931_ENST00000399357_length(amino acids)=289AA_BP=78
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMR
QEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEP
EEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMA

--------------------------------------------------------------

>92378_92378_4_TMPRSS2-ETV1_TMPRSS2_chr21_42866282_ENST00000332149_ETV1_chr7_13950931_ENST00000420159_length(amino acids)=289AA_BP=78
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMR
QEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEP
EEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMA

--------------------------------------------------------------

>92378_92378_5_TMPRSS2-ETV1_TMPRSS2_chr21_42866282_ENST00000332149_ETV1_chr7_13950931_ENST00000430479_length(amino acids)=289AA_BP=78
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMR
QEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEP
EEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMA

--------------------------------------------------------------

>92378_92378_6_TMPRSS2-ETV1_TMPRSS2_chr21_42866282_ENST00000398585_ETV1_chr7_13950931_ENST00000242066_length(amino acids)=333AA_BP=122
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYR
EGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKF

--------------------------------------------------------------

>92378_92378_7_TMPRSS2-ETV1_TMPRSS2_chr21_42866282_ENST00000398585_ETV1_chr7_13950931_ENST00000343495_length(amino acids)=333AA_BP=122
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYR
EGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKF

--------------------------------------------------------------

>92378_92378_8_TMPRSS2-ETV1_TMPRSS2_chr21_42866282_ENST00000398585_ETV1_chr7_13950931_ENST00000399357_length(amino acids)=333AA_BP=122
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYR
EGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKF

--------------------------------------------------------------

>92378_92378_9_TMPRSS2-ETV1_TMPRSS2_chr21_42866282_ENST00000398585_ETV1_chr7_13950931_ENST00000420159_length(amino acids)=333AA_BP=122
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYR
EGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKF

--------------------------------------------------------------

>92378_92378_10_TMPRSS2-ETV1_TMPRSS2_chr21_42866282_ENST00000398585_ETV1_chr7_13950931_ENST00000430479_length(amino acids)=333AA_BP=122
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYR
EGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKF

--------------------------------------------------------------

>92378_92378_11_TMPRSS2-ETV1_TMPRSS2_chr21_42866283_ENST00000332149_ETV1_chr7_13950932_ENST00000242066_length(amino acids)=289AA_BP=78
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMR
QEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEP
EEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMA

--------------------------------------------------------------

>92378_92378_12_TMPRSS2-ETV1_TMPRSS2_chr21_42866283_ENST00000332149_ETV1_chr7_13950932_ENST00000343495_length(amino acids)=289AA_BP=78
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMR
QEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEP
EEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMA

--------------------------------------------------------------

>92378_92378_13_TMPRSS2-ETV1_TMPRSS2_chr21_42866283_ENST00000332149_ETV1_chr7_13950932_ENST00000399357_length(amino acids)=289AA_BP=78
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMR
QEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEP
EEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMA

--------------------------------------------------------------

>92378_92378_14_TMPRSS2-ETV1_TMPRSS2_chr21_42866283_ENST00000332149_ETV1_chr7_13950932_ENST00000420159_length(amino acids)=289AA_BP=78
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMR
QEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEP
EEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMA

--------------------------------------------------------------

>92378_92378_15_TMPRSS2-ETV1_TMPRSS2_chr21_42866283_ENST00000332149_ETV1_chr7_13950932_ENST00000430479_length(amino acids)=289AA_BP=78
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMR
QEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEP
EEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMA

--------------------------------------------------------------

>92378_92378_16_TMPRSS2-ETV1_TMPRSS2_chr21_42866283_ENST00000398585_ETV1_chr7_13950932_ENST00000242066_length(amino acids)=333AA_BP=122
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYR
EGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKF

--------------------------------------------------------------

>92378_92378_17_TMPRSS2-ETV1_TMPRSS2_chr21_42866283_ENST00000398585_ETV1_chr7_13950932_ENST00000343495_length(amino acids)=333AA_BP=122
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYR
EGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKF

--------------------------------------------------------------

>92378_92378_18_TMPRSS2-ETV1_TMPRSS2_chr21_42866283_ENST00000398585_ETV1_chr7_13950932_ENST00000399357_length(amino acids)=333AA_BP=122
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYR
EGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKF

--------------------------------------------------------------

>92378_92378_19_TMPRSS2-ETV1_TMPRSS2_chr21_42866283_ENST00000398585_ETV1_chr7_13950932_ENST00000420159_length(amino acids)=333AA_BP=122
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYR
EGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKF

--------------------------------------------------------------

>92378_92378_20_TMPRSS2-ETV1_TMPRSS2_chr21_42866283_ENST00000398585_ETV1_chr7_13950932_ENST00000430479_length(amino acids)=333AA_BP=122
MGAWDPPMPPAPPGGESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYP
SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYR
EGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKF

--------------------------------------------------------------

>92378_92378_21_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971373_ENST00000242066_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_22_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971373_ENST00000343495_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_23_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971373_ENST00000399357_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_24_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971373_ENST00000403527_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_25_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971373_ENST00000403685_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_26_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971373_ENST00000405192_length(amino acids)=255AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSGCMFEKGPRQFYDDTCVVPEKF
DGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIM

--------------------------------------------------------------

>92378_92378_27_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971373_ENST00000405218_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_28_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971373_ENST00000405358_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_29_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971373_ENST00000420159_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_30_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971373_ENST00000430479_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_31_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971374_ENST00000242066_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_32_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971374_ENST00000343495_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_33_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971374_ENST00000399357_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_34_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971374_ENST00000403527_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_35_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971374_ENST00000403685_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_36_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971374_ENST00000405192_length(amino acids)=255AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSGCMFEKGPRQFYDDTCVVPEKF
DGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIM

--------------------------------------------------------------

>92378_92378_37_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971374_ENST00000405218_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_38_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971374_ENST00000405358_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_39_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971374_ENST00000420159_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_40_TMPRSS2-ETV1_TMPRSS2_chr21_42870045_ENST00000458356_ETV1_chr7_13971374_ENST00000430479_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_41_TMPRSS2-ETV1_TMPRSS2_chr21_42870046_ENST00000458356_ETV1_chr7_13971374_ENST00000242066_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_42_TMPRSS2-ETV1_TMPRSS2_chr21_42870046_ENST00000458356_ETV1_chr7_13971374_ENST00000343495_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_43_TMPRSS2-ETV1_TMPRSS2_chr21_42870046_ENST00000458356_ETV1_chr7_13971374_ENST00000399357_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_44_TMPRSS2-ETV1_TMPRSS2_chr21_42870046_ENST00000458356_ETV1_chr7_13971374_ENST00000403527_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_45_TMPRSS2-ETV1_TMPRSS2_chr21_42870046_ENST00000458356_ETV1_chr7_13971374_ENST00000403685_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_46_TMPRSS2-ETV1_TMPRSS2_chr21_42870046_ENST00000458356_ETV1_chr7_13971374_ENST00000405192_length(amino acids)=255AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSGCMFEKGPRQFYDDTCVVPEKF
DGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIM

--------------------------------------------------------------

>92378_92378_47_TMPRSS2-ETV1_TMPRSS2_chr21_42870046_ENST00000458356_ETV1_chr7_13971374_ENST00000405218_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_48_TMPRSS2-ETV1_TMPRSS2_chr21_42870046_ENST00000458356_ETV1_chr7_13971374_ENST00000405358_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_49_TMPRSS2-ETV1_TMPRSS2_chr21_42870046_ENST00000458356_ETV1_chr7_13971374_ENST00000420159_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

>92378_92378_50_TMPRSS2-ETV1_TMPRSS2_chr21_42870046_ENST00000458356_ETV1_chr7_13971374_ENST00000430479_length(amino acids)=278AA_BP=
MPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRT
EGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQK
NRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPH

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:42880007/chr7:13978871)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TMPRSS2

O15393

ETV1

P50549

FUNCTION: Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity). {ECO:0000250|UniProtKB:Q9JIQ8, ECO:0000269|PubMed:15537383, ECO:0000269|PubMed:25122198, ECO:0000269|PubMed:26018085}.; FUNCTION: (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436, PubMed:34159616, PubMed:33051876). Upon SARS-CoV-2 infection, increases syncytia formation by accelerating the fusion process (PubMed:34159616, PubMed:33051876). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. {ECO:0000269|PubMed:21068237, ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651, ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32404436, ECO:0000269|PubMed:33051876, ECO:0000269|PubMed:34159616}.FUNCTION: Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:7651741). Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (By similarity). {ECO:0000250|UniProtKB:P41164, ECO:0000269|PubMed:7651741}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000398585-3141_84116.33333333333333530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000398585-3141_84116.33333333333333530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000398585-31485_105116.33333333333333530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000398585-31485_105116.33333333333333530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneETV1chr21:42866282chr7:13950931ENST00000242066713335_415249.33333333333334460.0DNA bindingETS
TgeneETV1chr21:42866282chr7:13950931ENST00000343495713335_415249.33333333333334460.0DNA bindingETS
TgeneETV1chr21:42866282chr7:13950931ENST0000039935739335_415164.33333333333334375.0DNA bindingETS
TgeneETV1chr21:42866282chr7:13950931ENST00000403527410335_415227.33333333333334438.0DNA bindingETS
TgeneETV1chr21:42866282chr7:13950931ENST00000403685612335_415249.33333333333334460.0DNA bindingETS
TgeneETV1chr21:42866282chr7:13950931ENST00000405192012335_4150455.0DNA bindingETS
TgeneETV1chr21:42866282chr7:13950931ENST00000405218713335_415267.3333333333333478.0DNA bindingETS
TgeneETV1chr21:42866282chr7:13950931ENST0000042015939335_415209.33333333333334420.0DNA bindingETS
TgeneETV1chr21:42866282chr7:13950931ENST00000430479814335_415267.3333333333333478.0DNA bindingETS
TgeneETV1chr21:42866283chr7:13950932ENST00000242066713335_415249.33333333333334460.0DNA bindingETS
TgeneETV1chr21:42866283chr7:13950932ENST00000343495713335_415249.33333333333334460.0DNA bindingETS
TgeneETV1chr21:42866283chr7:13950932ENST0000039935739335_415164.33333333333334375.0DNA bindingETS
TgeneETV1chr21:42866283chr7:13950932ENST00000403527410335_415227.33333333333334438.0DNA bindingETS
TgeneETV1chr21:42866283chr7:13950932ENST00000403685612335_415249.33333333333334460.0DNA bindingETS
TgeneETV1chr21:42866283chr7:13950932ENST00000405192012335_4150455.0DNA bindingETS
TgeneETV1chr21:42866283chr7:13950932ENST00000405218713335_415267.3333333333333478.0DNA bindingETS
TgeneETV1chr21:42866283chr7:13950932ENST0000042015939335_415209.33333333333334420.0DNA bindingETS
TgeneETV1chr21:42866283chr7:13950932ENST00000430479814335_415267.3333333333333478.0DNA bindingETS
TgeneETV1chr21:42870045chr7:13971373ENST00000242066613335_415166.66666666666666460.0DNA bindingETS
TgeneETV1chr21:42870045chr7:13971373ENST00000343495613335_415166.66666666666666460.0DNA bindingETS
TgeneETV1chr21:42870045chr7:13971373ENST0000039935729335_41581.66666666666667375.0DNA bindingETS
TgeneETV1chr21:42870045chr7:13971373ENST00000403527310335_415144.66666666666666438.0DNA bindingETS
TgeneETV1chr21:42870045chr7:13971373ENST00000403685512335_415166.66666666666666460.0DNA bindingETS
TgeneETV1chr21:42870045chr7:13971373ENST00000405192612335_415184.66666666666666455.0DNA bindingETS
TgeneETV1chr21:42870045chr7:13971373ENST00000405218613335_415184.66666666666666478.0DNA bindingETS
TgeneETV1chr21:42870045chr7:13971373ENST0000042015929335_415126.66666666666667420.0DNA bindingETS
TgeneETV1chr21:42870045chr7:13971373ENST00000430479714335_415184.66666666666666478.0DNA bindingETS
TgeneETV1chr21:42870045chr7:13971374ENST00000242066613335_415166.66666666666666460.0DNA bindingETS
TgeneETV1chr21:42870045chr7:13971374ENST00000343495613335_415166.66666666666666460.0DNA bindingETS
TgeneETV1chr21:42870045chr7:13971374ENST0000039935729335_41581.66666666666667375.0DNA bindingETS
TgeneETV1chr21:42870045chr7:13971374ENST00000403527310335_415144.66666666666666438.0DNA bindingETS
TgeneETV1chr21:42870045chr7:13971374ENST00000403685512335_415166.66666666666666460.0DNA bindingETS
TgeneETV1chr21:42870045chr7:13971374ENST00000405192612335_415184.66666666666666455.0DNA bindingETS
TgeneETV1chr21:42870045chr7:13971374ENST00000405218613335_415184.66666666666666478.0DNA bindingETS
TgeneETV1chr21:42870045chr7:13971374ENST0000042015929335_415126.66666666666667420.0DNA bindingETS
TgeneETV1chr21:42870045chr7:13971374ENST00000430479714335_415184.66666666666666478.0DNA bindingETS
TgeneETV1chr21:42870046chr7:13971374ENST00000242066613335_415166.66666666666666460.0DNA bindingETS
TgeneETV1chr21:42870046chr7:13971374ENST00000343495613335_415166.66666666666666460.0DNA bindingETS
TgeneETV1chr21:42870046chr7:13971374ENST0000039935729335_41581.66666666666667375.0DNA bindingETS
TgeneETV1chr21:42870046chr7:13971374ENST00000403527310335_415144.66666666666666438.0DNA bindingETS
TgeneETV1chr21:42870046chr7:13971374ENST00000403685512335_415166.66666666666666460.0DNA bindingETS
TgeneETV1chr21:42870046chr7:13971374ENST00000405192612335_415184.66666666666666455.0DNA bindingETS
TgeneETV1chr21:42870046chr7:13971374ENST00000405218613335_415184.66666666666666478.0DNA bindingETS
TgeneETV1chr21:42870046chr7:13971374ENST0000042015929335_415126.66666666666667420.0DNA bindingETS
TgeneETV1chr21:42870046chr7:13971374ENST00000430479714335_415184.66666666666666478.0DNA bindingETS

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000332149-314112_14979.33333333333333493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000332149-314150_24279.33333333333333493.0DomainSRCR
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000332149-314256_48979.33333333333333493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000398585-314112_149116.33333333333333530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000398585-314150_242116.33333333333333530.0DomainSRCR
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000398585-314256_489116.33333333333333530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000458356-314112_14979.33333333333333493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000458356-314150_24279.33333333333333493.0DomainSRCR
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000458356-314256_48979.33333333333333493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000332149-314112_14979.33333333333333493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000332149-314150_24279.33333333333333493.0DomainSRCR
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000332149-314256_48979.33333333333333493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000398585-314112_149116.33333333333333530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000398585-314150_242116.33333333333333530.0DomainSRCR
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000398585-314256_489116.33333333333333530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000458356-314112_14979.33333333333333493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000458356-314150_24279.33333333333333493.0DomainSRCR
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000458356-314256_48979.33333333333333493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870045chr7:13971373ENST00000332149-214112_1495.0493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870045chr7:13971373ENST00000332149-214150_2425.0493.0DomainSRCR
HgeneTMPRSS2chr21:42870045chr7:13971373ENST00000332149-214256_4895.0493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870045chr7:13971373ENST00000398585-214112_14942.0530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870045chr7:13971373ENST00000398585-214150_24242.0530.0DomainSRCR
HgeneTMPRSS2chr21:42870045chr7:13971373ENST00000398585-214256_48942.0530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870045chr7:13971373ENST00000458356-214112_1495.0493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870045chr7:13971373ENST00000458356-214150_2425.0493.0DomainSRCR
HgeneTMPRSS2chr21:42870045chr7:13971373ENST00000458356-214256_4895.0493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870045chr7:13971374ENST00000332149-214112_1495.0493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870045chr7:13971374ENST00000332149-214150_2425.0493.0DomainSRCR
HgeneTMPRSS2chr21:42870045chr7:13971374ENST00000332149-214256_4895.0493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870045chr7:13971374ENST00000398585-214112_14942.0530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870045chr7:13971374ENST00000398585-214150_24242.0530.0DomainSRCR
HgeneTMPRSS2chr21:42870045chr7:13971374ENST00000398585-214256_48942.0530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870045chr7:13971374ENST00000458356-214112_1495.0493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870045chr7:13971374ENST00000458356-214150_2425.0493.0DomainSRCR
HgeneTMPRSS2chr21:42870045chr7:13971374ENST00000458356-214256_4895.0493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870046chr7:13971374ENST00000332149-214112_1495.0493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870046chr7:13971374ENST00000332149-214150_2425.0493.0DomainSRCR
HgeneTMPRSS2chr21:42870046chr7:13971374ENST00000332149-214256_4895.0493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870046chr7:13971374ENST00000398585-214112_14942.0530.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870046chr7:13971374ENST00000398585-214150_24242.0530.0DomainSRCR
HgeneTMPRSS2chr21:42870046chr7:13971374ENST00000398585-214256_48942.0530.0DomainPeptidase S1
HgeneTMPRSS2chr21:42870046chr7:13971374ENST00000458356-214112_1495.0493.0DomainLDL-receptor class A
HgeneTMPRSS2chr21:42870046chr7:13971374ENST00000458356-214150_2425.0493.0DomainSRCR
HgeneTMPRSS2chr21:42870046chr7:13971374ENST00000458356-214256_4895.0493.0DomainPeptidase S1
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000332149-314106_49279.33333333333333493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000332149-3141_8479.33333333333333493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000398585-314106_492116.33333333333333530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000458356-314106_49279.33333333333333493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000458356-3141_8479.33333333333333493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000332149-314106_49279.33333333333333493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000332149-3141_8479.33333333333333493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000398585-314106_492116.33333333333333530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000458356-314106_49279.33333333333333493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000458356-3141_8479.33333333333333493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870045chr7:13971373ENST00000332149-214106_4925.0493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870045chr7:13971373ENST00000332149-2141_845.0493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870045chr7:13971373ENST00000398585-214106_49242.0530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870045chr7:13971373ENST00000398585-2141_8442.0530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870045chr7:13971373ENST00000458356-214106_4925.0493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870045chr7:13971373ENST00000458356-2141_845.0493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870045chr7:13971374ENST00000332149-214106_4925.0493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870045chr7:13971374ENST00000332149-2141_845.0493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870045chr7:13971374ENST00000398585-214106_49242.0530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870045chr7:13971374ENST00000398585-2141_8442.0530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870045chr7:13971374ENST00000458356-214106_4925.0493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870045chr7:13971374ENST00000458356-2141_845.0493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870046chr7:13971374ENST00000332149-214106_4925.0493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870046chr7:13971374ENST00000332149-2141_845.0493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870046chr7:13971374ENST00000398585-214106_49242.0530.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870046chr7:13971374ENST00000398585-2141_8442.0530.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42870046chr7:13971374ENST00000458356-214106_4925.0493.0Topological domainExtracellular
HgeneTMPRSS2chr21:42870046chr7:13971374ENST00000458356-2141_845.0493.0Topological domainCytoplasmic
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000332149-31485_10579.33333333333333493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42866282chr7:13950931ENST00000458356-31485_10579.33333333333333493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000332149-31485_10579.33333333333333493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42866283chr7:13950932ENST00000458356-31485_10579.33333333333333493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870045chr7:13971373ENST00000332149-21485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870045chr7:13971373ENST00000398585-21485_10542.0530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870045chr7:13971373ENST00000458356-21485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870045chr7:13971374ENST00000332149-21485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870045chr7:13971374ENST00000398585-21485_10542.0530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870045chr7:13971374ENST00000458356-21485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870046chr7:13971374ENST00000332149-21485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870046chr7:13971374ENST00000398585-21485_10542.0530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneTMPRSS2chr21:42870046chr7:13971374ENST00000458356-21485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
TMPRSS2CLK1, HNRNPL, DCAF4, S, ACE2, STX7, SCD, PLP2, PLLP, MOSPD3, UPK2, SELK, C3orf52, IGFBP5, SEC22A, PLP1, CLN6, TMEM128, C14orf1, CFHR5, TMEM243, TMEM60, CXCL9, BNIP2, CNIH3, PGAP2, TMEM218, TMEM86A, CMTM7, ZFPL1, BMP10, TMEM79, SLC35A1, SFTPC, VAMP5, FAXDC2, STX8, NINJ2, CLEC7A, C2CD2L, CNIH2, BNIP3, DEFB103A, DEFB103B, TMEM11, C17orf62, TMEM86B, ADIPOQ, EDDM3B, BRICD5, PTTG1IP, PTCH1, ANKRD46, TMEM222, C1QL4, TMEM120B, FAM3C, TMEM229B, PLN, CTXN3, TNF, SMIM1, AQP1, TMPRSS2, DNASE2, MYO1C, PGRMC1, NDUFA4, ADAM10, CLGN, SEC16A, SPINT2, COCH, B4GAT1, XPOT, MYO1B, LANCL1, CALU, PLXNA2, GPC4, BANF1, CPD, CLPX, STC2, SLIT2, MYO1D, ERLIN2, BAG2, TFRC, HLA-A, TP53, RPN1, RPN2, GNAI2, APP, ITGB1, INSR, GLA, GPI, ITGAV, CTSD, APRT, IGF1R, MET, GNAI3, CLTA, CALM2, HLA-C, DLAT, HSPA5, LAMC1, LAMP1, IGF2R, PDIA4, P4HA1, HSP90B1, PVR, RPA2, ATP2A2, PFKL, CDH2, MSH3, RPA1, CALR, RPA3, LONP1, TGFBR1, DDOST, HADHA, ECE1, DNM2, FXR2, PLXNA3, ATP1B3, HADHB, SEC61A1, GNB1, NOMO3, PRKDC, TFAM, SLC7A5, PFKP, KIF23, FMR1, PTK7, ADAM15, CUL2, SCARB2, WRN, DSC3, ITIH4, GANAB, KARS, RCN1, SAFB, IMMT, HSD17B12, UBR4, QSOX2, RRM2B, MON2, YTHDF3, PABPN1, PLD3, PELP1, TTC13, CNNM3, IPO4, FAR1, GGH, ERLEC1, RBM33, DNAJA3, RBM14, PPP1R9B, SDF2, NEU1, GRWD1, AIF1L, NTPCR, FUCA2, EDEM3, RACGAP1, RAB18, TMEM106B, CHPF2, GNG12, DNAJB11, EGFL7, DDX20, ADAMTS1, LNPEP, ITM2B, MRPL11, HYOU1, AFG3L2, YTHDF2, SUPT16H, PDHX, IPO5, SAP18, HGS, SPTBN2, PLXNB2, ARPC3, ACTN4, TRIM13, PDCD6, MPDU1, SEC22B, ATP6AP2, STAM2, ARL6IP5, UFL1, SEC31A, STBD1, SMC2, SEC24A, SEC24B, ACSL3, CDK1, SRPR, SPTB, MTHFD1, ACTN1, ETFA, RAB6A, VDAC1, HMOX2, MYH10, DEK, ATP5C1, NAMPT, VDAC2, QARS, TUFM, SERPINH1, BCAP31, PSMD7, CLCN7, SLC25A1, YARS, EPPK1, RAB10, ABCE1, RHOA, CNBP, TPM4, SLC25A11, LMNB2, CKAP4, GOLGA3, TWF1, TRAP1, STX5, DDX39B, RAB3GAP1, PON2, PPA1, SEC23A, SEC23B, NDUFA9, ATP6V1F, INF2, ANO6, ACTBL2, MIA3, CDKAL1, KIAA0368, C19orf70, SLC25A24, HUWE1, MEGF8, KTN1, COMTD1, ANKLE2, VRK2, ZDHHC17, DNAH10, NUP93, MMGT1, TMEM199, ATPAF2, EMC1, PDZD8, NBEA, MOSPD2, PDCD6IP, SYNE2, UBXN4, CCDC47, LRRC59, C7orf55, DDRGK1, NGLY1, CDK5RAP3, CCDC115, CLCC1, OSBPL9, RBM15, CGRRF1, ESYT1, NDC1, EFHD1, OSBPL8, KIAA1715, LSG1, RAB1B, TMX1, GORASP2, SFXN1, XPO5, VEZT, JPH1, BIRC6, AAAS, TOMM22, DDX19A, SMPD4, TMOD3, EMC3, VAPA, CEP72, LARS, DPM3, DHCR7, UBA2, AASS, ATP6V1H, SLC25A13, STOML2, RAB21, MYO6, VDAC3, AUP1, SEC23IP,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TMPRSS2all structure
ETV1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TMPRSS2-ETV1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TMPRSS2-ETV1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTMPRSS2C0033578Prostatic Neoplasms4CTD_human
HgeneTMPRSS2C0376358Malignant neoplasm of prostate4CTD_human
TgeneETV1C0033578Prostatic Neoplasms3CTD_human
TgeneETV1C0376358Malignant neoplasm of prostate3CTD_human
TgeneETV1C0009402Colorectal Carcinoma1CTD_human
TgeneETV1C0009404Colorectal Neoplasms1CTD_human