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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TMTC1-CASC1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TMTC1-CASC1
	FusionPDB ID: 92498
	FusionGDB2.0 ID: 92498
		Hgene	Tgene
	Gene symbol	TMTC1	CASC1
	Gene ID	83857	55259
	Gene name	transmembrane O-mannosyltransferase targeting cadherins 1	cancer susceptibility 1
	Synonyms	ARG99\|OLF\|TMTC1A	LAS1\|PPP1R54
	Cytomap	12p11.22	12p12.1
	Type of gene	protein-coding	protein-coding
	Description	protein O-mannosyl-transferase TMTC1transmembrane and tetratricopeptide repeat containing 1transmembrane and tetratricopeptide repeat containing 1A	protein CASC1cancer susceptibility candidate 1cancer susceptibility candidate gene 1 proteinlung adenoma susceptibility 1-like proteinprotein phosphatase 1 regulatory subunit 54
	Modification date	20200313	20200320
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000256062, ENST00000539277, ENST00000551659, ENST00000552618, ENST00000319685, ENST00000381224,	ENST00000557684, ENST00000320267, ENST00000354189, ENST00000395987, ENST00000395990, ENST00000537577, ENST00000545133,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	12 X 13 X 6=936	6 X 4 X 4=96
	# samples	13	7
	** MAII score	log2(13/936*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TMTC1 [Title/Abstract] AND CASC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TMTC1(29664976)-CASC1(25264873), # samples:3
Anticipated loss of major functional domain due to fusion event.	TMTC1-CASC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TMTC1-CASC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TMTC1-CASC1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. TMTC1-CASC1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TMTC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CASC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-DU-7007-01A	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-
ChimerDB4	LGG	TCGA-DU-7007	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-
ChimerDB4	LGG	TCGA-DU-7007	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000551659	TMTC1	chr12	29664976	-	ENST00000354189	CASC1	chr12	25264873	-	3464	2840	26	3127	1033
ENST00000551659	TMTC1	chr12	29664976	-	ENST00000395987	CASC1	chr12	25264873	-	3526	2840	26	3397	1123
ENST00000551659	TMTC1	chr12	29664976	-	ENST00000395990	CASC1	chr12	25264873	-	3526	2840	26	3397	1123
ENST00000551659	TMTC1	chr12	29664976	-	ENST00000320267	CASC1	chr12	25264873	-	3526	2840	26	3397	1123
ENST00000551659	TMTC1	chr12	29664976	-	ENST00000537577	CASC1	chr12	25264873	-	3463	2840	26	3127	1033
ENST00000551659	TMTC1	chr12	29664976	-	ENST00000545133	CASC1	chr12	25264873	-	3522	2840	26	3397	1123
ENST00000552618	TMTC1	chr12	29664976	-	ENST00000354189	CASC1	chr12	25264873	-	3251	2627	47	2914	955
ENST00000552618	TMTC1	chr12	29664976	-	ENST00000395987	CASC1	chr12	25264873	-	3313	2627	47	3184	1045
ENST00000552618	TMTC1	chr12	29664976	-	ENST00000395990	CASC1	chr12	25264873	-	3313	2627	47	3184	1045
ENST00000552618	TMTC1	chr12	29664976	-	ENST00000320267	CASC1	chr12	25264873	-	3313	2627	47	3184	1045
ENST00000552618	TMTC1	chr12	29664976	-	ENST00000537577	CASC1	chr12	25264873	-	3250	2627	47	2914	955
ENST00000552618	TMTC1	chr12	29664976	-	ENST00000545133	CASC1	chr12	25264873	-	3309	2627	47	3184	1045
ENST00000539277	TMTC1	chr12	29664976	-	ENST00000354189	CASC1	chr12	25264873	-	3191	2567	59	2854	931
ENST00000539277	TMTC1	chr12	29664976	-	ENST00000395987	CASC1	chr12	25264873	-	3253	2567	59	3124	1021
ENST00000539277	TMTC1	chr12	29664976	-	ENST00000395990	CASC1	chr12	25264873	-	3253	2567	59	3124	1021
ENST00000539277	TMTC1	chr12	29664976	-	ENST00000320267	CASC1	chr12	25264873	-	3253	2567	59	3124	1021
ENST00000539277	TMTC1	chr12	29664976	-	ENST00000537577	CASC1	chr12	25264873	-	3190	2567	59	2854	931
ENST00000539277	TMTC1	chr12	29664976	-	ENST00000545133	CASC1	chr12	25264873	-	3249	2567	59	3124	1021
ENST00000551659	TMTC1	chr12	29664975	-	ENST00000354189	CASC1	chr12	25264873	-	3464	2840	26	3127	1033
ENST00000551659	TMTC1	chr12	29664975	-	ENST00000395987	CASC1	chr12	25264873	-	3526	2840	26	3397	1123
ENST00000551659	TMTC1	chr12	29664975	-	ENST00000395990	CASC1	chr12	25264873	-	3526	2840	26	3397	1123
ENST00000551659	TMTC1	chr12	29664975	-	ENST00000320267	CASC1	chr12	25264873	-	3526	2840	26	3397	1123
ENST00000551659	TMTC1	chr12	29664975	-	ENST00000537577	CASC1	chr12	25264873	-	3463	2840	26	3127	1033
ENST00000551659	TMTC1	chr12	29664975	-	ENST00000545133	CASC1	chr12	25264873	-	3522	2840	26	3397	1123
ENST00000552618	TMTC1	chr12	29664975	-	ENST00000354189	CASC1	chr12	25264873	-	3251	2627	47	2914	955
ENST00000552618	TMTC1	chr12	29664975	-	ENST00000395987	CASC1	chr12	25264873	-	3313	2627	47	3184	1045
ENST00000552618	TMTC1	chr12	29664975	-	ENST00000395990	CASC1	chr12	25264873	-	3313	2627	47	3184	1045
ENST00000552618	TMTC1	chr12	29664975	-	ENST00000320267	CASC1	chr12	25264873	-	3313	2627	47	3184	1045
ENST00000552618	TMTC1	chr12	29664975	-	ENST00000537577	CASC1	chr12	25264873	-	3250	2627	47	2914	955
ENST00000552618	TMTC1	chr12	29664975	-	ENST00000545133	CASC1	chr12	25264873	-	3309	2627	47	3184	1045
ENST00000539277	TMTC1	chr12	29664975	-	ENST00000354189	CASC1	chr12	25264873	-	3191	2567	59	2854	931
ENST00000539277	TMTC1	chr12	29664975	-	ENST00000395987	CASC1	chr12	25264873	-	3253	2567	59	3124	1021
ENST00000539277	TMTC1	chr12	29664975	-	ENST00000395990	CASC1	chr12	25264873	-	3253	2567	59	3124	1021
ENST00000539277	TMTC1	chr12	29664975	-	ENST00000320267	CASC1	chr12	25264873	-	3253	2567	59	3124	1021
ENST00000539277	TMTC1	chr12	29664975	-	ENST00000537577	CASC1	chr12	25264873	-	3190	2567	59	2854	931
ENST00000539277	TMTC1	chr12	29664975	-	ENST00000545133	CASC1	chr12	25264873	-	3249	2567	59	3124	1021

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000551659	ENST00000354189	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-	0.002721204	0.99727887
ENST00000551659	ENST00000395987	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-	0.00137976	0.9986203
ENST00000551659	ENST00000395990	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-	0.00137976	0.9986203
ENST00000551659	ENST00000320267	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-	0.00137976	0.9986203
ENST00000551659	ENST00000537577	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-	0.002711548	0.99728847
ENST00000551659	ENST00000545133	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-	0.001364901	0.9986351
ENST00000552618	ENST00000354189	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-	0.002916629	0.99708337
ENST00000552618	ENST00000395987	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-	0.001585102	0.9984149
ENST00000552618	ENST00000395990	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-	0.001585102	0.9984149
ENST00000552618	ENST00000320267	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-	0.001585102	0.9984149
ENST00000552618	ENST00000537577	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-	0.002900061	0.9971
ENST00000552618	ENST00000545133	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-	0.001560016	0.99843997
ENST00000539277	ENST00000354189	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-	0.003855041	0.9961449
ENST00000539277	ENST00000395987	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-	0.001654658	0.9983454
ENST00000539277	ENST00000395990	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-	0.001654658	0.9983454
ENST00000539277	ENST00000320267	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-	0.001654658	0.9983454
ENST00000539277	ENST00000537577	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-	0.003844037	0.9961559
ENST00000539277	ENST00000545133	TMTC1	chr12	29664976	-	CASC1	chr12	25264873	-	0.0016359	0.99836415
ENST00000551659	ENST00000354189	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-	0.002721204	0.99727887
ENST00000551659	ENST00000395987	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-	0.00137976	0.9986203
ENST00000551659	ENST00000395990	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-	0.00137976	0.9986203
ENST00000551659	ENST00000320267	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-	0.00137976	0.9986203
ENST00000551659	ENST00000537577	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-	0.002711548	0.99728847
ENST00000551659	ENST00000545133	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-	0.001364901	0.9986351
ENST00000552618	ENST00000354189	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-	0.002916629	0.99708337
ENST00000552618	ENST00000395987	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-	0.001585102	0.9984149
ENST00000552618	ENST00000395990	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-	0.001585102	0.9984149
ENST00000552618	ENST00000320267	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-	0.001585102	0.9984149
ENST00000552618	ENST00000537577	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-	0.002900061	0.9971
ENST00000552618	ENST00000545133	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-	0.001560016	0.99843997
ENST00000539277	ENST00000354189	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-	0.003855041	0.9961449
ENST00000539277	ENST00000395987	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-	0.001654658	0.9983454
ENST00000539277	ENST00000395990	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-	0.001654658	0.9983454
ENST00000539277	ENST00000320267	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-	0.001654658	0.9983454
ENST00000539277	ENST00000537577	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-	0.003844037	0.9961559
ENST00000539277	ENST00000545133	TMTC1	chr12	29664975	-	CASC1	chr12	25264873	-	0.0016359	0.99836415

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>92498_92498_1_TMTC1-CASC1_TMTC1_chr12_29664975_ENST00000539277_CASC1_chr12_25264873_ENST00000320267_length(amino acids)=1021AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFL
AVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLL
LLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRA
LQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTG
LPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELR
LALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFE
SYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKA
YRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFHSTLYHMVKDFAS

--------------------------------------------------------------

>92498_92498_2_TMTC1-CASC1_TMTC1_chr12_29664975_ENST00000539277_CASC1_chr12_25264873_ENST00000354189_length(amino acids)=931AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFL
AVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLL
LLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRA
LQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTG
LPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELR
LALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFE
SYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKA

--------------------------------------------------------------

>92498_92498_3_TMTC1-CASC1_TMTC1_chr12_29664975_ENST00000539277_CASC1_chr12_25264873_ENST00000395987_length(amino acids)=1021AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFL
AVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLL
LLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRA
LQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTG
LPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELR
LALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFE
SYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKA
YRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFHSTLYHMVKDFAS

--------------------------------------------------------------

>92498_92498_4_TMTC1-CASC1_TMTC1_chr12_29664975_ENST00000539277_CASC1_chr12_25264873_ENST00000395990_length(amino acids)=1021AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFL
AVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLL
LLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRA
LQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTG
LPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELR
LALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFE
SYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKA
YRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFHSTLYHMVKDFAS

--------------------------------------------------------------

>92498_92498_5_TMTC1-CASC1_TMTC1_chr12_29664975_ENST00000539277_CASC1_chr12_25264873_ENST00000537577_length(amino acids)=931AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFL
AVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLL
LLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRA
LQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTG
LPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELR
LALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFE
SYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKA

--------------------------------------------------------------

>92498_92498_6_TMTC1-CASC1_TMTC1_chr12_29664975_ENST00000539277_CASC1_chr12_25264873_ENST00000545133_length(amino acids)=1021AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFL
AVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLL
LLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRA
LQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTG
LPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELR
LALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFE
SYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKA
YRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFHSTLYHMVKDFAS

--------------------------------------------------------------

>92498_92498_7_TMTC1-CASC1_TMTC1_chr12_29664975_ENST00000551659_CASC1_chr12_25264873_ENST00000320267_length(amino acids)=1123AA_BP=66
MPQHHARAPLRADAARRRGPGRGGCQTPGRGQGSSGGGGAMVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFV
HDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHKSYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKN
RGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCL
VYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSN
RNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVET
IWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRC
GATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR
DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDL
HNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQE
AAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQ
LREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVI
INNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFH

--------------------------------------------------------------

>92498_92498_8_TMTC1-CASC1_TMTC1_chr12_29664975_ENST00000551659_CASC1_chr12_25264873_ENST00000354189_length(amino acids)=1033AA_BP=66
MPQHHARAPLRADAARRRGPGRGGCQTPGRGQGSSGGGGAMVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFV
HDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHKSYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKN
RGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCL
VYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSN
RNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVET
IWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRC
GATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR
DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDL
HNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQE
AAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQ
LREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVI

--------------------------------------------------------------

>92498_92498_9_TMTC1-CASC1_TMTC1_chr12_29664975_ENST00000551659_CASC1_chr12_25264873_ENST00000395987_length(amino acids)=1123AA_BP=66
MPQHHARAPLRADAARRRGPGRGGCQTPGRGQGSSGGGGAMVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFV
HDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHKSYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKN
RGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCL
VYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSN
RNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVET
IWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRC
GATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR
DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDL
HNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQE
AAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQ
LREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVI
INNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFH

--------------------------------------------------------------

>92498_92498_10_TMTC1-CASC1_TMTC1_chr12_29664975_ENST00000551659_CASC1_chr12_25264873_ENST00000395990_length(amino acids)=1123AA_BP=66
MPQHHARAPLRADAARRRGPGRGGCQTPGRGQGSSGGGGAMVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFV
HDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHKSYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKN
RGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCL
VYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSN
RNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVET
IWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRC
GATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR
DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDL
HNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQE
AAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQ
LREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVI
INNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFH

--------------------------------------------------------------

>92498_92498_11_TMTC1-CASC1_TMTC1_chr12_29664975_ENST00000551659_CASC1_chr12_25264873_ENST00000537577_length(amino acids)=1033AA_BP=66
MPQHHARAPLRADAARRRGPGRGGCQTPGRGQGSSGGGGAMVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFV
HDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHKSYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKN
RGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCL
VYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSN
RNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVET
IWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRC
GATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR
DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDL
HNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQE
AAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQ
LREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVI

--------------------------------------------------------------

>92498_92498_12_TMTC1-CASC1_TMTC1_chr12_29664975_ENST00000551659_CASC1_chr12_25264873_ENST00000545133_length(amino acids)=1123AA_BP=66
MPQHHARAPLRADAARRRGPGRGGCQTPGRGQGSSGGGGAMVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFV
HDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHKSYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKN
RGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCL
VYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSN
RNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVET
IWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRC
GATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR
DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDL
HNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQE
AAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQ
LREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVI
INNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFH

--------------------------------------------------------------

>92498_92498_13_TMTC1-CASC1_TMTC1_chr12_29664975_ENST00000552618_CASC1_chr12_25264873_ENST00000320267_length(amino acids)=1045AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSNRNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFS
EQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLL
FLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRLYPRH
ASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQ
TGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNT
GRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPK
VISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLN
IFPTRHSHFYVIINNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEA

--------------------------------------------------------------

>92498_92498_14_TMTC1-CASC1_TMTC1_chr12_29664975_ENST00000552618_CASC1_chr12_25264873_ENST00000354189_length(amino acids)=955AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSNRNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFS
EQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLL
FLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRLYPRH
ASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQ
TGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNT
GRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPK
VISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLN

--------------------------------------------------------------

>92498_92498_15_TMTC1-CASC1_TMTC1_chr12_29664975_ENST00000552618_CASC1_chr12_25264873_ENST00000395987_length(amino acids)=1045AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSNRNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFS
EQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLL
FLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRLYPRH
ASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQ
TGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNT
GRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPK
VISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLN
IFPTRHSHFYVIINNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEA

--------------------------------------------------------------

>92498_92498_16_TMTC1-CASC1_TMTC1_chr12_29664975_ENST00000552618_CASC1_chr12_25264873_ENST00000395990_length(amino acids)=1045AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSNRNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFS
EQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLL
FLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRLYPRH
ASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQ
TGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNT
GRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPK
VISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLN
IFPTRHSHFYVIINNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEA

--------------------------------------------------------------

>92498_92498_17_TMTC1-CASC1_TMTC1_chr12_29664975_ENST00000552618_CASC1_chr12_25264873_ENST00000537577_length(amino acids)=955AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSNRNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFS
EQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLL
FLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRLYPRH
ASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQ
TGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNT
GRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPK
VISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLN

--------------------------------------------------------------

>92498_92498_18_TMTC1-CASC1_TMTC1_chr12_29664975_ENST00000552618_CASC1_chr12_25264873_ENST00000545133_length(amino acids)=1045AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSNRNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFS
EQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLL
FLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRLYPRH
ASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQ
TGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNT
GRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPK
VISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLN
IFPTRHSHFYVIINNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEA

--------------------------------------------------------------

>92498_92498_19_TMTC1-CASC1_TMTC1_chr12_29664976_ENST00000539277_CASC1_chr12_25264873_ENST00000320267_length(amino acids)=1021AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFL
AVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLL
LLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRA
LQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTG
LPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELR
LALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFE
SYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKA
YRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFHSTLYHMVKDFAS

--------------------------------------------------------------

>92498_92498_20_TMTC1-CASC1_TMTC1_chr12_29664976_ENST00000539277_CASC1_chr12_25264873_ENST00000354189_length(amino acids)=931AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFL
AVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLL
LLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRA
LQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTG
LPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELR
LALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFE
SYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKA

--------------------------------------------------------------

>92498_92498_21_TMTC1-CASC1_TMTC1_chr12_29664976_ENST00000539277_CASC1_chr12_25264873_ENST00000395987_length(amino acids)=1021AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFL
AVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLL
LLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRA
LQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTG
LPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELR
LALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFE
SYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKA
YRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFHSTLYHMVKDFAS

--------------------------------------------------------------

>92498_92498_22_TMTC1-CASC1_TMTC1_chr12_29664976_ENST00000539277_CASC1_chr12_25264873_ENST00000395990_length(amino acids)=1021AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFL
AVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLL
LLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRA
LQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTG
LPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELR
LALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFE
SYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKA
YRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFHSTLYHMVKDFAS

--------------------------------------------------------------

>92498_92498_23_TMTC1-CASC1_TMTC1_chr12_29664976_ENST00000539277_CASC1_chr12_25264873_ENST00000537577_length(amino acids)=931AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFL
AVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLL
LLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRA
LQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTG
LPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELR
LALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFE
SYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKA

--------------------------------------------------------------

>92498_92498_24_TMTC1-CASC1_TMTC1_chr12_29664976_ENST00000539277_CASC1_chr12_25264873_ENST00000545133_length(amino acids)=1021AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFL
AVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLL
LLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRA
LQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTG
LPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELR
LALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFE
SYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKA
YRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFHSTLYHMVKDFAS

--------------------------------------------------------------

>92498_92498_25_TMTC1-CASC1_TMTC1_chr12_29664976_ENST00000551659_CASC1_chr12_25264873_ENST00000320267_length(amino acids)=1123AA_BP=66
MPQHHARAPLRADAARRRGPGRGGCQTPGRGQGSSGGGGAMVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFV
HDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHKSYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKN
RGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCL
VYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSN
RNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVET
IWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRC
GATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR
DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDL
HNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQE
AAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQ
LREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVI
INNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFH

--------------------------------------------------------------

>92498_92498_26_TMTC1-CASC1_TMTC1_chr12_29664976_ENST00000551659_CASC1_chr12_25264873_ENST00000354189_length(amino acids)=1033AA_BP=66
MPQHHARAPLRADAARRRGPGRGGCQTPGRGQGSSGGGGAMVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFV
HDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHKSYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKN
RGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCL
VYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSN
RNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVET
IWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRC
GATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR
DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDL
HNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQE
AAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQ
LREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVI

--------------------------------------------------------------

>92498_92498_27_TMTC1-CASC1_TMTC1_chr12_29664976_ENST00000551659_CASC1_chr12_25264873_ENST00000395987_length(amino acids)=1123AA_BP=66
MPQHHARAPLRADAARRRGPGRGGCQTPGRGQGSSGGGGAMVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFV
HDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHKSYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKN
RGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCL
VYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSN
RNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVET
IWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRC
GATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR
DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDL
HNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQE
AAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQ
LREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVI
INNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFH

--------------------------------------------------------------

>92498_92498_28_TMTC1-CASC1_TMTC1_chr12_29664976_ENST00000551659_CASC1_chr12_25264873_ENST00000395990_length(amino acids)=1123AA_BP=66
MPQHHARAPLRADAARRRGPGRGGCQTPGRGQGSSGGGGAMVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFV
HDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHKSYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKN
RGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCL
VYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSN
RNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVET
IWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRC
GATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR
DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDL
HNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQE
AAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQ
LREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVI
INNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFH

--------------------------------------------------------------

>92498_92498_29_TMTC1-CASC1_TMTC1_chr12_29664976_ENST00000551659_CASC1_chr12_25264873_ENST00000537577_length(amino acids)=1033AA_BP=66
MPQHHARAPLRADAARRRGPGRGGCQTPGRGQGSSGGGGAMVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFV
HDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHKSYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKN
RGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCL
VYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSN
RNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVET
IWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRC
GATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR
DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDL
HNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQE
AAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQ
LREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVI

--------------------------------------------------------------

>92498_92498_30_TMTC1-CASC1_TMTC1_chr12_29664976_ENST00000551659_CASC1_chr12_25264873_ENST00000545133_length(amino acids)=1123AA_BP=66
MPQHHARAPLRADAARRRGPGRGGCQTPGRGQGSSGGGGAMVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFV
HDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHKSYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKN
RGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCL
VYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSN
RNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVET
IWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRC
GATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR
DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDL
HNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQE
AAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQ
LREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVI
INNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFH

--------------------------------------------------------------

>92498_92498_31_TMTC1-CASC1_TMTC1_chr12_29664976_ENST00000552618_CASC1_chr12_25264873_ENST00000320267_length(amino acids)=1045AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSNRNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFS
EQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLL
FLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRLYPRH
ASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQ
TGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNT
GRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPK
VISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLN
IFPTRHSHFYVIINNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEA

--------------------------------------------------------------

>92498_92498_32_TMTC1-CASC1_TMTC1_chr12_29664976_ENST00000552618_CASC1_chr12_25264873_ENST00000354189_length(amino acids)=955AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSNRNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFS
EQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLL
FLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRLYPRH
ASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQ
TGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNT
GRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPK
VISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLN

--------------------------------------------------------------

>92498_92498_33_TMTC1-CASC1_TMTC1_chr12_29664976_ENST00000552618_CASC1_chr12_25264873_ENST00000395987_length(amino acids)=1045AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSNRNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFS
EQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLL
FLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRLYPRH
ASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQ
TGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNT
GRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPK
VISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLN
IFPTRHSHFYVIINNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEA

--------------------------------------------------------------

>92498_92498_34_TMTC1-CASC1_TMTC1_chr12_29664976_ENST00000552618_CASC1_chr12_25264873_ENST00000395990_length(amino acids)=1045AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSNRNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFS
EQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLL
FLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRLYPRH
ASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQ
TGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNT
GRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPK
VISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLN
IFPTRHSHFYVIINNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEA

--------------------------------------------------------------

>92498_92498_35_TMTC1-CASC1_TMTC1_chr12_29664976_ENST00000552618_CASC1_chr12_25264873_ENST00000537577_length(amino acids)=955AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSNRNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFS
EQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLL
FLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRLYPRH
ASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQ
TGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNT
GRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPK
VISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLN

--------------------------------------------------------------

>92498_92498_36_TMTC1-CASC1_TMTC1_chr12_29664976_ENST00000552618_CASC1_chr12_25264873_ENST00000545133_length(amino acids)=1045AA_BP=26
MVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFVHDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHK
SYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAF
LSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPH
RENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSNRNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFS
EQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLL
FLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRLYPRH
ASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQ
TGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNT
GRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPK
VISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLN
IFPTRHSHFYVIINNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEA

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:29664976/chr12:25264873)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

483_516

728.0

775.0

Repeat

Note=TPR 1

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

518_547

728.0

775.0

Repeat

Note=TPR 2

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

548_581

728.0

775.0

Repeat

Note=TPR 3

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

583_615

728.0

775.0

Repeat

Note=TPR 4

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

616_649

728.0

775.0

Repeat

Note=TPR 5

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

650_683

728.0

775.0

Repeat

Note=TPR 6

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

684_716

728.0

775.0

Repeat

Note=TPR 7

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

483_516

836.0

883.0

Repeat

Note=TPR 1

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

518_547

836.0

883.0

Repeat

Note=TPR 2

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

548_581

836.0

883.0

Repeat

Note=TPR 3

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

583_615

836.0

883.0

Repeat

Note=TPR 4

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

616_649

836.0

883.0

Repeat

Note=TPR 5

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

650_683

836.0

883.0

Repeat

Note=TPR 6

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

684_716

836.0

883.0

Repeat

Note=TPR 7

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

751_784

836.0

883.0

Repeat

Note=TPR 8

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

789_822

836.0

883.0

Repeat

Note=TPR 9

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

483_516

728.0

775.0

Repeat

Note=TPR 1

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

518_547

728.0

775.0

Repeat

Note=TPR 2

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

548_581

728.0

775.0

Repeat

Note=TPR 3

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

583_615

728.0

775.0

Repeat

Note=TPR 4

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

616_649

728.0

775.0

Repeat

Note=TPR 5

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

650_683

728.0

775.0

Repeat

Note=TPR 6

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

684_716

728.0

775.0

Repeat

Note=TPR 7

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

483_516

836.0

883.0

Repeat

Note=TPR 1

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

518_547

836.0

883.0

Repeat

Note=TPR 2

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

548_581

836.0

883.0

Repeat

Note=TPR 3

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

583_615

836.0

883.0

Repeat

Note=TPR 4

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

616_649

836.0

883.0

Repeat

Note=TPR 5

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

650_683

836.0

883.0

Repeat

Note=TPR 6

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

684_716

836.0

883.0

Repeat

Note=TPR 7

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

751_784

836.0

883.0

Repeat

Note=TPR 8

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

789_822

836.0

883.0

Repeat

Note=TPR 9

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

111_131

728.0

775.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

161_181

728.0

775.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

198_218

728.0

775.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

21_41

728.0

775.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

314_334

728.0

775.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

355_375

728.0

775.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

382_402

728.0

775.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

404_424

728.0

775.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

439_459

728.0

775.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

111_131

836.0

883.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

161_181

836.0

883.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

198_218

836.0

883.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

21_41

836.0

883.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

314_334

836.0

883.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

355_375

836.0

883.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

382_402

836.0

883.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

404_424

836.0

883.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

439_459

836.0

883.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

111_131

728.0

775.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

161_181

728.0

775.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

198_218

728.0

775.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

21_41

728.0

775.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

314_334

728.0

775.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

355_375

728.0

775.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

382_402

728.0

775.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

404_424

728.0

775.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

439_459

728.0

775.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

111_131

836.0

883.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

161_181

836.0

883.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

198_218

836.0

883.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

21_41

836.0

883.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

314_334

836.0

883.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

355_375

836.0

883.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

382_402

836.0

883.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

404_424

836.0

883.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

439_459

836.0

883.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

751_784

728.0

775.0

Repeat

Note=TPR 8

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

789_822

728.0

775.0

Repeat

Note=TPR 9

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000256062

823_856

728.0

775.0

Repeat

Note=TPR 10

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

483_516

575.0

Repeat

Note=TPR 1

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

518_547

575.0

Repeat

Note=TPR 2

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

548_581

575.0

Repeat

Note=TPR 3

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

583_615

575.0

Repeat

Note=TPR 4

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

616_649

575.0

Repeat

Note=TPR 5

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

650_683

575.0

Repeat

Note=TPR 6

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

684_716

575.0

Repeat

Note=TPR 7

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

751_784

575.0

Repeat

Note=TPR 8

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

789_822

575.0

Repeat

Note=TPR 9

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

823_856

575.0

Repeat

Note=TPR 10

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000539277

823_856

836.0

883.0

Repeat

Note=TPR 10

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

751_784

728.0

775.0

Repeat

Note=TPR 8

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

789_822

728.0

775.0

Repeat

Note=TPR 9

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000256062

823_856

728.0

775.0

Repeat

Note=TPR 10

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

483_516

575.0

Repeat

Note=TPR 1

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

518_547

575.0

Repeat

Note=TPR 2

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

548_581

575.0

Repeat

Note=TPR 3

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

583_615

575.0

Repeat

Note=TPR 4

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

616_649

575.0

Repeat

Note=TPR 5

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

650_683

575.0

Repeat

Note=TPR 6

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

684_716

575.0

Repeat

Note=TPR 7

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

751_784

575.0

Repeat

Note=TPR 8

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

789_822

575.0

Repeat

Note=TPR 9

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

823_856

575.0

Repeat

Note=TPR 10

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000539277

823_856

836.0

883.0

Repeat

Note=TPR 10

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

111_131

575.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

161_181

575.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

198_218

575.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

21_41

575.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

314_334

575.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

355_375

575.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

382_402

575.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

404_424

575.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664975

chr12:25264873

ENST00000381224

439_459

575.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

111_131

575.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

161_181

575.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

198_218

575.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

21_41

575.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

314_334

575.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

355_375

575.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

382_402

575.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

404_424

575.0

Transmembrane

Helical

Hgene

TMTC1

chr12:29664976

chr12:25264873

ENST00000381224

439_459

575.0

Transmembrane

Helical

Tgene

CASC1

chr12:29664975

chr12:25264873

ENST00000320267

20_88

531.0

717.0

Compositional bias

Note=Glu-rich

Tgene

CASC1

chr12:29664975

chr12:25264873

ENST00000320267

5_8

531.0

717.0

Compositional bias

Note=Poly-Lys

Tgene

CASC1

chr12:29664975

chr12:25264873

ENST00000354189

20_88

595.0

691.0

Compositional bias

Note=Glu-rich

Tgene

CASC1

chr12:29664975

chr12:25264873

ENST00000354189

5_8

595.0

691.0

Compositional bias

Note=Poly-Lys

Tgene

CASC1

chr12:29664975

chr12:25264873

ENST00000395990

20_88

491.0

677.0

Compositional bias

Note=Glu-rich

Tgene

CASC1

chr12:29664975

chr12:25264873

ENST00000395990

5_8

491.0

677.0

Compositional bias

Note=Poly-Lys

Tgene

CASC1

chr12:29664975

chr12:25264873

ENST00000545133

20_88

472.0

658.0

Compositional bias

Note=Glu-rich

Tgene

CASC1

chr12:29664975

chr12:25264873

ENST00000545133

5_8

472.0

658.0

Compositional bias

Note=Poly-Lys

Tgene

CASC1

chr12:29664976

chr12:25264873

ENST00000320267

20_88

531.0

717.0

Compositional bias

Note=Glu-rich

Tgene

CASC1

chr12:29664976

chr12:25264873

ENST00000320267

5_8

531.0

717.0

Compositional bias

Note=Poly-Lys

Tgene

CASC1

chr12:29664976

chr12:25264873

ENST00000354189

20_88

595.0

691.0

Compositional bias

Note=Glu-rich

Tgene

CASC1

chr12:29664976

chr12:25264873

ENST00000354189

5_8

595.0

691.0

Compositional bias

Note=Poly-Lys

Tgene

CASC1

chr12:29664976

chr12:25264873

ENST00000395990

20_88

491.0

677.0

Compositional bias

Note=Glu-rich

Tgene

CASC1

chr12:29664976

chr12:25264873

ENST00000395990

5_8

491.0

677.0

Compositional bias

Note=Poly-Lys

Tgene

CASC1

chr12:29664976

chr12:25264873

ENST00000545133

20_88

472.0

658.0

Compositional bias

Note=Glu-rich

Tgene

CASC1

chr12:29664976

chr12:25264873

ENST00000545133

5_8

472.0

658.0

Compositional bias

Note=Poly-Lys

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1875_TMTC1_29664976_CASC1_25264873_ranked_0.pdb	TMTC1	29664975	29664976	ENST00000545133	CASC1	chr12	25264873	-	MPQHHARAPLRADAARRRGPGRGGCQTPGRGQGSSGGGGAMVVTTSARGGGGDRTPSRRRGCGLAPAGAAALLAGASCLCYGRSLQGEFV HDDVWAIVNNPDVRPGAPLRWGIFTNDFWGKGMAENTSHKSYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKN RGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCL VYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSN RNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVET IWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRC GATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDL HNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQE AAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQ LREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVI INNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFH	1123

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

TMTC1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TMTC1
CASC1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to TMTC1-CASC1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to TMTC1-CASC1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source