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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TNKS2-PDCD4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TNKS2-PDCD4
FusionPDB ID: 92739
FusionGDB2.0 ID: 92739
HgeneTgene
Gene symbol

TNKS2

PDCD4

Gene ID

80351

27250

Gene nametankyrase 2programmed cell death 4
SynonymsARTD6|PARP-5b|PARP-5c|PARP5B|PARP5C|TANK2|TNKL|pART6H731
Cytomap

10q23.32

10q25.2

Type of geneprotein-codingprotein-coding
Descriptionpoly [ADP-ribose] polymerase tankyrase-2ADP-ribosyltransferase diphtheria toxin-like 6TNKS-2TRF1-interacting ankyrin-related ADP-ribose polymerase 2poly [ADP-ribose] polymerase 5Bprotein poly-ADP-ribosyltransferase tankyrase-2tankyrase IItankyrase,programmed cell death protein 4neoplastic transformation inhibitor proteinnuclear antigen H731programmed cell death 4 (neoplastic transformation inhibitor)protein 197/15a
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000371627, ENST00000481353, 
ENST00000280154, ENST00000393104, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 8 X 4=3205 X 6 X 5=150
# samples 106
** MAII scorelog2(10/320*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TNKS2 [Title/Abstract] AND PDCD4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TNKS2(93617287)-PDCD4(112640990), # samples:2
Anticipated loss of major functional domain due to fusion event.TNKS2-PDCD4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TNKS2-PDCD4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TNKS2-PDCD4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TNKS2-PDCD4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNKS2

GO:0000209

protein polyubiquitination

19759537|21478859

HgeneTNKS2

GO:0006471

protein ADP-ribosylation

11739745

HgeneTNKS2

GO:0070212

protein poly-ADP-ribosylation

25043379

HgeneTNKS2

GO:0070213

protein auto-ADP-ribosylation

19759537|21478859

HgeneTNKS2

GO:1904355

positive regulation of telomere capping

21531765

TgenePDCD4

GO:0007569

cell aging

12054647

TgenePDCD4

GO:0030509

BMP signaling pathway

18548003

TgenePDCD4

GO:0045892

negative regulation of transcription, DNA-templated

16357133

TgenePDCD4

GO:1905064

negative regulation of vascular smooth muscle cell differentiation

18548003


check buttonFusion gene breakpoints across TNKS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDCD4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8381TNKS2chr10

93617287

+PDCD4chr10

112640990

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371627TNKS2chr1093617287+ENST00000280154PDCD4chr10112640990+675834739448391581
ENST00000371627TNKS2chr1093617287+ENST00000393104PDCD4chr10112640990+675734739448391581

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371627ENST00000280154TNKS2chr1093617287+PDCD4chr10112640990+0.0002633780.9997366
ENST00000371627ENST00000393104TNKS2chr1093617287+PDCD4chr10112640990+0.0002632070.9997367

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>92739_92739_1_TNKS2-PDCD4_TNKS2_chr10_93617287_ENST00000371627_PDCD4_chr10_112640990_ENST00000280154_length(amino acids)=1581AA_BP=1126
MAGGALPASAAASFQDPDGGFALPPPPRGSRGAGSPARGARGRGHGTAPDPVTAGSQAARALSASSPGGLALLLAGPGLLLRLLALLLAV
AAARIMSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ
ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGE
YKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK
HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM
VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH
LQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAG
YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG
NTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIP
LHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPS
CYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFE
REQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHA
GGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHDPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAK
AKRRLRKNSSRDSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQE
NCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEK
SFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLV
KEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLD

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>92739_92739_2_TNKS2-PDCD4_TNKS2_chr10_93617287_ENST00000371627_PDCD4_chr10_112640990_ENST00000393104_length(amino acids)=1581AA_BP=1126
MAGGALPASAAASFQDPDGGFALPPPPRGSRGAGSPARGARGRGHGTAPDPVTAGSQAARALSASSPGGLALLLAGPGLLLRLLALLLAV
AAARIMSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ
ARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGE
YKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK
HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM
VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH
LQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAG
YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG
NTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIP
LHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPS
CYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFE
REQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHA
GGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHDPDNLSDSLFSGDEENAGTEEIKNEINGNWISASSINEARINAK
AKRRLRKNSSRDSGRGDSVSDSGSDALRSGLTVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQE
NCVYETVVLPLDERAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTTDVEK
SFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQSVNHLV
KEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIIMVLESTGESTFKMILDLLKSLWKSSTITVDQMKRGYERIYNEIPDINLD

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:93617287/chr10:112640990)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNKS2chr10:93617287chr10:112640990ENST00000371627+2427873_9361031.33333333333331167.0DomainSAM
HgeneTNKS2chr10:93617287chr10:112640990ENST00000371627+2427545_5531031.33333333333331167.0RegionHIF1AN-binding
HgeneTNKS2chr10:93617287chr10:112640990ENST00000371627+2427123_1551031.33333333333331167.0RepeatNote=ANK 3
HgeneTNKS2chr10:93617287chr10:112640990ENST00000371627+2427210_2421031.33333333333331167.0RepeatNote=ANK 4
HgeneTNKS2chr10:93617287chr10:112640990ENST00000371627+2427243_2751031.33333333333331167.0RepeatNote=ANK 5
HgeneTNKS2chr10:93617287chr10:112640990ENST00000371627+2427276_3081031.33333333333331167.0RepeatNote=ANK 6
HgeneTNKS2chr10:93617287chr10:112640990ENST00000371627+2427363_3981031.33333333333331167.0RepeatNote=ANK 7
HgeneTNKS2chr10:93617287chr10:112640990ENST00000371627+2427399_4311031.33333333333331167.0RepeatNote=ANK 8
HgeneTNKS2chr10:93617287chr10:112640990ENST00000371627+2427432_4641031.33333333333331167.0RepeatNote=ANK 9
HgeneTNKS2chr10:93617287chr10:112640990ENST00000371627+2427525_5571031.33333333333331167.0RepeatNote=ANK 10
HgeneTNKS2chr10:93617287chr10:112640990ENST00000371627+2427558_5901031.33333333333331167.0RepeatNote=ANK 11
HgeneTNKS2chr10:93617287chr10:112640990ENST00000371627+242757_891031.33333333333331167.0RepeatNote=ANK 1
HgeneTNKS2chr10:93617287chr10:112640990ENST00000371627+2427591_6231031.33333333333331167.0RepeatNote=ANK 12
HgeneTNKS2chr10:93617287chr10:112640990ENST00000371627+2427678_7101031.33333333333331167.0RepeatNote=ANK 13
HgeneTNKS2chr10:93617287chr10:112640990ENST00000371627+2427711_7431031.33333333333331167.0RepeatNote=ANK 14
HgeneTNKS2chr10:93617287chr10:112640990ENST00000371627+2427744_7761031.33333333333331167.0RepeatNote=ANK 15
HgeneTNKS2chr10:93617287chr10:112640990ENST00000371627+242790_1221031.33333333333331167.0RepeatNote=ANK 2
TgenePDCD4chr10:93617287chr10:112640990ENST00000280154112163_28414.333333333333334470.0DomainMI 1
TgenePDCD4chr10:93617287chr10:112640990ENST00000280154112326_44914.333333333333334470.0DomainMI 2
TgenePDCD4chr10:93617287chr10:112640990ENST00000393104213163_2843.3333333333333335459.0DomainMI 1
TgenePDCD4chr10:93617287chr10:112640990ENST00000393104213326_4493.3333333333333335459.0DomainMI 2
TgenePDCD4chr10:93617287chr10:112640990ENST00000280154112241_25014.333333333333334470.0MotifNuclear localization signal
TgenePDCD4chr10:93617287chr10:112640990ENST0000028015411258_6414.333333333333334470.0MotifNuclear localization signal
TgenePDCD4chr10:93617287chr10:112640990ENST0000028015411270_7614.333333333333334470.0MotifNote=Phosphodegron
TgenePDCD4chr10:93617287chr10:112640990ENST00000393104213241_2503.3333333333333335459.0MotifNuclear localization signal
TgenePDCD4chr10:93617287chr10:112640990ENST0000039310421358_643.3333333333333335459.0MotifNuclear localization signal
TgenePDCD4chr10:93617287chr10:112640990ENST0000039310421370_763.3333333333333335459.0MotifNote=Phosphodegron

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNKS2chr10:93617287chr10:112640990ENST00000371627+2427959_11641031.33333333333331167.0DomainPARP catalytic


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TNKS2
PDCD4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TNKS2-PDCD4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TNKS2-PDCD4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource