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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TNKS-ASAH1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TNKS-ASAH1
FusionPDB ID: 92746
FusionGDB2.0 ID: 92746
HgeneTgene
Gene symbol

TNKS

ASAH1

Gene ID

8658

427

Gene nametankyraseN-acylsphingosine amidohydrolase 1
SynonymsARTD5|PARP-5a|PARP5A|PARPL|TIN1|TINF1|TNKS1|pART5AC|ACDase|ASAH|PHP|PHP32|SMAPME
Cytomap

8p23.1

8p22

Type of geneprotein-codingprotein-coding
Descriptionpoly [ADP-ribose] polymerase tankyrase-1ADP-ribosyltransferase diphtheria toxin-like 5TANK1TNKS-1TRF1-interacting ankyrin-related ADP-ribose polymerase 1poly [ADP-ribose] polymerase 5Aprotein poly-ADP-ribosyltransferase tankyrase-1tankyrase Itankyacid ceramidaseN-acylethanolamine hydrolase ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 1acid CDaseacylsphingosine deacylaseputative 32 kDa heart protein
Modification date2020031320200313
UniProtAcc.

Q13510

Ensembl transtripts involved in fusion geneENST idsENST00000518027, ENST00000310430, 
ENST00000518281, ENST00000520408, 
ENST00000522110, 		ENST00000262097, 
ENST00000314146, ENST00000381733, 
ENST00000417108, ENST00000520781, 
ENST00000520051, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 8 X 8=83213 X 10 X 8=1040
# samples 1416
** MAII scorelog2(14/832*10)=-2.57115670119613
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1040*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TNKS [Title/Abstract] AND ASAH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TNKS(9473187)-ASAH1(17922040), # samples:3
Anticipated loss of major functional domain due to fusion event.TNKS-ASAH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TNKS-ASAH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TNKS-ASAH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TNKS-ASAH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTNKS

GO:0000209

protein polyubiquitination

19759537|21478859

HgeneTNKS

GO:0006471

protein ADP-ribosylation

9822378|15133513|21270334

HgeneTNKS

GO:0018105

peptidyl-serine phosphorylation

17026964

HgeneTNKS

GO:0018107

peptidyl-threonine phosphorylation

17026964

HgeneTNKS

GO:0032212

positive regulation of telomere maintenance via telomerase

12782650|18221737

HgeneTNKS

GO:0045944

positive regulation of transcription by RNA polymerase II

19245366

HgeneTNKS

GO:0051973

positive regulation of telomerase activity

12782650

HgeneTNKS

GO:0070212

protein poly-ADP-ribosylation

9822378|16076287|25043379

HgeneTNKS

GO:0070213

protein auto-ADP-ribosylation

9822378|15133513|19759537|21478859

HgeneTNKS

GO:1904355

positive regulation of telomere capping

21531765

HgeneTNKS

GO:1904743

negative regulation of telomeric DNA binding

9822378

TgeneASAH1

GO:0046512

sphingosine biosynthetic process

12815059

TgeneASAH1

GO:0046513

ceramide biosynthetic process

12764132|12815059

TgeneASAH1

GO:0046514

ceramide catabolic process

12815059


check buttonFusion gene breakpoints across TNKS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ASAH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A27N-01ATNKSchr8

9473187

+ASAH1chr8

17920739

-
ChimerDB4BRCATCGA-D8-A27N-01ATNKSchr8

9473187

-ASAH1chr8

17922040

-
ChimerDB4BRCATCGA-D8-A27N-01ATNKSchr8

9473187

+ASAH1chr8

17922040

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000520408TNKSchr89473187+ENST00000262097ASAH1chr817922040-29351020261825599
ENST00000520408TNKSchr89473187+ENST00000381733ASAH1chr817922040-29341020261825599
ENST00000310430TNKSchr89473187+ENST00000262097ASAH1chr817922040-29351020261825599
ENST00000310430TNKSchr89473187+ENST00000381733ASAH1chr817922040-29341020261825599
ENST00000518281TNKSchr89473187+ENST00000262097ASAH1chr817922040-26297144311519362
ENST00000518281TNKSchr89473187+ENST00000381733ASAH1chr817922040-26287144311519362
ENST00000520408TNKSchr89473187+ENST00000262097ASAH1chr817920739-28601020261750574
ENST00000520408TNKSchr89473187+ENST00000381733ASAH1chr817920739-28591020261750574
ENST00000520408TNKSchr89473187+ENST00000417108ASAH1chr817920739-28331020261750574
ENST00000520408TNKSchr89473187+ENST00000520781ASAH1chr817920739-28331020261750574
ENST00000520408TNKSchr89473187+ENST00000314146ASAH1chr817920739-20871020261750574
ENST00000310430TNKSchr89473187+ENST00000262097ASAH1chr817920739-28601020261750574
ENST00000310430TNKSchr89473187+ENST00000381733ASAH1chr817920739-28591020261750574
ENST00000310430TNKSchr89473187+ENST00000417108ASAH1chr817920739-28331020261750574
ENST00000310430TNKSchr89473187+ENST00000520781ASAH1chr817920739-28331020261750574
ENST00000310430TNKSchr89473187+ENST00000314146ASAH1chr817920739-20871020261750574
ENST00000518281TNKSchr89473187+ENST00000262097ASAH1chr817920739-25547144311444337
ENST00000518281TNKSchr89473187+ENST00000381733ASAH1chr817920739-25537144311444337
ENST00000518281TNKSchr89473187+ENST00000417108ASAH1chr817920739-25277144311444337
ENST00000518281TNKSchr89473187+ENST00000520781ASAH1chr817920739-25277144311444337
ENST00000518281TNKSchr89473187+ENST00000314146ASAH1chr817920739-17817144311444337

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000520408ENST00000262097TNKSchr89473187+ASAH1chr817922040-0.0004700420.99952996
ENST00000520408ENST00000381733TNKSchr89473187+ASAH1chr817922040-0.0004692730.9995308
ENST00000310430ENST00000262097TNKSchr89473187+ASAH1chr817922040-0.0004700420.99952996
ENST00000310430ENST00000381733TNKSchr89473187+ASAH1chr817922040-0.0004692730.9995308
ENST00000518281ENST00000262097TNKSchr89473187+ASAH1chr817922040-0.0002851320.9997148
ENST00000518281ENST00000381733TNKSchr89473187+ASAH1chr817922040-0.0002855630.99971443
ENST00000520408ENST00000262097TNKSchr89473187+ASAH1chr817920739-0.0004373170.9995627
ENST00000520408ENST00000381733TNKSchr89473187+ASAH1chr817920739-0.0004372730.9995627
ENST00000520408ENST00000417108TNKSchr89473187+ASAH1chr817920739-0.0003990480.99960095
ENST00000520408ENST00000520781TNKSchr89473187+ASAH1chr817920739-0.0003990480.99960095
ENST00000520408ENST00000314146TNKSchr89473187+ASAH1chr817920739-0.0024794750.9975205
ENST00000310430ENST00000262097TNKSchr89473187+ASAH1chr817920739-0.0004373170.9995627
ENST00000310430ENST00000381733TNKSchr89473187+ASAH1chr817920739-0.0004372730.9995627
ENST00000310430ENST00000417108TNKSchr89473187+ASAH1chr817920739-0.0003990480.99960095
ENST00000310430ENST00000520781TNKSchr89473187+ASAH1chr817920739-0.0003990480.99960095
ENST00000310430ENST00000314146TNKSchr89473187+ASAH1chr817920739-0.0024794750.9975205
ENST00000518281ENST00000262097TNKSchr89473187+ASAH1chr817920739-0.0002785470.99972147
ENST00000518281ENST00000381733TNKSchr89473187+ASAH1chr817920739-0.0002788260.9997211
ENST00000518281ENST00000417108TNKSchr89473187+ASAH1chr817920739-0.0002787420.9997212
ENST00000518281ENST00000520781TNKSchr89473187+ASAH1chr817920739-0.0002787420.9997212
ENST00000518281ENST00000314146TNKSchr89473187+ASAH1chr817920739-0.0006438180.9993562

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>92746_92746_1_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000310430_ASAH1_chr8_17920739_ENST00000262097_length(amino acids)=574AA_BP=331
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCC
STTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLC
QGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGHLIHGRNMDFGVFLGWNINNDTWVITEQ
LKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLT
KTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTK

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>92746_92746_2_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000310430_ASAH1_chr8_17920739_ENST00000314146_length(amino acids)=574AA_BP=331
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCC
STTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLC
QGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGHLIHGRNMDFGVFLGWNINNDTWVITEQ
LKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLT
KTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTK

--------------------------------------------------------------

>92746_92746_3_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000310430_ASAH1_chr8_17920739_ENST00000381733_length(amino acids)=574AA_BP=331
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCC
STTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLC
QGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGHLIHGRNMDFGVFLGWNINNDTWVITEQ
LKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLT
KTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTK

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>92746_92746_4_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000310430_ASAH1_chr8_17920739_ENST00000417108_length(amino acids)=574AA_BP=331
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCC
STTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLC
QGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGHLIHGRNMDFGVFLGWNINNDTWVITEQ
LKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLT
KTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTK

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>92746_92746_5_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000310430_ASAH1_chr8_17920739_ENST00000520781_length(amino acids)=574AA_BP=331
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCC
STTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLC
QGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGHLIHGRNMDFGVFLGWNINNDTWVITEQ
LKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLT
KTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTK

--------------------------------------------------------------

>92746_92746_6_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000310430_ASAH1_chr8_17922040_ENST00000262097_length(amino acids)=599AA_BP=329
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCC
STTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLC
QGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEIISFNIFYELFTICTSIVAEDKKGHLI
HGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDV
MWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTP

--------------------------------------------------------------

>92746_92746_7_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000310430_ASAH1_chr8_17922040_ENST00000381733_length(amino acids)=599AA_BP=329
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCC
STTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLC
QGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEIISFNIFYELFTICTSIVAEDKKGHLI
HGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDV
MWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTP

--------------------------------------------------------------

>92746_92746_8_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000518281_ASAH1_chr8_17920739_ENST00000262097_length(amino acids)=337AA_BP=94
MGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAK
AVLTGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILE
WILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPF

--------------------------------------------------------------

>92746_92746_9_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000518281_ASAH1_chr8_17920739_ENST00000314146_length(amino acids)=337AA_BP=94
MGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAK
AVLTGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILE
WILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPF

--------------------------------------------------------------

>92746_92746_10_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000518281_ASAH1_chr8_17920739_ENST00000381733_length(amino acids)=337AA_BP=94
MGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAK
AVLTGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILE
WILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPF

--------------------------------------------------------------

>92746_92746_11_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000518281_ASAH1_chr8_17920739_ENST00000417108_length(amino acids)=337AA_BP=94
MGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAK
AVLTGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILE
WILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPF

--------------------------------------------------------------

>92746_92746_12_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000518281_ASAH1_chr8_17920739_ENST00000520781_length(amino acids)=337AA_BP=94
MGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAK
AVLTGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILE
WILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPF

--------------------------------------------------------------

>92746_92746_13_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000518281_ASAH1_chr8_17922040_ENST00000262097_length(amino acids)=362AA_BP=92
MGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAK
AVLTGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTG
FKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLD
VYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCI

--------------------------------------------------------------

>92746_92746_14_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000518281_ASAH1_chr8_17922040_ENST00000381733_length(amino acids)=362AA_BP=92
MGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAK
AVLTGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTG
FKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLD
VYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCI

--------------------------------------------------------------

>92746_92746_15_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000520408_ASAH1_chr8_17920739_ENST00000262097_length(amino acids)=574AA_BP=331
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCC
STTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLC
QGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGHLIHGRNMDFGVFLGWNINNDTWVITEQ
LKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLT
KTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTK

--------------------------------------------------------------

>92746_92746_16_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000520408_ASAH1_chr8_17920739_ENST00000314146_length(amino acids)=574AA_BP=331
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCC
STTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLC
QGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGHLIHGRNMDFGVFLGWNINNDTWVITEQ
LKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLT
KTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTK

--------------------------------------------------------------

>92746_92746_17_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000520408_ASAH1_chr8_17920739_ENST00000381733_length(amino acids)=574AA_BP=331
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCC
STTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLC
QGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGHLIHGRNMDFGVFLGWNINNDTWVITEQ
LKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLT
KTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTK

--------------------------------------------------------------

>92746_92746_18_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000520408_ASAH1_chr8_17920739_ENST00000417108_length(amino acids)=574AA_BP=331
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCC
STTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLC
QGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGHLIHGRNMDFGVFLGWNINNDTWVITEQ
LKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLT
KTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTK

--------------------------------------------------------------

>92746_92746_19_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000520408_ASAH1_chr8_17920739_ENST00000520781_length(amino acids)=574AA_BP=331
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCC
STTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLC
QGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGHLIHGRNMDFGVFLGWNINNDTWVITEQ
LKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLT
KTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTK

--------------------------------------------------------------

>92746_92746_20_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000520408_ASAH1_chr8_17922040_ENST00000262097_length(amino acids)=599AA_BP=329
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCC
STTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLC
QGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEIISFNIFYELFTICTSIVAEDKKGHLI
HGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDV
MWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTP

--------------------------------------------------------------

>92746_92746_21_TNKS-ASAH1_TNKS_chr8_9473187_ENST00000520408_ASAH1_chr8_17922040_ENST00000381733_length(amino acids)=599AA_BP=329
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCC
STTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLC
QGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEIISFNIFYELFTICTSIVAEDKKGHLI
HGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDV
MWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTP

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:9473187/chr8:17922040)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ASAH1

Q13510

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (PubMed:10610716, PubMed:7744740, PubMed:15655246, PubMed:11451951). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:10610716). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (PubMed:7744740, PubMed:15655246). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:12764132, PubMed:12815059). For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used (PubMed:12764132). Has also an N-acylethanolamine hydrolase activity (PubMed:15655246). By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes (PubMed:17713573). Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (By similarity). By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis (PubMed:22261821). {ECO:0000250|UniProtKB:Q9WV54, ECO:0000269|PubMed:10610716, ECO:0000269|PubMed:11451951, ECO:0000269|PubMed:12764132, ECO:0000269|PubMed:12815059, ECO:0000269|PubMed:15655246, ECO:0000269|PubMed:17713573, ECO:0000269|PubMed:22261821, ECO:0000269|PubMed:7744740, ECO:0000303|PubMed:10610716}.; FUNCTION: [Isoform 2]: May directly regulate steroidogenesis by binding the nuclear receptor NR5A1 and negatively regulating its transcriptional activity. {ECO:0000305|PubMed:22927646}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327109_161331.33333333333331328.0Compositional biasSer-rich
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+32720_83331.33333333333331328.0Compositional biasPro-rich
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+3279_14331.33333333333331328.0Compositional biasPoly-His
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327109_161331.33333333333331328.0Compositional biasSer-rich
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+32720_83331.33333333333331328.0Compositional biasPro-rich
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+3279_14331.33333333333331328.0Compositional biasPoly-His
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327181_209331.33333333333331328.0RepeatANK 1
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327215_244331.33333333333331328.0RepeatANK 2
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327248_277331.33333333333331328.0RepeatANK 3
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327281_310331.33333333333331328.0RepeatANK 4
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327181_209331.33333333333331328.0RepeatANK 1
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327215_244331.33333333333331328.0RepeatANK 2
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327248_277331.33333333333331328.0RepeatANK 3
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327281_310331.33333333333331328.0RepeatANK 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+3271030_1089331.33333333333331328.0DomainSAM
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+3271112_1317331.33333333333331328.0DomainPARP catalytic
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+3271030_1089331.33333333333331328.0DomainSAM
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+3271112_1317331.33333333333331328.0DomainPARP catalytic
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327335_364331.33333333333331328.0RepeatANK 5
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327368_397331.33333333333331328.0RepeatANK 6
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327401_430331.33333333333331328.0RepeatANK 7
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327434_463331.33333333333331328.0RepeatANK 8
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327521_553331.33333333333331328.0RepeatANK 9
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327557_586331.33333333333331328.0RepeatANK 10
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327590_619331.33333333333331328.0RepeatANK 11
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327621_647331.33333333333331328.0RepeatANK 12
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327649_679331.33333333333331328.0RepeatANK 13
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327683_712331.33333333333331328.0RepeatANK 14
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327716_745331.33333333333331328.0RepeatANK 15
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327749_778331.33333333333331328.0RepeatANK 16
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327782_810331.33333333333331328.0RepeatANK 17
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327836_865331.33333333333331328.0RepeatANK 18
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327869_898331.33333333333331328.0RepeatANK 19
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327902_931331.33333333333331328.0RepeatANK 20
HgeneTNKSchr8:9473187chr8:17920739ENST00000310430+327935_964331.33333333333331328.0RepeatANK 21
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327335_364331.33333333333331328.0RepeatANK 5
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327368_397331.33333333333331328.0RepeatANK 6
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327401_430331.33333333333331328.0RepeatANK 7
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327434_463331.33333333333331328.0RepeatANK 8
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327521_553331.33333333333331328.0RepeatANK 9
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327557_586331.33333333333331328.0RepeatANK 10
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327590_619331.33333333333331328.0RepeatANK 11
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327621_647331.33333333333331328.0RepeatANK 12
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327649_679331.33333333333331328.0RepeatANK 13
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327683_712331.33333333333331328.0RepeatANK 14
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327716_745331.33333333333331328.0RepeatANK 15
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327749_778331.33333333333331328.0RepeatANK 16
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327782_810331.33333333333331328.0RepeatANK 17
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327836_865331.33333333333331328.0RepeatANK 18
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327869_898331.33333333333331328.0RepeatANK 19
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327902_931331.33333333333331328.0RepeatANK 20
HgeneTNKSchr8:9473187chr8:17922040ENST00000310430+327935_964331.33333333333331328.0RepeatANK 21


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TNKS
ASAH1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TNKS-ASAH1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TNKS-ASAH1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource