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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TNXB-VIM

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TNXB-VIM
FusionPDB ID: 92962
FusionGDB2.0 ID: 92962
HgeneTgene
Gene symbol

TNXB

VIM

Gene ID

7148

7431

Gene nametenascin XBvimentin
SynonymsEDS3|EDSCLL|EDSCLL1|HXBL|TENX|TN-X|TNX|TNXB1|TNXB2|TNXBS|VUR8|XB|XBS-
Cytomap

6p21.33-p21.32

10p13

Type of geneprotein-codingprotein-coding
Descriptiontenascin-Xgrowth-inhibiting protein 45hexabrachion-like proteintenascin XB1tenascin XB2vimentinepididymis secretory sperm binding protein
Modification date2020031320200327
UniProtAcc.

VMAC

Ensembl transtripts involved in fusion geneENST idsENST00000375244, ENST00000375247, 
ENST00000383159, ENST00000424718, 
ENST00000433037, ENST00000440248, 
ENST00000451343, ENST00000464376, 
ENST00000465958, ENST00000469250, 
ENST00000471059, ENST00000475986, 
ENST00000479795, ENST00000489006, 
ENST00000546684, ENST00000548628, 
ENST00000548649, ENST00000549232, 
ENST00000549652, ENST00000550212, 
ENST00000550539, ENST00000551201, 
ENST00000551808, ENST00000552149, 
ENST00000552665, ENST00000553092, 
ENST00000485947, ENST00000224237, 
ENST00000544301, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 4 X 4=6442 X 25 X 11=11550
# samples 441
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(41/11550*10)=-4.81612513168534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TNXB [Title/Abstract] AND VIM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TNXB(32016140)-VIM(17278293), # samples:1
Anticipated loss of major functional domain due to fusion event.TNXB-VIM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TNXB-VIM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TNXB-VIM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TNXB-VIM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TNXB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VIM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AB2T-01ATNXBchr6

32016140

-VIMchr10

17278293

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375244TNXBchr632016140-ENST00000544301VIMchr1017278293+1068910247202103743390
ENST00000375244TNXBchr632016140-ENST00000224237VIMchr1017278293+1069710247202103743390
ENST00000375247TNXBchr632016140-ENST00000544301VIMchr1017278293+1068310241202103683388
ENST00000375247TNXBchr632016140-ENST00000224237VIMchr1017278293+1069110241202103683388

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375244ENST00000544301TNXBchr632016140-VIMchr1017278293+0.0008060980.99919397
ENST00000375244ENST00000224237TNXBchr632016140-VIMchr1017278293+0.0008050.99919504
ENST00000375247ENST00000544301TNXBchr632016140-VIMchr1017278293+0.0006477240.9993523
ENST00000375247ENST00000224237TNXBchr632016140-VIMchr1017278293+0.0006467940.99935323

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>92962_92962_1_TNXB-VIM_TNXB_chr6_32016140_ENST00000375244_VIM_chr10_17278293_ENST00000224237_length(amino acids)=3390AA_BP=3327
MMPAQYALTSSLVLLVLLSTARAGPFSSRSNVTLPAPRPPPQPGGHTVGAGVGSPSSQLYEHTVEGGEKQVVFTHRINLPPSTGCGCPPG
TEPPVLASEVQALRVRLEILEELVKGLKEQCTGGCCPASAQAGTGQTDVRTLCSLHGVFDLSRCTCSCEPGWGGPTCSDPTDAEIPPSSP
PSASGSCPDDCNDQGRCVRGRCVCFPGYTGPSCGWPSCPGDCQGRGRCVQGVCVCRAGFSGPDCSQRSCPRGCSQRGRCEGGRCVCDPGY
TGDDCGMRSCPRGCSQRGRCENGRCVCNPGYTGEDCGVRSCPRGCSQRGRCKDGRCVCDPGYTGEDCGTRSCPWDCGEGGRCVDGRCVCW
PGYTGEDCSTRTCPRDCRGRGRCEDGECICDTGYSGDDCGVRSCPGDCNQRGRCEDGRCVCWPGYTGTDCGSRACPRDCRGRGRCENGVC
VCNAGYSGEDCGVRSCPGDCRGRGRCESGRCMCWPGYTGRDCGTRACPGDCRGRGRCVDGRCVCNPGFTGEDCGSRRCPGDCRGHGLCED
GVCVCDAGYSGEDCSTRSCPGGCRGRGQCLDGRCVCEDGYSGEDCGVRQCPNDCSQHGVCQDGVCICWEGYVSEDCSIRTCPSNCHGRGR
CEEGRCLCDPGYTGPTCATRMCPADCRGRGRCVQGVCLCHVGYGGEDCGQEEPPASACPGGCGPRELCRAGQCVCVEGFRGPDCAIQTCP
GDCRGRGECHDGSCVCKDGYAGEDCGEEVPTIEGMRMHLLEETTVRTEWTPAPGPVDAYEIQFIPTTEGASPPFTARVPSSASAYDQRGL
APGQEYQVTVRALRGTSWGLPASKTITTMIDGPQDLRVVAVTPTTLELGWLRPQAEVDRFVVSYVSAGNQRVRLEVPPEADGTLLTDLMP
GVEYVVTVTAERGRAVSYPASVRANTGSSPLGLLGTTDEPPPSGPSTTQGAQAPLLQQRPQELGELRVLGRDETGRLRVVWTAQPDTFAY
FQLRMRVPEGPGAHEEVLPGDVRQALVPPPPPGTPYELSLHGVPPGGKPSDPIIYQGIMDKDEEKPGKSSGPPRLGELTVTDRTSDSLLL
RWTVPEGEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVGKKRHGPLVAEAKILPQSDPSPGTPPHLGNLWVTDP
TPDSLHLSWTVPEGQFDTFMVQYRDRDGRPQVVPVEGPERSFVVSSLDPDHKYRFTLFGIANKKRYGPLTADGTTAPERKEEPPRPEFLE
QPLLGELTVTGVTPDSLRLSWTVAQGPFDSFMVQYKDAQGQPQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGRQRVGPESVVAKTAPQ
EDVDETPSPTELGTEAPESPEEPLLGELTVTGSSPDSLSLFWTVPQGSFDSFTVQYKDRDGRPRAVRVGGKESEVTVGGLEPGHKYKMHL
YGLHEGQRVGPVSAVGVTAPQQEETPPATESPLEPRLGELTVTDVTPNSVGLSWTVPEGQFDSFIVQYKDKDGQPQVVPVAADQREVTVY
NLEPERKYKMNMYGLHDGQRMGPLSVVIVTAPLPPAPATEASKPPLEPRLGELTVTDITPDSVGLSWTVPEGEFDSFVVQYKDRDGQPQV
VPVAADQREVTIPDLEPSRKYKFLLFGIQDGKRRSPVSVEAKTVARGDASPGAPPRLGELWVTDPTPDSLRLSWTVPEGQFDSFVVQFKD
KDGPQVVPVEGHERSVTVTPLDAGRKYRFLLYGLLGKKRHGPLTADGTTEARSAMDDTGTKRPPKPRLGEELQVTTVTQNSVGLSWTVPE
GQFDSFVVQYKDRDGQPQVVPVEGSLREVSVPGLDPAHRYKLLLYGLHHGKRVGPISAVAITAGREETETETTAPTPPAPEPHLGELTVE
EATSHTLHLSWMVTEGEFDSFEIQYTDRDGQLQMVRIGGDRNDITLSGLESDHRYLVTLYGFSDGKHVGPVHVEALTVPEEEKPSEPPTA
TPEPPIKPRLGELTVTDATPDSLSLSWTVPEGQFDHFLVQYRNGDGQPKAVRVPGHEEGVTISGLEPDHKYKMNLYGFHGGQRMGPVSVV
GVTAAEEETPSPTEPSMEAPEPAEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYK
MHLYGLHEGRRVGPVSAVGVTAPEEESPDAPLAKLRLGQMTVRDITSDSLSLSWTVPEGQFDHFLVQFKNGDGQPKAVRVPGHEDGVTIS
GLEPDHKYKMNLYGFHGGQRVGPVSAVGLTAPGKDEEMAPASTEPPTPEPPIKPRLEELTVTDATPDSLSLSWTVPEGQFDHFLVQYKNG
DGQPKATRVPGHEDRVTISGLEPDNKYKMNLYGFHGGQRVGPVSAIGVTAAEEETPSPTEPSMEAPEPPEEPLLGELTVTGSSPDSLSLS
WTVPQGRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSTVGVTAPQEDVDETPSPTEPGTEAPGPP
EEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQAVRVGGQESKVTVRGLEPGRKYKMHLYGLHEGRRLGPVSAVGVTED
EAETTQAVPTMTPEPPIKPRLGELTMTDATPDSLSLSWTVPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFH
GGQRVGPISVIGVTAAEEETPSPTELSTEAPEPPEEPLLGELTVTGSSPDSLSLSWTIPQGHFDSFTVQYKDRDGRPQVMRVRGEESEVT
VGGLEPGRKYKMHLYGLHEGRRVGPVSTVGVTAPEDEAETTQAVPTTTPEPPNKPRLGELTVTDATPDSLSLSWMVPEGQFDHFLVQYRN
GDGQPKVVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPISVIGVTAAEEETPAPTEPSTEAPEPPEEPLLGELTVTGSSPDSLSL
SWTIPQGRFDSFTVQYKDRDGRPQVVRVRGEESEVTVGGLEPGCKYKMHLYGLHEGQRVGPVSAVGVTAPKDEAETTQAVPTMTPEPPIK
PRLGELTVTDATPDSLSLSWMVPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPVSAIGVTEEET
PSPTEPSTEAPEAPEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGQPQVVRVRGEESEVTVGGLEPGRKYKMHLYGLHEG
QRVGPVSTVGITAPLPTPLPVEPRLGELAVAAVTSDSVGLSWTVAQGPFDSFLVQYRDAQGQPQAVPVSGDLRAVAVSGLDPARKYKFLL

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>92962_92962_2_TNXB-VIM_TNXB_chr6_32016140_ENST00000375244_VIM_chr10_17278293_ENST00000544301_length(amino acids)=3390AA_BP=3327
MMPAQYALTSSLVLLVLLSTARAGPFSSRSNVTLPAPRPPPQPGGHTVGAGVGSPSSQLYEHTVEGGEKQVVFTHRINLPPSTGCGCPPG
TEPPVLASEVQALRVRLEILEELVKGLKEQCTGGCCPASAQAGTGQTDVRTLCSLHGVFDLSRCTCSCEPGWGGPTCSDPTDAEIPPSSP
PSASGSCPDDCNDQGRCVRGRCVCFPGYTGPSCGWPSCPGDCQGRGRCVQGVCVCRAGFSGPDCSQRSCPRGCSQRGRCEGGRCVCDPGY
TGDDCGMRSCPRGCSQRGRCENGRCVCNPGYTGEDCGVRSCPRGCSQRGRCKDGRCVCDPGYTGEDCGTRSCPWDCGEGGRCVDGRCVCW
PGYTGEDCSTRTCPRDCRGRGRCEDGECICDTGYSGDDCGVRSCPGDCNQRGRCEDGRCVCWPGYTGTDCGSRACPRDCRGRGRCENGVC
VCNAGYSGEDCGVRSCPGDCRGRGRCESGRCMCWPGYTGRDCGTRACPGDCRGRGRCVDGRCVCNPGFTGEDCGSRRCPGDCRGHGLCED
GVCVCDAGYSGEDCSTRSCPGGCRGRGQCLDGRCVCEDGYSGEDCGVRQCPNDCSQHGVCQDGVCICWEGYVSEDCSIRTCPSNCHGRGR
CEEGRCLCDPGYTGPTCATRMCPADCRGRGRCVQGVCLCHVGYGGEDCGQEEPPASACPGGCGPRELCRAGQCVCVEGFRGPDCAIQTCP
GDCRGRGECHDGSCVCKDGYAGEDCGEEVPTIEGMRMHLLEETTVRTEWTPAPGPVDAYEIQFIPTTEGASPPFTARVPSSASAYDQRGL
APGQEYQVTVRALRGTSWGLPASKTITTMIDGPQDLRVVAVTPTTLELGWLRPQAEVDRFVVSYVSAGNQRVRLEVPPEADGTLLTDLMP
GVEYVVTVTAERGRAVSYPASVRANTGSSPLGLLGTTDEPPPSGPSTTQGAQAPLLQQRPQELGELRVLGRDETGRLRVVWTAQPDTFAY
FQLRMRVPEGPGAHEEVLPGDVRQALVPPPPPGTPYELSLHGVPPGGKPSDPIIYQGIMDKDEEKPGKSSGPPRLGELTVTDRTSDSLLL
RWTVPEGEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVGKKRHGPLVAEAKILPQSDPSPGTPPHLGNLWVTDP
TPDSLHLSWTVPEGQFDTFMVQYRDRDGRPQVVPVEGPERSFVVSSLDPDHKYRFTLFGIANKKRYGPLTADGTTAPERKEEPPRPEFLE
QPLLGELTVTGVTPDSLRLSWTVAQGPFDSFMVQYKDAQGQPQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGRQRVGPESVVAKTAPQ
EDVDETPSPTELGTEAPESPEEPLLGELTVTGSSPDSLSLFWTVPQGSFDSFTVQYKDRDGRPRAVRVGGKESEVTVGGLEPGHKYKMHL
YGLHEGQRVGPVSAVGVTAPQQEETPPATESPLEPRLGELTVTDVTPNSVGLSWTVPEGQFDSFIVQYKDKDGQPQVVPVAADQREVTVY
NLEPERKYKMNMYGLHDGQRMGPLSVVIVTAPLPPAPATEASKPPLEPRLGELTVTDITPDSVGLSWTVPEGEFDSFVVQYKDRDGQPQV
VPVAADQREVTIPDLEPSRKYKFLLFGIQDGKRRSPVSVEAKTVARGDASPGAPPRLGELWVTDPTPDSLRLSWTVPEGQFDSFVVQFKD
KDGPQVVPVEGHERSVTVTPLDAGRKYRFLLYGLLGKKRHGPLTADGTTEARSAMDDTGTKRPPKPRLGEELQVTTVTQNSVGLSWTVPE
GQFDSFVVQYKDRDGQPQVVPVEGSLREVSVPGLDPAHRYKLLLYGLHHGKRVGPISAVAITAGREETETETTAPTPPAPEPHLGELTVE
EATSHTLHLSWMVTEGEFDSFEIQYTDRDGQLQMVRIGGDRNDITLSGLESDHRYLVTLYGFSDGKHVGPVHVEALTVPEEEKPSEPPTA
TPEPPIKPRLGELTVTDATPDSLSLSWTVPEGQFDHFLVQYRNGDGQPKAVRVPGHEEGVTISGLEPDHKYKMNLYGFHGGQRMGPVSVV
GVTAAEEETPSPTEPSMEAPEPAEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYK
MHLYGLHEGRRVGPVSAVGVTAPEEESPDAPLAKLRLGQMTVRDITSDSLSLSWTVPEGQFDHFLVQFKNGDGQPKAVRVPGHEDGVTIS
GLEPDHKYKMNLYGFHGGQRVGPVSAVGLTAPGKDEEMAPASTEPPTPEPPIKPRLEELTVTDATPDSLSLSWTVPEGQFDHFLVQYKNG
DGQPKATRVPGHEDRVTISGLEPDNKYKMNLYGFHGGQRVGPVSAIGVTAAEEETPSPTEPSMEAPEPPEEPLLGELTVTGSSPDSLSLS
WTVPQGRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSTVGVTAPQEDVDETPSPTEPGTEAPGPP
EEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQAVRVGGQESKVTVRGLEPGRKYKMHLYGLHEGRRLGPVSAVGVTED
EAETTQAVPTMTPEPPIKPRLGELTMTDATPDSLSLSWTVPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFH
GGQRVGPISVIGVTAAEEETPSPTELSTEAPEPPEEPLLGELTVTGSSPDSLSLSWTIPQGHFDSFTVQYKDRDGRPQVMRVRGEESEVT
VGGLEPGRKYKMHLYGLHEGRRVGPVSTVGVTAPEDEAETTQAVPTTTPEPPNKPRLGELTVTDATPDSLSLSWMVPEGQFDHFLVQYRN
GDGQPKVVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPISVIGVTAAEEETPAPTEPSTEAPEPPEEPLLGELTVTGSSPDSLSL
SWTIPQGRFDSFTVQYKDRDGRPQVVRVRGEESEVTVGGLEPGCKYKMHLYGLHEGQRVGPVSAVGVTAPKDEAETTQAVPTMTPEPPIK
PRLGELTVTDATPDSLSLSWMVPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPVSAIGVTEEET
PSPTEPSTEAPEAPEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGQPQVVRVRGEESEVTVGGLEPGRKYKMHLYGLHEG
QRVGPVSTVGITAPLPTPLPVEPRLGELAVAAVTSDSVGLSWTVAQGPFDSFLVQYRDAQGQPQAVPVSGDLRAVAVSGLDPARKYKFLL

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>92962_92962_3_TNXB-VIM_TNXB_chr6_32016140_ENST00000375247_VIM_chr10_17278293_ENST00000224237_length(amino acids)=3388AA_BP=3325
MMPAQYALTSSLVLLVLLSTARAGPFSSRSNVTLPAPRPPPQPGGHTVGAGVGSPSSQLYEHTVEGGEKQVVFTHRINLPPSTGCGCPPG
TEPPVLASEVQALRVRLEILEELVKGLKEQCTGGCCPASAQAGTGQTDVRTLCSLHGVFDLSRCTCSCEPGWGGPTCSDPTDAEIPPSSP
PSASGSCPDDCNDQGRCVRGRCVCFPGYTGPSCGWPSCPGDCQGRGRCVQGVCVCRAGFSGPDCSQRSCPRGCSQRGRCEGGRCVCDPGY
TGDDCGMRSCPRGCSQRGRCENGRCVCNPGYTGEDCGVRSCPRGCSQRGRCKDGRCVCDPGYTGEDCGTRSCPWDCGEGGRCVDGRCVCW
PGYTGEDCSTRTCPRDCRGRGRCEDGECICDTGYSGDDCGVRSCPGDCNQRGRCEDGRCVCWPGYTGTDCGSRACPRDCRGRGRCENGVC
VCNAGYSGEDCGVRSCPGDCRGRGRCESGRCMCWPGYTGRDCGTRACPGDCRGRGRCVDGRCVCNPGFTGEDCGSRRCPGDCRGHGLCED
GVCVCDAGYSGEDCSTRSCPGGCRGRGQCLDGRCVCEDGYSGEDCGVRQCPNDCSQHGVCQDGVCICWEGYVSEDCSIRTCPSNCHGRGR
CEEGRCLCDPGYTGPTCATRMCPADCRGRGRCVQGVCLCHVGYGGEDCGQEEPPASACPGGCGPRELCRAGQCVCVEGFRGPDCAIQTCP
GDCRGRGECHDGSCVCKDGYAGEDCGEEVPTIEGMRMHLLEETTVRTEWTPAPGPVDAYEIQFIPTTEGASPPFTARVPSSASAYDQRGL
APGQEYQVTVRALRGTSWGLPASKTITTMIDGPQDLRVVAVTPTTLELGWLRPQAEVDRFVVSYVSAGNQRVRLEVPPEADGTLLTDLMP
GVEYVVTVTAERGRAVSYPASVRANTGSSPLGLLGTTDEPPPSGPSTTQGAQAPLLQQRPQELGELRVLGRDETGRLRVVWTAQPDTFAY
FQLRMRVPEGPGAHEEVLPGDVRQALVPPPPPGTPYELSLHGVPPGGKPSDPIIYQGIMDKDEEKPGKSSGPPRLGELTVTDRTSDSLLL
RWTVPEGEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVGKKRHGPLVAEAKILPQSDPSPGTPPHLGNLWVTDP
TPDSLHLSWTVPEGQFDTFMVQYRDRDGRPQVVPVEGPERSFVVSSLDPDHKYRFTLFGIANKKRYGPLTADGTTAPERKEEPPRPEFLE
QPLLGELTVTGVTPDSLRLSWTVAQGPFDSFMVQYKDAQGQPQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGRQRVGPESVVAKTAPQ
EDVDETPSPTELGTEAPESPEEPLLGELTVTGSSPDSLSLFWTVPQGSFDSFTVQYKDRDGRPRAVRVGGKESEVTVGGLEPGHKYKMHL
YGLHEGQRVGPVSAVGVTAPQQEETPPATESPLEPRLGELTVTDVTPNSVGLSWTVPEGQFDSFIVQYKDKDGQPQVVPVAADQREVTVY
NLEPERKYKMNMYGLHDGQRMGPLSVVIVTAPLPPAPATEASKPPLEPRLGELTVTDITPDSVGLSWTVPEGEFDSFVVQYKDRDGQPQV
VPVAADQREVTIPDLEPSRKYKFLLFGIQDGKRRSPVSVEAKTVARGDASPGAPPRLGELWVTDPTPDSLRLSWTVPEGQFDSFVVQFKD
KDGPQVVPVEGHERSVTVTPLDAGRKYRFLLYGLLGKKRHGPLTADGTTEARSAMDDTGTKRPPKPRLGEELQVTTVTQNSVGLSWTVPE
GQFDSFVVQYKDRDGQPQVVPVEGSLREVSVPGLDPAHRYKLLLYGLHHGKRVGPISAVAITAGREETETETTAPTPPAPEPHLGELTVE
EATSHTLHLSWMVTEGEFDSFEIQYTDRDGQLQMVRIGGDRNDITLSGLESDHRYLVTLYGFSDGKHVGPVHVEALTVPEEEKPSEPPTA
TPEPPIKPRLGELTVTDATPDSLSLSWTVPEGQFDHFLVQYRNGDGQPKAVRVPGHEEGVTISGLEPDHKYKMNLYGFHGGQRMGPVSVV
GVTAAEEETPSPTEPSMEAPEPAEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYK
MHLYGLHEGRRVGPVSAVGVTAPEEESPDAPLAKLRLGQMTVRDITSDSLSLSWTVPEGQFDHFLVQFKNGDGQPKAVRVPGHEDGVTIS
GLEPDHKYKMNLYGFHGGQRVGPVSAVGLTAPGKDEEMAPASTEPPTPEPPIKPRLEELTVTDATPDSLSLSWTVPEGQFDHFLVQYKNG
DGQPKATRVPGHEDRVTISGLEPDNKYKMNLYGFHGGQRVGPVSAIGVTAAEEETPSPTEPSMEAPEPPEEPLLGELTVTGSSPDSLSLS
WTVPQGRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSTVGVTAPQEDVDETPSPTEPGTEAPGPP
EEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQAVRVGGQESKVTVRGLEPGRKYKMHLYGLHEGRRLGPVSAVGVTED
EAETTQAVPTMTPEPPIKPRLGELTMTDATPDSLSLSWTVPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFH
GGQRVGPISVIGVTAAEEETPSPTELSTEAPEPPEEPLLGELTVTGSSPDSLSLSWTIPQGHFDSFTVQYKDRDGRPQVMRVRGEESEVT
VGGLEPGRKYKMHLYGLHEGRRVGPVSTVGVTEDEAETTQAVPTTTPEPPNKPRLGELTVTDATPDSLSLSWMVPEGQFDHFLVQYRNGD
GQPKVVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPISVIGVTAAEEETPAPTEPSTEAPEPPEEPLLGELTVTGSSPDSLSLSW
TIPQGRFDSFTVQYKDRDGRPQVVRVRGEESEVTVGGLEPGCKYKMHLYGLHEGQRVGPVSAVGVTAPKDEAETTQAVPTMTPEPPIKPR
LGELTVTDATPDSLSLSWMVPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPVSAIGVTEEETPS
PTEPSTEAPEAPEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGQPQVVRVRGEESEVTVGGLEPGRKYKMHLYGLHEGQR
VGPVSTVGITAPLPTPLPVEPRLGELAVAAVTSDSVGLSWTVAQGPFDSFLVQYRDAQGQPQAVPVSGDLRAVAVSGLDPARKYKFLLFG

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>92962_92962_4_TNXB-VIM_TNXB_chr6_32016140_ENST00000375247_VIM_chr10_17278293_ENST00000544301_length(amino acids)=3388AA_BP=3325
MMPAQYALTSSLVLLVLLSTARAGPFSSRSNVTLPAPRPPPQPGGHTVGAGVGSPSSQLYEHTVEGGEKQVVFTHRINLPPSTGCGCPPG
TEPPVLASEVQALRVRLEILEELVKGLKEQCTGGCCPASAQAGTGQTDVRTLCSLHGVFDLSRCTCSCEPGWGGPTCSDPTDAEIPPSSP
PSASGSCPDDCNDQGRCVRGRCVCFPGYTGPSCGWPSCPGDCQGRGRCVQGVCVCRAGFSGPDCSQRSCPRGCSQRGRCEGGRCVCDPGY
TGDDCGMRSCPRGCSQRGRCENGRCVCNPGYTGEDCGVRSCPRGCSQRGRCKDGRCVCDPGYTGEDCGTRSCPWDCGEGGRCVDGRCVCW
PGYTGEDCSTRTCPRDCRGRGRCEDGECICDTGYSGDDCGVRSCPGDCNQRGRCEDGRCVCWPGYTGTDCGSRACPRDCRGRGRCENGVC
VCNAGYSGEDCGVRSCPGDCRGRGRCESGRCMCWPGYTGRDCGTRACPGDCRGRGRCVDGRCVCNPGFTGEDCGSRRCPGDCRGHGLCED
GVCVCDAGYSGEDCSTRSCPGGCRGRGQCLDGRCVCEDGYSGEDCGVRQCPNDCSQHGVCQDGVCICWEGYVSEDCSIRTCPSNCHGRGR
CEEGRCLCDPGYTGPTCATRMCPADCRGRGRCVQGVCLCHVGYGGEDCGQEEPPASACPGGCGPRELCRAGQCVCVEGFRGPDCAIQTCP
GDCRGRGECHDGSCVCKDGYAGEDCGEEVPTIEGMRMHLLEETTVRTEWTPAPGPVDAYEIQFIPTTEGASPPFTARVPSSASAYDQRGL
APGQEYQVTVRALRGTSWGLPASKTITTMIDGPQDLRVVAVTPTTLELGWLRPQAEVDRFVVSYVSAGNQRVRLEVPPEADGTLLTDLMP
GVEYVVTVTAERGRAVSYPASVRANTGSSPLGLLGTTDEPPPSGPSTTQGAQAPLLQQRPQELGELRVLGRDETGRLRVVWTAQPDTFAY
FQLRMRVPEGPGAHEEVLPGDVRQALVPPPPPGTPYELSLHGVPPGGKPSDPIIYQGIMDKDEEKPGKSSGPPRLGELTVTDRTSDSLLL
RWTVPEGEFDSFVIQYKDRDGQPQVVPVEGPQRSAVITSLDPGRKYKFVLYGFVGKKRHGPLVAEAKILPQSDPSPGTPPHLGNLWVTDP
TPDSLHLSWTVPEGQFDTFMVQYRDRDGRPQVVPVEGPERSFVVSSLDPDHKYRFTLFGIANKKRYGPLTADGTTAPERKEEPPRPEFLE
QPLLGELTVTGVTPDSLRLSWTVAQGPFDSFMVQYKDAQGQPQAVPVAGDENEVTVPGLDPDRKYKMNLYGLRGRQRVGPESVVAKTAPQ
EDVDETPSPTELGTEAPESPEEPLLGELTVTGSSPDSLSLFWTVPQGSFDSFTVQYKDRDGRPRAVRVGGKESEVTVGGLEPGHKYKMHL
YGLHEGQRVGPVSAVGVTAPQQEETPPATESPLEPRLGELTVTDVTPNSVGLSWTVPEGQFDSFIVQYKDKDGQPQVVPVAADQREVTVY
NLEPERKYKMNMYGLHDGQRMGPLSVVIVTAPLPPAPATEASKPPLEPRLGELTVTDITPDSVGLSWTVPEGEFDSFVVQYKDRDGQPQV
VPVAADQREVTIPDLEPSRKYKFLLFGIQDGKRRSPVSVEAKTVARGDASPGAPPRLGELWVTDPTPDSLRLSWTVPEGQFDSFVVQFKD
KDGPQVVPVEGHERSVTVTPLDAGRKYRFLLYGLLGKKRHGPLTADGTTEARSAMDDTGTKRPPKPRLGEELQVTTVTQNSVGLSWTVPE
GQFDSFVVQYKDRDGQPQVVPVEGSLREVSVPGLDPAHRYKLLLYGLHHGKRVGPISAVAITAGREETETETTAPTPPAPEPHLGELTVE
EATSHTLHLSWMVTEGEFDSFEIQYTDRDGQLQMVRIGGDRNDITLSGLESDHRYLVTLYGFSDGKHVGPVHVEALTVPEEEKPSEPPTA
TPEPPIKPRLGELTVTDATPDSLSLSWTVPEGQFDHFLVQYRNGDGQPKAVRVPGHEEGVTISGLEPDHKYKMNLYGFHGGQRMGPVSVV
GVTAAEEETPSPTEPSMEAPEPAEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYK
MHLYGLHEGRRVGPVSAVGVTAPEEESPDAPLAKLRLGQMTVRDITSDSLSLSWTVPEGQFDHFLVQFKNGDGQPKAVRVPGHEDGVTIS
GLEPDHKYKMNLYGFHGGQRVGPVSAVGLTAPGKDEEMAPASTEPPTPEPPIKPRLEELTVTDATPDSLSLSWTVPEGQFDHFLVQYKNG
DGQPKATRVPGHEDRVTISGLEPDNKYKMNLYGFHGGQRVGPVSAIGVTAAEEETPSPTEPSMEAPEPPEEPLLGELTVTGSSPDSLSLS
WTVPQGRFDSFTVQYKDRDGRPQVVRVGGEESEVTVGGLEPGRKYKMHLYGLHEGRRVGPVSTVGVTAPQEDVDETPSPTEPGTEAPGPP
EEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGRPQAVRVGGQESKVTVRGLEPGRKYKMHLYGLHEGRRLGPVSAVGVTED
EAETTQAVPTMTPEPPIKPRLGELTMTDATPDSLSLSWTVPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFH
GGQRVGPISVIGVTAAEEETPSPTELSTEAPEPPEEPLLGELTVTGSSPDSLSLSWTIPQGHFDSFTVQYKDRDGRPQVMRVRGEESEVT
VGGLEPGRKYKMHLYGLHEGRRVGPVSTVGVTEDEAETTQAVPTTTPEPPNKPRLGELTVTDATPDSLSLSWMVPEGQFDHFLVQYRNGD
GQPKVVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPISVIGVTAAEEETPAPTEPSTEAPEPPEEPLLGELTVTGSSPDSLSLSW
TIPQGRFDSFTVQYKDRDGRPQVVRVRGEESEVTVGGLEPGCKYKMHLYGLHEGQRVGPVSAVGVTAPKDEAETTQAVPTMTPEPPIKPR
LGELTVTDATPDSLSLSWMVPEGQFDHFLVQYRNGDGQPKAVRVPGHEDGVTISGLEPDHKYKMNLYGFHGGQRVGPVSAIGVTEEETPS
PTEPSTEAPEAPEEPLLGELTVTGSSPDSLSLSWTVPQGRFDSFTVQYKDRDGQPQVVRVRGEESEVTVGGLEPGRKYKMHLYGLHEGQR
VGPVSTVGITAPLPTPLPVEPRLGELAVAAVTSDSVGLSWTVAQGPFDSFLVQYRDAQGQPQAVPVSGDLRAVAVSGLDPARKYKFLLFG

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:32016140/chr10:17278293)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.VIM

VMAC

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.169

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29441064_11533346.33333333333354243.0DomainFibronectin type-III 2
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29441161_12493346.33333333333354243.0DomainFibronectin type-III 3
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29441263_13523346.33333333333354243.0DomainFibronectin type-III 4
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29441374_14683346.33333333333354243.0DomainFibronectin type-III 5
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29441476_15723346.33333333333354243.0DomainFibronectin type-III 6
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944156_1683346.33333333333354243.0DomainEGF-like 1%3B incomplete
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29441574_16693346.33333333333354243.0DomainFibronectin type-III 7
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29441674_17643346.33333333333354243.0DomainFibronectin type-III 8
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29441778_18683346.33333333333354243.0DomainFibronectin type-III 9
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944183_2133346.33333333333354243.0DomainEGF-like 2
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29441883_19713346.33333333333354243.0DomainFibronectin type-III 10
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29441989_20893346.33333333333354243.0DomainFibronectin type-III 11
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29442097_21853346.33333333333354243.0DomainFibronectin type-III 12
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944214_2443346.33333333333354243.0DomainEGF-like 3
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29442196_22963346.33333333333354243.0DomainFibronectin type-III 13
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29442305_23983346.33333333333354243.0DomainFibronectin type-III 14
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29442408_25023346.33333333333354243.0DomainFibronectin type-III 15
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944245_2753346.33333333333354243.0DomainEGF-like 4
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29442519_26173346.33333333333354243.0DomainFibronectin type-III 16
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29442625_27233346.33333333333354243.0DomainFibronectin type-III 17
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29442733_28403346.33333333333354243.0DomainFibronectin type-III 18
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944276_3063346.33333333333354243.0DomainEGF-like 5
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29442841_29393346.33333333333354243.0DomainFibronectin type-III 19
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29442949_30423346.33333333333354243.0DomainFibronectin type-III 20
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29443062_31533346.33333333333354243.0DomainFibronectin type-III 21
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944307_3373346.33333333333354243.0DomainEGF-like 6
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29443168_32603346.33333333333354243.0DomainFibronectin type-III 22
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944338_3683346.33333333333354243.0DomainEGF-like 7
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944369_3993346.33333333333354243.0DomainEGF-like 8
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944400_4303346.33333333333354243.0DomainEGF-like 9
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944431_4613346.33333333333354243.0DomainEGF-like 10
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944462_4923346.33333333333354243.0DomainEGF-like 11
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944493_5233346.33333333333354243.0DomainEGF-like 12
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944524_5543346.33333333333354243.0DomainEGF-like 13
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944555_5853346.33333333333354243.0DomainEGF-like 14
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944586_6163346.33333333333354243.0DomainEGF-like 15
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944617_6473346.33333333333354243.0DomainEGF-like 16
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944648_6793346.33333333333354243.0DomainEGF-like 17
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944684_7143346.33333333333354243.0DomainEGF-like 18
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944715_7463346.33333333333354243.0DomainEGF-like 19
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-2944959_10513346.33333333333354243.0DomainFibronectin type-III 1
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29441666_16683346.33333333333354243.0MotifCell attachment site

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29443264_33553346.33333333333354243.0DomainFibronectin type-III 23
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29443357_34463346.33333333333354243.0DomainFibronectin type-III 24
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29443451_35443346.33333333333354243.0DomainFibronectin type-III 25
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29443553_36473346.33333333333354243.0DomainFibronectin type-III 26
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29443657_37543346.33333333333354243.0DomainFibronectin type-III 27
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29443758_38473346.33333333333354243.0DomainFibronectin type-III 28
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29443848_39343346.33333333333354243.0DomainFibronectin type-III 29
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29443935_40253346.33333333333354243.0DomainFibronectin type-III 30
HgeneTNXBchr6:32016140chr10:17278293ENST00000375247-29444021_42363346.33333333333354243.0DomainFibrinogen C-terminal
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1131064_11530674.0DomainFibronectin type-III 2
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1131161_12490674.0DomainFibronectin type-III 3
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1131263_13520674.0DomainFibronectin type-III 4
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1131374_14680674.0DomainFibronectin type-III 5
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1131476_15720674.0DomainFibronectin type-III 6
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113156_1680674.0DomainEGF-like 1%3B incomplete
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1131574_16690674.0DomainFibronectin type-III 7
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1131674_17640674.0DomainFibronectin type-III 8
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1131778_18680674.0DomainFibronectin type-III 9
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113183_2130674.0DomainEGF-like 2
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1131883_19710674.0DomainFibronectin type-III 10
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1131989_20890674.0DomainFibronectin type-III 11
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1132097_21850674.0DomainFibronectin type-III 12
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113214_2440674.0DomainEGF-like 3
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1132196_22960674.0DomainFibronectin type-III 13
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1132305_23980674.0DomainFibronectin type-III 14
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1132408_25020674.0DomainFibronectin type-III 15
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113245_2750674.0DomainEGF-like 4
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1132519_26170674.0DomainFibronectin type-III 16
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1132625_27230674.0DomainFibronectin type-III 17
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1132733_28400674.0DomainFibronectin type-III 18
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113276_3060674.0DomainEGF-like 5
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1132841_29390674.0DomainFibronectin type-III 19
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1132949_30420674.0DomainFibronectin type-III 20
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1133062_31530674.0DomainFibronectin type-III 21
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113307_3370674.0DomainEGF-like 6
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1133168_32600674.0DomainFibronectin type-III 22
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1133264_33550674.0DomainFibronectin type-III 23
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1133357_34460674.0DomainFibronectin type-III 24
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113338_3680674.0DomainEGF-like 7
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1133451_35440674.0DomainFibronectin type-III 25
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1133553_36470674.0DomainFibronectin type-III 26
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1133657_37540674.0DomainFibronectin type-III 27
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113369_3990674.0DomainEGF-like 8
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1133758_38470674.0DomainFibronectin type-III 28
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1133848_39340674.0DomainFibronectin type-III 29
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1133935_40250674.0DomainFibronectin type-III 30
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113400_4300674.0DomainEGF-like 9
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1134021_42360674.0DomainFibrinogen C-terminal
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113431_4610674.0DomainEGF-like 10
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113462_4920674.0DomainEGF-like 11
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113493_5230674.0DomainEGF-like 12
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113524_5540674.0DomainEGF-like 13
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113555_5850674.0DomainEGF-like 14
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113586_6160674.0DomainEGF-like 15
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113617_6470674.0DomainEGF-like 16
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113648_6790674.0DomainEGF-like 17
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113684_7140674.0DomainEGF-like 18
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113715_7460674.0DomainEGF-like 19
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-113959_10510674.0DomainFibronectin type-III 1
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1151064_11530674.0DomainFibronectin type-III 2
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1151161_12490674.0DomainFibronectin type-III 3
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1151263_13520674.0DomainFibronectin type-III 4
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1151374_14680674.0DomainFibronectin type-III 5
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1151476_15720674.0DomainFibronectin type-III 6
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115156_1680674.0DomainEGF-like 1%3B incomplete
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1151574_16690674.0DomainFibronectin type-III 7
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1151674_17640674.0DomainFibronectin type-III 8
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1151778_18680674.0DomainFibronectin type-III 9
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115183_2130674.0DomainEGF-like 2
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1151883_19710674.0DomainFibronectin type-III 10
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1151989_20890674.0DomainFibronectin type-III 11
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1152097_21850674.0DomainFibronectin type-III 12
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115214_2440674.0DomainEGF-like 3
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1152196_22960674.0DomainFibronectin type-III 13
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1152305_23980674.0DomainFibronectin type-III 14
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1152408_25020674.0DomainFibronectin type-III 15
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115245_2750674.0DomainEGF-like 4
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1152519_26170674.0DomainFibronectin type-III 16
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1152625_27230674.0DomainFibronectin type-III 17
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1152733_28400674.0DomainFibronectin type-III 18
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115276_3060674.0DomainEGF-like 5
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1152841_29390674.0DomainFibronectin type-III 19
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1152949_30420674.0DomainFibronectin type-III 20
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1153062_31530674.0DomainFibronectin type-III 21
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115307_3370674.0DomainEGF-like 6
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1153168_32600674.0DomainFibronectin type-III 22
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1153264_33550674.0DomainFibronectin type-III 23
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1153357_34460674.0DomainFibronectin type-III 24
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115338_3680674.0DomainEGF-like 7
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1153451_35440674.0DomainFibronectin type-III 25
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1153553_36470674.0DomainFibronectin type-III 26
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1153657_37540674.0DomainFibronectin type-III 27
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115369_3990674.0DomainEGF-like 8
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1153758_38470674.0DomainFibronectin type-III 28
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1153848_39340674.0DomainFibronectin type-III 29
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1153935_40250674.0DomainFibronectin type-III 30
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115400_4300674.0DomainEGF-like 9
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1154021_42360674.0DomainFibrinogen C-terminal
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115431_4610674.0DomainEGF-like 10
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115462_4920674.0DomainEGF-like 11
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115493_5230674.0DomainEGF-like 12
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115524_5540674.0DomainEGF-like 13
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115555_5850674.0DomainEGF-like 14
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115586_6160674.0DomainEGF-like 15
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115617_6470674.0DomainEGF-like 16
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115648_6790674.0DomainEGF-like 17
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115684_7140674.0DomainEGF-like 18
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115715_7460674.0DomainEGF-like 19
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-115959_10510674.0DomainFibronectin type-III 1
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1151064_11530674.0DomainFibronectin type-III 2
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1151161_12490674.0DomainFibronectin type-III 3
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1151263_13520674.0DomainFibronectin type-III 4
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1151374_14680674.0DomainFibronectin type-III 5
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1151476_15720674.0DomainFibronectin type-III 6
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115156_1680674.0DomainEGF-like 1%3B incomplete
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1151574_16690674.0DomainFibronectin type-III 7
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1151674_17640674.0DomainFibronectin type-III 8
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1151778_18680674.0DomainFibronectin type-III 9
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115183_2130674.0DomainEGF-like 2
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1151883_19710674.0DomainFibronectin type-III 10
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1151989_20890674.0DomainFibronectin type-III 11
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1152097_21850674.0DomainFibronectin type-III 12
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115214_2440674.0DomainEGF-like 3
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1152196_22960674.0DomainFibronectin type-III 13
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1152305_23980674.0DomainFibronectin type-III 14
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1152408_25020674.0DomainFibronectin type-III 15
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115245_2750674.0DomainEGF-like 4
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1152519_26170674.0DomainFibronectin type-III 16
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1152625_27230674.0DomainFibronectin type-III 17
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1152733_28400674.0DomainFibronectin type-III 18
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115276_3060674.0DomainEGF-like 5
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1152841_29390674.0DomainFibronectin type-III 19
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1152949_30420674.0DomainFibronectin type-III 20
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1153062_31530674.0DomainFibronectin type-III 21
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115307_3370674.0DomainEGF-like 6
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1153168_32600674.0DomainFibronectin type-III 22
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1153264_33550674.0DomainFibronectin type-III 23
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1153357_34460674.0DomainFibronectin type-III 24
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115338_3680674.0DomainEGF-like 7
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1153451_35440674.0DomainFibronectin type-III 25
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1153553_36470674.0DomainFibronectin type-III 26
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1153657_37540674.0DomainFibronectin type-III 27
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115369_3990674.0DomainEGF-like 8
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1153758_38470674.0DomainFibronectin type-III 28
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1153848_39340674.0DomainFibronectin type-III 29
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1153935_40250674.0DomainFibronectin type-III 30
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115400_4300674.0DomainEGF-like 9
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1154021_42360674.0DomainFibrinogen C-terminal
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115431_4610674.0DomainEGF-like 10
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115462_4920674.0DomainEGF-like 11
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115493_5230674.0DomainEGF-like 12
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115524_5540674.0DomainEGF-like 13
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115555_5850674.0DomainEGF-like 14
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115586_6160674.0DomainEGF-like 15
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115617_6470674.0DomainEGF-like 16
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115648_6790674.0DomainEGF-like 17
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115684_7140674.0DomainEGF-like 18
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115715_7460674.0DomainEGF-like 19
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-115959_10510674.0DomainFibronectin type-III 1
HgeneTNXBchr6:32016140chr10:17278293ENST00000451343-1131666_16680674.0MotifCell attachment site
HgeneTNXBchr6:32016140chr10:17278293ENST00000546684-1151666_16680674.0MotifCell attachment site
HgeneTNXBchr6:32016140chr10:17278293ENST00000550539-1151666_16680674.0MotifCell attachment site
TgeneVIMchr6:32016140chr10:17278293ENST0000022423769154_245424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr6:32016140chr10:17278293ENST0000022423769303_407424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr6:32016140chr10:17278293ENST000002242376996_131424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr6:32016140chr10:17278293ENST00000544301710154_245424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr6:32016140chr10:17278293ENST00000544301710303_407424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr6:32016140chr10:17278293ENST0000054430171096_131424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr6:32016140chr10:17278293ENST0000022423769103_411424.3333333333333467.0DomainIF rod
TgeneVIMchr6:32016140chr10:17278293ENST00000544301710103_411424.3333333333333467.0DomainIF rod
TgeneVIMchr6:32016140chr10:17278293ENST0000022423769326_329424.3333333333333467.0Motif[IL]-x-C-x-x-[DE] motif
TgeneVIMchr6:32016140chr10:17278293ENST00000544301710326_329424.3333333333333467.0Motif[IL]-x-C-x-x-[DE] motif
TgeneVIMchr6:32016140chr10:17278293ENST0000022423769132_153424.3333333333333467.0RegionNote=Linker 1
TgeneVIMchr6:32016140chr10:17278293ENST0000022423769246_268424.3333333333333467.0RegionNote=Linker 12
TgeneVIMchr6:32016140chr10:17278293ENST0000022423769269_407424.3333333333333467.0RegionNote=Coil 2
TgeneVIMchr6:32016140chr10:17278293ENST00000224237692_95424.3333333333333467.0RegionNote=Head
TgeneVIMchr6:32016140chr10:17278293ENST0000022423769408_466424.3333333333333467.0RegionNote=Tail
TgeneVIMchr6:32016140chr10:17278293ENST00000544301710132_153424.3333333333333467.0RegionNote=Linker 1
TgeneVIMchr6:32016140chr10:17278293ENST00000544301710246_268424.3333333333333467.0RegionNote=Linker 12
TgeneVIMchr6:32016140chr10:17278293ENST00000544301710269_407424.3333333333333467.0RegionNote=Coil 2
TgeneVIMchr6:32016140chr10:17278293ENST000005443017102_95424.3333333333333467.0RegionNote=Head
TgeneVIMchr6:32016140chr10:17278293ENST00000544301710408_466424.3333333333333467.0RegionNote=Tail


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TNXB
VIM


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TNXB-VIM


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TNXB-VIM


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource