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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TP73-CEP104

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TP73-CEP104
FusionPDB ID: 93255
FusionGDB2.0 ID: 93255
HgeneTgene
Gene symbol

TP73

CEP104

Gene ID

7161

9731

Gene nametumor protein p73centrosomal protein 104
SynonymsP73CFAP256|GlyBP|JBTS25|KIAA0562|ROC22
Cytomap

1p36.32

1p36.32

Type of geneprotein-codingprotein-coding
Descriptiontumor protein p73p53-like transcription factorp53-related proteincentrosomal protein of 104 kDacentrosomal protein 104kDa
Modification date2020032720200313
UniProtAcc.

O60308

Ensembl transtripts involved in fusion geneENST idsENST00000346387, ENST00000354437, 
ENST00000357733, ENST00000378295, 
ENST00000603362, ENST00000604074, 
ENST00000604479, ENST00000378280, 
ENST00000378285, ENST00000378288, 
ENST00000378290, 		ENST00000378223, 
ENST00000378230, ENST00000460038, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 2 X 3=124 X 5 X 5=100
# samples 35
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TP73 [Title/Abstract] AND CEP104 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TP73(3599744)-CEP104(3740126), # samples:1
TP73(3599744)-CEP104(3768985), # samples:1
Anticipated loss of major functional domain due to fusion event.TP73-CEP104 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TP73-CEP104 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TP73-CEP104 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TP73-CEP104 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTP73

GO:0006974

cellular response to DNA damage stimulus

18174154

HgeneTP73

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

18174154|19490146

HgeneTP73

GO:0045893

positive regulation of transcription, DNA-templated

15678106|16343436

HgeneTP73

GO:0045944

positive regulation of transcription by RNA polymerase II

16343436|18174154|18421303|19490146|24652652

HgeneTP73

GO:0071158

positive regulation of cell cycle arrest

18421303


check buttonFusion gene breakpoints across TP73 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEP104 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-A5RA-01ATP73chr1

3599744

-CEP104chr1

3768985

-
ChimerDB4OVTCGA-13-0899TP73chr1

3599744

+CEP104chr1

3740126

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000378295TP73chr13599744+ENST00000378230CEP104chr13740126-4076341107754215
ENST00000604074TP73chr13599744+ENST00000378230CEP104chr13740126-4076341107754215
ENST00000354437TP73chr13599744+ENST00000378230CEP104chr13740126-403129662709215
ENST00000346387TP73chr13599744+ENST00000378230CEP104chr13740126-403129662709215
ENST00000357733TP73chr13599744+ENST00000378230CEP104chr13740126-403129662709215
ENST00000603362TP73chr13599744+ENST00000378230CEP104chr13740126-39211860599199
ENST00000604479TP73chr13599744+ENST00000378230CEP104chr13740126-39211860599199

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378295ENST00000378230TP73chr13599744+CEP104chr13740126-0.0281866940.9718133
ENST00000604074ENST00000378230TP73chr13599744+CEP104chr13740126-0.0281866940.9718133
ENST00000354437ENST00000378230TP73chr13599744+CEP104chr13740126-0.0258698220.97413015
ENST00000346387ENST00000378230TP73chr13599744+CEP104chr13740126-0.0258698220.97413015
ENST00000357733ENST00000378230TP73chr13599744+CEP104chr13740126-0.0258698220.97413015
ENST00000603362ENST00000378230TP73chr13599744+CEP104chr13740126-0.0246631170.97533685
ENST00000604479ENST00000378230TP73chr13599744+CEP104chr13740126-0.0246631170.97533685

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>93255_93255_1_TP73-CEP104_TP73_chr1_3599744_ENST00000346387_CEP104_chr1_3740126_ENST00000378230_length(amino acids)=215AA_BP=78
MRRLQSELPSEAGVGKMAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMVVEISSLTEHLL
TECDKKDGFGKCYRCSEAVFKEELPRHIKHKDCNPAKPEKLANRCPLCHENFSPGEEAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKS

--------------------------------------------------------------

>93255_93255_2_TP73-CEP104_TP73_chr1_3599744_ENST00000354437_CEP104_chr1_3740126_ENST00000378230_length(amino acids)=215AA_BP=78
MRRLQSELPSEAGVGKMAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMVVEISSLTEHLL
TECDKKDGFGKCYRCSEAVFKEELPRHIKHKDCNPAKPEKLANRCPLCHENFSPGEEAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKS

--------------------------------------------------------------

>93255_93255_3_TP73-CEP104_TP73_chr1_3599744_ENST00000357733_CEP104_chr1_3740126_ENST00000378230_length(amino acids)=215AA_BP=78
MRRLQSELPSEAGVGKMAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMVVEISSLTEHLL
TECDKKDGFGKCYRCSEAVFKEELPRHIKHKDCNPAKPEKLANRCPLCHENFSPGEEAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKS

--------------------------------------------------------------

>93255_93255_4_TP73-CEP104_TP73_chr1_3599744_ENST00000378295_CEP104_chr1_3740126_ENST00000378230_length(amino acids)=215AA_BP=78
MRRLQSELPSEAGVGKMAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMVVEISSLTEHLL
TECDKKDGFGKCYRCSEAVFKEELPRHIKHKDCNPAKPEKLANRCPLCHENFSPGEEAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKS

--------------------------------------------------------------

>93255_93255_5_TP73-CEP104_TP73_chr1_3599744_ENST00000603362_CEP104_chr1_3740126_ENST00000378230_length(amino acids)=199AA_BP=62
MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMVVEISSLTEHLLTECDKKDGFGKCYRCS
EAVFKEELPRHIKHKDCNPAKPEKLANRCPLCHENFSPGEEAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKSSAVAASGPLGSKAGSK

--------------------------------------------------------------

>93255_93255_6_TP73-CEP104_TP73_chr1_3599744_ENST00000604074_CEP104_chr1_3740126_ENST00000378230_length(amino acids)=215AA_BP=78
MRRLQSELPSEAGVGKMAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMVVEISSLTEHLL
TECDKKDGFGKCYRCSEAVFKEELPRHIKHKDCNPAKPEKLANRCPLCHENFSPGEEAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKS

--------------------------------------------------------------

>93255_93255_7_TP73-CEP104_TP73_chr1_3599744_ENST00000604479_CEP104_chr1_3740126_ENST00000378230_length(amino acids)=199AA_BP=62
MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMVVEISSLTEHLLTECDKKDGFGKCYRCS
EAVFKEELPRHIKHKDCNPAKPEKLANRCPLCHENFSPGEEAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKSSAVAASGPLGSKAGSK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:3599744/chr1:3740126)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CEP104

O60308

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Required for ciliogenesis and for structural integrity at the ciliary tip. {ECO:0000269|PubMed:23970417}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTP73chr1:3599744chr1:3740126ENST00000346387+3121_5562.0541.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneTP73chr1:3599744chr1:3740126ENST00000354437+3131_5562.0500.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneTP73chr1:3599744chr1:3740126ENST00000378295+3141_5562.0637.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneTP73chr1:3599744chr1:3740126ENST00000604074+3111_5562.0404.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneTP73chr1:3599744chr1:3740126ENST00000604479+2111_5562.0541.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneTP73chr1:3599744chr1:3740126ENST00000346387+3121_4662.0541.0RegionTransactivation
HgeneTP73chr1:3599744chr1:3740126ENST00000354437+3131_4662.0500.0RegionTransactivation
HgeneTP73chr1:3599744chr1:3740126ENST00000378295+3141_4662.0637.0RegionTransactivation
HgeneTP73chr1:3599744chr1:3740126ENST00000604074+3111_4662.0404.0RegionTransactivation
HgeneTP73chr1:3599744chr1:3740126ENST00000604479+2111_4662.0541.0RegionTransactivation
TgeneCEP104chr1:3599744chr1:3740126ENST0000037822307209_2890245.0Coiled coilOntology_term=ECO:0000255
TgeneCEP104chr1:3599744chr1:3740126ENST0000037822307677_7250245.0Coiled coilOntology_term=ECO:0000255
TgeneCEP104chr1:3599744chr1:3740126ENST0000037822307529_5670245.0RepeatNote=HEAT 1
TgeneCEP104chr1:3599744chr1:3740126ENST0000037822307604_6400245.0RepeatNote=HEAT 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTP73chr1:3599744chr1:3740126ENST00000346387+312168_17162.0541.0Compositional biasNote=Poly-Pro
HgeneTP73chr1:3599744chr1:3740126ENST00000346387+312391_39462.0541.0Compositional biasNote=Poly-Gln
HgeneTP73chr1:3599744chr1:3740126ENST00000346387+312483_48662.0541.0Compositional biasNote=Poly-Pro
HgeneTP73chr1:3599744chr1:3740126ENST00000354437+313168_17162.0500.0Compositional biasNote=Poly-Pro
HgeneTP73chr1:3599744chr1:3740126ENST00000354437+313391_39462.0500.0Compositional biasNote=Poly-Gln
HgeneTP73chr1:3599744chr1:3740126ENST00000354437+313483_48662.0500.0Compositional biasNote=Poly-Pro
HgeneTP73chr1:3599744chr1:3740126ENST00000378280+111168_1710518.0Compositional biasNote=Poly-Pro
HgeneTP73chr1:3599744chr1:3740126ENST00000378280+1111_550518.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneTP73chr1:3599744chr1:3740126ENST00000378280+111391_3940518.0Compositional biasNote=Poly-Gln
HgeneTP73chr1:3599744chr1:3740126ENST00000378280+111483_4860518.0Compositional biasNote=Poly-Pro
HgeneTP73chr1:3599744chr1:3740126ENST00000378285+111168_1710451.0Compositional biasNote=Poly-Pro
HgeneTP73chr1:3599744chr1:3740126ENST00000378285+1111_550451.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneTP73chr1:3599744chr1:3740126ENST00000378285+111391_3940451.0Compositional biasNote=Poly-Gln
HgeneTP73chr1:3599744chr1:3740126ENST00000378285+111483_4860451.0Compositional biasNote=Poly-Pro
HgeneTP73chr1:3599744chr1:3740126ENST00000378288+112168_1710588.0Compositional biasNote=Poly-Pro
HgeneTP73chr1:3599744chr1:3740126ENST00000378288+1121_550588.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneTP73chr1:3599744chr1:3740126ENST00000378288+112391_3940588.0Compositional biasNote=Poly-Gln
HgeneTP73chr1:3599744chr1:3740126ENST00000378288+112483_4860588.0Compositional biasNote=Poly-Pro
HgeneTP73chr1:3599744chr1:3740126ENST00000378290+112168_1710566.0Compositional biasNote=Poly-Pro
HgeneTP73chr1:3599744chr1:3740126ENST00000378290+1121_550566.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneTP73chr1:3599744chr1:3740126ENST00000378290+112391_3940566.0Compositional biasNote=Poly-Gln
HgeneTP73chr1:3599744chr1:3740126ENST00000378290+112483_4860566.0Compositional biasNote=Poly-Pro
HgeneTP73chr1:3599744chr1:3740126ENST00000378295+314168_17162.0637.0Compositional biasNote=Poly-Pro
HgeneTP73chr1:3599744chr1:3740126ENST00000378295+314391_39462.0637.0Compositional biasNote=Poly-Gln
HgeneTP73chr1:3599744chr1:3740126ENST00000378295+314483_48662.0637.0Compositional biasNote=Poly-Pro
HgeneTP73chr1:3599744chr1:3740126ENST00000604074+311168_17162.0404.0Compositional biasNote=Poly-Pro
HgeneTP73chr1:3599744chr1:3740126ENST00000604074+311391_39462.0404.0Compositional biasNote=Poly-Gln
HgeneTP73chr1:3599744chr1:3740126ENST00000604074+311483_48662.0404.0Compositional biasNote=Poly-Pro
HgeneTP73chr1:3599744chr1:3740126ENST00000604479+211168_17162.0541.0Compositional biasNote=Poly-Pro
HgeneTP73chr1:3599744chr1:3740126ENST00000604479+211391_39462.0541.0Compositional biasNote=Poly-Gln
HgeneTP73chr1:3599744chr1:3740126ENST00000604479+211483_48662.0541.0Compositional biasNote=Poly-Pro
HgeneTP73chr1:3599744chr1:3740126ENST00000346387+312485_55162.0541.0DomainNote=SAM
HgeneTP73chr1:3599744chr1:3740126ENST00000354437+313485_55162.0500.0DomainNote=SAM
HgeneTP73chr1:3599744chr1:3740126ENST00000378280+111485_5510518.0DomainNote=SAM
HgeneTP73chr1:3599744chr1:3740126ENST00000378285+111485_5510451.0DomainNote=SAM
HgeneTP73chr1:3599744chr1:3740126ENST00000378288+112485_5510588.0DomainNote=SAM
HgeneTP73chr1:3599744chr1:3740126ENST00000378290+112485_5510566.0DomainNote=SAM
HgeneTP73chr1:3599744chr1:3740126ENST00000378295+314485_55162.0637.0DomainNote=SAM
HgeneTP73chr1:3599744chr1:3740126ENST00000604074+311485_55162.0404.0DomainNote=SAM
HgeneTP73chr1:3599744chr1:3740126ENST00000604479+211485_55162.0541.0DomainNote=SAM
HgeneTP73chr1:3599744chr1:3740126ENST00000346387+312483_48762.0541.0MotifNote=PPxY motif
HgeneTP73chr1:3599744chr1:3740126ENST00000354437+313483_48762.0500.0MotifNote=PPxY motif
HgeneTP73chr1:3599744chr1:3740126ENST00000378280+111483_4870518.0MotifNote=PPxY motif
HgeneTP73chr1:3599744chr1:3740126ENST00000378285+111483_4870451.0MotifNote=PPxY motif
HgeneTP73chr1:3599744chr1:3740126ENST00000378288+112483_4870588.0MotifNote=PPxY motif
HgeneTP73chr1:3599744chr1:3740126ENST00000378290+112483_4870566.0MotifNote=PPxY motif
HgeneTP73chr1:3599744chr1:3740126ENST00000378295+314483_48762.0637.0MotifNote=PPxY motif
HgeneTP73chr1:3599744chr1:3740126ENST00000604074+311483_48762.0404.0MotifNote=PPxY motif
HgeneTP73chr1:3599744chr1:3740126ENST00000604479+211483_48762.0541.0MotifNote=PPxY motif
HgeneTP73chr1:3599744chr1:3740126ENST00000346387+312131_31062.0541.0RegionDNA-binding
HgeneTP73chr1:3599744chr1:3740126ENST00000346387+312345_38662.0541.0RegionOligomerization
HgeneTP73chr1:3599744chr1:3740126ENST00000354437+313131_31062.0500.0RegionDNA-binding
HgeneTP73chr1:3599744chr1:3740126ENST00000354437+313345_38662.0500.0RegionOligomerization
HgeneTP73chr1:3599744chr1:3740126ENST00000378280+111131_3100518.0RegionDNA-binding
HgeneTP73chr1:3599744chr1:3740126ENST00000378280+1111_460518.0RegionTransactivation
HgeneTP73chr1:3599744chr1:3740126ENST00000378280+111345_3860518.0RegionOligomerization
HgeneTP73chr1:3599744chr1:3740126ENST00000378285+111131_3100451.0RegionDNA-binding
HgeneTP73chr1:3599744chr1:3740126ENST00000378285+1111_460451.0RegionTransactivation
HgeneTP73chr1:3599744chr1:3740126ENST00000378285+111345_3860451.0RegionOligomerization
HgeneTP73chr1:3599744chr1:3740126ENST00000378288+112131_3100588.0RegionDNA-binding
HgeneTP73chr1:3599744chr1:3740126ENST00000378288+1121_460588.0RegionTransactivation
HgeneTP73chr1:3599744chr1:3740126ENST00000378288+112345_3860588.0RegionOligomerization
HgeneTP73chr1:3599744chr1:3740126ENST00000378290+112131_3100566.0RegionDNA-binding
HgeneTP73chr1:3599744chr1:3740126ENST00000378290+1121_460566.0RegionTransactivation
HgeneTP73chr1:3599744chr1:3740126ENST00000378290+112345_3860566.0RegionOligomerization
HgeneTP73chr1:3599744chr1:3740126ENST00000378295+314131_31062.0637.0RegionDNA-binding
HgeneTP73chr1:3599744chr1:3740126ENST00000378295+314345_38662.0637.0RegionOligomerization
HgeneTP73chr1:3599744chr1:3740126ENST00000604074+311131_31062.0404.0RegionDNA-binding
HgeneTP73chr1:3599744chr1:3740126ENST00000604074+311345_38662.0404.0RegionOligomerization
HgeneTP73chr1:3599744chr1:3740126ENST00000604479+211131_31062.0541.0RegionDNA-binding
HgeneTP73chr1:3599744chr1:3740126ENST00000604479+211345_38662.0541.0RegionOligomerization
TgeneCEP104chr1:3599744chr1:3740126ENST000003782301722209_289788.0926.0Coiled coilOntology_term=ECO:0000255
TgeneCEP104chr1:3599744chr1:3740126ENST000003782301722677_725788.0926.0Coiled coilOntology_term=ECO:0000255
TgeneCEP104chr1:3599744chr1:3740126ENST000003782301722529_567788.0926.0RepeatNote=HEAT 1
TgeneCEP104chr1:3599744chr1:3740126ENST000003782301722604_640788.0926.0RepeatNote=HEAT 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TP73
CEP104


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTP73chr1:3599744chr1:3740126ENST00000346387+312345_38062.0541.0HIPK2
HgeneTP73chr1:3599744chr1:3740126ENST00000354437+313345_38062.0500.0HIPK2
HgeneTP73chr1:3599744chr1:3740126ENST00000378280+111345_3800518.0HIPK2
HgeneTP73chr1:3599744chr1:3740126ENST00000378285+111345_3800451.0HIPK2
HgeneTP73chr1:3599744chr1:3740126ENST00000378288+112345_3800588.0HIPK2
HgeneTP73chr1:3599744chr1:3740126ENST00000378290+112345_3800566.0HIPK2
HgeneTP73chr1:3599744chr1:3740126ENST00000378295+314345_38062.0637.0HIPK2
HgeneTP73chr1:3599744chr1:3740126ENST00000604074+311345_38062.0404.0HIPK2
HgeneTP73chr1:3599744chr1:3740126ENST00000604479+211345_38062.0541.0HIPK2


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Related Drugs to TP73-CEP104


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TP73-CEP104


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource