UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TPM4-NTRK1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TPM4-NTRK1
	FusionPDB ID: 93411
	FusionGDB2.0 ID: 93411
		Hgene	Tgene
	Gene symbol	TPM4	NTRK1
	Gene ID	7171	4914
	Gene name	tropomyosin 4	neurotrophic receptor tyrosine kinase 1
	Synonyms	HEL-S-108	MTC\|TRK\|TRK1\|TRKA\|Trk-A\|p140-TrkA
	Cytomap	19p13.12-p13.11	1q23.1
	Type of gene	protein-coding	protein-coding
	Description	tropomyosin alpha-4 chainTM30p1epididymis secretory protein Li 108	high affinity nerve growth factor receptorOncogene TRKTRK1-transforming tyrosine kinase proteingp140trkneurotrophic tyrosine kinase, receptor, type 1tropomyosin-related kinase Atyrosine kinase receptor A
	Modification date	20200320	20200313
	UniProtAcc	P67936	P04629
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000591645, ENST00000300933, ENST00000344824, ENST00000538887,	ENST00000358660, ENST00000368196, ENST00000392302, ENST00000524377, ENST00000531606,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	22 X 19 X 9=3762	25 X 24 X 13=7800
	# samples	25	33
	** MAII score	log2(25/3762*10)=-3.91149984886111 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(33/7800*10)=-4.56293619439116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TPM4 [Title/Abstract] AND NTRK1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TPM4(16204563)-NTRK1(156845311), # samples:1 TPM4(16204563)-NTRK1(156845871), # samples:1 TPM4(16204563)-NTRK1(156844362), # samples:1
Anticipated loss of major functional domain due to fusion event.	TPM4-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TPM4-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TPM4-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TPM4-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NTRK1	GO:0006468	protein phosphorylation	15488758
Tgene	NTRK1	GO:0008285	negative regulation of cell proliferation	15488758
Tgene	NTRK1	GO:0010976	positive regulation of neuron projection development	15488758
Tgene	NTRK1	GO:0018108	peptidyl-tyrosine phosphorylation	2927393
Tgene	NTRK1	GO:0043547	positive regulation of GTPase activity	15488758
Tgene	NTRK1	GO:0046579	positive regulation of Ras protein signal transduction	15488758
Tgene	NTRK1	GO:0046777	protein autophosphorylation	15488758
Tgene	NTRK1	GO:0048011	neurotrophin TRK receptor signaling pathway	15488758
Tgene	NTRK1	GO:0051092	positive regulation of NF-kappaB transcription factor activity	15488758
Tgene	NTRK1	GO:0070374	positive regulation of ERK1 and ERK2 cascade	15488758
Tgene	NTRK1	GO:1904646	cellular response to amyloid-beta	11927634

Fusion gene breakpoints across TPM4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NTRK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A3UA	TPM4	chr19	16204563	+	NTRK1	chr1	156845311	+
ChimerDB4	SARC	TCGA-DX-A3UA	TPM4	chr19	16204563	+	NTRK1	chr1	156845871	+
ChimerDB4	THCA	TCGA-EL-A3D4	TPM4	chr19	16204563	+	NTRK1	chr1	156844362	+

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000344824	TPM4	chr19	16204563	+	ENST00000392302	NTRK1	chr1	156845311	+	2079	890	58	1926	622
ENST00000344824	TPM4	chr19	16204563	+	ENST00000368196	NTRK1	chr1	156845311	+	2135	890	58	1926	622
ENST00000344824	TPM4	chr19	16204563	+	ENST00000524377	NTRK1	chr1	156845311	+	1927	890	58	1926	623
ENST00000344824	TPM4	chr19	16204563	+	ENST00000358660	NTRK1	chr1	156845311	+	2005	890	58	1935	625
ENST00000538887	TPM4	chr19	16204563	+	ENST00000392302	NTRK1	chr1	156845311	+	2048	859	27	1895	622
ENST00000538887	TPM4	chr19	16204563	+	ENST00000368196	NTRK1	chr1	156845311	+	2104	859	27	1895	622
ENST00000538887	TPM4	chr19	16204563	+	ENST00000524377	NTRK1	chr1	156845311	+	1896	859	27	1895	622
ENST00000538887	TPM4	chr19	16204563	+	ENST00000358660	NTRK1	chr1	156845311	+	1974	859	27	1904	625
ENST00000300933	TPM4	chr19	16204563	+	ENST00000392302	NTRK1	chr1	156845311	+	2113	924	29	1960	643
ENST00000300933	TPM4	chr19	16204563	+	ENST00000368196	NTRK1	chr1	156845311	+	2169	924	29	1960	643
ENST00000300933	TPM4	chr19	16204563	+	ENST00000524377	NTRK1	chr1	156845311	+	1961	924	29	1960	644
ENST00000300933	TPM4	chr19	16204563	+	ENST00000358660	NTRK1	chr1	156845311	+	2039	924	29	1969	646
ENST00000344824	TPM4	chr19	16204563	+	ENST00000392302	NTRK1	chr1	156845871	+	1932	890	58	1779	573
ENST00000344824	TPM4	chr19	16204563	+	ENST00000368196	NTRK1	chr1	156845871	+	1988	890	58	1779	573
ENST00000344824	TPM4	chr19	16204563	+	ENST00000524377	NTRK1	chr1	156845871	+	1780	890	58	1779	574
ENST00000344824	TPM4	chr19	16204563	+	ENST00000358660	NTRK1	chr1	156845871	+	1849	890	58	1779	573
ENST00000538887	TPM4	chr19	16204563	+	ENST00000392302	NTRK1	chr1	156845871	+	1901	859	27	1748	573
ENST00000538887	TPM4	chr19	16204563	+	ENST00000368196	NTRK1	chr1	156845871	+	1957	859	27	1748	573
ENST00000538887	TPM4	chr19	16204563	+	ENST00000524377	NTRK1	chr1	156845871	+	1749	859	27	1748	573
ENST00000538887	TPM4	chr19	16204563	+	ENST00000358660	NTRK1	chr1	156845871	+	1818	859	27	1748	573
ENST00000300933	TPM4	chr19	16204563	+	ENST00000392302	NTRK1	chr1	156845871	+	1966	924	29	1813	594
ENST00000300933	TPM4	chr19	16204563	+	ENST00000368196	NTRK1	chr1	156845871	+	2022	924	29	1813	594
ENST00000300933	TPM4	chr19	16204563	+	ENST00000524377	NTRK1	chr1	156845871	+	1814	924	29	1813	595
ENST00000300933	TPM4	chr19	16204563	+	ENST00000358660	NTRK1	chr1	156845871	+	1883	924	29	1813	594
ENST00000344824	TPM4	chr19	16204563	+	ENST00000392302	NTRK1	chr1	156844362	+	2238	890	58	2085	675
ENST00000344824	TPM4	chr19	16204563	+	ENST00000368196	NTRK1	chr1	156844362	+	2294	890	58	2085	675
ENST00000344824	TPM4	chr19	16204563	+	ENST00000524377	NTRK1	chr1	156844362	+	2086	890	58	2085	676
ENST00000344824	TPM4	chr19	16204563	+	ENST00000358660	NTRK1	chr1	156844362	+	2164	890	58	2094	678
ENST00000538887	TPM4	chr19	16204563	+	ENST00000392302	NTRK1	chr1	156844362	+	2207	859	27	2054	675
ENST00000538887	TPM4	chr19	16204563	+	ENST00000368196	NTRK1	chr1	156844362	+	2263	859	27	2054	675
ENST00000538887	TPM4	chr19	16204563	+	ENST00000524377	NTRK1	chr1	156844362	+	2055	859	27	2054	675
ENST00000538887	TPM4	chr19	16204563	+	ENST00000358660	NTRK1	chr1	156844362	+	2133	859	27	2063	678
ENST00000300933	TPM4	chr19	16204563	+	ENST00000392302	NTRK1	chr1	156844362	+	2272	924	29	2119	696
ENST00000300933	TPM4	chr19	16204563	+	ENST00000368196	NTRK1	chr1	156844362	+	2328	924	29	2119	696
ENST00000300933	TPM4	chr19	16204563	+	ENST00000524377	NTRK1	chr1	156844362	+	2120	924	29	2119	697
ENST00000300933	TPM4	chr19	16204563	+	ENST00000358660	NTRK1	chr1	156844362	+	2198	924	29	2128	699

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000344824	ENST00000392302	TPM4	chr19	16204563	+	NTRK1	chr1	156845311	+	0.008812213	0.9911878
ENST00000344824	ENST00000368196	TPM4	chr19	16204563	+	NTRK1	chr1	156845311	+	0.008390485	0.9916095
ENST00000344824	ENST00000524377	TPM4	chr19	16204563	+	NTRK1	chr1	156845311	+	0.008906594	0.99109346
ENST00000344824	ENST00000358660	TPM4	chr19	16204563	+	NTRK1	chr1	156845311	+	0.009621481	0.9903785
ENST00000538887	ENST00000392302	TPM4	chr19	16204563	+	NTRK1	chr1	156845311	+	0.008879779	0.9911203
ENST00000538887	ENST00000368196	TPM4	chr19	16204563	+	NTRK1	chr1	156845311	+	0.008409904	0.9915901
ENST00000538887	ENST00000524377	TPM4	chr19	16204563	+	NTRK1	chr1	156845311	+	0.009016261	0.9909837
ENST00000538887	ENST00000358660	TPM4	chr19	16204563	+	NTRK1	chr1	156845311	+	0.009684945	0.990315
ENST00000300933	ENST00000392302	TPM4	chr19	16204563	+	NTRK1	chr1	156845311	+	0.012892977	0.987107
ENST00000300933	ENST00000368196	TPM4	chr19	16204563	+	NTRK1	chr1	156845311	+	0.012581601	0.9874184
ENST00000300933	ENST00000524377	TPM4	chr19	16204563	+	NTRK1	chr1	156845311	+	0.01334206	0.9866579
ENST00000300933	ENST00000358660	TPM4	chr19	16204563	+	NTRK1	chr1	156845311	+	0.014596606	0.9854034
ENST00000344824	ENST00000392302	TPM4	chr19	16204563	+	NTRK1	chr1	156845871	+	0.006403816	0.9935962
ENST00000344824	ENST00000368196	TPM4	chr19	16204563	+	NTRK1	chr1	156845871	+	0.006257534	0.9937424
ENST00000344824	ENST00000524377	TPM4	chr19	16204563	+	NTRK1	chr1	156845871	+	0.006509149	0.9934909
ENST00000344824	ENST00000358660	TPM4	chr19	16204563	+	NTRK1	chr1	156845871	+	0.006396844	0.99360317
ENST00000538887	ENST00000392302	TPM4	chr19	16204563	+	NTRK1	chr1	156845871	+	0.006495504	0.9935045
ENST00000538887	ENST00000368196	TPM4	chr19	16204563	+	NTRK1	chr1	156845871	+	0.006186881	0.99381316
ENST00000538887	ENST00000524377	TPM4	chr19	16204563	+	NTRK1	chr1	156845871	+	0.0065583	0.9934417
ENST00000538887	ENST00000358660	TPM4	chr19	16204563	+	NTRK1	chr1	156845871	+	0.006496291	0.99350375
ENST00000300933	ENST00000392302	TPM4	chr19	16204563	+	NTRK1	chr1	156845871	+	0.010059488	0.98994046
ENST00000300933	ENST00000368196	TPM4	chr19	16204563	+	NTRK1	chr1	156845871	+	0.009582909	0.9904171
ENST00000300933	ENST00000524377	TPM4	chr19	16204563	+	NTRK1	chr1	156845871	+	0.010041977	0.989958
ENST00000300933	ENST00000358660	TPM4	chr19	16204563	+	NTRK1	chr1	156845871	+	0.009984542	0.99001545
ENST00000344824	ENST00000392302	TPM4	chr19	16204563	+	NTRK1	chr1	156844362	+	0.012606453	0.9873935
ENST00000344824	ENST00000368196	TPM4	chr19	16204563	+	NTRK1	chr1	156844362	+	0.012219594	0.98778045
ENST00000344824	ENST00000524377	TPM4	chr19	16204563	+	NTRK1	chr1	156844362	+	0.013045374	0.9869546
ENST00000344824	ENST00000358660	TPM4	chr19	16204563	+	NTRK1	chr1	156844362	+	0.012486731	0.98751324
ENST00000538887	ENST00000392302	TPM4	chr19	16204563	+	NTRK1	chr1	156844362	+	0.012536842	0.9874631
ENST00000538887	ENST00000368196	TPM4	chr19	16204563	+	NTRK1	chr1	156844362	+	0.012154347	0.9878456
ENST00000538887	ENST00000524377	TPM4	chr19	16204563	+	NTRK1	chr1	156844362	+	0.012998179	0.9870018
ENST00000538887	ENST00000358660	TPM4	chr19	16204563	+	NTRK1	chr1	156844362	+	0.01242334	0.9875766
ENST00000300933	ENST00000392302	TPM4	chr19	16204563	+	NTRK1	chr1	156844362	+	0.015559483	0.98444057
ENST00000300933	ENST00000368196	TPM4	chr19	16204563	+	NTRK1	chr1	156844362	+	0.014842508	0.9851575
ENST00000300933	ENST00000524377	TPM4	chr19	16204563	+	NTRK1	chr1	156844362	+	0.016557984	0.983442
ENST00000300933	ENST00000358660	TPM4	chr19	16204563	+	NTRK1	chr1	156844362	+	0.015467046	0.984533

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>93411_93411_1_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000300933_NTRK1_chr1_156844362_ENST00000358660_length(amino acids)=699AA_BP=298
MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK
IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE
KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLS
DKLKEAETRAEFAERTVAKLEKTIDDLEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPED
GLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK
EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAG
MVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQP

--------------------------------------------------------------

>93411_93411_2_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000300933_NTRK1_chr1_156844362_ENST00000368196_length(amino acids)=696AA_BP=298
MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK
IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE
KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLS
DKLKEAETRAEFAERTVAKLEKTIDDLEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPED
GLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEAS
ESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVY
LAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQ

--------------------------------------------------------------

>93411_93411_3_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000300933_NTRK1_chr1_156844362_ENST00000392302_length(amino acids)=696AA_BP=298
MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK
IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE
KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLS
DKLKEAETRAEFAERTVAKLEKTIDDLEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPED
GLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEAS
ESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVY
LAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQ

--------------------------------------------------------------

>93411_93411_4_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000300933_NTRK1_chr1_156844362_ENST00000524377_length(amino acids)=697AA_BP=298
MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK
IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE
KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLS
DKLKEAETRAEFAERTVAKLEKTIDDLEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPED
GLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEAS
ESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVY
LAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQ

--------------------------------------------------------------

>93411_93411_5_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000300933_NTRK1_chr1_156845311_ENST00000358660_length(amino acids)=646AA_BP=298
MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK
IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE
KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLS
DKLKEAETRAEFAERTVAKLEKTIDDLEGPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDI
VLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF
LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLP
IRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR

--------------------------------------------------------------

>93411_93411_6_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000300933_NTRK1_chr1_156845311_ENST00000368196_length(amino acids)=643AA_BP=298
MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK
IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE
KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLS
DKLKEAETRAEFAERTVAKLEKTIDDLEGPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLK
WELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRS
HGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRW
MPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQA

--------------------------------------------------------------

>93411_93411_7_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000300933_NTRK1_chr1_156845311_ENST00000392302_length(amino acids)=643AA_BP=298
MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK
IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE
KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLS
DKLKEAETRAEFAERTVAKLEKTIDDLEGPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLK
WELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRS
HGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRW
MPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQA

--------------------------------------------------------------

>93411_93411_8_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000300933_NTRK1_chr1_156845311_ENST00000524377_length(amino acids)=644AA_BP=298
MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK
IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE
KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLS
DKLKEAETRAEFAERTVAKLEKTIDDLEGPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLK
WELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRS
HGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRW
MPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQA

--------------------------------------------------------------

>93411_93411_9_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000300933_NTRK1_chr1_156845871_ENST00000358660_length(amino acids)=594AA_BP=298
MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK
IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE
KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLS
DKLKEAETRAEFAERTVAKLEKTIDDLEGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAE
LLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLA
TRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQ

--------------------------------------------------------------

>93411_93411_10_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000300933_NTRK1_chr1_156845871_ENST00000368196_length(amino acids)=594AA_BP=298
MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK
IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE
KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLS
DKLKEAETRAEFAERTVAKLEKTIDDLEGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAE
LLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLA
TRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQ

--------------------------------------------------------------

>93411_93411_11_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000300933_NTRK1_chr1_156845871_ENST00000392302_length(amino acids)=594AA_BP=298
MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK
IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE
KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLS
DKLKEAETRAEFAERTVAKLEKTIDDLEGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAE
LLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLA
TRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQ

--------------------------------------------------------------

>93411_93411_12_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000300933_NTRK1_chr1_156845871_ENST00000524377_length(amino acids)=595AA_BP=298
MWPAVPTSGPPPAVLTSAVRPGDLIAPTAAGPGGGERRGRPPRRQRLGGPGRGCAALAGAEPSRASAAARAPLRLRAMAGLNSLEAVKRK
IQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEE
KMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLS
DKLKEAETRAEFAERTVAKLEKTIDDLEGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAE
LLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLA
TRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQ

--------------------------------------------------------------

>93411_93411_13_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000344824_NTRK1_chr1_156844362_ENST00000358660_length(amino acids)=678AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEG
KGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQ
HQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV
GQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELER

--------------------------------------------------------------

>93411_93411_14_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000344824_NTRK1_chr1_156844362_ENST00000368196_length(amino acids)=675AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEG
KGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQH
IVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG
LVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRA

--------------------------------------------------------------

>93411_93411_15_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000344824_NTRK1_chr1_156844362_ENST00000392302_length(amino acids)=675AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEG
KGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQH
IVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG
LVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRA

--------------------------------------------------------------

>93411_93411_16_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000344824_NTRK1_chr1_156844362_ENST00000524377_length(amino acids)=676AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEG
KGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQH
IVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG
LVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRA

--------------------------------------------------------------

>93411_93411_17_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000344824_NTRK1_chr1_156845311_ENST00000358660_length(amino acids)=625AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEGPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHN
LLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGP
LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVW

--------------------------------------------------------------

>93411_93411_18_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000344824_NTRK1_chr1_156845311_ENST00000368196_length(amino acids)=622AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEGPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLP
EQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGL
GQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFG

--------------------------------------------------------------

>93411_93411_19_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000344824_NTRK1_chr1_156845311_ENST00000392302_length(amino acids)=622AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEGPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLP
EQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGL
GQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFG

--------------------------------------------------------------

>93411_93411_20_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000344824_NTRK1_chr1_156845311_ENST00000524377_length(amino acids)=623AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEGPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLP
EQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGL
GQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFG

--------------------------------------------------------------

>93411_93411_21_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000344824_NTRK1_chr1_156845871_ENST00000358660_length(amino acids)=573AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGR
PLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR
DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGC

--------------------------------------------------------------

>93411_93411_22_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000344824_NTRK1_chr1_156845871_ENST00000368196_length(amino acids)=573AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGR
PLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR
DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGC

--------------------------------------------------------------

>93411_93411_23_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000344824_NTRK1_chr1_156845871_ENST00000392302_length(amino acids)=573AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGR
PLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR
DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGC

--------------------------------------------------------------

>93411_93411_24_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000344824_NTRK1_chr1_156845871_ENST00000524377_length(amino acids)=574AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGR
PLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR
DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGC

--------------------------------------------------------------

>93411_93411_25_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000538887_NTRK1_chr1_156844362_ENST00000358660_length(amino acids)=678AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEG
KGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQ
HQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV
GQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELER

--------------------------------------------------------------

>93411_93411_26_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000538887_NTRK1_chr1_156844362_ENST00000368196_length(amino acids)=675AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEG
KGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQH
IVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG
LVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRA

--------------------------------------------------------------

>93411_93411_27_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000538887_NTRK1_chr1_156844362_ENST00000392302_length(amino acids)=675AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEG
KGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQH
IVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG
LVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRA

--------------------------------------------------------------

>93411_93411_28_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000538887_NTRK1_chr1_156844362_ENST00000524377_length(amino acids)=675AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEG
KGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQH
IVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG
LVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRA

--------------------------------------------------------------

>93411_93411_29_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000538887_NTRK1_chr1_156845311_ENST00000358660_length(amino acids)=625AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEGPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHN
LLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGP
LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVW

--------------------------------------------------------------

>93411_93411_30_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000538887_NTRK1_chr1_156845311_ENST00000368196_length(amino acids)=622AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEGPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLP
EQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGL
GQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFG

--------------------------------------------------------------

>93411_93411_31_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000538887_NTRK1_chr1_156845311_ENST00000392302_length(amino acids)=622AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEGPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLP
EQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGL
GQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFG

--------------------------------------------------------------

>93411_93411_32_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000538887_NTRK1_chr1_156845311_ENST00000524377_length(amino acids)=622AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEGPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLP
EQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGL
GQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFG

--------------------------------------------------------------

>93411_93411_33_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000538887_NTRK1_chr1_156845871_ENST00000358660_length(amino acids)=573AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGR
PLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR
DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGC

--------------------------------------------------------------

>93411_93411_34_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000538887_NTRK1_chr1_156845871_ENST00000368196_length(amino acids)=573AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGR
PLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR
DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGC

--------------------------------------------------------------

>93411_93411_35_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000538887_NTRK1_chr1_156845871_ENST00000392302_length(amino acids)=573AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGR
PLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR
DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGC

--------------------------------------------------------------

>93411_93411_36_TPM4-NTRK1_TPM4_chr19_16204563_ENST00000538887_NTRK1_chr1_156845871_ENST00000524377_length(amino acids)=573AA_BP=277
MPQPPQSPPRTPRPPRQRPAMEAIKKKMQMLKLDKENAIDRAEQAEADKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSEDLKDAQEK
LELTEKKASDAEGDVAALNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADR
KYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLE
KTIDDLEGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGR
PLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR
DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGC

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:16204563/chr1:156845311)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TPM4 P67936	NTRK1 P04629
FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432). {ECO:0000250\|UniProtKB:P09495, ECO:0000269\|PubMed:1836432}.	FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:22649032, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. {ECO:0000250\|UniProtKB:P35739, ECO:0000250\|UniProtKB:Q3UFB7, ECO:0000269\|PubMed:11244088, ECO:0000269\|PubMed:1281417, ECO:0000269\|PubMed:15488758, ECO:0000269\|PubMed:17196528, ECO:0000269\|PubMed:1849459, ECO:0000269\|PubMed:1850821, ECO:0000269\|PubMed:22649032, ECO:0000269\|PubMed:27445338, ECO:0000269\|PubMed:27676246, ECO:0000269\|PubMed:8155326, ECO:0000269\|PubMed:8325889}.; FUNCTION: [Isoform TrkA-III]: Resistant to NGF, it constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. {ECO:0000269\|PubMed:15488758}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TPM4

chr19:16204563

chr1:156844362

ENST00000344824

2_248

257.3333333333333

285.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM4

chr19:16204563

chr1:156844362

ENST00000538887

2_248

257.3333333333333

270.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM4

chr19:16204563

chr1:156845311

ENST00000344824

2_248

257.3333333333333

285.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM4

chr19:16204563

chr1:156845311

ENST00000538887

2_248

257.3333333333333

270.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM4

chr19:16204563

chr1:156845871

ENST00000344824

2_248

257.3333333333333

285.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM4

chr19:16204563

chr1:156845871

ENST00000538887

2_248

257.3333333333333

270.0

Coiled coil

Ontology_term=ECO:0000250

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000368196

510_781

392.3333333333333

791.0

Domain

Protein kinase

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000392302

510_781

362.3333333333333

761.0

Domain

Protein kinase

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000524377

510_781

398.3333333333333

797.0

Domain

Protein kinase

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000368196

510_781

445.3333333333333

791.0

Domain

Protein kinase

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000392302

510_781

415.3333333333333

761.0

Domain

Protein kinase

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000524377

510_781

451.3333333333333

797.0

Domain

Protein kinase

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000368196

510_781

494.3333333333333

791.0

Domain

Protein kinase

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000392302

510_781

464.3333333333333

761.0

Domain

Protein kinase

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000524377

510_781

500.3333333333333

797.0

Domain

Protein kinase

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000368196

537_541

392.3333333333333

791.0

Motif

DXXLL

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000368196

607_611

392.3333333333333

791.0

Motif

DXXLL

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000392302

537_541

362.3333333333333

761.0

Motif

DXXLL

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000392302

607_611

362.3333333333333

761.0

Motif

DXXLL

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000524377

537_541

398.3333333333333

797.0

Motif

DXXLL

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000524377

607_611

398.3333333333333

797.0

Motif

DXXLL

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000368196

537_541

445.3333333333333

791.0

Motif

DXXLL

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000368196

607_611

445.3333333333333

791.0

Motif

DXXLL

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000392302

537_541

415.3333333333333

761.0

Motif

DXXLL

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000392302

607_611

415.3333333333333

761.0

Motif

DXXLL

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000524377

537_541

451.3333333333333

797.0

Motif

DXXLL

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000524377

607_611

451.3333333333333

797.0

Motif

DXXLL

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000368196

537_541

494.3333333333333

791.0

Motif

DXXLL

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000368196

607_611

494.3333333333333

791.0

Motif

DXXLL

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000392302

537_541

464.3333333333333

761.0

Motif

DXXLL

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000392302

607_611

464.3333333333333

761.0

Motif

DXXLL

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000524377

537_541

500.3333333333333

797.0

Motif

DXXLL

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000524377

607_611

500.3333333333333

797.0

Motif

DXXLL

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000368196

516_524

392.3333333333333

791.0

Nucleotide binding

ATP

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000392302

516_524

362.3333333333333

761.0

Nucleotide binding

ATP

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000524377

516_524

398.3333333333333

797.0

Nucleotide binding

ATP

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000368196

516_524

445.3333333333333

791.0

Nucleotide binding

ATP

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000392302

516_524

415.3333333333333

761.0

Nucleotide binding

ATP

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000524377

516_524

451.3333333333333

797.0

Nucleotide binding

ATP

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000368196

516_524

494.3333333333333

791.0

Nucleotide binding

ATP

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000392302

516_524

464.3333333333333

761.0

Nucleotide binding

ATP

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000524377

516_524

500.3333333333333

797.0

Nucleotide binding

ATP

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000368196

440_796

392.3333333333333

791.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000392302

440_796

362.3333333333333

761.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000524377

440_796

398.3333333333333

797.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000392302

440_796

415.3333333333333

761.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000368196

424_439

392.3333333333333

791.0

Transmembrane

Helical

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000392302

424_439

362.3333333333333

761.0

Transmembrane

Helical

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000524377

424_439

398.3333333333333

797.0

Transmembrane

Helical

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000392302

424_439

415.3333333333333

761.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TPM4

chr19:16204563

chr1:156844362

ENST00000300933

2_248

221.33333333333334

249.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM4

chr19:16204563

chr1:156845311

ENST00000300933

2_248

221.33333333333334

249.0

Coiled coil

Ontology_term=ECO:0000250

Hgene

TPM4

chr19:16204563

chr1:156845871

ENST00000300933

2_248

221.33333333333334

249.0

Coiled coil

Ontology_term=ECO:0000250

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000368196

148_193

392.3333333333333

791.0

Domain

Note=LRRCT

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000368196

194_283

392.3333333333333

791.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000368196

299_365

392.3333333333333

791.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000392302

148_193

362.3333333333333

761.0

Domain

Note=LRRCT

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000392302

194_283

362.3333333333333

761.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000392302

299_365

362.3333333333333

761.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000524377

148_193

398.3333333333333

797.0

Domain

Note=LRRCT

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000524377

194_283

398.3333333333333

797.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000524377

299_365

398.3333333333333

797.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000368196

148_193

445.3333333333333

791.0

Domain

Note=LRRCT

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000368196

194_283

445.3333333333333

791.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000368196

299_365

445.3333333333333

791.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000392302

148_193

415.3333333333333

761.0

Domain

Note=LRRCT

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000392302

194_283

415.3333333333333

761.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000392302

299_365

415.3333333333333

761.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000524377

148_193

451.3333333333333

797.0

Domain

Note=LRRCT

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000524377

194_283

451.3333333333333

797.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000524377

299_365

451.3333333333333

797.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000368196

148_193

494.3333333333333

791.0

Domain

Note=LRRCT

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000368196

194_283

494.3333333333333

791.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000368196

299_365

494.3333333333333

791.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000392302

148_193

464.3333333333333

761.0

Domain

Note=LRRCT

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000392302

194_283

464.3333333333333

761.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000392302

299_365

464.3333333333333

761.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000524377

148_193

500.3333333333333

797.0

Domain

Note=LRRCT

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000524377

194_283

500.3333333333333

797.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000524377

299_365

500.3333333333333

797.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000368196

116_137

392.3333333333333

791.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000368196

90_113

392.3333333333333

791.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000392302

116_137

362.3333333333333

761.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000392302

90_113

362.3333333333333

761.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000524377

116_137

398.3333333333333

797.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000524377

90_113

398.3333333333333

797.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000368196

116_137

445.3333333333333

791.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000368196

90_113

445.3333333333333

791.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000392302

116_137

415.3333333333333

761.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000392302

90_113

415.3333333333333

761.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000524377

116_137

451.3333333333333

797.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000524377

90_113

451.3333333333333

797.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000368196

116_137

494.3333333333333

791.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000368196

90_113

494.3333333333333

791.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000392302

116_137

464.3333333333333

761.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000392302

90_113

464.3333333333333

761.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000524377

116_137

500.3333333333333

797.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000524377

90_113

500.3333333333333

797.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000368196

33_423

392.3333333333333

791.0

Topological domain

Extracellular

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000392302

33_423

362.3333333333333

761.0

Topological domain

Extracellular

Tgene

NTRK1

chr19:16204563

chr1:156844362

ENST00000524377

33_423

398.3333333333333

797.0

Topological domain

Extracellular

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000368196

33_423

445.3333333333333

791.0

Topological domain

Extracellular

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000368196

440_796

445.3333333333333

791.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000392302

33_423

415.3333333333333

761.0

Topological domain

Extracellular

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000524377

33_423

451.3333333333333

797.0

Topological domain

Extracellular

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000524377

440_796

451.3333333333333

797.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000368196

33_423

494.3333333333333

791.0

Topological domain

Extracellular

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000368196

440_796

494.3333333333333

791.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000392302

33_423

464.3333333333333

761.0

Topological domain

Extracellular

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000392302

440_796

464.3333333333333

761.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000524377

33_423

500.3333333333333

797.0

Topological domain

Extracellular

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000524377

440_796

500.3333333333333

797.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000368196

424_439

445.3333333333333

791.0

Transmembrane

Helical

Tgene

NTRK1

chr19:16204563

chr1:156845311

ENST00000524377

424_439

451.3333333333333

797.0

Transmembrane

Helical

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000368196

424_439

494.3333333333333

791.0

Transmembrane

Helical

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000392302

424_439

464.3333333333333

761.0

Transmembrane

Helical

Tgene

NTRK1

chr19:16204563

chr1:156845871

ENST00000524377

424_439

500.3333333333333

797.0

Transmembrane

Helical

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
NTRK1	ABL1, NGF, MATK, PLCG1, GRB2, CAV1, NTF3, SQSTM1, SH2B1, SHC1, SH2B2, ARHGAP32, FRS2, NTRK1, RAP1A, SHC3, GIPC1, RGS19, PTPN1, TRAF6, NEDD4, CBL, HSP90AA1, HSPA4, CDC37, NEDD4L, MYC, SGSM3, SORBS1, TNK2, SNX17, SNX27, GAREML, SOS2, PIK3CA, GAREM, PIK3C2B, ARHGEF40, PIK3R1, PIK3R2, SOS1, PIK3CB, PML, UBC, AMFR, CBLB, GAB1, EPN1, PIK3C2A, ANKRD13A, DOCK4, TRIO, LGR5, WRNIP1, RABEP1, PDGFRA, KANK2, RABGEF1, VAV2, TBC1D15, PTPN11, GAK, IRS2, PCDHGC3, EPS15, LRRN3, HUWE1, ACVR1B, MIB1, OFD1, PIBF1, ZNF497, TXN, CAT, FABP3, JUP, DSG1, TGM1, CFL1, LCN1, HIST2H4A, DSP, PFN1, LGALS3BP, HIST1H2BL, LTF, S100A9, IGLL5, TGM3, DSC1, LYZ, DCD, LEKR1, ENO2, PPIA, BTN1A1, XRCC5, XRCC6, HLA-A, GSTP1, ABCB7, PA2G4, PRDX1, HDGF, HSPA4L, TBC1D10B, HP1BP3, KIF26B, SYT4, RHOBTB3, NOTCH3, GAB2, ATAD3A, RBM15B, KCNH2, USP15, PDCD11, RBFOX2, RBM14, RNF31, ADNP, ZC3HAV1, MAP7D1, USP4, JAK1, PTPRS, PDGFRB, HIST1H1C, USP11, PPFIBP1, INTS6, VGF, ARHGEF11, SMPD4, SYNPO2, HNRNPM, SLC27A4, DDX41, EGFR, H1FX, ASAP1, HIST1H1B, RRBP1, EPHA2, KIDINS220, CPT1A, UNC5B, IGF1R, DDR2, AUP1, XPR1, RP9, MARK2, REPS1, EMD, SMARCA4, DDX21, DAB2IP, C7, MSTO1, CDC27, ZNF629, ASAP2, NCAPH2, SRBD1, ATAD3B, TCF12, PLEKHA6, INPPL1, PRPF4B, DPM1, SMARCA1, FIP1L1, DLGAP5, PLEKHH3, TRA2A, ACIN1, DDX10, TAX1BP1, SMARCA5, RABEP2, DDX5, MYO1C, SRSF10, DNAJA2, RET, TRA2B, MYEF2, PNPLA6, SLC12A2, TAF6L, RSL1D1, ARAP3, DDX18, ABL2, KHDRBS1, CERK, SRSF7, SPTLC2, PBXIP1, DNAJA1, IQGAP3, DDX31, ZC3H11A, PLRG1, CNP, FMR1, HIP1R, KIAA1429, CDC5L, ARAP1, ZNF316, SMARCC2, EML5, VANGL2, SLC25A1, UNC5C, SLC16A1, RFC1, ZKSCAN1, CHD1, PTK7, SMARCD2, AP3B1, YTHDC2, AKAP8L, RPL15, CTNND1, PHLDB1, ZNF574, DDX27, TOM1, RASA1, MORC2, MTCH2, IMMT, SMARCC1, ROR2, CAPN2, DNAJC11, SYT11, AP2A1, LBR, MEPCE, NCAPD3, CEP97, QKI, LRRC41, LPCAT2, EPS15L1, LAS1L, TMEM131, CWF19L2, NCAPG2, MAP4K5, CCP110, ARHGEF2, ITGAV, ZC3H18, CWC22, VIM, FAM171A1, TMEM132A, SRSF9, SOGA1, NKRF, RBL1, FMNL3, TOP1, PIGT, RBM15, GBAS, EDC3, WDR5, NOP2, GNL2, SLC25A11, RRP1B, FAM115A, INTS5, SLC25A5, AAK1, HERC5, CCNT1, FERMT2, CDC42BPA, MRPL28, UBAP2, WWP2, SEC24B, HNRNPU, GPD2, FXR2, DHX15, SLC25A22, SSR1, PLXNB2, PROX1, TEX10, USP19, FTSJ3, TMEM59, GTF3C2, PGAM5, CPSF1, KLHL22, TMX3, SIN3A, NOP58, PTCD3, RPRD2, DHX9, PICALM, FARP1, SLC25A6, ERLIN2, SMARCD1, RHOT1, ALDH1B1, SGPL1, USP9X, HNRNPF, KIAA1211, MAPK7, DDX17, GSE1, DVL3, MRPL44, DNAJB6, GTPBP4, HNRNPA0, PLXNA4, SFXN3, NAT10, DDX28, SNW1, MYO6, MRPL24, PRRT4, FAM98A, PURA, DHX29, C1QBP, TRIP4, TBK1, RBM28, ZNF609, POLRMT, PCDHB3, XRN1, HSD17B11, DKC1, DHX30, CDK13, SENP3, LPHN2, GPATCH4, NDUFA9, RASA4, MCCC1, DDX24, RPL14, RPS8, ATG2B, MYO1B, PTPN12, CEBPZ, ILVBL, RALY, KIF14, ZC3H7A, MOV10, MAP4K4, DHX57, RBMX, FXR1, MRPS35, SART1, MARK3, DECR1, CCDC88A, ANKLE2, PRPF31, LARP7, RPL10, PACS1, RPL13, FAM120A, SLC25A13, ADAR, CDK1, HNRNPR, CSNK1E, DLG1, LEMD3, NOL9, IFT122, NCLN, STK11IP, GATAD2B, CHERP, LARP4, MAP3K1, HNRNPUL2, PPIL2, ESYT2, MYH10, RPL8, UQCRC2, NDUFA10, HAX1, HELLS, MED14, RBM42, CHCHD3, RPL7, ABCD3, TUBGCP6, MRPS9, SNRNP200, IGF2BP3, LRCH3, MRPL3, RSBN1L, SAFB, TUBG1, ALDH16A1, ARHGEF12, EPB41L5, AP2A2, SRSF6, HLTF, PTPLAD1, TMPO, AGO2, POP1, RPS9, HDAC6, ILF3, VWA8, ABCB1, SCRIB, GTF3C5, YBX1, RBM4, PTPN9, PRPF8, BRD3, TRIM24, CLASP2, MADD, TCF4, MAP4K3, TSC2, DDX23, RPL7A, RRP12, PRKD2, TRMT1L, EDC4, CSTF3, RPS2, NDUFS2, RPL13A, PTPRR, ATP7A, EXD2, IK, HIP1, MATR3, IGSF3, PTPRF, SPATA5L1, EFTUD2, RPS3A, TUBGCP5, TTN, GIT1, PATL1, NUP160, PDE4B, SUN2, PTPN23, RPS6, DCP1A, CDC73, MEX3A, EIF2AK2, RPL3, PPP1R10, SRP72, ELAVL3, NOM1, RPL18, CEP170, THRAP3, MED17, MRPS7, DDX20, PDPR, SH3PXD2A, DBN1, DAP3, OAS3, STT3B, COPE, MED12, AP3D1, CAPRIN1, PHB2, U2SURP, BSG, TECR, FARSA, HSD17B12, RPL4, HNRNPUL1, PPFIA1, MRPS22, TBL3, GNL3, MTA2, CPSF2, ATP2B1, AP3B2, PPIP5K2, DDX56, ASCC3, FMNL2, SMCHD1, MYBBP1A, SRPK2, RHOT2, SRP68, PUM1, SLC25A3, SRPK1, RPL19, BEND3, SEC61A1, LSG1, NOC3L, TNKS1BP1, GTF3C3, TUBGCP3, PRPF40A, TRMT10C, URGCP, XRN2, MSH3, XRCC1, GEMIN4, DIS3L2, BCLAF1, SBF2, DHTKD1, ATXN2, ARID4B, TOR1AIP1, RPL29, NAA16, PRPF6, KIFAP3, TMEM33, WASF2, NACAD, LIG3, POLE, CKAP4, TCEB3, MTA1, GNA13, DHX38, PHF6, ELAVL4, DDX3X, CTR9, PRPF19, CAMSAP2, PRMT3, SH3PXD2B, SCAF8, MAGED1, ILF2, TONSL, PPP1R12A, SRSF5, KIAA0020, PTBP1, CAD, ACSL3, CHD1L, STAU1, MRPL38, DVL2, GNAI3, RPL10A, RPL6, MRPS5, CDK11B, MRPS34, PES1, ATP5C1, STXBP3, HNRNPLL, CHTF18, VPS39, SART3, COPA, PRPF3, UBE2O, ABCF2, HNRNPH3, EARS2, DHX40, ARHGEF7, EMC1, CASK, PTK2, SORT1, OGT, ATP12A, LMNB1, SLC4A7, PFKP, VDAC2, RBM25, ATL3, DHX36, TFIP11, EXOSC10, GTF3C1, SRSF1, PPP6C, TRAPPC9, RAD21, DNAJC13, ACOT1, ZC3H4, SRRM1, NDUFS3, DYRK1A, INTS1, SF3B2, EHHADH, MYO9B, ASCC2, WDR11, RPN1, EHD4, WDR91, SMARCAL1, NBAS, PI4KA, PAF1, EIF2B4, NUP107, EMC2, SYNE1, KLHL13, TBL1XR1, DNAJC10, SEC16A, METTL13, C7orf50, CDC42BPB, CLCN5, PGM3, DOCK7, ALYREF, POLR3A, TOP3A, WDR48, WDR81, DOCK1, CSNK2A2, CYC1, TLE3, THOC2, EIF2S3, MYO5A, SNX9, TARDBP, NAP1L4, CRKL, YTHDF2, PYGB, PABPC1, LTV1, PSMD4, KTN1, UBTF, WDR6, FUBP3, UBXN7, PHB, PDXP, CNOT3, TBL2, LLGL1, PLOD1, AHSA1, AAAS, ERGIC1, LARP4B, CYFIP1, DNM1, TARS2, ACSL1, ATXN1L, WDR59, SUCLA2, MLH1, CSNK2B, SYNCRIP, WDR36, FAM91A1, MTDH, UBE3C, CAPN1, BRIX1, DNAJB11, EDEM3, PLOD3, CLASP1, DPYSL3, MED16, NONO, EPM2AIP1, NT5DC2, ADRBK2, RPTOR, TELO2, MRPL37, PRKACB, ELMO1, TRAPPC8, ANAPC1, NIPSNAP1, EWSR1, PIK3R4, POLD1, IQGAP1, PRRC2A, COG1, ANKRD44, TFRC, DIEXF, FHOD1, SERPINH1, SPATA5, MED1, ABCF3, ZSWIM8, LMNA, HAT1, PABPC4, SMC4, HADH, RNGTT, TUBGCP2, ZNF598, SKIV2L2, GNB2L1, LARP1, DIP2B, BCR, IDH3B, LSM14A, FBL, NDUFS1, APPL2, USP39, SMC2, HCFC1, LANCL1, POLR2B, UPF2, CCBL2, MRPL15, MAGED2, AGK, GNPAT, AIMP1, GTF3C4, KDM1A, SCAMP3, RDH11, SRGAP2, CRNKL1, RFC5, PFKL, SPTBN1, PHOX2A, VDAC3, HNRNPA1, WDR26, DNM2, HAUS5, LCMT2, MCM7, CLINT1, UGDH, ACO1, TRIM46, PHKB, USP10, PCF11, YTHDF3, AARS2, FIGNL1, SFPQ, ATP5A1, NUP133, CPSF3, ANKRD28, PNN, C9orf64, ABCF1, ATL1, NAP1L1, HSPA9, MCCC2, FKBP5, CNOT1, TAF6, NEMF, UHRF1, SDHA, PELP1, HADHB, OAT, NEK9, AP3M1, PRKCA, LPCAT1, MRPL39, AFG3L2, WASF1, HNRNPL, RALGAPB, HK1, GBA, PLD3, CPSF7, HADHA, PDE12, DCX, LIMA1, HNRNPA2B1, POLR2A, MYH9, ZNF207, DDX55, ELP3, EIF2B5, MICAL1, TTI1, NES, HSDL1, GPSM1, PPM1F, C4orf27, SRRM2, OSBPL9, STAT3, IRF2BPL, KLC2, P3H1, STAT5B, UQCRC1, PCK2, CCAR2, TBC1D5, SACM1L, QARS, XPO4, CHD4, KIF2A, TACC3, NCL, BTAF1, RARS2, NCKAP1, EIF3D, RPS3, YME1L1, EIF4A3, HAUS6, HNRNPDL, MON2, G3BP2, WDHD1, CSNK1A1, SDAD1, RPS25, LSM14B, AP1M1, CCDC47, HNRNPK, DNMT1, NUP85, CUL5, TANC1, STAT1, COG5, STOML2, CDC45, OSBPL11, CIC, ABCD2, ARFGEF1, TROVE2, GBF1, SRPRB, UBE3A, GTPBP1, SCCPDH, RPS4X, PRPF4, ACTL6A, CCAR1, KIAA1033, TRAPPC12, HNRNPA3, FASTKD5, LYN, VPS18, PGRMC2, NUP214, AIFM1, TSG101, PPP6R3, OCRL, GANAB, IARS, SARS2, ATP2A2, EXOC1, NCAPH, TTC27, GNE, SRC, MIOS, ZCCHC8, GOLGA2, CARM1, ABCC1, PRMT5, LEO1, LMNB2, USP8, DARS, GYS1, APEH, ZYG11B, AKAP1, ELAVL1, MCM5, LRWD1, PSMC1, MOGS, TRIM28, EXOC6, LUC7L3, ANKFY1, NSUN2, HDAC2, G3BP1, QRICH1, INTS3, UBR1, XAB2, DYNC1LI1, TUFM, GAA, EXOC8, DHX8, LIMCH1, CLTC, SRPR, RNH1, ABI2, AQR, PREP, PPM1E, COG2, SEPT9, IDH2, MFN2, EXOC4, VPS33B, INTS4, GNB1, MSH6, HNRNPC, ERLIN1, EPRS, LRRC49, RPAP1, MCM3, PSMC4, PSMD3, GNL1, TRIP13, CUX1, PFAS, MAP1S, LRCH1, MRPL19, ABCD1, EIF3F, PDS5B, SMC3, KIF4A, FANCD2, IRF2BP1, SMC1A, RNF20, CLPX, NOC2L, DLAT, CTBP1, APPL1, NAA35, VPS45, PUM2, RELA, NUP210, RANBP9, DNAJC9, WRN, PRKAA1, AIMP2, VPS8, MAD1L1, MRE11A, ATP13A1, ATG7, CEP131, TRIM33, SLC25A10, HERC4, LRRFIP1, POLR1C, IPO9, GEMIN5, METAP2, SMG8, WASL, PPP1CB, SCFD1, RANBP3, RB1, CLTA, RNF40, SNRNP70, NCSTN, MGEA5, NARS, EIF4E, INPP4A, TFB2M, SEL1L, ARGLU1, PPP4R1, ANKRD17, TTK, RAD50, KIF2C, GOLGA3, TRAPPC11, GIGYF2, MSI2, CYFIP2, CDK5, HBS1L, IFT81, UFL1, PFKM, SMARCAD1, WDR35, PRIM2, NAMPT, PSMD2, MSH2, SOGA3, HEATR6, SFXN1, ARCN1, OGDH, FDPS, PSMC5, INSR, IRF2BP2, DDOST, ATXN2L, CSNK2A1, EIF2S2, MAP4, LTN1, COPB1, BRAT1, SMC6, SNRPN, RIC8A, SKIV2L, EIF4A1, KIF15, CLPTM1L, KPNA1, VPS16, VPS26B, RNPEP, RBM39, PMS1, FAM129B, RFC3, NUP155, RBM26, KIF21A, GAPVD1, C2CD5, WAPAL, RPS13, ARHGEF1, ACTR1A, KLC4, ISLR2, DCK, LRRC8A, STT3A, BOP1, RPN2, AFTPH, ORC3, FOXK1, CD2BP2, PDHA1, PPP6R1, PANK4, KIAA0196, WDR77, CHUK, DDX1, COLGALT1, VAPA, PPME1, CAMSAP1, RABL6, RTCB, SRRT, PIK3C3, NUMA1, STXBP1, OTUB1, UBAP2L, EXOC5, LRRC59, EXOC3, RQCD1, FLII, COPG2, USP5, XPOT, TIMM44, ATP1A1, SBF1, ARPC1B, PLK1, OSBPL8, BAG6, PPP6R2, FAM98B, VPS52, FADS2, EIF4G2, EIF4G3, HSPA8, POLR1B, PSMC6, SFSWAP, VPS33A, MCM10, AVL9, RINT1, PPIB, FBXL18, MFAP1, KIF13B, ATP2C1, ERCC2, CTTNBP2NL, WDR82, VARS, KPNA6, MIA3, HEATR1, SEC23B, AASDHPPT, POLR3B, ALDH18A1, PIKFYVE, MPP6, MRI1, CAPN7, RAB3GAP2, NCAPD2, UGGT1, IKBKAP, KDM3B, CLNS1A, FEN1, ECH1, AP2B1, HNRNPH1, RARS, AGPS, FANCI, PYCR2, EHD1, BUB3, KIF5B, SYMPK, PC, ACAA2, NDC80, PRRC2C, MTHFD1L, FASN, RANBP6, VPS11, NUP93, STRN, SCYL1, DDX19A, GTF2I, SEC23A, CTNNB1, STAM, VPRBP, VCL, PDHB, SEC24D, ERCC4, GRN, ACADM, HSPA6, ERCC6L, RPL5, ARHGAP17, DDX6, MAPK8IP3, TJP1, RIOK1, ERP29, PARG, NUP205, PALLD, COG4, TPP2, EPB41, VAC14, FUS, ZW10, KIF11, GET4, MCM6, EIF2S1, CSDE1, DHX16, GFM1, RABGAP1, TTC28, XPO1, EXOC2, DCTN1, ACBD3, RFC4, PARP1, COPG1, GPRIN1, EIF3C, CUL1, C14orf166, RTL1, STRIP1, MRPS2, PPP2R5D, EIF4G1, EXOSC4, MCM4, SEC63, WDR1, CUL4B, CRMP1, NSF, RNMT, BLVRA, UBE4A, PCBP1, MLLT4, RNF214, ARVCF, CKAP5, NUP188, SMCR8, CTNNA1, SYT1, PCM1, KNTC1, GFPT1, THYN1, SARM1, LPIN1, TIA1, NUP54, PKN1, SUMO4, DICER1, KIF3A, IPO8, CLIC4, PSMD14, GLG1, ABCE1, SMEK1, NCAPG, PPP5C, RTF1, IARS2, PDS5A, PHGDH, RPS6KA3, LONP1, ROCK1, CDK6, LARS, KPNA3, HNRNPAB, MCM2, PPP2R2A, HSP90AB2P, VCPIP1, PCBP2, RPA1, SEC24A, HECTD3, RCC2, DIS3, SMS, KHSRP, CLGN, GNAS, FOCAD, SEC23IP, ACOT7, HK2, CCDC6, MFN1, WDR7, CNN3, KIAA1524, RAB3GAP1, OXCT1, SBNO1, PRPSAP2, ACTR3, CTPS2, TMEM43, FAM21A, LRRC47, VAPB, SCYL2, STRN4, NAE1, SREK1, TFG, SF3A1, CDK2, GPKOW, GPHN, PDCD4, U2AF2, UNC45A, VPS35, NAA15, ASNS, TOP2B, ACO2, AGAP3, ROCK2, NUDT21, NPEPPS, ADD1, AP1G1, CPSF6, DNAJC2, RPS5, CTPS1, IDH1, SEC24C, KIF3B, ACTR2, CPD, EEF1D, SAMHD1, ETFB, DNM1L, LRPPRC, MCMBP, RBM12, OPA1, FARSB, UPF1, PCMT1, USO1, COG3, CLPTM1, TLK2, PRUNE, ASPSCR1, MARS, PYCR1, TCERG1, MED23, PITPNB, ARPC2, UBE4B, DBR1, ETFA, BICD1, KLC1, WDR70, PXDN, DPYSL4, USP7, CLUH, TBRG4, OGFR, SV2A, PDCD6IP, PDLIM5, PSMC2, TRAP1, DRG1, SMEK2, TCP1, TNPO2, CALD1, ARIH2, POR, FKBP3, DCTN2, NPM1, USP48, IPO13, NUP88, NNT, TAOK1, PPWD1, PSPC1, PABPN1, POLA1, MTR, BCCIP, RUVBL2, C16orf62, SORD, PPP2CA, STRN3, RUVBL1, PPP1CA, CACTIN, RPAP3, VPS51, TUBB3, PRKDC, HSPA5, CCDC132, MRPS27, RBBP4, CAPZA1, SLC4A1AP, THUMPD3, FAF1, CDK4, GSTO1, NCBP1, CAPZB, SNRPA, TXLNG, NELFE, MUT, DYNC1LI2, CTTN, DYNC1I2, TIMELESS, CBS, TTLL12, ESYT1, LAMB1, KARS, PPIL4, LRRC40, TXLNA, RAD23B, TBCE, ACAD9, THADA, GCN1L1, SLK, PNKP, ACLY, ATP6V0A1, VTA1, TXNDC5, OXSR1, ACACA, TNPO3, CCDC93, TIPRL, RAN, HOOK3, PSME4, YWHAQ, PPM1G, PSMC3, SCARB2, EXOC7, DFNA5, TRMT6, CPNE3, SLC3A2, G6PD, EIF2B1, SF3B1, EXOC6B, HGS, DYNC1H1, DNAJC7, CANX, TSR1, TTC37, DARS2, ZPR1, SERBP1, HSP90AB1, TBCB, UCHL5, IMPDH2, PUF60, RANGAP1, PDXDC1, YWHAH, LARS2, ZC3H15, GMPS, YWHAG, SUPV3L1, SPAG9, IMPDH1, HSD17B10, GTF2F1, EXOSC9, CUL3, ARHGAP35, TUBB4B, EIF5B, KIF5C, PDIA6, LDHA, ATL2, SNX1, SF3B3, SRM, MAP2, DIAPH1, DBH, NHLRC2, ELP2, GRPEL1, TWF1, WBP11, ERP44, SERPINB6, VCP, HSPH1, CMTR1, KIF1A, USP47, EML4, PRMT1, ATP6V1B2, GPS1, CAND1, CLPB, PCNA, RPLP0, CORO7, TUBB, ANXA2, API5, SUPT16H, RUFY1, KIAA1279, PDIA3, ACTA1, SF3A3, DCTN4, CUL2, WARS, PGM2, NELFB, XPO5, UGP2, HSP90B1, GSR, SHMT2, IPO11, EIF3E, RDX, DNAJB1, KIAA1598, AARS, EFTUD1, HEATR5B, ENAH, TNPO1, LIG1, NRD1, DLD, STRA6, PAFAH1B1, NT5C2, SSRP1, NTRK3, HDGFRP2, EIF3G, CSE1L, ACAT1, TBCD, NAA10, MTHFD1, RALA, EIF3A, PRPS1, ISOC1, IPO7, HNRNPD, GAPDH, U2AF1, SUPT5H, PSMD8, RPS6KA1, NUF2, GDAP1, VPS26A, TUBB2B, CDH2, TMOD1, CBR1, HDLBP, CS, HSPD1, LMAN1, EIF3B, DDB1, PSMD1, DPYSL2, STRAP, RTN4, FLNA, AHCY, HSD17B4, GOLIM4, SPTAN1, IPO4, PKM, EIF3I, SF1, BZW2, XPO7, ACADVL, STAG2, DPP9, RECQL, GDI1, GARS, MMS19, EIF2A, IPO5, TCOF1, RAB5C, SAP30BP, VDAC1, TUBA1A, SEPT2, DBNL, PLAA, TOMM70A, NOMO1, ISYNA1, CTNNA2, EEF1B2, PAK4, NELFCD, GSPT1, KPNB1, MAP1A, COPS4, YWHAZ, KPNA2, EIF4B, PLS3, COPS3, HSPBP1, AP1B1, NASP, DDX39A, LUC7L2, APMAP, SEC31A, SRSF2, TXNRD1, ATP1A3, RRM2, COG7, FSD1, PRDX4, DCPS, NCAM1, NUDCD1, NAA25, RPL9, NPLOC4, YWHAB, ATP1B1, LSS, DNAAF5, METTL16, COPS6, XPNPEP1, ELAC2, PUS7, CCT3, SFN, AGL, PAPOLA, SRSF11, ALDH2, PSME2, CKMT1B, LDHB, PSMA7, RAB11A, PPP2R1A, GNAO1, LUC7L, COPS5, IMPA1, RRM1, PPID, DPP3, KIAA0368, SLC1A5, YARS, NUP50, TPM4, ITGB1, SARS, SEZ6L2, GTF2F2, GART, ALDOC, PSMD11, EIF6, DFFA, RAP1GDS1, NELFA, CARS, CCT4, P4HB, FSCN1, PSMD13, PSMA5, CCT5, PAPSS1, OSBP, SAE1, ATP6V1A, LMAN2, YWHAE, SRP54, IDE, SNX2, RPSA, BZW1, SND1, UBQLN1, MAPK1, CALR, MARCKSL1, SUGT1, TBC1D4, GLRX3, LETM1, HMGB1, EIF3H, SLC9A3R1, DDX42, LAP3, PRKCSH, EEF2, PSMD6, BCAP31, ANXA11, ACTN1, CCT6A, PSMA4, ANXA5, CCT7, EIF3L, FUBP1, SSB, PGM1, MAPRE1, UBA2, AMPD2, PPAT, CLIC1, CCT2, ECHS1, LTA4H, USP14, CCT8, ANK2, PDIA4, TPR, NRCAM, MAT2A, HTATSF1, THOP1, RANBP1, RSRC2, NMT1, AK2, EEF1G, TPM3, PSMA3, EIF4H, GLUD1, CAP1, TKT, ATP5B, TXNL1, STIP1, HMGB2, GGH, HSPB1, CALU, RPL17, PSMA1, RSRC1, ST13, PRDX6, EIF3J, PNPT1, APEX1, TARS, MARCKS, PSMA6, EEF1A1, COPB2, NUDT5, HSPA1A, ERO1L, ME2, RPH3A, ESD, EIF5, ADSL, RUFY3, DPYSL5, ANXA6, NUDC, NANS, GOT2, GLDC, PSAT1, SET, PAK2, UBA6, UCHL1, L1CAM, PGLS, MAP1B, CCDC124, EIF3M, VAT1, PAFAH1B3, ALDOA, IRGQ, UBQLN2, NACA, OLA1, ACTN4, ARHGDIA, PSMD7, CACYBP, PSMA2, CPNE1, MDH2, PGAM1, DDX46, ACAT2, ALCAM, HARS, CKB, FKBP4, ASNA1, GPI, INA, HYOU1, CHGA, MDH1, EZR, ANP32A, UBA1, ARG1, ANP32B, PAICS, ATIC, TPI1, PPA1, TALDO1, PGK1, DDX39B, TLN1, AKR1B1, ENO1, NGFR, TPTE, GGA1, GGA2, GGA3, USP36, NDFIP1, SOCS2, CDK12, EPHB4, NDUFA4L2, AKT1, SLC5A5, DOT1L, AKT2, SHC4, TRAF4, PTPN6, ERBB2, EGR1, HIPK2, POU4F2,
TPM4	TCERG1, TRIP6, PACSIN1, ARRB1, SP1, CDK2, AKT1, TPM3, TPM2, TPM1, SRXN1, HNRNPK, DBN1, ZYX, PCMT1, G3BP1, PSMD2, PSMA6, CDH2, SULT1A1, SERPINH1, ILF3, ILF2, TELO2, MYH9, PSMD1, SNRNP70, TXN2, SRSF2, PRKCDBP, CORO1C, TPM3P4, DCTN2, PSMC2, ATF2, PAN2, HDAC8, PARK2, CAP1, FASN, KIAA1598, SIRT1, TP53, LNX1, PYCARD, EGFR, ACTN1, ACTN2, COX5A, OSTF1, ACTN4, ATP1A1, ATP5F1, CENPE, CKB, COX4I1, MYH7B, NDUFB10, PSMA1, TBCD, NTRK1, ADD1, CAPZA2, FLNA, PPP1CB, PPP1CC, IQGAP1, SLC33A1, PDLIM7, MAPRE1, ANLN, MYO19, MYO18A, CFAP97, Actb, Mapre1, Flot1, Myh9, Myo1c, Rab5c, Tpm1, Dctn3, Uso1, Anapc13, Calml3, 2510003E04Rik, Myh10, Tbck, Mast3, MCM2, SMURF1, ZNF131, DLST, UBE2A, CFTR, TMPO, PTPLA, PPP6C, PPM1D, PTP4A3, PTPN2, CDC25C, PTPRCAP, DUSP7, PPTC7, DUSP19, PPM1M, ILKAP, DUSP21, PHPT1, DUSP12, PPP1R3C, EFTUD2, PIH1D1, TNF, NOD2, RNF181, RNF144A, CDK9, RAB9A, HK1, METTL14, WTAP, ATG16L1, ESR2, DISC1, USP14, APEX1, DYRK1A, SCARB2, VMP1, AKT3, ATF3, PICK1, SNAPIN, JRK, CUL7, PLEKHA4, SRC, UNK, CIT, AURKB, CHMP4C, ECT2, KIF20A, PRNP, MFN2, OPA1, HNRNPH1, nsp13ab, NPC1, UCHL1, COPS5, DANCR, RIN3, TRIM24, BAG5, AR, ISG15, TMOD1, TRIM37, NAA40, MRPL50, LANCL2, ALAD, BTF3, TRIM26, EP300, CTSB, CTSS, DPP4, E, ORF8, TMPRSS2, TOP3B, CTSL, FURIN, IFITM1, IFITM3, CLEC4D, CLEC4E, nsp4, nsp6, nsp8, ORF10, S, FGD5, CCNF, PDE4B, FOS, ELK3, GATA4, IRF8, KLF10, KLF12, KLF3, KLF6, VSX1, ZIC3, MYC, NKX2-5, SOX5, STAT5B, TEAD1, TLX1,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TPM4
NTRK1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	NTRK1	chr19:16204563	chr1:156845871	ENST00000368196		10	16	469_490	494.3333333333333	791.0	SQSTM1
Tgene	NTRK1	chr19:16204563	chr1:156845871	ENST00000524377		11	17	469_490	500.3333333333333	797.0	SQSTM1

Top

Related Drugs to TPM4-NTRK1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to TPM4-NTRK1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TPM4	C0001787	Osteoporosis, Age-Related	1	CTD_human
Hgene	TPM4	C0003949	Asbestosis	1	CTD_human
Hgene	TPM4	C0005818	Blood Platelet Disorders	1	GENOMICS_ENGLAND
Hgene	TPM4	C0014859	Esophageal Neoplasms	1	CTD_human
Hgene	TPM4	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Hgene	TPM4	C0027627	Neoplasm Metastasis	1	CTD_human
Hgene	TPM4	C0029456	Osteoporosis	1	CTD_human
Hgene	TPM4	C0029459	Osteoporosis, Senile	1	CTD_human
Hgene	TPM4	C0032927	Precancerous Conditions	1	CTD_human
Hgene	TPM4	C0043094	Weight Gain	1	CTD_human
Hgene	TPM4	C0282313	Condition, Preneoplastic	1	CTD_human
Hgene	TPM4	C0334121	Inflammatory Myofibroblastic Tumor	1	ORPHANET
Hgene	TPM4	C0546837	Malignant neoplasm of esophagus	1	CTD_human
Hgene	TPM4	C0751406	Post-Traumatic Osteoporosis	1	CTD_human
Hgene	TPM4	C0948089	Acute Coronary Syndrome	1	CTD_human
Hgene	TPM4	C2751260	Macrothrombocytopenia	1	GENOMICS_ENGLAND
Hgene	TPM4	C2930617	Pulmonary Fibrosis - from Asbestos Exposure	1	CTD_human
Hgene	TPM4	C4304021	Autosomal dominant macrothrombocytopenia	1	ORPHANET
Tgene	NTRK1	C0020074	HSAN Type IV	17	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	NTRK1	C0238463	Papillary thyroid carcinoma	3	ORPHANET
Tgene	NTRK1	C0002768	Congenital Pain Insensitivity	1	ORPHANET
Tgene	NTRK1	C0005586	Bipolar Disorder	1	CTD_human
Tgene	NTRK1	C0005587	Depression, Bipolar	1	CTD_human
Tgene	NTRK1	C0017638	Glioma	1	CTD_human
Tgene	NTRK1	C0020075	Hereditary Sensory Autonomic Neuropathy, Type 5	1	CTD_human;ORPHANET
Tgene	NTRK1	C0024713	Manic Disorder	1	CTD_human
Tgene	NTRK1	C0027796	Neuralgia	1	CTD_human
Tgene	NTRK1	C0027819	Neuroblastoma	1	CTD_human
Tgene	NTRK1	C0033958	Psychosis, Brief Reactive	1	CTD_human
Tgene	NTRK1	C0033975	Psychotic Disorders	1	CTD_human
Tgene	NTRK1	C0036337	Schizoaffective Disorder	1	CTD_human
Tgene	NTRK1	C0036341	Schizophrenia	1	CTD_human
Tgene	NTRK1	C0036358	Schizophreniform Disorders	1	CTD_human
Tgene	NTRK1	C0038870	Neuralgia, Supraorbital	1	CTD_human
Tgene	NTRK1	C0042656	Neuralgia, Vidian	1	CTD_human
Tgene	NTRK1	C0234247	Neuralgia, Atypical	1	CTD_human
Tgene	NTRK1	C0234249	Neuralgia, Stump	1	CTD_human
Tgene	NTRK1	C0259783	mixed gliomas	1	CTD_human
Tgene	NTRK1	C0273115	Lung Injury	1	CTD_human
Tgene	NTRK1	C0338831	Manic	1	CTD_human
Tgene	NTRK1	C0423711	Neuralgia, Perineal	1	CTD_human
Tgene	NTRK1	C0423712	Neuralgia, Iliohypogastric Nerve	1	CTD_human
Tgene	NTRK1	C0555198	Malignant Glioma	1	CTD_human
Tgene	NTRK1	C0598589	Inherited neuropathies	1	GENOMICS_ENGLAND
Tgene	NTRK1	C0751371	Neuralgia, Ilioinguinal	1	CTD_human
Tgene	NTRK1	C0751372	Nerve Pain	1	CTD_human
Tgene	NTRK1	C0751373	Paroxysmal Nerve Pain	1	CTD_human
Tgene	NTRK1	C0752347	Lewy Body Disease	1	CTD_human
Tgene	NTRK1	C1833921	Familial medullary thyroid carcinoma	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	NTRK1	C2350344	Chronic Lung Injury	1	CTD_human