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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:BCL2L13-CUX2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: BCL2L13-CUX2
FusionPDB ID: 9352
FusionGDB2.0 ID: 9352
HgeneTgene
Gene symbol

BCL2L13

CUX2

Gene ID

23786

23316

Gene nameBCL2 like 13cut like homeobox 2
SynonymsBCL-RAMBO|Bcl2-L-13|MIL1CDP2|CUTL2|EIEE67
Cytomap

22q11.21

12q24.11-q24.12

Type of geneprotein-codingprotein-coding
Descriptionbcl-2-like protein 13BCL2-like 13 (apoptosis facilitator)homeobox protein cut-like 2homeobox protein cux-2
Modification date2020031320200313
UniProtAcc

Q9BXK5

O14529

Ensembl transtripts involved in fusion geneENST idsENST00000317582, ENST00000355028, 
ENST00000399782, ENST00000418951, 
ENST00000493680, ENST00000538149, 
ENST00000337612, ENST00000543133, 
ENST00000485631, 		ENST00000551604, 
ENST00000261726, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 18 X 10=30607 X 7 X 5=245
# samples 238
** MAII scorelog2(23/3060*10)=-3.73382588663564
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/245*10)=-1.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: BCL2L13 [Title/Abstract] AND CUX2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)BCL2L13(18138598)-CUX2(111772245), # samples:3
Anticipated loss of major functional domain due to fusion event.BCL2L13-CUX2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BCL2L13-CUX2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BCL2L13-CUX2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BCL2L13-CUX2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BCL2L13-CUX2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
BCL2L13-CUX2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCUX2

GO:0000122

negative regulation of transcription by RNA polymerase II

15656993


check buttonFusion gene breakpoints across BCL2L13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CUX2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-T2-A6X0-01ABCL2L13chr22

18138598

-CUX2chr12

111772245

+
ChimerDB4HNSCTCGA-T2-A6X0-01ABCL2L13chr22

18138598

+CUX2chr12

111772245

+
ChimerDB4HNSCTCGA-T2-A6X0BCL2L13chr22

18138598

+CUX2chr12

111772244

+
ChimerDB4HNSCTCGA-T2-A6X0BCL2L13chr22

18138598

+CUX2chr12

111772245

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000399782BCL2L13chr2218138598+ENST00000261726CUX2chr12111772245+46248607392394551
ENST00000317582BCL2L13chr2218138598+ENST00000261726CUX2chr12111772245+42324683472002551
ENST00000493680BCL2L13chr2218138598+ENST00000261726CUX2chr12111772245+40502861651820551
ENST00000355028BCL2L13chr2218138598+ENST00000261726CUX2chr12111772245+40112471261781551
ENST00000418951BCL2L13chr2218138598+ENST00000261726CUX2chr12111772245+388512101655551
ENST00000399782BCL2L13chr2218138598+ENST00000261726CUX2chr12111772244+46248607392394551
ENST00000317582BCL2L13chr2218138598+ENST00000261726CUX2chr12111772244+42324683472002551
ENST00000493680BCL2L13chr2218138598+ENST00000261726CUX2chr12111772244+40502861651820551
ENST00000355028BCL2L13chr2218138598+ENST00000261726CUX2chr12111772244+40112471261781551
ENST00000418951BCL2L13chr2218138598+ENST00000261726CUX2chr12111772244+388512101655551

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000399782ENST00000261726BCL2L13chr2218138598+CUX2chr12111772245+0.0028612570.99713874
ENST00000317582ENST00000261726BCL2L13chr2218138598+CUX2chr12111772245+0.0038130740.9961869
ENST00000493680ENST00000261726BCL2L13chr2218138598+CUX2chr12111772245+0.004045990.99595404
ENST00000355028ENST00000261726BCL2L13chr2218138598+CUX2chr12111772245+0.0039022390.9960977
ENST00000418951ENST00000261726BCL2L13chr2218138598+CUX2chr12111772245+0.0038040530.9961959
ENST00000399782ENST00000261726BCL2L13chr2218138598+CUX2chr12111772244+0.0028612570.99713874
ENST00000317582ENST00000261726BCL2L13chr2218138598+CUX2chr12111772244+0.0038130740.9961869
ENST00000493680ENST00000261726BCL2L13chr2218138598+CUX2chr12111772244+0.004045990.99595404
ENST00000355028ENST00000261726BCL2L13chr2218138598+CUX2chr12111772244+0.0039022390.9960977
ENST00000418951ENST00000261726BCL2L13chr2218138598+CUX2chr12111772244+0.0038040530.9961959

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>9352_9352_1_BCL2L13-CUX2_BCL2L13_chr22_18138598_ENST00000317582_CUX2_chr12_111772244_ENST00000261726_length(amino acids)=551AA_BP=38
MASSSTVPLGFHYETKYVVLSYLGLLSQEKLQEQHLSSPQASPTEPRSSPSPPPSPTEPEKSSQEPLSLSLESSKENQQPEGRSSSSLSG
KMYSGSQAPGGIQEIVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLNDPHN
VEKLRDMKKLEKKAYLKRRYGLISTGSDSESPATRSECPSPCLQPQDLSLLQIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQL
NLKTNTVINWFHNYRSRMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKELELQEGPEENSTPLTTQDKAQ
VRIKQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPPGNDGLPKVAPGPLLPGGSTPDCPSLHPQQESEAGERLHPDPLSFKSASE
SSRCSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISPSPPGAPPAKVPSASPTADMAGALHPSAKVNPNLQRRHEKMANLNNIIYRVERA

--------------------------------------------------------------

>9352_9352_2_BCL2L13-CUX2_BCL2L13_chr22_18138598_ENST00000317582_CUX2_chr12_111772245_ENST00000261726_length(amino acids)=551AA_BP=38
MASSSTVPLGFHYETKYVVLSYLGLLSQEKLQEQHLSSPQASPTEPRSSPSPPPSPTEPEKSSQEPLSLSLESSKENQQPEGRSSSSLSG
KMYSGSQAPGGIQEIVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLNDPHN
VEKLRDMKKLEKKAYLKRRYGLISTGSDSESPATRSECPSPCLQPQDLSLLQIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQL
NLKTNTVINWFHNYRSRMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKELELQEGPEENSTPLTTQDKAQ
VRIKQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPPGNDGLPKVAPGPLLPGGSTPDCPSLHPQQESEAGERLHPDPLSFKSASE
SSRCSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISPSPPGAPPAKVPSASPTADMAGALHPSAKVNPNLQRRHEKMANLNNIIYRVERA

--------------------------------------------------------------

>9352_9352_3_BCL2L13-CUX2_BCL2L13_chr22_18138598_ENST00000355028_CUX2_chr12_111772244_ENST00000261726_length(amino acids)=551AA_BP=38
MASSSTVPLGFHYETKYVVLSYLGLLSQEKLQEQHLSSPQASPTEPRSSPSPPPSPTEPEKSSQEPLSLSLESSKENQQPEGRSSSSLSG
KMYSGSQAPGGIQEIVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLNDPHN
VEKLRDMKKLEKKAYLKRRYGLISTGSDSESPATRSECPSPCLQPQDLSLLQIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQL
NLKTNTVINWFHNYRSRMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKELELQEGPEENSTPLTTQDKAQ
VRIKQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPPGNDGLPKVAPGPLLPGGSTPDCPSLHPQQESEAGERLHPDPLSFKSASE
SSRCSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISPSPPGAPPAKVPSASPTADMAGALHPSAKVNPNLQRRHEKMANLNNIIYRVERA

--------------------------------------------------------------

>9352_9352_4_BCL2L13-CUX2_BCL2L13_chr22_18138598_ENST00000355028_CUX2_chr12_111772245_ENST00000261726_length(amino acids)=551AA_BP=38
MASSSTVPLGFHYETKYVVLSYLGLLSQEKLQEQHLSSPQASPTEPRSSPSPPPSPTEPEKSSQEPLSLSLESSKENQQPEGRSSSSLSG
KMYSGSQAPGGIQEIVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLNDPHN
VEKLRDMKKLEKKAYLKRRYGLISTGSDSESPATRSECPSPCLQPQDLSLLQIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQL
NLKTNTVINWFHNYRSRMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKELELQEGPEENSTPLTTQDKAQ
VRIKQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPPGNDGLPKVAPGPLLPGGSTPDCPSLHPQQESEAGERLHPDPLSFKSASE
SSRCSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISPSPPGAPPAKVPSASPTADMAGALHPSAKVNPNLQRRHEKMANLNNIIYRVERA

--------------------------------------------------------------

>9352_9352_5_BCL2L13-CUX2_BCL2L13_chr22_18138598_ENST00000399782_CUX2_chr12_111772244_ENST00000261726_length(amino acids)=551AA_BP=38
MASSSTVPLGFHYETKYVVLSYLGLLSQEKLQEQHLSSPQASPTEPRSSPSPPPSPTEPEKSSQEPLSLSLESSKENQQPEGRSSSSLSG
KMYSGSQAPGGIQEIVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLNDPHN
VEKLRDMKKLEKKAYLKRRYGLISTGSDSESPATRSECPSPCLQPQDLSLLQIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQL
NLKTNTVINWFHNYRSRMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKELELQEGPEENSTPLTTQDKAQ
VRIKQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPPGNDGLPKVAPGPLLPGGSTPDCPSLHPQQESEAGERLHPDPLSFKSASE
SSRCSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISPSPPGAPPAKVPSASPTADMAGALHPSAKVNPNLQRRHEKMANLNNIIYRVERA

--------------------------------------------------------------

>9352_9352_6_BCL2L13-CUX2_BCL2L13_chr22_18138598_ENST00000399782_CUX2_chr12_111772245_ENST00000261726_length(amino acids)=551AA_BP=38
MASSSTVPLGFHYETKYVVLSYLGLLSQEKLQEQHLSSPQASPTEPRSSPSPPPSPTEPEKSSQEPLSLSLESSKENQQPEGRSSSSLSG
KMYSGSQAPGGIQEIVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLNDPHN
VEKLRDMKKLEKKAYLKRRYGLISTGSDSESPATRSECPSPCLQPQDLSLLQIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQL
NLKTNTVINWFHNYRSRMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKELELQEGPEENSTPLTTQDKAQ
VRIKQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPPGNDGLPKVAPGPLLPGGSTPDCPSLHPQQESEAGERLHPDPLSFKSASE
SSRCSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISPSPPGAPPAKVPSASPTADMAGALHPSAKVNPNLQRRHEKMANLNNIIYRVERA

--------------------------------------------------------------

>9352_9352_7_BCL2L13-CUX2_BCL2L13_chr22_18138598_ENST00000418951_CUX2_chr12_111772244_ENST00000261726_length(amino acids)=551AA_BP=38
MASSSTVPLGFHYETKYVVLSYLGLLSQEKLQEQHLSSPQASPTEPRSSPSPPPSPTEPEKSSQEPLSLSLESSKENQQPEGRSSSSLSG
KMYSGSQAPGGIQEIVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLNDPHN
VEKLRDMKKLEKKAYLKRRYGLISTGSDSESPATRSECPSPCLQPQDLSLLQIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQL
NLKTNTVINWFHNYRSRMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKELELQEGPEENSTPLTTQDKAQ
VRIKQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPPGNDGLPKVAPGPLLPGGSTPDCPSLHPQQESEAGERLHPDPLSFKSASE
SSRCSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISPSPPGAPPAKVPSASPTADMAGALHPSAKVNPNLQRRHEKMANLNNIIYRVERA

--------------------------------------------------------------

>9352_9352_8_BCL2L13-CUX2_BCL2L13_chr22_18138598_ENST00000418951_CUX2_chr12_111772245_ENST00000261726_length(amino acids)=551AA_BP=38
MASSSTVPLGFHYETKYVVLSYLGLLSQEKLQEQHLSSPQASPTEPRSSPSPPPSPTEPEKSSQEPLSLSLESSKENQQPEGRSSSSLSG
KMYSGSQAPGGIQEIVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLNDPHN
VEKLRDMKKLEKKAYLKRRYGLISTGSDSESPATRSECPSPCLQPQDLSLLQIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQL
NLKTNTVINWFHNYRSRMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKELELQEGPEENSTPLTTQDKAQ
VRIKQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPPGNDGLPKVAPGPLLPGGSTPDCPSLHPQQESEAGERLHPDPLSFKSASE
SSRCSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISPSPPGAPPAKVPSASPTADMAGALHPSAKVNPNLQRRHEKMANLNNIIYRVERA

--------------------------------------------------------------

>9352_9352_9_BCL2L13-CUX2_BCL2L13_chr22_18138598_ENST00000493680_CUX2_chr12_111772244_ENST00000261726_length(amino acids)=551AA_BP=38
MASSSTVPLGFHYETKYVVLSYLGLLSQEKLQEQHLSSPQASPTEPRSSPSPPPSPTEPEKSSQEPLSLSLESSKENQQPEGRSSSSLSG
KMYSGSQAPGGIQEIVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLNDPHN
VEKLRDMKKLEKKAYLKRRYGLISTGSDSESPATRSECPSPCLQPQDLSLLQIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQL
NLKTNTVINWFHNYRSRMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKELELQEGPEENSTPLTTQDKAQ
VRIKQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPPGNDGLPKVAPGPLLPGGSTPDCPSLHPQQESEAGERLHPDPLSFKSASE
SSRCSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISPSPPGAPPAKVPSASPTADMAGALHPSAKVNPNLQRRHEKMANLNNIIYRVERA

--------------------------------------------------------------

>9352_9352_10_BCL2L13-CUX2_BCL2L13_chr22_18138598_ENST00000493680_CUX2_chr12_111772245_ENST00000261726_length(amino acids)=551AA_BP=38
MASSSTVPLGFHYETKYVVLSYLGLLSQEKLQEQHLSSPQASPTEPRSSPSPPPSPTEPEKSSQEPLSLSLESSKENQQPEGRSSSSLSG
KMYSGSQAPGGIQEIVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLNDPHN
VEKLRDMKKLEKKAYLKRRYGLISTGSDSESPATRSECPSPCLQPQDLSLLQIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQL
NLKTNTVINWFHNYRSRMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKELELQEGPEENSTPLTTQDKAQ
VRIKQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPPGNDGLPKVAPGPLLPGGSTPDCPSLHPQQESEAGERLHPDPLSFKSASE
SSRCSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISPSPPGAPPAKVPSASPTADMAGALHPSAKVNPNLQRRHEKMANLNNIIYRVERA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:18138598/chr12:111772245)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCL2L13

Q9BXK5

CUX2

O14529

FUNCTION: May promote the activation of caspase-3 and apoptosis.FUNCTION: Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner. {ECO:0000250|UniProtKB:P70298}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000317582+2714_3040.333333333333336486.0MotifNote=BH4
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000399782+3714_3040.333333333333336202.0MotifNote=BH4
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000493680+2614_3040.333333333333336202.0MotifNote=BH4
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000317582+2714_3040.333333333333336486.0MotifNote=BH4
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000399782+3714_3040.333333333333336202.0MotifNote=BH4
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000493680+2614_3040.333333333333336202.0MotifNote=BH4
TgeneCUX2chr22:18138598chr12:111772244ENST0000026172617221327_1437975.33333333333341487.0Compositional biasNote=Pro-rich
TgeneCUX2chr22:18138598chr12:111772245ENST0000026172617221327_1437975.33333333333341487.0Compositional biasNote=Pro-rich
TgeneCUX2chr22:18138598chr12:111772244ENST0000026172617221038_1125975.33333333333341487.0DNA bindingCUT 3
TgeneCUX2chr22:18138598chr12:111772244ENST0000026172617221168_1227975.33333333333341487.0DNA bindingHomeobox
TgeneCUX2chr22:18138598chr12:111772245ENST0000026172617221038_1125975.33333333333341487.0DNA bindingCUT 3
TgeneCUX2chr22:18138598chr12:111772245ENST0000026172617221168_1227975.33333333333341487.0DNA bindingHomeobox

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000317582+27207_21240.333333333333336486.0Compositional biasNote=Poly-Glu
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000317582+27311_42440.333333333333336486.0Compositional biasNote=Glu-rich
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000337612+25207_2120324.0Compositional biasNote=Poly-Glu
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000337612+25311_4240324.0Compositional biasNote=Glu-rich
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000399782+37207_21240.333333333333336202.0Compositional biasNote=Poly-Glu
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000399782+37311_42440.333333333333336202.0Compositional biasNote=Glu-rich
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000493680+26207_21240.333333333333336202.0Compositional biasNote=Poly-Glu
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000493680+26311_42440.333333333333336202.0Compositional biasNote=Glu-rich
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000543133+26207_2120324.0Compositional biasNote=Poly-Glu
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000543133+26311_4240324.0Compositional biasNote=Glu-rich
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000317582+27207_21240.333333333333336486.0Compositional biasNote=Poly-Glu
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000317582+27311_42440.333333333333336486.0Compositional biasNote=Glu-rich
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000337612+25207_2120324.0Compositional biasNote=Poly-Glu
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000337612+25311_4240324.0Compositional biasNote=Glu-rich
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000399782+37207_21240.333333333333336202.0Compositional biasNote=Poly-Glu
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000399782+37311_42440.333333333333336202.0Compositional biasNote=Glu-rich
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000493680+26207_21240.333333333333336202.0Compositional biasNote=Poly-Glu
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000493680+26311_42440.333333333333336202.0Compositional biasNote=Glu-rich
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000543133+26207_2120324.0Compositional biasNote=Poly-Glu
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000543133+26311_4240324.0Compositional biasNote=Glu-rich
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000317582+27100_11640.333333333333336486.0MotifNote=BH3
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000317582+27147_15740.333333333333336486.0MotifNote=BH1
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000317582+27193_20640.333333333333336486.0MotifNote=BH2
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000337612+25100_1160324.0MotifNote=BH3
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000337612+25147_1570324.0MotifNote=BH1
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000337612+2514_300324.0MotifNote=BH4
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000337612+25193_2060324.0MotifNote=BH2
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000399782+37100_11640.333333333333336202.0MotifNote=BH3
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000399782+37147_15740.333333333333336202.0MotifNote=BH1
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000399782+37193_20640.333333333333336202.0MotifNote=BH2
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000493680+26100_11640.333333333333336202.0MotifNote=BH3
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000493680+26147_15740.333333333333336202.0MotifNote=BH1
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000493680+26193_20640.333333333333336202.0MotifNote=BH2
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000543133+26100_1160324.0MotifNote=BH3
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000543133+26147_1570324.0MotifNote=BH1
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000543133+2614_300324.0MotifNote=BH4
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000543133+26193_2060324.0MotifNote=BH2
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000317582+27100_11640.333333333333336486.0MotifNote=BH3
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000317582+27147_15740.333333333333336486.0MotifNote=BH1
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000317582+27193_20640.333333333333336486.0MotifNote=BH2
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000337612+25100_1160324.0MotifNote=BH3
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000337612+25147_1570324.0MotifNote=BH1
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000337612+2514_300324.0MotifNote=BH4
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000337612+25193_2060324.0MotifNote=BH2
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000399782+37100_11640.333333333333336202.0MotifNote=BH3
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000399782+37147_15740.333333333333336202.0MotifNote=BH1
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000399782+37193_20640.333333333333336202.0MotifNote=BH2
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000493680+26100_11640.333333333333336202.0MotifNote=BH3
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000493680+26147_15740.333333333333336202.0MotifNote=BH1
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000493680+26193_20640.333333333333336202.0MotifNote=BH2
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000543133+26100_1160324.0MotifNote=BH3
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000543133+26147_1570324.0MotifNote=BH1
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000543133+2614_300324.0MotifNote=BH4
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000543133+26193_2060324.0MotifNote=BH2
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000317582+27246_25640.333333333333336486.0RepeatNote=A
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000317582+27261_27140.333333333333336486.0RepeatNote=A%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000317582+27425_44140.333333333333336486.0RepeatNote=B
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000317582+27443_45940.333333333333336486.0RepeatNote=B%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000337612+25246_2560324.0RepeatNote=A
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000337612+25261_2710324.0RepeatNote=A%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000337612+25425_4410324.0RepeatNote=B
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000337612+25443_4590324.0RepeatNote=B%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000399782+37246_25640.333333333333336202.0RepeatNote=A
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000399782+37261_27140.333333333333336202.0RepeatNote=A%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000399782+37425_44140.333333333333336202.0RepeatNote=B
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000399782+37443_45940.333333333333336202.0RepeatNote=B%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000493680+26246_25640.333333333333336202.0RepeatNote=A
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000493680+26261_27140.333333333333336202.0RepeatNote=A%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000493680+26425_44140.333333333333336202.0RepeatNote=B
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000493680+26443_45940.333333333333336202.0RepeatNote=B%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000543133+26246_2560324.0RepeatNote=A
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000543133+26261_2710324.0RepeatNote=A%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000543133+26425_4410324.0RepeatNote=B
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000543133+26443_4590324.0RepeatNote=B%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000317582+27246_25640.333333333333336486.0RepeatNote=A
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000317582+27261_27140.333333333333336486.0RepeatNote=A%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000317582+27425_44140.333333333333336486.0RepeatNote=B
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000317582+27443_45940.333333333333336486.0RepeatNote=B%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000337612+25246_2560324.0RepeatNote=A
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000337612+25261_2710324.0RepeatNote=A%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000337612+25425_4410324.0RepeatNote=B
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000337612+25443_4590324.0RepeatNote=B%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000399782+37246_25640.333333333333336202.0RepeatNote=A
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000399782+37261_27140.333333333333336202.0RepeatNote=A%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000399782+37425_44140.333333333333336202.0RepeatNote=B
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000399782+37443_45940.333333333333336202.0RepeatNote=B%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000493680+26246_25640.333333333333336202.0RepeatNote=A
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000493680+26261_27140.333333333333336202.0RepeatNote=A%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000493680+26425_44140.333333333333336202.0RepeatNote=B
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000493680+26443_45940.333333333333336202.0RepeatNote=B%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000543133+26246_2560324.0RepeatNote=A
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000543133+26261_2710324.0RepeatNote=A%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000543133+26425_4410324.0RepeatNote=B
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000543133+26443_4590324.0RepeatNote=B%3B approximate
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000317582+27460_48040.333333333333336486.0TransmembraneHelical
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000337612+25460_4800324.0TransmembraneHelical
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000399782+37460_48040.333333333333336202.0TransmembraneHelical
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000493680+26460_48040.333333333333336202.0TransmembraneHelical
HgeneBCL2L13chr22:18138598chr12:111772244ENST00000543133+26460_4800324.0TransmembraneHelical
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000317582+27460_48040.333333333333336486.0TransmembraneHelical
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000337612+25460_4800324.0TransmembraneHelical
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000399782+37460_48040.333333333333336202.0TransmembraneHelical
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000493680+26460_48040.333333333333336202.0TransmembraneHelical
HgeneBCL2L13chr22:18138598chr12:111772245ENST00000543133+26460_4800324.0TransmembraneHelical
TgeneCUX2chr22:18138598chr12:111772244ENST000002617261722195_374975.33333333333341487.0Coiled coilOntology_term=ECO:0000255
TgeneCUX2chr22:18138598chr12:111772244ENST000002617261722690_717975.33333333333341487.0Coiled coilOntology_term=ECO:0000255
TgeneCUX2chr22:18138598chr12:111772245ENST000002617261722195_374975.33333333333341487.0Coiled coilOntology_term=ECO:0000255
TgeneCUX2chr22:18138598chr12:111772245ENST000002617261722690_717975.33333333333341487.0Coiled coilOntology_term=ECO:0000255
TgeneCUX2chr22:18138598chr12:111772244ENST000002617261722440_535975.33333333333341487.0Compositional biasNote=Pro-rich
TgeneCUX2chr22:18138598chr12:111772244ENST000002617261722802_813975.33333333333341487.0Compositional biasNote=Poly-Ser
TgeneCUX2chr22:18138598chr12:111772245ENST000002617261722440_535975.33333333333341487.0Compositional biasNote=Pro-rich
TgeneCUX2chr22:18138598chr12:111772245ENST000002617261722802_813975.33333333333341487.0Compositional biasNote=Poly-Ser
TgeneCUX2chr22:18138598chr12:111772244ENST000002617261722544_631975.33333333333341487.0DNA bindingCUT 1
TgeneCUX2chr22:18138598chr12:111772244ENST000002617261722887_974975.33333333333341487.0DNA bindingCUT 2
TgeneCUX2chr22:18138598chr12:111772245ENST000002617261722544_631975.33333333333341487.0DNA bindingCUT 1
TgeneCUX2chr22:18138598chr12:111772245ENST000002617261722887_974975.33333333333341487.0DNA bindingCUT 2


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1180_BCL2L13_18138598_CUX2_111772245_1180_BCL2L13_18138598_CUX2_111772245_ranked_0.pdbBCL2L131813859818138598ENST00000261726CUX2chr12111772245+
MASSSTVPLGFHYETKYVVLSYLGLLSQEKLQEQHLSSPQASPTEPRSSPSPPPSPTEPEKSSQEPLSLSLESSKENQQPEGRSSSSLSG
KMYSGSQAPGGIQEIVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLNDPHN
VEKLRDMKKLEKKAYLKRRYGLISTGSDSESPATRSECPSPCLQPQDLSLLQIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQL
NLKTNTVINWFHNYRSRMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKELELQEGPEENSTPLTTQDKAQ
VRIKQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPPGNDGLPKVAPGPLLPGGSTPDCPSLHPQQESEAGERLHPDPLSFKSASE
SSRCSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISPSPPGAPPAKVPSASPTADMAGALHPSAKVNPNLQRRHEKMANLNNIIYRVERA
551


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
BCL2L13_pLDDT.png
all structure
all structure
CUX2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
BCL2L13
CUX2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to BCL2L13-CUX2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to BCL2L13-CUX2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource