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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TTLL5-JDP2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TTLL5-JDP2
FusionPDB ID: 95182
FusionGDB2.0 ID: 95182
HgeneTgene
Gene symbol

TTLL5

JDP2

Gene ID

254173

122953

Gene nametubulin tyrosine ligase like 10Jun dimerization protein 2
SynonymsTTLL5JUNDM2
Cytomap

1p36.33

14q24.3

Type of geneprotein-codingprotein-coding
Descriptioninactive polyglycylase TTLL10tubulin tyrosine ligase-like family, member 10tubulin tyrosine ligase-like family, member 5tubulin--tyrosine ligase-like protein 10jun dimerization protein 2progesterone receptor co-activator
Modification date2020031320200313
UniProtAcc.

Q8WYK2

Ensembl transtripts involved in fusion geneENST idsENST00000286650, ENST00000298832, 
ENST00000556977, ENST00000557636, 
ENST00000554510, ENST00000556893, 
ENST00000555422, 		ENST00000559773, 
ENST00000267569, ENST00000419727, 
ENST00000435893, ENST00000437176, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score22 X 22 X 16=77444 X 5 X 4=80
# samples 316
** MAII scorelog2(31/7744*10)=-4.64273883200036
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TTLL5 [Title/Abstract] AND JDP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TTLL5(76259443)-JDP2(75928128), # samples:2
TTLL5(76129566)-JDP2(75904601), # samples:2
Anticipated loss of major functional domain due to fusion event.TTLL5-JDP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TTLL5-JDP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TTLL5-JDP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TTLL5-JDP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTTLL5

GO:0018094

protein polyglycylation

19524510

TgeneJDP2

GO:0000122

negative regulation of transcription by RNA polymerase II

18671972


check buttonFusion gene breakpoints across TTLL5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across JDP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A4OQ-01ATTLL5chr14

76259443

-JDP2chr14

75928129

+
ChimerDB4ESCATCGA-L5-A4OQTTLL5chr14

76259443

+JDP2chr14

75928128

+
ChimerDB4LIHCTCGA-BC-4073-01BTTLL5chr14

76129566

-JDP2chr14

75904601

+
ChimerDB4LIHCTCGA-BC-4073-01BTTLL5chr14

76129566

+JDP2chr14

75904601

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000557636TTLL5chr1476259443+ENST00000419727JDP2chr1475928128+4045343121537211168
ENST00000298832TTLL5chr1476259443+ENST00000419727JDP2chr1475928128+3990337620536661153
ENST00000556893TTLL5chr1476259443+ENST00000419727JDP2chr1475928128+25081894432184713
ENST00000554510TTLL5chr1476259443+ENST00000419727JDP2chr1475928128+243118171192107662
ENST00000557636TTLL5chr1476259443-ENST00000419727JDP2chr1475928129+4045343121537211168
ENST00000298832TTLL5chr1476259443-ENST00000419727JDP2chr1475928129+3990337620536661153
ENST00000556893TTLL5chr1476259443-ENST00000419727JDP2chr1475928129+25081894432184713
ENST00000554510TTLL5chr1476259443-ENST00000419727JDP2chr1475928129+243118171192107662

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000557636ENST00000419727TTLL5chr1476259443+JDP2chr1475928128+0.0028176780.99718237
ENST00000298832ENST00000419727TTLL5chr1476259443+JDP2chr1475928128+0.0023079990.997692
ENST00000556893ENST00000419727TTLL5chr1476259443+JDP2chr1475928128+0.0118348650.98816514
ENST00000554510ENST00000419727TTLL5chr1476259443+JDP2chr1475928128+0.0309174210.96908253
ENST00000557636ENST00000419727TTLL5chr1476259443-JDP2chr1475928129+0.0028176780.99718237
ENST00000298832ENST00000419727TTLL5chr1476259443-JDP2chr1475928129+0.0023079990.997692
ENST00000556893ENST00000419727TTLL5chr1476259443-JDP2chr1475928129+0.0118348650.98816514
ENST00000554510ENST00000419727TTLL5chr1476259443-JDP2chr1475928129+0.0309174210.96908253

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>95182_95182_1_TTLL5-JDP2_TTLL5_chr14_76259443_ENST00000298832_JDP2_chr14_75928128_ENST00000419727_length(amino acids)=1153AA_BP=1056
MPIVMARDLEETASSSEDEEVISQEDHPCIMWTGGCRRIPVLVFHADAILTKDNNIRVIGERYHLSYKIVRTDSRLVRSILTAHGFHEVH
PSSTDYNLMWTGSHLKPFLLRTLSEAQKVNHFPRSYELTRKDRLYKNIIRMQHTHGFKAFHILPQTFLLPAEYAEFCNSYSKDRGPWIVK
PVASSRGRGVYLINNPNQISLEENILVSRYINNPLLIDDFKFDVRLYVLVTSYDPLVIYLYEEGLARFATVRYDQGAKNIRNQFMHLTNY
SVNKKSGDYVSCDDPEVEDYGNKWSMSAMLRYLKQEGRDTTALMAHVEDLIIKTIISAELAIATACKTFVPHRSSCFELYGFDVLIDSTL
KPWLLEVNLSPSLACDAPLDLKIKASMISDMFTVVGFVCQDPAQRASTRPIYPTFESSRRNPFQKPQRCRPLSASDAEMKNLVGSAREKG
PGKLGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYMLATRLFQDRMTADGAPELKIESLNSKAKLHAA
LYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPAEMNVKTETESEEEEEVALDNEDEEQEASQEESAGFLRENQAKYTPSLTALVENTP
KENSMKVREWNNKGGHCCKLETQELEPKFNLMQILQDNGNLSKMQARIAFSAYLQHVQIRLMKDSGGQTFSASWAAKEDEQMELVVRFLK
RASNNLQHSLRMVLPSRRLALLERRRILAHQLGDFIIVYNKETEQMAEKKSKKKVEEEEEDGVNMENFQEFIRQASEAELEEVLTFYTQK
NKSASVFLGTHSKISKNNNNYSDSGAKGDHPETIMEEVKIKPPKQQQTTEIHSDKLSRFTTSAEKEAKLVYSNSSSGPTATLQKIPNTHL
SSVTTSDLSPGPCHHSSLSQIPSAIPSMPHQPTILLNTVSASASPCLHPGAQNIPSPTGLPRCRSGSHTIGPFSSFQSAAHIYSQKLSRP
SSAKAGSCYLNKHHSGIAKTQKEGEDASLYSKRYNQSMVTAELQRLAEKQAARQYSPSSHINLLTQQLDEEEERRKRRREKNKVAAARCR

--------------------------------------------------------------

>95182_95182_2_TTLL5-JDP2_TTLL5_chr14_76259443_ENST00000298832_JDP2_chr14_75928129_ENST00000419727_length(amino acids)=1153AA_BP=1056
MPIVMARDLEETASSSEDEEVISQEDHPCIMWTGGCRRIPVLVFHADAILTKDNNIRVIGERYHLSYKIVRTDSRLVRSILTAHGFHEVH
PSSTDYNLMWTGSHLKPFLLRTLSEAQKVNHFPRSYELTRKDRLYKNIIRMQHTHGFKAFHILPQTFLLPAEYAEFCNSYSKDRGPWIVK
PVASSRGRGVYLINNPNQISLEENILVSRYINNPLLIDDFKFDVRLYVLVTSYDPLVIYLYEEGLARFATVRYDQGAKNIRNQFMHLTNY
SVNKKSGDYVSCDDPEVEDYGNKWSMSAMLRYLKQEGRDTTALMAHVEDLIIKTIISAELAIATACKTFVPHRSSCFELYGFDVLIDSTL
KPWLLEVNLSPSLACDAPLDLKIKASMISDMFTVVGFVCQDPAQRASTRPIYPTFESSRRNPFQKPQRCRPLSASDAEMKNLVGSAREKG
PGKLGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYMLATRLFQDRMTADGAPELKIESLNSKAKLHAA
LYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPAEMNVKTETESEEEEEVALDNEDEEQEASQEESAGFLRENQAKYTPSLTALVENTP
KENSMKVREWNNKGGHCCKLETQELEPKFNLMQILQDNGNLSKMQARIAFSAYLQHVQIRLMKDSGGQTFSASWAAKEDEQMELVVRFLK
RASNNLQHSLRMVLPSRRLALLERRRILAHQLGDFIIVYNKETEQMAEKKSKKKVEEEEEDGVNMENFQEFIRQASEAELEEVLTFYTQK
NKSASVFLGTHSKISKNNNNYSDSGAKGDHPETIMEEVKIKPPKQQQTTEIHSDKLSRFTTSAEKEAKLVYSNSSSGPTATLQKIPNTHL
SSVTTSDLSPGPCHHSSLSQIPSAIPSMPHQPTILLNTVSASASPCLHPGAQNIPSPTGLPRCRSGSHTIGPFSSFQSAAHIYSQKLSRP
SSAKAGSCYLNKHHSGIAKTQKEGEDASLYSKRYNQSMVTAELQRLAEKQAARQYSPSSHINLLTQQLDEEEERRKRRREKNKVAAARCR

--------------------------------------------------------------

>95182_95182_3_TTLL5-JDP2_TTLL5_chr14_76259443_ENST00000554510_JDP2_chr14_75928128_ENST00000419727_length(amino acids)=662AA_BP=565
MNYMLATRLFQDRGNPRRSLLTGRTRMTADGAPELKIESLNSKAKLHAALYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPAEMNVKT
ETESEEEEEVALDNEDEEQEASQEESAGFLRENQAKYTPSLTALVENTPKENSMKVREWNNKGGHCCKLETQELEPKFNLMQILQDNGNL
SKMQARIAFSAYLQHVQIRLMKDSGGQTFSASWAAKEDEQMELVVRFLKRASNNLQHSLRMVLPSRRLALLERRRILAHQLGDFIIVYNK
ETEQMAEKKSKKKVEEEEEDGVNMENFQEFIRQASEAELEEVLTFYTQKNKSASVFLGTHSKISKNNNNYSDSGAKGDHPETIMEEVKIK
PPKQQQTTEIHSDKLSRFTTSAEKEAKLVYSNSSSGPTATLQKIPNTHLSSVTTSDLSPGPCHHSSLSQIPSAIPSMPHQPTILLNTVSA
SASPCLHPGAQNIPSPTGLPRCRSGSHTIGPFSSFQSAAHIYSQKLSRPSSAKAGSCYLNKHHSGIAKTQKEGEDASLYSKRYNQSMVTA
ELQRLAEKQAARQYSPSSHINLLTQQLDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEELKQERQQLILM

--------------------------------------------------------------

>95182_95182_4_TTLL5-JDP2_TTLL5_chr14_76259443_ENST00000554510_JDP2_chr14_75928129_ENST00000419727_length(amino acids)=662AA_BP=565
MNYMLATRLFQDRGNPRRSLLTGRTRMTADGAPELKIESLNSKAKLHAALYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPAEMNVKT
ETESEEEEEVALDNEDEEQEASQEESAGFLRENQAKYTPSLTALVENTPKENSMKVREWNNKGGHCCKLETQELEPKFNLMQILQDNGNL
SKMQARIAFSAYLQHVQIRLMKDSGGQTFSASWAAKEDEQMELVVRFLKRASNNLQHSLRMVLPSRRLALLERRRILAHQLGDFIIVYNK
ETEQMAEKKSKKKVEEEEEDGVNMENFQEFIRQASEAELEEVLTFYTQKNKSASVFLGTHSKISKNNNNYSDSGAKGDHPETIMEEVKIK
PPKQQQTTEIHSDKLSRFTTSAEKEAKLVYSNSSSGPTATLQKIPNTHLSSVTTSDLSPGPCHHSSLSQIPSAIPSMPHQPTILLNTVSA
SASPCLHPGAQNIPSPTGLPRCRSGSHTIGPFSSFQSAAHIYSQKLSRPSSAKAGSCYLNKHHSGIAKTQKEGEDASLYSKRYNQSMVTA
ELQRLAEKQAARQYSPSSHINLLTQQLDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEELKQERQQLILM

--------------------------------------------------------------

>95182_95182_5_TTLL5-JDP2_TTLL5_chr14_76259443_ENST00000556893_JDP2_chr14_75928128_ENST00000419727_length(amino acids)=713AA_BP=616
MGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYMLATRLFQDRGNPRRSLLTGRTRMTADGAPELKIES
LNSKAKLHAALYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPAEMNVKTETESEEEEEVALDNEDEEQEASQEESAGFLRENQAKYTP
SLTALVENTPKENSMKVREWNNKGGHCCKLETQELEPKFNLMQILQDNGNLSKMQARIAFSAYLQHVQIRLMKDSGGQTFSASWAAKEDE
QMELVVRFLKRASNNLQHSLRMVLPSRRLALLERRRILAHQLGDFIIVYNKETEQMAEKKSKKKVEEEEEDGVNMENFQEFIRQASEAEL
EEVLTFYTQKNKSASVFLGTHSKISKNNNNYSDSGAKGDHPETIMEEVKIKPPKQQQTTEIHSDKLSRFTTSAEKEAKLVYSNSSSGPTA
TLQKIPNTHLSSVTTSDLSPGPCHHSSLSQIPSAIPSMPHQPTILLNTVSASASPCLHPGAQNIPSPTGLPRCRSGSHTIGPFSSFQSAA
HIYSQKLSRPSSAKAGSCYLNKHHSGIAKTQKEGEDASLYSKRYNQSMVTAELQRLAEKQAARQYSPSSHINLLTQQLDEEEERRKRRRE

--------------------------------------------------------------

>95182_95182_6_TTLL5-JDP2_TTLL5_chr14_76259443_ENST00000556893_JDP2_chr14_75928129_ENST00000419727_length(amino acids)=713AA_BP=616
MGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYMLATRLFQDRGNPRRSLLTGRTRMTADGAPELKIES
LNSKAKLHAALYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPAEMNVKTETESEEEEEVALDNEDEEQEASQEESAGFLRENQAKYTP
SLTALVENTPKENSMKVREWNNKGGHCCKLETQELEPKFNLMQILQDNGNLSKMQARIAFSAYLQHVQIRLMKDSGGQTFSASWAAKEDE
QMELVVRFLKRASNNLQHSLRMVLPSRRLALLERRRILAHQLGDFIIVYNKETEQMAEKKSKKKVEEEEEDGVNMENFQEFIRQASEAEL
EEVLTFYTQKNKSASVFLGTHSKISKNNNNYSDSGAKGDHPETIMEEVKIKPPKQQQTTEIHSDKLSRFTTSAEKEAKLVYSNSSSGPTA
TLQKIPNTHLSSVTTSDLSPGPCHHSSLSQIPSAIPSMPHQPTILLNTVSASASPCLHPGAQNIPSPTGLPRCRSGSHTIGPFSSFQSAA
HIYSQKLSRPSSAKAGSCYLNKHHSGIAKTQKEGEDASLYSKRYNQSMVTAELQRLAEKQAARQYSPSSHINLLTQQLDEEEERRKRRRE

--------------------------------------------------------------

>95182_95182_7_TTLL5-JDP2_TTLL5_chr14_76259443_ENST00000557636_JDP2_chr14_75928128_ENST00000419727_length(amino acids)=1168AA_BP=1071
MPIVMARDLEETASSSEDEEVISQEDHPCIMWTGGCRRIPVLVFHADAILTKDNNIRVIGERYHLSYKIVRTDSRLVRSILTAHGFHEVH
PSSTDYNLMWTGSHLKPFLLRTLSEAQKVNHFPRSYELTRKDRLYKNIIRMQHTHGFKAFHILPQTFLLPAEYAEFCNSYSKDRGPWIVK
PVASSRGRGVYLINNPNQISLEENILVSRYINNPLLIDDFKFDVRLYVLVTSYDPLVIYLYEEGLARFATVRYDQGAKNIRNQFMHLTNY
SVNKKSGDYVSCDDPEVEDYGNKWSMSAMLRYLKQEGRDTTALMAHVEDLIIKTIISAELAIATACKTFVPHRSSCFELYGFDVLIDSTL
KPWLLEVNLSPSLACDAPLDLKIKASMISDMFTVVGFVCQDPAQRASTRPIYPTFESSRRNPFQKPQRPVSAQFQSSKAKQRCRPLSASD
AEMKNLVGSAREKGPGKLGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYMLATRLFQDRMTADGAPEL
KIESLNSKAKLHAALYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPAEMNVKTETESEEEEEVALDNEDEEQEASQEESAGFLRENQA
KYTPSLTALVENTPKENSMKVREWNNKGGHCCKLETQELEPKFNLMQILQDNGNLSKMQARIAFSAYLQHVQIRLMKDSGGQTFSASWAA
KEDEQMELVVRFLKRASNNLQHSLRMVLPSRRLALLERRRILAHQLGDFIIVYNKETEQMAEKKSKKKVEEEEEDGVNMENFQEFIRQAS
EAELEEVLTFYTQKNKSASVFLGTHSKISKNNNNYSDSGAKGDHPETIMEEVKIKPPKQQQTTEIHSDKLSRFTTSAEKEAKLVYSNSSS
GPTATLQKIPNTHLSSVTTSDLSPGPCHHSSLSQIPSAIPSMPHQPTILLNTVSASASPCLHPGAQNIPSPTGLPRCRSGSHTIGPFSSF
QSAAHIYSQKLSRPSSAKAAGSCYLNKHHSGIAKTQKEGEDASLYSKRYNQSMVTAELQRLAEKQAARQYSPSSHINLLTQQLDEEEERR

--------------------------------------------------------------

>95182_95182_8_TTLL5-JDP2_TTLL5_chr14_76259443_ENST00000557636_JDP2_chr14_75928129_ENST00000419727_length(amino acids)=1168AA_BP=1071
MPIVMARDLEETASSSEDEEVISQEDHPCIMWTGGCRRIPVLVFHADAILTKDNNIRVIGERYHLSYKIVRTDSRLVRSILTAHGFHEVH
PSSTDYNLMWTGSHLKPFLLRTLSEAQKVNHFPRSYELTRKDRLYKNIIRMQHTHGFKAFHILPQTFLLPAEYAEFCNSYSKDRGPWIVK
PVASSRGRGVYLINNPNQISLEENILVSRYINNPLLIDDFKFDVRLYVLVTSYDPLVIYLYEEGLARFATVRYDQGAKNIRNQFMHLTNY
SVNKKSGDYVSCDDPEVEDYGNKWSMSAMLRYLKQEGRDTTALMAHVEDLIIKTIISAELAIATACKTFVPHRSSCFELYGFDVLIDSTL
KPWLLEVNLSPSLACDAPLDLKIKASMISDMFTVVGFVCQDPAQRASTRPIYPTFESSRRNPFQKPQRPVSAQFQSSKAKQRCRPLSASD
AEMKNLVGSAREKGPGKLGGSVLGLSMEEIKVLRRVKEENDRRGGFIRIFPTSETWEIYGSYLEHKTSMNYMLATRLFQDRMTADGAPEL
KIESLNSKAKLHAALYERKLLSLEVRKRRRRSSRLRAMRPKYPVITQPAEMNVKTETESEEEEEVALDNEDEEQEASQEESAGFLRENQA
KYTPSLTALVENTPKENSMKVREWNNKGGHCCKLETQELEPKFNLMQILQDNGNLSKMQARIAFSAYLQHVQIRLMKDSGGQTFSASWAA
KEDEQMELVVRFLKRASNNLQHSLRMVLPSRRLALLERRRILAHQLGDFIIVYNKETEQMAEKKSKKKVEEEEEDGVNMENFQEFIRQAS
EAELEEVLTFYTQKNKSASVFLGTHSKISKNNNNYSDSGAKGDHPETIMEEVKIKPPKQQQTTEIHSDKLSRFTTSAEKEAKLVYSNSSS
GPTATLQKIPNTHLSSVTTSDLSPGPCHHSSLSQIPSAIPSMPHQPTILLNTVSASASPCLHPGAQNIPSPTGLPRCRSGSHTIGPFSSF
QSAAHIYSQKLSRPSSAKAAGSCYLNKHHSGIAKTQKEGEDASLYSKRYNQSMVTAELQRLAEKQAARQYSPSSHINLLTQQLDEEEERR

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:76259443/chr14:75928128)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.JDP2

Q8WYK2

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. {ECO:0000269|PubMed:12707301, ECO:0000269|PubMed:12903123, ECO:0000269|PubMed:16026868, ECO:0000269|PubMed:16518400}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTLL5chr14:76259443chr14:75928128ENST00000298832+2732552_5571057.01282.0Compositional biasNote=Poly-Arg
HgeneTTLL5chr14:76259443chr14:75928128ENST00000298832+2732582_5901057.01282.0Compositional biasNote=Poly-Glu
HgeneTTLL5chr14:76259443chr14:75928128ENST00000298832+2732776_7801057.01282.0Compositional biasNote=Poly-Glu
HgeneTTLL5chr14:76259443chr14:75928128ENST00000298832+2732827_8301057.01282.0Compositional biasNote=Poly-Asn
HgeneTTLL5chr14:76259443chr14:75928128ENST00000556893+1317552_557608.0818.0Compositional biasNote=Poly-Arg
HgeneTTLL5chr14:76259443chr14:75928128ENST00000556893+1317582_590608.0818.0Compositional biasNote=Poly-Glu
HgeneTTLL5chr14:76259443chr14:75928129ENST00000298832-2732552_5571057.01282.0Compositional biasNote=Poly-Arg
HgeneTTLL5chr14:76259443chr14:75928129ENST00000298832-2732582_5901057.01282.0Compositional biasNote=Poly-Glu
HgeneTTLL5chr14:76259443chr14:75928129ENST00000298832-2732776_7801057.01282.0Compositional biasNote=Poly-Glu
HgeneTTLL5chr14:76259443chr14:75928129ENST00000298832-2732827_8301057.01282.0Compositional biasNote=Poly-Asn
HgeneTTLL5chr14:76259443chr14:75928129ENST00000556893-1317552_557608.0818.0Compositional biasNote=Poly-Arg
HgeneTTLL5chr14:76259443chr14:75928129ENST00000556893-1317582_590608.0818.0Compositional biasNote=Poly-Glu
HgeneTTLL5chr14:76259443chr14:75928128ENST00000298832+273262_4071057.01282.0DomainTTL
HgeneTTLL5chr14:76259443chr14:75928128ENST00000556893+131762_407608.0818.0DomainTTL
HgeneTTLL5chr14:76259443chr14:75928129ENST00000298832-273262_4071057.01282.0DomainTTL
HgeneTTLL5chr14:76259443chr14:75928129ENST00000556893-131762_407608.0818.0DomainTTL
HgeneTTLL5chr14:76259443chr14:75928128ENST00000298832+2732208_2111057.01282.0Nucleotide bindingATP binding
HgeneTTLL5chr14:76259443chr14:75928128ENST00000556893+1317208_211608.0818.0Nucleotide bindingATP binding
HgeneTTLL5chr14:76259443chr14:75928129ENST00000298832-2732208_2111057.01282.0Nucleotide bindingATP binding
HgeneTTLL5chr14:76259443chr14:75928129ENST00000556893-1317208_211608.0818.0Nucleotide bindingATP binding
HgeneTTLL5chr14:76259443chr14:75928128ENST00000298832+2732378_4881057.01282.0Regionc-MTBD region
HgeneTTLL5chr14:76259443chr14:75928128ENST00000556893+1317378_488608.0818.0Regionc-MTBD region
HgeneTTLL5chr14:76259443chr14:75928129ENST00000298832-2732378_4881057.01282.0Regionc-MTBD region
HgeneTTLL5chr14:76259443chr14:75928129ENST00000556893-1317378_488608.0818.0Regionc-MTBD region
TgeneJDP2chr14:76259443chr14:75928128ENST000004197271472_13567.0164.0DomainbZIP
TgeneJDP2chr14:76259443chr14:75928128ENST000004358931472_13567.0164.0DomainbZIP
TgeneJDP2chr14:76259443chr14:75928128ENST000004371761472_13567.0164.0DomainbZIP
TgeneJDP2chr14:76259443chr14:75928129ENST000004197271472_13567.0164.0DomainbZIP
TgeneJDP2chr14:76259443chr14:75928129ENST000004358931472_13567.0164.0DomainbZIP
TgeneJDP2chr14:76259443chr14:75928129ENST000004371761472_13567.0164.0DomainbZIP
TgeneJDP2chr14:76259443chr14:75928128ENST0000026756914100_12878.0175.0RegionLeucine-zipper
TgeneJDP2chr14:76259443chr14:75928128ENST0000041972714100_12867.0164.0RegionLeucine-zipper
TgeneJDP2chr14:76259443chr14:75928128ENST000004197271474_9667.0164.0RegionBasic motif
TgeneJDP2chr14:76259443chr14:75928128ENST0000043589314100_12867.0164.0RegionLeucine-zipper
TgeneJDP2chr14:76259443chr14:75928128ENST000004358931474_9667.0164.0RegionBasic motif
TgeneJDP2chr14:76259443chr14:75928128ENST0000043717614100_12867.0164.0RegionLeucine-zipper
TgeneJDP2chr14:76259443chr14:75928128ENST000004371761474_9667.0164.0RegionBasic motif
TgeneJDP2chr14:76259443chr14:75928129ENST0000026756914100_12878.0175.0RegionLeucine-zipper
TgeneJDP2chr14:76259443chr14:75928129ENST0000041972714100_12867.0164.0RegionLeucine-zipper
TgeneJDP2chr14:76259443chr14:75928129ENST000004197271474_9667.0164.0RegionBasic motif
TgeneJDP2chr14:76259443chr14:75928129ENST0000043589314100_12867.0164.0RegionLeucine-zipper
TgeneJDP2chr14:76259443chr14:75928129ENST000004358931474_9667.0164.0RegionBasic motif
TgeneJDP2chr14:76259443chr14:75928129ENST0000043717614100_12867.0164.0RegionLeucine-zipper
TgeneJDP2chr14:76259443chr14:75928129ENST000004371761474_9667.0164.0RegionBasic motif

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTTLL5chr14:76259443chr14:75928128ENST00000286650+110552_5570270.0Compositional biasNote=Poly-Arg
HgeneTTLL5chr14:76259443chr14:75928128ENST00000286650+110582_5900270.0Compositional biasNote=Poly-Glu
HgeneTTLL5chr14:76259443chr14:75928128ENST00000286650+110776_7800270.0Compositional biasNote=Poly-Glu
HgeneTTLL5chr14:76259443chr14:75928128ENST00000286650+110827_8300270.0Compositional biasNote=Poly-Asn
HgeneTTLL5chr14:76259443chr14:75928128ENST00000556893+1317776_780608.0818.0Compositional biasNote=Poly-Glu
HgeneTTLL5chr14:76259443chr14:75928128ENST00000556893+1317827_830608.0818.0Compositional biasNote=Poly-Asn
HgeneTTLL5chr14:76259443chr14:75928129ENST00000286650-110552_5570270.0Compositional biasNote=Poly-Arg
HgeneTTLL5chr14:76259443chr14:75928129ENST00000286650-110582_5900270.0Compositional biasNote=Poly-Glu
HgeneTTLL5chr14:76259443chr14:75928129ENST00000286650-110776_7800270.0Compositional biasNote=Poly-Glu
HgeneTTLL5chr14:76259443chr14:75928129ENST00000286650-110827_8300270.0Compositional biasNote=Poly-Asn
HgeneTTLL5chr14:76259443chr14:75928129ENST00000556893-1317776_780608.0818.0Compositional biasNote=Poly-Glu
HgeneTTLL5chr14:76259443chr14:75928129ENST00000556893-1317827_830608.0818.0Compositional biasNote=Poly-Asn
HgeneTTLL5chr14:76259443chr14:75928128ENST00000286650+11062_4070270.0DomainTTL
HgeneTTLL5chr14:76259443chr14:75928129ENST00000286650-11062_4070270.0DomainTTL
HgeneTTLL5chr14:76259443chr14:75928128ENST00000286650+110208_2110270.0Nucleotide bindingATP binding
HgeneTTLL5chr14:76259443chr14:75928129ENST00000286650-110208_2110270.0Nucleotide bindingATP binding
HgeneTTLL5chr14:76259443chr14:75928128ENST00000286650+110378_4880270.0Regionc-MTBD region
HgeneTTLL5chr14:76259443chr14:75928129ENST00000286650-110378_4880270.0Regionc-MTBD region
TgeneJDP2chr14:76259443chr14:75928128ENST000002675691472_13578.0175.0DomainbZIP
TgeneJDP2chr14:76259443chr14:75928129ENST000002675691472_13578.0175.0DomainbZIP
TgeneJDP2chr14:76259443chr14:75928128ENST000002675691474_9678.0175.0RegionBasic motif
TgeneJDP2chr14:76259443chr14:75928129ENST000002675691474_9678.0175.0RegionBasic motif


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TTLL5
JDP2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TTLL5-JDP2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TTLL5-JDP2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource