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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TUBB6-ROBO1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TUBB6-ROBO1
FusionPDB ID: 95352
FusionGDB2.0 ID: 95352
HgeneTgene
Gene symbol

TUBB6

ROBO1

Gene ID

84617

6091

Gene nametubulin beta 6 class Vroundabout guidance receptor 1
SynonymsFPVEPD|HsT1601|TUBB-5DUTT1|SAX3
Cytomap

18p11.21

3p12.3

Type of geneprotein-codingprotein-coding
Descriptiontubulin beta-6 chainclass V beta-tubulintubulin beta MGC4083tubulin beta class Vtubulin, beta 6roundabout homolog 1deleted in U twenty twentyroundabout, axon guidance receptor, homolog 1
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000317702, ENST00000586653, 
ENST00000590967, ENST00000591208, 
ENST00000591909, ENST00000592683, 
ENST00000466906, ENST00000467549, 
ENST00000436010, ENST00000464233, 
ENST00000495273, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 4 X 4=8015 X 14 X 5=1050
# samples 515
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1050*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TUBB6 [Title/Abstract] AND ROBO1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TUBB6(12311052)-ROBO1(78685258), # samples:3
Anticipated loss of major functional domain due to fusion event.TUBB6-ROBO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TUBB6-ROBO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TUBB6-ROBO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TUBB6-ROBO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneROBO1

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

12504588

TgeneROBO1

GO:0021836

chemorepulsion involved in postnatal olfactory bulb interneuron migration

15207848

TgeneROBO1

GO:0050772

positive regulation of axonogenesis

12504588

TgeneROBO1

GO:0050925

negative regulation of negative chemotaxis

11748139


check buttonFusion gene breakpoints across TUBB6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ROBO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A5ZV-01ATUBB6chr18

12311052

-ROBO1chr3

78685258

-
ChimerDB4BRCATCGA-A7-A5ZV-01ATUBB6chr18

12311052

+ROBO1chr3

78685258

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000317702TUBB6chr1812311052+ENST00000464233ROBO1chr378685258-41025112342429731
ENST00000317702TUBB6chr1812311052+ENST00000436010ROBO1chr378685258-41035112342429731
ENST00000317702TUBB6chr1812311052+ENST00000495273ROBO1chr378685258-26555112342429731
ENST00000591909TUBB6chr1812311052+ENST00000464233ROBO1chr378685258-3927336592254731
ENST00000591909TUBB6chr1812311052+ENST00000436010ROBO1chr378685258-3928336592254731
ENST00000591909TUBB6chr1812311052+ENST00000495273ROBO1chr378685258-2480336592254731
ENST00000586653TUBB6chr1812311052+ENST00000464233ROBO1chr378685258-3920329522247731
ENST00000586653TUBB6chr1812311052+ENST00000436010ROBO1chr378685258-3921329522247731
ENST00000586653TUBB6chr1812311052+ENST00000495273ROBO1chr378685258-2473329522247731
ENST00000592683TUBB6chr1812311052+ENST00000464233ROBO1chr378685258-3914323462241731
ENST00000592683TUBB6chr1812311052+ENST00000436010ROBO1chr378685258-3915323462241731
ENST00000592683TUBB6chr1812311052+ENST00000495273ROBO1chr378685258-2467323462241731
ENST00000590967TUBB6chr1812311052+ENST00000464233ROBO1chr378685258-3908317402235731
ENST00000590967TUBB6chr1812311052+ENST00000436010ROBO1chr378685258-3909317402235731
ENST00000590967TUBB6chr1812311052+ENST00000495273ROBO1chr378685258-2461317402235731
ENST00000591208TUBB6chr1812311052+ENST00000464233ROBO1chr378685258-3899308312226731
ENST00000591208TUBB6chr1812311052+ENST00000436010ROBO1chr378685258-3900308312226731
ENST00000591208TUBB6chr1812311052+ENST00000495273ROBO1chr378685258-2452308312226731

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000317702ENST00000464233TUBB6chr1812311052+ROBO1chr378685258-0.000699060.99930096
ENST00000317702ENST00000436010TUBB6chr1812311052+ROBO1chr378685258-0.0006990270.99930096
ENST00000317702ENST00000495273TUBB6chr1812311052+ROBO1chr378685258-0.0067368740.9932632
ENST00000591909ENST00000464233TUBB6chr1812311052+ROBO1chr378685258-0.0006575730.9993424
ENST00000591909ENST00000436010TUBB6chr1812311052+ROBO1chr378685258-0.0006575190.9993425
ENST00000591909ENST00000495273TUBB6chr1812311052+ROBO1chr378685258-0.0067721370.9932279
ENST00000586653ENST00000464233TUBB6chr1812311052+ROBO1chr378685258-0.0006484460.99935156
ENST00000586653ENST00000436010TUBB6chr1812311052+ROBO1chr378685258-0.0006483950.99935156
ENST00000586653ENST00000495273TUBB6chr1812311052+ROBO1chr378685258-0.0067329210.99326706
ENST00000592683ENST00000464233TUBB6chr1812311052+ROBO1chr378685258-0.000639240.99936074
ENST00000592683ENST00000436010TUBB6chr1812311052+ROBO1chr378685258-0.0006392850.99936074
ENST00000592683ENST00000495273TUBB6chr1812311052+ROBO1chr378685258-0.0069154210.99308455
ENST00000590967ENST00000464233TUBB6chr1812311052+ROBO1chr378685258-0.0006496840.99935037
ENST00000590967ENST00000436010TUBB6chr1812311052+ROBO1chr378685258-0.0006497280.99935025
ENST00000590967ENST00000495273TUBB6chr1812311052+ROBO1chr378685258-0.0069990410.993001
ENST00000591208ENST00000464233TUBB6chr1812311052+ROBO1chr378685258-0.0006378790.9993622
ENST00000591208ENST00000436010TUBB6chr1812311052+ROBO1chr378685258-0.0006379330.99936205
ENST00000591208ENST00000495273TUBB6chr1812311052+ROBO1chr378685258-0.0068005520.9931994

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>95352_95352_1_TUBB6-ROBO1_TUBB6_chr18_12311052_ENST00000317702_ROBO1_chr3_78685258_ENST00000436010_length(amino acids)=731AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK
PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP
AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPE
ETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSM
INGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRP
AKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDP
REAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGE

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>95352_95352_2_TUBB6-ROBO1_TUBB6_chr18_12311052_ENST00000317702_ROBO1_chr3_78685258_ENST00000464233_length(amino acids)=731AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK
PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP
AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPE
ETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSM
INGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRP
AKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDP
REAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGE

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>95352_95352_3_TUBB6-ROBO1_TUBB6_chr18_12311052_ENST00000317702_ROBO1_chr3_78685258_ENST00000495273_length(amino acids)=731AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK
PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP
AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPE
ETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSM
INGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRP
AKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDP
REAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGE

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>95352_95352_4_TUBB6-ROBO1_TUBB6_chr18_12311052_ENST00000586653_ROBO1_chr3_78685258_ENST00000436010_length(amino acids)=731AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK
PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP
AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPE
ETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSM
INGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRP
AKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDP
REAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGE

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>95352_95352_5_TUBB6-ROBO1_TUBB6_chr18_12311052_ENST00000586653_ROBO1_chr3_78685258_ENST00000464233_length(amino acids)=731AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK
PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP
AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPE
ETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSM
INGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRP
AKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDP
REAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGE

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>95352_95352_6_TUBB6-ROBO1_TUBB6_chr18_12311052_ENST00000586653_ROBO1_chr3_78685258_ENST00000495273_length(amino acids)=731AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK
PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP
AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPE
ETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSM
INGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRP
AKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDP
REAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGE

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>95352_95352_7_TUBB6-ROBO1_TUBB6_chr18_12311052_ENST00000590967_ROBO1_chr3_78685258_ENST00000436010_length(amino acids)=731AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK
PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP
AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPE
ETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSM
INGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRP
AKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDP
REAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGE

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>95352_95352_8_TUBB6-ROBO1_TUBB6_chr18_12311052_ENST00000590967_ROBO1_chr3_78685258_ENST00000464233_length(amino acids)=731AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK
PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP
AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPE
ETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSM
INGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRP
AKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDP
REAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGE

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>95352_95352_9_TUBB6-ROBO1_TUBB6_chr18_12311052_ENST00000590967_ROBO1_chr3_78685258_ENST00000495273_length(amino acids)=731AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK
PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP
AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPE
ETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSM
INGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRP
AKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDP
REAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGE

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>95352_95352_10_TUBB6-ROBO1_TUBB6_chr18_12311052_ENST00000591208_ROBO1_chr3_78685258_ENST00000436010_length(amino acids)=731AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK
PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP
AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPE
ETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSM
INGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRP
AKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDP
REAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGE

--------------------------------------------------------------

>95352_95352_11_TUBB6-ROBO1_TUBB6_chr18_12311052_ENST00000591208_ROBO1_chr3_78685258_ENST00000464233_length(amino acids)=731AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK
PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP
AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPE
ETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSM
INGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRP
AKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDP
REAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGE

--------------------------------------------------------------

>95352_95352_12_TUBB6-ROBO1_TUBB6_chr18_12311052_ENST00000591208_ROBO1_chr3_78685258_ENST00000495273_length(amino acids)=731AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK
PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP
AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPE
ETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSM
INGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRP
AKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDP
REAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGE

--------------------------------------------------------------

>95352_95352_13_TUBB6-ROBO1_TUBB6_chr18_12311052_ENST00000591909_ROBO1_chr3_78685258_ENST00000436010_length(amino acids)=731AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK
PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP
AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPE
ETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSM
INGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRP
AKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDP
REAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGE

--------------------------------------------------------------

>95352_95352_14_TUBB6-ROBO1_TUBB6_chr18_12311052_ENST00000591909_ROBO1_chr3_78685258_ENST00000464233_length(amino acids)=731AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK
PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP
AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPE
ETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSM
INGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRP
AKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDP
REAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGE

--------------------------------------------------------------

>95352_95352_15_TUBB6-ROBO1_TUBB6_chr18_12311052_ENST00000591909_ROBO1_chr3_78685258_ENST00000495273_length(amino acids)=731AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK
PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP
AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPE
ETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSM
INGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRP
AKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDP
REAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGE

--------------------------------------------------------------

>95352_95352_16_TUBB6-ROBO1_TUBB6_chr18_12311052_ENST00000592683_ROBO1_chr3_78685258_ENST00000436010_length(amino acids)=731AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK
PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP
AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPE
ETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSM
INGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRP
AKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDP
REAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGE

--------------------------------------------------------------

>95352_95352_17_TUBB6-ROBO1_TUBB6_chr18_12311052_ENST00000592683_ROBO1_chr3_78685258_ENST00000464233_length(amino acids)=731AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK
PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP
AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPE
ETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSM
INGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRP
AKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDP
REAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGE

--------------------------------------------------------------

>95352_95352_18_TUBB6-ROBO1_TUBB6_chr18_12311052_ENST00000592683_ROBO1_chr3_78685258_ENST00000495273_length(amino acids)=731AA_BP=92
MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYVPRAALVDLEPGTMDSVRSGPFGQLFRPDNF
IFADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWK
PLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP
AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPE
ETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSM
INGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRP
AKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDP
REAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:12311052/chr3:78685258)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneROBO1chr18:12311052chr3:78685258ENST00000467549029170_25701552.0DomainNote=Ig-like C2-type 2
TgeneROBO1chr18:12311052chr3:78685258ENST00000467549029262_34601552.0DomainNote=Ig-like C2-type 3
TgeneROBO1chr18:12311052chr3:78685258ENST00000467549029351_44601552.0DomainNote=Ig-like C2-type 4
TgeneROBO1chr18:12311052chr3:78685258ENST00000467549029455_54101552.0DomainNote=Ig-like C2-type 5
TgeneROBO1chr18:12311052chr3:78685258ENST00000467549029563_65701552.0DomainFibronectin type-III 1
TgeneROBO1chr18:12311052chr3:78685258ENST00000467549029676_77301552.0DomainFibronectin type-III 2
TgeneROBO1chr18:12311052chr3:78685258ENST0000046754902968_16401552.0DomainNote=Ig-like C2-type 1
TgeneROBO1chr18:12311052chr3:78685258ENST00000467549029778_87401552.0DomainFibronectin type-III 3
TgeneROBO1chr18:12311052chr3:78685258ENST0000046754902926_89701552.0Topological domainExtracellular
TgeneROBO1chr18:12311052chr3:78685258ENST00000467549029919_165101552.0Topological domainCytoplasmic
TgeneROBO1chr18:12311052chr3:78685258ENST00000467549029898_91801552.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTUBB6chr18:12311052chr3:78685258ENST00000317702+34140_14692.33333333333333447.0Nucleotide bindingGTP
TgeneROBO1chr18:12311052chr3:78685258ENST000004360101929170_257973.33333333333341613.0DomainNote=Ig-like C2-type 2
TgeneROBO1chr18:12311052chr3:78685258ENST000004360101929262_346973.33333333333341613.0DomainNote=Ig-like C2-type 3
TgeneROBO1chr18:12311052chr3:78685258ENST000004360101929351_446973.33333333333341613.0DomainNote=Ig-like C2-type 4
TgeneROBO1chr18:12311052chr3:78685258ENST000004360101929455_541973.33333333333341613.0DomainNote=Ig-like C2-type 5
TgeneROBO1chr18:12311052chr3:78685258ENST000004360101929563_657973.33333333333341613.0DomainFibronectin type-III 1
TgeneROBO1chr18:12311052chr3:78685258ENST000004360101929676_773973.33333333333341613.0DomainFibronectin type-III 2
TgeneROBO1chr18:12311052chr3:78685258ENST00000436010192968_164973.33333333333341613.0DomainNote=Ig-like C2-type 1
TgeneROBO1chr18:12311052chr3:78685258ENST000004360101929778_874973.33333333333341613.0DomainFibronectin type-III 3
TgeneROBO1chr18:12311052chr3:78685258ENST000004642332131170_2571012.33333333333341652.0DomainNote=Ig-like C2-type 2
TgeneROBO1chr18:12311052chr3:78685258ENST000004642332131262_3461012.33333333333341652.0DomainNote=Ig-like C2-type 3
TgeneROBO1chr18:12311052chr3:78685258ENST000004642332131351_4461012.33333333333341652.0DomainNote=Ig-like C2-type 4
TgeneROBO1chr18:12311052chr3:78685258ENST000004642332131455_5411012.33333333333341652.0DomainNote=Ig-like C2-type 5
TgeneROBO1chr18:12311052chr3:78685258ENST000004642332131563_6571012.33333333333341652.0DomainFibronectin type-III 1
TgeneROBO1chr18:12311052chr3:78685258ENST000004642332131676_7731012.33333333333341652.0DomainFibronectin type-III 2
TgeneROBO1chr18:12311052chr3:78685258ENST00000464233213168_1641012.33333333333341652.0DomainNote=Ig-like C2-type 1
TgeneROBO1chr18:12311052chr3:78685258ENST000004642332131778_8741012.33333333333341652.0DomainFibronectin type-III 3
TgeneROBO1chr18:12311052chr3:78685258ENST000004952731929170_257967.33333333333341607.0DomainNote=Ig-like C2-type 2
TgeneROBO1chr18:12311052chr3:78685258ENST000004952731929262_346967.33333333333341607.0DomainNote=Ig-like C2-type 3
TgeneROBO1chr18:12311052chr3:78685258ENST000004952731929351_446967.33333333333341607.0DomainNote=Ig-like C2-type 4
TgeneROBO1chr18:12311052chr3:78685258ENST000004952731929455_541967.33333333333341607.0DomainNote=Ig-like C2-type 5
TgeneROBO1chr18:12311052chr3:78685258ENST000004952731929563_657967.33333333333341607.0DomainFibronectin type-III 1
TgeneROBO1chr18:12311052chr3:78685258ENST000004952731929676_773967.33333333333341607.0DomainFibronectin type-III 2
TgeneROBO1chr18:12311052chr3:78685258ENST00000495273192968_164967.33333333333341607.0DomainNote=Ig-like C2-type 1
TgeneROBO1chr18:12311052chr3:78685258ENST000004952731929778_874967.33333333333341607.0DomainFibronectin type-III 3
TgeneROBO1chr18:12311052chr3:78685258ENST00000436010192926_897973.33333333333341613.0Topological domainExtracellular
TgeneROBO1chr18:12311052chr3:78685258ENST000004360101929919_1651973.33333333333341613.0Topological domainCytoplasmic
TgeneROBO1chr18:12311052chr3:78685258ENST00000464233213126_8971012.33333333333341652.0Topological domainExtracellular
TgeneROBO1chr18:12311052chr3:78685258ENST000004642332131919_16511012.33333333333341652.0Topological domainCytoplasmic
TgeneROBO1chr18:12311052chr3:78685258ENST00000495273192926_897967.33333333333341607.0Topological domainExtracellular
TgeneROBO1chr18:12311052chr3:78685258ENST000004952731929919_1651967.33333333333341607.0Topological domainCytoplasmic
TgeneROBO1chr18:12311052chr3:78685258ENST000004360101929898_918973.33333333333341613.0TransmembraneHelical
TgeneROBO1chr18:12311052chr3:78685258ENST000004642332131898_9181012.33333333333341652.0TransmembraneHelical
TgeneROBO1chr18:12311052chr3:78685258ENST000004952731929898_918967.33333333333341607.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TUBB6
ROBO1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TUBB6-ROBO1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TUBB6-ROBO1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource