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Fusion Protein:TULP4-FNDC1 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: TULP4-FNDC1 | FusionPDB ID: 95468 | FusionGDB2.0 ID: 95468 | Hgene | Tgene | Gene symbol | TULP4 | FNDC1 | Gene ID | 56995 | 84624 |
Gene name | TUB like protein 4 | fibronectin type III domain containing 1 | |
Synonyms | TUSP | AGS8|FNDC2|MEL4B3|bA243O10.1|dJ322A24.1 | |
Cytomap | 6q25.3 | 6q25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | tubby-related protein 4tubby like protein 4tubby super-family proteintubby superfamily protein | fibronectin type III domain-containing protein 1activation-associated cDNA proteinexpressed in synovial lining proteinfibronectin type III domain containing 2 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | Q4ZHG4 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000367094, ENST00000367097, | ENST00000480856, ENST00000297267, ENST00000340366, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 12 X 8 X 9=864 | 4 X 3 X 4=48 |
# samples | 14 | 4 | |
** MAII score | log2(14/864*10)=-2.6256044852185 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: TULP4 [Title/Abstract] AND FNDC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | TULP4(158919844)-FNDC1(159635977), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | TULP4-FNDC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TULP4-FNDC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TULP4-FNDC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TULP4-FNDC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | HNSC | TCGA-UF-A719-01A | TULP4 | chr6 | 158919844 | + | FNDC1 | chr6 | 159635977 | + |
ChimerDB4 | HNSC | TCGA-UF-A719 | TULP4 | chr6 | 158919844 | + | FNDC1 | chr6 | 159635977 | + |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000367094 | TULP4 | chr6 | 158919844 | + | ENST00000340366 | FNDC1 | chr6 | 159635977 | + | 9070 | 3371 | 1357 | 8406 | 2349 |
ENST00000367094 | TULP4 | chr6 | 158919844 | + | ENST00000297267 | FNDC1 | chr6 | 159635977 | + | 9263 | 3371 | 1357 | 8595 | 2412 |
ENST00000367097 | TULP4 | chr6 | 158919844 | + | ENST00000340366 | FNDC1 | chr6 | 159635977 | + | 9070 | 3371 | 1357 | 8406 | 2349 |
ENST00000367097 | TULP4 | chr6 | 158919844 | + | ENST00000297267 | FNDC1 | chr6 | 159635977 | + | 9263 | 3371 | 1357 | 8595 | 2412 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000367094 | ENST00000340366 | TULP4 | chr6 | 158919844 | + | FNDC1 | chr6 | 159635977 | + | 0.002816071 | 0.99718386 |
ENST00000367094 | ENST00000297267 | TULP4 | chr6 | 158919844 | + | FNDC1 | chr6 | 159635977 | + | 0.002880109 | 0.9971199 |
ENST00000367097 | ENST00000340366 | TULP4 | chr6 | 158919844 | + | FNDC1 | chr6 | 159635977 | + | 0.002816071 | 0.99718386 |
ENST00000367097 | ENST00000297267 | TULP4 | chr6 | 158919844 | + | FNDC1 | chr6 | 159635977 | + | 0.002880109 | 0.9971199 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >95468_95468_1_TULP4-FNDC1_TULP4_chr6_158919844_ENST00000367094_FNDC1_chr6_159635977_ENST00000297267_length(amino acids)=2412AA_BP=548 MYAAVEHGPVLCSDSNILCLSWKGRVPKSEKEKPVCRRRYYEEGWLATGNGRGVVGVTFTSSHCRRDRSTPQRINFNLRGHNSEVVLVRW NEPYQKLATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQALISYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQ QVLFGTADGQVIVMDCHGRMLAHVLLHESDGVLGMSWNYPIFLVEDSSESDTDSDDYAPPQDGPAAYPIPVQNIKPLLTVSFTSGDISLM NNYDDLSPTVIRSGLKEVVAQWCTQGDLLAVAGMERQTQLGELPNGPLLKSAMVKFYNVRGEHIFTLDTLVQRPIISICWGHRDSRLLMA SGPALYVVRVEHRVSSLQLLCQQAIASTLREDKDVSKLTLPPRLCSYLSTAFIPTIKPPIPDPNNMRDFVSYPSAGNERLHCTMKRTEDD PEVGGPCYTLYLEYLGGLVPILKGRRISKLRPEFVIMDPRTDSKPDEIYGNSLISTVIDSCNCSDSSDIELSDDWAAKKSPKISRASKSP KLPRISIEARKSPKLPRAAQELSRSPRLPLRKPSVGSPSLTRREFPFEDITQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAVIYKTSL LHLQPRQMTIYLPEVRKISMDYINLPVFNPNVFSEDEDDLPEKEVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESG RKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVV ASRQYTVRYREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASW DALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNGKP EKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQ KRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDER AVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSK GGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSP SRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRK EPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVAT SQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKE AAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGK EDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYT TRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRY LQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPLPT TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAV PTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYVTYLNKDPSAPCSLTDALDHFQVDSLDE IIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKATPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFKVQA QNPHGYGPISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNLKDTFYSIG -------------------------------------------------------------- >95468_95468_2_TULP4-FNDC1_TULP4_chr6_158919844_ENST00000367094_FNDC1_chr6_159635977_ENST00000340366_length(amino acids)=2349AA_BP=548 MYAAVEHGPVLCSDSNILCLSWKGRVPKSEKEKPVCRRRYYEEGWLATGNGRGVVGVTFTSSHCRRDRSTPQRINFNLRGHNSEVVLVRW NEPYQKLATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQALISYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQ QVLFGTADGQVIVMDCHGRMLAHVLLHESDGVLGMSWNYPIFLVEDSSESDTDSDDYAPPQDGPAAYPIPVQNIKPLLTVSFTSGDISLM NNYDDLSPTVIRSGLKEVVAQWCTQGDLLAVAGMERQTQLGELPNGPLLKSAMVKFYNVRGEHIFTLDTLVQRPIISICWGHRDSRLLMA SGPALYVVRVEHRVSSLQLLCQQAIASTLREDKDVSKLTLPPRLCSYLSTAFIPTIKPPIPDPNNMRDFVSYPSAGNERLHCTMKRTEDD PEVGGPCYTLYLEYLGGLVPILKGRRISKLRPEFVIMDPRTDSKPDEIYGNSLISTVIDSCNCSDSSDIELSDDWAAKKSPKISRASKSP KLPRISIEARKSPKLPRAAQELSRSPRLPLRKPSVGSPSLTRREFPFEDITQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAVIYKTSL LHLQPRQMTIYLPEVRKISMDYINLPVFNPNVFSEDEDDLPEKEVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESG RKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVV ASRQYTVRYREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASW DALPETEGKVKASKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDL QSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHAS TQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAP PSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATA QTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVP SSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAAR SQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDA QGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKR PLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRAS HVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQ RIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLV GLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGN LIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYV TYLNKDPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKATPGDVVTGYLVYSASYEDFIRNKW STQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKF VGVVLCNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVRFGNIGFGTPYYYVGWYE -------------------------------------------------------------- >95468_95468_3_TULP4-FNDC1_TULP4_chr6_158919844_ENST00000367097_FNDC1_chr6_159635977_ENST00000297267_length(amino acids)=2412AA_BP=548 MYAAVEHGPVLCSDSNILCLSWKGRVPKSEKEKPVCRRRYYEEGWLATGNGRGVVGVTFTSSHCRRDRSTPQRINFNLRGHNSEVVLVRW NEPYQKLATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQALISYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQ QVLFGTADGQVIVMDCHGRMLAHVLLHESDGVLGMSWNYPIFLVEDSSESDTDSDDYAPPQDGPAAYPIPVQNIKPLLTVSFTSGDISLM NNYDDLSPTVIRSGLKEVVAQWCTQGDLLAVAGMERQTQLGELPNGPLLKSAMVKFYNVRGEHIFTLDTLVQRPIISICWGHRDSRLLMA SGPALYVVRVEHRVSSLQLLCQQAIASTLREDKDVSKLTLPPRLCSYLSTAFIPTIKPPIPDPNNMRDFVSYPSAGNERLHCTMKRTEDD PEVGGPCYTLYLEYLGGLVPILKGRRISKLRPEFVIMDPRTDSKPDEIYGNSLISTVIDSCNCSDSSDIELSDDWAAKKSPKISRASKSP KLPRISIEARKSPKLPRAAQELSRSPRLPLRKPSVGSPSLTRREFPFEDITQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAVIYKTSL LHLQPRQMTIYLPEVRKISMDYINLPVFNPNVFSEDEDDLPEKEVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESG RKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVV ASRQYTVRYREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASW DALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNGKP EKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQ KRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDER AVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPLSK GGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSP SRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLHRK EPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVAT SQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARAKE AAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGK EDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQYT TRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRY LQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPLPT TTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAV PTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYVTYLNKDPSAPCSLTDALDHFQVDSLDE IIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKATPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFKVQA QNPHGYGPISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNLKDTFYSIG -------------------------------------------------------------- >95468_95468_4_TULP4-FNDC1_TULP4_chr6_158919844_ENST00000367097_FNDC1_chr6_159635977_ENST00000340366_length(amino acids)=2349AA_BP=548 MYAAVEHGPVLCSDSNILCLSWKGRVPKSEKEKPVCRRRYYEEGWLATGNGRGVVGVTFTSSHCRRDRSTPQRINFNLRGHNSEVVLVRW NEPYQKLATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQALISYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQ QVLFGTADGQVIVMDCHGRMLAHVLLHESDGVLGMSWNYPIFLVEDSSESDTDSDDYAPPQDGPAAYPIPVQNIKPLLTVSFTSGDISLM NNYDDLSPTVIRSGLKEVVAQWCTQGDLLAVAGMERQTQLGELPNGPLLKSAMVKFYNVRGEHIFTLDTLVQRPIISICWGHRDSRLLMA SGPALYVVRVEHRVSSLQLLCQQAIASTLREDKDVSKLTLPPRLCSYLSTAFIPTIKPPIPDPNNMRDFVSYPSAGNERLHCTMKRTEDD PEVGGPCYTLYLEYLGGLVPILKGRRISKLRPEFVIMDPRTDSKPDEIYGNSLISTVIDSCNCSDSSDIELSDDWAAKKSPKISRASKSP KLPRISIEARKSPKLPRAAQELSRSPRLPLRKPSVGSPSLTRREFPFEDITQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAVIYKTSL LHLQPRQMTIYLPEVRKISMDYINLPVFNPNVFSEDEDDLPEKEVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESG RKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVV ASRQYTVRYREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASW DALPETEGKVKASKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDL QSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHAS TQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAP PSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATA QTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVP SSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAAR SQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDA QGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKR PLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRAS HVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQ RIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLV GLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGN LIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYV TYLNKDPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKATPGDVVTGYLVYSASYEDFIRNKW STQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKF VGVVLCNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVRFGNIGFGTPYYYVGWYE -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:158919844/chr6:159635977) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | FNDC1 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: May be an activator of G protein signaling. {ECO:0000250}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TULP4 | chr6:158919844 | chr6:159635977 | ENST00000367094 | + | 12 | 13 | 364_414 | 671.3333333333334 | 679.0 | Domain | SOCS box |
Hgene | TULP4 | chr6:158919844 | chr6:159635977 | ENST00000367097 | + | 12 | 14 | 364_414 | 671.3333333333334 | 1544.0 | Domain | SOCS box |
Hgene | TULP4 | chr6:158919844 | chr6:159635977 | ENST00000367094 | + | 12 | 13 | 116_158 | 671.3333333333334 | 679.0 | Repeat | Note=WD 3 |
Hgene | TULP4 | chr6:158919844 | chr6:159635977 | ENST00000367094 | + | 12 | 13 | 159_237 | 671.3333333333334 | 679.0 | Repeat | Note=WD 4 |
Hgene | TULP4 | chr6:158919844 | chr6:159635977 | ENST00000367094 | + | 12 | 13 | 238_276 | 671.3333333333334 | 679.0 | Repeat | Note=WD 5 |
Hgene | TULP4 | chr6:158919844 | chr6:159635977 | ENST00000367094 | + | 12 | 13 | 277_334 | 671.3333333333334 | 679.0 | Repeat | Note=WD 6 |
Hgene | TULP4 | chr6:158919844 | chr6:159635977 | ENST00000367094 | + | 12 | 13 | 335_372 | 671.3333333333334 | 679.0 | Repeat | Note=WD 7 |
Hgene | TULP4 | chr6:158919844 | chr6:159635977 | ENST00000367094 | + | 12 | 13 | 6_72 | 671.3333333333334 | 679.0 | Repeat | Note=WD 1 |
Hgene | TULP4 | chr6:158919844 | chr6:159635977 | ENST00000367094 | + | 12 | 13 | 73_115 | 671.3333333333334 | 679.0 | Repeat | Note=WD 2 |
Hgene | TULP4 | chr6:158919844 | chr6:159635977 | ENST00000367097 | + | 12 | 14 | 116_158 | 671.3333333333334 | 1544.0 | Repeat | Note=WD 3 |
Hgene | TULP4 | chr6:158919844 | chr6:159635977 | ENST00000367097 | + | 12 | 14 | 159_237 | 671.3333333333334 | 1544.0 | Repeat | Note=WD 4 |
Hgene | TULP4 | chr6:158919844 | chr6:159635977 | ENST00000367097 | + | 12 | 14 | 238_276 | 671.3333333333334 | 1544.0 | Repeat | Note=WD 5 |
Hgene | TULP4 | chr6:158919844 | chr6:159635977 | ENST00000367097 | + | 12 | 14 | 277_334 | 671.3333333333334 | 1544.0 | Repeat | Note=WD 6 |
Hgene | TULP4 | chr6:158919844 | chr6:159635977 | ENST00000367097 | + | 12 | 14 | 335_372 | 671.3333333333334 | 1544.0 | Repeat | Note=WD 7 |
Hgene | TULP4 | chr6:158919844 | chr6:159635977 | ENST00000367097 | + | 12 | 14 | 6_72 | 671.3333333333334 | 1544.0 | Repeat | Note=WD 1 |
Hgene | TULP4 | chr6:158919844 | chr6:159635977 | ENST00000367097 | + | 12 | 14 | 73_115 | 671.3333333333334 | 1544.0 | Repeat | Note=WD 2 |
Tgene | FNDC1 | chr6:158919844 | chr6:159635977 | ENST00000297267 | 3 | 23 | 1443_1516 | 153.33333333333334 | 1895.0 | Compositional bias | Note=Thr-rich | |
Tgene | FNDC1 | chr6:158919844 | chr6:159635977 | ENST00000297267 | 3 | 23 | 671_773 | 153.33333333333334 | 1895.0 | Compositional bias | Note=Ser-rich | |
Tgene | FNDC1 | chr6:158919844 | chr6:159635977 | ENST00000340366 | 3 | 22 | 1443_1516 | 153.33333333333334 | 1832.0 | Compositional bias | Note=Thr-rich | |
Tgene | FNDC1 | chr6:158919844 | chr6:159635977 | ENST00000340366 | 3 | 22 | 671_773 | 153.33333333333334 | 1832.0 | Compositional bias | Note=Ser-rich | |
Tgene | FNDC1 | chr6:158919844 | chr6:159635977 | ENST00000297267 | 3 | 23 | 158_258 | 153.33333333333334 | 1895.0 | Domain | Fibronectin type-III 2 | |
Tgene | FNDC1 | chr6:158919844 | chr6:159635977 | ENST00000297267 | 3 | 23 | 1658_1752 | 153.33333333333334 | 1895.0 | Domain | Fibronectin type-III 5 | |
Tgene | FNDC1 | chr6:158919844 | chr6:159635977 | ENST00000297267 | 3 | 23 | 262_357 | 153.33333333333334 | 1895.0 | Domain | Fibronectin type-III 3 | |
Tgene | FNDC1 | chr6:158919844 | chr6:159635977 | ENST00000297267 | 3 | 23 | 362_457 | 153.33333333333334 | 1895.0 | Domain | Fibronectin type-III 4 | |
Tgene | FNDC1 | chr6:158919844 | chr6:159635977 | ENST00000340366 | 3 | 22 | 158_258 | 153.33333333333334 | 1832.0 | Domain | Fibronectin type-III 2 | |
Tgene | FNDC1 | chr6:158919844 | chr6:159635977 | ENST00000340366 | 3 | 22 | 1658_1752 | 153.33333333333334 | 1832.0 | Domain | Fibronectin type-III 5 | |
Tgene | FNDC1 | chr6:158919844 | chr6:159635977 | ENST00000340366 | 3 | 22 | 262_357 | 153.33333333333334 | 1832.0 | Domain | Fibronectin type-III 3 | |
Tgene | FNDC1 | chr6:158919844 | chr6:159635977 | ENST00000340366 | 3 | 22 | 362_457 | 153.33333333333334 | 1832.0 | Domain | Fibronectin type-III 4 |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TULP4 | chr6:158919844 | chr6:159635977 | ENST00000367094 | + | 12 | 13 | 1466_1543 | 671.3333333333334 | 679.0 | Region | Note=TUB |
Hgene | TULP4 | chr6:158919844 | chr6:159635977 | ENST00000367097 | + | 12 | 14 | 1466_1543 | 671.3333333333334 | 1544.0 | Region | Note=TUB |
Tgene | FNDC1 | chr6:158919844 | chr6:159635977 | ENST00000297267 | 3 | 23 | 39_131 | 153.33333333333334 | 1895.0 | Domain | Fibronectin type-III 1 | |
Tgene | FNDC1 | chr6:158919844 | chr6:159635977 | ENST00000340366 | 3 | 22 | 39_131 | 153.33333333333334 | 1832.0 | Domain | Fibronectin type-III 1 |
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Fusion Protein Structures |
![]() * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
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pLDDT score distribution |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
TULP4_pLDDT.png![]() |
FNDC1_pLDDT.png![]() |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
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Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
TULP4 | |
FNDC1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to TULP4-FNDC1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to TULP4-FNDC1 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |