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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:TXNDC11-ABCC1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: TXNDC11-ABCC1
FusionPDB ID: 95534
FusionGDB2.0 ID: 95534
HgeneTgene
Gene symbol

TXNDC11

ABCC1

Gene ID

51061

4363

Gene namethioredoxin domain containing 11ATP binding cassette subfamily C member 1
SynonymsEFP1ABC29|ABCC|GS-X|MRP|MRP1
Cytomap

16p13.13

16p13.11

Type of geneprotein-codingprotein-coding
Descriptionthioredoxin domain-containing protein 11EF-hand binding protein 1multidrug resistance-associated protein 1ATP-binding cassette transporter variant ABCC1delta-ex13ATP-binding cassette transporter variant ABCC1delta-ex13&14ATP-binding cassette transporter variant ABCC1delta-ex25ATP-binding cassette transporter varian
Modification date2020031320200313
UniProtAcc.

Q96J66

Ensembl transtripts involved in fusion geneENST idsENST00000283033, ENST00000356957, 
ENST00000570917, 		ENST00000576557, 
ENST00000345148, ENST00000346370, 
ENST00000349029, ENST00000351154, 
ENST00000399408, ENST00000399410, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 9 X 10=108016 X 13 X 5=1040
# samples 1516
** MAII scorelog2(15/1080*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1040*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: TXNDC11 [Title/Abstract] AND ABCC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TXNDC11(11824500)-ABCC1(16101672), # samples:1
Anticipated loss of major functional domain due to fusion event.TXNDC11-ABCC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TXNDC11-ABCC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TXNDC11-ABCC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TXNDC11-ABCC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TXNDC11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABCC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-4257TXNDC11chr16

11824500

-ABCC1chr16

16101672

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000283033TXNDC11chr1611824500-ENST00000399410ABCC1chr1616101672+71768472553941789
ENST00000283033TXNDC11chr1611824500-ENST00000349029ABCC1chr1616101672+68438472550491674
ENST00000283033TXNDC11chr1611824500-ENST00000351154ABCC1chr1616101672+70118472552171730
ENST00000283033TXNDC11chr1611824500-ENST00000399408ABCC1chr1616101672+72188472554241799
ENST00000283033TXNDC11chr1611824500-ENST00000345148ABCC1chr1616101672+69938472551991724
ENST00000283033TXNDC11chr1611824500-ENST00000346370ABCC1chr1616101672+70208472552261733
ENST00000356957TXNDC11chr1611824500-ENST00000399410ABCC1chr1616101672+71368072153541777
ENST00000356957TXNDC11chr1611824500-ENST00000349029ABCC1chr1616101672+68038072150091662
ENST00000356957TXNDC11chr1611824500-ENST00000351154ABCC1chr1616101672+69718072151771718
ENST00000356957TXNDC11chr1611824500-ENST00000399408ABCC1chr1616101672+71788072153841787
ENST00000356957TXNDC11chr1611824500-ENST00000345148ABCC1chr1616101672+69538072151591712
ENST00000356957TXNDC11chr1611824500-ENST00000346370ABCC1chr1616101672+69808072151861721

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000283033ENST00000399410TXNDC11chr1611824500-ABCC1chr1616101672+0.0010352780.99896467
ENST00000283033ENST00000349029TXNDC11chr1611824500-ABCC1chr1616101672+0.0014481380.9985519
ENST00000283033ENST00000351154TXNDC11chr1611824500-ABCC1chr1616101672+0.001429770.9985702
ENST00000283033ENST00000399408TXNDC11chr1611824500-ABCC1chr1616101672+0.0007071070.99929285
ENST00000283033ENST00000345148TXNDC11chr1611824500-ABCC1chr1616101672+0.0011338320.9988662
ENST00000283033ENST00000346370TXNDC11chr1611824500-ABCC1chr1616101672+0.0013420130.99865794
ENST00000356957ENST00000399410TXNDC11chr1611824500-ABCC1chr1616101672+0.0009934620.99900657
ENST00000356957ENST00000349029TXNDC11chr1611824500-ABCC1chr1616101672+0.0013974190.99860257
ENST00000356957ENST00000351154TXNDC11chr1611824500-ABCC1chr1616101672+0.0013807230.9986193
ENST00000356957ENST00000399408TXNDC11chr1611824500-ABCC1chr1616101672+0.0006779510.99932206
ENST00000356957ENST00000345148TXNDC11chr1611824500-ABCC1chr1616101672+0.001089390.99891067
ENST00000356957ENST00000346370TXNDC11chr1611824500-ABCC1chr1616101672+0.0012931640.9987068

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>95534_95534_1_TXNDC11-ABCC1_TXNDC11_chr16_11824500_ENST00000283033_ABCC1_chr16_16101672_ENST00000345148_length(amino acids)=1724AA_BP=274
MTWSVRVSGCGELRDWGATGRAGPSGPRRRRRYKAGDWEHVMSECGGRGGGSSSSEDAEDEGGGGGGPAGSDCLSSSPTLATASSAGRLR
RGLRGAFLMARQRPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFSLRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQ
SIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFL
SNYEDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFL
APVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFS
DRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDP
AQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFV
TACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNL
GPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFT
WVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTN
SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQL
EEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTR
ILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQR
QLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDD
PIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIK
MFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKV
DENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEK
EAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIG
LHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRVIVLDKGEIQEYGAPSDLLQQ

--------------------------------------------------------------

>95534_95534_2_TXNDC11-ABCC1_TXNDC11_chr16_11824500_ENST00000283033_ABCC1_chr16_16101672_ENST00000346370_length(amino acids)=1733AA_BP=274
MTWSVRVSGCGELRDWGATGRAGPSGPRRRRRYKAGDWEHVMSECGGRGGGSSSSEDAEDEGGGGGGPAGSDCLSSSPTLATASSAGRLR
RGLRGAFLMARQRPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFSLRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQ
SIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFL
SNYEDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFL
APVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFS
DRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDP
AQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFV
TACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNL
GPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFT
WVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTN
SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQL
EEPYYRSVIQACALLPDLEILPSGDRTEIGEKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDA
EENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMK
AIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILR
SPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSR
SPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSL
QVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGR
TGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDK
LDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEY

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>95534_95534_3_TXNDC11-ABCC1_TXNDC11_chr16_11824500_ENST00000283033_ABCC1_chr16_16101672_ENST00000349029_length(amino acids)=1674AA_BP=274
MTWSVRVSGCGELRDWGATGRAGPSGPRRRRRYKAGDWEHVMSECGGRGGGSSSSEDAEDEGGGGGGPAGSDCLSSSPTLATASSAGRLR
RGLRGAFLMARQRPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFSLRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQ
SIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFL
SNYEDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFL
APVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFS
DRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDP
AQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFV
TACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNL
GPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFT
WVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTN
SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQVDVIIVMSGGKIS
EMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKA
EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQG
IAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAI
IIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVG
NCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRN
YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMN
LDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE

--------------------------------------------------------------

>95534_95534_4_TXNDC11-ABCC1_TXNDC11_chr16_11824500_ENST00000283033_ABCC1_chr16_16101672_ENST00000351154_length(amino acids)=1730AA_BP=274
MTWSVRVSGCGELRDWGATGRAGPSGPRRRRRYKAGDWEHVMSECGGRGGGSSSSEDAEDEGGGGGGPAGSDCLSSSPTLATASSAGRLR
RGLRGAFLMARQRPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFSLRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQ
SIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFL
SNYEDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFL
APVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFS
DRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDP
AQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFV
TACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNL
GPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFT
WVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTN
SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLF
DDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEEN
GVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIG
LFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPM
SFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPV
YSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVT
TYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGA
GKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDH
ECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAP

--------------------------------------------------------------

>95534_95534_5_TXNDC11-ABCC1_TXNDC11_chr16_11824500_ENST00000283033_ABCC1_chr16_16101672_ENST00000399408_length(amino acids)=1799AA_BP=274
MTWSVRVSGCGELRDWGATGRAGPSGPRRRRRYKAGDWEHVMSECGGRGGGSSSSEDAEDEGGGGGGPAGSDCLSSSPTLATASSAGRLR
RGLRGAFLMARQRPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFSLRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQ
SIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFL
SNYEDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFL
APVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFS
DRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDP
AQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFV
TACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNL
GPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFT
WVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTN
SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQL
EEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTR
ILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGSTVMDEEEAGVTGVSGPGKEAKQMENGMLV
TDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALAS
NYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDT
VDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQE
RFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVE
RLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEII
IDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLAR

--------------------------------------------------------------

>95534_95534_6_TXNDC11-ABCC1_TXNDC11_chr16_11824500_ENST00000283033_ABCC1_chr16_16101672_ENST00000399410_length(amino acids)=1789AA_BP=274
MTWSVRVSGCGELRDWGATGRAGPSGPRRRRRYKAGDWEHVMSECGGRGGGSSSSEDAEDEGGGGGGPAGSDCLSSSPTLATASSAGRLR
RGLRGAFLMARQRPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFSLRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQ
SIAARAEIEQAASRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFL
SNYEDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFL
APVFLVSPTLLGITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFS
DRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDP
AQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFV
TACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNL
GPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFT
WVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTN
SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQL
EEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTR
ILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQR
QLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDD
PIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIK
MFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKV
DENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEK
EAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIG
LHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILV

--------------------------------------------------------------

>95534_95534_7_TXNDC11-ABCC1_TXNDC11_chr16_11824500_ENST00000356957_ABCC1_chr16_16101672_ENST00000345148_length(amino acids)=1712AA_BP=262
MRDWGATGRAGPSGPRRRRRYKAGDWEHVMSECGGRGGGSSSSEDAEDEGGGGGGPAGSDCLSSSPTLATASSAGRLRRGLRGAFLMARQ
RPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFSLRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQSIAARAEIEQAA
SRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFLSNYEDWNVTWNT
SNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLG
ITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHD
PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDAN
EEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY
FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMV
LMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT
FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWA
RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQAC
ALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQ
VDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDI
SRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKV
RLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGA
CIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIV
ANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPP
SSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIP
QDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAG

--------------------------------------------------------------

>95534_95534_8_TXNDC11-ABCC1_TXNDC11_chr16_11824500_ENST00000356957_ABCC1_chr16_16101672_ENST00000346370_length(amino acids)=1721AA_BP=262
MRDWGATGRAGPSGPRRRRRYKAGDWEHVMSECGGRGGGSSSSEDAEDEGGGGGGPAGSDCLSSSPTLATASSAGRLRRGLRGAFLMARQ
RPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFSLRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQSIAARAEIEQAA
SRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFLSNYEDWNVTWNT
SNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLG
ITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHD
PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDAN
EEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY
FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMV
LMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT
FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWA
RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQAC
ALLPDLEILPSGDRTEIGEKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPG
KEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIF
LFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSG
NLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLL
GVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRM
SSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGL
FRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL
SVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGL

--------------------------------------------------------------

>95534_95534_9_TXNDC11-ABCC1_TXNDC11_chr16_11824500_ENST00000356957_ABCC1_chr16_16101672_ENST00000349029_length(amino acids)=1662AA_BP=262
MRDWGATGRAGPSGPRRRRRYKAGDWEHVMSECGGRGGGSSSSEDAEDEGGGGGGPAGSDCLSSSPTLATASSAGRLRRGLRGAFLMARQ
RPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFSLRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQSIAARAEIEQAA
SRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFLSNYEDWNVTWNT
SNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLG
ITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHD
PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDAN
EEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY
FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMV
LMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT
FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWA
RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARD
GAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLME
ADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSI
GGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFV
QRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAV
ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFV
LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEV
WTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLN

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>95534_95534_10_TXNDC11-ABCC1_TXNDC11_chr16_11824500_ENST00000356957_ABCC1_chr16_16101672_ENST00000351154_length(amino acids)=1718AA_BP=262
MRDWGATGRAGPSGPRRRRRYKAGDWEHVMSECGGRGGGSSSSEDAEDEGGGGGGPAGSDCLSSSPTLATASSAGRLRRGLRGAFLMARQ
RPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFSLRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQSIAARAEIEQAA
SRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFLSNYEDWNVTWNT
SNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLG
ITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHD
PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDAN
EEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY
FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMV
LMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT
FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWA
RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVG
KHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEA
KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFM
CNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLV
NRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVS
VIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSE
METNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRI
NESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVG
QRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYS

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>95534_95534_11_TXNDC11-ABCC1_TXNDC11_chr16_11824500_ENST00000356957_ABCC1_chr16_16101672_ENST00000399408_length(amino acids)=1787AA_BP=262
MRDWGATGRAGPSGPRRRRRYKAGDWEHVMSECGGRGGGSSSSEDAEDEGGGGGGPAGSDCLSSSPTLATASSAGRLRRGLRGAFLMARQ
RPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFSLRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQSIAARAEIEQAA
SRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFLSNYEDWNVTWNT
SNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLG
ITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHD
PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDAN
EEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY
FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMV
LMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT
FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWA
RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQAC
ALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQ
VDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGSTVMDEEEAGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQL
SSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPI
VNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMF
MGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDE
NQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEA
PWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLH
DLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLD

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>95534_95534_12_TXNDC11-ABCC1_TXNDC11_chr16_11824500_ENST00000356957_ABCC1_chr16_16101672_ENST00000399410_length(amino acids)=1777AA_BP=262
MRDWGATGRAGPSGPRRRRRYKAGDWEHVMSECGGRGGGSSSSEDAEDEGGGGGGPAGSDCLSSSPTLATASSAGRLRRGLRGAFLMARQ
RPELLCGAVALGCALLLALKFTCSRAKDVIIPAKPPVSFFSLRSPVLDLFQGQLDYAEYVRRDSEVVLLFFYAPWCGQSIAARAEIEQAA
SRLSDQVLFVAINCWWNQGKCRKQKHFFYFPVIYLYHRSFGPIEYKGPMSAVYIEKFVRRVMKPLLYIPSQSELLDFLSNYEDWNVTWNT
SNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLG
ITMLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHD
PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDAN
EEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY
FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMV
LMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT
FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWA
RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQAC
ALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQ
VDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDI
SRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKV
RLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGA
CIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIV
ANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPP
SSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIP
QDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLET

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:11824500/chr16:16101672)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ABCC1

Q96J66

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides (PubMed:12764137, PubMed:15537867). Stimulates the ATP-dependent uptake of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate (PubMed:15537867, PubMed:25896536). Enhances also the cellular extrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867). Confers resistance to anticancer drugs, such as 5-fluorouracil (5-FU) and methotrexate (PubMed:25896536, PubMed:15537867, PubMed:12764137). Probably functions to secrete earwax (PubMed:16444273, PubMed:19383836). Required for the secretion of components contributing to axillary odor formation (PubMed:19710689, PubMed:12764137, PubMed:15537867, PubMed:16444273, PubMed:19383836, PubMed:25896536). {ECO:0000269|PubMed:12764137, ECO:0000269|PubMed:15537867, ECO:0000269|PubMed:16444273, ECO:0000269|PubMed:19383836, ECO:0000269|PubMed:19710689, ECO:0000269|PubMed:25896536}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTXNDC11chr16:11824500chr16:16101672ENST00000283033-41292_214233.0959.0DomainThioredoxin 1
HgeneTXNDC11chr16:11824500chr16:16101672ENST00000356957-41392_214233.0986.0DomainThioredoxin 1
HgeneTXNDC11chr16:11824500chr16:16101672ENST00000283033-41265_85233.0959.0TransmembraneHelical
HgeneTXNDC11chr16:11824500chr16:16101672ENST00000356957-41365_85233.0986.0TransmembraneHelical
TgeneABCC1chr16:11824500chr16:16101672ENST000003451480301293_152716.01467.0DomainABC transporter 2
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030325_60816.01467.0DomainABC transmembrane type-1 1
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030644_86816.01467.0DomainABC transporter 1
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030975_125616.01467.0DomainABC transmembrane type-1 2
TgeneABCC1chr16:11824500chr16:16101672ENST000003463700301293_152716.01476.0DomainABC transporter 2
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030325_60816.01476.0DomainABC transmembrane type-1 1
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030644_86816.01476.0DomainABC transporter 1
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030975_125616.01476.0DomainABC transmembrane type-1 2
TgeneABCC1chr16:11824500chr16:16101672ENST000003490290291293_152716.01417.0DomainABC transporter 2
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029325_60816.01417.0DomainABC transmembrane type-1 1
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029644_86816.01417.0DomainABC transporter 1
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029975_125616.01417.0DomainABC transmembrane type-1 2
TgeneABCC1chr16:11824500chr16:16101672ENST000003511540301293_152716.01473.0DomainABC transporter 2
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030325_60816.01473.0DomainABC transmembrane type-1 1
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030644_86816.01473.0DomainABC transporter 1
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030975_125616.01473.0DomainABC transmembrane type-1 2
TgeneABCC1chr16:11824500chr16:16101672ENST000003994080321293_152716.01542.0DomainABC transporter 2
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032325_60816.01542.0DomainABC transmembrane type-1 1
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032644_86816.01542.0DomainABC transporter 1
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032975_125616.01542.0DomainABC transmembrane type-1 2
TgeneABCC1chr16:11824500chr16:16101672ENST000003994100311293_152716.01532.0DomainABC transporter 2
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031325_60816.01532.0DomainABC transmembrane type-1 1
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031644_86816.01532.0DomainABC transporter 1
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031975_125616.01532.0DomainABC transmembrane type-1 2
TgeneABCC1chr16:11824500chr16:16101672ENST000003451480301327_133416.01467.0Nucleotide bindingATP 2
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030678_68516.01467.0Nucleotide bindingNote=ATP 1
TgeneABCC1chr16:11824500chr16:16101672ENST000003463700301327_133416.01476.0Nucleotide bindingATP 2
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030678_68516.01476.0Nucleotide bindingNote=ATP 1
TgeneABCC1chr16:11824500chr16:16101672ENST000003490290291327_133416.01417.0Nucleotide bindingATP 2
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029678_68516.01417.0Nucleotide bindingNote=ATP 1
TgeneABCC1chr16:11824500chr16:16101672ENST000003511540301327_133416.01473.0Nucleotide bindingATP 2
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030678_68516.01473.0Nucleotide bindingNote=ATP 1
TgeneABCC1chr16:11824500chr16:16101672ENST000003994080321327_133416.01542.0Nucleotide bindingATP 2
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032678_68516.01542.0Nucleotide bindingNote=ATP 1
TgeneABCC1chr16:11824500chr16:16101672ENST000003994100311327_133416.01532.0Nucleotide bindingATP 2
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031678_68516.01532.0Nucleotide bindingNote=ATP 1
TgeneABCC1chr16:11824500chr16:16101672ENST000003451480301047_108916.01467.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST000003451480301111_111116.01467.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST000003451480301133_120316.01467.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST000003451480301225_122616.01467.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030122_13316.01467.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST000003451480301248_153116.01467.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030155_17216.01467.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030194_31616.01467.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030338_36316.01467.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030385_44016.01467.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030462_46416.01467.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030486_54716.01467.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST0000034514803055_7416.01467.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030569_59016.01467.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030612_96716.01467.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST0000034514803096_10016.01467.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030989_102516.01467.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST000003463700301047_108916.01476.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST000003463700301111_111116.01476.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST000003463700301133_120316.01476.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST000003463700301225_122616.01476.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030122_13316.01476.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST000003463700301248_153116.01476.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030155_17216.01476.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030194_31616.01476.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030338_36316.01476.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030385_44016.01476.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030462_46416.01476.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030486_54716.01476.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST0000034637003055_7416.01476.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030569_59016.01476.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030612_96716.01476.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST0000034637003096_10016.01476.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030989_102516.01476.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST000003490290291047_108916.01417.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST000003490290291111_111116.01417.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST000003490290291133_120316.01417.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST000003490290291225_122616.01417.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029122_13316.01417.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST000003490290291248_153116.01417.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029155_17216.01417.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029194_31616.01417.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029338_36316.01417.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029385_44016.01417.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029462_46416.01417.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029486_54716.01417.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST0000034902902955_7416.01417.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029569_59016.01417.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029612_96716.01417.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST0000034902902996_10016.01417.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029989_102516.01417.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST000003511540301047_108916.01473.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST000003511540301111_111116.01473.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST000003511540301133_120316.01473.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST000003511540301225_122616.01473.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030122_13316.01473.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST000003511540301248_153116.01473.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030155_17216.01473.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030194_31616.01473.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030338_36316.01473.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030385_44016.01473.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030462_46416.01473.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030486_54716.01473.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST0000035115403055_7416.01473.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030569_59016.01473.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030612_96716.01473.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST0000035115403096_10016.01473.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030989_102516.01473.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST000003994080321047_108916.01542.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST000003994080321111_111116.01542.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST000003994080321133_120316.01542.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST000003994080321225_122616.01542.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032122_13316.01542.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST000003994080321248_153116.01542.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032155_17216.01542.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032194_31616.01542.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032338_36316.01542.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032385_44016.01542.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032462_46416.01542.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032486_54716.01542.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST0000039940803255_7416.01542.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032569_59016.01542.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032612_96716.01542.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST0000039940803296_10016.01542.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032989_102516.01542.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST000003994100311047_108916.01532.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST000003994100311111_111116.01532.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST000003994100311133_120316.01532.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST000003994100311225_122616.01532.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031122_13316.01532.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST000003994100311248_153116.01532.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031155_17216.01532.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031194_31616.01532.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031338_36316.01532.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031385_44016.01532.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031462_46416.01532.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031486_54716.01532.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST0000039941003155_7416.01532.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031569_59016.01532.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031612_96716.01532.0Topological domainNote=Cytoplasmic
TgeneABCC1chr16:11824500chr16:16101672ENST0000039941003196_10016.01532.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031989_102516.01532.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030101_12116.01467.0TransmembraneNote=Helical%3B Name%3D3
TgeneABCC1chr16:11824500chr16:16101672ENST000003451480301026_104616.01467.0TransmembraneNote=Helical%3B Name%3D13
TgeneABCC1chr16:11824500chr16:16101672ENST000003451480301090_111016.01467.0TransmembraneNote=Helical%3B Name%3D14
TgeneABCC1chr16:11824500chr16:16101672ENST000003451480301112_113216.01467.0TransmembraneNote=Helical%3B Name%3D15
TgeneABCC1chr16:11824500chr16:16101672ENST000003451480301204_122416.01467.0TransmembraneNote=Helical%3B Name%3D16
TgeneABCC1chr16:11824500chr16:16101672ENST000003451480301227_124716.01467.0TransmembraneNote=Helical%3B Name%3D17
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030134_15416.01467.0TransmembraneNote=Helical%3B Name%3D4
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030173_19316.01467.0TransmembraneNote=Helical%3B Name%3D5
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030317_33716.01467.0TransmembraneNote=Helical%3B Name%3D6
TgeneABCC1chr16:11824500chr16:16101672ENST0000034514803034_5416.01467.0TransmembraneNote=Helical%3B Name%3D1
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030364_38416.01467.0TransmembraneNote=Helical%3B Name%3D7
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030441_46116.01467.0TransmembraneNote=Helical%3B Name%3D8
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030465_48516.01467.0TransmembraneNote=Helical%3B Name%3D9
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030548_56816.01467.0TransmembraneNote=Helical%3B Name%3D10
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030591_61116.01467.0TransmembraneNote=Helical%3B Name%3D11
TgeneABCC1chr16:11824500chr16:16101672ENST0000034514803075_9516.01467.0TransmembraneNote=Helical%3B Name%3D2
TgeneABCC1chr16:11824500chr16:16101672ENST00000345148030968_98816.01467.0TransmembraneNote=Helical%3B Name%3D12
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030101_12116.01476.0TransmembraneNote=Helical%3B Name%3D3
TgeneABCC1chr16:11824500chr16:16101672ENST000003463700301026_104616.01476.0TransmembraneNote=Helical%3B Name%3D13
TgeneABCC1chr16:11824500chr16:16101672ENST000003463700301090_111016.01476.0TransmembraneNote=Helical%3B Name%3D14
TgeneABCC1chr16:11824500chr16:16101672ENST000003463700301112_113216.01476.0TransmembraneNote=Helical%3B Name%3D15
TgeneABCC1chr16:11824500chr16:16101672ENST000003463700301204_122416.01476.0TransmembraneNote=Helical%3B Name%3D16
TgeneABCC1chr16:11824500chr16:16101672ENST000003463700301227_124716.01476.0TransmembraneNote=Helical%3B Name%3D17
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030134_15416.01476.0TransmembraneNote=Helical%3B Name%3D4
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030173_19316.01476.0TransmembraneNote=Helical%3B Name%3D5
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030317_33716.01476.0TransmembraneNote=Helical%3B Name%3D6
TgeneABCC1chr16:11824500chr16:16101672ENST0000034637003034_5416.01476.0TransmembraneNote=Helical%3B Name%3D1
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030364_38416.01476.0TransmembraneNote=Helical%3B Name%3D7
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030441_46116.01476.0TransmembraneNote=Helical%3B Name%3D8
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030465_48516.01476.0TransmembraneNote=Helical%3B Name%3D9
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030548_56816.01476.0TransmembraneNote=Helical%3B Name%3D10
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030591_61116.01476.0TransmembraneNote=Helical%3B Name%3D11
TgeneABCC1chr16:11824500chr16:16101672ENST0000034637003075_9516.01476.0TransmembraneNote=Helical%3B Name%3D2
TgeneABCC1chr16:11824500chr16:16101672ENST00000346370030968_98816.01476.0TransmembraneNote=Helical%3B Name%3D12
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029101_12116.01417.0TransmembraneNote=Helical%3B Name%3D3
TgeneABCC1chr16:11824500chr16:16101672ENST000003490290291026_104616.01417.0TransmembraneNote=Helical%3B Name%3D13
TgeneABCC1chr16:11824500chr16:16101672ENST000003490290291090_111016.01417.0TransmembraneNote=Helical%3B Name%3D14
TgeneABCC1chr16:11824500chr16:16101672ENST000003490290291112_113216.01417.0TransmembraneNote=Helical%3B Name%3D15
TgeneABCC1chr16:11824500chr16:16101672ENST000003490290291204_122416.01417.0TransmembraneNote=Helical%3B Name%3D16
TgeneABCC1chr16:11824500chr16:16101672ENST000003490290291227_124716.01417.0TransmembraneNote=Helical%3B Name%3D17
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029134_15416.01417.0TransmembraneNote=Helical%3B Name%3D4
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029173_19316.01417.0TransmembraneNote=Helical%3B Name%3D5
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029317_33716.01417.0TransmembraneNote=Helical%3B Name%3D6
TgeneABCC1chr16:11824500chr16:16101672ENST0000034902902934_5416.01417.0TransmembraneNote=Helical%3B Name%3D1
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029364_38416.01417.0TransmembraneNote=Helical%3B Name%3D7
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029441_46116.01417.0TransmembraneNote=Helical%3B Name%3D8
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029465_48516.01417.0TransmembraneNote=Helical%3B Name%3D9
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029548_56816.01417.0TransmembraneNote=Helical%3B Name%3D10
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029591_61116.01417.0TransmembraneNote=Helical%3B Name%3D11
TgeneABCC1chr16:11824500chr16:16101672ENST0000034902902975_9516.01417.0TransmembraneNote=Helical%3B Name%3D2
TgeneABCC1chr16:11824500chr16:16101672ENST00000349029029968_98816.01417.0TransmembraneNote=Helical%3B Name%3D12
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030101_12116.01473.0TransmembraneNote=Helical%3B Name%3D3
TgeneABCC1chr16:11824500chr16:16101672ENST000003511540301026_104616.01473.0TransmembraneNote=Helical%3B Name%3D13
TgeneABCC1chr16:11824500chr16:16101672ENST000003511540301090_111016.01473.0TransmembraneNote=Helical%3B Name%3D14
TgeneABCC1chr16:11824500chr16:16101672ENST000003511540301112_113216.01473.0TransmembraneNote=Helical%3B Name%3D15
TgeneABCC1chr16:11824500chr16:16101672ENST000003511540301204_122416.01473.0TransmembraneNote=Helical%3B Name%3D16
TgeneABCC1chr16:11824500chr16:16101672ENST000003511540301227_124716.01473.0TransmembraneNote=Helical%3B Name%3D17
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030134_15416.01473.0TransmembraneNote=Helical%3B Name%3D4
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030173_19316.01473.0TransmembraneNote=Helical%3B Name%3D5
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030317_33716.01473.0TransmembraneNote=Helical%3B Name%3D6
TgeneABCC1chr16:11824500chr16:16101672ENST0000035115403034_5416.01473.0TransmembraneNote=Helical%3B Name%3D1
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030364_38416.01473.0TransmembraneNote=Helical%3B Name%3D7
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030441_46116.01473.0TransmembraneNote=Helical%3B Name%3D8
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030465_48516.01473.0TransmembraneNote=Helical%3B Name%3D9
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030548_56816.01473.0TransmembraneNote=Helical%3B Name%3D10
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030591_61116.01473.0TransmembraneNote=Helical%3B Name%3D11
TgeneABCC1chr16:11824500chr16:16101672ENST0000035115403075_9516.01473.0TransmembraneNote=Helical%3B Name%3D2
TgeneABCC1chr16:11824500chr16:16101672ENST00000351154030968_98816.01473.0TransmembraneNote=Helical%3B Name%3D12
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032101_12116.01542.0TransmembraneNote=Helical%3B Name%3D3
TgeneABCC1chr16:11824500chr16:16101672ENST000003994080321026_104616.01542.0TransmembraneNote=Helical%3B Name%3D13
TgeneABCC1chr16:11824500chr16:16101672ENST000003994080321090_111016.01542.0TransmembraneNote=Helical%3B Name%3D14
TgeneABCC1chr16:11824500chr16:16101672ENST000003994080321112_113216.01542.0TransmembraneNote=Helical%3B Name%3D15
TgeneABCC1chr16:11824500chr16:16101672ENST000003994080321204_122416.01542.0TransmembraneNote=Helical%3B Name%3D16
TgeneABCC1chr16:11824500chr16:16101672ENST000003994080321227_124716.01542.0TransmembraneNote=Helical%3B Name%3D17
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032134_15416.01542.0TransmembraneNote=Helical%3B Name%3D4
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032173_19316.01542.0TransmembraneNote=Helical%3B Name%3D5
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032317_33716.01542.0TransmembraneNote=Helical%3B Name%3D6
TgeneABCC1chr16:11824500chr16:16101672ENST0000039940803234_5416.01542.0TransmembraneNote=Helical%3B Name%3D1
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032364_38416.01542.0TransmembraneNote=Helical%3B Name%3D7
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032441_46116.01542.0TransmembraneNote=Helical%3B Name%3D8
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032465_48516.01542.0TransmembraneNote=Helical%3B Name%3D9
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032548_56816.01542.0TransmembraneNote=Helical%3B Name%3D10
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032591_61116.01542.0TransmembraneNote=Helical%3B Name%3D11
TgeneABCC1chr16:11824500chr16:16101672ENST0000039940803275_9516.01542.0TransmembraneNote=Helical%3B Name%3D2
TgeneABCC1chr16:11824500chr16:16101672ENST00000399408032968_98816.01542.0TransmembraneNote=Helical%3B Name%3D12
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031101_12116.01532.0TransmembraneNote=Helical%3B Name%3D3
TgeneABCC1chr16:11824500chr16:16101672ENST000003994100311026_104616.01532.0TransmembraneNote=Helical%3B Name%3D13
TgeneABCC1chr16:11824500chr16:16101672ENST000003994100311090_111016.01532.0TransmembraneNote=Helical%3B Name%3D14
TgeneABCC1chr16:11824500chr16:16101672ENST000003994100311112_113216.01532.0TransmembraneNote=Helical%3B Name%3D15
TgeneABCC1chr16:11824500chr16:16101672ENST000003994100311204_122416.01532.0TransmembraneNote=Helical%3B Name%3D16
TgeneABCC1chr16:11824500chr16:16101672ENST000003994100311227_124716.01532.0TransmembraneNote=Helical%3B Name%3D17
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031134_15416.01532.0TransmembraneNote=Helical%3B Name%3D4
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031173_19316.01532.0TransmembraneNote=Helical%3B Name%3D5
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031317_33716.01532.0TransmembraneNote=Helical%3B Name%3D6
TgeneABCC1chr16:11824500chr16:16101672ENST0000039941003134_5416.01532.0TransmembraneNote=Helical%3B Name%3D1
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031364_38416.01532.0TransmembraneNote=Helical%3B Name%3D7
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031441_46116.01532.0TransmembraneNote=Helical%3B Name%3D8
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031465_48516.01532.0TransmembraneNote=Helical%3B Name%3D9
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031548_56816.01532.0TransmembraneNote=Helical%3B Name%3D10
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031591_61116.01532.0TransmembraneNote=Helical%3B Name%3D11
TgeneABCC1chr16:11824500chr16:16101672ENST0000039941003175_9516.01532.0TransmembraneNote=Helical%3B Name%3D2
TgeneABCC1chr16:11824500chr16:16101672ENST00000399410031968_98816.01532.0TransmembraneNote=Helical%3B Name%3D12

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTXNDC11chr16:11824500chr16:16101672ENST00000283033-412821_919233.0959.0Coiled coilOntology_term=ECO:0000255
HgeneTXNDC11chr16:11824500chr16:16101672ENST00000356957-413821_919233.0986.0Coiled coilOntology_term=ECO:0000255
HgeneTXNDC11chr16:11824500chr16:16101672ENST00000283033-412649_799233.0959.0DomainThioredoxin 2
HgeneTXNDC11chr16:11824500chr16:16101672ENST00000356957-413649_799233.0986.0DomainThioredoxin 2
TgeneABCC1chr16:11824500chr16:16101672ENST000003451480301_3316.01467.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST000003463700301_3316.01476.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST000003490290291_3316.01417.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST000003511540301_3316.01473.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST000003994080321_3316.01542.0Topological domainNote=Extracellular
TgeneABCC1chr16:11824500chr16:16101672ENST000003994100311_3316.01532.0Topological domainNote=Extracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
TXNDC11
ABCC1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to TXNDC11-ABCC1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to TXNDC11-ABCC1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource