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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:TYK2-KEAP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: TYK2-KEAP1
	FusionPDB ID: 95651
	FusionGDB2.0 ID: 95651
		Hgene	Tgene
	Gene symbol	TYK2	KEAP1
	Gene ID	7297	9817
	Gene name	tyrosine kinase 2	kelch like ECH associated protein 1
	Synonyms	IMD35\|JTK1	INrf2\|KLHL19
	Cytomap	19p13.2	19p13.2
	Type of gene	protein-coding	protein-coding
	Description	non-receptor tyrosine-protein kinase TYK2	kelch-like ECH-associated protein 1KEAP1 delta Ccytosolic inhibitor of Nrf2kelch-like family member 19kelch-like protein 19
	Modification date	20200329	20200327
	UniProtAcc	.	Q14145
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000264818, ENST00000524462, ENST00000525621, ENST00000529370, ENST00000529422,	ENST00000588024, ENST00000171111, ENST00000393623,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 11 X 8=1144	6 X 5 X 5=150
	# samples	15	8
	** MAII score	log2(15/1144*10)=-2.93105264628251 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/150*10)=-0.906890595608519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: TYK2 [Title/Abstract] AND KEAP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	TYK2(10490291)-KEAP1(10610756), # samples:2
Anticipated loss of major functional domain due to fusion event.	TYK2-KEAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TYK2-KEAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	KEAP1	GO:0006511	ubiquitin-dependent protein catabolic process	15601839
Tgene	KEAP1	GO:0010506	regulation of autophagy	20452972
Tgene	KEAP1	GO:0016567	protein ubiquitination	15601839\|15983046
Tgene	KEAP1	GO:0034599	cellular response to oxidative stress	15601839

Fusion gene breakpoints across TYK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KEAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-77-A5GH	TYK2	chr19	10476192	-	KEAP1	chr19	10602938	-
ChimerDB4	STAD	TCGA-CD-5800-01A	TYK2	chr19	10490291	-	KEAP1	chr19	10610756	-
ChimerDB4	STAD	TCGA-CD-5800	TYK2	chr19	10490290	-	KEAP1	chr19	10610756	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264818	TYK2	chr19	10476192	-	ENST00000171111	KEAP1	chr19	10602938	-	2779	1011	0	2246	748
ENST00000264818	TYK2	chr19	10476192	-	ENST00000393623	KEAP1	chr19	10602938	-	2773	1011	0	2246	748
ENST00000524462	TYK2	chr19	10476192	-	ENST00000171111	KEAP1	chr19	10602938	-	2370	602	38	1837	599
ENST00000524462	TYK2	chr19	10476192	-	ENST00000393623	KEAP1	chr19	10602938	-	2364	602	38	1837	599
ENST00000525621	TYK2	chr19	10476192	-	ENST00000171111	KEAP1	chr19	10602938	-	3261	1493	482	2728	748
ENST00000525621	TYK2	chr19	10476192	-	ENST00000393623	KEAP1	chr19	10602938	-	3255	1493	482	2728	748
ENST00000529370	TYK2	chr19	10476192	-	ENST00000171111	KEAP1	chr19	10602938	-	3110	1342	331	2577	748
ENST00000529370	TYK2	chr19	10476192	-	ENST00000393623	KEAP1	chr19	10602938	-	3104	1342	331	2577	748

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264818	ENST00000171111	TYK2	chr19	10476192	-	KEAP1	chr19	10602938	-	0.007327702	0.9926723
ENST00000264818	ENST00000393623	TYK2	chr19	10476192	-	KEAP1	chr19	10602938	-	0.00734379	0.99265623
ENST00000524462	ENST00000171111	TYK2	chr19	10476192	-	KEAP1	chr19	10602938	-	0.005444741	0.99455523
ENST00000524462	ENST00000393623	TYK2	chr19	10476192	-	KEAP1	chr19	10602938	-	0.005435188	0.9945648
ENST00000525621	ENST00000171111	TYK2	chr19	10476192	-	KEAP1	chr19	10602938	-	0.008322332	0.99167764
ENST00000525621	ENST00000393623	TYK2	chr19	10476192	-	KEAP1	chr19	10602938	-	0.008357569	0.9916425
ENST00000529370	ENST00000171111	TYK2	chr19	10476192	-	KEAP1	chr19	10602938	-	0.007759729	0.9922403
ENST00000529370	ENST00000393623	TYK2	chr19	10476192	-	KEAP1	chr19	10602938	-	0.007793255	0.99220675

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>95651_95651_1_TYK2-KEAP1_TYK2_chr19_10476192_ENST00000264818_KEAP1_chr19_10602938_ENST00000171111_length(amino acids)=748AA_BP=337
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHI
LEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRF
GTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEVAKQEEFFNLSHCQLVTLISRDD
LNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGR
LIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRI
GVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTI
RSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTR

--------------------------------------------------------------

>95651_95651_2_TYK2-KEAP1_TYK2_chr19_10476192_ENST00000264818_KEAP1_chr19_10602938_ENST00000393623_length(amino acids)=748AA_BP=337
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHI
LEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRF
GTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEVAKQEEFFNLSHCQLVTLISRDD
LNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGR
LIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRI
GVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTI
RSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTR

--------------------------------------------------------------

>95651_95651_3_TYK2-KEAP1_TYK2_chr19_10476192_ENST00000524462_KEAP1_chr19_10602938_ENST00000171111_length(amino acids)=599AA_BP=188
MCSPGRGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFR
RFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPV
EEEVNKEEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDS
RCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPD
GNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAV
GGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGR

--------------------------------------------------------------

>95651_95651_4_TYK2-KEAP1_TYK2_chr19_10476192_ENST00000524462_KEAP1_chr19_10602938_ENST00000393623_length(amino acids)=599AA_BP=188
MCSPGRGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFR
RFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPV
EEEVNKEEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDS
RCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPD
GNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAV
GGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGR

--------------------------------------------------------------

>95651_95651_5_TYK2-KEAP1_TYK2_chr19_10476192_ENST00000525621_KEAP1_chr19_10602938_ENST00000171111_length(amino acids)=748AA_BP=337
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHI
LEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRF
GTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEVAKQEEFFNLSHCQLVTLISRDD
LNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGR
LIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRI
GVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTI
RSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTR

--------------------------------------------------------------

>95651_95651_6_TYK2-KEAP1_TYK2_chr19_10476192_ENST00000525621_KEAP1_chr19_10602938_ENST00000393623_length(amino acids)=748AA_BP=337
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHI
LEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRF
GTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEVAKQEEFFNLSHCQLVTLISRDD
LNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGR
LIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRI
GVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTI
RSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTR

--------------------------------------------------------------

>95651_95651_7_TYK2-KEAP1_TYK2_chr19_10476192_ENST00000529370_KEAP1_chr19_10602938_ENST00000171111_length(amino acids)=748AA_BP=337
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHI
LEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRF
GTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEVAKQEEFFNLSHCQLVTLISRDD
LNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGR
LIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRI
GVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTI
RSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTR

--------------------------------------------------------------

>95651_95651_8_TYK2-KEAP1_TYK2_chr19_10476192_ENST00000529370_KEAP1_chr19_10602938_ENST00000393623_length(amino acids)=748AA_BP=337
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHI
LEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRF
GTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEVAKQEEFFNLSHCQLVTLISRDD
LNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGR
LIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRI
GVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTI
RSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTR

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10490291/chr19:10610756)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	KEAP1 Q14145
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:14585973, PubMed:15379550, PubMed:15572695, PubMed:15983046, PubMed:15601839). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:15601839, PubMed:16006525). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:19489739, PubMed:16006525, PubMed:17127771, PubMed:18251510, PubMed:29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 (PubMed:20452972). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (PubMed:28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (PubMed:15379550, PubMed:17046835). {ECO:0000269\|PubMed:14585973, ECO:0000269\|PubMed:15379550, ECO:0000269\|PubMed:15572695, ECO:0000269\|PubMed:15601839, ECO:0000269\|PubMed:15983046, ECO:0000269\|PubMed:16006525, ECO:0000269\|PubMed:17046835, ECO:0000269\|PubMed:17127771, ECO:0000269\|PubMed:18251510, ECO:0000269\|PubMed:19489739, ECO:0000269\|PubMed:20452972, ECO:0000269\|PubMed:28380357, ECO:0000269\|PubMed:29590092}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KEAP1

chr19:10476192

chr19:10602938

ENST00000171111

327_372

213.0

625.0

Repeat

Note=Kelch 1

Tgene

KEAP1

chr19:10476192

chr19:10602938

ENST00000171111

373_423

213.0

625.0

Repeat

Note=Kelch 2

Tgene

KEAP1

chr19:10476192

chr19:10602938

ENST00000171111

424_470

213.0

625.0

Repeat

Note=Kelch 3

Tgene

KEAP1

chr19:10476192

chr19:10602938

ENST00000171111

471_517

213.0

625.0

Repeat

Note=Kelch 4

Tgene

KEAP1

chr19:10476192

chr19:10602938

ENST00000171111

518_564

213.0

625.0

Repeat

Note=Kelch 5

Tgene

KEAP1

chr19:10476192

chr19:10602938

ENST00000171111

565_611

213.0

625.0

Repeat

Note=Kelch 6

Tgene

KEAP1

chr19:10476192

chr19:10602938

ENST00000393623

327_372

213.0

625.0

Repeat

Note=Kelch 1

Tgene

KEAP1

chr19:10476192

chr19:10602938

ENST00000393623

373_423

213.0

625.0

Repeat

Note=Kelch 2

Tgene

KEAP1

chr19:10476192

chr19:10602938

ENST00000393623

424_470

213.0

625.0

Repeat

Note=Kelch 3

Tgene

KEAP1

chr19:10476192

chr19:10602938

ENST00000393623

471_517

213.0

625.0

Repeat

Note=Kelch 4

Tgene

KEAP1

chr19:10476192

chr19:10602938

ENST00000393623

518_564

213.0

625.0

Repeat

Note=Kelch 5

Tgene

KEAP1

chr19:10476192

chr19:10602938

ENST00000393623

565_611

213.0

625.0

Repeat

Note=Kelch 6

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TYK2

chr19:10476192

chr19:10602938

ENST00000264818

26_431

337.0

1188.0

Domain

FERM

Hgene

TYK2

chr19:10476192

chr19:10602938

ENST00000264818

450_529

337.0

1188.0

Domain

Note=SH2%3B atypical

Hgene

TYK2

chr19:10476192

chr19:10602938

ENST00000264818

589_875

337.0

1188.0

Domain

Protein kinase 1

Hgene

TYK2

chr19:10476192

chr19:10602938

ENST00000264818

897_1176

337.0

1188.0

Domain

Protein kinase 2

Hgene

TYK2

chr19:10476192

chr19:10602938

ENST00000525621

26_431

337.0

1188.0

Domain

FERM

Hgene

TYK2

chr19:10476192

chr19:10602938

ENST00000525621

450_529

337.0

1188.0

Domain

Note=SH2%3B atypical

Hgene

TYK2

chr19:10476192

chr19:10602938

ENST00000525621

589_875

337.0

1188.0

Domain

Protein kinase 1

Hgene

TYK2

chr19:10476192

chr19:10602938

ENST00000525621

897_1176

337.0

1188.0

Domain

Protein kinase 2

Hgene

TYK2

chr19:10476192

chr19:10602938

ENST00000264818

903_911

337.0

1188.0

Nucleotide binding

ATP

Hgene

TYK2

chr19:10476192

chr19:10602938

ENST00000525621

903_911

337.0

1188.0

Nucleotide binding

ATP

Tgene

KEAP1

chr19:10476192

chr19:10602938

ENST00000171111

184_286

213.0

625.0

Domain

Note=BACK

Tgene

KEAP1

chr19:10476192

chr19:10602938

ENST00000171111

77_149

213.0

625.0

Domain

BTB

Tgene

KEAP1

chr19:10476192

chr19:10602938

ENST00000393623

184_286

213.0

625.0

Domain

Note=BACK

Tgene

KEAP1

chr19:10476192

chr19:10602938

ENST00000393623

77_149

213.0

625.0

Domain

BTB

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
TYK2
KEAP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to TYK2-KEAP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to TYK2-KEAP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source