UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:UCK2-PBX1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: UCK2-PBX1
FusionPDB ID: 96569
FusionGDB2.0 ID: 96569
HgeneTgene
Gene symbol

UCK2

PBX1

Gene ID

7371

5087

Gene nameuridine-cytidine kinase 2PBX homeobox 1
SynonymsTSA903|UK|UMPKCAKUHED
Cytomap

1q24.1

1q23.3

Type of geneprotein-codingprotein-coding
Descriptionuridine-cytidine kinase 2cytidine monophosphokinase 2testis-specific protein TSA903uridine kinaseuridine monophosphate kinaseuridine monophosphokinase 2pre-B-cell leukemia transcription factor 1homeobox protein PBX1homeobox protein PRLpre-B-cell leukemia homeobox 1
Modification date2020031320200313
UniProtAcc.

P40424

Ensembl transtripts involved in fusion geneENST idsENST00000372212, ENST00000462329, 
ENST00000367879, ENST00000469256, 
ENST00000470820, 		ENST00000367897, 
ENST00000401534, ENST00000420696, 
ENST00000540236, ENST00000559240, 
ENST00000560641, ENST00000474046, 
ENST00000485769, ENST00000540246, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 9 X 9=137713 X 13 X 8=1352
# samples 2017
** MAII scorelog2(20/1377*10)=-2.78345665436024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1352*10)=-2.99148850014448
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: UCK2 [Title/Abstract] AND PBX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)UCK2(165797169)-PBX1(164761731), # samples:3
UCK2(165860559)-PBX1(164532475), # samples:3
Anticipated loss of major functional domain due to fusion event.UCK2-PBX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
UCK2-PBX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
UCK2-PBX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
UCK2-PBX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
UCK2-PBX1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
UCK2-PBX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
UCK2-PBX1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
UCK2-PBX1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across UCK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PBX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1315-01AUCK2chr1

165797169

-PBX1chr1

164761731

+
ChimerDB4OVTCGA-25-1315-01AUCK2chr1

165797169

+PBX1chr1

164761731

+
ChimerDB4SARCTCGA-X6-A8C6-01AUCK2chr1

165860559

-PBX1chr1

164532475

+
ChimerDB4SARCTCGA-X6-A8C6-01AUCK2chr1

165860559

+PBX1chr1

164532475

+
ChimerDB4STADTCGA-VQ-A92D-01AUCK2chr1

165875206

-PBX1chr1

164761731

+
ChimerDB4STADTCGA-VQ-A92D-01AUCK2chr1

165875206

+PBX1chr1

164761731

+
ChimerDB4STADTCGA-VQ-A92DUCK2chr1

165875206

+PBX1chr1

164761730

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367879UCK2chr1165860559+ENST00000420696PBX1chr1164532475+69166591201760546
ENST00000367879UCK2chr1165860559+ENST00000401534PBX1chr1164532475+15126591201511463
ENST00000367879UCK2chr1165860559+ENST00000559240PBX1chr1164532475+14886591201487455
ENST00000367879UCK2chr1165860559+ENST00000367897PBX1chr1164532475+19276591201511463
ENST00000367879UCK2chr1165860559+ENST00000540236PBX1chr1164532475+17316591201730536
ENST00000372212UCK2chr1165860559+ENST00000420696PBX1chr1164532475+6625368121469485
ENST00000372212UCK2chr1165860559+ENST00000401534PBX1chr1164532475+1221368121220402
ENST00000372212UCK2chr1165860559+ENST00000559240PBX1chr1164532475+1197368121196394
ENST00000372212UCK2chr1165860559+ENST00000367897PBX1chr1164532475+1636368121220402
ENST00000372212UCK2chr1165860559+ENST00000540236PBX1chr1164532475+1440368121439475
ENST00000367879UCK2chr1165875206+ENST00000420696PBX1chr1164761731+71329491201976618
ENST00000367879UCK2chr1165875206+ENST00000401534PBX1chr1164761731+17289491201727535
ENST00000367879UCK2chr1165875206+ENST00000559240PBX1chr1164761731+17049491201703527
ENST00000367879UCK2chr1165875206+ENST00000367897PBX1chr1164761731+21439491201727535
ENST00000367879UCK2chr1165875206+ENST00000540236PBX1chr1164761731+19479491201946608
ENST00000469256UCK2chr1165875206+ENST00000420696PBX1chr1164761731+6545362461389447
ENST00000469256UCK2chr1165875206+ENST00000401534PBX1chr1164761731+1141362461140365
ENST00000469256UCK2chr1165875206+ENST00000559240PBX1chr1164761731+1117362461116357
ENST00000469256UCK2chr1165875206+ENST00000367897PBX1chr1164761731+1556362461140364
ENST00000469256UCK2chr1165875206+ENST00000540236PBX1chr1164761731+1360362461359438
ENST00000470820UCK2chr1165875206+ENST00000420696PBX1chr1164761731+70788954861922478
ENST00000470820UCK2chr1165875206+ENST00000401534PBX1chr1164761731+16748954861673395
ENST00000470820UCK2chr1165875206+ENST00000559240PBX1chr1164761731+16508954861649387
ENST00000470820UCK2chr1165875206+ENST00000367897PBX1chr1164761731+20898954861673395
ENST00000470820UCK2chr1165875206+ENST00000540236PBX1chr1164761731+18938954861892468
ENST00000367879UCK2chr1165875206+ENST00000420696PBX1chr1164761730+71329491201976618
ENST00000367879UCK2chr1165875206+ENST00000401534PBX1chr1164761730+17289491201727535
ENST00000367879UCK2chr1165875206+ENST00000559240PBX1chr1164761730+17049491201703527
ENST00000367879UCK2chr1165875206+ENST00000367897PBX1chr1164761730+21439491201727535
ENST00000367879UCK2chr1165875206+ENST00000540236PBX1chr1164761730+19479491201946608
ENST00000469256UCK2chr1165875206+ENST00000420696PBX1chr1164761730+6545362461389447
ENST00000469256UCK2chr1165875206+ENST00000401534PBX1chr1164761730+1141362461140365
ENST00000469256UCK2chr1165875206+ENST00000559240PBX1chr1164761730+1117362461116357
ENST00000469256UCK2chr1165875206+ENST00000367897PBX1chr1164761730+1556362461140364
ENST00000469256UCK2chr1165875206+ENST00000540236PBX1chr1164761730+1360362461359438
ENST00000470820UCK2chr1165875206+ENST00000420696PBX1chr1164761730+70788954861922478
ENST00000470820UCK2chr1165875206+ENST00000401534PBX1chr1164761730+16748954861673395
ENST00000470820UCK2chr1165875206+ENST00000559240PBX1chr1164761730+16508954861649387
ENST00000470820UCK2chr1165875206+ENST00000367897PBX1chr1164761730+20898954861673395
ENST00000470820UCK2chr1165875206+ENST00000540236PBX1chr1164761730+18938954861892468

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367879ENST00000420696UCK2chr1165860559+PBX1chr1164532475+0.0004427070.9995573
ENST00000367879ENST00000401534UCK2chr1165860559+PBX1chr1164532475+0.0110948440.9889052
ENST00000367879ENST00000559240UCK2chr1165860559+PBX1chr1164532475+0.0117880140.9882119
ENST00000367879ENST00000367897UCK2chr1165860559+PBX1chr1164532475+0.0101912120.9898088
ENST00000367879ENST00000540236UCK2chr1165860559+PBX1chr1164532475+0.012540320.98745966
ENST00000372212ENST00000420696UCK2chr1165860559+PBX1chr1164532475+0.000360310.99963963
ENST00000372212ENST00000401534UCK2chr1165860559+PBX1chr1164532475+0.009308790.9906911
ENST00000372212ENST00000559240UCK2chr1165860559+PBX1chr1164532475+0.0114644740.9885356
ENST00000372212ENST00000367897UCK2chr1165860559+PBX1chr1164532475+0.0073133810.9926866
ENST00000372212ENST00000540236UCK2chr1165860559+PBX1chr1164532475+0.0088327780.99116725
ENST00000367879ENST00000420696UCK2chr1165875206+PBX1chr1164761731+0.0006480290.9993519
ENST00000367879ENST00000401534UCK2chr1165875206+PBX1chr1164761731+0.0090564240.9909436
ENST00000367879ENST00000559240UCK2chr1165875206+PBX1chr1164761731+0.0111115240.98888844
ENST00000367879ENST00000367897UCK2chr1165875206+PBX1chr1164761731+0.0086005680.9913994
ENST00000367879ENST00000540236UCK2chr1165875206+PBX1chr1164761731+0.0119064760.98809355
ENST00000469256ENST00000420696UCK2chr1165875206+PBX1chr1164761731+0.0002695720.9997304
ENST00000469256ENST00000401534UCK2chr1165875206+PBX1chr1164761731+0.0032465340.9967534
ENST00000469256ENST00000559240UCK2chr1165875206+PBX1chr1164761731+0.0063496770.9936504
ENST00000469256ENST00000367897UCK2chr1165875206+PBX1chr1164761731+0.0038150850.9961849
ENST00000469256ENST00000540236UCK2chr1165875206+PBX1chr1164761731+0.0036645470.9963354
ENST00000470820ENST00000420696UCK2chr1165875206+PBX1chr1164761731+0.0002652390.9997347
ENST00000470820ENST00000401534UCK2chr1165875206+PBX1chr1164761731+0.001457080.9985429
ENST00000470820ENST00000559240UCK2chr1165875206+PBX1chr1164761731+0.0027925770.99720746
ENST00000470820ENST00000367897UCK2chr1165875206+PBX1chr1164761731+0.0019349890.99806505
ENST00000470820ENST00000540236UCK2chr1165875206+PBX1chr1164761731+0.0019945490.99800545
ENST00000367879ENST00000420696UCK2chr1165875206+PBX1chr1164761730+0.0006480290.9993519
ENST00000367879ENST00000401534UCK2chr1165875206+PBX1chr1164761730+0.0090564240.9909436
ENST00000367879ENST00000559240UCK2chr1165875206+PBX1chr1164761730+0.0111115240.98888844
ENST00000367879ENST00000367897UCK2chr1165875206+PBX1chr1164761730+0.0086005680.9913994
ENST00000367879ENST00000540236UCK2chr1165875206+PBX1chr1164761730+0.0119064760.98809355
ENST00000469256ENST00000420696UCK2chr1165875206+PBX1chr1164761730+0.0002695720.9997304
ENST00000469256ENST00000401534UCK2chr1165875206+PBX1chr1164761730+0.0032465340.9967534
ENST00000469256ENST00000559240UCK2chr1165875206+PBX1chr1164761730+0.0063496770.9936504
ENST00000469256ENST00000367897UCK2chr1165875206+PBX1chr1164761730+0.0038150850.9961849
ENST00000469256ENST00000540236UCK2chr1165875206+PBX1chr1164761730+0.0036645470.9963354
ENST00000470820ENST00000420696UCK2chr1165875206+PBX1chr1164761730+0.0002652390.9997347
ENST00000470820ENST00000401534UCK2chr1165875206+PBX1chr1164761730+0.001457080.9985429
ENST00000470820ENST00000559240UCK2chr1165875206+PBX1chr1164761730+0.0027925770.99720746
ENST00000470820ENST00000367897UCK2chr1165875206+PBX1chr1164761730+0.0019349890.99806505
ENST00000470820ENST00000540236UCK2chr1165875206+PBX1chr1164761730+0.0019945490.99800545

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>96569_96569_1_UCK2-PBX1_UCK2_chr1_165860559_ENST00000367879_PBX1_chr1_164532475_ENST00000367897_length(amino acids)=463AA_BP=179
MAPSGNPAPSPGSERLAGERQRPQPRQRPAAAAESGGSPTRARAGSVRPFAQAAGGGAARTMAGDSEQTLQNHQQPNGGEPFLIGVSGGT
ASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSR
KHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKL
SQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQA
TEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGG

--------------------------------------------------------------

>96569_96569_2_UCK2-PBX1_UCK2_chr1_165860559_ENST00000367879_PBX1_chr1_164532475_ENST00000401534_length(amino acids)=463AA_BP=179
MAPSGNPAPSPGSERLAGERQRPQPRQRPAAAAESGGSPTRARAGSVRPFAQAAGGGAARTMAGDSEQTLQNHQQPNGGEPFLIGVSGGT
ASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSR
KHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKL
SQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQA
TEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGG

--------------------------------------------------------------

>96569_96569_3_UCK2-PBX1_UCK2_chr1_165860559_ENST00000367879_PBX1_chr1_164532475_ENST00000420696_length(amino acids)=546AA_BP=179
MAPSGNPAPSPGSERLAGERQRPQPRQRPAAAAESGGSPTRARAGSVRPFAQAAGGGAARTMAGDSEQTLQNHQQPNGGEPFLIGVSGGT
ASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSR
KHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKL
SQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQA
TEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGS
SSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEGPGSV

--------------------------------------------------------------

>96569_96569_4_UCK2-PBX1_UCK2_chr1_165860559_ENST00000367879_PBX1_chr1_164532475_ENST00000540236_length(amino acids)=536AA_BP=179
MAPSGNPAPSPGSERLAGERQRPQPRQRPAAAAESGGSPTRARAGSVRPFAQAAGGGAARTMAGDSEQTLQNHQQPNGGEPFLIGVSGGT
ASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSR
KHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKL
SQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQA
TEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGS

--------------------------------------------------------------

>96569_96569_5_UCK2-PBX1_UCK2_chr1_165860559_ENST00000367879_PBX1_chr1_164532475_ENST00000559240_length(amino acids)=455AA_BP=179
MAPSGNPAPSPGSERLAGERQRPQPRQRPAAAAESGGSPTRARAGSVRPFAQAAGGGAARTMAGDSEQTLQNHQQPNGGEPFLIGVSGGT
ASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSR
KHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKL
SQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQA
TEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEGPGSVH

--------------------------------------------------------------

>96569_96569_6_UCK2-PBX1_UCK2_chr1_165860559_ENST00000372212_PBX1_chr1_164532475_ENST00000367897_length(amino acids)=402AA_BP=118
MAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFD
NELILKTLKEITEGKTVQIPVYDFVSHSRKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGG
SAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQL
KQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIY

--------------------------------------------------------------

>96569_96569_7_UCK2-PBX1_UCK2_chr1_165860559_ENST00000372212_PBX1_chr1_164532475_ENST00000401534_length(amino acids)=402AA_BP=118
MAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFD
NELILKTLKEITEGKTVQIPVYDFVSHSRKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGG
SAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQL
KQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIY

--------------------------------------------------------------

>96569_96569_8_UCK2-PBX1_UCK2_chr1_165860559_ENST00000372212_PBX1_chr1_164532475_ENST00000420696_length(amino acids)=485AA_BP=118
MAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFD
NELILKTLKEITEGKTVQIPVYDFVSHSRKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGG
SAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQL
KQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIY
AAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYS

--------------------------------------------------------------

>96569_96569_9_UCK2-PBX1_UCK2_chr1_165860559_ENST00000372212_PBX1_chr1_164532475_ENST00000540236_length(amino acids)=475AA_BP=118
MAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFD
NELILKTLKEITEGKTVQIPVYDFVSHSRKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGG
SAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQL
KQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIY
AAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYS

--------------------------------------------------------------

>96569_96569_10_UCK2-PBX1_UCK2_chr1_165860559_ENST00000372212_PBX1_chr1_164532475_ENST00000559240_length(amino acids)=394AA_BP=118
MAGDSEQTLQNHQQPNGGEPFLIGVSGGTASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFD
NELILKTLKEITEGKTVQIPVYDFVSHSRKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGG
SAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQL
KQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVDTLRHVISQTGGYSDGLAASQMYSP

--------------------------------------------------------------

>96569_96569_11_UCK2-PBX1_UCK2_chr1_165875206_ENST00000367879_PBX1_chr1_164761730_ENST00000367897_length(amino acids)=535AA_BP=276
MAPSGNPAPSPGSERLAGERQRPQPRQRPAAAAESGGSPTRARAGSVRPFAQAAGGGAARTMAGDSEQTLQNHQQPNGGEPFLIGVSGGT
ASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSR
KEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIP
RGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQAC
NEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPS

--------------------------------------------------------------

>96569_96569_12_UCK2-PBX1_UCK2_chr1_165875206_ENST00000367879_PBX1_chr1_164761730_ENST00000401534_length(amino acids)=535AA_BP=276
MAPSGNPAPSPGSERLAGERQRPQPRQRPAAAAESGGSPTRARAGSVRPFAQAAGGGAARTMAGDSEQTLQNHQQPNGGEPFLIGVSGGT
ASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSR
KEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIP
RGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQAC
NEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPS

--------------------------------------------------------------

>96569_96569_13_UCK2-PBX1_UCK2_chr1_165875206_ENST00000367879_PBX1_chr1_164761730_ENST00000420696_length(amino acids)=618AA_BP=276
MAPSGNPAPSPGSERLAGERQRPQPRQRPAAAAESGGSPTRARAGSVRPFAQAAGGGAARTMAGDSEQTLQNHQQPNGGEPFLIGVSGGT
ASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSR
KEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIP
RGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQAC
NEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPS
EEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQS

--------------------------------------------------------------

>96569_96569_14_UCK2-PBX1_UCK2_chr1_165875206_ENST00000367879_PBX1_chr1_164761730_ENST00000540236_length(amino acids)=608AA_BP=276
MAPSGNPAPSPGSERLAGERQRPQPRQRPAAAAESGGSPTRARAGSVRPFAQAAGGGAARTMAGDSEQTLQNHQQPNGGEPFLIGVSGGT
ASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSR
KEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIP
RGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQAC
NEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPS
EEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQS

--------------------------------------------------------------

>96569_96569_15_UCK2-PBX1_UCK2_chr1_165875206_ENST00000367879_PBX1_chr1_164761730_ENST00000559240_length(amino acids)=527AA_BP=276
MAPSGNPAPSPGSERLAGERQRPQPRQRPAAAAESGGSPTRARAGSVRPFAQAAGGGAARTMAGDSEQTLQNHQQPNGGEPFLIGVSGGT
ASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSR
KEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIP
RGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQAC
NEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPS

--------------------------------------------------------------

>96569_96569_16_UCK2-PBX1_UCK2_chr1_165875206_ENST00000367879_PBX1_chr1_164761731_ENST00000367897_length(amino acids)=535AA_BP=276
MAPSGNPAPSPGSERLAGERQRPQPRQRPAAAAESGGSPTRARAGSVRPFAQAAGGGAARTMAGDSEQTLQNHQQPNGGEPFLIGVSGGT
ASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSR
KEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIP
RGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQAC
NEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPS

--------------------------------------------------------------

>96569_96569_17_UCK2-PBX1_UCK2_chr1_165875206_ENST00000367879_PBX1_chr1_164761731_ENST00000401534_length(amino acids)=535AA_BP=276
MAPSGNPAPSPGSERLAGERQRPQPRQRPAAAAESGGSPTRARAGSVRPFAQAAGGGAARTMAGDSEQTLQNHQQPNGGEPFLIGVSGGT
ASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSR
KEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIP
RGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQAC
NEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPS

--------------------------------------------------------------

>96569_96569_18_UCK2-PBX1_UCK2_chr1_165875206_ENST00000367879_PBX1_chr1_164761731_ENST00000420696_length(amino acids)=618AA_BP=276
MAPSGNPAPSPGSERLAGERQRPQPRQRPAAAAESGGSPTRARAGSVRPFAQAAGGGAARTMAGDSEQTLQNHQQPNGGEPFLIGVSGGT
ASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSR
KEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIP
RGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQAC
NEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPS
EEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQS

--------------------------------------------------------------

>96569_96569_19_UCK2-PBX1_UCK2_chr1_165875206_ENST00000367879_PBX1_chr1_164761731_ENST00000540236_length(amino acids)=608AA_BP=276
MAPSGNPAPSPGSERLAGERQRPQPRQRPAAAAESGGSPTRARAGSVRPFAQAAGGGAARTMAGDSEQTLQNHQQPNGGEPFLIGVSGGT
ASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSR
KEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIP
RGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQAC
NEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPS
EEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQS

--------------------------------------------------------------

>96569_96569_20_UCK2-PBX1_UCK2_chr1_165875206_ENST00000367879_PBX1_chr1_164761731_ENST00000559240_length(amino acids)=527AA_BP=276
MAPSGNPAPSPGSERLAGERQRPQPRQRPAAAAESGGSPTRARAGSVRPFAQAAGGGAARTMAGDSEQTLQNHQQPNGGEPFLIGVSGGT
ASGKSSVCAKIVQLLGQNEVDYRQKQVVILSQDSFYRVLTSEQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSR
KEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIP
RGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQAC
NEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPS

--------------------------------------------------------------

>96569_96569_21_UCK2-PBX1_UCK2_chr1_165875206_ENST00000469256_PBX1_chr1_164761730_ENST00000367897_length(amino acids)=364AA_BP=105
MYFLTNAFSKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPT
KKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHT
ELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFY
SHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGGYPSPCYQPD

--------------------------------------------------------------

>96569_96569_22_UCK2-PBX1_UCK2_chr1_165875206_ENST00000469256_PBX1_chr1_164761730_ENST00000401534_length(amino acids)=365AA_BP=105
MYFLTNAFSKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPT
KKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHT
ELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFY
SHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGGYPSPCYQPD

--------------------------------------------------------------

>96569_96569_23_UCK2-PBX1_UCK2_chr1_165875206_ENST00000469256_PBX1_chr1_164761730_ENST00000420696_length(amino acids)=447AA_BP=105
MYFLTNAFSKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPT
KKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHT
ELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFY
SHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNS

--------------------------------------------------------------

>96569_96569_24_UCK2-PBX1_UCK2_chr1_165875206_ENST00000469256_PBX1_chr1_164761730_ENST00000540236_length(amino acids)=438AA_BP=105
MYFLTNAFSKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPT
KKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHT
ELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFY
SHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNS

--------------------------------------------------------------

>96569_96569_25_UCK2-PBX1_UCK2_chr1_165875206_ENST00000469256_PBX1_chr1_164761730_ENST00000559240_length(amino acids)=357AA_BP=105
MYFLTNAFSKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPT
KKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHT
ELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFY

--------------------------------------------------------------

>96569_96569_26_UCK2-PBX1_UCK2_chr1_165875206_ENST00000469256_PBX1_chr1_164761731_ENST00000367897_length(amino acids)=364AA_BP=105
MYFLTNAFSKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPT
KKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHT
ELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFY
SHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGGYPSPCYQPD

--------------------------------------------------------------

>96569_96569_27_UCK2-PBX1_UCK2_chr1_165875206_ENST00000469256_PBX1_chr1_164761731_ENST00000401534_length(amino acids)=365AA_BP=105
MYFLTNAFSKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPT
KKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHT
ELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFY
SHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGGYPSPCYQPD

--------------------------------------------------------------

>96569_96569_28_UCK2-PBX1_UCK2_chr1_165875206_ENST00000469256_PBX1_chr1_164761731_ENST00000420696_length(amino acids)=447AA_BP=105
MYFLTNAFSKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPT
KKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHT
ELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFY
SHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNS

--------------------------------------------------------------

>96569_96569_29_UCK2-PBX1_UCK2_chr1_165875206_ENST00000469256_PBX1_chr1_164761731_ENST00000540236_length(amino acids)=438AA_BP=105
MYFLTNAFSKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPT
KKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHT
ELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFY
SHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNS

--------------------------------------------------------------

>96569_96569_30_UCK2-PBX1_UCK2_chr1_165875206_ENST00000469256_PBX1_chr1_164761731_ENST00000559240_length(amino acids)=357AA_BP=105
MYFLTNAFSKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRDISERGRDLEQILSQYITFVKPAFEEFCLPT
KKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHT
ELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFY

--------------------------------------------------------------

>96569_96569_31_UCK2-PBX1_UCK2_chr1_165875206_ENST00000470820_PBX1_chr1_164761730_ENST00000367897_length(amino acids)=395AA_BP=136
MKSVGARNPEPSPARCSGPCSLSLASPCLAWPIICSVLCRKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLR
DISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAA
AAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEA
VMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVT

--------------------------------------------------------------

>96569_96569_32_UCK2-PBX1_UCK2_chr1_165875206_ENST00000470820_PBX1_chr1_164761730_ENST00000401534_length(amino acids)=395AA_BP=136
MKSVGARNPEPSPARCSGPCSLSLASPCLAWPIICSVLCRKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLR
DISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAA
AAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEA
VMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVT

--------------------------------------------------------------

>96569_96569_33_UCK2-PBX1_UCK2_chr1_165875206_ENST00000470820_PBX1_chr1_164761730_ENST00000420696_length(amino acids)=478AA_BP=136
MKSVGARNPEPSPARCSGPCSLSLASPCLAWPIICSVLCRKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLR
DISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAA
AAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEA
VMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVT
ATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISAN

--------------------------------------------------------------

>96569_96569_34_UCK2-PBX1_UCK2_chr1_165875206_ENST00000470820_PBX1_chr1_164761730_ENST00000540236_length(amino acids)=468AA_BP=136
MKSVGARNPEPSPARCSGPCSLSLASPCLAWPIICSVLCRKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLR
DISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAA
AAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEA
VMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVT
ATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISHL

--------------------------------------------------------------

>96569_96569_35_UCK2-PBX1_UCK2_chr1_165875206_ENST00000470820_PBX1_chr1_164761730_ENST00000559240_length(amino acids)=387AA_BP=136
MKSVGARNPEPSPARCSGPCSLSLASPCLAWPIICSVLCRKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLR
DISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAA
AAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEA
VMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANG

--------------------------------------------------------------

>96569_96569_36_UCK2-PBX1_UCK2_chr1_165875206_ENST00000470820_PBX1_chr1_164761731_ENST00000367897_length(amino acids)=395AA_BP=136
MKSVGARNPEPSPARCSGPCSLSLASPCLAWPIICSVLCRKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLR
DISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAA
AAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEA
VMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVT

--------------------------------------------------------------

>96569_96569_37_UCK2-PBX1_UCK2_chr1_165875206_ENST00000470820_PBX1_chr1_164761731_ENST00000401534_length(amino acids)=395AA_BP=136
MKSVGARNPEPSPARCSGPCSLSLASPCLAWPIICSVLCRKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLR
DISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAA
AAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEA
VMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVT

--------------------------------------------------------------

>96569_96569_38_UCK2-PBX1_UCK2_chr1_165875206_ENST00000470820_PBX1_chr1_164761731_ENST00000420696_length(amino acids)=478AA_BP=136
MKSVGARNPEPSPARCSGPCSLSLASPCLAWPIICSVLCRKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLR
DISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAA
AAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEA
VMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVT
ATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISAN

--------------------------------------------------------------

>96569_96569_39_UCK2-PBX1_UCK2_chr1_165875206_ENST00000470820_PBX1_chr1_164761731_ENST00000540236_length(amino acids)=468AA_BP=136
MKSVGARNPEPSPARCSGPCSLSLASPCLAWPIICSVLCRKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLR
DISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAA
AAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEA
VMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVT
ATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISHL

--------------------------------------------------------------

>96569_96569_40_UCK2-PBX1_UCK2_chr1_165875206_ENST00000470820_PBX1_chr1_164761731_ENST00000559240_length(amino acids)=387AA_BP=136
MKSVGARNPEPSPARCSGPCSLSLASPCLAWPIICSVLCRKEETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLR
DISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAA
AAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEA
VMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANG

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:165797169/chr1:164761731)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.PBX1

P40424

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 (PubMed:9191052). Binds to the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein (PubMed:9191052). Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 (PubMed:8327485, PubMed:7791786). Acts as a transcriptional activator of PF4 in complex with MEIS1 (PubMed:12609849). Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence (By similarity). In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development (By similarity). Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1) (By similarity). Probably in complex with MEIS2, involved in transcriptional regulation by KLF4 (PubMed:21746878). Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B (By similarity). Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression (By similarity). {ECO:0000250|UniProtKB:P41778, ECO:0000269|PubMed:12609849, ECO:0000269|PubMed:21746878, ECO:0000269|PubMed:7791786, ECO:0000269|PubMed:8327485, ECO:0000269|PubMed:9191052}.; FUNCTION: [Isoform PBX1b]: As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. {ECO:0000250|UniProtKB:P41778}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUCK2chr1:165860559chr1:164532475ENST00000367879+3727_35118.66666666666667262.0Nucleotide bindingNote=ATP
HgeneUCK2chr1:165875206chr1:164761730ENST00000367879+6727_35215.33333333333334262.0Nucleotide bindingNote=ATP
HgeneUCK2chr1:165875206chr1:164761731ENST00000367879+6727_35215.33333333333334262.0Nucleotide bindingNote=ATP
TgenePBX1chr1:165860559chr1:164532475ENST0000036789708127_13563.666666666666664408.3333333333333Compositional biasNote=Poly-Ala
TgenePBX1chr1:165860559chr1:164532475ENST0000040153407127_13563.666666666666664348.0Compositional biasNote=Poly-Ala
TgenePBX1chr1:165860559chr1:164532475ENST0000042069609127_13563.666666666666664431.0Compositional biasNote=Poly-Ala
TgenePBX1chr1:165860559chr1:164532475ENST0000054023609127_13563.666666666666664421.0Compositional biasNote=Poly-Ala
TgenePBX1chr1:165875206chr1:164761730ENST0000036789718127_13588.33333333333333408.3333333333333Compositional biasNote=Poly-Ala
TgenePBX1chr1:165875206chr1:164761730ENST0000040153417127_13588.33333333333333348.0Compositional biasNote=Poly-Ala
TgenePBX1chr1:165875206chr1:164761730ENST0000042069619127_13588.33333333333333431.0Compositional biasNote=Poly-Ala
TgenePBX1chr1:165875206chr1:164761730ENST0000054023619127_13588.33333333333333421.0Compositional biasNote=Poly-Ala
TgenePBX1chr1:165875206chr1:164761731ENST0000036789718127_13588.33333333333333408.3333333333333Compositional biasNote=Poly-Ala
TgenePBX1chr1:165875206chr1:164761731ENST0000040153417127_13588.33333333333333348.0Compositional biasNote=Poly-Ala
TgenePBX1chr1:165875206chr1:164761731ENST0000042069619127_13588.33333333333333431.0Compositional biasNote=Poly-Ala
TgenePBX1chr1:165875206chr1:164761731ENST0000054023619127_13588.33333333333333421.0Compositional biasNote=Poly-Ala
TgenePBX1chr1:165860559chr1:164532475ENST0000036789708233_29563.666666666666664408.3333333333333DNA bindingHomeobox%3B TALE-type
TgenePBX1chr1:165860559chr1:164532475ENST0000040153407233_29563.666666666666664348.0DNA bindingHomeobox%3B TALE-type
TgenePBX1chr1:165860559chr1:164532475ENST0000042069609233_29563.666666666666664431.0DNA bindingHomeobox%3B TALE-type
TgenePBX1chr1:165860559chr1:164532475ENST0000054023609233_29563.666666666666664421.0DNA bindingHomeobox%3B TALE-type
TgenePBX1chr1:165875206chr1:164761730ENST0000036789718233_29588.33333333333333408.3333333333333DNA bindingHomeobox%3B TALE-type
TgenePBX1chr1:165875206chr1:164761730ENST0000040153417233_29588.33333333333333348.0DNA bindingHomeobox%3B TALE-type
TgenePBX1chr1:165875206chr1:164761730ENST0000042069619233_29588.33333333333333431.0DNA bindingHomeobox%3B TALE-type
TgenePBX1chr1:165875206chr1:164761730ENST0000054023619233_29588.33333333333333421.0DNA bindingHomeobox%3B TALE-type
TgenePBX1chr1:165875206chr1:164761731ENST0000036789718233_29588.33333333333333408.3333333333333DNA bindingHomeobox%3B TALE-type
TgenePBX1chr1:165875206chr1:164761731ENST0000040153417233_29588.33333333333333348.0DNA bindingHomeobox%3B TALE-type
TgenePBX1chr1:165875206chr1:164761731ENST0000042069619233_29588.33333333333333431.0DNA bindingHomeobox%3B TALE-type
TgenePBX1chr1:165875206chr1:164761731ENST0000054023619233_29588.33333333333333421.0DNA bindingHomeobox%3B TALE-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePBX1chr1:165860559chr1:164532475ENST000003678970840_23263.666666666666664408.3333333333333DomainPBC
TgenePBX1chr1:165860559chr1:164532475ENST000004015340740_23263.666666666666664348.0DomainPBC
TgenePBX1chr1:165860559chr1:164532475ENST000004206960940_23263.666666666666664431.0DomainPBC
TgenePBX1chr1:165860559chr1:164532475ENST000005402360940_23263.666666666666664421.0DomainPBC
TgenePBX1chr1:165875206chr1:164761730ENST000003678971840_23288.33333333333333408.3333333333333DomainPBC
TgenePBX1chr1:165875206chr1:164761730ENST000004015341740_23288.33333333333333348.0DomainPBC
TgenePBX1chr1:165875206chr1:164761730ENST000004206961940_23288.33333333333333431.0DomainPBC
TgenePBX1chr1:165875206chr1:164761730ENST000005402361940_23288.33333333333333421.0DomainPBC
TgenePBX1chr1:165875206chr1:164761731ENST000003678971840_23288.33333333333333408.3333333333333DomainPBC
TgenePBX1chr1:165875206chr1:164761731ENST000004015341740_23288.33333333333333348.0DomainPBC
TgenePBX1chr1:165875206chr1:164761731ENST000004206961940_23288.33333333333333431.0DomainPBC
TgenePBX1chr1:165875206chr1:164761731ENST000005402361940_23288.33333333333333421.0DomainPBC


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
UCK2
PBX1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to UCK2-PBX1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to UCK2-PBX1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePBX1C0006413Burkitt Lymphoma2CTD_human;ORPHANET
TgenePBX1C0343640African Burkitt's lymphoma2CTD_human
TgenePBX1C1968949Cakut2GENOMICS_ENGLAND
TgenePBX1C4721444Burkitt Leukemia2CTD_human
TgenePBX1C0013146Drug abuse1CTD_human
TgenePBX1C0013170Drug habituation1CTD_human
TgenePBX1C0013222Drug Use Disorders1CTD_human
TgenePBX1C0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgenePBX1C0038580Substance Dependence1CTD_human
TgenePBX1C0038586Substance Use Disorders1CTD_human
TgenePBX1C0236969Substance-Related Disorders1CTD_human
TgenePBX1C0431692Bilateral renal hypoplasia1ORPHANET
TgenePBX1C0740858Substance abuse problem1CTD_human
TgenePBX1C1510472Drug Dependence1CTD_human
TgenePBX1C4316881Prescription Drug Abuse1CTD_human
TgenePBX1C4539968CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT SYNDROME WITH OR WITHOUT HEARING LOSS, ABNORMAL EARS, OR DEVELOPMENTAL DELAY1GENOMICS_ENGLAND