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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:BICD1-ZNF438

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: BICD1-ZNF438
FusionPDB ID: 9704
FusionGDB2.0 ID: 9704
HgeneTgene
Gene symbol

BICD1

ZNF438

Gene ID

636

220929

Gene nameBICD cargo adaptor 1zinc finger protein 438
SynonymsBICD|bic-D 1bA330O11.1
Cytomap

12p11.21

10p11.23

Type of geneprotein-codingprotein-coding
Descriptionprotein bicaudal D homolog 1bicaudal D homolog 1cytoskeleton-like bicaudal D protein homolog 1zinc finger protein 438
Modification date2020031320200313
UniProtAcc

Q96G01

.
Ensembl transtripts involved in fusion geneENST idsENST00000281474, ENST00000548411, 
ENST00000550207, ENST00000551086, 
ENST00000551848, 		ENST00000375311, 
ENST00000444692, ENST00000331737, 
ENST00000361310, ENST00000413025, 
ENST00000436087, ENST00000442986, 
ENST00000452305, ENST00000538351, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score22 X 18 X 10=39606 X 8 X 7=336
# samples 259
** MAII scorelog2(25/3960*10)=-3.98550043030488
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: BICD1 [Title/Abstract] AND ZNF438 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)BICD1(32491913)-ZNF438(31138372), # samples:3
Anticipated loss of major functional domain due to fusion event.BICD1-ZNF438 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BICD1-ZNF438 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBICD1

GO:0033365

protein localization to organelle

12447383|20089649


check buttonFusion gene breakpoints across BICD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF438 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DB-5277-01ABICD1chr12

32491913

-ZNF438chr10

31138372

-
ChimerDB4LGGTCGA-DB-5277-01ABICD1chr12

32491913

+ZNF438chr10

31138372

-
ChimerDB4LGGTCGA-DB-5277BICD1chr12

32491913

+ZNF438chr10

31138372

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000281474BICD1chr1232491913+ENST00000331737ZNF438chr1031138372-47202867822904940
ENST00000281474BICD1chr1232491913+ENST00000361310ZNF438chr1031138372-47202867822904940
ENST00000281474BICD1chr1232491913+ENST00000413025ZNF438chr1031138372-47162867822904940
ENST00000281474BICD1chr1232491913+ENST00000436087ZNF438chr1031138372-47162867822904940
ENST00000281474BICD1chr1232491913+ENST00000452305ZNF438chr1031138372-47162867822904940
ENST00000281474BICD1chr1232491913+ENST00000442986ZNF438chr1031138372-47162867822904940
ENST00000281474BICD1chr1232491913+ENST00000538351ZNF438chr1031138372-45822867822904940

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000281474ENST00000331737BICD1chr1232491913+ZNF438chr1031138372-0.0032348430.99676514
ENST00000281474ENST00000361310BICD1chr1232491913+ZNF438chr1031138372-0.0032348430.99676514
ENST00000281474ENST00000413025BICD1chr1232491913+ZNF438chr1031138372-0.0032105530.9967894
ENST00000281474ENST00000436087BICD1chr1232491913+ZNF438chr1031138372-0.0032105530.9967894
ENST00000281474ENST00000452305BICD1chr1232491913+ZNF438chr1031138372-0.0032105530.9967894
ENST00000281474ENST00000442986BICD1chr1232491913+ZNF438chr1031138372-0.0032105530.9967894
ENST00000281474ENST00000538351BICD1chr1232491913+ZNF438chr1031138372-0.0037547220.9962452

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>9704_9704_1_BICD1-ZNF438_BICD1_chr12_32491913_ENST00000281474_ZNF438_chr10_31138372_ENST00000331737_length(amino acids)=940AA_BP=
MPPSTGAMAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKV
AEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYT
ELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHI
SISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQ
LEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNK
SVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRV
MLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPM
NIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKY
ENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQ
SRRSKGKLGKSKIGSPKVSGEASVTVPTIDTYLLHSQGPQTPNIRVSSGTQRKRQFSPSLCDQSRPRTSGASYLQNLLRVPPDPTSTESF

--------------------------------------------------------------

>9704_9704_2_BICD1-ZNF438_BICD1_chr12_32491913_ENST00000281474_ZNF438_chr10_31138372_ENST00000361310_length(amino acids)=940AA_BP=
MPPSTGAMAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKV
AEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYT
ELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHI
SISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQ
LEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNK
SVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRV
MLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPM
NIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKY
ENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQ
SRRSKGKLGKSKIGSPKVSGEASVTVPTIDTYLLHSQGPQTPNIRVSSGTQRKRQFSPSLCDQSRPRTSGASYLQNLLRVPPDPTSTESF

--------------------------------------------------------------

>9704_9704_3_BICD1-ZNF438_BICD1_chr12_32491913_ENST00000281474_ZNF438_chr10_31138372_ENST00000413025_length(amino acids)=940AA_BP=
MPPSTGAMAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKV
AEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYT
ELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHI
SISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQ
LEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNK
SVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRV
MLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPM
NIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKY
ENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQ
SRRSKGKLGKSKIGSPKVSGEASVTVPTIDTYLLHSQGPQTPNIRVSSGTQRKRQFSPSLCDQSRPRTSGASYLQNLLRVPPDPTSTESF

--------------------------------------------------------------

>9704_9704_4_BICD1-ZNF438_BICD1_chr12_32491913_ENST00000281474_ZNF438_chr10_31138372_ENST00000436087_length(amino acids)=940AA_BP=
MPPSTGAMAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKV
AEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYT
ELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHI
SISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQ
LEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNK
SVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRV
MLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPM
NIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKY
ENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQ
SRRSKGKLGKSKIGSPKVSGEASVTVPTIDTYLLHSQGPQTPNIRVSSGTQRKRQFSPSLCDQSRPRTSGASYLQNLLRVPPDPTSTESF

--------------------------------------------------------------

>9704_9704_5_BICD1-ZNF438_BICD1_chr12_32491913_ENST00000281474_ZNF438_chr10_31138372_ENST00000442986_length(amino acids)=940AA_BP=
MPPSTGAMAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKV
AEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYT
ELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHI
SISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQ
LEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNK
SVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRV
MLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPM
NIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKY
ENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQ
SRRSKGKLGKSKIGSPKVSGEASVTVPTIDTYLLHSQGPQTPNIRVSSGTQRKRQFSPSLCDQSRPRTSGASYLQNLLRVPPDPTSTESF

--------------------------------------------------------------

>9704_9704_6_BICD1-ZNF438_BICD1_chr12_32491913_ENST00000281474_ZNF438_chr10_31138372_ENST00000452305_length(amino acids)=940AA_BP=
MPPSTGAMAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKV
AEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYT
ELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHI
SISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQ
LEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNK
SVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRV
MLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPM
NIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKY
ENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQ
SRRSKGKLGKSKIGSPKVSGEASVTVPTIDTYLLHSQGPQTPNIRVSSGTQRKRQFSPSLCDQSRPRTSGASYLQNLLRVPPDPTSTESF

--------------------------------------------------------------

>9704_9704_7_BICD1-ZNF438_BICD1_chr12_32491913_ENST00000281474_ZNF438_chr10_31138372_ENST00000538351_length(amino acids)=940AA_BP=
MPPSTGAMAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKV
AEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYT
ELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHI
SISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQ
LEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNK
SVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRV
MLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPM
NIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKY
ENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQ
SRRSKGKLGKSKIGSPKVSGEASVTVPTIDTYLLHSQGPQTPNIRVSSGTQRKRQFSPSLCDQSRPRTSGASYLQNLLRVPPDPTSTESF

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:32491913/chr10:31138372)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BICD1

Q96G01

.
FUNCTION: Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBICD1chr12:32491913chr10:31138372ENST00000281474+8101_265921.3333333333334976.0Coiled coilOntology_term=ECO:0000255
HgeneBICD1chr12:32491913chr10:31138372ENST00000281474+810319_496921.3333333333334976.0Coiled coilOntology_term=ECO:0000255
HgeneBICD1chr12:32491913chr10:31138372ENST00000281474+810663_803921.3333333333334976.0Coiled coilOntology_term=ECO:0000255
TgeneZNF438chr12:32491913chr10:31138372ENST0000033173708507_5290819.0Zinc fingerC2H2-type 1
TgeneZNF438chr12:32491913chr10:31138372ENST0000033173708535_5570819.0Zinc fingerC2H2-type 2
TgeneZNF438chr12:32491913chr10:31138372ENST0000033173708567_5900819.0Zinc fingerC2H2-type 3
TgeneZNF438chr12:32491913chr10:31138372ENST0000033173708776_7990819.0Zinc fingerC2H2-type 4
TgeneZNF438chr12:32491913chr10:31138372ENST0000036131007507_5290829.0Zinc fingerC2H2-type 1
TgeneZNF438chr12:32491913chr10:31138372ENST0000036131007535_5570829.0Zinc fingerC2H2-type 2
TgeneZNF438chr12:32491913chr10:31138372ENST0000036131007567_5900829.0Zinc fingerC2H2-type 3
TgeneZNF438chr12:32491913chr10:31138372ENST0000036131007776_7990829.0Zinc fingerC2H2-type 4
TgeneZNF438chr12:32491913chr10:31138372ENST0000041302506507_5290829.0Zinc fingerC2H2-type 1
TgeneZNF438chr12:32491913chr10:31138372ENST0000041302506535_5570829.0Zinc fingerC2H2-type 2
TgeneZNF438chr12:32491913chr10:31138372ENST0000041302506567_5900829.0Zinc fingerC2H2-type 3
TgeneZNF438chr12:32491913chr10:31138372ENST0000041302506776_7990829.0Zinc fingerC2H2-type 4
TgeneZNF438chr12:32491913chr10:31138372ENST0000043608708507_5290829.0Zinc fingerC2H2-type 1
TgeneZNF438chr12:32491913chr10:31138372ENST0000043608708535_5570829.0Zinc fingerC2H2-type 2
TgeneZNF438chr12:32491913chr10:31138372ENST0000043608708567_5900829.0Zinc fingerC2H2-type 3
TgeneZNF438chr12:32491913chr10:31138372ENST0000043608708776_7990829.0Zinc fingerC2H2-type 4
TgeneZNF438chr12:32491913chr10:31138372ENST0000044298608507_5290829.0Zinc fingerC2H2-type 1
TgeneZNF438chr12:32491913chr10:31138372ENST0000044298608535_5570829.0Zinc fingerC2H2-type 2
TgeneZNF438chr12:32491913chr10:31138372ENST0000044298608567_5900829.0Zinc fingerC2H2-type 3
TgeneZNF438chr12:32491913chr10:31138372ENST0000044298608776_7990829.0Zinc fingerC2H2-type 4
TgeneZNF438chr12:32491913chr10:31138372ENST0000044469203507_5290.0819.0Zinc fingerC2H2-type 1
TgeneZNF438chr12:32491913chr10:31138372ENST0000044469203535_5570.0819.0Zinc fingerC2H2-type 2
TgeneZNF438chr12:32491913chr10:31138372ENST0000044469203567_5900.0819.0Zinc fingerC2H2-type 3
TgeneZNF438chr12:32491913chr10:31138372ENST0000044469203776_7990.0819.0Zinc fingerC2H2-type 4
TgeneZNF438chr12:32491913chr10:31138372ENST0000045230509507_5290819.0Zinc fingerC2H2-type 1
TgeneZNF438chr12:32491913chr10:31138372ENST0000045230509535_5570819.0Zinc fingerC2H2-type 2
TgeneZNF438chr12:32491913chr10:31138372ENST0000045230509567_5900819.0Zinc fingerC2H2-type 3
TgeneZNF438chr12:32491913chr10:31138372ENST0000045230509776_7990819.0Zinc fingerC2H2-type 4
TgeneZNF438chr12:32491913chr10:31138372ENST0000053835108507_5290780.0Zinc fingerC2H2-type 1
TgeneZNF438chr12:32491913chr10:31138372ENST0000053835108535_5570780.0Zinc fingerC2H2-type 2
TgeneZNF438chr12:32491913chr10:31138372ENST0000053835108567_5900780.0Zinc fingerC2H2-type 3
TgeneZNF438chr12:32491913chr10:31138372ENST0000053835108776_7990780.0Zinc fingerC2H2-type 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBICD1chr12:32491913chr10:31138372ENST00000548411+191_26502736.0Coiled coilOntology_term=ECO:0000255
HgeneBICD1chr12:32491913chr10:31138372ENST00000548411+19319_49602736.0Coiled coilOntology_term=ECO:0000255
HgeneBICD1chr12:32491913chr10:31138372ENST00000548411+19663_80302736.0Coiled coilOntology_term=ECO:0000255
HgeneBICD1chr12:32491913chr10:31138372ENST00000551848+111_265094.0Coiled coilOntology_term=ECO:0000255
HgeneBICD1chr12:32491913chr10:31138372ENST00000551848+11319_496094.0Coiled coilOntology_term=ECO:0000255
HgeneBICD1chr12:32491913chr10:31138372ENST00000551848+11663_803094.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1733_BICD1_32491913_ZNF438_31138372_ranked_0.pdbBICD13249191332491913ENST00000538351ZNF438chr1031138372-
MPPSTGAMAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKV
AEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYT
ELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHI
SISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQ
LEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNK
SVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRV
MLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPM
NIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKY
ENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQ
SRRSKGKLGKSKIGSPKVSGEASVTVPTIDTYLLHSQGPQTPNIRVSSGTQRKRQFSPSLCDQSRPRTSGASYLQNLLRVPPDPTSTESF
940


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
BICD1_pLDDT.png
all structure
all structure
ZNF438_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
BICD1
ZNF438


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to BICD1-ZNF438


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to BICD1-ZNF438


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource