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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:URI1-KCNIP4

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: URI1-KCNIP4
	FusionPDB ID: 97075
	FusionGDB2.0 ID: 97075
		Hgene	Tgene
	Gene symbol	URI1	KCNIP4
	Gene ID	8725	80333
	Gene name	URI1 prefoldin like chaperone	potassium voltage-gated channel interacting protein 4
	Synonyms	C19orf2\|NNX3\|PPP1R19\|RMP\|URI	CALP\|KCHIP4
	Cytomap	19q12	4p15.31-p15.2
	Type of gene	protein-coding	protein-coding
	Description	unconventional prefoldin RPB5 interactor 1RNA polymerase II subunit 5-mediating proteinRPB5-mediating proteinprotein phosphatase 1, regulatory subunit 19	Kv channel-interacting protein 4Kv channel interacting protein 4a-type potassium channel modulatory protein 4calsenilin-like protein
	Modification date	20200313	20200313
	UniProtAcc	O94763	Q6PIL6
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000312051, ENST00000360605, ENST00000392271, ENST00000542441, ENST00000574176,	ENST00000359001, ENST00000382149, ENST00000509207, ENST00000382148, ENST00000382150, ENST00000382152, ENST00000447367,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	30 X 13 X 12=4680	18 X 13 X 9=2106
	# samples	40	19
	** MAII score	log2(40/4680*10)=-3.54843662469604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/2106*10)=-3.47043411269477 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: URI1 [Title/Abstract] AND KCNIP4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	URI1(30477324)-KCNIP4(20852290), # samples:2
Anticipated loss of major functional domain due to fusion event.	URI1-KCNIP4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. URI1-KCNIP4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. URI1-KCNIP4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. URI1-KCNIP4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	URI1	GO:0000122	negative regulation of transcription by RNA polymerase II	12737519\|15367675\|21730289
Hgene	URI1	GO:0001558	regulation of cell growth	21730289
Hgene	URI1	GO:0071363	cellular response to growth factor stimulus	17936702
Hgene	URI1	GO:0071383	cellular response to steroid hormone stimulus	21730289

Fusion gene breakpoints across URI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KCNIP4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	TGCT	TCGA-YU-A90P-01A	URI1	chr19	30477324	+	KCNIP4	chr4	20852290	-
ChimerDB4	TGCT	TCGA-YU-A90P	URI1	chr19	30477324	+	KCNIP4	chr4	20852290	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000360605	URI1	chr19	30477324	+	ENST00000382148	KCNIP4	chr4	20852290	-	2417	361	30	950	306
ENST00000360605	URI1	chr19	30477324	+	ENST00000447367	KCNIP4	chr4	20852290	-	1827	361	30	950	306
ENST00000360605	URI1	chr19	30477324	+	ENST00000382150	KCNIP4	chr4	20852290	-	1823	361	30	950	306
ENST00000360605	URI1	chr19	30477324	+	ENST00000382152	KCNIP4	chr4	20852290	-	1797	361	30	950	306
ENST00000542441	URI1	chr19	30477324	+	ENST00000382148	KCNIP4	chr4	20852290	-	2720	664	297	1253	318
ENST00000542441	URI1	chr19	30477324	+	ENST00000447367	KCNIP4	chr4	20852290	-	2130	664	297	1253	318
ENST00000542441	URI1	chr19	30477324	+	ENST00000382150	KCNIP4	chr4	20852290	-	2126	664	297	1253	318
ENST00000542441	URI1	chr19	30477324	+	ENST00000382152	KCNIP4	chr4	20852290	-	2100	664	297	1253	318
ENST00000392271	URI1	chr19	30477324	+	ENST00000382148	KCNIP4	chr4	20852290	-	2720	664	297	1253	318
ENST00000392271	URI1	chr19	30477324	+	ENST00000447367	KCNIP4	chr4	20852290	-	2130	664	297	1253	318
ENST00000392271	URI1	chr19	30477324	+	ENST00000382150	KCNIP4	chr4	20852290	-	2126	664	297	1253	318
ENST00000392271	URI1	chr19	30477324	+	ENST00000382152	KCNIP4	chr4	20852290	-	2100	664	297	1253	318
ENST00000312051	URI1	chr19	30477324	+	ENST00000382148	KCNIP4	chr4	20852290	-	2418	362	10	951	313
ENST00000312051	URI1	chr19	30477324	+	ENST00000447367	KCNIP4	chr4	20852290	-	1828	362	10	951	313
ENST00000312051	URI1	chr19	30477324	+	ENST00000382150	KCNIP4	chr4	20852290	-	1824	362	10	951	313
ENST00000312051	URI1	chr19	30477324	+	ENST00000382152	KCNIP4	chr4	20852290	-	1798	362	10	951	313

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000360605	ENST00000382148	URI1	chr19	30477324	+	KCNIP4	chr4	20852290	-	0.000199947	0.9998
ENST00000360605	ENST00000447367	URI1	chr19	30477324	+	KCNIP4	chr4	20852290	-	0.000189483	0.9998105
ENST00000360605	ENST00000382150	URI1	chr19	30477324	+	KCNIP4	chr4	20852290	-	0.000186628	0.9998134
ENST00000360605	ENST00000382152	URI1	chr19	30477324	+	KCNIP4	chr4	20852290	-	0.000192777	0.9998073
ENST00000542441	ENST00000382148	URI1	chr19	30477324	+	KCNIP4	chr4	20852290	-	0.000416	0.999584
ENST00000542441	ENST00000447367	URI1	chr19	30477324	+	KCNIP4	chr4	20852290	-	0.000427203	0.9995728
ENST00000542441	ENST00000382150	URI1	chr19	30477324	+	KCNIP4	chr4	20852290	-	0.000419024	0.9995809
ENST00000542441	ENST00000382152	URI1	chr19	30477324	+	KCNIP4	chr4	20852290	-	0.00043674	0.9995633
ENST00000392271	ENST00000382148	URI1	chr19	30477324	+	KCNIP4	chr4	20852290	-	0.000416	0.999584
ENST00000392271	ENST00000447367	URI1	chr19	30477324	+	KCNIP4	chr4	20852290	-	0.000427203	0.9995728
ENST00000392271	ENST00000382150	URI1	chr19	30477324	+	KCNIP4	chr4	20852290	-	0.000419024	0.9995809
ENST00000392271	ENST00000382152	URI1	chr19	30477324	+	KCNIP4	chr4	20852290	-	0.00043674	0.9995633
ENST00000312051	ENST00000382148	URI1	chr19	30477324	+	KCNIP4	chr4	20852290	-	0.000612798	0.99938715
ENST00000312051	ENST00000447367	URI1	chr19	30477324	+	KCNIP4	chr4	20852290	-	0.000543209	0.9994568
ENST00000312051	ENST00000382150	URI1	chr19	30477324	+	KCNIP4	chr4	20852290	-	0.000537451	0.99946254
ENST00000312051	ENST00000382152	URI1	chr19	30477324	+	KCNIP4	chr4	20852290	-	0.000569619	0.99943036

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>97075_97075_1_URI1-KCNIP4_URI1_chr19_30477324_ENST00000312051_KCNIP4_chr4_20852290_ENST00000382148_length(amino acids)=313AA_BP=118
MRPAGPSWRRPPWRRPPTPRPLRPRPLPWFRCAPRMWRGCARSRKRKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNE
VTVLLGDNWFAKCSAKQAVGLVEHRKEHSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFP
QGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQ

--------------------------------------------------------------

>97075_97075_2_URI1-KCNIP4_URI1_chr19_30477324_ENST00000312051_KCNIP4_chr4_20852290_ENST00000382150_length(amino acids)=313AA_BP=118
MRPAGPSWRRPPWRRPPTPRPLRPRPLPWFRCAPRMWRGCARSRKRKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNE
VTVLLGDNWFAKCSAKQAVGLVEHRKEHSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFP
QGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQ

--------------------------------------------------------------

>97075_97075_3_URI1-KCNIP4_URI1_chr19_30477324_ENST00000312051_KCNIP4_chr4_20852290_ENST00000382152_length(amino acids)=313AA_BP=118
MRPAGPSWRRPPWRRPPTPRPLRPRPLPWFRCAPRMWRGCARSRKRKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNE
VTVLLGDNWFAKCSAKQAVGLVEHRKEHSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFP
QGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQ

--------------------------------------------------------------

>97075_97075_4_URI1-KCNIP4_URI1_chr19_30477324_ENST00000312051_KCNIP4_chr4_20852290_ENST00000447367_length(amino acids)=313AA_BP=118
MRPAGPSWRRPPWRRPPTPRPLRPRPLPWFRCAPRMWRGCARSRKRKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNE
VTVLLGDNWFAKCSAKQAVGLVEHRKEHSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFP
QGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQ

--------------------------------------------------------------

>97075_97075_5_URI1-KCNIP4_URI1_chr19_30477324_ENST00000360605_KCNIP4_chr4_20852290_ENST00000382148_length(amino acids)=306AA_BP=111
MEVTALMTTWSSLQGSHVSKRALAYALVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNEVTVLLGD
NWFAKCSAKQAVGLVEHRKEHSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTY
AHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQ

--------------------------------------------------------------

>97075_97075_6_URI1-KCNIP4_URI1_chr19_30477324_ENST00000360605_KCNIP4_chr4_20852290_ENST00000382150_length(amino acids)=306AA_BP=111
MEVTALMTTWSSLQGSHVSKRALAYALVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNEVTVLLGD
NWFAKCSAKQAVGLVEHRKEHSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTY
AHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQ

--------------------------------------------------------------

>97075_97075_7_URI1-KCNIP4_URI1_chr19_30477324_ENST00000360605_KCNIP4_chr4_20852290_ENST00000382152_length(amino acids)=306AA_BP=111
MEVTALMTTWSSLQGSHVSKRALAYALVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNEVTVLLGD
NWFAKCSAKQAVGLVEHRKEHSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTY
AHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQ

--------------------------------------------------------------

>97075_97075_8_URI1-KCNIP4_URI1_chr19_30477324_ENST00000360605_KCNIP4_chr4_20852290_ENST00000447367_length(amino acids)=306AA_BP=111
MEVTALMTTWSSLQGSHVSKRALAYALVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNEVTVLLGD
NWFAKCSAKQAVGLVEHRKEHSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTY
AHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQ

--------------------------------------------------------------

>97075_97075_9_URI1-KCNIP4_URI1_chr19_30477324_ENST00000392271_KCNIP4_chr4_20852290_ENST00000382148_length(amino acids)=318AA_BP=123
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKL
VHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIY
SQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKE

--------------------------------------------------------------

>97075_97075_10_URI1-KCNIP4_URI1_chr19_30477324_ENST00000392271_KCNIP4_chr4_20852290_ENST00000382150_length(amino acids)=318AA_BP=123
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKL
VHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIY
SQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKE

--------------------------------------------------------------

>97075_97075_11_URI1-KCNIP4_URI1_chr19_30477324_ENST00000392271_KCNIP4_chr4_20852290_ENST00000382152_length(amino acids)=318AA_BP=123
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKL
VHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIY
SQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKE

--------------------------------------------------------------

>97075_97075_12_URI1-KCNIP4_URI1_chr19_30477324_ENST00000392271_KCNIP4_chr4_20852290_ENST00000447367_length(amino acids)=318AA_BP=123
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKL
VHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIY
SQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKE

--------------------------------------------------------------

>97075_97075_13_URI1-KCNIP4_URI1_chr19_30477324_ENST00000542441_KCNIP4_chr4_20852290_ENST00000382148_length(amino acids)=318AA_BP=123
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKL
VHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIY
SQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKE

--------------------------------------------------------------

>97075_97075_14_URI1-KCNIP4_URI1_chr19_30477324_ENST00000542441_KCNIP4_chr4_20852290_ENST00000382150_length(amino acids)=318AA_BP=123
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKL
VHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIY
SQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKE

--------------------------------------------------------------

>97075_97075_15_URI1-KCNIP4_URI1_chr19_30477324_ENST00000542441_KCNIP4_chr4_20852290_ENST00000382152_length(amino acids)=318AA_BP=123
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKL
VHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIY
SQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKE

--------------------------------------------------------------

>97075_97075_16_URI1-KCNIP4_URI1_chr19_30477324_ENST00000542441_KCNIP4_chr4_20852290_ENST00000447367_length(amino acids)=318AA_BP=123
MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKL
VHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIY
SQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:30477324/chr4:20852290)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
URI1 O94763	KCNIP4 Q6PIL6
FUNCTION: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.	FUNCTION: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435). Modulates KCND3/Kv4.3 currents (PubMed:23576435). Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed:18957440). Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane. {ECO:0000250\|UniProtKB:Q6PHZ8, ECO:0000269\|PubMed:11847232, ECO:0000269\|PubMed:18957440, ECO:0000269\|PubMed:23576435}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000359001

133_144

189.0

Calcium binding

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000359001

169_180

189.0

Calcium binding

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000359001

217_228

189.0

Calcium binding

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382148

133_144

29.333333333333332

226.0

Calcium binding

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382148

169_180

29.333333333333332

226.0

Calcium binding

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382148

217_228

29.333333333333332

226.0

Calcium binding

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382150

133_144

33.333333333333336

230.0

Calcium binding

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382150

169_180

33.333333333333336

230.0

Calcium binding

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382150

217_228

33.333333333333336

230.0

Calcium binding

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382152

133_144

54.333333333333336

251.0

Calcium binding

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382152

169_180

54.333333333333336

251.0

Calcium binding

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382152

217_228

54.333333333333336

251.0

Calcium binding

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000447367

133_144

20.333333333333332

217.0

Calcium binding

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000447367

169_180

20.333333333333332

217.0

Calcium binding

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000447367

217_228

20.333333333333332

217.0

Calcium binding

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000509207

133_144

189.0

Calcium binding

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000509207

169_180

189.0

Calcium binding

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000509207

217_228

189.0

Calcium binding

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000359001

120_155

189.0

Domain

EF-hand 2

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000359001

156_191

189.0

Domain

EF-hand 3

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000359001

204_239

189.0

Domain

EF-hand 4

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000359001

61_117

189.0

Domain

EF-hand 1%3B degenerate

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382148

120_155

29.333333333333332

226.0

Domain

EF-hand 2

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382148

156_191

29.333333333333332

226.0

Domain

EF-hand 3

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382148

204_239

29.333333333333332

226.0

Domain

EF-hand 4

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382148

61_117

29.333333333333332

226.0

Domain

EF-hand 1%3B degenerate

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382150

120_155

33.333333333333336

230.0

Domain

EF-hand 2

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382150

156_191

33.333333333333336

230.0

Domain

EF-hand 3

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382150

204_239

33.333333333333336

230.0

Domain

EF-hand 4

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382150

61_117

33.333333333333336

230.0

Domain

EF-hand 1%3B degenerate

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382152

120_155

54.333333333333336

251.0

Domain

EF-hand 2

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382152

156_191

54.333333333333336

251.0

Domain

EF-hand 3

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382152

204_239

54.333333333333336

251.0

Domain

EF-hand 4

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382152

61_117

54.333333333333336

251.0

Domain

EF-hand 1%3B degenerate

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000447367

120_155

20.333333333333332

217.0

Domain

EF-hand 2

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000447367

156_191

20.333333333333332

217.0

Domain

EF-hand 3

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000447367

204_239

20.333333333333332

217.0

Domain

EF-hand 4

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000447367

61_117

20.333333333333332

217.0

Domain

EF-hand 1%3B degenerate

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000509207

120_155

189.0

Domain

EF-hand 2

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000509207

156_191

189.0

Domain

EF-hand 3

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000509207

204_239

189.0

Domain

EF-hand 4

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000509207

61_117

189.0

Domain

EF-hand 1%3B degenerate

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000359001

2_44

189.0

Region

KIS

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000509207

2_44

189.0

Region

KIS

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

URI1

chr19:30477324

chr4:20852290

ENST00000360605

299_311

104.33333333333333

476.0

Compositional bias

Note=Poly-Asp

Hgene

URI1

chr19:30477324

chr4:20852290

ENST00000360605

314_321

104.33333333333333

476.0

Compositional bias

Note=Poly-Asp

Hgene

URI1

chr19:30477324

chr4:20852290

ENST00000392271

299_311

46.333333333333336

460.0

Compositional bias

Note=Poly-Asp

Hgene

URI1

chr19:30477324

chr4:20852290

ENST00000392271

314_321

46.333333333333336

460.0

Compositional bias

Note=Poly-Asp

Hgene

URI1

chr19:30477324

chr4:20852290

ENST00000542441

299_311

122.33333333333333

536.0

Compositional bias

Note=Poly-Asp

Hgene

URI1

chr19:30477324

chr4:20852290

ENST00000542441

314_321

122.33333333333333

536.0

Compositional bias

Note=Poly-Asp

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382148

2_44

29.333333333333332

226.0

Region

KIS

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382150

2_44

33.333333333333336

230.0

Region

KIS

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000382152

2_44

54.333333333333336

251.0

Region

KIS

Tgene

KCNIP4

chr19:30477324

chr4:20852290

ENST00000447367

2_44

20.333333333333332

217.0

Region

KIS

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>584_URI1_30477324_KCNIP4_20852290_ranked_0.pdb	URI1	30477324	30477324	ENST00000382152	KCNIP4	chr4	20852290	-	MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKL VHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIY SQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKE	318

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

URI1_pLDDT.png

KCNIP4_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
URI1
KCNIP4

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to URI1-KCNIP4

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to URI1-KCNIP4

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source