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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:UST-MYB

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: UST-MYB
	FusionPDB ID: 97695
	FusionGDB2.0 ID: 97695
		Hgene	Tgene
	Gene symbol	UST	MYB
	Gene ID	10090	4602
	Gene name	uronyl 2-sulfotransferase	MYB proto-oncogene, transcription factor
	Synonyms	2OST	Cmyb\|c-myb\|c-myb_CDS\|efg
	Cytomap	6q25.1	6q23.3
	Type of gene	protein-coding	protein-coding
	Description	uronyl 2-sulfotransferasedermatan/chondroitin sulfate 2-sulfotransferase	transcriptional activator Myboncogene AMVproto-oncogene c-Mybv-myb avian myeloblastosis viral oncogene homolog
	Modification date	20200313	20200313
	UniProtAcc	.	A2RUH7
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000367463, ENST00000466695,	ENST00000531845, ENST00000420123, ENST00000527615, ENST00000341911, ENST00000367814, ENST00000525369, ENST00000316528, ENST00000442647, ENST00000528774, ENST00000533624, ENST00000534044, ENST00000534121,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 8 X 5=400	7 X 7 X 4=196
	# samples	12	8
	** MAII score	log2(12/400*10)=-1.73696559416621 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/196*10)=-1.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: UST [Title/Abstract] AND MYB [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	UST(149208165)-MYB(135539002), # samples:2
Anticipated loss of major functional domain due to fusion event.	UST-MYB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. UST-MYB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. UST-MYB seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. UST-MYB seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. UST-MYB seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. UST-MYB seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MYB	GO:0045944	positive regulation of transcription by RNA polymerase II	10233885\|20484083

Fusion gene breakpoints across UST (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-04-1356-01A	UST	chr6	149208165	+	MYB	chr6	135539002	+
ChimerDB4	OV	TCGA-04-1356	UST	chr6	149208165	+	MYB	chr6	135539001	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000367463	UST	chr6	149208165	+	ENST00000316528	MYB	chr6	135539002	+	1702	394	462	1	154
ENST00000367463	UST	chr6	149208165	+	ENST00000442647	MYB	chr6	135539002	+	1702	394	462	1	154
ENST00000367463	UST	chr6	149208165	+	ENST00000534121	MYB	chr6	135539002	+	511	394	462	1	154
ENST00000367463	UST	chr6	149208165	+	ENST00000533624	MYB	chr6	135539002	+	511	394	462	1	154
ENST00000367463	UST	chr6	149208165	+	ENST00000534044	MYB	chr6	135539002	+	511	394	462	1	154
ENST00000367463	UST	chr6	149208165	+	ENST00000528774	MYB	chr6	135539002	+	511	394	462	1	154
ENST00000367463	UST	chr6	149208165	+	ENST00000316528	MYB	chr6	135539001	+	1702	394	462	1	154
ENST00000367463	UST	chr6	149208165	+	ENST00000442647	MYB	chr6	135539001	+	1702	394	462	1	154
ENST00000367463	UST	chr6	149208165	+	ENST00000534121	MYB	chr6	135539001	+	511	394	462	1	154
ENST00000367463	UST	chr6	149208165	+	ENST00000533624	MYB	chr6	135539001	+	511	394	462	1	154
ENST00000367463	UST	chr6	149208165	+	ENST00000534044	MYB	chr6	135539001	+	511	394	462	1	154
ENST00000367463	UST	chr6	149208165	+	ENST00000528774	MYB	chr6	135539001	+	511	394	462	1	154

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000367463	ENST00000316528	UST	chr6	149208165	+	MYB	chr6	135539002	+	0.16430028	0.8356997
ENST00000367463	ENST00000442647	UST	chr6	149208165	+	MYB	chr6	135539002	+	0.16430028	0.8356997
ENST00000367463	ENST00000534121	UST	chr6	149208165	+	MYB	chr6	135539002	+	0.024409428	0.9755906
ENST00000367463	ENST00000533624	UST	chr6	149208165	+	MYB	chr6	135539002	+	0.024409428	0.9755906
ENST00000367463	ENST00000534044	UST	chr6	149208165	+	MYB	chr6	135539002	+	0.024409428	0.9755906
ENST00000367463	ENST00000528774	UST	chr6	149208165	+	MYB	chr6	135539002	+	0.024409428	0.9755906
ENST00000367463	ENST00000316528	UST	chr6	149208165	+	MYB	chr6	135539001	+	0.16430028	0.8356997
ENST00000367463	ENST00000442647	UST	chr6	149208165	+	MYB	chr6	135539001	+	0.16430028	0.8356997
ENST00000367463	ENST00000534121	UST	chr6	149208165	+	MYB	chr6	135539001	+	0.024409428	0.9755906
ENST00000367463	ENST00000533624	UST	chr6	149208165	+	MYB	chr6	135539001	+	0.024409428	0.9755906
ENST00000367463	ENST00000534044	UST	chr6	149208165	+	MYB	chr6	135539001	+	0.024409428	0.9755906
ENST00000367463	ENST00000528774	UST	chr6	149208165	+	MYB	chr6	135539001	+	0.024409428	0.9755906

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>97695_97695_1_UST-MYB_UST_chr6_149208165_ENST00000367463_MYB_chr6_135539001_ENST00000316528_length(amino acids)=154AA_BP=1
MTGRCHLLLHLSTGCRFPGTATRLTRRWSMVIQVSGISQVLPQVEQEARGSPAELIEEGAQAEDQQGGHAEAVVPEGEAQERQQGHPTLP

--------------------------------------------------------------

>97695_97695_2_UST-MYB_UST_chr6_149208165_ENST00000367463_MYB_chr6_135539001_ENST00000442647_length(amino acids)=154AA_BP=1
MTGRCHLLLHLSTGCRFPGTATRLTRRWSMVIQVSGISQVLPQVEQEARGSPAELIEEGAQAEDQQGGHAEAVVPEGEAQERQQGHPTLP

--------------------------------------------------------------

>97695_97695_3_UST-MYB_UST_chr6_149208165_ENST00000367463_MYB_chr6_135539001_ENST00000528774_length(amino acids)=154AA_BP=1
MTGRCHLLLHLSTGCRFPGTATRLTRRWSMVIQVSGISQVLPQVEQEARGSPAELIEEGAQAEDQQGGHAEAVVPEGEAQERQQGHPTLP

--------------------------------------------------------------

>97695_97695_4_UST-MYB_UST_chr6_149208165_ENST00000367463_MYB_chr6_135539001_ENST00000533624_length(amino acids)=154AA_BP=1
MTGRCHLLLHLSTGCRFPGTATRLTRRWSMVIQVSGISQVLPQVEQEARGSPAELIEEGAQAEDQQGGHAEAVVPEGEAQERQQGHPTLP

--------------------------------------------------------------

>97695_97695_5_UST-MYB_UST_chr6_149208165_ENST00000367463_MYB_chr6_135539001_ENST00000534044_length(amino acids)=154AA_BP=1
MTGRCHLLLHLSTGCRFPGTATRLTRRWSMVIQVSGISQVLPQVEQEARGSPAELIEEGAQAEDQQGGHAEAVVPEGEAQERQQGHPTLP

--------------------------------------------------------------

>97695_97695_6_UST-MYB_UST_chr6_149208165_ENST00000367463_MYB_chr6_135539001_ENST00000534121_length(amino acids)=154AA_BP=1
MTGRCHLLLHLSTGCRFPGTATRLTRRWSMVIQVSGISQVLPQVEQEARGSPAELIEEGAQAEDQQGGHAEAVVPEGEAQERQQGHPTLP

--------------------------------------------------------------

>97695_97695_7_UST-MYB_UST_chr6_149208165_ENST00000367463_MYB_chr6_135539002_ENST00000316528_length(amino acids)=154AA_BP=1
MTGRCHLLLHLSTGCRFPGTATRLTRRWSMVIQVSGISQVLPQVEQEARGSPAELIEEGAQAEDQQGGHAEAVVPEGEAQERQQGHPTLP

--------------------------------------------------------------

>97695_97695_8_UST-MYB_UST_chr6_149208165_ENST00000367463_MYB_chr6_135539002_ENST00000442647_length(amino acids)=154AA_BP=1
MTGRCHLLLHLSTGCRFPGTATRLTRRWSMVIQVSGISQVLPQVEQEARGSPAELIEEGAQAEDQQGGHAEAVVPEGEAQERQQGHPTLP

--------------------------------------------------------------

>97695_97695_9_UST-MYB_UST_chr6_149208165_ENST00000367463_MYB_chr6_135539002_ENST00000528774_length(amino acids)=154AA_BP=1
MTGRCHLLLHLSTGCRFPGTATRLTRRWSMVIQVSGISQVLPQVEQEARGSPAELIEEGAQAEDQQGGHAEAVVPEGEAQERQQGHPTLP

--------------------------------------------------------------

>97695_97695_10_UST-MYB_UST_chr6_149208165_ENST00000367463_MYB_chr6_135539002_ENST00000533624_length(amino acids)=154AA_BP=1
MTGRCHLLLHLSTGCRFPGTATRLTRRWSMVIQVSGISQVLPQVEQEARGSPAELIEEGAQAEDQQGGHAEAVVPEGEAQERQQGHPTLP

--------------------------------------------------------------

>97695_97695_11_UST-MYB_UST_chr6_149208165_ENST00000367463_MYB_chr6_135539002_ENST00000534044_length(amino acids)=154AA_BP=1
MTGRCHLLLHLSTGCRFPGTATRLTRRWSMVIQVSGISQVLPQVEQEARGSPAELIEEGAQAEDQQGGHAEAVVPEGEAQERQQGHPTLP

--------------------------------------------------------------

>97695_97695_12_UST-MYB_UST_chr6_149208165_ENST00000367463_MYB_chr6_135539002_ENST00000534121_length(amino acids)=154AA_BP=1
MTGRCHLLLHLSTGCRFPGTATRLTRRWSMVIQVSGISQVLPQVEQEARGSPAELIEEGAQAEDQQGGHAEAVVPEGEAQERQQGHPTLP

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:149208165/chr6:135539002)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MYB A2RUH7
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Myosin-binding protein which plays a role in cardiac function (PubMed:28778945). Seems to regulate conduction in the atria and ventricular conduction systems (PubMed:28778945). {ECO:0000269\|PubMed:28778945}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UST

chr6:149208165

chr6:135539001

ENST00000367463

1_49

97.0

407.0

Topological domain

Cytoplasmic

Hgene

UST

chr6:149208165

chr6:135539002

ENST00000367463

1_49

97.0

407.0

Topological domain

Cytoplasmic

Hgene

UST

chr6:149208165

chr6:135539001

ENST00000367463

50_70

97.0

407.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

UST

chr6:149208165

chr6:135539002

ENST00000367463

50_70

97.0

407.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

UST

chr6:149208165

chr6:135539001

ENST00000367463

71_406

97.0

407.0

Topological domain

Lumenal

Hgene

UST

chr6:149208165

chr6:135539002

ENST00000367463

71_406

97.0

407.0

Topological domain

Lumenal

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000341911

115_138

723.0

762.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000341911

166_189

723.0

762.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000341911

63_86

723.0

762.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000367814

115_138

602.0

641.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000367814

166_189

602.0

641.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000367814

63_86

602.0

641.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000442647

115_138

599.0

638.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000442647

166_189

599.0

638.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000442647

63_86

599.0

638.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000525369

115_138

517.0

556.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000525369

166_189

517.0

556.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000525369

63_86

517.0

556.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000528774

115_138

720.0

759.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000528774

166_189

720.0

759.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000528774

63_86

720.0

759.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000533624

115_138

567.0

606.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000533624

166_189

567.0

606.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000533624

63_86

567.0

606.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000534044

115_138

565.0

604.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000534044

166_189

565.0

604.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000534044

63_86

565.0

604.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000534121

115_138

707.0

746.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000534121

166_189

707.0

746.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000534121

63_86

707.0

746.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000341911

115_138

723.0

762.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000341911

166_189

723.0

762.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000341911

63_86

723.0

762.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000367814

115_138

602.0

641.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000367814

166_189

602.0

641.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000367814

63_86

602.0

641.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000442647

115_138

599.0

638.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000442647

166_189

599.0

638.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000442647

63_86

599.0

638.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000525369

115_138

517.0

556.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000525369

166_189

517.0

556.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000525369

63_86

517.0

556.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000528774

115_138

720.0

759.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000528774

166_189

720.0

759.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000528774

63_86

720.0

759.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000533624

115_138

567.0

606.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000533624

166_189

567.0

606.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000533624

63_86

567.0

606.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000534044

115_138

565.0

604.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000534044

166_189

565.0

604.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000534044

63_86

565.0

604.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000534121

115_138

707.0

746.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000534121

166_189

707.0

746.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000534121

63_86

707.0

746.0

DNA binding

H-T-H motif

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000341911

143_193

723.0

762.0

Domain

HTH myb-type 3

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000341911

35_86

723.0

762.0

Domain

HTH myb-type 1

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000341911

87_142

723.0

762.0

Domain

HTH myb-type 2

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000367814

143_193

602.0

641.0

Domain

HTH myb-type 3

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000367814

35_86

602.0

641.0

Domain

HTH myb-type 1

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000367814

87_142

602.0

641.0

Domain

HTH myb-type 2

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000442647

143_193

599.0

638.0

Domain

HTH myb-type 3

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000442647

35_86

599.0

638.0

Domain

HTH myb-type 1

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000442647

87_142

599.0

638.0

Domain

HTH myb-type 2

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000525369

143_193

517.0

556.0

Domain

HTH myb-type 3

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000525369

35_86

517.0

556.0

Domain

HTH myb-type 1

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000525369

87_142

517.0

556.0

Domain

HTH myb-type 2

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000528774

143_193

720.0

759.0

Domain

HTH myb-type 3

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000528774

35_86

720.0

759.0

Domain

HTH myb-type 1

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000528774

87_142

720.0

759.0

Domain

HTH myb-type 2

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000533624

143_193

567.0

606.0

Domain

HTH myb-type 3

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000533624

35_86

567.0

606.0

Domain

HTH myb-type 1

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000533624

87_142

567.0

606.0

Domain

HTH myb-type 2

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000534044

143_193

565.0

604.0

Domain

HTH myb-type 3

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000534044

35_86

565.0

604.0

Domain

HTH myb-type 1

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000534044

87_142

565.0

604.0

Domain

HTH myb-type 2

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000534121

143_193

707.0

746.0

Domain

HTH myb-type 3

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000534121

35_86

707.0

746.0

Domain

HTH myb-type 1

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000534121

87_142

707.0

746.0

Domain

HTH myb-type 2

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000341911

143_193

723.0

762.0

Domain

HTH myb-type 3

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000341911

35_86

723.0

762.0

Domain

HTH myb-type 1

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000341911

87_142

723.0

762.0

Domain

HTH myb-type 2

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000367814

143_193

602.0

641.0

Domain

HTH myb-type 3

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000367814

35_86

602.0

641.0

Domain

HTH myb-type 1

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000367814

87_142

602.0

641.0

Domain

HTH myb-type 2

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000442647

143_193

599.0

638.0

Domain

HTH myb-type 3

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000442647

35_86

599.0

638.0

Domain

HTH myb-type 1

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000442647

87_142

599.0

638.0

Domain

HTH myb-type 2

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000525369

143_193

517.0

556.0

Domain

HTH myb-type 3

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000525369

35_86

517.0

556.0

Domain

HTH myb-type 1

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000525369

87_142

517.0

556.0

Domain

HTH myb-type 2

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000528774

143_193

720.0

759.0

Domain

HTH myb-type 3

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000528774

35_86

720.0

759.0

Domain

HTH myb-type 1

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000528774

87_142

720.0

759.0

Domain

HTH myb-type 2

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000533624

143_193

567.0

606.0

Domain

HTH myb-type 3

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000533624

35_86

567.0

606.0

Domain

HTH myb-type 1

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000533624

87_142

567.0

606.0

Domain

HTH myb-type 2

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000534044

143_193

565.0

604.0

Domain

HTH myb-type 3

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000534044

35_86

565.0

604.0

Domain

HTH myb-type 1

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000534044

87_142

565.0

604.0

Domain

HTH myb-type 2

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000534121

143_193

707.0

746.0

Domain

HTH myb-type 3

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000534121

35_86

707.0

746.0

Domain

HTH myb-type 1

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000534121

87_142

707.0

746.0

Domain

HTH myb-type 2

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000341911

275_327

723.0

762.0

Region

Transcription activation domain (PubMed:2189102)

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000341911

328_465

723.0

762.0

Region

Negative regulatory domain

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000341911

376_397

723.0

762.0

Region

Note=Leucine-zipper

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000367814

275_327

602.0

641.0

Region

Transcription activation domain (PubMed:2189102)

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000367814

328_465

602.0

641.0

Region

Negative regulatory domain

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000367814

376_397

602.0

641.0

Region

Note=Leucine-zipper

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000442647

275_327

599.0

638.0

Region

Transcription activation domain (PubMed:2189102)

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000442647

328_465

599.0

638.0

Region

Negative regulatory domain

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000442647

376_397

599.0

638.0

Region

Note=Leucine-zipper

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000525369

275_327

517.0

556.0

Region

Transcription activation domain (PubMed:2189102)

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000525369

328_465

517.0

556.0

Region

Negative regulatory domain

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000525369

376_397

517.0

556.0

Region

Note=Leucine-zipper

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000528774

275_327

720.0

759.0

Region

Transcription activation domain (PubMed:2189102)

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000528774

328_465

720.0

759.0

Region

Negative regulatory domain

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000528774

376_397

720.0

759.0

Region

Note=Leucine-zipper

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000533624

275_327

567.0

606.0

Region

Transcription activation domain (PubMed:2189102)

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000533624

328_465

567.0

606.0

Region

Negative regulatory domain

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000533624

376_397

567.0

606.0

Region

Note=Leucine-zipper

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000534044

275_327

565.0

604.0

Region

Transcription activation domain (PubMed:2189102)

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000534044

328_465

565.0

604.0

Region

Negative regulatory domain

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000534044

376_397

565.0

604.0

Region

Note=Leucine-zipper

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000534121

275_327

707.0

746.0

Region

Transcription activation domain (PubMed:2189102)

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000534121

328_465

707.0

746.0

Region

Negative regulatory domain

Tgene

MYB

chr6:149208165

chr6:135539001

ENST00000534121

376_397

707.0

746.0

Region

Note=Leucine-zipper

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000341911

275_327

723.0

762.0

Region

Transcription activation domain (PubMed:2189102)

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000341911

328_465

723.0

762.0

Region

Negative regulatory domain

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000341911

376_397

723.0

762.0

Region

Note=Leucine-zipper

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000367814

275_327

602.0

641.0

Region

Transcription activation domain (PubMed:2189102)

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000367814

328_465

602.0

641.0

Region

Negative regulatory domain

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000367814

376_397

602.0

641.0

Region

Note=Leucine-zipper

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000442647

275_327

599.0

638.0

Region

Transcription activation domain (PubMed:2189102)

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000442647

328_465

599.0

638.0

Region

Negative regulatory domain

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000442647

376_397

599.0

638.0

Region

Note=Leucine-zipper

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000525369

275_327

517.0

556.0

Region

Transcription activation domain (PubMed:2189102)

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000525369

328_465

517.0

556.0

Region

Negative regulatory domain

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000525369

376_397

517.0

556.0

Region

Note=Leucine-zipper

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000528774

275_327

720.0

759.0

Region

Transcription activation domain (PubMed:2189102)

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000528774

328_465

720.0

759.0

Region

Negative regulatory domain

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000528774

376_397

720.0

759.0

Region

Note=Leucine-zipper

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000533624

275_327

567.0

606.0

Region

Transcription activation domain (PubMed:2189102)

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000533624

328_465

567.0

606.0

Region

Negative regulatory domain

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000533624

376_397

567.0

606.0

Region

Note=Leucine-zipper

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000534044

275_327

565.0

604.0

Region

Transcription activation domain (PubMed:2189102)

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000534044

328_465

565.0

604.0

Region

Negative regulatory domain

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000534044

376_397

565.0

604.0

Region

Note=Leucine-zipper

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000534121

275_327

707.0

746.0

Region

Transcription activation domain (PubMed:2189102)

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000534121

328_465

707.0

746.0

Region

Negative regulatory domain

Tgene

MYB

chr6:149208165

chr6:135539002

ENST00000534121

376_397

707.0

746.0

Region

Note=Leucine-zipper

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

MYB

PML, SMARCA2, CREBBP, NCL, CEBPB, CEBPE, MAF, SND1, PAX5, FBXW7, ZMYND11, KMT2A, WDR5, RBBP5, ASH2L, MEN1, NLK, HIPK2, HLF, SP100, PARP1, EP300, TRIM28, SKI, SIN3A, NCOR1, UBE2I, CHD3, KAT2B, RPL4, LEF1, Fbxw7, KAT5, GATA3, STAT5A, TRAF6, FBXW5, DDB1, CUL4A, PIAS1, RBX1, SUMO1, SUMO2, CCND3, MYOZ2, PPM1K, ERC2, UPF2, KAT2A, HSPA8, HIST3H3, HIST1H2AB, HIST1H2BB, HIST1H3A, HIST1H4A, KIAA1429, DCAF15, APEX1, PAIP1, UPF1, BMI1, DDX39A, SETD1A, LIN9, KMT2D, E2F6, HIVEP1, YY1, CTCF, ZNF131, BLM, ZBTB33, PHF6, PCGF6, EHMT1, TRPS1, KMT2B, ZNF148, ZEB2, ZEB1, CUX1, ARID3A, ZNF536, RAD21, WIZ, NR2C1, RPL34, ATXN1, MLLT6, RPL37A, NFIA, RLF, TAF9, GPATCH4, BEND3, ZMYM4, NIPBL, ZNF66, PAXIP1, KANSL1, POGZ, C11orf30, ARID3B, MGA, ZNF709, KDM2B, GATAD1, BAP1, L3MBTL2, ZBTB9, ZBTB10, EHMT2, CIC, ZNF644, CXXC1, CHD7, KANSL3, DACH1, PHF8, SATB2, SMC3, ZNF281, NOP16,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
UST
MYB

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	MYB	chr6:149208165	chr6:135539001	ENST00000341911		14	16	90_193	723.0	762.0	HIPK2 and NLK
Tgene	MYB	chr6:149208165	chr6:135539001	ENST00000367814		13	15	90_193	602.0	641.0	HIPK2 and NLK
Tgene	MYB	chr6:149208165	chr6:135539001	ENST00000442647		13	15	90_193	599.0	638.0	HIPK2 and NLK
Tgene	MYB	chr6:149208165	chr6:135539001	ENST00000525369		12	14	90_193	517.0	556.0	HIPK2 and NLK
Tgene	MYB	chr6:149208165	chr6:135539001	ENST00000528774		14	16	90_193	720.0	759.0	HIPK2 and NLK
Tgene	MYB	chr6:149208165	chr6:135539001	ENST00000533624		12	14	90_193	567.0	606.0	HIPK2 and NLK
Tgene	MYB	chr6:149208165	chr6:135539001	ENST00000534044		12	14	90_193	565.0	604.0	HIPK2 and NLK
Tgene	MYB	chr6:149208165	chr6:135539001	ENST00000534121		14	16	90_193	707.0	746.0	HIPK2 and NLK
Tgene	MYB	chr6:149208165	chr6:135539002	ENST00000341911		14	16	90_193	723.0	762.0	HIPK2 and NLK
Tgene	MYB	chr6:149208165	chr6:135539002	ENST00000367814		13	15	90_193	602.0	641.0	HIPK2 and NLK
Tgene	MYB	chr6:149208165	chr6:135539002	ENST00000442647		13	15	90_193	599.0	638.0	HIPK2 and NLK
Tgene	MYB	chr6:149208165	chr6:135539002	ENST00000525369		12	14	90_193	517.0	556.0	HIPK2 and NLK
Tgene	MYB	chr6:149208165	chr6:135539002	ENST00000528774		14	16	90_193	720.0	759.0	HIPK2 and NLK
Tgene	MYB	chr6:149208165	chr6:135539002	ENST00000533624		12	14	90_193	567.0	606.0	HIPK2 and NLK
Tgene	MYB	chr6:149208165	chr6:135539002	ENST00000534044		12	14	90_193	565.0	604.0	HIPK2 and NLK
Tgene	MYB	chr6:149208165	chr6:135539002	ENST00000534121		14	16	90_193	707.0	746.0	HIPK2 and NLK

Top

Related Drugs to UST-MYB

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to UST-MYB

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	MYB	C0010606	Adenoid Cystic Carcinoma	2	CTD_human
Tgene	MYB	C0017638	Glioma	2	CTD_human
Tgene	MYB	C0259783	mixed gliomas	2	CTD_human
Tgene	MYB	C0555198	Malignant Glioma	2	CTD_human
Tgene	MYB	C1961099	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2	CTD_human;ORPHANET
Tgene	MYB	C0004096	Asthma	1	CTD_human
Tgene	MYB	C0023437	Acute Basophilic Leukemia	1	ORPHANET
Tgene	MYB	C2363903	Angiocentric glioma	1	ORPHANET