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Fusion Protein:UVRAG-INTS4 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: UVRAG-INTS4 | FusionPDB ID: 97792 | FusionGDB2.0 ID: 97792 | Hgene | Tgene | Gene symbol | UVRAG | INTS4 | Gene ID | 7405 | 92105 |
Gene name | UV radiation resistance associated | integrator complex subunit 4 | |
Synonyms | DHTX|VPS38|p63 | INT4|MST093 | |
Cytomap | 11q13.5 | 11q14.1 | |
Type of gene | protein-coding | protein-coding | |
Description | UV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxy | integrator complex subunit 4MSTP093 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | Q96HW7 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000525872, ENST00000356136, ENST00000528420, ENST00000531818, ENST00000532130, ENST00000533454, ENST00000538870, ENST00000539288, | ENST00000534064, ENST00000535943, ENST00000525931, ENST00000527522, ENST00000529807, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 41 X 18 X 15=11070 | 13 X 9 X 8=936 |
# samples | 49 | 16 | |
** MAII score | log2(49/11070*10)=-4.49772966266634 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/936*10)=-2.54843662469604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: UVRAG [Title/Abstract] AND INTS4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | UVRAG(75623083)-INTS4(77618856), # samples:4 | ||
Anticipated loss of major functional domain due to fusion event. | UVRAG-INTS4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. UVRAG-INTS4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. UVRAG-INTS4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. UVRAG-INTS4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | UVRAG | GO:0071900 | regulation of protein serine/threonine kinase activity | 22542840 |
Hgene | UVRAG | GO:0097352 | autophagosome maturation | 28306502 |
Hgene | UVRAG | GO:0097680 | double-strand break repair via classical nonhomologous end joining | 22542840 |
Tgene | INTS4 | GO:0016180 | snRNA processing | 16239144 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-A1-A0SJ-01A | UVRAG | chr11 | 75623083 | - | INTS4 | chr11 | 77618856 | - |
ChimerDB4 | BRCA | TCGA-A1-A0SJ-01A | UVRAG | chr11 | 75623083 | + | INTS4 | chr11 | 77618856 | - |
ChimerDB4 | BRCA | TCGA-A1-A0SJ | UVRAG | chr11 | 75623083 | + | INTS4 | chr11 | 77618856 | - |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000356136 | UVRAG | chr11 | 75623083 | + | ENST00000534064 | INTS4 | chr11 | 77618856 | - | 2033 | 834 | 163 | 1803 | 546 |
ENST00000356136 | UVRAG | chr11 | 75623083 | + | ENST00000535943 | INTS4 | chr11 | 77618856 | - | 2031 | 834 | 163 | 1803 | 546 |
ENST00000528420 | UVRAG | chr11 | 75623083 | + | ENST00000534064 | INTS4 | chr11 | 77618856 | - | 1774 | 575 | 96 | 1544 | 482 |
ENST00000528420 | UVRAG | chr11 | 75623083 | + | ENST00000535943 | INTS4 | chr11 | 77618856 | - | 1772 | 575 | 96 | 1544 | 482 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000356136 | ENST00000534064 | UVRAG | chr11 | 75623083 | + | INTS4 | chr11 | 77618856 | - | 0.002299417 | 0.99770063 |
ENST00000356136 | ENST00000535943 | UVRAG | chr11 | 75623083 | + | INTS4 | chr11 | 77618856 | - | 0.002293658 | 0.9977063 |
ENST00000528420 | ENST00000534064 | UVRAG | chr11 | 75623083 | + | INTS4 | chr11 | 77618856 | - | 0.001906639 | 0.9980933 |
ENST00000528420 | ENST00000535943 | UVRAG | chr11 | 75623083 | + | INTS4 | chr11 | 77618856 | - | 0.001907803 | 0.99809223 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >97792_97792_1_UVRAG-INTS4_UVRAG_chr11_75623083_ENST00000356136_INTS4_chr11_77618856_ENST00000534064_length(amino acids)=546AA_BP=250 MVGGGKGAAADAGRVPAPPLGGPWIEMSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDT YFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLLIEWKVCLDGLKYLGQQIHARNQNEII FGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFSLLRDLQRLGELQSELAGVADFSATYLRCQLLLIKALQEKLWNVAAPLYL KQSDLASAAAKQIMEETYKMEFMYSGVENKQVVIIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFV DKLLDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSGLVVALDVDATLEHVQDPQNTVKVQVLY PDGQAQMIHPKPADFRNPGPGRHRLITQVYLSHTAWTEACQVEVRLLLAYNSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIM -------------------------------------------------------------- >97792_97792_2_UVRAG-INTS4_UVRAG_chr11_75623083_ENST00000356136_INTS4_chr11_77618856_ENST00000535943_length(amino acids)=546AA_BP=250 MVGGGKGAAADAGRVPAPPLGGPWIEMSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDT YFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLLIEWKVCLDGLKYLGQQIHARNQNEII FGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFSLLRDLQRLGELQSELAGVADFSATYLRCQLLLIKALQEKLWNVAAPLYL KQSDLASAAAKQIMEETYKMEFMYSGVENKQVVIIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFV DKLLDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSGLVVALDVDATLEHVQDPQNTVKVQVLY PDGQAQMIHPKPADFRNPGPGRHRLITQVYLSHTAWTEACQVEVRLLLAYNSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIM -------------------------------------------------------------- >97792_97792_3_UVRAG-INTS4_UVRAG_chr11_75623083_ENST00000528420_INTS4_chr11_77618856_ENST00000534064_length(amino acids)=482AA_BP=186 MRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLL IEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFSLLRDLQRLGELQSELAGVADFSA TYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVVIIHHMRLQAKALQLIVTARTTRGLDPLFGMC EKFLQEVDFFQRYFIADLPHLQDSFVDKLLDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSGL VVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSHTAWTEACQVEVRLLLAYNSSARIPKCPWMEG -------------------------------------------------------------- >97792_97792_4_UVRAG-INTS4_UVRAG_chr11_75623083_ENST00000528420_INTS4_chr11_77618856_ENST00000535943_length(amino acids)=482AA_BP=186 MRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLL IEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFSLLRDLQRLGELQSELAGVADFSA TYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVVIIHHMRLQAKALQLIVTARTTRGLDPLFGMC EKFLQEVDFFQRYFIADLPHLQDSFVDKLLDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSGL VVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSHTAWTEACQVEVRLLLAYNSSARIPKCPWMEG -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:75623083/chr11:77618856) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | INTS4 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | UVRAG | chr11:75623083 | chr11:77618856 | ENST00000356136 | + | 6 | 15 | 23_149 | 197.66666666666666 | 700.0 | Domain | C2 |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000529807 | 0 | 12 | 145_183 | 0 | 506.0 | Repeat | Note=HEAT 2 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000529807 | 0 | 12 | 190_228 | 0 | 506.0 | Repeat | Note=HEAT 3 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000529807 | 0 | 12 | 229_263 | 0 | 506.0 | Repeat | Note=HEAT 4 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000529807 | 0 | 12 | 277_313 | 0 | 506.0 | Repeat | Note=HEAT 5 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000529807 | 0 | 12 | 369_405 | 0 | 506.0 | Repeat | Note=HEAT 6 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000529807 | 0 | 12 | 406_444 | 0 | 506.0 | Repeat | Note=HEAT 7 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000529807 | 0 | 12 | 446_484 | 0 | 506.0 | Repeat | Note=HEAT 8 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000529807 | 0 | 12 | 66_105 | 0 | 506.0 | Repeat | Note=HEAT 1 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000535943 | 0 | 9 | 145_183 | 15.666666666666666 | 339.0 | Repeat | Note=HEAT 2 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000535943 | 0 | 9 | 190_228 | 15.666666666666666 | 339.0 | Repeat | Note=HEAT 3 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000535943 | 0 | 9 | 229_263 | 15.666666666666666 | 339.0 | Repeat | Note=HEAT 4 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000535943 | 0 | 9 | 277_313 | 15.666666666666666 | 339.0 | Repeat | Note=HEAT 5 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000535943 | 0 | 9 | 369_405 | 15.666666666666666 | 339.0 | Repeat | Note=HEAT 6 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000535943 | 0 | 9 | 406_444 | 15.666666666666666 | 339.0 | Repeat | Note=HEAT 7 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000535943 | 0 | 9 | 446_484 | 15.666666666666666 | 339.0 | Repeat | Note=HEAT 8 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000535943 | 0 | 9 | 66_105 | 15.666666666666666 | 339.0 | Repeat | Note=HEAT 1 |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | UVRAG | chr11:75623083 | chr11:77618856 | ENST00000356136 | + | 6 | 15 | 224_305 | 197.66666666666666 | 700.0 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000534064 | 14 | 23 | 145_183 | 640.6666666666666 | 964.0 | Repeat | Note=HEAT 2 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000534064 | 14 | 23 | 190_228 | 640.6666666666666 | 964.0 | Repeat | Note=HEAT 3 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000534064 | 14 | 23 | 229_263 | 640.6666666666666 | 964.0 | Repeat | Note=HEAT 4 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000534064 | 14 | 23 | 277_313 | 640.6666666666666 | 964.0 | Repeat | Note=HEAT 5 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000534064 | 14 | 23 | 369_405 | 640.6666666666666 | 964.0 | Repeat | Note=HEAT 6 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000534064 | 14 | 23 | 406_444 | 640.6666666666666 | 964.0 | Repeat | Note=HEAT 7 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000534064 | 14 | 23 | 446_484 | 640.6666666666666 | 964.0 | Repeat | Note=HEAT 8 | |
Tgene | INTS4 | chr11:75623083 | chr11:77618856 | ENST00000534064 | 14 | 23 | 66_105 | 640.6666666666666 | 964.0 | Repeat | Note=HEAT 1 |
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Fusion Protein Structures |
![]() * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
PDB file >>>1169_UVRAG_75623083_INTS4_77618856_1169_UVRAG_75623083_INTS4_77618856_ranked_0.pdb | UVRAG | 75623083 | 75623083 | ENST00000535943 | INTS4 | chr11 | 77618856 | - | MVGGGKGAAADAGRVPAPPLGGPWIEMSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDT YFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLLIEWKVCLDGLKYLGQQIHARNQNEII FGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFSLLRDLQRLGELQSELAGVADFSATYLRCQLLLIKALQEKLWNVAAPLYL KQSDLASAAAKQIMEETYKMEFMYSGVENKQVVIIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFV DKLLDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSGLVVALDVDATLEHVQDPQNTVKVQVLY PDGQAQMIHPKPADFRNPGPGRHRLITQVYLSHTAWTEACQVEVRLLLAYNSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIM | 546 |
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pLDDT score distribution |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
UVRAG_pLDDT.png![]() |
INTS4_pLDDT.png![]() |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
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Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
UVRAG | |
INTS4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to UVRAG-INTS4 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to UVRAG-INTS4 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |