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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:UVRAG-MAP6

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: UVRAG-MAP6
FusionPDB ID: 97798
FusionGDB2.0 ID: 97798
HgeneTgene
Gene symbol

UVRAG

MAP6

Gene ID

7405

4135

Gene nameUV radiation resistance associatedmicrotubule associated protein 6
SynonymsDHTX|VPS38|p63MAP6-N|MTAP6|N-STOP|STOP
Cytomap

11q13.5

11q13.5

Type of geneprotein-codingprotein-coding
DescriptionUV radiation resistance-associated gene proteinbeclin 1 binding proteindisrupted in heterotaxymicrotubule-associated protein 6CTD-2530H12.7MAP-6stable tubule-only polypeptide
Modification date2020031320200313
UniProtAcc.

Q96JE9

Ensembl transtripts involved in fusion geneENST idsENST00000525872, ENST00000356136, 
ENST00000528420, ENST00000533454, 
ENST00000531818, ENST00000532130, 
ENST00000538870, ENST00000539288, 
ENST00000304771, ENST00000434603, 
ENST00000526740, ENST00000526689, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score41 X 18 X 15=110704 X 4 X 4=64
# samples 497
** MAII scorelog2(49/11070*10)=-4.49772966266634
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/64*10)=0.129283016944966
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: UVRAG [Title/Abstract] AND MAP6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)UVRAG(75526569)-MAP6(75317049), # samples:4
Anticipated loss of major functional domain due to fusion event.UVRAG-MAP6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
UVRAG-MAP6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
UVRAG-MAP6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
UVRAG-MAP6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
UVRAG-MAP6 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
UVRAG-MAP6 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
UVRAG-MAP6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUVRAG

GO:0071900

regulation of protein serine/threonine kinase activity

22542840

HgeneUVRAG

GO:0097352

autophagosome maturation

28306502

HgeneUVRAG

GO:0097680

double-strand break repair via classical nonhomologous end joining

22542840


check buttonFusion gene breakpoints across UVRAG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAP6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A03Y-01AUVRAGchr11

75623083

+MAP6chr11

75319367

-
ChimerDB4BRCATCGA-AN-A03Y-01AUVRAGchr11

75672593

+MAP6chr11

75299229

-
ChimerDB4BRCATCGA-AN-A03Y-01AUVRAGchr11

75672593

-MAP6chr11

75319367

-
ChimerDB4BRCATCGA-AN-A03Y-01AUVRAGchr11

75672593

+MAP6chr11

75319367

-
ChimerDB4BRCATCGA-AN-A03YUVRAGchr11

75623083

+MAP6chr11

75319367

-
ChimerDB4BRCATCGA-D8-A1JC-01AUVRAGchr11

75526569

-MAP6chr11

75319367

-
ChimerDB4BRCATCGA-D8-A1JC-01AUVRAGchr11

75526569

+MAP6chr11

75319367

-
ChimerDB4BRCATCGA-D8-A1JCUVRAGchr11

75526569

+MAP6chr11

75319367

-
ChimerDB4STADTCGA-RD-A8N4-01AUVRAGchr11

75526569

+MAP6chr11

75299229

-
ChimerDB4STADTCGA-RD-A8N4-01AUVRAGchr11

75526569

-MAP6chr11

75317049

-
ChimerDB4STADTCGA-RD-A8N4-01AUVRAGchr11

75526569

+MAP6chr11

75317049

-
ChimerDB4STADTCGA-RD-A8N4UVRAGchr11

75526569

+MAP6chr11

75299229

-
ChimerDB4STADTCGA-RD-A8N4UVRAGchr11

75526569

+MAP6chr11

75317049

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356136UVRAGchr1175623083+ENST00000304771MAP6chr1175319367-25128341632370735
ENST00000528420UVRAGchr1175623083+ENST00000304771MAP6chr1175319367-2253575962111671
ENST00000356136UVRAGchr1175526569+ENST00000304771MAP6chr1175317049-18223581631680505
ENST00000356136UVRAGchr1175526569+ENST00000526740MAP6chr1175317049-18213581631680505
ENST00000356136UVRAGchr1175526569+ENST00000434603MAP6chr1175317049-35033587591223154
ENST00000356136UVRAGchr1175526569+ENST00000304771MAP6chr1175299229-16253582991483394
ENST00000356136UVRAGchr1175526569+ENST00000526740MAP6chr1175299229-16243582991483394
ENST00000356136UVRAGchr1175672593+ENST00000304771MAP6chr1175299229-22079409322065377
ENST00000356136UVRAGchr1175672593+ENST00000526740MAP6chr1175299229-22069409322065377
ENST00000528420UVRAGchr1175672593+ENST00000304771MAP6chr1175299229-19486816731806377
ENST00000528420UVRAGchr1175672593+ENST00000526740MAP6chr1175299229-19476816731806377

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356136ENST00000304771UVRAGchr1175623083+MAP6chr1175319367-0.001568420.9984315
ENST00000528420ENST00000304771UVRAGchr1175623083+MAP6chr1175319367-0.0015131190.9984869
ENST00000356136ENST00000304771UVRAGchr1175526569+MAP6chr1175317049-0.0027652250.99723476
ENST00000356136ENST00000526740UVRAGchr1175526569+MAP6chr1175317049-0.0027529130.99724704
ENST00000356136ENST00000434603UVRAGchr1175526569+MAP6chr1175317049-0.468452070.53154796
ENST00000356136ENST00000304771UVRAGchr1175526569+MAP6chr1175299229-0.0015329180.998467
ENST00000356136ENST00000526740UVRAGchr1175526569+MAP6chr1175299229-0.0015272890.99847275
ENST00000356136ENST00000304771UVRAGchr1175672593+MAP6chr1175299229-0.0017164520.9982836
ENST00000356136ENST00000526740UVRAGchr1175672593+MAP6chr1175299229-0.001708070.9982919
ENST00000528420ENST00000304771UVRAGchr1175672593+MAP6chr1175299229-0.0013195630.9986804
ENST00000528420ENST00000526740UVRAGchr1175672593+MAP6chr1175299229-0.0013045710.99869543

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>97798_97798_1_UVRAG-MAP6_UVRAG_chr11_75526569_ENST00000356136_MAP6_chr11_75299229_ENST00000304771_length(amino acids)=394AA_BP=47
MLCLPVLPRGPCMWSCRLSRSLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDLGPMIPLPVKDQDH
TVPEPLKNESPVISAPVKDQGPSVPVPPKNQSPMVPAKVKDQGSVVPESLKDQGPRIPEPVKNQAPMVPAPVKDEGPMVSASVKDQGPMV
SAPVKDQGPIVPAPVKGEGPIVPAPVKDEGPMVSAPIKDQDPMVPEHPKDESAMATAPIKNQGSMVSEPVKNQGLVVSGPVKDQDVVVPE
HAKVHDSAVVAPVKNQGPVVPESVKNQDPILPVLVKDQGPTVLQPPKNQGRIVPEPLKNQVPIVPVPLKDQDPLVPVPAKDQGPAVPEPL

--------------------------------------------------------------

>97798_97798_2_UVRAG-MAP6_UVRAG_chr11_75526569_ENST00000356136_MAP6_chr11_75299229_ENST00000526740_length(amino acids)=394AA_BP=47
MLCLPVLPRGPCMWSCRLSRSLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDLGPMIPLPVKDQDH
TVPEPLKNESPVISAPVKDQGPSVPVPPKNQSPMVPAKVKDQGSVVPESLKDQGPRIPEPVKNQAPMVPAPVKDEGPMVSASVKDQGPMV
SAPVKDQGPIVPAPVKGEGPIVPAPVKDEGPMVSAPIKDQDPMVPEHPKDESAMATAPIKNQGSMVSEPVKNQGLVVSGPVKDQDVVVPE
HAKVHDSAVVAPVKNQGPVVPESVKNQDPILPVLVKDQGPTVLQPPKNQGRIVPEPLKNQVPIVPVPLKDQDPLVPVPAKDQGPAVPEPL

--------------------------------------------------------------

>97798_97798_3_UVRAG-MAP6_UVRAG_chr11_75526569_ENST00000356136_MAP6_chr11_75317049_ENST00000304771_length(amino acids)=505AA_BP=158
MVGGGKGAAADAGRVPAPPLGGPWIEMSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQVEKPSVQSSKPKKTSASHKPTRKAK
DKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEAKESLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSV
VPGPPKDLGPMIPLPVKDQDHTVPEPLKNESPVISAPVKDQGPSVPVPPKNQSPMVPAKVKDQGSVVPESLKDQGPRIPEPVKNQAPMVP
APVKDEGPMVSASVKDQGPMVSAPVKDQGPIVPAPVKGEGPIVPAPVKDEGPMVSAPIKDQDPMVPEHPKDESAMATAPIKNQGSMVSEP
VKNQGLVVSGPVKDQDVVVPEHAKVHDSAVVAPVKNQGPVVPESVKNQDPILPVLVKDQGPTVLQPPKNQGRIVPEPLKNQVPIVPVPLK

--------------------------------------------------------------

>97798_97798_4_UVRAG-MAP6_UVRAG_chr11_75526569_ENST00000356136_MAP6_chr11_75317049_ENST00000434603_length(amino acids)=154AA_BP=
MRAAPGAPGSVAAGCALPWHSDCMLMSKAGRSERRNESPGSAWKCLWGLLLPDPQDLCHWSILNFRYMCSFQKFRESSCATEAQPGLQQL

--------------------------------------------------------------

>97798_97798_5_UVRAG-MAP6_UVRAG_chr11_75526569_ENST00000356136_MAP6_chr11_75317049_ENST00000526740_length(amino acids)=505AA_BP=158
MVGGGKGAAADAGRVPAPPLGGPWIEMSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQVEKPSVQSSKPKKTSASHKPTRKAK
DKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEAKESLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSV
VPGPPKDLGPMIPLPVKDQDHTVPEPLKNESPVISAPVKDQGPSVPVPPKNQSPMVPAKVKDQGSVVPESLKDQGPRIPEPVKNQAPMVP
APVKDEGPMVSASVKDQGPMVSAPVKDQGPIVPAPVKGEGPIVPAPVKDEGPMVSAPIKDQDPMVPEHPKDESAMATAPIKNQGSMVSEP
VKNQGLVVSGPVKDQDVVVPEHAKVHDSAVVAPVKNQGPVVPESVKNQDPILPVLVKDQGPTVLQPPKNQGRIVPEPLKNQVPIVPVPLK

--------------------------------------------------------------

>97798_97798_6_UVRAG-MAP6_UVRAG_chr11_75623083_ENST00000356136_MAP6_chr11_75319367_ENST00000304771_length(amino acids)=735AA_BP=388
MVGGGKGAAADAGRVPAPPLGGPWIEMSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDT
YFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLLIEWKVCLDGLKYLGQQIHARNQNEII
FGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFSLLRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPT
TADNKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEAK
ESLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDLGPMIPLPVKDQDHTVPEPLKNESPVISAPVKD
QGPSVPVPPKNQSPMVPAKVKDQGSVVPESLKDQGPRIPEPVKNQAPMVPAPVKDEGPMVSASVKDQGPMVSAPVKDQGPIVPAPVKGEG
PIVPAPVKDEGPMVSAPIKDQDPMVPEHPKDESAMATAPIKNQGSMVSEPVKNQGLVVSGPVKDQDVVVPEHAKVHDSAVVAPVKNQGPV
VPESVKNQDPILPVLVKDQGPTVLQPPKNQGRIVPEPLKNQVPIVPVPLKDQDPLVPVPAKDQGPAVPEPLKTQGPRDPQLPTVSPLPRV

--------------------------------------------------------------

>97798_97798_7_UVRAG-MAP6_UVRAG_chr11_75623083_ENST00000528420_MAP6_chr11_75319367_ENST00000304771_length(amino acids)=671AA_BP=324
MRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLL
IEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFSLLRNEFRAWTDIKPVKPIKAKPQ
YKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKS
AEGPSTTKPDDKEQSKEMNNKLAEAKESLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDLGPMIPL
PVKDQDHTVPEPLKNESPVISAPVKDQGPSVPVPPKNQSPMVPAKVKDQGSVVPESLKDQGPRIPEPVKNQAPMVPAPVKDEGPMVSASV
KDQGPMVSAPVKDQGPIVPAPVKGEGPIVPAPVKDEGPMVSAPIKDQDPMVPEHPKDESAMATAPIKNQGSMVSEPVKNQGLVVSGPVKD
QDVVVPEHAKVHDSAVVAPVKNQGPVVPESVKNQDPILPVLVKDQGPTVLQPPKNQGRIVPEPLKNQVPIVPVPLKDQDPLVPVPAKDQG

--------------------------------------------------------------

>97798_97798_8_UVRAG-MAP6_UVRAG_chr11_75672593_ENST00000356136_MAP6_chr11_75299229_ENST00000304771_length(amino acids)=377AA_BP=30
MNWSLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDLGPMIPLPVKDQDHTVPEPLKNESPVISAPV
KDQGPSVPVPPKNQSPMVPAKVKDQGSVVPESLKDQGPRIPEPVKNQAPMVPAPVKDEGPMVSASVKDQGPMVSAPVKDQGPIVPAPVKG
EGPIVPAPVKDEGPMVSAPIKDQDPMVPEHPKDESAMATAPIKNQGSMVSEPVKNQGLVVSGPVKDQDVVVPEHAKVHDSAVVAPVKNQG
PVVPESVKNQDPILPVLVKDQGPTVLQPPKNQGRIVPEPLKNQVPIVPVPLKDQDPLVPVPAKDQGPAVPEPLKTQGPRDPQLPTVSPLP

--------------------------------------------------------------

>97798_97798_9_UVRAG-MAP6_UVRAG_chr11_75672593_ENST00000356136_MAP6_chr11_75299229_ENST00000526740_length(amino acids)=377AA_BP=30
MNWSLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDLGPMIPLPVKDQDHTVPEPLKNESPVISAPV
KDQGPSVPVPPKNQSPMVPAKVKDQGSVVPESLKDQGPRIPEPVKNQAPMVPAPVKDEGPMVSASVKDQGPMVSAPVKDQGPIVPAPVKG
EGPIVPAPVKDEGPMVSAPIKDQDPMVPEHPKDESAMATAPIKNQGSMVSEPVKNQGLVVSGPVKDQDVVVPEHAKVHDSAVVAPVKNQG
PVVPESVKNQDPILPVLVKDQGPTVLQPPKNQGRIVPEPLKNQVPIVPVPLKDQDPLVPVPAKDQGPAVPEPLKTQGPRDPQLPTVSPLP

--------------------------------------------------------------

>97798_97798_10_UVRAG-MAP6_UVRAG_chr11_75672593_ENST00000528420_MAP6_chr11_75299229_ENST00000304771_length(amino acids)=377AA_BP=30
MNWSLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDLGPMIPLPVKDQDHTVPEPLKNESPVISAPV
KDQGPSVPVPPKNQSPMVPAKVKDQGSVVPESLKDQGPRIPEPVKNQAPMVPAPVKDEGPMVSASVKDQGPMVSAPVKDQGPIVPAPVKG
EGPIVPAPVKDEGPMVSAPIKDQDPMVPEHPKDESAMATAPIKNQGSMVSEPVKNQGLVVSGPVKDQDVVVPEHAKVHDSAVVAPVKNQG
PVVPESVKNQDPILPVLVKDQGPTVLQPPKNQGRIVPEPLKNQVPIVPVPLKDQDPLVPVPAKDQGPAVPEPLKTQGPRDPQLPTVSPLP

--------------------------------------------------------------

>97798_97798_11_UVRAG-MAP6_UVRAG_chr11_75672593_ENST00000528420_MAP6_chr11_75299229_ENST00000526740_length(amino acids)=377AA_BP=30
MNWSLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDLGPMIPLPVKDQDHTVPEPLKNESPVISAPV
KDQGPSVPVPPKNQSPMVPAKVKDQGSVVPESLKDQGPRIPEPVKNQAPMVPAPVKDEGPMVSASVKDQGPMVSAPVKDQGPIVPAPVKG
EGPIVPAPVKDEGPMVSAPIKDQDPMVPEHPKDESAMATAPIKNQGSMVSEPVKNQGLVVSGPVKDQDVVVPEHAKVHDSAVVAPVKNQG
PVVPESVKNQDPILPVLVKDQGPTVLQPPKNQGRIVPEPLKNQVPIVPVPLKDQDPLVPVPAKDQGPAVPEPLKTQGPRDPQLPTVSPLP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:75526569/chr11:75317049)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAP6

Q96JE9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity). {ECO:0000250|UniProtKB:Q63560, ECO:0000269|PubMed:24357581}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUVRAGchr11:75623083chr11:75319367ENST00000356136+61523_149197.66666666666666700.0DomainC2
HgeneUVRAGchr11:75672593chr11:75299229ENST00000356136+71523_149233.0700.0DomainC2
TgeneMAP6chr11:75526569chr11:75299229ENST0000030477124490_804438.6666666666667814.0Compositional biasNote=Pro-rich
TgeneMAP6chr11:75526569chr11:75299229ENST000004346030343_490440.0Compositional biasNote=Poly-Pro
TgeneMAP6chr11:75526569chr11:75299229ENST0000043460303490_8040440.0Compositional biasNote=Pro-rich
TgeneMAP6chr11:75526569chr11:75317049ENST0000030477114490_804373.0814.0Compositional biasNote=Pro-rich
TgeneMAP6chr11:75526569chr11:75317049ENST0000043460313490_804373.0440.0Compositional biasNote=Pro-rich
TgeneMAP6chr11:75623083chr11:75319367ENST0000030477104490_804301.6666666666667814.0Compositional biasNote=Pro-rich
TgeneMAP6chr11:75623083chr11:75319367ENST0000043460303490_804301.6666666666667440.0Compositional biasNote=Pro-rich
TgeneMAP6chr11:75672593chr11:75299229ENST0000030477124490_804438.6666666666667814.0Compositional biasNote=Pro-rich
TgeneMAP6chr11:75672593chr11:75299229ENST000004346030343_490440.0Compositional biasNote=Poly-Pro
TgeneMAP6chr11:75672593chr11:75299229ENST0000043460303490_8040440.0Compositional biasNote=Pro-rich
TgeneMAP6chr11:75526569chr11:75299229ENST0000043460303118_1410440.0RegionMn 1
TgeneMAP6chr11:75526569chr11:75299229ENST0000043460303126_1400440.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75299229ENST0000043460303153_1760440.0RegionMn 2
TgeneMAP6chr11:75526569chr11:75299229ENST0000043460303162_1760440.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75299229ENST0000043460303189_2030440.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75299229ENST0000043460303298_3210440.0RegionMn 3
TgeneMAP6chr11:75526569chr11:75299229ENST0000043460303306_3200440.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75299229ENST0000043460303357_3710440.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75299229ENST0000043460303384_3980440.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST0000030477114384_398373.0814.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST0000043460313384_398373.0440.0RegionCalmodulin-binding
TgeneMAP6chr11:75623083chr11:75319367ENST0000030477104306_320301.6666666666667814.0RegionCalmodulin-binding
TgeneMAP6chr11:75623083chr11:75319367ENST0000030477104357_371301.6666666666667814.0RegionCalmodulin-binding
TgeneMAP6chr11:75623083chr11:75319367ENST0000030477104384_398301.6666666666667814.0RegionCalmodulin-binding
TgeneMAP6chr11:75623083chr11:75319367ENST0000043460303306_320301.6666666666667440.0RegionCalmodulin-binding
TgeneMAP6chr11:75623083chr11:75319367ENST0000043460303357_371301.6666666666667440.0RegionCalmodulin-binding
TgeneMAP6chr11:75623083chr11:75319367ENST0000043460303384_398301.6666666666667440.0RegionCalmodulin-binding
TgeneMAP6chr11:75672593chr11:75299229ENST0000043460303118_1410440.0RegionMn 1
TgeneMAP6chr11:75672593chr11:75299229ENST0000043460303126_1400440.0RegionCalmodulin-binding
TgeneMAP6chr11:75672593chr11:75299229ENST0000043460303153_1760440.0RegionMn 2
TgeneMAP6chr11:75672593chr11:75299229ENST0000043460303162_1760440.0RegionCalmodulin-binding
TgeneMAP6chr11:75672593chr11:75299229ENST0000043460303189_2030440.0RegionCalmodulin-binding
TgeneMAP6chr11:75672593chr11:75299229ENST0000043460303298_3210440.0RegionMn 3
TgeneMAP6chr11:75672593chr11:75299229ENST0000043460303306_3200440.0RegionCalmodulin-binding
TgeneMAP6chr11:75672593chr11:75299229ENST0000043460303357_3710440.0RegionCalmodulin-binding
TgeneMAP6chr11:75672593chr11:75299229ENST0000043460303384_3980440.0RegionCalmodulin-binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneUVRAGchr11:75526569chr11:75299229ENST00000356136+115224_30539.0700.0Coiled coilOntology_term=ECO:0000255
HgeneUVRAGchr11:75526569chr11:75317049ENST00000356136+115224_30539.0700.0Coiled coilOntology_term=ECO:0000255
HgeneUVRAGchr11:75623083chr11:75319367ENST00000356136+615224_305197.66666666666666700.0Coiled coilOntology_term=ECO:0000255
HgeneUVRAGchr11:75672593chr11:75299229ENST00000356136+715224_305233.0700.0Coiled coilOntology_term=ECO:0000255
HgeneUVRAGchr11:75526569chr11:75299229ENST00000356136+11523_14939.0700.0DomainC2
HgeneUVRAGchr11:75526569chr11:75317049ENST00000356136+11523_14939.0700.0DomainC2
TgeneMAP6chr11:75526569chr11:75299229ENST000003047712443_49438.6666666666667814.0Compositional biasNote=Poly-Pro
TgeneMAP6chr11:75526569chr11:75317049ENST000003047711443_49373.0814.0Compositional biasNote=Poly-Pro
TgeneMAP6chr11:75526569chr11:75317049ENST000004346031343_49373.0440.0Compositional biasNote=Poly-Pro
TgeneMAP6chr11:75623083chr11:75319367ENST000003047710443_49301.6666666666667814.0Compositional biasNote=Poly-Pro
TgeneMAP6chr11:75623083chr11:75319367ENST000004346030343_49301.6666666666667440.0Compositional biasNote=Poly-Pro
TgeneMAP6chr11:75672593chr11:75299229ENST000003047712443_49438.6666666666667814.0Compositional biasNote=Poly-Pro
TgeneMAP6chr11:75526569chr11:75299229ENST0000030477124118_141438.6666666666667814.0RegionMn 1
TgeneMAP6chr11:75526569chr11:75299229ENST0000030477124126_140438.6666666666667814.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75299229ENST0000030477124153_176438.6666666666667814.0RegionMn 2
TgeneMAP6chr11:75526569chr11:75299229ENST0000030477124162_176438.6666666666667814.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75299229ENST0000030477124189_203438.6666666666667814.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75299229ENST0000030477124298_321438.6666666666667814.0RegionMn 3
TgeneMAP6chr11:75526569chr11:75299229ENST0000030477124306_320438.6666666666667814.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75299229ENST0000030477124357_371438.6666666666667814.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75299229ENST0000030477124384_398438.6666666666667814.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST0000030477114118_141373.0814.0RegionMn 1
TgeneMAP6chr11:75526569chr11:75317049ENST0000030477114126_140373.0814.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST0000030477114153_176373.0814.0RegionMn 2
TgeneMAP6chr11:75526569chr11:75317049ENST0000030477114162_176373.0814.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST0000030477114189_203373.0814.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST0000030477114298_321373.0814.0RegionMn 3
TgeneMAP6chr11:75526569chr11:75317049ENST0000030477114306_320373.0814.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST0000030477114357_371373.0814.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST0000043460313118_141373.0440.0RegionMn 1
TgeneMAP6chr11:75526569chr11:75317049ENST0000043460313126_140373.0440.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST0000043460313153_176373.0440.0RegionMn 2
TgeneMAP6chr11:75526569chr11:75317049ENST0000043460313162_176373.0440.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST0000043460313189_203373.0440.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST0000043460313298_321373.0440.0RegionMn 3
TgeneMAP6chr11:75526569chr11:75317049ENST0000043460313306_320373.0440.0RegionCalmodulin-binding
TgeneMAP6chr11:75526569chr11:75317049ENST0000043460313357_371373.0440.0RegionCalmodulin-binding
TgeneMAP6chr11:75623083chr11:75319367ENST0000030477104118_141301.6666666666667814.0RegionMn 1
TgeneMAP6chr11:75623083chr11:75319367ENST0000030477104126_140301.6666666666667814.0RegionCalmodulin-binding
TgeneMAP6chr11:75623083chr11:75319367ENST0000030477104153_176301.6666666666667814.0RegionMn 2
TgeneMAP6chr11:75623083chr11:75319367ENST0000030477104162_176301.6666666666667814.0RegionCalmodulin-binding
TgeneMAP6chr11:75623083chr11:75319367ENST0000030477104189_203301.6666666666667814.0RegionCalmodulin-binding
TgeneMAP6chr11:75623083chr11:75319367ENST0000030477104298_321301.6666666666667814.0RegionMn 3
TgeneMAP6chr11:75623083chr11:75319367ENST0000043460303118_141301.6666666666667440.0RegionMn 1
TgeneMAP6chr11:75623083chr11:75319367ENST0000043460303126_140301.6666666666667440.0RegionCalmodulin-binding
TgeneMAP6chr11:75623083chr11:75319367ENST0000043460303153_176301.6666666666667440.0RegionMn 2
TgeneMAP6chr11:75623083chr11:75319367ENST0000043460303162_176301.6666666666667440.0RegionCalmodulin-binding
TgeneMAP6chr11:75623083chr11:75319367ENST0000043460303189_203301.6666666666667440.0RegionCalmodulin-binding
TgeneMAP6chr11:75623083chr11:75319367ENST0000043460303298_321301.6666666666667440.0RegionMn 3
TgeneMAP6chr11:75672593chr11:75299229ENST0000030477124118_141438.6666666666667814.0RegionMn 1
TgeneMAP6chr11:75672593chr11:75299229ENST0000030477124126_140438.6666666666667814.0RegionCalmodulin-binding
TgeneMAP6chr11:75672593chr11:75299229ENST0000030477124153_176438.6666666666667814.0RegionMn 2
TgeneMAP6chr11:75672593chr11:75299229ENST0000030477124162_176438.6666666666667814.0RegionCalmodulin-binding
TgeneMAP6chr11:75672593chr11:75299229ENST0000030477124189_203438.6666666666667814.0RegionCalmodulin-binding
TgeneMAP6chr11:75672593chr11:75299229ENST0000030477124298_321438.6666666666667814.0RegionMn 3
TgeneMAP6chr11:75672593chr11:75299229ENST0000030477124306_320438.6666666666667814.0RegionCalmodulin-binding
TgeneMAP6chr11:75672593chr11:75299229ENST0000030477124357_371438.6666666666667814.0RegionCalmodulin-binding
TgeneMAP6chr11:75672593chr11:75299229ENST0000030477124384_398438.6666666666667814.0RegionCalmodulin-binding


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1077_UVRAG_75526569_MAP6_75317049_1077_UVRAG_75526569_MAP6_75317049_ranked_0.pdbUVRAG7567259375526569ENST00000526740MAP6chr1175317049-
MVGGGKGAAADAGRVPAPPLGGPWIEMSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQVEKPSVQSSKPKKTSASHKPTRKAK
DKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEAKESLAQPVSDSSKTQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSV
VPGPPKDLGPMIPLPVKDQDHTVPEPLKNESPVISAPVKDQGPSVPVPPKNQSPMVPAKVKDQGSVVPESLKDQGPRIPEPVKNQAPMVP
APVKDEGPMVSASVKDQGPMVSAPVKDQGPIVPAPVKGEGPIVPAPVKDEGPMVSAPIKDQDPMVPEHPKDESAMATAPIKNQGSMVSEP
VKNQGLVVSGPVKDQDVVVPEHAKVHDSAVVAPVKNQGPVVPESVKNQDPILPVLVKDQGPTVLQPPKNQGRIVPEPLKNQVPIVPVPLK
505


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
UVRAG_pLDDT.png
all structure
all structure
MAP6_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
UVRAG
MAP6


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to UVRAG-MAP6


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to UVRAG-MAP6


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource