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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:VEGFA-RSPH9

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: VEGFA-RSPH9
	FusionPDB ID: 98036
	FusionGDB2.0 ID: 98036
		Hgene	Tgene
	Gene symbol	VEGFA	RSPH9
	Gene ID	7422	221421
	Gene name	vascular endothelial growth factor A	radial spoke head component 9
	Synonyms	MVCD1\|VEGF\|VPF	C6orf206\|CILD12\|MRPS18AL1
	Cytomap	6p21.1	6p21.1
	Type of gene	protein-coding	protein-coding
	Description	vascular endothelial growth factor Avascular endothelial growth factor A121vascular endothelial growth factor A165vascular permeability factor	radial spoke head protein 9 homologradial spoke head 9 homolog
	Modification date	20200329	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000230480, ENST00000372055, ENST00000372064, ENST00000372067, ENST00000372077, ENST00000413642, ENST00000417285, ENST00000425836, ENST00000482630, ENST00000518689, ENST00000518824, ENST00000520948, ENST00000523125, ENST00000523873, ENST00000523950, ENST00000324450, ENST00000457104,	ENST00000372163, ENST00000372165,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 10 X 8=1040	6 X 5 X 4=120
	# samples	14	8
	** MAII score	log2(14/1040*10)=-2.89308479608349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: VEGFA [Title/Abstract] AND RSPH9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	VEGFA(43746655)-RSPH9(43638526), # samples:2
Anticipated loss of major functional domain due to fusion event.	VEGFA-RSPH9 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	VEGFA	GO:0000122	negative regulation of transcription by RNA polymerase II	18093989
Hgene	VEGFA	GO:0001525	angiogenesis	11427521\|21771332
Hgene	VEGFA	GO:0001666	response to hypoxia	16490744
Hgene	VEGFA	GO:0001934	positive regulation of protein phosphorylation	18386220\|19033661
Hgene	VEGFA	GO:0001938	positive regulation of endothelial cell proliferation	9202027\|10022831\|12714610\|16489009\|18386220\|18577655\|20497126
Hgene	VEGFA	GO:0002042	cell migration involved in sprouting angiogenesis	18059339\|20660291
Hgene	VEGFA	GO:0002092	positive regulation of receptor internalization	20660291
Hgene	VEGFA	GO:0008284	positive regulation of cell proliferation	7929439
Hgene	VEGFA	GO:0008360	regulation of cell shape	7929439\|10527820
Hgene	VEGFA	GO:0010595	positive regulation of endothelial cell migration	10022831\|19033661
Hgene	VEGFA	GO:0010628	positive regulation of gene expression	18386220
Hgene	VEGFA	GO:0010629	negative regulation of gene expression	28977001
Hgene	VEGFA	GO:0010749	regulation of nitric oxide mediated signal transduction	16150726
Hgene	VEGFA	GO:0030224	monocyte differentiation	21149635
Hgene	VEGFA	GO:0030225	macrophage differentiation	21149635
Hgene	VEGFA	GO:0030335	positive regulation of cell migration	7929439\|17470632
Hgene	VEGFA	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	1312256\|7929439
Hgene	VEGFA	GO:0031334	positive regulation of protein complex assembly	16489009\|19033661
Hgene	VEGFA	GO:0031954	positive regulation of protein autophosphorylation	20497126
Hgene	VEGFA	GO:0032147	activation of protein kinase activity	18059339\|20497126
Hgene	VEGFA	GO:0032793	positive regulation of CREB transcription factor activity	20497126
Hgene	VEGFA	GO:0033138	positive regulation of peptidyl-serine phosphorylation	18440775\|20497126
Hgene	VEGFA	GO:0035148	tube formation	19033661
Hgene	VEGFA	GO:0035767	endothelial cell chemotaxis	18440775
Hgene	VEGFA	GO:0035924	cellular response to vascular endothelial growth factor stimulus	18440775\|20497126
Hgene	VEGFA	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	18440775\|20497126\|21245381
Hgene	VEGFA	GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	17470632
Hgene	VEGFA	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	19390056
Hgene	VEGFA	GO:0043117	positive regulation of vascular permeability	26598555
Hgene	VEGFA	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	18386220
Hgene	VEGFA	GO:0043406	positive regulation of MAP kinase activity	18440775
Hgene	VEGFA	GO:0043536	positive regulation of blood vessel endothelial cell migration	9202027\|18440775\|20497126
Hgene	VEGFA	GO:0045766	positive regulation of angiogenesis	18440775\|18577655\|19033661\|20497126
Hgene	VEGFA	GO:0045785	positive regulation of cell adhesion	19674970
Hgene	VEGFA	GO:0045944	positive regulation of transcription by RNA polymerase II	18059339
Hgene	VEGFA	GO:0048010	vascular endothelial growth factor receptor signaling pathway	21245381
Hgene	VEGFA	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	10022831\|16489009\|20048167\|21245381\|26598555
Hgene	VEGFA	GO:0050918	positive chemotaxis	20497126
Hgene	VEGFA	GO:0050927	positive regulation of positive chemotaxis	7929439\|12744932
Hgene	VEGFA	GO:0051272	positive regulation of cellular component movement	10527820\|12744932
Hgene	VEGFA	GO:0051894	positive regulation of focal adhesion assembly	16489009
Hgene	VEGFA	GO:0071456	cellular response to hypoxia	10575000
Hgene	VEGFA	GO:0090037	positive regulation of protein kinase C signaling	18059339
Hgene	VEGFA	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	20551324
Hgene	VEGFA	GO:0097533	cellular stress response to acid chemical	26299712
Hgene	VEGFA	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	20660291
Hgene	VEGFA	GO:1900745	positive regulation of p38MAPK cascade	18386220
Hgene	VEGFA	GO:1901727	positive regulation of histone deacetylase activity	20497126
Hgene	VEGFA	GO:1903141	negative regulation of establishment of endothelial barrier	20048167
Hgene	VEGFA	GO:1903392	negative regulation of adherens junction organization	26598555
Hgene	VEGFA	GO:1903572	positive regulation of protein kinase D signaling	20497126
Hgene	VEGFA	GO:1903672	positive regulation of sprouting angiogenesis	26299712
Hgene	VEGFA	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin	26598555

Fusion gene breakpoints across VEGFA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RSPH9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	CESC	TCGA-DS-A3LQ-01A	VEGFA	chr6	43746654	+	RSPH9	chr6	43638525	+
ChimerDB4	CESC	TCGA-DS-A3LQ-01A	VEGFA	chr6	43746655	-	RSPH9	chr6	43638526	+
ChimerDB4	CESC	TCGA-DS-A3LQ-01A	VEGFA	chr6	43746655	+	RSPH9	chr6	43638526	+
ChimerDB4	CESC	TCGA-DS-A3LQ	VEGFA	chr6	43746655	+	RSPH9	chr6	43638525	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000372067	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638525	+	3267	1456	494	1654	386
ENST00000417285	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638525	+	2773	962	0	1160	386
ENST00000413642	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638525	+	2773	962	0	1160	386
ENST00000372055	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638525	+	2773	962	0	1160	386
ENST00000482630	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638525	+	2773	962	0	1160	386
ENST00000425836	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638525	+	2773	962	0	1160	386
ENST00000372064	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638525	+	2773	962	0	1160	386
ENST00000372077	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638525	+	2698	887	78	1085	335
ENST00000520948	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638525	+	2397	586	38	784	248
ENST00000523873	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638525	+	2271	460	38	658	206
ENST00000523950	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638525	+	2271	460	38	658	206
ENST00000518689	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638525	+	2233	422	0	620	206
ENST00000523125	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638525	+	2233	422	0	620	206
ENST00000518824	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638525	+	2233	422	0	620	206
ENST00000230480	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638525	+	2277	466	128	664	178
ENST00000372067	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638526	+	3267	1456	494	1654	386
ENST00000417285	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638526	+	2773	962	0	1160	386
ENST00000413642	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638526	+	2773	962	0	1160	386
ENST00000372055	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638526	+	2773	962	0	1160	386
ENST00000482630	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638526	+	2773	962	0	1160	386
ENST00000425836	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638526	+	2773	962	0	1160	386
ENST00000372064	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638526	+	2773	962	0	1160	386
ENST00000372077	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638526	+	2698	887	78	1085	335
ENST00000520948	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638526	+	2397	586	38	784	248
ENST00000523873	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638526	+	2271	460	38	658	206
ENST00000523950	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638526	+	2271	460	38	658	206
ENST00000518689	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638526	+	2233	422	0	620	206
ENST00000523125	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638526	+	2233	422	0	620	206
ENST00000518824	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638526	+	2233	422	0	620	206
ENST00000230480	VEGFA	chr6	43746655	+	ENST00000372165	RSPH9	chr6	43638526	+	2277	466	128	664	178
ENST00000372067	VEGFA	chr6	43746654	+	ENST00000372165	RSPH9	chr6	43638525	+	3267	1456	494	1654	386
ENST00000417285	VEGFA	chr6	43746654	+	ENST00000372165	RSPH9	chr6	43638525	+	2773	962	0	1160	386
ENST00000413642	VEGFA	chr6	43746654	+	ENST00000372165	RSPH9	chr6	43638525	+	2773	962	0	1160	386
ENST00000372055	VEGFA	chr6	43746654	+	ENST00000372165	RSPH9	chr6	43638525	+	2773	962	0	1160	386
ENST00000482630	VEGFA	chr6	43746654	+	ENST00000372165	RSPH9	chr6	43638525	+	2773	962	0	1160	386
ENST00000425836	VEGFA	chr6	43746654	+	ENST00000372165	RSPH9	chr6	43638525	+	2773	962	0	1160	386
ENST00000372064	VEGFA	chr6	43746654	+	ENST00000372165	RSPH9	chr6	43638525	+	2773	962	0	1160	386
ENST00000372077	VEGFA	chr6	43746654	+	ENST00000372165	RSPH9	chr6	43638525	+	2698	887	78	1085	335
ENST00000520948	VEGFA	chr6	43746654	+	ENST00000372165	RSPH9	chr6	43638525	+	2397	586	38	784	248
ENST00000523873	VEGFA	chr6	43746654	+	ENST00000372165	RSPH9	chr6	43638525	+	2271	460	38	658	206
ENST00000523950	VEGFA	chr6	43746654	+	ENST00000372165	RSPH9	chr6	43638525	+	2271	460	38	658	206
ENST00000518689	VEGFA	chr6	43746654	+	ENST00000372165	RSPH9	chr6	43638525	+	2233	422	0	620	206
ENST00000523125	VEGFA	chr6	43746654	+	ENST00000372165	RSPH9	chr6	43638525	+	2233	422	0	620	206
ENST00000518824	VEGFA	chr6	43746654	+	ENST00000372165	RSPH9	chr6	43638525	+	2233	422	0	620	206
ENST00000230480	VEGFA	chr6	43746654	+	ENST00000372165	RSPH9	chr6	43638525	+	2277	466	128	664	178

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000372067	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638525	+	0.19361189	0.80638814
ENST00000417285	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638525	+	0.1424665	0.8575335
ENST00000413642	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638525	+	0.1424665	0.8575335
ENST00000372055	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638525	+	0.1424665	0.8575335
ENST00000482630	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638525	+	0.1424665	0.8575335
ENST00000425836	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638525	+	0.1424665	0.8575335
ENST00000372064	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638525	+	0.1424665	0.8575335
ENST00000372077	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638525	+	0.14898354	0.85101646
ENST00000520948	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638525	+	0.16571102	0.83428895
ENST00000523873	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638525	+	0.15937775	0.84062225
ENST00000523950	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638525	+	0.15937775	0.84062225
ENST00000518689	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638525	+	0.16749682	0.83250314
ENST00000523125	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638525	+	0.16749682	0.83250314
ENST00000518824	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638525	+	0.16749682	0.83250314
ENST00000230480	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638525	+	0.15487221	0.84512776
ENST00000372067	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638526	+	0.19361189	0.80638814
ENST00000417285	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638526	+	0.1424665	0.8575335
ENST00000413642	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638526	+	0.1424665	0.8575335
ENST00000372055	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638526	+	0.1424665	0.8575335
ENST00000482630	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638526	+	0.1424665	0.8575335
ENST00000425836	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638526	+	0.1424665	0.8575335
ENST00000372064	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638526	+	0.1424665	0.8575335
ENST00000372077	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638526	+	0.14898354	0.85101646
ENST00000520948	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638526	+	0.16571102	0.83428895
ENST00000523873	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638526	+	0.15937775	0.84062225
ENST00000523950	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638526	+	0.15937775	0.84062225
ENST00000518689	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638526	+	0.16749682	0.83250314
ENST00000523125	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638526	+	0.16749682	0.83250314
ENST00000518824	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638526	+	0.16749682	0.83250314
ENST00000230480	ENST00000372165	VEGFA	chr6	43746655	+	RSPH9	chr6	43638526	+	0.15487221	0.84512776
ENST00000372067	ENST00000372165	VEGFA	chr6	43746654	+	RSPH9	chr6	43638525	+	0.19361189	0.80638814
ENST00000417285	ENST00000372165	VEGFA	chr6	43746654	+	RSPH9	chr6	43638525	+	0.1424665	0.8575335
ENST00000413642	ENST00000372165	VEGFA	chr6	43746654	+	RSPH9	chr6	43638525	+	0.1424665	0.8575335
ENST00000372055	ENST00000372165	VEGFA	chr6	43746654	+	RSPH9	chr6	43638525	+	0.1424665	0.8575335
ENST00000482630	ENST00000372165	VEGFA	chr6	43746654	+	RSPH9	chr6	43638525	+	0.1424665	0.8575335
ENST00000425836	ENST00000372165	VEGFA	chr6	43746654	+	RSPH9	chr6	43638525	+	0.1424665	0.8575335
ENST00000372064	ENST00000372165	VEGFA	chr6	43746654	+	RSPH9	chr6	43638525	+	0.1424665	0.8575335
ENST00000372077	ENST00000372165	VEGFA	chr6	43746654	+	RSPH9	chr6	43638525	+	0.14898354	0.85101646
ENST00000520948	ENST00000372165	VEGFA	chr6	43746654	+	RSPH9	chr6	43638525	+	0.16571102	0.83428895
ENST00000523873	ENST00000372165	VEGFA	chr6	43746654	+	RSPH9	chr6	43638525	+	0.15937775	0.84062225
ENST00000523950	ENST00000372165	VEGFA	chr6	43746654	+	RSPH9	chr6	43638525	+	0.15937775	0.84062225
ENST00000518689	ENST00000372165	VEGFA	chr6	43746654	+	RSPH9	chr6	43638525	+	0.16749682	0.83250314
ENST00000523125	ENST00000372165	VEGFA	chr6	43746654	+	RSPH9	chr6	43638525	+	0.16749682	0.83250314
ENST00000518824	ENST00000372165	VEGFA	chr6	43746654	+	RSPH9	chr6	43638525	+	0.16749682	0.83250314
ENST00000230480	ENST00000372165	VEGFA	chr6	43746654	+	RSPH9	chr6	43638525	+	0.15487221	0.84512776

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>98036_98036_1_VEGFA-RSPH9_VEGFA_chr6_43746654_ENST00000230480_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=178AA_BP=113
MAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIG

--------------------------------------------------------------

>98036_98036_2_VEGFA-RSPH9_VEGFA_chr6_43746654_ENST00000372055_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=386AA_BP=321
LTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_3_VEGFA-RSPH9_VEGFA_chr6_43746654_ENST00000372064_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=386AA_BP=321
LTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_4_VEGFA-RSPH9_VEGFA_chr6_43746654_ENST00000372067_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=386AA_BP=321
MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_5_VEGFA-RSPH9_VEGFA_chr6_43746654_ENST00000372077_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=335AA_BP=270
MKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALAR
ASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSY
CHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEK

--------------------------------------------------------------

>98036_98036_6_VEGFA-RSPH9_VEGFA_chr6_43746654_ENST00000413642_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=386AA_BP=321
LTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_7_VEGFA-RSPH9_VEGFA_chr6_43746654_ENST00000417285_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=386AA_BP=321
LTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_8_VEGFA-RSPH9_VEGFA_chr6_43746654_ENST00000425836_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=386AA_BP=321
LTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_9_VEGFA-RSPH9_VEGFA_chr6_43746654_ENST00000482630_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=386AA_BP=321
LTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_10_VEGFA-RSPH9_VEGFA_chr6_43746654_ENST00000518689_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=206AA_BP=141
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_11_VEGFA-RSPH9_VEGFA_chr6_43746654_ENST00000518824_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=206AA_BP=141
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_12_VEGFA-RSPH9_VEGFA_chr6_43746654_ENST00000520948_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=248AA_BP=183
MARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQ
RSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRAR

--------------------------------------------------------------

>98036_98036_13_VEGFA-RSPH9_VEGFA_chr6_43746654_ENST00000523125_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=206AA_BP=141
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_14_VEGFA-RSPH9_VEGFA_chr6_43746654_ENST00000523873_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=206AA_BP=141
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_15_VEGFA-RSPH9_VEGFA_chr6_43746654_ENST00000523950_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=206AA_BP=141
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_16_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000230480_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=178AA_BP=113
MAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIG

--------------------------------------------------------------

>98036_98036_17_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000230480_RSPH9_chr6_43638526_ENST00000372165_length(amino acids)=178AA_BP=113
MAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIG

--------------------------------------------------------------

>98036_98036_18_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000372055_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=386AA_BP=321
LTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_19_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000372055_RSPH9_chr6_43638526_ENST00000372165_length(amino acids)=386AA_BP=321
LTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_20_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000372064_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=386AA_BP=321
LTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_21_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000372064_RSPH9_chr6_43638526_ENST00000372165_length(amino acids)=386AA_BP=321
LTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_22_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000372067_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=386AA_BP=321
MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_23_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000372067_RSPH9_chr6_43638526_ENST00000372165_length(amino acids)=386AA_BP=321
MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_24_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000372077_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=335AA_BP=270
MKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALAR
ASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSY
CHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEK

--------------------------------------------------------------

>98036_98036_25_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000372077_RSPH9_chr6_43638526_ENST00000372165_length(amino acids)=335AA_BP=270
MKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALAR
ASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSY
CHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEK

--------------------------------------------------------------

>98036_98036_26_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000413642_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=386AA_BP=321
LTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_27_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000413642_RSPH9_chr6_43638526_ENST00000372165_length(amino acids)=386AA_BP=321
LTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_28_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000417285_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=386AA_BP=321
LTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_29_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000417285_RSPH9_chr6_43638526_ENST00000372165_length(amino acids)=386AA_BP=321
LTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_30_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000425836_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=386AA_BP=321
LTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_31_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000425836_RSPH9_chr6_43638526_ENST00000372165_length(amino acids)=386AA_BP=321
LTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_32_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000482630_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=386AA_BP=321
LTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_33_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000482630_RSPH9_chr6_43638526_ENST00000372165_length(amino acids)=386AA_BP=321
LTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEP
QPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASET
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_34_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000518689_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=206AA_BP=141
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_35_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000518689_RSPH9_chr6_43638526_ENST00000372165_length(amino acids)=206AA_BP=141
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_36_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000518824_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=206AA_BP=141
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_37_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000518824_RSPH9_chr6_43638526_ENST00000372165_length(amino acids)=206AA_BP=141
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_38_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000520948_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=248AA_BP=183
MARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQ
RSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRAR

--------------------------------------------------------------

>98036_98036_39_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000520948_RSPH9_chr6_43638526_ENST00000372165_length(amino acids)=248AA_BP=183
MARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQ
RSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRAR

--------------------------------------------------------------

>98036_98036_40_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000523125_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=206AA_BP=141
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_41_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000523125_RSPH9_chr6_43638526_ENST00000372165_length(amino acids)=206AA_BP=141
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_42_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000523873_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=206AA_BP=141
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_43_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000523873_RSPH9_chr6_43638526_ENST00000372165_length(amino acids)=206AA_BP=141
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_44_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000523950_RSPH9_chr6_43638525_ENST00000372165_length(amino acids)=206AA_BP=141
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

>98036_98036_45_VEGFA-RSPH9_VEGFA_chr6_43746655_ENST00000523950_RSPH9_chr6_43638526_ENST00000372165_length(amino acids)=206AA_BP=141
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDE
GLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKVLEHPDGEGQCPGGAAQPALAGPHLLPCSPHQELWLRLR

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:43746655/chr6:43638526)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
VEGFA
RSPH9

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to VEGFA-RSPH9

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to VEGFA-RSPH9

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source