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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:VMP1-BRCA1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: VMP1-BRCA1
	FusionPDB ID: 98195
	FusionGDB2.0 ID: 98195
		Hgene	Tgene
	Gene symbol	VMP1	BRCA1
	Gene ID	81671	672
	Gene name	vacuole membrane protein 1	BRCA1 DNA repair associated
	Synonyms	EPG3\|TANGO5\|TMEM49	BRCAI\|BRCC1\|BROVCA1\|FANCS\|IRIS\|PNCA4\|PPP1R53\|PSCP\|RNF53
	Cytomap	17q23.1	17q21.31
	Type of gene	protein-coding	protein-coding
	Description	vacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homolog	breast cancer type 1 susceptibility proteinBRCA1/BRCA2-containing complex, subunit 1Fanconi anemia, complementation group SRING finger protein 53breast and ovarian cancer susceptibility protein 1breast cancer 1, early onsetearly onset breast cancer
	Modification date	20200327	20200329
	UniProtAcc	.	UIMC1
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000262291, ENST00000536180, ENST00000537567, ENST00000539763, ENST00000545362, ENST00000588617,	ENST00000471181, ENST00000491747, ENST00000493795, ENST00000586385, ENST00000591534, ENST00000591849, ENST00000309486, ENST00000346315, ENST00000351666, ENST00000352993, ENST00000354071, ENST00000357654, ENST00000468300,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	34 X 17 X 12=6936	7 X 6 X 6=252
	# samples	38	7
	** MAII score	log2(38/6936*10)=-4.19003257489089 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: VMP1 [Title/Abstract] AND BRCA1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	VMP1(57851246)-BRCA1(41234592), # samples:2
Anticipated loss of major functional domain due to fusion event.	VMP1-BRCA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. VMP1-BRCA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. VMP1-BRCA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. VMP1-BRCA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	BRCA1	GO:0000724	double-strand break repair via homologous recombination	17349954
Tgene	BRCA1	GO:0006301	postreplication repair	17349954
Tgene	BRCA1	GO:0006302	double-strand break repair	22186889
Tgene	BRCA1	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	14654789
Tgene	BRCA1	GO:0016567	protein ubiquitination	17349954
Tgene	BRCA1	GO:0031398	positive regulation of protein ubiquitination	15965487
Tgene	BRCA1	GO:0035066	positive regulation of histone acetylation	20820192
Tgene	BRCA1	GO:0043627	response to estrogen	8895509
Tgene	BRCA1	GO:0045892	negative regulation of transcription, DNA-templated	16288014
Tgene	BRCA1	GO:0045893	positive regulation of transcription, DNA-templated	20160719
Tgene	BRCA1	GO:0045944	positive regulation of transcription by RNA polymerase II	16331276
Tgene	BRCA1	GO:0051571	positive regulation of histone H3-K4 methylation	20820192
Tgene	BRCA1	GO:0051573	negative regulation of histone H3-K9 methylation	20820192
Tgene	BRCA1	GO:0051865	protein autoubiquitination	12890688\|20351172
Tgene	BRCA1	GO:0070512	positive regulation of histone H4-K20 methylation	20820192
Tgene	BRCA1	GO:0071158	positive regulation of cell cycle arrest	21102443
Tgene	BRCA1	GO:0071681	cellular response to indole-3-methanol	10868478
Tgene	BRCA1	GO:0085020	protein K6-linked ubiquitination	12890688\|20351172
Tgene	BRCA1	GO:2000617	positive regulation of histone H3-K9 acetylation	20820192
Tgene	BRCA1	GO:2000620	positive regulation of histone H4-K16 acetylation	20820192

Fusion gene breakpoints across VMP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BRCA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-KF-A41W-01A	VMP1	chr17	57851246	-	BRCA1	chr17	41234592	-
ChimerDB4	SARC	TCGA-KF-A41W-01A	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000262291	VMP1	chr17	57851246	+	ENST00000357654	BRCA1	chr17	41234592	-	3814	1024	253	2430	725
ENST00000262291	VMP1	chr17	57851246	+	ENST00000351666	BRCA1	chr17	41234592	-	3813	1024	253	2430	725
ENST00000262291	VMP1	chr17	57851246	+	ENST00000309486	BRCA1	chr17	41234592	-	3813	1024	253	2430	725
ENST00000262291	VMP1	chr17	57851246	+	ENST00000346315	BRCA1	chr17	41234592	-	3096	1024	253	1713	486
ENST00000262291	VMP1	chr17	57851246	+	ENST00000354071	BRCA1	chr17	41234592	-	3018	1024	253	1635	460
ENST00000262291	VMP1	chr17	57851246	+	ENST00000352993	BRCA1	chr17	41234592	-	3813	1024	253	2430	725
ENST00000262291	VMP1	chr17	57851246	+	ENST00000468300	BRCA1	chr17	41234592	-	3227	1024	253	2247	664
ENST00000537567	VMP1	chr17	57851246	+	ENST00000357654	BRCA1	chr17	41234592	-	3429	639	327	2045	572
ENST00000537567	VMP1	chr17	57851246	+	ENST00000351666	BRCA1	chr17	41234592	-	3428	639	327	2045	572
ENST00000537567	VMP1	chr17	57851246	+	ENST00000309486	BRCA1	chr17	41234592	-	3428	639	327	2045	572
ENST00000537567	VMP1	chr17	57851246	+	ENST00000346315	BRCA1	chr17	41234592	-	2711	639	327	1328	333
ENST00000537567	VMP1	chr17	57851246	+	ENST00000354071	BRCA1	chr17	41234592	-	2633	639	327	1250	307
ENST00000537567	VMP1	chr17	57851246	+	ENST00000352993	BRCA1	chr17	41234592	-	3428	639	327	2045	572
ENST00000537567	VMP1	chr17	57851246	+	ENST00000468300	BRCA1	chr17	41234592	-	2842	639	327	1862	511
ENST00000539763	VMP1	chr17	57851246	+	ENST00000357654	BRCA1	chr17	41234592	-	3493	703	238	2109	623
ENST00000539763	VMP1	chr17	57851246	+	ENST00000351666	BRCA1	chr17	41234592	-	3492	703	238	2109	623
ENST00000539763	VMP1	chr17	57851246	+	ENST00000309486	BRCA1	chr17	41234592	-	3492	703	238	2109	623
ENST00000539763	VMP1	chr17	57851246	+	ENST00000346315	BRCA1	chr17	41234592	-	2775	703	238	1392	384
ENST00000539763	VMP1	chr17	57851246	+	ENST00000354071	BRCA1	chr17	41234592	-	2697	703	238	1314	358
ENST00000539763	VMP1	chr17	57851246	+	ENST00000352993	BRCA1	chr17	41234592	-	3492	703	238	2109	623
ENST00000539763	VMP1	chr17	57851246	+	ENST00000468300	BRCA1	chr17	41234592	-	2906	703	238	1926	562
ENST00000536180	VMP1	chr17	57851246	+	ENST00000357654	BRCA1	chr17	41234592	-	3523	733	310	2139	609
ENST00000536180	VMP1	chr17	57851246	+	ENST00000351666	BRCA1	chr17	41234592	-	3522	733	310	2139	609
ENST00000536180	VMP1	chr17	57851246	+	ENST00000309486	BRCA1	chr17	41234592	-	3522	733	310	2139	609
ENST00000536180	VMP1	chr17	57851246	+	ENST00000346315	BRCA1	chr17	41234592	-	2805	733	310	1422	370
ENST00000536180	VMP1	chr17	57851246	+	ENST00000354071	BRCA1	chr17	41234592	-	2727	733	310	1344	344
ENST00000536180	VMP1	chr17	57851246	+	ENST00000352993	BRCA1	chr17	41234592	-	3522	733	310	2139	609
ENST00000536180	VMP1	chr17	57851246	+	ENST00000468300	BRCA1	chr17	41234592	-	2936	733	310	1956	548
ENST00000545362	VMP1	chr17	57851246	+	ENST00000357654	BRCA1	chr17	41234592	-	3389	599	41	2005	654
ENST00000545362	VMP1	chr17	57851246	+	ENST00000351666	BRCA1	chr17	41234592	-	3388	599	41	2005	654
ENST00000545362	VMP1	chr17	57851246	+	ENST00000309486	BRCA1	chr17	41234592	-	3388	599	41	2005	654
ENST00000545362	VMP1	chr17	57851246	+	ENST00000346315	BRCA1	chr17	41234592	-	2671	599	41	1288	415
ENST00000545362	VMP1	chr17	57851246	+	ENST00000354071	BRCA1	chr17	41234592	-	2593	599	41	1210	389
ENST00000545362	VMP1	chr17	57851246	+	ENST00000352993	BRCA1	chr17	41234592	-	3388	599	41	2005	654
ENST00000545362	VMP1	chr17	57851246	+	ENST00000468300	BRCA1	chr17	41234592	-	2802	599	41	1822	593

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000262291	ENST00000357654	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.000997482	0.9990025
ENST00000262291	ENST00000351666	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.00099385	0.9990062
ENST00000262291	ENST00000309486	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.00099385	0.9990062
ENST00000262291	ENST00000346315	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.001053168	0.99894685
ENST00000262291	ENST00000354071	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.000910196	0.99908984
ENST00000262291	ENST00000352993	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.00099385	0.9990062
ENST00000262291	ENST00000468300	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.001806842	0.9981932
ENST00000537567	ENST00000357654	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.000676894	0.9993231
ENST00000537567	ENST00000351666	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.00067458	0.9993254
ENST00000537567	ENST00000309486	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.00067458	0.9993254
ENST00000537567	ENST00000346315	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.001575971	0.99842405
ENST00000537567	ENST00000354071	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.001444761	0.99855524
ENST00000537567	ENST00000352993	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.00067458	0.9993254
ENST00000537567	ENST00000468300	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.001207338	0.99879265
ENST00000539763	ENST00000357654	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.000566277	0.9994337
ENST00000539763	ENST00000351666	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.000565464	0.99943453
ENST00000539763	ENST00000309486	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.000565464	0.99943453
ENST00000539763	ENST00000346315	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.001041425	0.9989586
ENST00000539763	ENST00000354071	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.002556994	0.99744296
ENST00000539763	ENST00000352993	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.000565464	0.99943453
ENST00000539763	ENST00000468300	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.001576579	0.99842346
ENST00000536180	ENST00000357654	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.00090823	0.99909174
ENST00000536180	ENST00000351666	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.000905252	0.9990947
ENST00000536180	ENST00000309486	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.000905252	0.9990947
ENST00000536180	ENST00000346315	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.001070908	0.9989291
ENST00000536180	ENST00000354071	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.001163163	0.9988368
ENST00000536180	ENST00000352993	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.000905252	0.9990947
ENST00000536180	ENST00000468300	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.001490974	0.998509
ENST00000545362	ENST00000357654	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.000594136	0.99940586
ENST00000545362	ENST00000351666	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.000591741	0.99940825
ENST00000545362	ENST00000309486	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.000591741	0.99940825
ENST00000545362	ENST00000346315	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.001012047	0.998988
ENST00000545362	ENST00000354071	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.001035183	0.9989648
ENST00000545362	ENST00000352993	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.000591741	0.99940825
ENST00000545362	ENST00000468300	VMP1	chr17	57851246	+	BRCA1	chr17	41234592	-	0.001548533	0.9984515

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>98195_98195_1_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000262291_BRCA1_chr17_41234592_ENST00000309486_length(amino acids)=725AA_BP=257
MRSGAAGVGAAPQELLIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSK
LWHRQSIVVSFLLLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPP
YPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQ
QEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSP
SKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESA
RVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTN
LITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICC
YGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQI

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>98195_98195_2_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000262291_BRCA1_chr17_41234592_ENST00000346315_length(amino acids)=486AA_BP=257
MRSGAAGVGAAPQELLIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSK
LWHRQSIVVSFLLLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPP
YPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQ
QEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVR
GDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQM

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>98195_98195_3_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000262291_BRCA1_chr17_41234592_ENST00000351666_length(amino acids)=725AA_BP=257
MRSGAAGVGAAPQELLIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSK
LWHRQSIVVSFLLLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPP
YPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQ
QEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSP
SKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESA
RVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTN
LITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICC
YGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQI

--------------------------------------------------------------

>98195_98195_4_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000262291_BRCA1_chr17_41234592_ENST00000352993_length(amino acids)=725AA_BP=257
MRSGAAGVGAAPQELLIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSK
LWHRQSIVVSFLLLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPP
YPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQ
QEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSP
SKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESA
RVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTN
LITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICC
YGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQI

--------------------------------------------------------------

>98195_98195_5_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000262291_BRCA1_chr17_41234592_ENST00000354071_length(amino acids)=460AA_BP=257
MRSGAAGVGAAPQELLIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSK
LWHRQSIVVSFLLLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPP
YPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQ
QEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKGVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRG
LEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTY

--------------------------------------------------------------

>98195_98195_6_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000262291_BRCA1_chr17_41234592_ENST00000357654_length(amino acids)=725AA_BP=257
MRSGAAGVGAAPQELLIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSK
LWHRQSIVVSFLLLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPP
YPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQ
QEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSP
SKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESA
RVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTN
LITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICC
YGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQI

--------------------------------------------------------------

>98195_98195_7_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000262291_BRCA1_chr17_41234592_ENST00000468300_length(amino acids)=664AA_BP=257
MRSGAAGVGAAPQELLIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSK
LWHRQSIVVSFLLLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPP
YPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQ
QEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPS
KCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESAR
VGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNL
ITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCY

--------------------------------------------------------------

>98195_98195_8_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000536180_BRCA1_chr17_41234592_ENST00000309486_length(amino acids)=609AA_BP=141
MDLKYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKV
RIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIIS
DSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPS
QEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSP
AAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYF
LGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKE

--------------------------------------------------------------

>98195_98195_9_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000536180_BRCA1_chr17_41234592_ENST00000346315_length(amino acids)=370AA_BP=141
MDLKYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKV
RIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIIS
DSSALEDLRNPEQSTSEKDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRG
LEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTY

--------------------------------------------------------------

>98195_98195_10_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000536180_BRCA1_chr17_41234592_ENST00000351666_length(amino acids)=609AA_BP=141
MDLKYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKV
RIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIIS
DSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPS
QEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSP
AAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYF
LGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKE

--------------------------------------------------------------

>98195_98195_11_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000536180_BRCA1_chr17_41234592_ENST00000352993_length(amino acids)=609AA_BP=141
MDLKYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKV
RIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIIS
DSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPS
QEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSP
AAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYF
LGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKE

--------------------------------------------------------------

>98195_98195_12_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000536180_BRCA1_chr17_41234592_ENST00000354071_length(amino acids)=344AA_BP=141
MDLKYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKV
RIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIIS
DSSALEDLRNPEQSTSEKGVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGA

--------------------------------------------------------------

>98195_98195_13_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000536180_BRCA1_chr17_41234592_ENST00000357654_length(amino acids)=609AA_BP=141
MDLKYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKV
RIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIIS
DSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPS
QEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSP
AAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYF
LGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKE

--------------------------------------------------------------

>98195_98195_14_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000536180_BRCA1_chr17_41234592_ENST00000468300_length(amino acids)=548AA_BP=141
MDLKYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKV
RIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIIS
DSSALEDLRNPEQSTSEKVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQ
EELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPA
AAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFL
GIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTGCPPNCGCAARCLDRGQW

--------------------------------------------------------------

>98195_98195_15_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000537567_BRCA1_chr17_41234592_ENST00000309486_length(amino acids)=572AA_BP=104
MDLKGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEY
QEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEG
LSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGT
PYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMS
MVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVV
NGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAP

--------------------------------------------------------------

>98195_98195_16_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000537567_BRCA1_chr17_41234592_ENST00000346315_length(amino acids)=333AA_BP=104
MDLKGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEY
QEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKDAEFVCERTLKYFLGIAGG
KWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTL

--------------------------------------------------------------

>98195_98195_17_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000537567_BRCA1_chr17_41234592_ENST00000351666_length(amino acids)=572AA_BP=104
MDLKGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEY
QEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEG
LSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGT
PYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMS
MVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVV
NGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAP

--------------------------------------------------------------

>98195_98195_18_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000537567_BRCA1_chr17_41234592_ENST00000352993_length(amino acids)=572AA_BP=104
MDLKGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEY
QEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEG
LSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGT
PYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMS
MVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVV
NGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAP

--------------------------------------------------------------

>98195_98195_19_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000537567_BRCA1_chr17_41234592_ENST00000354071_length(amino acids)=307AA_BP=104
MDLKGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEY
QEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKGVTQSIKERKMLNEHDFEV
RGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQ

--------------------------------------------------------------

>98195_98195_20_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000537567_BRCA1_chr17_41234592_ENST00000357654_length(amino acids)=572AA_BP=104
MDLKGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEY
QEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEG
LSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGT
PYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMS
MVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVV
NGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAP

--------------------------------------------------------------

>98195_98195_21_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000537567_BRCA1_chr17_41234592_ENST00000468300_length(amino acids)=511AA_BP=104
MDLKGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEY
QEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKVLTSQKSSEYPISQNPEGL
SADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTP
YLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSM
VVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVN

--------------------------------------------------------------

>98195_98195_22_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000539763_BRCA1_chr17_41234592_ENST00000309486_length(amino acids)=623AA_BP=155
MLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEG
TEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQ
HGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYM
HSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSAL
KVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMK
TDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQL

--------------------------------------------------------------

>98195_98195_23_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000539763_BRCA1_chr17_41234592_ENST00000346315_length(amino acids)=384AA_BP=155
MLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEG
TEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQ
HGSQPSNSYPSIISDSSALEDLRNPEQSTSEKDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGP
KRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVL

--------------------------------------------------------------

>98195_98195_24_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000539763_BRCA1_chr17_41234592_ENST00000351666_length(amino acids)=623AA_BP=155
MLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEG
TEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQ
HGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYM
HSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSAL
KVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMK
TDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQL

--------------------------------------------------------------

>98195_98195_25_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000539763_BRCA1_chr17_41234592_ENST00000352993_length(amino acids)=623AA_BP=155
MLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEG
TEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQ
HGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYM
HSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSAL
KVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMK
TDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQL

--------------------------------------------------------------

>98195_98195_26_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000539763_BRCA1_chr17_41234592_ENST00000354071_length(amino acids)=358AA_BP=155
MLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEG
TEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQ
HGSQPSNSYPSIISDSSALEDLRNPEQSTSEKGVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNM

--------------------------------------------------------------

>98195_98195_27_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000539763_BRCA1_chr17_41234592_ENST00000357654_length(amino acids)=623AA_BP=155
MLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEG
TEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQ
HGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYM
HSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSAL
KVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMK
TDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQL

--------------------------------------------------------------

>98195_98195_28_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000539763_BRCA1_chr17_41234592_ENST00000468300_length(amino acids)=562AA_BP=155
MLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEG
TEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQQRDTMQHNLIKLQQEMAELEAVLEQ
HGSQPSNSYPSIISDSSALEDLRNPEQSTSEKVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMH
SCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALK
VPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKT
DAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTGCPP

--------------------------------------------------------------

>98195_98195_29_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000545362_BRCA1_chr17_41234592_ENST00000309486_length(amino acids)=654AA_BP=186
MIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLL
AVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLE
HAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEV
SADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGIS
LFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTP
EEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGP
KRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVL

--------------------------------------------------------------

>98195_98195_30_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000545362_BRCA1_chr17_41234592_ENST00000346315_length(amino acids)=415AA_BP=186
MIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLL
AVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLE
HAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKDAEFVCERTLKYFLGIAGGKWVVSYFW
VTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIV

--------------------------------------------------------------

>98195_98195_31_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000545362_BRCA1_chr17_41234592_ENST00000351666_length(amino acids)=654AA_BP=186
MIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLL
AVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLE
HAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEV
SADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGIS
LFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTP
EEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGP
KRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVL

--------------------------------------------------------------

>98195_98195_32_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000545362_BRCA1_chr17_41234592_ENST00000352993_length(amino acids)=654AA_BP=186
MIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLL
AVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLE
HAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEV
SADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGIS
LFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTP
EEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGP
KRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVL

--------------------------------------------------------------

>98195_98195_33_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000545362_BRCA1_chr17_41234592_ENST00000354071_length(amino acids)=389AA_BP=186
MIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLL
AVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLE
HAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKGVTQSIKERKMLNEHDFEVRGDVVNGR
NHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVT

--------------------------------------------------------------

>98195_98195_34_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000545362_BRCA1_chr17_41234592_ENST00000357654_length(amino acids)=654AA_BP=186
MIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLL
AVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLE
HAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEV
SADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGIS
LFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTP
EEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGP
KRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVL

--------------------------------------------------------------

>98195_98195_35_VMP1-BRCA1_VMP1_chr17_57851246_ENST00000545362_BRCA1_chr17_41234592_ENST00000468300_length(amino acids)=593AA_BP=186
MIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLL
AVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLE
HAESAQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKVLTSQKSSEYPISQNPEGLSADKFEVS
ADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISL
FSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPE
EFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPK

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:57851246/chr17:41234592)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	BRCA1 UIMC1
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	719

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

VMP1

chr17:57851246

chr17:41234592

ENST00000262291

2_43

238.0

407.0

Topological domain

Cytoplasmic

Hgene

VMP1

chr17:57851246

chr17:41234592

ENST00000262291

65_77

238.0

407.0

Topological domain

Extracellular

Hgene

VMP1

chr17:57851246

chr17:41234592

ENST00000262291

99_109

238.0

407.0

Topological domain

Cytoplasmic

Hgene

VMP1

chr17:57851246

chr17:41234592

ENST00000262291

110_130

238.0

407.0

Transmembrane

Helical

Hgene

VMP1

chr17:57851246

chr17:41234592

ENST00000262291

44_64

238.0

407.0

Transmembrane

Helical

Hgene

VMP1

chr17:57851246

chr17:41234592

ENST00000262291

78_98

238.0

407.0

Transmembrane

Helical

Tgene

BRCA1

chr17:57851246

chr17:41234592

ENST00000352993

651_654

253.0

722.0

Compositional bias

Note=Poly-Lys

Tgene

BRCA1

chr17:57851246

chr17:41234592

ENST00000468300

651_654

292.0

700.0

Compositional bias

Note=Poly-Lys

Tgene

BRCA1

chr17:57851246

chr17:41234592

ENST00000491747

651_654

292.0

760.0

Compositional bias

Note=Poly-Lys

Tgene

BRCA1

chr17:57851246

chr17:41234592

ENST00000352993

1642_1736

253.0

722.0

Domain

BRCT 1

Tgene

BRCA1

chr17:57851246

chr17:41234592

ENST00000352993

1756_1855

253.0

722.0

Domain

BRCT 2

Tgene

BRCA1

chr17:57851246

chr17:41234592

ENST00000357654

1642_1736

1395.0

1864.0

Domain

BRCT 1

Tgene

BRCA1

chr17:57851246

chr17:41234592

ENST00000357654

1756_1855

1395.0

1864.0

Domain

BRCT 2

Tgene

BRCA1

chr17:57851246

chr17:41234592

ENST00000468300

1642_1736

292.0

700.0

Domain

BRCT 1

Tgene

BRCA1

chr17:57851246

chr17:41234592

ENST00000468300

1756_1855

292.0

700.0

Domain

BRCT 2

Tgene

BRCA1

chr17:57851246

chr17:41234592

ENST00000491747

1642_1736

292.0

760.0

Domain

BRCT 1

Tgene

BRCA1

chr17:57851246

chr17:41234592

ENST00000491747

1756_1855

292.0

760.0

Domain

BRCT 2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

VMP1

chr17:57851246

chr17:41234592

ENST00000262291

173_316

238.0

407.0

Region

VTT domain

Hgene

VMP1

chr17:57851246

chr17:41234592

ENST00000262291

131_250

238.0

407.0

Topological domain

Extracellular

Hgene

VMP1

chr17:57851246

chr17:41234592

ENST00000262291

272_273

238.0

407.0

Topological domain

Cytoplasmic

Hgene

VMP1

chr17:57851246

chr17:41234592

ENST00000262291

295_305

238.0

407.0

Topological domain

Extracellular

Hgene

VMP1

chr17:57851246

chr17:41234592

ENST00000262291

327_363

238.0

407.0

Topological domain

Cytoplasmic

Hgene

VMP1

chr17:57851246

chr17:41234592

ENST00000262291

385_406

238.0

407.0

Topological domain

Extracellular

Hgene

VMP1

chr17:57851246

chr17:41234592

ENST00000262291

251_271

238.0

407.0

Transmembrane

Helical

Hgene

VMP1

chr17:57851246

chr17:41234592

ENST00000262291

274_294

238.0

407.0

Transmembrane

Helical

Hgene

VMP1

chr17:57851246

chr17:41234592

ENST00000262291

306_326

238.0

407.0

Transmembrane

Helical

Hgene

VMP1

chr17:57851246

chr17:41234592

ENST00000262291

364_384

238.0

407.0

Transmembrane

Helical

Tgene

BRCA1

chr17:57851246

chr17:41234592

ENST00000357654

651_654

1395.0

1864.0

Compositional bias

Note=Poly-Lys

Tgene

BRCA1

chr17:57851246

chr17:41234592

ENST00000352993

24_65

253.0

722.0

Zinc finger

RING-type

Tgene

BRCA1

chr17:57851246

chr17:41234592

ENST00000357654

24_65

1395.0

1864.0

Zinc finger

RING-type

Tgene

BRCA1

chr17:57851246

chr17:41234592

ENST00000468300

24_65

292.0

700.0

Zinc finger

RING-type

Tgene

BRCA1

chr17:57851246

chr17:41234592

ENST00000491747

24_65

292.0

760.0

Zinc finger

RING-type

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
VMP1
BRCA1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to VMP1-BRCA1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to VMP1-BRCA1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source