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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:VMP1-KDM2A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: VMP1-KDM2A
FusionPDB ID: 98202
FusionGDB2.0 ID: 98202
HgeneTgene
Gene symbol

VMP1

KDM2A

Gene ID

81671

22992

Gene namevacuole membrane protein 1lysine demethylase 2A
SynonymsEPG3|TANGO5|TMEM49CXXC8|FBL11|FBL7|FBXL11|JHDM1A|LILINA
Cytomap

17q23.1

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionvacuole membrane protein 1ectopic P-granules autophagy protein 3 homologtransmembrane protein 49transport and golgi organization 5 homologlysine-specific demethylase 2ACXXC-type zinc finger protein 8F-box and leucine-rich repeat protein 11F-box/LRR-repeat protein 11[Histone-H3]-lysine-36 demethylase 1AjmjC domain-containing histone demethylation protein 1Ajumonji C domain-containing h
Modification date2020032720200320
UniProtAcc.

Q9Y2K7

Ensembl transtripts involved in fusion geneENST idsENST00000262291, ENST00000536180, 
ENST00000537567, ENST00000539763, 
ENST00000545362, ENST00000588617, 
ENST00000308783, ENST00000526258, 
ENST00000530342, ENST00000398645, 
ENST00000529006, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score34 X 17 X 12=693628 X 27 X 8=6048
# samples 3832
** MAII scorelog2(38/6936*10)=-4.19003257489089
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/6048*10)=-4.24031432933371
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: VMP1 [Title/Abstract] AND KDM2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)VMP1(57851246)-KDM2A(66947550), # samples:2
Anticipated loss of major functional domain due to fusion event.VMP1-KDM2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
VMP1-KDM2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
VMP1-KDM2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
VMP1-KDM2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across VMP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KDM2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A1-A0SN-01AVMP1chr17

57851246

+KDM2Achr11

66947550

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262291VMP1chr1757851246+ENST00000398645KDM2Achr1166947550+6629102425333301025
ENST00000262291VMP1chr1757851246+ENST00000529006KDM2Achr1166947550+7503102425344701405
ENST00000537567VMP1chr1757851246+ENST00000398645KDM2Achr1166947550+62446393272945872
ENST00000537567VMP1chr1757851246+ENST00000529006KDM2Achr1166947550+711863932740851252
ENST00000539763VMP1chr1757851246+ENST00000398645KDM2Achr1166947550+63087032383009923
ENST00000539763VMP1chr1757851246+ENST00000529006KDM2Achr1166947550+718270323841491303
ENST00000536180VMP1chr1757851246+ENST00000398645KDM2Achr1166947550+63387333103039909
ENST00000536180VMP1chr1757851246+ENST00000529006KDM2Achr1166947550+721273331041791289
ENST00000545362VMP1chr1757851246+ENST00000398645KDM2Achr1166947550+6204599412905954
ENST00000545362VMP1chr1757851246+ENST00000529006KDM2Achr1166947550+70785994140451334

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262291ENST00000398645VMP1chr1757851246+KDM2Achr1166947550+0.0006494430.9993506
ENST00000262291ENST00000529006VMP1chr1757851246+KDM2Achr1166947550+0.0004236050.9995764
ENST00000537567ENST00000398645VMP1chr1757851246+KDM2Achr1166947550+0.0009148380.9990852
ENST00000537567ENST00000529006VMP1chr1757851246+KDM2Achr1166947550+0.0004323160.9995677
ENST00000539763ENST00000398645VMP1chr1757851246+KDM2Achr1166947550+0.0012625890.9987374
ENST00000539763ENST00000529006VMP1chr1757851246+KDM2Achr1166947550+0.0005617720.9994382
ENST00000536180ENST00000398645VMP1chr1757851246+KDM2Achr1166947550+0.0007779990.99922204
ENST00000536180ENST00000529006VMP1chr1757851246+KDM2Achr1166947550+0.0004400930.99955994
ENST00000545362ENST00000398645VMP1chr1757851246+KDM2Achr1166947550+0.0008127030.9991873
ENST00000545362ENST00000529006VMP1chr1757851246+KDM2Achr1166947550+0.0003114570.9996885

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>98202_98202_1_VMP1-KDM2A_VMP1_chr17_57851246_ENST00000262291_KDM2A_chr11_66947550_ENST00000398645_length(amino acids)=1025AA_BP=257
MRSGAAGVGAAPQELLIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSK
LWHRQSIVVSFLLLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPP
YPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQRGTMRRRYEDDGI
SDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQK
GIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGC
YTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGG
NFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESGNGDEEAVDREPRRLSS
RRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKC
VPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARRR
RVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMD
GEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVSPRGMVTRSSPGAGPSD

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>98202_98202_2_VMP1-KDM2A_VMP1_chr17_57851246_ENST00000262291_KDM2A_chr11_66947550_ENST00000529006_length(amino acids)=1405AA_BP=257
MRSGAAGVGAAPQELLIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSK
LWHRQSIVVSFLLLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPP
YPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQRGTMRRRYEDDGI
SDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQK
GIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGC
YTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGG
NFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESGNGDEEAVDREPRRLSS
RRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKC
VPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARRR
RVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMD
GEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVSPRGMVTRSSPGAGPSD
HHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLV
QHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDK
RLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDP
QIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKL

--------------------------------------------------------------

>98202_98202_3_VMP1-KDM2A_VMP1_chr17_57851246_ENST00000536180_KDM2A_chr11_66947550_ENST00000398645_length(amino acids)=909AA_BP=141
MDLKYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKV
RIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANF
VTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNV
ISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWL
IPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNK
FRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRS
LPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSD
PKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKK
FGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEK
AQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMV

--------------------------------------------------------------

>98202_98202_4_VMP1-KDM2A_VMP1_chr17_57851246_ENST00000536180_KDM2A_chr11_66947550_ENST00000529006_length(amino acids)=1289AA_BP=141
MDLKYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKV
RIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANF
VTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNV
ISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWL
IPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNK
FRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRS
LPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSD
PKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKK
FGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEK
AQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMV
REKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLVQHCPARTPQRGDEEGLGGEEEEEEEE
EEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQ
PVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTD
FRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQIT

--------------------------------------------------------------

>98202_98202_5_VMP1-KDM2A_VMP1_chr17_57851246_ENST00000537567_KDM2A_chr11_66947550_ENST00000398645_length(amino acids)=872AA_BP=104
MDLKGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEY
QEFEEMLEHAESAQRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPD
PDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKES
QTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIEL
KQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLS
MDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQ
VHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKP
HTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNE
ETQDFEKKLMECCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPT

--------------------------------------------------------------

>98202_98202_6_VMP1-KDM2A_VMP1_chr17_57851246_ENST00000537567_KDM2A_chr11_66947550_ENST00000529006_length(amino acids)=1252AA_BP=104
MDLKGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEGTEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEY
QEFEEMLEHAESAQRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPD
PDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKES
QTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIEL
KQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLS
MDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQ
VHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKP
HTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNE
ETQDFEKKLMECCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPT
SMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKEL
HGTSIVPKLQAITASSANLRHSPRVLVQHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMS
VFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWS
AVSALSTSSCPLLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQ

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>98202_98202_7_VMP1-KDM2A_VMP1_chr17_57851246_ENST00000539763_KDM2A_chr11_66947550_ENST00000398645_length(amino acids)=923AA_BP=155
MLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEG
TEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQRGTMRRRYEDDGISDDEIEGKRTFD
LEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRY
YETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTS
VWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQL
KIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANG
VNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALI
ADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQ
GECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEGLLNEELPNC
WECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKR

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>98202_98202_8_VMP1-KDM2A_VMP1_chr17_57851246_ENST00000539763_KDM2A_chr11_66947550_ENST00000529006_length(amino acids)=1303AA_BP=155
MLLAVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECNSVNFPEPPYPDQIICPDEEG
TEGTISLWSIISKVRIEACMWGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLEHAESAQRGTMRRRYEDDGISDDEIEGKRTFD
LEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRY
YETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTS
VWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQL
KIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANG
VNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALI
ADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQ
GECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEGLLNEELPNC
WECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKR
RQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLVQHCPARTPQRGD
EEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCK
AIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIRDLLTPPADK
PGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIA

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>98202_98202_9_VMP1-KDM2A_VMP1_chr17_57851246_ENST00000545362_KDM2A_chr11_66947550_ENST00000398645_length(amino acids)=954AA_BP=186
MIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLL
AVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLE
HAESAQRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDV
KMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAI
LEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVI
PSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGL
ESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFEL
EGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPR
LTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKK
LMECCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHD

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>98202_98202_10_VMP1-KDM2A_VMP1_chr17_57851246_ENST00000545362_KDM2A_chr11_66947550_ENST00000529006_length(amino acids)=1334AA_BP=186
MIYEMAENGKNCDQRRVAMNKEHHNGNFTDPSSVNEKKRREREERQNIVLWRQPLITLQYFSLEILVILKEWTSKLWHRQSIVVSFLLLL
AVLIATYYVEGVHQQYVQRIEKQFLLYAYWIGLGILSSVGLGTGLHTFLLYLGIGTAIGELPPYFMARAARLSGAEPDDEEYQEFEEMLE
HAESAQRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDV
KMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTESTNAI
LEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVI
PSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLSMDLELNGL
ESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKTLAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFEL
EGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPR
LTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKK
LMECCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPTSMLQLIHD
PVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPK
LQAITASSANLRHSPRVLVQHCPARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRR
ELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTS
SCPLLRTLDLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAV

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:57851246/chr11:66947550)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KDM2A

Q9Y2K7

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-ARNTL/BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVMP1chr17:57851246chr11:66947550ENST00000262291+7122_43238.0407.0Topological domainCytoplasmic
HgeneVMP1chr17:57851246chr11:66947550ENST00000262291+71265_77238.0407.0Topological domainExtracellular
HgeneVMP1chr17:57851246chr11:66947550ENST00000262291+71299_109238.0407.0Topological domainCytoplasmic
HgeneVMP1chr17:57851246chr11:66947550ENST00000262291+712110_130238.0407.0TransmembraneHelical
HgeneVMP1chr17:57851246chr11:66947550ENST00000262291+71244_64238.0407.0TransmembraneHelical
HgeneVMP1chr17:57851246chr11:66947550ENST00000262291+71278_98238.0407.0TransmembraneHelical
TgeneKDM2Achr17:57851246chr11:66947550ENST00000308783010148_3160621.0DomainJmjC
TgeneKDM2Achr17:57851246chr11:66947550ENST00000308783010889_9360621.0DomainNote=F-box
TgeneKDM2Achr17:57851246chr11:66947550ENST00000398645121148_31614.01490.3333333333333DomainJmjC
TgeneKDM2Achr17:57851246chr11:66947550ENST00000398645121889_93614.01490.3333333333333DomainNote=F-box
TgeneKDM2Achr17:57851246chr11:66947550ENST00000529006121148_31614.01163.0DomainJmjC
TgeneKDM2Achr17:57851246chr11:66947550ENST00000529006121889_93614.01163.0DomainNote=F-box
TgeneKDM2Achr17:57851246chr11:66947550ENST00000530342010148_3160724.0DomainJmjC
TgeneKDM2Achr17:57851246chr11:66947550ENST00000530342010889_9360724.0DomainNote=F-box
TgeneKDM2Achr17:57851246chr11:66947550ENST000003087830101048_10730621.0RepeatNote=LRR 3
TgeneKDM2Achr17:57851246chr11:66947550ENST000003087830101074_11030621.0RepeatNote=LRR 4
TgeneKDM2Achr17:57851246chr11:66947550ENST000003087830101104_11280621.0RepeatNote=LRR 5
TgeneKDM2Achr17:57851246chr11:66947550ENST000003087830101129_11560621.0RepeatNote=LRR 6
TgeneKDM2Achr17:57851246chr11:66947550ENST00000308783010961_9820621.0RepeatNote=LRR 1
TgeneKDM2Achr17:57851246chr11:66947550ENST00000308783010984_10100621.0RepeatNote=LRR 2
TgeneKDM2Achr17:57851246chr11:66947550ENST000003986451211048_107314.01490.3333333333333RepeatNote=LRR 3
TgeneKDM2Achr17:57851246chr11:66947550ENST000003986451211074_110314.01490.3333333333333RepeatNote=LRR 4
TgeneKDM2Achr17:57851246chr11:66947550ENST000003986451211104_112814.01490.3333333333333RepeatNote=LRR 5
TgeneKDM2Achr17:57851246chr11:66947550ENST000003986451211129_115614.01490.3333333333333RepeatNote=LRR 6
TgeneKDM2Achr17:57851246chr11:66947550ENST00000398645121961_98214.01490.3333333333333RepeatNote=LRR 1
TgeneKDM2Achr17:57851246chr11:66947550ENST00000398645121984_101014.01490.3333333333333RepeatNote=LRR 2
TgeneKDM2Achr17:57851246chr11:66947550ENST000005290061211048_107314.01163.0RepeatNote=LRR 3
TgeneKDM2Achr17:57851246chr11:66947550ENST000005290061211074_110314.01163.0RepeatNote=LRR 4
TgeneKDM2Achr17:57851246chr11:66947550ENST000005290061211104_112814.01163.0RepeatNote=LRR 5
TgeneKDM2Achr17:57851246chr11:66947550ENST000005290061211129_115614.01163.0RepeatNote=LRR 6
TgeneKDM2Achr17:57851246chr11:66947550ENST00000529006121961_98214.01163.0RepeatNote=LRR 1
TgeneKDM2Achr17:57851246chr11:66947550ENST00000529006121984_101014.01163.0RepeatNote=LRR 2
TgeneKDM2Achr17:57851246chr11:66947550ENST000005303420101048_10730724.0RepeatNote=LRR 3
TgeneKDM2Achr17:57851246chr11:66947550ENST000005303420101074_11030724.0RepeatNote=LRR 4
TgeneKDM2Achr17:57851246chr11:66947550ENST000005303420101104_11280724.0RepeatNote=LRR 5
TgeneKDM2Achr17:57851246chr11:66947550ENST000005303420101129_11560724.0RepeatNote=LRR 6
TgeneKDM2Achr17:57851246chr11:66947550ENST00000530342010961_9820724.0RepeatNote=LRR 1
TgeneKDM2Achr17:57851246chr11:66947550ENST00000530342010984_10100724.0RepeatNote=LRR 2
TgeneKDM2Achr17:57851246chr11:66947550ENST00000308783010564_6100621.0Zinc fingerCXXC-type
TgeneKDM2Achr17:57851246chr11:66947550ENST00000308783010617_6780621.0Zinc fingerPHD-type
TgeneKDM2Achr17:57851246chr11:66947550ENST00000398645121564_61014.01490.3333333333333Zinc fingerCXXC-type
TgeneKDM2Achr17:57851246chr11:66947550ENST00000398645121617_67814.01490.3333333333333Zinc fingerPHD-type
TgeneKDM2Achr17:57851246chr11:66947550ENST00000529006121564_61014.01163.0Zinc fingerCXXC-type
TgeneKDM2Achr17:57851246chr11:66947550ENST00000529006121617_67814.01163.0Zinc fingerPHD-type
TgeneKDM2Achr17:57851246chr11:66947550ENST00000530342010564_6100724.0Zinc fingerCXXC-type
TgeneKDM2Achr17:57851246chr11:66947550ENST00000530342010617_6780724.0Zinc fingerPHD-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneVMP1chr17:57851246chr11:66947550ENST00000262291+712173_316238.0407.0RegionVTT domain
HgeneVMP1chr17:57851246chr11:66947550ENST00000262291+712131_250238.0407.0Topological domainExtracellular
HgeneVMP1chr17:57851246chr11:66947550ENST00000262291+712272_273238.0407.0Topological domainCytoplasmic
HgeneVMP1chr17:57851246chr11:66947550ENST00000262291+712295_305238.0407.0Topological domainExtracellular
HgeneVMP1chr17:57851246chr11:66947550ENST00000262291+712327_363238.0407.0Topological domainCytoplasmic
HgeneVMP1chr17:57851246chr11:66947550ENST00000262291+712385_406238.0407.0Topological domainExtracellular
HgeneVMP1chr17:57851246chr11:66947550ENST00000262291+712251_271238.0407.0TransmembraneHelical
HgeneVMP1chr17:57851246chr11:66947550ENST00000262291+712274_294238.0407.0TransmembraneHelical
HgeneVMP1chr17:57851246chr11:66947550ENST00000262291+712306_326238.0407.0TransmembraneHelical
HgeneVMP1chr17:57851246chr11:66947550ENST00000262291+712364_384238.0407.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
VMP1
KDM2A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to VMP1-KDM2A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to VMP1-KDM2A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource