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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:VPS33A-ABCB9

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: VPS33A-ABCB9
FusionPDB ID: 98375
FusionGDB2.0 ID: 98375
HgeneTgene
Gene symbol

VPS33A

ABCB9

Gene ID

65082

23457

Gene nameVPS33A core subunit of CORVET and HOPS complexesATP binding cassette subfamily B member 9
SynonymsMPSPSEST122234|TAPL
Cytomap

12q24.31

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionvacuolar protein sorting-associated protein 33AVPS33A, CORVET/HOPS core subunitvacuolar protein sorting 33 homolog Avacuolar protein sorting 33AATP-binding cassette sub-family B member 9ABC transporter 9 proteinATP-binding cassette, sub-family B (MDR/TAP), member 9TAP-like protein
Modification date2020031320200313
UniProtAcc.

Q9NP78

Ensembl transtripts involved in fusion geneENST idsENST00000267199, ENST00000451053, 
ENST00000542310, 		ENST00000541983, 
ENST00000280560, ENST00000344275, 
ENST00000346530, ENST00000392439, 
ENST00000442028, ENST00000442833, 
ENST00000540285, ENST00000542678, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 8 X 5=2403 X 3 X 3=27
# samples 85
** MAII scorelog2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/27*10)=0.888968687611256
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: VPS33A [Title/Abstract] AND ABCB9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)VPS33A(122734417)-ABCB9(123435112), # samples:2
Anticipated loss of major functional domain due to fusion event.VPS33A-ABCB9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
VPS33A-ABCB9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
VPS33A-ABCB9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
VPS33A-ABCB9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneVPS33A

GO:0016192

vesicle-mediated transport

15790593

HgeneVPS33A

GO:0032400

melanosome localization

15790593

HgeneVPS33A

GO:0032418

lysosome localization

15790593

TgeneABCB9

GO:0002474

antigen processing and presentation of peptide antigen via MHC class I

17977821

TgeneABCB9

GO:0015833

peptide transport

17977821|18434309|22641697


check buttonFusion gene breakpoints across VPS33A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ABCB9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A4OQ-01AVPS33Achr12

122734418

-ABCB9chr12

123435112

-
ChimerDB4ESCATCGA-L5-A4OQVPS33Achr12

122734417

-ABCB9chr12

123435112

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000267199VPS33Achr12122734418-ENST00000344275ABCB9chr12123435112-2420888412332763
ENST00000267199VPS33Achr12122734418-ENST00000442833ABCB9chr12123435112-2613888412338765
ENST00000267199VPS33Achr12122734418-ENST00000280560ABCB9chr12123435112-3505888412587848
ENST00000267199VPS33Achr12122734418-ENST00000540285ABCB9chr12123435112-3316888412398785
ENST00000267199VPS33Achr12122734418-ENST00000346530ABCB9chr12123435112-3376888412458805
ENST00000267199VPS33Achr12122734418-ENST00000392439ABCB9chr12123435112-3500888412587848
ENST00000267199VPS33Achr12122734418-ENST00000442028ABCB9chr12123435112-3508888412596851
ENST00000267199VPS33Achr12122734418-ENST00000542678ABCB9chr12123435112-3499888412587848
ENST00000267199VPS33Achr12122734417-ENST00000344275ABCB9chr12123435112-2420888412332763
ENST00000267199VPS33Achr12122734417-ENST00000442833ABCB9chr12123435112-2613888412338765
ENST00000267199VPS33Achr12122734417-ENST00000280560ABCB9chr12123435112-3505888412587848
ENST00000267199VPS33Achr12122734417-ENST00000540285ABCB9chr12123435112-3316888412398785
ENST00000267199VPS33Achr12122734417-ENST00000346530ABCB9chr12123435112-3376888412458805
ENST00000267199VPS33Achr12122734417-ENST00000392439ABCB9chr12123435112-3500888412587848
ENST00000267199VPS33Achr12122734417-ENST00000442028ABCB9chr12123435112-3508888412596851
ENST00000267199VPS33Achr12122734417-ENST00000542678ABCB9chr12123435112-3499888412587848

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000267199ENST00000344275VPS33Achr12122734418-ABCB9chr12123435112-0.0080306620.9919694
ENST00000267199ENST00000442833VPS33Achr12122734418-ABCB9chr12123435112-0.0052107030.99478936
ENST00000267199ENST00000280560VPS33Achr12122734418-ABCB9chr12123435112-0.0045426130.9954574
ENST00000267199ENST00000540285VPS33Achr12122734418-ABCB9chr12123435112-0.0065965520.9934035
ENST00000267199ENST00000346530VPS33Achr12122734418-ABCB9chr12123435112-0.0056595080.9943404
ENST00000267199ENST00000392439VPS33Achr12122734418-ABCB9chr12123435112-0.0045954120.9954046
ENST00000267199ENST00000442028VPS33Achr12122734418-ABCB9chr12123435112-0.0046352150.9953648
ENST00000267199ENST00000542678VPS33Achr12122734418-ABCB9chr12123435112-0.0046604380.9953395
ENST00000267199ENST00000344275VPS33Achr12122734417-ABCB9chr12123435112-0.0080306620.9919694
ENST00000267199ENST00000442833VPS33Achr12122734417-ABCB9chr12123435112-0.0052107030.99478936
ENST00000267199ENST00000280560VPS33Achr12122734417-ABCB9chr12123435112-0.0045426130.9954574
ENST00000267199ENST00000540285VPS33Achr12122734417-ABCB9chr12123435112-0.0065965520.9934035
ENST00000267199ENST00000346530VPS33Achr12122734417-ABCB9chr12123435112-0.0056595080.9943404
ENST00000267199ENST00000392439VPS33Achr12122734417-ABCB9chr12123435112-0.0045954120.9954046
ENST00000267199ENST00000442028VPS33Achr12122734417-ABCB9chr12123435112-0.0046352150.9953648
ENST00000267199ENST00000542678VPS33Achr12122734417-ABCB9chr12123435112-0.0046604380.9953395

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>98375_98375_1_VPS33A-ABCB9_VPS33A_chr12_122734417_ENST00000267199_ABCB9_chr12_123435112_ENST00000280560_length(amino acids)=848AA_BP=283
MRPWSSRRNRRTRLALWGRGWWSKMAAHLSYGRVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTL
KGNRLPAADVKNIIFFVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMES
EGAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMIRMKREFTGSQNSIFPVFDNLLLLDRNVDLLTPLATQLTY
EGLIDEIYGIQNRETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFD
ENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTA
EETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDC
MESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSC
VNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE
KGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLL

--------------------------------------------------------------

>98375_98375_2_VPS33A-ABCB9_VPS33A_chr12_122734417_ENST00000267199_ABCB9_chr12_123435112_ENST00000344275_length(amino acids)=763AA_BP=283
MRPWSSRRNRRTRLALWGRGWWSKMAAHLSYGRVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTL
KGNRLPAADVKNIIFFVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMES
EGAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMIRMKREFTGSQNSIFPVFDNLLLLDRNVDLLTPLATQLTY
EGLIDEIYGIQNRETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFD
ENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTA
EETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDC
MESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSC
VNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE

--------------------------------------------------------------

>98375_98375_3_VPS33A-ABCB9_VPS33A_chr12_122734417_ENST00000267199_ABCB9_chr12_123435112_ENST00000346530_length(amino acids)=805AA_BP=283
MRPWSSRRNRRTRLALWGRGWWSKMAAHLSYGRVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTL
KGNRLPAADVKNIIFFVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMES
EGAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMIRMKREFTGSQNSIFPVFDNLLLLDRNVDLLTPLATQLTY
EGLIDEIYGIQNRETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFD
ENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTA
EETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGSVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLE
GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVL
FARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLI

--------------------------------------------------------------

>98375_98375_4_VPS33A-ABCB9_VPS33A_chr12_122734417_ENST00000267199_ABCB9_chr12_123435112_ENST00000392439_length(amino acids)=848AA_BP=283
MRPWSSRRNRRTRLALWGRGWWSKMAAHLSYGRVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTL
KGNRLPAADVKNIIFFVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMES
EGAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMIRMKREFTGSQNSIFPVFDNLLLLDRNVDLLTPLATQLTY
EGLIDEIYGIQNRETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFD
ENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTA
EETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDC
MESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSC
VNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE
KGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLL

--------------------------------------------------------------

>98375_98375_5_VPS33A-ABCB9_VPS33A_chr12_122734417_ENST00000267199_ABCB9_chr12_123435112_ENST00000442028_length(amino acids)=851AA_BP=283
MRPWSSRRNRRTRLALWGRGWWSKMAAHLSYGRVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTL
KGNRLPAADVKNIIFFVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMES
EGAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMIRMKREFTGSQNSIFPVFDNLLLLDRNVDLLTPLATQLTY
EGLIDEIYGIQNRETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFD
ENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTA
EETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDC
MESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSC
VNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE
KGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLSPQIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQ

--------------------------------------------------------------

>98375_98375_6_VPS33A-ABCB9_VPS33A_chr12_122734417_ENST00000267199_ABCB9_chr12_123435112_ENST00000442833_length(amino acids)=765AA_BP=283
MRPWSSRRNRRTRLALWGRGWWSKMAAHLSYGRVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTL
KGNRLPAADVKNIIFFVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMES
EGAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMIRMKREFTGSQNSIFPVFDNLLLLDRNVDLLTPLATQLTY
EGLIDEIYGIQNRETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFD
ENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTA
EETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDC
MESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSC
VNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE

--------------------------------------------------------------

>98375_98375_7_VPS33A-ABCB9_VPS33A_chr12_122734417_ENST00000267199_ABCB9_chr12_123435112_ENST00000540285_length(amino acids)=785AA_BP=283
MRPWSSRRNRRTRLALWGRGWWSKMAAHLSYGRVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTL
KGNRLPAADVKNIIFFVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMES
EGAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMIRMKREFTGSQNSIFPVFDNLLLLDRNVDLLTPLATQLTY
EGLIDEIYGIQNRETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFD
ENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTA
EETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDC
MENVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEM
VVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRL

--------------------------------------------------------------

>98375_98375_8_VPS33A-ABCB9_VPS33A_chr12_122734417_ENST00000267199_ABCB9_chr12_123435112_ENST00000542678_length(amino acids)=848AA_BP=283
MRPWSSRRNRRTRLALWGRGWWSKMAAHLSYGRVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTL
KGNRLPAADVKNIIFFVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMES
EGAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMIRMKREFTGSQNSIFPVFDNLLLLDRNVDLLTPLATQLTY
EGLIDEIYGIQNRETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFD
ENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTA
EETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDC
MESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSC
VNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE
KGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLL

--------------------------------------------------------------

>98375_98375_9_VPS33A-ABCB9_VPS33A_chr12_122734418_ENST00000267199_ABCB9_chr12_123435112_ENST00000280560_length(amino acids)=848AA_BP=283
MRPWSSRRNRRTRLALWGRGWWSKMAAHLSYGRVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTL
KGNRLPAADVKNIIFFVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMES
EGAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMIRMKREFTGSQNSIFPVFDNLLLLDRNVDLLTPLATQLTY
EGLIDEIYGIQNRETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFD
ENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTA
EETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDC
MESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSC
VNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE
KGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLL

--------------------------------------------------------------

>98375_98375_10_VPS33A-ABCB9_VPS33A_chr12_122734418_ENST00000267199_ABCB9_chr12_123435112_ENST00000344275_length(amino acids)=763AA_BP=283
MRPWSSRRNRRTRLALWGRGWWSKMAAHLSYGRVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTL
KGNRLPAADVKNIIFFVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMES
EGAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMIRMKREFTGSQNSIFPVFDNLLLLDRNVDLLTPLATQLTY
EGLIDEIYGIQNRETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFD
ENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTA
EETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDC
MESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSC
VNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE

--------------------------------------------------------------

>98375_98375_11_VPS33A-ABCB9_VPS33A_chr12_122734418_ENST00000267199_ABCB9_chr12_123435112_ENST00000346530_length(amino acids)=805AA_BP=283
MRPWSSRRNRRTRLALWGRGWWSKMAAHLSYGRVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTL
KGNRLPAADVKNIIFFVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMES
EGAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMIRMKREFTGSQNSIFPVFDNLLLLDRNVDLLTPLATQLTY
EGLIDEIYGIQNRETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFD
ENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTA
EETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGSVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLE
GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVL
FARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLI

--------------------------------------------------------------

>98375_98375_12_VPS33A-ABCB9_VPS33A_chr12_122734418_ENST00000267199_ABCB9_chr12_123435112_ENST00000392439_length(amino acids)=848AA_BP=283
MRPWSSRRNRRTRLALWGRGWWSKMAAHLSYGRVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTL
KGNRLPAADVKNIIFFVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMES
EGAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMIRMKREFTGSQNSIFPVFDNLLLLDRNVDLLTPLATQLTY
EGLIDEIYGIQNRETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFD
ENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTA
EETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDC
MESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSC
VNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE
KGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLL

--------------------------------------------------------------

>98375_98375_13_VPS33A-ABCB9_VPS33A_chr12_122734418_ENST00000267199_ABCB9_chr12_123435112_ENST00000442028_length(amino acids)=851AA_BP=283
MRPWSSRRNRRTRLALWGRGWWSKMAAHLSYGRVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTL
KGNRLPAADVKNIIFFVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMES
EGAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMIRMKREFTGSQNSIFPVFDNLLLLDRNVDLLTPLATQLTY
EGLIDEIYGIQNRETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFD
ENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTA
EETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDC
MESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSC
VNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE
KGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLSPQIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQ

--------------------------------------------------------------

>98375_98375_14_VPS33A-ABCB9_VPS33A_chr12_122734418_ENST00000267199_ABCB9_chr12_123435112_ENST00000442833_length(amino acids)=765AA_BP=283
MRPWSSRRNRRTRLALWGRGWWSKMAAHLSYGRVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTL
KGNRLPAADVKNIIFFVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMES
EGAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMIRMKREFTGSQNSIFPVFDNLLLLDRNVDLLTPLATQLTY
EGLIDEIYGIQNRETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFD
ENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTA
EETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDC
MESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSC
VNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE

--------------------------------------------------------------

>98375_98375_15_VPS33A-ABCB9_VPS33A_chr12_122734418_ENST00000267199_ABCB9_chr12_123435112_ENST00000540285_length(amino acids)=785AA_BP=283
MRPWSSRRNRRTRLALWGRGWWSKMAAHLSYGRVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTL
KGNRLPAADVKNIIFFVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMES
EGAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMIRMKREFTGSQNSIFPVFDNLLLLDRNVDLLTPLATQLTY
EGLIDEIYGIQNRETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFD
ENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTA
EETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDC
MENVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEM
VVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRL

--------------------------------------------------------------

>98375_98375_16_VPS33A-ABCB9_VPS33A_chr12_122734418_ENST00000267199_ABCB9_chr12_123435112_ENST00000542678_length(amino acids)=848AA_BP=283
MRPWSSRRNRRTRLALWGRGWWSKMAAHLSYGRVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTL
KGNRLPAADVKNIIFFVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMES
EGAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMIRMKREFTGSQNSIFPVFDNLLLLDRNVDLLTPLATQLTY
EGLIDEIYGIQNRETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFD
ENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTA
EETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDC
MESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSC
VNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGE
KGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLL

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:122734417/chr12:123435112)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ABCB9

Q9NP78

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. {ECO:0000269|PubMed:15863492, ECO:0000269|PubMed:17977821, ECO:0000269|PubMed:18434309}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABCB9chr12:122734417chr12:123435112ENST00000280560112384_389200.33333333333334767.0Compositional biasNote=Poly-Glu
TgeneABCB9chr12:122734417chr12:123435112ENST00000344275112384_389200.33333333333334682.0Compositional biasNote=Poly-Glu
TgeneABCB9chr12:122734417chr12:123435112ENST00000346530111384_389200.33333333333334724.0Compositional biasNote=Poly-Glu
TgeneABCB9chr12:122734417chr12:123435112ENST00000392439112384_389200.33333333333334767.0Compositional biasNote=Poly-Glu
TgeneABCB9chr12:122734417chr12:123435112ENST00000442833112384_389200.33333333333334684.0Compositional biasNote=Poly-Glu
TgeneABCB9chr12:122734417chr12:123435112ENST00000540285111384_389200.33333333333334704.0Compositional biasNote=Poly-Glu
TgeneABCB9chr12:122734417chr12:123435112ENST00000542678112384_389200.33333333333334767.0Compositional biasNote=Poly-Glu
TgeneABCB9chr12:122734418chr12:123435112ENST00000280560112384_389200.33333333333334767.0Compositional biasNote=Poly-Glu
TgeneABCB9chr12:122734418chr12:123435112ENST00000344275112384_389200.33333333333334682.0Compositional biasNote=Poly-Glu
TgeneABCB9chr12:122734418chr12:123435112ENST00000346530111384_389200.33333333333334724.0Compositional biasNote=Poly-Glu
TgeneABCB9chr12:122734418chr12:123435112ENST00000392439112384_389200.33333333333334767.0Compositional biasNote=Poly-Glu
TgeneABCB9chr12:122734418chr12:123435112ENST00000442833112384_389200.33333333333334684.0Compositional biasNote=Poly-Glu
TgeneABCB9chr12:122734418chr12:123435112ENST00000540285111384_389200.33333333333334704.0Compositional biasNote=Poly-Glu
TgeneABCB9chr12:122734418chr12:123435112ENST00000542678112384_389200.33333333333334767.0Compositional biasNote=Poly-Glu
TgeneABCB9chr12:122734417chr12:123435112ENST00000280560112504_740200.33333333333334767.0DomainABC transporter
TgeneABCB9chr12:122734417chr12:123435112ENST00000344275112504_740200.33333333333334682.0DomainABC transporter
TgeneABCB9chr12:122734417chr12:123435112ENST00000346530111504_740200.33333333333334724.0DomainABC transporter
TgeneABCB9chr12:122734417chr12:123435112ENST00000392439112504_740200.33333333333334767.0DomainABC transporter
TgeneABCB9chr12:122734417chr12:123435112ENST00000442833112504_740200.33333333333334684.0DomainABC transporter
TgeneABCB9chr12:122734417chr12:123435112ENST00000540285111504_740200.33333333333334704.0DomainABC transporter
TgeneABCB9chr12:122734417chr12:123435112ENST00000542678112504_740200.33333333333334767.0DomainABC transporter
TgeneABCB9chr12:122734418chr12:123435112ENST00000280560112504_740200.33333333333334767.0DomainABC transporter
TgeneABCB9chr12:122734418chr12:123435112ENST00000344275112504_740200.33333333333334682.0DomainABC transporter
TgeneABCB9chr12:122734418chr12:123435112ENST00000346530111504_740200.33333333333334724.0DomainABC transporter
TgeneABCB9chr12:122734418chr12:123435112ENST00000392439112504_740200.33333333333334767.0DomainABC transporter
TgeneABCB9chr12:122734418chr12:123435112ENST00000442833112504_740200.33333333333334684.0DomainABC transporter
TgeneABCB9chr12:122734418chr12:123435112ENST00000540285111504_740200.33333333333334704.0DomainABC transporter
TgeneABCB9chr12:122734418chr12:123435112ENST00000542678112504_740200.33333333333334767.0DomainABC transporter
TgeneABCB9chr12:122734417chr12:123435112ENST00000280560112539_546200.33333333333334767.0Nucleotide bindingATP
TgeneABCB9chr12:122734417chr12:123435112ENST00000344275112539_546200.33333333333334682.0Nucleotide bindingATP
TgeneABCB9chr12:122734417chr12:123435112ENST00000346530111539_546200.33333333333334724.0Nucleotide bindingATP
TgeneABCB9chr12:122734417chr12:123435112ENST00000392439112539_546200.33333333333334767.0Nucleotide bindingATP
TgeneABCB9chr12:122734417chr12:123435112ENST00000442833112539_546200.33333333333334684.0Nucleotide bindingATP
TgeneABCB9chr12:122734417chr12:123435112ENST00000540285111539_546200.33333333333334704.0Nucleotide bindingATP
TgeneABCB9chr12:122734417chr12:123435112ENST00000542678112539_546200.33333333333334767.0Nucleotide bindingATP
TgeneABCB9chr12:122734418chr12:123435112ENST00000280560112539_546200.33333333333334767.0Nucleotide bindingATP
TgeneABCB9chr12:122734418chr12:123435112ENST00000344275112539_546200.33333333333334682.0Nucleotide bindingATP
TgeneABCB9chr12:122734418chr12:123435112ENST00000346530111539_546200.33333333333334724.0Nucleotide bindingATP
TgeneABCB9chr12:122734418chr12:123435112ENST00000392439112539_546200.33333333333334767.0Nucleotide bindingATP
TgeneABCB9chr12:122734418chr12:123435112ENST00000442833112539_546200.33333333333334684.0Nucleotide bindingATP
TgeneABCB9chr12:122734418chr12:123435112ENST00000540285111539_546200.33333333333334704.0Nucleotide bindingATP
TgeneABCB9chr12:122734418chr12:123435112ENST00000542678112539_546200.33333333333334767.0Nucleotide bindingATP
TgeneABCB9chr12:122734417chr12:123435112ENST00000280560112225_245200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000280560112319_339200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000280560112416_436200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000344275112225_245200.33333333333334682.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000344275112319_339200.33333333333334682.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000344275112416_436200.33333333333334682.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000346530111225_245200.33333333333334724.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000346530111319_339200.33333333333334724.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000346530111416_436200.33333333333334724.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000392439112225_245200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000392439112319_339200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000392439112416_436200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000442833112225_245200.33333333333334684.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000442833112319_339200.33333333333334684.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000442833112416_436200.33333333333334684.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000540285111225_245200.33333333333334704.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000540285111319_339200.33333333333334704.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000540285111416_436200.33333333333334704.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000542678112225_245200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000542678112319_339200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000542678112416_436200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000280560112225_245200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000280560112319_339200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000280560112416_436200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000344275112225_245200.33333333333334682.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000344275112319_339200.33333333333334682.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000344275112416_436200.33333333333334682.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000346530111225_245200.33333333333334724.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000346530111319_339200.33333333333334724.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000346530111416_436200.33333333333334724.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000392439112225_245200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000392439112319_339200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000392439112416_436200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000442833112225_245200.33333333333334684.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000442833112319_339200.33333333333334684.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000442833112416_436200.33333333333334684.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000540285111225_245200.33333333333334704.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000540285111319_339200.33333333333334704.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000540285111416_436200.33333333333334704.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000542678112225_245200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000542678112319_339200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000542678112416_436200.33333333333334767.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneABCB9chr12:122734417chr12:123435112ENST00000280560112188_471200.33333333333334767.0DomainABC transmembrane type-1
TgeneABCB9chr12:122734417chr12:123435112ENST00000344275112188_471200.33333333333334682.0DomainABC transmembrane type-1
TgeneABCB9chr12:122734417chr12:123435112ENST00000346530111188_471200.33333333333334724.0DomainABC transmembrane type-1
TgeneABCB9chr12:122734417chr12:123435112ENST00000392439112188_471200.33333333333334767.0DomainABC transmembrane type-1
TgeneABCB9chr12:122734417chr12:123435112ENST00000442833112188_471200.33333333333334684.0DomainABC transmembrane type-1
TgeneABCB9chr12:122734417chr12:123435112ENST00000540285111188_471200.33333333333334704.0DomainABC transmembrane type-1
TgeneABCB9chr12:122734417chr12:123435112ENST00000542678112188_471200.33333333333334767.0DomainABC transmembrane type-1
TgeneABCB9chr12:122734418chr12:123435112ENST00000280560112188_471200.33333333333334767.0DomainABC transmembrane type-1
TgeneABCB9chr12:122734418chr12:123435112ENST00000344275112188_471200.33333333333334682.0DomainABC transmembrane type-1
TgeneABCB9chr12:122734418chr12:123435112ENST00000346530111188_471200.33333333333334724.0DomainABC transmembrane type-1
TgeneABCB9chr12:122734418chr12:123435112ENST00000392439112188_471200.33333333333334767.0DomainABC transmembrane type-1
TgeneABCB9chr12:122734418chr12:123435112ENST00000442833112188_471200.33333333333334684.0DomainABC transmembrane type-1
TgeneABCB9chr12:122734418chr12:123435112ENST00000540285111188_471200.33333333333334704.0DomainABC transmembrane type-1
TgeneABCB9chr12:122734418chr12:123435112ENST00000542678112188_471200.33333333333334767.0DomainABC transmembrane type-1
TgeneABCB9chr12:122734417chr12:123435112ENST00000280560112116_136200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000280560112185_205200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST0000028056011247_67200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST000002805601127_27200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST0000028056011284_104200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000344275112116_136200.33333333333334682.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000344275112185_205200.33333333333334682.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST0000034427511247_67200.33333333333334682.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST000003442751127_27200.33333333333334682.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST0000034427511284_104200.33333333333334682.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000346530111116_136200.33333333333334724.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000346530111185_205200.33333333333334724.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST0000034653011147_67200.33333333333334724.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST000003465301117_27200.33333333333334724.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST0000034653011184_104200.33333333333334724.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000392439112116_136200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000392439112185_205200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST0000039243911247_67200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST000003924391127_27200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST0000039243911284_104200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000442833112116_136200.33333333333334684.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000442833112185_205200.33333333333334684.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST0000044283311247_67200.33333333333334684.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST000004428331127_27200.33333333333334684.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST0000044283311284_104200.33333333333334684.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000540285111116_136200.33333333333334704.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000540285111185_205200.33333333333334704.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST0000054028511147_67200.33333333333334704.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST000005402851117_27200.33333333333334704.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST0000054028511184_104200.33333333333334704.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000542678112116_136200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST00000542678112185_205200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST0000054267811247_67200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST000005426781127_27200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734417chr12:123435112ENST0000054267811284_104200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000280560112116_136200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000280560112185_205200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST0000028056011247_67200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST000002805601127_27200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST0000028056011284_104200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000344275112116_136200.33333333333334682.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000344275112185_205200.33333333333334682.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST0000034427511247_67200.33333333333334682.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST000003442751127_27200.33333333333334682.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST0000034427511284_104200.33333333333334682.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000346530111116_136200.33333333333334724.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000346530111185_205200.33333333333334724.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST0000034653011147_67200.33333333333334724.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST000003465301117_27200.33333333333334724.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST0000034653011184_104200.33333333333334724.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000392439112116_136200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000392439112185_205200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST0000039243911247_67200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST000003924391127_27200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST0000039243911284_104200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000442833112116_136200.33333333333334684.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000442833112185_205200.33333333333334684.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST0000044283311247_67200.33333333333334684.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST000004428331127_27200.33333333333334684.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST0000044283311284_104200.33333333333334684.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000540285111116_136200.33333333333334704.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000540285111185_205200.33333333333334704.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST0000054028511147_67200.33333333333334704.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST000005402851117_27200.33333333333334704.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST0000054028511184_104200.33333333333334704.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000542678112116_136200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST00000542678112185_205200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST0000054267811247_67200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST000005426781127_27200.33333333333334767.0TransmembraneHelical
TgeneABCB9chr12:122734418chr12:123435112ENST0000054267811284_104200.33333333333334767.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
VPS33A
ABCB9


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to VPS33A-ABCB9


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to VPS33A-ABCB9


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource