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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:VTI1A-C10orf90

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: VTI1A-C10orf90
	FusionPDB ID: 98583
	FusionGDB2.0 ID: 98583
		Hgene	Tgene
	Gene symbol	VTI1A	C10orf90
	Gene ID	143187	118611
	Gene name	vesicle transport through interaction with t-SNAREs 1A	chromosome 10 open reading frame 90
	Synonyms	MMDS3\|MVti1\|VTI1RP2\|Vti1-rp2	FATS\|bA422P15.2
	Cytomap	10q25.2	10q26.2
	Type of gene	protein-coding	protein-coding
	Description	vesicle transport through interaction with t-SNAREs homolog 1ASNARE Vti1a-beta proteinvesicle transport v-SNARE protein Vti1-like 2	(E2-independent) E3 ubiquitin-conjugating enzyme FATSE2/E3 hybrid ubiquitin-protein ligase FATScentrosomal protein C10orf90fragile-site associated tumor suppressor homolog
	Modification date	20200313	20200313
	UniProtAcc	Q96AJ9	Q96M02
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000393077, ENST00000432306, ENST00000483122,	ENST00000356858, ENST00000368674, ENST00000392694, ENST00000480379, ENST00000284694, ENST00000454341, ENST00000544758,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	15 X 12 X 12=2160	3 X 2 X 2=12
	# samples	24	3
	** MAII score	log2(24/2160*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: VTI1A [Title/Abstract] AND C10orf90 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	VTI1A(114298089)-C10orf90(128202508), # samples:3
Anticipated loss of major functional domain due to fusion event.	VTI1A-C10orf90 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. VTI1A-C10orf90 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	VTI1A	GO:0042147	retrograde transport, endosome to Golgi	15215310\|18195106

Fusion gene breakpoints across VTI1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C10orf90 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-97-7554-01A	VTI1A	chr10	114298089	-	C10orf90	chr10	128202508	-
ChimerDB4	LUAD	TCGA-97-7554-01A	VTI1A	chr10	114298089	+	C10orf90	chr10	128202508	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000432306	VTI1A	chr10	114298089	+	ENST00000454341	C10orf90	chr10	128202508	-	3185	543	86	2329	747
ENST00000432306	VTI1A	chr10	114298089	+	ENST00000284694	C10orf90	chr10	128202508	-	3476	543	86	2620	844
ENST00000432306	VTI1A	chr10	114298089	+	ENST00000544758	C10orf90	chr10	128202508	-	2920	543	86	2620	844
ENST00000393077	VTI1A	chr10	114298089	+	ENST00000454341	C10orf90	chr10	128202508	-	3185	543	86	2329	747
ENST00000393077	VTI1A	chr10	114298089	+	ENST00000284694	C10orf90	chr10	128202508	-	3476	543	86	2620	844
ENST00000393077	VTI1A	chr10	114298089	+	ENST00000544758	C10orf90	chr10	128202508	-	2920	543	86	2620	844

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000432306	ENST00000454341	VTI1A	chr10	114298089	+	C10orf90	chr10	128202508	-	0.000986242	0.9990138
ENST00000432306	ENST00000284694	VTI1A	chr10	114298089	+	C10orf90	chr10	128202508	-	0.000697522	0.9993025
ENST00000432306	ENST00000544758	VTI1A	chr10	114298089	+	C10orf90	chr10	128202508	-	0.000955803	0.9990441
ENST00000393077	ENST00000454341	VTI1A	chr10	114298089	+	C10orf90	chr10	128202508	-	0.000986242	0.9990138
ENST00000393077	ENST00000284694	VTI1A	chr10	114298089	+	C10orf90	chr10	128202508	-	0.000697522	0.9993025
ENST00000393077	ENST00000544758	VTI1A	chr10	114298089	+	C10orf90	chr10	128202508	-	0.000955803	0.9990441

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>98583_98583_1_VTI1A-C10orf90_VTI1A_chr10_114298089_ENST00000393077_C10orf90_chr10_128202508_ENST00000284694_length(amino acids)=844AA_BP=152
MAWATRSGAAMSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEAKELLEQMDLEVREIPPQSRGMYSNRMRSYKQE
MGKLETDFKRSRIAYSDEVRNELLGDDGNSSENQRAHLLDNTERLERSSRRLEAGYQIAVETGLRDSYHSRRDQIALKNLQSDVTEAKSD
FTKETLASQNTKMISSIVISQMIDENKSRENRASLPLPCAIAQSRAHHAKQSLANRSGVNIHRAFALLPGRLGIPAPSDERGPEAELPPK
EERPCGGPRRGFASITITARRVGPPARALVWGTAGDSLCPKCRAEDTLFQAPPALANGAHPGRHQRSFACTEFSRNSSVVRLKVPEAHTG
LCERRKYWVTHADDKETSFSPDTPLSGKSPLVFSSCVHLRVSQQCPDSIYYVDKSLSVPIEPPQIASPKMHRSVLSLNLNCSSHRLTADG
VDGLVNREPISEALKQELLEGDQDLVGQRWNPGLQESHLKETPSLRRVHLGTGACPWSGSFPLENTELANVGANQVTVRKGEKDHTTHCH
ASDHANQLSIHIPGWSYRAVHTKVFSGSSKRQQGEVCMTVSAPPVEQKPTRHFLPIGDSSPSDDCLSRDLSEPTERRHQSFLKPRILFPG
FLCPLQDVCASLQEDNGVQIESKFPKGDYTCCDLVVKIKECKKSEDPTTPEPSPAAPSPAPRDGAGSPGLSEDCSESQQTPARSLTLQEA
LEVRKPQFISRSQERLKKLEHMVQQRKAQRKEDLRQKQSLLPIRTSKKQFTIPHPLSDNLFKPKERCISEKEMHMRSKRIYDNLPEVKKK

--------------------------------------------------------------

>98583_98583_2_VTI1A-C10orf90_VTI1A_chr10_114298089_ENST00000393077_C10orf90_chr10_128202508_ENST00000454341_length(amino acids)=747AA_BP=152
MAWATRSGAAMSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEAKELLEQMDLEVREIPPQSRGMYSNRMRSYKQE
MGKLETDFKRSRIAYSDEVRNELLGDDGNSSENQRAHLLDNTERLERSSRRLEAGYQIAVETGLRDSYHSRRDQIALKNLQSDVTEAKSD
FTKETLASQNTKMISSIVISQMIDENKSRENRASLPLPCAIAQSRAHHAKQSLANRSGVNIHRAFALLPGRLGIPAPSDERGPEAELPPK
EERPCGGPRRGFASITITARRVGPPARALVWGTAGDSLCPKCRAEDTLFQAPPALANGAHPGRHQRSFACTEFSRNSSVVRLKVPEAHTG
LCERRKYWVTHADDKETSFSPDTPLSGKSPLVFSSCVHLRVSQQCPDSIYYVDKSLSVPIEPPQIASPKMHRSVLSLNLNCSSHRLTADG
VDGLVNREPISEALKQELLEGDQDLVGQRWNPGLQESHLKETPSLRRVHLGTGACPWSGSFPLENTELANVGANQVTVRKGEKDHTTHCH
ASDHANQLSIHIPGWSYRAGDYTCCDLVVKIKECKKSEDPTTPEPSPAAPSPAPRDGAGSPGLSEDCSESQQTPARSLTLQEALEVRKPQ
FISRSQERLKKLEHMVQQRKAQRKEDLRQKQSLLPIRTSKKQFTIPHPLSDNLFKPKERCISEKEMHMRSKRIYDNLPEVKKKKEEQRKR

--------------------------------------------------------------

>98583_98583_3_VTI1A-C10orf90_VTI1A_chr10_114298089_ENST00000393077_C10orf90_chr10_128202508_ENST00000544758_length(amino acids)=844AA_BP=152
MAWATRSGAAMSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEAKELLEQMDLEVREIPPQSRGMYSNRMRSYKQE
MGKLETDFKRSRIAYSDEVRNELLGDDGNSSENQRAHLLDNTERLERSSRRLEAGYQIAVETGLRDSYHSRRDQIALKNLQSDVTEAKSD
FTKETLASQNTKMISSIVISQMIDENKSRENRASLPLPCAIAQSRAHHAKQSLANRSGVNIHRAFALLPGRLGIPAPSDERGPEAELPPK
EERPCGGPRRGFASITITARRVGPPARALVWGTAGDSLCPKCRAEDTLFQAPPALANGAHPGRHQRSFACTEFSRNSSVVRLKVPEAHTG
LCERRKYWVTHADDKETSFSPDTPLSGKSPLVFSSCVHLRVSQQCPDSIYYVDKSLSVPIEPPQIASPKMHRSVLSLNLNCSSHRLTADG
VDGLVNREPISEALKQELLEGDQDLVGQRWNPGLQESHLKETPSLRRVHLGTGACPWSGSFPLENTELANVGANQVTVRKGEKDHTTHCH
ASDHANQLSIHIPGWSYRAVHTKVFSGSSKRQQGEVCMTVSAPPVEQKPTRHFLPIGDSSPSDDCLSRDLSEPTERRHQSFLKPRILFPG
FLCPLQDVCASLQEDNGVQIESKFPKGDYTCCDLVVKIKECKKSEDPTTPEPSPAAPSPAPRDGAGSPGLSEDCSESQQTPARSLTLQEA
LEVRKPQFISRSQERLKKLEHMVQQRKAQRKEDLRQKQSLLPIRTSKKQFTIPHPLSDNLFKPKERCISEKEMHMRSKRIYDNLPEVKKK

--------------------------------------------------------------

>98583_98583_4_VTI1A-C10orf90_VTI1A_chr10_114298089_ENST00000432306_C10orf90_chr10_128202508_ENST00000284694_length(amino acids)=844AA_BP=152
MAWATRSGAAMSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEAKELLEQMDLEVREIPPQSRGMYSNRMRSYKQE
MGKLETDFKRSRIAYSDEVRNELLGDDGNSSENQRAHLLDNTERLERSSRRLEAGYQIAVETGLRDSYHSRRDQIALKNLQSDVTEAKSD
FTKETLASQNTKMISSIVISQMIDENKSRENRASLPLPCAIAQSRAHHAKQSLANRSGVNIHRAFALLPGRLGIPAPSDERGPEAELPPK
EERPCGGPRRGFASITITARRVGPPARALVWGTAGDSLCPKCRAEDTLFQAPPALANGAHPGRHQRSFACTEFSRNSSVVRLKVPEAHTG
LCERRKYWVTHADDKETSFSPDTPLSGKSPLVFSSCVHLRVSQQCPDSIYYVDKSLSVPIEPPQIASPKMHRSVLSLNLNCSSHRLTADG
VDGLVNREPISEALKQELLEGDQDLVGQRWNPGLQESHLKETPSLRRVHLGTGACPWSGSFPLENTELANVGANQVTVRKGEKDHTTHCH
ASDHANQLSIHIPGWSYRAVHTKVFSGSSKRQQGEVCMTVSAPPVEQKPTRHFLPIGDSSPSDDCLSRDLSEPTERRHQSFLKPRILFPG
FLCPLQDVCASLQEDNGVQIESKFPKGDYTCCDLVVKIKECKKSEDPTTPEPSPAAPSPAPRDGAGSPGLSEDCSESQQTPARSLTLQEA
LEVRKPQFISRSQERLKKLEHMVQQRKAQRKEDLRQKQSLLPIRTSKKQFTIPHPLSDNLFKPKERCISEKEMHMRSKRIYDNLPEVKKK

--------------------------------------------------------------

>98583_98583_5_VTI1A-C10orf90_VTI1A_chr10_114298089_ENST00000432306_C10orf90_chr10_128202508_ENST00000454341_length(amino acids)=747AA_BP=152
MAWATRSGAAMSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEAKELLEQMDLEVREIPPQSRGMYSNRMRSYKQE
MGKLETDFKRSRIAYSDEVRNELLGDDGNSSENQRAHLLDNTERLERSSRRLEAGYQIAVETGLRDSYHSRRDQIALKNLQSDVTEAKSD
FTKETLASQNTKMISSIVISQMIDENKSRENRASLPLPCAIAQSRAHHAKQSLANRSGVNIHRAFALLPGRLGIPAPSDERGPEAELPPK
EERPCGGPRRGFASITITARRVGPPARALVWGTAGDSLCPKCRAEDTLFQAPPALANGAHPGRHQRSFACTEFSRNSSVVRLKVPEAHTG
LCERRKYWVTHADDKETSFSPDTPLSGKSPLVFSSCVHLRVSQQCPDSIYYVDKSLSVPIEPPQIASPKMHRSVLSLNLNCSSHRLTADG
VDGLVNREPISEALKQELLEGDQDLVGQRWNPGLQESHLKETPSLRRVHLGTGACPWSGSFPLENTELANVGANQVTVRKGEKDHTTHCH
ASDHANQLSIHIPGWSYRAGDYTCCDLVVKIKECKKSEDPTTPEPSPAAPSPAPRDGAGSPGLSEDCSESQQTPARSLTLQEALEVRKPQ
FISRSQERLKKLEHMVQQRKAQRKEDLRQKQSLLPIRTSKKQFTIPHPLSDNLFKPKERCISEKEMHMRSKRIYDNLPEVKKKKEEQRKR

--------------------------------------------------------------

>98583_98583_6_VTI1A-C10orf90_VTI1A_chr10_114298089_ENST00000432306_C10orf90_chr10_128202508_ENST00000544758_length(amino acids)=844AA_BP=152
MAWATRSGAAMSSDFEGYEQDFAVLTAEITSKIARVPRLPPDEKKQMVANVEKQLEEAKELLEQMDLEVREIPPQSRGMYSNRMRSYKQE
MGKLETDFKRSRIAYSDEVRNELLGDDGNSSENQRAHLLDNTERLERSSRRLEAGYQIAVETGLRDSYHSRRDQIALKNLQSDVTEAKSD
FTKETLASQNTKMISSIVISQMIDENKSRENRASLPLPCAIAQSRAHHAKQSLANRSGVNIHRAFALLPGRLGIPAPSDERGPEAELPPK
EERPCGGPRRGFASITITARRVGPPARALVWGTAGDSLCPKCRAEDTLFQAPPALANGAHPGRHQRSFACTEFSRNSSVVRLKVPEAHTG
LCERRKYWVTHADDKETSFSPDTPLSGKSPLVFSSCVHLRVSQQCPDSIYYVDKSLSVPIEPPQIASPKMHRSVLSLNLNCSSHRLTADG
VDGLVNREPISEALKQELLEGDQDLVGQRWNPGLQESHLKETPSLRRVHLGTGACPWSGSFPLENTELANVGANQVTVRKGEKDHTTHCH
ASDHANQLSIHIPGWSYRAVHTKVFSGSSKRQQGEVCMTVSAPPVEQKPTRHFLPIGDSSPSDDCLSRDLSEPTERRHQSFLKPRILFPG
FLCPLQDVCASLQEDNGVQIESKFPKGDYTCCDLVVKIKECKKSEDPTTPEPSPAAPSPAPRDGAGSPGLSEDCSESQQTPARSLTLQEA
LEVRKPQFISRSQERLKKLEHMVQQRKAQRKEDLRQKQSLLPIRTSKKQFTIPHPLSDNLFKPKERCISEKEMHMRSKRIYDNLPEVKKK

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:114298089/chr10:128202508)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
VTI1A Q96AJ9	C10orf90 Q96M02
FUNCTION: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. {ECO:0000269\|PubMed:18195106, ECO:0000269\|PubMed:19138172}.	FUNCTION: Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (By similarity). May have a role in the assembly of primary cilia (Probable). {ECO:0000250\|UniProtKB:D2J0Y4, ECO:0000305\|PubMed:20844083}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

VTI1A

chr10:114298089

chr10:128202508

ENST00000393077

31_92

142.33333333333334

218.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

VTI1A

chr10:114298089

chr10:128202508

ENST00000432306

31_92

142.33333333333334

204.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

C10orf90

chr10:114298089

chr10:128202508

ENST00000284694

663_666

7.333333333333333

700.0

Compositional bias

Note=Poly-Lys

Tgene

C10orf90

chr10:114298089

chr10:128202508

ENST00000454341

663_666

7.333333333333333

603.0

Compositional bias

Note=Poly-Lys

Tgene

C10orf90

chr10:114298089

chr10:128202508

ENST00000480379

663_666

104.0

Compositional bias

Note=Poly-Lys

Tgene

C10orf90

chr10:114298089

chr10:128202508

ENST00000284694

571_699

7.333333333333333

700.0

Region

ALMS motif

Tgene

C10orf90

chr10:114298089

chr10:128202508

ENST00000454341

571_699

7.333333333333333

603.0

Region

ALMS motif

Tgene

C10orf90

chr10:114298089

chr10:128202508

ENST00000480379

571_699

104.0

Region

ALMS motif

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

VTI1A

chr10:114298089

chr10:128202508

ENST00000393077

112_178

142.33333333333334

218.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

VTI1A

chr10:114298089

chr10:128202508

ENST00000432306

112_178

142.33333333333334

204.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

VTI1A

chr10:114298089

chr10:128202508

ENST00000393077

1_192

142.33333333333334

218.0

Topological domain

Cytoplasmic

Hgene

VTI1A

chr10:114298089

chr10:128202508

ENST00000393077

214_217

142.33333333333334

218.0

Topological domain

Extracellular

Hgene

VTI1A

chr10:114298089

chr10:128202508

ENST00000432306

1_192

142.33333333333334

204.0

Topological domain

Cytoplasmic

Hgene

VTI1A

chr10:114298089

chr10:128202508

ENST00000432306

214_217

142.33333333333334

204.0

Topological domain

Extracellular

Hgene

VTI1A

chr10:114298089

chr10:128202508

ENST00000393077

193_213

142.33333333333334

218.0

Transmembrane

Helical

Hgene

VTI1A

chr10:114298089

chr10:128202508

ENST00000432306

193_213

142.33333333333334

204.0

Transmembrane

Helical

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
VTI1A	VAMP4, VAMP3, STX7, STX8, VAMP8, env, TMBIM6, STX6, STX12, CLEC12A, Snap29, HAUS1, HNRNPL, RNF4, BET1, APEX1, NAPA, VAMP5, ORF7b, ARF6, B3GAT1, LAMP2, LAMP3, LAMTOR1, MARCKS, RAB2A, RAB4A, RAB5A, RAB5C, RAB9A, EDEM1, TRPC4AP, TMEM74, ZDHHC12, SEC22B, SMPD1, TMEM9, NAPG, TMEM9B, GPRC5B, B4GALT5, TMEM171, ASPH, SLC39A4, VPS45, SNAP29, HLA-C, STX11, STX18,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
VTI1A
C10orf90

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to VTI1A-C10orf90

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to VTI1A-C10orf90

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	VTI1A	C0001418	Adenocarcinoma	1	CTD_human
Hgene	VTI1A	C0009402	Colorectal Carcinoma	1	CTD_human
Hgene	VTI1A	C0009404	Colorectal Neoplasms	1	CTD_human
Hgene	VTI1A	C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
Hgene	VTI1A	C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
Hgene	VTI1A	C0205643	Carcinoma, Cribriform	1	CTD_human
Hgene	VTI1A	C0205644	Carcinoma, Granular Cell	1	CTD_human
Hgene	VTI1A	C0205645	Adenocarcinoma, Tubular	1	CTD_human