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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:WDR36-NREP

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: WDR36-NREP
	FusionPDB ID: 98958
	FusionGDB2.0 ID: 98958
		Hgene	Tgene
	Gene symbol	WDR36	NREP
	Gene ID	134430	9315
	Gene name	WD repeat domain 36	neuronal regeneration related protein
	Synonyms	GLC1G\|TA-WDRP\|TAWDRP\|UTP21	C5orf13\|D4S114\|P311\|PRO1873\|PTZ17\|SEZ17
	Cytomap	5q22.1	5q22.1
	Type of gene	protein-coding	protein-coding
	Description	WD repeat-containing protein 36T-cell activation WD repeat proteinT-cell activation WD repeat-containing protein	neuronal regeneration-related proteinneuronal protein 3.1neuronal regeneration related protein homologprotein p311
	Modification date	20200313	20200313
	UniProtAcc	.	Q16612
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000505303, ENST00000506538, ENST00000513710,	ENST00000419114, ENST00000453526, ENST00000455559, ENST00000507742, ENST00000508870, ENST00000509427, ENST00000509979, ENST00000257435, ENST00000379671, ENST00000395634, ENST00000446294, ENST00000447165, ENST00000450761, ENST00000509025, ENST00000515855,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	2 X 2 X 1=4	9 X 8 X 5=360
	# samples	2	10
	** MAII score	log2(2/4*10)=2.32192809488736	log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: WDR36 [Title/Abstract] AND NREP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	WDR36(110428316)-NREP(111071204), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across WDR36 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NREP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-BA-4077-01B	WDR36	chr5	110428316	+	NREP	chr5	111071204	-
ChimerDB4	HNSC	TCGA-BA-4077	WDR36	chr5	110428316	+	NREP	chr5	111071204	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000506538	WDR36	chr5	110428316	+	ENST00000395634	NREP	chr5	111071204	-	2044	903	573	1106	177
ENST00000506538	WDR36	chr5	110428316	+	ENST00000450761	NREP	chr5	111071204	-	1337	903	573	1106	177
ENST00000506538	WDR36	chr5	110428316	+	ENST00000509025	NREP	chr5	111071204	-	1770	903	573	1013	146
ENST00000506538	WDR36	chr5	110428316	+	ENST00000379671	NREP	chr5	111071204	-	3216	903	573	1106	177
ENST00000506538	WDR36	chr5	110428316	+	ENST00000257435	NREP	chr5	111071204	-	2732	903	573	1106	177
ENST00000506538	WDR36	chr5	110428316	+	ENST00000447165	NREP	chr5	111071204	-	2725	903	573	1106	177
ENST00000506538	WDR36	chr5	110428316	+	ENST00000446294	NREP	chr5	111071204	-	2712	903	573	1106	177
ENST00000506538	WDR36	chr5	110428316	+	ENST00000515855	NREP	chr5	111071204	-	1584	903	573	1007	144
ENST00000513710	WDR36	chr5	110428316	+	ENST00000395634	NREP	chr5	111071204	-	1475	334	4	537	177
ENST00000513710	WDR36	chr5	110428316	+	ENST00000450761	NREP	chr5	111071204	-	768	334	4	537	177
ENST00000513710	WDR36	chr5	110428316	+	ENST00000509025	NREP	chr5	111071204	-	1201	334	4	444	146
ENST00000513710	WDR36	chr5	110428316	+	ENST00000379671	NREP	chr5	111071204	-	2647	334	4	537	177
ENST00000513710	WDR36	chr5	110428316	+	ENST00000257435	NREP	chr5	111071204	-	2163	334	4	537	177
ENST00000513710	WDR36	chr5	110428316	+	ENST00000447165	NREP	chr5	111071204	-	2156	334	4	537	177
ENST00000513710	WDR36	chr5	110428316	+	ENST00000446294	NREP	chr5	111071204	-	2143	334	4	537	177
ENST00000513710	WDR36	chr5	110428316	+	ENST00000515855	NREP	chr5	111071204	-	1015	334	4	438	144
ENST00000505303	WDR36	chr5	110428316	+	ENST00000395634	NREP	chr5	111071204	-	1439	298	28	501	157
ENST00000505303	WDR36	chr5	110428316	+	ENST00000450761	NREP	chr5	111071204	-	732	298	28	501	157
ENST00000505303	WDR36	chr5	110428316	+	ENST00000509025	NREP	chr5	111071204	-	1165	298	28	408	126
ENST00000505303	WDR36	chr5	110428316	+	ENST00000379671	NREP	chr5	111071204	-	2611	298	28	501	157
ENST00000505303	WDR36	chr5	110428316	+	ENST00000257435	NREP	chr5	111071204	-	2127	298	28	501	157
ENST00000505303	WDR36	chr5	110428316	+	ENST00000447165	NREP	chr5	111071204	-	2120	298	28	501	157
ENST00000505303	WDR36	chr5	110428316	+	ENST00000446294	NREP	chr5	111071204	-	2107	298	28	501	157
ENST00000505303	WDR36	chr5	110428316	+	ENST00000515855	NREP	chr5	111071204	-	979	298	28	402	124

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000506538	ENST00000395634	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.08378703	0.916213
ENST00000506538	ENST00000450761	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.078125834	0.92187417
ENST00000506538	ENST00000509025	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.32668698	0.673313
ENST00000506538	ENST00000379671	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.0697795	0.9302204
ENST00000506538	ENST00000257435	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.0862102	0.9137898
ENST00000506538	ENST00000447165	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.08839169	0.91160834
ENST00000506538	ENST00000446294	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.085155375	0.9148446
ENST00000506538	ENST00000515855	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.30811408	0.69188595
ENST00000513710	ENST00000395634	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.037431818	0.9625681
ENST00000513710	ENST00000450761	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.04913646	0.9508636
ENST00000513710	ENST00000509025	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.10920018	0.8907999
ENST00000513710	ENST00000379671	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.064437136	0.9355628
ENST00000513710	ENST00000257435	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.03790001	0.9621
ENST00000513710	ENST00000447165	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.0377201	0.9622799
ENST00000513710	ENST00000446294	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.035150077	0.96484995
ENST00000513710	ENST00000515855	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.25022006	0.7497799
ENST00000505303	ENST00000395634	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.030188218	0.9698118
ENST00000505303	ENST00000450761	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.029020507	0.97097945
ENST00000505303	ENST00000509025	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.083243676	0.9167563
ENST00000505303	ENST00000379671	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.08582283	0.91417724
ENST00000505303	ENST00000257435	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.0521364	0.9478636
ENST00000505303	ENST00000447165	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.04614876	0.95385116
ENST00000505303	ENST00000446294	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.041285582	0.95871437
ENST00000505303	ENST00000515855	WDR36	chr5	110428316	+	NREP	chr5	111071204	-	0.27325544	0.7267446

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>98958_98958_1_WDR36-NREP_WDR36_chr5_110428316_ENST00000505303_NREP_chr5_111071204_ENST00000257435_length(amino acids)=157AA_BP=90
MCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFSALKRRFYVTTCVGKSFHTYD

--------------------------------------------------------------

>98958_98958_2_WDR36-NREP_WDR36_chr5_110428316_ENST00000505303_NREP_chr5_111071204_ENST00000379671_length(amino acids)=157AA_BP=90
MCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFSALKRRFYVTTCVGKSFHTYD

--------------------------------------------------------------

>98958_98958_3_WDR36-NREP_WDR36_chr5_110428316_ENST00000505303_NREP_chr5_111071204_ENST00000395634_length(amino acids)=157AA_BP=90
MCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFSALKRRFYVTTCVGKSFHTYD

--------------------------------------------------------------

>98958_98958_4_WDR36-NREP_WDR36_chr5_110428316_ENST00000505303_NREP_chr5_111071204_ENST00000446294_length(amino acids)=157AA_BP=90
MCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFSALKRRFYVTTCVGKSFHTYD

--------------------------------------------------------------

>98958_98958_5_WDR36-NREP_WDR36_chr5_110428316_ENST00000505303_NREP_chr5_111071204_ENST00000447165_length(amino acids)=157AA_BP=90
MCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFSALKRRFYVTTCVGKSFHTYD

--------------------------------------------------------------

>98958_98958_6_WDR36-NREP_WDR36_chr5_110428316_ENST00000505303_NREP_chr5_111071204_ENST00000450761_length(amino acids)=157AA_BP=90
MCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFSALKRRFYVTTCVGKSFHTYD

--------------------------------------------------------------

>98958_98958_7_WDR36-NREP_WDR36_chr5_110428316_ENST00000505303_NREP_chr5_111071204_ENST00000509025_length(amino acids)=126AA_BP=90
MCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFSALKRRFYVTTCVGKSFHTYD

--------------------------------------------------------------

>98958_98958_8_WDR36-NREP_WDR36_chr5_110428316_ENST00000505303_NREP_chr5_111071204_ENST00000515855_length(amino acids)=124AA_BP=90
MCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFSALKRRFYVTTCVGKSFHTYD

--------------------------------------------------------------

>98958_98958_9_WDR36-NREP_WDR36_chr5_110428316_ENST00000506538_NREP_chr5_111071204_ENST00000257435_length(amino acids)=177AA_BP=110
MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFS

--------------------------------------------------------------

>98958_98958_10_WDR36-NREP_WDR36_chr5_110428316_ENST00000506538_NREP_chr5_111071204_ENST00000379671_length(amino acids)=177AA_BP=110
MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFS

--------------------------------------------------------------

>98958_98958_11_WDR36-NREP_WDR36_chr5_110428316_ENST00000506538_NREP_chr5_111071204_ENST00000395634_length(amino acids)=177AA_BP=110
MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFS

--------------------------------------------------------------

>98958_98958_12_WDR36-NREP_WDR36_chr5_110428316_ENST00000506538_NREP_chr5_111071204_ENST00000446294_length(amino acids)=177AA_BP=110
MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFS

--------------------------------------------------------------

>98958_98958_13_WDR36-NREP_WDR36_chr5_110428316_ENST00000506538_NREP_chr5_111071204_ENST00000447165_length(amino acids)=177AA_BP=110
MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFS

--------------------------------------------------------------

>98958_98958_14_WDR36-NREP_WDR36_chr5_110428316_ENST00000506538_NREP_chr5_111071204_ENST00000450761_length(amino acids)=177AA_BP=110
MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFS

--------------------------------------------------------------

>98958_98958_15_WDR36-NREP_WDR36_chr5_110428316_ENST00000506538_NREP_chr5_111071204_ENST00000509025_length(amino acids)=146AA_BP=110
MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFS

--------------------------------------------------------------

>98958_98958_16_WDR36-NREP_WDR36_chr5_110428316_ENST00000506538_NREP_chr5_111071204_ENST00000515855_length(amino acids)=144AA_BP=110
MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFS

--------------------------------------------------------------

>98958_98958_17_WDR36-NREP_WDR36_chr5_110428316_ENST00000513710_NREP_chr5_111071204_ENST00000257435_length(amino acids)=177AA_BP=110
MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFS

--------------------------------------------------------------

>98958_98958_18_WDR36-NREP_WDR36_chr5_110428316_ENST00000513710_NREP_chr5_111071204_ENST00000379671_length(amino acids)=177AA_BP=110
MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFS

--------------------------------------------------------------

>98958_98958_19_WDR36-NREP_WDR36_chr5_110428316_ENST00000513710_NREP_chr5_111071204_ENST00000395634_length(amino acids)=177AA_BP=110
MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFS

--------------------------------------------------------------

>98958_98958_20_WDR36-NREP_WDR36_chr5_110428316_ENST00000513710_NREP_chr5_111071204_ENST00000446294_length(amino acids)=177AA_BP=110
MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFS

--------------------------------------------------------------

>98958_98958_21_WDR36-NREP_WDR36_chr5_110428316_ENST00000513710_NREP_chr5_111071204_ENST00000447165_length(amino acids)=177AA_BP=110
MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFS

--------------------------------------------------------------

>98958_98958_22_WDR36-NREP_WDR36_chr5_110428316_ENST00000513710_NREP_chr5_111071204_ENST00000450761_length(amino acids)=177AA_BP=110
MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFS

--------------------------------------------------------------

>98958_98958_23_WDR36-NREP_WDR36_chr5_110428316_ENST00000513710_NREP_chr5_111071204_ENST00000509025_length(amino acids)=146AA_BP=110
MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFS

--------------------------------------------------------------

>98958_98958_24_WDR36-NREP_WDR36_chr5_110428316_ENST00000513710_NREP_chr5_111071204_ENST00000515855_length(amino acids)=144AA_BP=110
MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:110428316/chr5:111071204)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NREP Q16612
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation. {ECO:0000250, ECO:0000269\|PubMed:11358844, ECO:0000269\|PubMed:16229809}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000506538

128_157

110.0

952.0

Repeat

Note=WD 2

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000506538

166_199

110.0

952.0

Repeat

Note=WD 3

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000506538

208_242

110.0

952.0

Repeat

Note=WD 4

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000506538

249_286

110.0

952.0

Repeat

Note=WD 5

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000506538

293_328

110.0

952.0

Repeat

Note=WD 6

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000506538

333_376

110.0

952.0

Repeat

Note=WD 7

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000506538

383_417

110.0

952.0

Repeat

Note=WD 8

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000506538

445_484

110.0

952.0

Repeat

Note=WD 9

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000506538

497_531

110.0

952.0

Repeat

Note=WD 10

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000506538

542_578

110.0

952.0

Repeat

Note=WD 11

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000506538

583_618

110.0

952.0

Repeat

Note=WD 12

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000506538

620_661

110.0

952.0

Repeat

Note=WD 13

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000506538

663_701

110.0

952.0

Repeat

Note=WD 14

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000506538

86_119

110.0

952.0

Repeat

Note=WD 1

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000513710

128_157

110.0

952.0

Repeat

Note=WD 2

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000513710

166_199

110.0

952.0

Repeat

Note=WD 3

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000513710

208_242

110.0

952.0

Repeat

Note=WD 4

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000513710

249_286

110.0

952.0

Repeat

Note=WD 5

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000513710

293_328

110.0

952.0

Repeat

Note=WD 6

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000513710

333_376

110.0

952.0

Repeat

Note=WD 7

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000513710

383_417

110.0

952.0

Repeat

Note=WD 8

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000513710

445_484

110.0

952.0

Repeat

Note=WD 9

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000513710

497_531

110.0

952.0

Repeat

Note=WD 10

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000513710

542_578

110.0

952.0

Repeat

Note=WD 11

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000513710

583_618

110.0

952.0

Repeat

Note=WD 12

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000513710

620_661

110.0

952.0

Repeat

Note=WD 13

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000513710

663_701

110.0

952.0

Repeat

Note=WD 14

Hgene

WDR36

chr5:110428316

chr5:111071204

ENST00000513710

86_119

110.0

952.0

Repeat

Note=WD 1

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>193_WDR36_110428316_NREP_111071204_ranked_0.pdb	WDR36	110428316	110428316	ENST00000515855	NREP	chr5	111071204	-	MCCTEGSLRKRDSQRAPEAVLCLQLWQRTVPLDTLKGLGTCFPSGPELRGAGIAAAMERASERRTASALFAGFRALGLFSNDIPHVVRFS	177

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

WDR36_pLDDT.png

NREP_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
WDR36
NREP

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to WDR36-NREP

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to WDR36-NREP

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source