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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:WHSC1L1-RSF1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: WHSC1L1-RSF1
	FusionPDB ID: 99218
	FusionGDB2.0 ID: 99218
		Hgene	Tgene
	Gene symbol	WHSC1L1	RSF1
	Gene ID	54904	51773
	Gene name	nuclear receptor binding SET domain protein 3	remodeling and spacing factor 1
	Synonyms	KMT3F\|KMT3G\|WHISTLE\|WHSC1L1\|pp14328	HBXAP\|RSF-1\|XAP8\|p325
	Cytomap	8p11.23	11q14.1
	Type of gene	protein-coding	protein-coding
	Description	histone-lysine N-methyltransferase NSD3WHSC1-like 1 isoform 9 with methyltransferase activity to lysineWolf-Hirschhorn syndrome candidate 1-like 1nuclear SET domain-containing protein 3protein whistle	remodeling and spacing factor 1HBV pX-associated protein 8hepatitis B virus x-associated proteinp325 subunit of RSF chromatin-remodeling complex
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000316985, ENST00000317025, ENST00000433384, ENST00000527502, ENST00000525081,	ENST00000530604, ENST00000308488, ENST00000360355, ENST00000480887,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	31 X 27 X 13=10881	16 X 11 X 7=1232
	# samples	46	19
	** MAII score	log2(46/10881*10)=-4.56403347974706 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/1232*10)=-2.69693093236395 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: WHSC1L1 [Title/Abstract] AND RSF1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	WHSC1L1(38194823)-RSF1(77402283), # samples:1
Anticipated loss of major functional domain due to fusion event.	WHSC1L1-RSF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. WHSC1L1-RSF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. WHSC1L1-RSF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. WHSC1L1-RSF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	WHSC1L1	GO:0016571	histone methylation	16682010
Tgene	RSF1	GO:0006334	nucleosome assembly	12972596
Tgene	RSF1	GO:0006338	chromatin remodeling	9836642
Tgene	RSF1	GO:0006352	DNA-templated transcription, initiation	9836642
Tgene	RSF1	GO:0016584	nucleosome positioning	9836642
Tgene	RSF1	GO:0043392	negative regulation of DNA binding	12972596
Tgene	RSF1	GO:0045892	negative regulation of transcription, DNA-templated	11944984
Tgene	RSF1	GO:0045893	positive regulation of transcription, DNA-templated	11788598
Tgene	RSF1	GO:0050434	positive regulation of viral transcription	11788598

Fusion gene breakpoints across WHSC1L1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RSF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-B6-A0RL-01A	WHSC1L1	chr8	38194823	-	RSF1	chr11	77402283	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000317025	WHSC1L1	chr8	38194823	-	ENST00000308488	RSF1	chr11	77402283	-	9855	1428	1284	2933	549
ENST00000317025	WHSC1L1	chr8	38194823	-	ENST00000360355	RSF1	chr11	77402283	-	3621	1428	1284	2933	549
ENST00000317025	WHSC1L1	chr8	38194823	-	ENST00000480887	RSF1	chr11	77402283	-	3621	1428	1284	2933	549
ENST00000433384	WHSC1L1	chr8	38194823	-	ENST00000308488	RSF1	chr11	77402283	-	9828	1401	1257	2906	549
ENST00000433384	WHSC1L1	chr8	38194823	-	ENST00000360355	RSF1	chr11	77402283	-	3594	1401	1257	2906	549
ENST00000433384	WHSC1L1	chr8	38194823	-	ENST00000480887	RSF1	chr11	77402283	-	3594	1401	1257	2906	549
ENST00000527502	WHSC1L1	chr8	38194823	-	ENST00000308488	RSF1	chr11	77402283	-	9429	1002	858	2507	549
ENST00000527502	WHSC1L1	chr8	38194823	-	ENST00000360355	RSF1	chr11	77402283	-	3195	1002	858	2507	549
ENST00000527502	WHSC1L1	chr8	38194823	-	ENST00000480887	RSF1	chr11	77402283	-	3195	1002	858	2507	549
ENST00000316985	WHSC1L1	chr8	38194823	-	ENST00000308488	RSF1	chr11	77402283	-	9855	1428	1284	2933	549
ENST00000316985	WHSC1L1	chr8	38194823	-	ENST00000360355	RSF1	chr11	77402283	-	3621	1428	1284	2933	549
ENST00000316985	WHSC1L1	chr8	38194823	-	ENST00000480887	RSF1	chr11	77402283	-	3621	1428	1284	2933	549

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000317025	ENST00000308488	WHSC1L1	chr8	38194823	-	RSF1	chr11	77402283	-	0.000318815	0.99968123
ENST00000317025	ENST00000360355	WHSC1L1	chr8	38194823	-	RSF1	chr11	77402283	-	0.002500312	0.99749964
ENST00000317025	ENST00000480887	WHSC1L1	chr8	38194823	-	RSF1	chr11	77402283	-	0.002500312	0.99749964
ENST00000433384	ENST00000308488	WHSC1L1	chr8	38194823	-	RSF1	chr11	77402283	-	0.000320114	0.9996799
ENST00000433384	ENST00000360355	WHSC1L1	chr8	38194823	-	RSF1	chr11	77402283	-	0.002536846	0.9974631
ENST00000433384	ENST00000480887	WHSC1L1	chr8	38194823	-	RSF1	chr11	77402283	-	0.002536846	0.9974631
ENST00000527502	ENST00000308488	WHSC1L1	chr8	38194823	-	RSF1	chr11	77402283	-	0.000299875	0.9997002
ENST00000527502	ENST00000360355	WHSC1L1	chr8	38194823	-	RSF1	chr11	77402283	-	0.003388662	0.9966113
ENST00000527502	ENST00000480887	WHSC1L1	chr8	38194823	-	RSF1	chr11	77402283	-	0.003388662	0.9966113
ENST00000316985	ENST00000308488	WHSC1L1	chr8	38194823	-	RSF1	chr11	77402283	-	0.000318815	0.99968123
ENST00000316985	ENST00000360355	WHSC1L1	chr8	38194823	-	RSF1	chr11	77402283	-	0.002500312	0.99749964
ENST00000316985	ENST00000480887	WHSC1L1	chr8	38194823	-	RSF1	chr11	77402283	-	0.002500312	0.99749964

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>99218_99218_1_WHSC1L1-RSF1_WHSC1L1_chr8_38194823_ENST00000316985_RSF1_chr11_77402283_ENST00000308488_length(amino acids)=549AA_BP=48
MFQQRKCPLVLSFRLAILCGPRWEPILGGLVWFQVIPSLRFILKLTQEKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENII
PPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERK
ENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRL
RRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEES
YLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYR
IESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLV

--------------------------------------------------------------

>99218_99218_2_WHSC1L1-RSF1_WHSC1L1_chr8_38194823_ENST00000316985_RSF1_chr11_77402283_ENST00000360355_length(amino acids)=549AA_BP=48
MFQQRKCPLVLSFRLAILCGPRWEPILGGLVWFQVIPSLRFILKLTQEKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENII
PPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERK
ENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRL
RRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEES
YLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYR
IESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLV

--------------------------------------------------------------

>99218_99218_3_WHSC1L1-RSF1_WHSC1L1_chr8_38194823_ENST00000316985_RSF1_chr11_77402283_ENST00000480887_length(amino acids)=549AA_BP=48
MFQQRKCPLVLSFRLAILCGPRWEPILGGLVWFQVIPSLRFILKLTQEKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENII
PPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERK
ENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRL
RRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEES
YLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYR
IESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLV

--------------------------------------------------------------

>99218_99218_4_WHSC1L1-RSF1_WHSC1L1_chr8_38194823_ENST00000317025_RSF1_chr11_77402283_ENST00000308488_length(amino acids)=549AA_BP=48
MFQQRKCPLVLSFRLAILCGPRWEPILGGLVWFQVIPSLRFILKLTQEKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENII
PPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERK
ENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRL
RRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEES
YLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYR
IESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLV

--------------------------------------------------------------

>99218_99218_5_WHSC1L1-RSF1_WHSC1L1_chr8_38194823_ENST00000317025_RSF1_chr11_77402283_ENST00000360355_length(amino acids)=549AA_BP=48
MFQQRKCPLVLSFRLAILCGPRWEPILGGLVWFQVIPSLRFILKLTQEKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENII
PPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERK
ENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRL
RRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEES
YLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYR
IESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLV

--------------------------------------------------------------

>99218_99218_6_WHSC1L1-RSF1_WHSC1L1_chr8_38194823_ENST00000317025_RSF1_chr11_77402283_ENST00000480887_length(amino acids)=549AA_BP=48
MFQQRKCPLVLSFRLAILCGPRWEPILGGLVWFQVIPSLRFILKLTQEKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENII
PPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERK
ENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRL
RRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEES
YLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYR
IESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLV

--------------------------------------------------------------

>99218_99218_7_WHSC1L1-RSF1_WHSC1L1_chr8_38194823_ENST00000433384_RSF1_chr11_77402283_ENST00000308488_length(amino acids)=549AA_BP=48
MFQQRKCPLVLSFRLAILCGPRWEPILGGLVWFQVIPSLRFILKLTQEKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENII
PPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERK
ENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRL
RRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEES
YLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYR
IESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLV

--------------------------------------------------------------

>99218_99218_8_WHSC1L1-RSF1_WHSC1L1_chr8_38194823_ENST00000433384_RSF1_chr11_77402283_ENST00000360355_length(amino acids)=549AA_BP=48
MFQQRKCPLVLSFRLAILCGPRWEPILGGLVWFQVIPSLRFILKLTQEKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENII
PPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERK
ENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRL
RRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEES
YLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYR
IESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLV

--------------------------------------------------------------

>99218_99218_9_WHSC1L1-RSF1_WHSC1L1_chr8_38194823_ENST00000433384_RSF1_chr11_77402283_ENST00000480887_length(amino acids)=549AA_BP=48
MFQQRKCPLVLSFRLAILCGPRWEPILGGLVWFQVIPSLRFILKLTQEKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENII
PPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERK
ENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRL
RRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEES
YLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYR
IESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLV

--------------------------------------------------------------

>99218_99218_10_WHSC1L1-RSF1_WHSC1L1_chr8_38194823_ENST00000527502_RSF1_chr11_77402283_ENST00000308488_length(amino acids)=549AA_BP=48
MFQQRKCPLVLSFRLAILCGPRWEPILGGLVWFQVIPSLRFILKLTQEKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENII
PPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERK
ENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRL
RRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEES
YLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYR
IESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLV

--------------------------------------------------------------

>99218_99218_11_WHSC1L1-RSF1_WHSC1L1_chr8_38194823_ENST00000527502_RSF1_chr11_77402283_ENST00000360355_length(amino acids)=549AA_BP=48
MFQQRKCPLVLSFRLAILCGPRWEPILGGLVWFQVIPSLRFILKLTQEKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENII
PPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERK
ENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRL
RRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEES
YLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYR
IESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLV

--------------------------------------------------------------

>99218_99218_12_WHSC1L1-RSF1_WHSC1L1_chr8_38194823_ENST00000527502_RSF1_chr11_77402283_ENST00000480887_length(amino acids)=549AA_BP=48
MFQQRKCPLVLSFRLAILCGPRWEPILGGLVWFQVIPSLRFILKLTQEKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENII
PPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERK
ENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRL
RRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEES
YLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYR
IESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLV

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:38194823/chr11:77402283)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000308488

942_1012

940.0

1442.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000360355

942_1012

909.0

1411.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000480887

942_1012

688.0

1190.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000308488

1080_1083

940.0

1442.0

Compositional bias

Note=Poly-Ala

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000308488

1146_1243

940.0

1442.0

Compositional bias

Note=Arg-rich

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000308488

1286_1292

940.0

1442.0

Compositional bias

Note=Poly-Glu

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000308488

1419_1424

940.0

1442.0

Compositional bias

Note=Poly-Glu

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000360355

1080_1083

909.0

1411.0

Compositional bias

Note=Poly-Ala

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000360355

1146_1243

909.0

1411.0

Compositional bias

Note=Arg-rich

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000360355

1286_1292

909.0

1411.0

Compositional bias

Note=Poly-Glu

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000360355

1419_1424

909.0

1411.0

Compositional bias

Note=Poly-Glu

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000480887

1080_1083

688.0

1190.0

Compositional bias

Note=Poly-Ala

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000480887

1146_1243

688.0

1190.0

Compositional bias

Note=Arg-rich

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000480887

1286_1292

688.0

1190.0

Compositional bias

Note=Poly-Glu

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000480887

1419_1424

688.0

1190.0

Compositional bias

Note=Poly-Glu

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000480887

875_884

688.0

1190.0

Compositional bias

Note=Poly-Glu

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000480887

891_941

688.0

1190.0

Zinc finger

PHD-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000316985

1033_1069

303.3333333333333

646.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000317025

1033_1069

303.3333333333333

1438.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000433384

1033_1069

303.3333333333333

1389.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000316985

1093_1143

303.3333333333333

646.0

Domain

AWS

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000316985

1145_1262

303.3333333333333

646.0

Domain

SET

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000316985

1269_1285

303.3333333333333

646.0

Domain

Post-SET

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000316985

270_333

303.3333333333333

646.0

Domain

PWWP 1

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000316985

960_1022

303.3333333333333

646.0

Domain

PWWP 2

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000317025

1093_1143

303.3333333333333

1438.0

Domain

AWS

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000317025

1145_1262

303.3333333333333

1438.0

Domain

SET

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000317025

1269_1285

303.3333333333333

1438.0

Domain

Post-SET

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000317025

270_333

303.3333333333333

1438.0

Domain

PWWP 1

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000317025

960_1022

303.3333333333333

1438.0

Domain

PWWP 2

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000433384

1093_1143

303.3333333333333

1389.0

Domain

AWS

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000433384

1145_1262

303.3333333333333

1389.0

Domain

SET

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000433384

1269_1285

303.3333333333333

1389.0

Domain

Post-SET

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000433384

270_333

303.3333333333333

1389.0

Domain

PWWP 1

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000433384

960_1022

303.3333333333333

1389.0

Domain

PWWP 2

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000316985

1321_1368

303.3333333333333

646.0

Zinc finger

PHD-type 4%3B atypical

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000316985

701_748

303.3333333333333

646.0

Zinc finger

PHD-type 1

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000316985

749_805

303.3333333333333

646.0

Zinc finger

PHD-type 2

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000316985

862_955

303.3333333333333

646.0

Zinc finger

PHD-type 3

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000317025

1321_1368

303.3333333333333

1438.0

Zinc finger

PHD-type 4%3B atypical

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000317025

701_748

303.3333333333333

1438.0

Zinc finger

PHD-type 1

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000317025

749_805

303.3333333333333

1438.0

Zinc finger

PHD-type 2

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000317025

862_955

303.3333333333333

1438.0

Zinc finger

PHD-type 3

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000433384

1321_1368

303.3333333333333

1389.0

Zinc finger

PHD-type 4%3B atypical

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000433384

701_748

303.3333333333333

1389.0

Zinc finger

PHD-type 1

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000433384

749_805

303.3333333333333

1389.0

Zinc finger

PHD-type 2

Hgene

WHSC1L1

chr8:38194823

chr11:77402283

ENST00000433384

862_955

303.3333333333333

1389.0

Zinc finger

PHD-type 3

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000308488

226_372

940.0

1442.0

Compositional bias

Note=Glu-rich

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000308488

875_884

940.0

1442.0

Compositional bias

Note=Poly-Glu

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000360355

226_372

909.0

1411.0

Compositional bias

Note=Glu-rich

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000360355

875_884

909.0

1411.0

Compositional bias

Note=Poly-Glu

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000480887

226_372

688.0

1190.0

Compositional bias

Note=Glu-rich

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000308488

17_84

940.0

1442.0

Domain

Note=DDT

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000360355

17_84

909.0

1411.0

Domain

Note=DDT

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000480887

17_84

688.0

1190.0

Domain

Note=DDT

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000308488

891_941

940.0

1442.0

Zinc finger

PHD-type

Tgene

RSF1

chr8:38194823

chr11:77402283

ENST00000360355

891_941

909.0

1411.0

Zinc finger

PHD-type

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
WHSC1L1
RSF1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to WHSC1L1-RSF1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to WHSC1L1-RSF1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source