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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:WIPF2-ERBB2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: WIPF2-ERBB2
	FusionPDB ID: 99267
	FusionGDB2.0 ID: 99267
		Hgene	Tgene
	Gene symbol	WIPF2	ERBB2
	Gene ID	147179	2064
	Gene name	WAS/WASL interacting protein family member 2	erb-b2 receptor tyrosine kinase 2
	Synonyms	WICH\|WIRE	CD340\|HER-2\|HER-2/neu\|HER2\|MLN 19\|NEU\|NGL\|TKR1
	Cytomap	17q21.2	17q12
	Type of gene	protein-coding	protein-coding
	Description	WAS/WASL-interacting protein family member 2WASP-binding proteinWASP-interacting protein-related proteinWIP- and CR16-homologous proteinWIP-related protein	receptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologp185erbB2
	Modification date	20200327	20200329
	UniProtAcc	.	P04626
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000494757, ENST00000323571, ENST00000583130, ENST00000585043, ENST00000394103, ENST00000536600,	ENST00000269571, ENST00000406381, ENST00000445658, ENST00000540042, ENST00000540147, ENST00000541774, ENST00000578199, ENST00000584450, ENST00000584601, ENST00000584888,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	40 X 12 X 16=7680	34 X 40 X 10=13600
	# samples	50	43
	** MAII score	log2(50/7680*10)=-3.94110631094643 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(43/13600*10)=-4.9831261814356 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: WIPF2 [Title/Abstract] AND ERBB2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ERBB2(37873733)-WIPF2(38412643), # samples:2 WIPF2(38421398)-ERBB2(37872554), # samples:2
Anticipated loss of major functional domain due to fusion event.	WIPF2-ERBB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. WIPF2-ERBB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. WIPF2-ERBB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. WIPF2-ERBB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ERBB2	GO:0007165	signal transduction	10572067
Tgene	ERBB2	GO:0007166	cell surface receptor signaling pathway	9685399
Tgene	ERBB2	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	7514177
Tgene	ERBB2	GO:0014065	phosphatidylinositol 3-kinase signaling	7556068
Tgene	ERBB2	GO:0018108	peptidyl-tyrosine phosphorylation	12000754
Tgene	ERBB2	GO:0032886	regulation of microtubule-based process	20937854
Tgene	ERBB2	GO:0035556	intracellular signal transduction	19372587
Tgene	ERBB2	GO:0042060	wound healing	12646923
Tgene	ERBB2	GO:0043406	positive regulation of MAP kinase activity	10572067
Tgene	ERBB2	GO:0045785	positive regulation of cell adhesion	7556068
Tgene	ERBB2	GO:0046777	protein autophosphorylation	7556068
Tgene	ERBB2	GO:0050679	positive regulation of epithelial cell proliferation	10572067
Tgene	ERBB2	GO:0071363	cellular response to growth factor stimulus	20010870
Tgene	ERBB2	GO:0090314	positive regulation of protein targeting to membrane	20010870

Fusion gene breakpoints across WIPF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ERBB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-R5-A7ZE-01B	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+
ChimerDB4	STAD	TCGA-R5-A7ZE	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000323571	WIPF2	chr17	38421398	+	ENST00000584601	ERBB2	chr17	37872554	+	3782	1210	240	3464	1074
ENST00000323571	WIPF2	chr17	38421398	+	ENST00000406381	ERBB2	chr17	37872554	+	4083	1210	240	3464	1074
ENST00000323571	WIPF2	chr17	38421398	+	ENST00000541774	ERBB2	chr17	37872554	+	4083	1210	240	3464	1074
ENST00000323571	WIPF2	chr17	38421398	+	ENST00000445658	ERBB2	chr17	37872554	+	3500	1210	240	3464	1074
ENST00000323571	WIPF2	chr17	38421398	+	ENST00000540147	ERBB2	chr17	37872554	+	4083	1210	240	3464	1074
ENST00000323571	WIPF2	chr17	38421398	+	ENST00000584450	ERBB2	chr17	37872554	+	3212	1210	240	2864	874
ENST00000323571	WIPF2	chr17	38421398	+	ENST00000269571	ERBB2	chr17	37872554	+	4083	1210	240	3464	1074
ENST00000323571	WIPF2	chr17	38421398	+	ENST00000578199	ERBB2	chr17	37872554	+	1772	1210	240	1598	452
ENST00000323571	WIPF2	chr17	38421398	+	ENST00000540042	ERBB2	chr17	37872554	+	1768	1210	240	1598	452
ENST00000585043	WIPF2	chr17	38421398	+	ENST00000584601	ERBB2	chr17	37872554	+	3780	1208	238	3462	1074
ENST00000585043	WIPF2	chr17	38421398	+	ENST00000406381	ERBB2	chr17	37872554	+	4081	1208	238	3462	1074
ENST00000585043	WIPF2	chr17	38421398	+	ENST00000541774	ERBB2	chr17	37872554	+	4081	1208	238	3462	1074
ENST00000585043	WIPF2	chr17	38421398	+	ENST00000445658	ERBB2	chr17	37872554	+	3498	1208	238	3462	1074
ENST00000585043	WIPF2	chr17	38421398	+	ENST00000540147	ERBB2	chr17	37872554	+	4081	1208	238	3462	1074
ENST00000585043	WIPF2	chr17	38421398	+	ENST00000584450	ERBB2	chr17	37872554	+	3210	1208	238	2862	874
ENST00000585043	WIPF2	chr17	38421398	+	ENST00000269571	ERBB2	chr17	37872554	+	4081	1208	238	3462	1074
ENST00000585043	WIPF2	chr17	38421398	+	ENST00000578199	ERBB2	chr17	37872554	+	1770	1208	238	1596	452
ENST00000585043	WIPF2	chr17	38421398	+	ENST00000540042	ERBB2	chr17	37872554	+	1766	1208	238	1596	452
ENST00000583130	WIPF2	chr17	38421398	+	ENST00000584601	ERBB2	chr17	37872554	+	3742	1170	200	3424	1074
ENST00000583130	WIPF2	chr17	38421398	+	ENST00000406381	ERBB2	chr17	37872554	+	4043	1170	200	3424	1074
ENST00000583130	WIPF2	chr17	38421398	+	ENST00000541774	ERBB2	chr17	37872554	+	4043	1170	200	3424	1074
ENST00000583130	WIPF2	chr17	38421398	+	ENST00000445658	ERBB2	chr17	37872554	+	3460	1170	200	3424	1074
ENST00000583130	WIPF2	chr17	38421398	+	ENST00000540147	ERBB2	chr17	37872554	+	4043	1170	200	3424	1074
ENST00000583130	WIPF2	chr17	38421398	+	ENST00000584450	ERBB2	chr17	37872554	+	3172	1170	200	2824	874
ENST00000583130	WIPF2	chr17	38421398	+	ENST00000269571	ERBB2	chr17	37872554	+	4043	1170	200	3424	1074
ENST00000583130	WIPF2	chr17	38421398	+	ENST00000578199	ERBB2	chr17	37872554	+	1732	1170	200	1558	452
ENST00000583130	WIPF2	chr17	38421398	+	ENST00000540042	ERBB2	chr17	37872554	+	1728	1170	200	1558	452
ENST00000323571	WIPF2	chr17	38421398	+	ENST00000584601	ERBB2	chr17	37872553	+	3782	1210	240	3464	1074
ENST00000323571	WIPF2	chr17	38421398	+	ENST00000406381	ERBB2	chr17	37872553	+	4083	1210	240	3464	1074
ENST00000323571	WIPF2	chr17	38421398	+	ENST00000541774	ERBB2	chr17	37872553	+	4083	1210	240	3464	1074
ENST00000323571	WIPF2	chr17	38421398	+	ENST00000445658	ERBB2	chr17	37872553	+	3500	1210	240	3464	1074
ENST00000323571	WIPF2	chr17	38421398	+	ENST00000540147	ERBB2	chr17	37872553	+	4083	1210	240	3464	1074
ENST00000323571	WIPF2	chr17	38421398	+	ENST00000584450	ERBB2	chr17	37872553	+	3212	1210	240	2864	874
ENST00000323571	WIPF2	chr17	38421398	+	ENST00000269571	ERBB2	chr17	37872553	+	4083	1210	240	3464	1074
ENST00000323571	WIPF2	chr17	38421398	+	ENST00000578199	ERBB2	chr17	37872553	+	1772	1210	240	1598	452
ENST00000323571	WIPF2	chr17	38421398	+	ENST00000540042	ERBB2	chr17	37872553	+	1768	1210	240	1598	452
ENST00000585043	WIPF2	chr17	38421398	+	ENST00000584601	ERBB2	chr17	37872553	+	3780	1208	238	3462	1074
ENST00000585043	WIPF2	chr17	38421398	+	ENST00000406381	ERBB2	chr17	37872553	+	4081	1208	238	3462	1074
ENST00000585043	WIPF2	chr17	38421398	+	ENST00000541774	ERBB2	chr17	37872553	+	4081	1208	238	3462	1074
ENST00000585043	WIPF2	chr17	38421398	+	ENST00000445658	ERBB2	chr17	37872553	+	3498	1208	238	3462	1074
ENST00000585043	WIPF2	chr17	38421398	+	ENST00000540147	ERBB2	chr17	37872553	+	4081	1208	238	3462	1074
ENST00000585043	WIPF2	chr17	38421398	+	ENST00000584450	ERBB2	chr17	37872553	+	3210	1208	238	2862	874
ENST00000585043	WIPF2	chr17	38421398	+	ENST00000269571	ERBB2	chr17	37872553	+	4081	1208	238	3462	1074
ENST00000585043	WIPF2	chr17	38421398	+	ENST00000578199	ERBB2	chr17	37872553	+	1770	1208	238	1596	452
ENST00000585043	WIPF2	chr17	38421398	+	ENST00000540042	ERBB2	chr17	37872553	+	1766	1208	238	1596	452
ENST00000583130	WIPF2	chr17	38421398	+	ENST00000584601	ERBB2	chr17	37872553	+	3742	1170	200	3424	1074
ENST00000583130	WIPF2	chr17	38421398	+	ENST00000406381	ERBB2	chr17	37872553	+	4043	1170	200	3424	1074
ENST00000583130	WIPF2	chr17	38421398	+	ENST00000541774	ERBB2	chr17	37872553	+	4043	1170	200	3424	1074
ENST00000583130	WIPF2	chr17	38421398	+	ENST00000445658	ERBB2	chr17	37872553	+	3460	1170	200	3424	1074
ENST00000583130	WIPF2	chr17	38421398	+	ENST00000540147	ERBB2	chr17	37872553	+	4043	1170	200	3424	1074
ENST00000583130	WIPF2	chr17	38421398	+	ENST00000584450	ERBB2	chr17	37872553	+	3172	1170	200	2824	874
ENST00000583130	WIPF2	chr17	38421398	+	ENST00000269571	ERBB2	chr17	37872553	+	4043	1170	200	3424	1074
ENST00000583130	WIPF2	chr17	38421398	+	ENST00000578199	ERBB2	chr17	37872553	+	1732	1170	200	1558	452
ENST00000583130	WIPF2	chr17	38421398	+	ENST00000540042	ERBB2	chr17	37872553	+	1728	1170	200	1558	452

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000323571	ENST00000584601	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.001932456	0.99806756
ENST00000323571	ENST00000406381	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.001410566	0.99858946
ENST00000323571	ENST00000541774	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.001410566	0.99858946
ENST00000323571	ENST00000445658	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.00202501	0.99797505
ENST00000323571	ENST00000540147	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.001410566	0.99858946
ENST00000323571	ENST00000584450	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.004577722	0.9954223
ENST00000323571	ENST00000269571	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.001410566	0.99858946
ENST00000323571	ENST00000578199	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.26691595	0.733084
ENST00000323571	ENST00000540042	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.26672477	0.73327523
ENST00000585043	ENST00000584601	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.001914945	0.998085
ENST00000585043	ENST00000406381	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.001396988	0.99860305
ENST00000585043	ENST00000541774	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.001396988	0.99860305
ENST00000585043	ENST00000445658	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.00199405	0.9980059
ENST00000585043	ENST00000540147	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.001396988	0.99860305
ENST00000585043	ENST00000584450	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.004508247	0.9954918
ENST00000585043	ENST00000269571	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.001396988	0.99860305
ENST00000585043	ENST00000578199	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.26624876	0.73375124
ENST00000585043	ENST00000540042	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.2660192	0.73398083
ENST00000583130	ENST00000584601	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.00154895	0.998451
ENST00000583130	ENST00000406381	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.001216915	0.99878305
ENST00000583130	ENST00000541774	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.001216915	0.99878305
ENST00000583130	ENST00000445658	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.001603851	0.9983961
ENST00000583130	ENST00000540147	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.001216915	0.99878305
ENST00000583130	ENST00000584450	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.00385989	0.99614006
ENST00000583130	ENST00000269571	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.001216915	0.99878305
ENST00000583130	ENST00000578199	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.2471659	0.7528341
ENST00000583130	ENST00000540042	WIPF2	chr17	38421398	+	ERBB2	chr17	37872554	+	0.24632259	0.75367737
ENST00000323571	ENST00000584601	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.001932456	0.99806756
ENST00000323571	ENST00000406381	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.001410566	0.99858946
ENST00000323571	ENST00000541774	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.001410566	0.99858946
ENST00000323571	ENST00000445658	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.00202501	0.99797505
ENST00000323571	ENST00000540147	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.001410566	0.99858946
ENST00000323571	ENST00000584450	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.004577722	0.9954223
ENST00000323571	ENST00000269571	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.001410566	0.99858946
ENST00000323571	ENST00000578199	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.26691595	0.733084
ENST00000323571	ENST00000540042	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.26672477	0.73327523
ENST00000585043	ENST00000584601	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.001914945	0.998085
ENST00000585043	ENST00000406381	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.001396988	0.99860305
ENST00000585043	ENST00000541774	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.001396988	0.99860305
ENST00000585043	ENST00000445658	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.00199405	0.9980059
ENST00000585043	ENST00000540147	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.001396988	0.99860305
ENST00000585043	ENST00000584450	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.004508247	0.9954918
ENST00000585043	ENST00000269571	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.001396988	0.99860305
ENST00000585043	ENST00000578199	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.26624876	0.73375124
ENST00000585043	ENST00000540042	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.2660192	0.73398083
ENST00000583130	ENST00000584601	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.00154895	0.998451
ENST00000583130	ENST00000406381	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.001216915	0.99878305
ENST00000583130	ENST00000541774	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.001216915	0.99878305
ENST00000583130	ENST00000445658	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.001603851	0.9983961
ENST00000583130	ENST00000540147	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.001216915	0.99878305
ENST00000583130	ENST00000584450	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.00385989	0.99614006
ENST00000583130	ENST00000269571	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.001216915	0.99878305
ENST00000583130	ENST00000578199	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.2471659	0.7528341
ENST00000583130	ENST00000540042	WIPF2	chr17	38421398	+	ERBB2	chr17	37872553	+	0.24632259	0.75367737

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>99267_99267_1_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000323571_ERBB2_chr17_37872553_ENST00000269571_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

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>99267_99267_2_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000323571_ERBB2_chr17_37872553_ENST00000406381_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

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>99267_99267_3_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000323571_ERBB2_chr17_37872553_ENST00000445658_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

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>99267_99267_4_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000323571_ERBB2_chr17_37872553_ENST00000540042_length(amino acids)=452AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT

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>99267_99267_5_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000323571_ERBB2_chr17_37872553_ENST00000540147_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

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>99267_99267_6_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000323571_ERBB2_chr17_37872553_ENST00000541774_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

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>99267_99267_7_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000323571_ERBB2_chr17_37872553_ENST00000578199_length(amino acids)=452AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT

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>99267_99267_8_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000323571_ERBB2_chr17_37872553_ENST00000584450_length(amino acids)=874AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN

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>99267_99267_9_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000323571_ERBB2_chr17_37872553_ENST00000584601_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

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>99267_99267_10_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000323571_ERBB2_chr17_37872554_ENST00000269571_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

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>99267_99267_11_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000323571_ERBB2_chr17_37872554_ENST00000406381_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

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>99267_99267_12_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000323571_ERBB2_chr17_37872554_ENST00000445658_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

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>99267_99267_13_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000323571_ERBB2_chr17_37872554_ENST00000540042_length(amino acids)=452AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT

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>99267_99267_14_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000323571_ERBB2_chr17_37872554_ENST00000540147_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_15_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000323571_ERBB2_chr17_37872554_ENST00000541774_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_16_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000323571_ERBB2_chr17_37872554_ENST00000578199_length(amino acids)=452AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT

--------------------------------------------------------------

>99267_99267_17_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000323571_ERBB2_chr17_37872554_ENST00000584450_length(amino acids)=874AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN

--------------------------------------------------------------

>99267_99267_18_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000323571_ERBB2_chr17_37872554_ENST00000584601_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_19_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000583130_ERBB2_chr17_37872553_ENST00000269571_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_20_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000583130_ERBB2_chr17_37872553_ENST00000406381_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_21_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000583130_ERBB2_chr17_37872553_ENST00000445658_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_22_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000583130_ERBB2_chr17_37872553_ENST00000540042_length(amino acids)=452AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT

--------------------------------------------------------------

>99267_99267_23_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000583130_ERBB2_chr17_37872553_ENST00000540147_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_24_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000583130_ERBB2_chr17_37872553_ENST00000541774_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_25_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000583130_ERBB2_chr17_37872553_ENST00000578199_length(amino acids)=452AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT

--------------------------------------------------------------

>99267_99267_26_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000583130_ERBB2_chr17_37872553_ENST00000584450_length(amino acids)=874AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN

--------------------------------------------------------------

>99267_99267_27_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000583130_ERBB2_chr17_37872553_ENST00000584601_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_28_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000583130_ERBB2_chr17_37872554_ENST00000269571_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_29_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000583130_ERBB2_chr17_37872554_ENST00000406381_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_30_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000583130_ERBB2_chr17_37872554_ENST00000445658_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_31_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000583130_ERBB2_chr17_37872554_ENST00000540042_length(amino acids)=452AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT

--------------------------------------------------------------

>99267_99267_32_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000583130_ERBB2_chr17_37872554_ENST00000540147_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_33_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000583130_ERBB2_chr17_37872554_ENST00000541774_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_34_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000583130_ERBB2_chr17_37872554_ENST00000578199_length(amino acids)=452AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT

--------------------------------------------------------------

>99267_99267_35_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000583130_ERBB2_chr17_37872554_ENST00000584450_length(amino acids)=874AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN

--------------------------------------------------------------

>99267_99267_36_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000583130_ERBB2_chr17_37872554_ENST00000584601_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_37_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000585043_ERBB2_chr17_37872553_ENST00000269571_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_38_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000585043_ERBB2_chr17_37872553_ENST00000406381_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_39_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000585043_ERBB2_chr17_37872553_ENST00000445658_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_40_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000585043_ERBB2_chr17_37872553_ENST00000540042_length(amino acids)=452AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT

--------------------------------------------------------------

>99267_99267_41_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000585043_ERBB2_chr17_37872553_ENST00000540147_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_42_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000585043_ERBB2_chr17_37872553_ENST00000541774_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_43_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000585043_ERBB2_chr17_37872553_ENST00000578199_length(amino acids)=452AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT

--------------------------------------------------------------

>99267_99267_44_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000585043_ERBB2_chr17_37872553_ENST00000584450_length(amino acids)=874AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN

--------------------------------------------------------------

>99267_99267_45_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000585043_ERBB2_chr17_37872553_ENST00000584601_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_46_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000585043_ERBB2_chr17_37872554_ENST00000269571_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_47_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000585043_ERBB2_chr17_37872554_ENST00000406381_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_48_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000585043_ERBB2_chr17_37872554_ENST00000445658_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_49_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000585043_ERBB2_chr17_37872554_ENST00000540042_length(amino acids)=452AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT

--------------------------------------------------------------

>99267_99267_50_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000585043_ERBB2_chr17_37872554_ENST00000540147_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_51_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000585043_ERBB2_chr17_37872554_ENST00000541774_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

--------------------------------------------------------------

>99267_99267_52_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000585043_ERBB2_chr17_37872554_ENST00000578199_length(amino acids)=452AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT

--------------------------------------------------------------

>99267_99267_53_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000585043_ERBB2_chr17_37872554_ENST00000584450_length(amino acids)=874AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN

--------------------------------------------------------------

>99267_99267_54_WIPF2-ERBB2_WIPF2_chr17_38421398_ENST00000585043_ERBB2_chr17_37872554_ENST00000584601_length(amino acids)=1074AA_BP=322
MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPKGGLFQG
GVLKLRPVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHSSSAPPPP
PPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPTN
ESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCT
HSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELR
KVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVR
ENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTH
QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQN
EDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGA
GSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPK

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37873733/chr17:38412643)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ERBB2 P04626
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {ECO:0000305}.; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. {ECO:0000269\|PubMed:10358079, ECO:0000269\|PubMed:15380516, ECO:0000269\|PubMed:21555369}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000323571

177_182

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000323571

250_254

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000323571

296_299

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000323571

2_17

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000323571

311_314

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000583130

177_182

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000583130

250_254

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000583130

296_299

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000583130

2_17

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000583130

311_314

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000585043

177_182

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000585043

250_254

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000585043

296_299

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000585043

2_17

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000585043

311_314

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000323571

177_182

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000323571

250_254

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000323571

296_299

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000323571

2_17

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000323571

311_314

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000583130

177_182

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000583130

250_254

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000583130

296_299

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000583130

2_17

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000583130

311_314

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000585043

177_182

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000585043

250_254

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000585043

296_299

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000585043

2_17

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000585043

311_314

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000323571

36_53

323.3333333333333

441.0

Domain

WH2

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000583130

36_53

323.3333333333333

441.0

Domain

WH2

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000585043

36_53

323.3333333333333

441.0

Domain

WH2

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000323571

36_53

323.3333333333333

441.0

Domain

WH2

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000583130

36_53

323.3333333333333

441.0

Domain

WH2

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000585043

36_53

323.3333333333333

441.0

Domain

WH2

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000323571

49_52

323.3333333333333

441.0

Region

Binds actin

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000583130

49_52

323.3333333333333

441.0

Region

Binds actin

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000585043

49_52

323.3333333333333

441.0

Region

Binds actin

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000323571

49_52

323.3333333333333

441.0

Region

Binds actin

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000583130

49_52

323.3333333333333

441.0

Region

Binds actin

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000585043

49_52

323.3333333333333

441.0

Region

Binds actin

Tgene

ERBB2

chr17:38421398

chr17:37872553

ENST00000269571

720_987

504.3333333333333

1256.0

Domain

Protein kinase

Tgene

ERBB2

chr17:38421398

chr17:37872553

ENST00000541774

720_987

489.3333333333333

1241.0

Domain

Protein kinase

Tgene

ERBB2

chr17:38421398

chr17:37872554

ENST00000269571

720_987

504.3333333333333

1256.0

Domain

Protein kinase

Tgene

ERBB2

chr17:38421398

chr17:37872554

ENST00000541774

720_987

489.3333333333333

1241.0

Domain

Protein kinase

Tgene

ERBB2

chr17:38421398

chr17:37872553

ENST00000269571

676_689

504.3333333333333

1256.0

Motif

Note=Nuclear localization signal

Tgene

ERBB2

chr17:38421398

chr17:37872553

ENST00000541774

676_689

489.3333333333333

1241.0

Motif

Note=Nuclear localization signal

Tgene

ERBB2

chr17:38421398

chr17:37872554

ENST00000269571

676_689

504.3333333333333

1256.0

Motif

Note=Nuclear localization signal

Tgene

ERBB2

chr17:38421398

chr17:37872554

ENST00000541774

676_689

489.3333333333333

1241.0

Motif

Note=Nuclear localization signal

Tgene

ERBB2

chr17:38421398

chr17:37872553

ENST00000269571

726_734

504.3333333333333

1256.0

Nucleotide binding

ATP

Tgene

ERBB2

chr17:38421398

chr17:37872553

ENST00000541774

726_734

489.3333333333333

1241.0

Nucleotide binding

ATP

Tgene

ERBB2

chr17:38421398

chr17:37872554

ENST00000269571

726_734

504.3333333333333

1256.0

Nucleotide binding

ATP

Tgene

ERBB2

chr17:38421398

chr17:37872554

ENST00000541774

726_734

489.3333333333333

1241.0

Nucleotide binding

ATP

Tgene

ERBB2

chr17:38421398

chr17:37872553

ENST00000269571

676_1255

504.3333333333333

1256.0

Topological domain

Cytoplasmic

Tgene

ERBB2

chr17:38421398

chr17:37872553

ENST00000541774

676_1255

489.3333333333333

1241.0

Topological domain

Cytoplasmic

Tgene

ERBB2

chr17:38421398

chr17:37872554

ENST00000269571

676_1255

504.3333333333333

1256.0

Topological domain

Cytoplasmic

Tgene

ERBB2

chr17:38421398

chr17:37872554

ENST00000541774

676_1255

489.3333333333333

1241.0

Topological domain

Cytoplasmic

Tgene

ERBB2

chr17:38421398

chr17:37872553

ENST00000269571

653_675

504.3333333333333

1256.0

Transmembrane

Helical

Tgene

ERBB2

chr17:38421398

chr17:37872553

ENST00000541774

653_675

489.3333333333333

1241.0

Transmembrane

Helical

Tgene

ERBB2

chr17:38421398

chr17:37872554

ENST00000269571

653_675

504.3333333333333

1256.0

Transmembrane

Helical

Tgene

ERBB2

chr17:38421398

chr17:37872554

ENST00000541774

653_675

489.3333333333333

1241.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000323571

325_330

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000323571

340_345

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000323571

359_363

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000323571

370_377

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000583130

325_330

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000583130

340_345

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000583130

359_363

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000583130

370_377

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000585043

325_330

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000585043

340_345

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000585043

359_363

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872553

ENST00000585043

370_377

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000323571

325_330

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000323571

340_345

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000323571

359_363

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000323571

370_377

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000583130

325_330

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000583130

340_345

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000583130

359_363

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000583130

370_377

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000585043

325_330

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000585043

340_345

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000585043

359_363

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Hgene

WIPF2

chr17:38421398

chr17:37872554

ENST00000585043

370_377

323.3333333333333

441.0

Compositional bias

Note=Poly-Pro

Tgene

ERBB2

chr17:38421398

chr17:37872553

ENST00000269571

23_652

504.3333333333333

1256.0

Topological domain

Extracellular

Tgene

ERBB2

chr17:38421398

chr17:37872553

ENST00000541774

23_652

489.3333333333333

1241.0

Topological domain

Extracellular

Tgene

ERBB2

chr17:38421398

chr17:37872554

ENST00000269571

23_652

504.3333333333333

1256.0

Topological domain

Extracellular

Tgene

ERBB2

chr17:38421398

chr17:37872554

ENST00000541774

23_652

489.3333333333333

1241.0

Topological domain

Extracellular

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
WIPF2
ERBB2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to WIPF2-ERBB2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to WIPF2-ERBB2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source