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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:XPR1-RFWD2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: XPR1-RFWD2
FusionPDB ID: 99742
FusionGDB2.0 ID: 99742
HgeneTgene
Gene symbol

XPR1

RFWD2

Gene ID

9213

64326

Gene namexenotropic and polytropic retrovirus receptor 1COP1 E3 ubiquitin ligase
SynonymsIBGC6|SLC53A1|SYG1|X3CFAP78|FAP78|RFWD2|RNF200
Cytomap

1q25.3

1q25.1-q25.2

Type of geneprotein-codingprotein-coding
Descriptionxenotropic and polytropic retrovirus receptor 1X-receptorprotein SYG1 homologsolute carrier family 53 (phosphate exporter), member 1xenotropic and polytropic murine leukemia virus receptor X3E3 ubiquitin-protein ligase COP1E3 ubiquitin-protein ligase RFWD2RING finger protein 200RING-type E3 ubiquitin transferase RFWD2constitutive photomorphogenesis protein 1 homologconstitutive photomorphogenic protein 1putative ubiquitin ligase COP1ri
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000367589, ENST00000367590, 
ENST00000467345, 		ENST00000308769, 
ENST00000367669, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score24 X 7 X 12=201628 X 17 X 12=5712
# samples 2727
** MAII scorelog2(27/2016*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/5712*10)=-4.40296466697827
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: XPR1 [Title/Abstract] AND RFWD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RFWD2(176175708)-XPR1(180849212), # samples:2
XPR1(180843078)-RFWD2(176153828), # samples:1
Anticipated loss of major functional domain due to fusion event.XPR1-RFWD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
XPR1-RFWD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
XPR1-RFWD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
XPR1-RFWD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RFWD2-XPR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
RFWD2-XPR1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
RFWD2-XPR1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
RFWD2-XPR1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRFWD2

GO:0010212

response to ionizing radiation

19805145


check buttonFusion gene breakpoints across XPR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RFWD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A07W-01AXPR1chr1

180843078

-RFWD2chr1

176153828

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367590XPR1chr1180843078-ENST00000367669RFWD2chr1176153828-4117200619837941198
ENST00000367590XPR1chr1180843078-ENST00000308769RFWD2chr1176153828-3723200619837221174
ENST00000367589XPR1chr1180843078-ENST00000367669RFWD2chr1176153828-3894178317035711133
ENST00000367589XPR1chr1180843078-ENST00000308769RFWD2chr1176153828-3500178317034991110

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367590ENST00000367669XPR1chr1180843078-RFWD2chr1176153828-0.0002855560.99971443
ENST00000367590ENST00000308769XPR1chr1180843078-RFWD2chr1176153828-0.0007014850.99929845
ENST00000367589ENST00000367669XPR1chr1180843078-RFWD2chr1176153828-0.0003655310.9996345
ENST00000367589ENST00000308769XPR1chr1180843078-RFWD2chr1176153828-0.000426690.9995733

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>99742_99742_1_XPR1-RFWD2_XPR1_chr1_180843078_ENST00000367589_RFWD2_chr1_176153828_ENST00000308769_length(amino acids)=1110AA_BP=536
MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNE
LQSSLDAQKESTGVTTLRQRRKPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVAHV
EVAPFYTCKKINQLISETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVLAAVFKLETDRSIWPLIR
IYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRSNLSHQHLFEIAGFLGILWCLSLLACFFAPISVIPTYVYPLALYGFMVFFLI
NPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFADFWLADQLNSLSVILMDLEYMICFYSLELKWDESKGLLPNNSEERGHSDTMVFFYLWI
VFYIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYYCAIIEDVILRFAWTIQISITSTTLLPHSGDIIATVFAPLEVFRPI
CFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNIDHLYPNFLVNELILKQKQRFEEKRFKLDHSNGHRWQIFQDWLGTDQDN
LDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKVARRNKREEMSGLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQPPGFSGSSQ
TKKQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSRISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRD
CDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFN
LMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEE
IVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSA

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>99742_99742_2_XPR1-RFWD2_XPR1_chr1_180843078_ENST00000367589_RFWD2_chr1_176153828_ENST00000367669_length(amino acids)=1133AA_BP=536
MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNE
LQSSLDAQKESTGVTTLRQRRKPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVAHV
EVAPFYTCKKINQLISETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVLAAVFKLETDRSIWPLIR
IYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRSNLSHQHLFEIAGFLGILWCLSLLACFFAPISVIPTYVYPLALYGFMVFFLI
NPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFADFWLADQLNSLSVILMDLEYMICFYSLELKWDESKGLLPNNSEERGHSDTMVFFYLWI
VFYIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYYCAIIEDVILRFAWTIQISITSTTLLPHSGDIIATVFAPLEVFRPI
CFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNIDHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHRWQIFQDWLGT
DQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKVARRNKREQLEQIQKELSVLEEDIKRVEEMSGLYSPVSEDSTVPQFEAP
SPSHSSIIDSTEYSQPPGFSGSSQTKKQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSRISDDSRTASQLDEFQECLSKFTRYNSVRPL
ATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILW
DGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNT
KQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTF

--------------------------------------------------------------

>99742_99742_3_XPR1-RFWD2_XPR1_chr1_180843078_ENST00000367590_RFWD2_chr1_176153828_ENST00000308769_length(amino acids)=1174AA_BP=601
MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNE
LQSSLDAQKESTGVTTLRQRRKPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVAHV
EVAPFYTCKKINQLISETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVLAAVFKLETDRSIWPLIR
IYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRSNLSHQHLFEIAGFLGILWCLSLLACFFAPISVIPTYVYPLALYGFMVFFLI
NPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFADFWLADQLNSLSVILMDLEYMICFYSLELKWDESKGLLPNNSEESGICHKYTYGVRAI
VQCIPAWLRFIQCLRRYRDTKRAFPHLVNAGKYSTTFFMVTFAALYSTHKERGHSDTMVFFYLWIVFYIISSCYTLIWDLKMDWGLFDKN
AGENTFLREEIVYPQKAYYYCAIIEDVILRFAWTIQISITSTTLLPHSGDIIATVFAPLEVFRPICFDMIEEAYMTKCGHSFCYKCIHQS
LEDNNRCPKCNYVVDNIDHLYPNFLVNELILKQKQRFEEKRFKLDHSNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLEAESH
AAQLQILMEFLKVARRNKREEMSGLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQPPGFSGSSQTKKQPWYNSTLASRRKRLTAHFEDL
EQCYFSTRMSRISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDA
VDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDN
SVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFK
GHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGTIKV

--------------------------------------------------------------

>99742_99742_4_XPR1-RFWD2_XPR1_chr1_180843078_ENST00000367590_RFWD2_chr1_176153828_ENST00000367669_length(amino acids)=1198AA_BP=601
MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDEDTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNE
LQSSLDAQKESTGVTTLRQRRKPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKILKKHDKILETSRGADWRVAHV
EVAPFYTCKKINQLISETEAVVTNELEDGDRQKAMKRLRVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVLAAVFKLETDRSIWPLIR
IYRGGFLLIEFLFLLGINTYGWRQAGVNHVLIFELNPRSNLSHQHLFEIAGFLGILWCLSLLACFFAPISVIPTYVYPLALYGFMVFFLI
NPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFADFWLADQLNSLSVILMDLEYMICFYSLELKWDESKGLLPNNSEESGICHKYTYGVRAI
VQCIPAWLRFIQCLRRYRDTKRAFPHLVNAGKYSTTFFMVTFAALYSTHKERGHSDTMVFFYLWIVFYIISSCYTLIWDLKMDWGLFDKN
AGENTFLREEIVYPQKAYYYCAIIEDVILRFAWTIQISITSTTLLPHSGDIIATVFAPLEVFRPICFDMIEEAYMTKCGHSFCYKCIHQS
LEDNNRCPKCNYVVDNIDHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHRWQIFQDWLGTDQDNLDLANVNLMLELLVQKKKQLE
AESHAAQLQILMEFLKVARRNKREQLEQIQKELSVLEEDIKRVEEMSGLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQPPGFSGSSQT
KKQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSRISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDC
DYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNL
MDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEI
VSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAV

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:176175708/chr1:180849212)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-12141_177537.6666666666666632.0DomainSPX
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-13151_177602.6666666666666697.0DomainSPX
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-1214158_165537.6666666666666632.0RegionImportant for inositol polyphosphate binding
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-1315158_165602.6666666666666697.0RegionImportant for inositol polyphosphate binding
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-12141_236537.6666666666666632.0Topological domainCytoplasmic
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-1214258_264537.6666666666666632.0Topological domainExtracellular
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-1214286_318537.6666666666666632.0Topological domainCytoplasmic
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-1214340_345537.6666666666666632.0Topological domainExtracellular
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-1214369_376537.6666666666666632.0Topological domainCytoplasmic
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-1214398_402537.6666666666666632.0Topological domainExtracellular
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-1214424_473537.6666666666666632.0Topological domainCytoplasmic
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-1214497_507537.6666666666666632.0Topological domainExtracellular
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-13151_236602.6666666666666697.0Topological domainCytoplasmic
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-1315258_264602.6666666666666697.0Topological domainExtracellular
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-1315286_318602.6666666666666697.0Topological domainCytoplasmic
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-1315340_345602.6666666666666697.0Topological domainExtracellular
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-1315369_376602.6666666666666697.0Topological domainCytoplasmic
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-1315398_402602.6666666666666697.0Topological domainExtracellular
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-1315424_473602.6666666666666697.0Topological domainCytoplasmic
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-1315497_507602.6666666666666697.0Topological domainExtracellular
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-1214237_257537.6666666666666632.0TransmembraneHelical
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-1214265_285537.6666666666666632.0TransmembraneHelical
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-1214319_339537.6666666666666632.0TransmembraneHelical
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-1214346_368537.6666666666666632.0TransmembraneHelical
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-1214377_397537.6666666666666632.0TransmembraneHelical
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-1214403_423537.6666666666666632.0TransmembraneHelical
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-1214474_496537.6666666666666632.0TransmembraneHelical
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-1214508_528537.6666666666666632.0TransmembraneHelical
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-1315237_257602.6666666666666697.0TransmembraneHelical
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-1315265_285602.6666666666666697.0TransmembraneHelical
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-1315319_339602.6666666666666697.0TransmembraneHelical
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-1315346_368602.6666666666666697.0TransmembraneHelical
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-1315377_397602.6666666666666697.0TransmembraneHelical
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-1315403_423602.6666666666666697.0TransmembraneHelical
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-1315474_496602.6666666666666697.0TransmembraneHelical
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-1315508_528602.6666666666666697.0TransmembraneHelical
TgeneRFWD2chr1:180843078chr1:176153828ENST00000308769019233_301135.66666666666666708.0Coiled coilOntology_term=ECO:0000255
TgeneRFWD2chr1:180843078chr1:176153828ENST00000367669020233_301135.66666666666666732.0Coiled coilOntology_term=ECO:0000255
TgeneRFWD2chr1:180843078chr1:176153828ENST00000308769019195_206135.66666666666666708.0MotifNote=Nuclear localization signal 2
TgeneRFWD2chr1:180843078chr1:176153828ENST00000308769019235_245135.66666666666666708.0MotifNuclear export signal
TgeneRFWD2chr1:180843078chr1:176153828ENST00000367669020195_206135.66666666666666732.0MotifNote=Nuclear localization signal 2
TgeneRFWD2chr1:180843078chr1:176153828ENST00000367669020235_245135.66666666666666732.0MotifNuclear export signal
TgeneRFWD2chr1:180843078chr1:176153828ENST00000308769019419_458135.66666666666666708.0RepeatNote=WD 1
TgeneRFWD2chr1:180843078chr1:176153828ENST00000308769019468_508135.66666666666666708.0RepeatNote=WD 2
TgeneRFWD2chr1:180843078chr1:176153828ENST00000308769019511_551135.66666666666666708.0RepeatNote=WD 3
TgeneRFWD2chr1:180843078chr1:176153828ENST00000308769019553_593135.66666666666666708.0RepeatNote=WD 4
TgeneRFWD2chr1:180843078chr1:176153828ENST00000308769019597_635135.66666666666666708.0RepeatNote=WD 5
TgeneRFWD2chr1:180843078chr1:176153828ENST00000308769019638_677135.66666666666666708.0RepeatNote=WD 6
TgeneRFWD2chr1:180843078chr1:176153828ENST00000308769019691_729135.66666666666666708.0RepeatNote=WD 7
TgeneRFWD2chr1:180843078chr1:176153828ENST00000367669020419_458135.66666666666666732.0RepeatNote=WD 1
TgeneRFWD2chr1:180843078chr1:176153828ENST00000367669020468_508135.66666666666666732.0RepeatNote=WD 2
TgeneRFWD2chr1:180843078chr1:176153828ENST00000367669020511_551135.66666666666666732.0RepeatNote=WD 3
TgeneRFWD2chr1:180843078chr1:176153828ENST00000367669020553_593135.66666666666666732.0RepeatNote=WD 4
TgeneRFWD2chr1:180843078chr1:176153828ENST00000367669020597_635135.66666666666666732.0RepeatNote=WD 5
TgeneRFWD2chr1:180843078chr1:176153828ENST00000367669020638_677135.66666666666666732.0RepeatNote=WD 6
TgeneRFWD2chr1:180843078chr1:176153828ENST00000367669020691_729135.66666666666666732.0RepeatNote=WD 7
TgeneRFWD2chr1:180843078chr1:176153828ENST00000308769019136_174135.66666666666666708.0Zinc fingerRING-type
TgeneRFWD2chr1:180843078chr1:176153828ENST00000367669020136_174135.66666666666666732.0Zinc fingerRING-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-1214439_643537.6666666666666632.0DomainEXS
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-1315439_643602.6666666666666697.0DomainEXS
HgeneXPR1chr1:180843078chr1:176153828ENST00000367589-1214529_696537.6666666666666632.0Topological domainCytoplasmic
HgeneXPR1chr1:180843078chr1:176153828ENST00000367590-1315529_696602.6666666666666697.0Topological domainCytoplasmic
TgeneRFWD2chr1:180843078chr1:176153828ENST000003087690192_110135.66666666666666708.0Compositional biasNote=Ser-rich
TgeneRFWD2chr1:180843078chr1:176153828ENST000003676690202_110135.66666666666666732.0Compositional biasNote=Ser-rich
TgeneRFWD2chr1:180843078chr1:176153828ENST00000308769019109_113135.66666666666666708.0MotifNote=Nuclear localization signal 1
TgeneRFWD2chr1:180843078chr1:176153828ENST00000367669020109_113135.66666666666666732.0MotifNote=Nuclear localization signal 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
XPR1
RFWD2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to XPR1-RFWD2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to XPR1-RFWD2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource