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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:XRCC5-RPL37A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: XRCC5-RPL37A
FusionPDB ID: 99770
FusionGDB2.0 ID: 99770
HgeneTgene
Gene symbol

XRCC5

RPL37A

Gene ID

7520

6168

Gene nameX-ray repair cross complementing 5ribosomal protein L37a
SynonymsKARP-1|KARP1|KU80|KUB2|Ku86|NFIVL37A
Cytomap

2q35

2q35

Type of geneprotein-codingprotein-coding
DescriptionX-ray repair cross-complementing protein 586 kDa subunit of Ku antigenATP-dependent DNA helicase 2 subunit 2ATP-dependent DNA helicase II 80 kDa subunitCTC box-binding factor 85 kDa subunitCTC85CTCBFDNA repair protein XRCC5Ku autoantigen, 80kDaKu60S ribosomal protein L37alarge ribosomal subunit protein eL43
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000392132, ENST00000392133, 
ENST00000471649, 		ENST00000427280, 
ENST00000441179, ENST00000456586, 
ENST00000598925, ENST00000446558, 
ENST00000491306, ENST00000600880, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 10 X 7=91023 X 13 X 5=1495
# samples 1226
** MAII scorelog2(12/910*10)=-2.92283213947754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/1495*10)=-2.52356195605701
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: XRCC5 [Title/Abstract] AND RPL37A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)XRCC5(216974180)-RPL37A(217363992), # samples:1
XRCC5(216974180)-RPL37A(217364672), # samples:1
Anticipated loss of major functional domain due to fusion event.XRCC5-RPL37A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
XRCC5-RPL37A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
XRCC5-RPL37A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
XRCC5-RPL37A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneXRCC5

GO:0002218

activation of innate immune response

28712728

HgeneXRCC5

GO:0006303

double-strand break repair via nonhomologous end joining

26359349

HgeneXRCC5

GO:0045860

positive regulation of protein kinase activity

22504299

HgeneXRCC5

GO:0071480

cellular response to gamma radiation

26359349


check buttonFusion gene breakpoints across XRCC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPL37A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4PE-01AXRCC5chr2

216974180

+RPL37Achr2

217364672

+
ChimerDB4STADTCGA-HU-A4G2XRCC5chr2

216974180

+RPL37Achr2

217363992

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392133XRCC5chr2216974180+ENST00000491306RPL37Achr2217363992+290548271757228
ENST00000392133XRCC5chr2216974180+ENST00000600880RPL37Achr2217363992+87948271697208
ENST00000392133XRCC5chr2216974180+ENST00000446558RPL37Achr2217363992+95448271706211
ENST00000392132XRCC5chr2216974180+ENST00000491306RPL37Achr2217363992+2584161983585132
ENST00000392132XRCC5chr2216974180+ENST00000600880RPL37Achr2217363992+5581614062135
ENST00000392132XRCC5chr2216974180+ENST00000446558RPL37Achr2217363992+6331613912130
ENST00000392133XRCC5chr2216974180+ENST00000491306RPL37Achr2217364672+277648271628185
ENST00000392133XRCC5chr2216974180+ENST00000600880RPL37Achr2217364672+75048271568165
ENST00000392133XRCC5chr2216974180+ENST00000446558RPL37Achr2217364672+82548271577168
ENST00000392133XRCC5chr2216974180+ENST00000456586RPL37Achr2217364672+68848271628185
ENST00000392133XRCC5chr2216974180+ENST00000598925RPL37Achr2217364672+80548271604177
ENST00000392133XRCC5chr2216974180+ENST00000427280RPL37Achr2217364672+86748271688205
ENST00000392133XRCC5chr2216974180+ENST00000441179RPL37Achr2217364672+84148271604177
ENST00000392132XRCC5chr2216974180+ENST00000491306RPL37Achr2217364672+2455161854456132
ENST00000392132XRCC5chr2216974180+ENST00000600880RPL37Achr2217364672+429161277292
ENST00000392132XRCC5chr2216974180+ENST00000446558RPL37Achr2217364672+50416136224112
ENST00000392132XRCC5chr2216974180+ENST00000456586RPL37Achr2217364672+3671615630783
ENST00000392132XRCC5chr2216974180+ENST00000598925RPL37Achr2217364672+48416133824104
ENST00000392132XRCC5chr2216974180+ENST00000427280RPL37Achr2217364672+5461613972132
ENST00000392132XRCC5chr2216974180+ENST00000441179RPL37Achr2217364672+52016133824104

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392133ENST00000491306XRCC5chr2216974180+RPL37Achr2217363992+0.0437026170.9562974
ENST00000392133ENST00000600880XRCC5chr2216974180+RPL37Achr2217363992+0.138469890.86153007
ENST00000392133ENST00000446558XRCC5chr2216974180+RPL37Achr2217363992+0.130408230.8695917
ENST00000392132ENST00000491306XRCC5chr2216974180+RPL37Achr2217363992+0.032097860.96790206
ENST00000392132ENST00000600880XRCC5chr2216974180+RPL37Achr2217363992+0.1092700960.89072984
ENST00000392132ENST00000446558XRCC5chr2216974180+RPL37Achr2217363992+0.127647950.87235206
ENST00000392133ENST00000491306XRCC5chr2216974180+RPL37Achr2217364672+0.291225140.70877486
ENST00000392133ENST00000600880XRCC5chr2216974180+RPL37Achr2217364672+0.28120590.71879417
ENST00000392133ENST00000446558XRCC5chr2216974180+RPL37Achr2217364672+0.287965540.7120345
ENST00000392133ENST00000456586XRCC5chr2216974180+RPL37Achr2217364672+0.223821310.7761787
ENST00000392133ENST00000598925XRCC5chr2216974180+RPL37Achr2217364672+0.223424020.776576
ENST00000392133ENST00000427280XRCC5chr2216974180+RPL37Achr2217364672+0.201970770.79802924
ENST00000392133ENST00000441179XRCC5chr2216974180+RPL37Achr2217364672+0.174986750.8250133
ENST00000392132ENST00000491306XRCC5chr2216974180+RPL37Achr2217364672+0.462907640.5370923
ENST00000392132ENST00000600880XRCC5chr2216974180+RPL37Achr2217364672+0.56962010.43037996
ENST00000392132ENST00000446558XRCC5chr2216974180+RPL37Achr2217364672+0.50405730.4959427
ENST00000392132ENST00000456586XRCC5chr2216974180+RPL37Achr2217364672+0.52766320.47233683
ENST00000392132ENST00000598925XRCC5chr2216974180+RPL37Achr2217364672+0.298367740.7016322
ENST00000392132ENST00000427280XRCC5chr2216974180+RPL37Achr2217364672+0.185182330.81481767
ENST00000392132ENST00000441179XRCC5chr2216974180+RPL37Achr2217364672+0.220732810.7792672

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>99770_99770_1_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392132_RPL37A_chr2_217363992_ENST00000446558_length(amino acids)=130AA_BP=5
MLLFHSVVRPGTASHCLHAGTTVPDPHSSSLHLGFATERASVLGVLADFNFLHHFPEGGPIAGPVFTDDPDFLGTFGLIPRPHHVAGPQA

--------------------------------------------------------------

>99770_99770_2_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392132_RPL37A_chr2_217363992_ENST00000491306_length(amino acids)=132AA_BP=
MRSVQEQPGQCGENSISTQNTKISQVWWCVPVIPATQEAEAGESLEPKKWRLKWAKTGILHSSLGNRDSASKTNKKTNCNLKTKVYSWLQ

--------------------------------------------------------------

>99770_99770_3_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392132_RPL37A_chr2_217363992_ENST00000600880_length(amino acids)=135AA_BP=1
MHLVHLGLLRLLVRPGTASHCLHAGTTVPDPHSSSLHLGFATERASVLGVLADFNFLHHFPEGGPIAGPVFTDDPDFLGTFGLIPRPHHV

--------------------------------------------------------------

>99770_99770_4_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392132_RPL37A_chr2_217364672_ENST00000427280_length(amino acids)=132AA_BP=1
MHLVHLGLLRLPAFSSSSISRVHGDLVPFWHLLMVKTHQGLPLLSILCTHFLVRPGTASHCLHAGTTVPDPHSSSLHLGLIPRPHHVAGP

--------------------------------------------------------------

>99770_99770_5_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392132_RPL37A_chr2_217364672_ENST00000441179_length(amino acids)=104AA_BP=1
MHLVHLGLLRLPAFSSSSISRVHGDLVPFWHLCTSRHRQPLSSCRNHSARSPQLVSSSWSYSPTAPCCRSSGALVASSGREPAVSQLASG

--------------------------------------------------------------

>99770_99770_6_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392132_RPL37A_chr2_217364672_ENST00000446558_length(amino acids)=112AA_BP=0
MAMLQSRSAATVCDLMCSSLKWLLSQTSPPPMLFAVIPFCCTSRHRQPLSSCRNHSARSPQLVSSSWSYSPTAPCCRSSGALVASSGREP

--------------------------------------------------------------

>99770_99770_7_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392132_RPL37A_chr2_217364672_ENST00000456586_length(amino acids)=83AA_BP=1

--------------------------------------------------------------

>99770_99770_8_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392132_RPL37A_chr2_217364672_ENST00000491306_length(amino acids)=132AA_BP=
MRSVQEQPGQCGENSISTQNTKISQVWWCVPVIPATQEAEAGESLEPKKWRLKWAKTGILHSSLGNRDSASKTNKKTNCNLKTKVYSWLQ

--------------------------------------------------------------

>99770_99770_9_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392132_RPL37A_chr2_217364672_ENST00000598925_length(amino acids)=104AA_BP=1
MHLVHLGLLRLPAFSSSSISRVHGDLVPFWHLCTSRHRQPLSSCRNHSARSPQLVSSSWSYSPTAPCCRSSGALVASSGREPAVSQLASG

--------------------------------------------------------------

>99770_99770_10_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392132_RPL37A_chr2_217364672_ENST00000600880_length(amino acids)=92AA_BP=1
MHLVHLGLLRLLVRPGTASHCLHAGTTVPDPHSSSLHLGLIPRPHHVAGPQALWSLLPGGNLPCRNSLPVDKRQIAERAASFPARPERGG

--------------------------------------------------------------

>99770_99770_11_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392133_RPL37A_chr2_217363992_ENST00000446558_length(amino acids)=211AA_BP=1
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF
RPSRKRSGSFRYLPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGK

--------------------------------------------------------------

>99770_99770_12_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392133_RPL37A_chr2_217363992_ENST00000491306_length(amino acids)=228AA_BP=1
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF
RPSRKRSGSFRYLPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGK

--------------------------------------------------------------

>99770_99770_13_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392133_RPL37A_chr2_217363992_ENST00000600880_length(amino acids)=208AA_BP=1
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF
RPSRKRSGSFRYLPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGK

--------------------------------------------------------------

>99770_99770_14_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392133_RPL37A_chr2_217364672_ENST00000427280_length(amino acids)=205AA_BP=1
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF
RPSRKRSGSFRYLPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKTKMKRRAVGIWHCGSCMKTVAGGAWTYKKMSAENGQQREPLMS

--------------------------------------------------------------

>99770_99770_15_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392133_RPL37A_chr2_217364672_ENST00000441179_length(amino acids)=177AA_BP=1
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF

--------------------------------------------------------------

>99770_99770_16_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392133_RPL37A_chr2_217364672_ENST00000446558_length(amino acids)=168AA_BP=1
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF

--------------------------------------------------------------

>99770_99770_17_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392133_RPL37A_chr2_217364672_ENST00000456586_length(amino acids)=185AA_BP=1
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF
RPSRKRSGSFRYLPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKTKMKRRAVGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLK

--------------------------------------------------------------

>99770_99770_18_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392133_RPL37A_chr2_217364672_ENST00000491306_length(amino acids)=185AA_BP=1
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF
RPSRKRSGSFRYLPLVHRKRVATRQVPARKKRPKRLRTGNMVRSGNKTKMKRRAVGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLK

--------------------------------------------------------------

>99770_99770_19_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392133_RPL37A_chr2_217364672_ENST00000598925_length(amino acids)=177AA_BP=1
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF

--------------------------------------------------------------

>99770_99770_20_XRCC5-RPL37A_XRCC5_chr2_216974180_ENST00000392133_RPL37A_chr2_217364672_ENST00000600880_length(amino acids)=165AA_BP=1
MDRTRRETRTTDKICVSGGSNTTRSRLRRNGENVRMLGGNLRMLGGNLRMLGENLRMLGRNLRELGGNLRKLGGNLRMLRVPGHGFPAPF

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:216974180/chr2:217363992)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRPL37Achr2:216974180chr2:217363992ENST000004913060439_601.093.0Zinc fingerNote=C4-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneXRCC5chr2:216974180chr2:217363992ENST00000392132+121478_5197.0733.0Compositional biasNote=Pro-rich
HgeneXRCC5chr2:216974180chr2:217363992ENST00000392133+323478_5197.0733.0Compositional biasNote=Pro-rich
HgeneXRCC5chr2:216974180chr2:217364672ENST00000392132+121478_5197.0733.0Compositional biasNote=Pro-rich
HgeneXRCC5chr2:216974180chr2:217364672ENST00000392133+323478_5197.0733.0Compositional biasNote=Pro-rich
HgeneXRCC5chr2:216974180chr2:217363992ENST00000392132+121251_4607.0733.0DomainNote=Ku
HgeneXRCC5chr2:216974180chr2:217363992ENST00000392133+323251_4607.0733.0DomainNote=Ku
HgeneXRCC5chr2:216974180chr2:217364672ENST00000392132+121251_4607.0733.0DomainNote=Ku
HgeneXRCC5chr2:216974180chr2:217364672ENST00000392133+323251_4607.0733.0DomainNote=Ku
HgeneXRCC5chr2:216974180chr2:217363992ENST00000392132+121720_7287.0733.0MotifNote=EEXXXDL motif
HgeneXRCC5chr2:216974180chr2:217363992ENST00000392133+323720_7287.0733.0MotifNote=EEXXXDL motif
HgeneXRCC5chr2:216974180chr2:217364672ENST00000392132+121720_7287.0733.0MotifNote=EEXXXDL motif
HgeneXRCC5chr2:216974180chr2:217364672ENST00000392133+323720_7287.0733.0MotifNote=EEXXXDL motif
HgeneXRCC5chr2:216974180chr2:217363992ENST00000392132+121138_1657.0733.0RegionNote=Leucine-zipper
HgeneXRCC5chr2:216974180chr2:217363992ENST00000392133+323138_1657.0733.0RegionNote=Leucine-zipper
HgeneXRCC5chr2:216974180chr2:217364672ENST00000392132+121138_1657.0733.0RegionNote=Leucine-zipper
HgeneXRCC5chr2:216974180chr2:217364672ENST00000392133+323138_1657.0733.0RegionNote=Leucine-zipper
TgeneRPL37Achr2:216974180chr2:217364672ENST000004913061439_6044.093.0Zinc fingerNote=C4-type


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
XRCC5
RPL37A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to XRCC5-RPL37A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to XRCC5-RPL37A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource