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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:YAP1-BIRC2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: YAP1-BIRC2
	FusionPDB ID: 99877
	FusionGDB2.0 ID: 99877
		Hgene	Tgene
	Gene symbol	YAP1	BIRC2
	Gene ID	10413	329
	Gene name	Yes1 associated transcriptional regulator	baculoviral IAP repeat containing 2
	Synonyms	COB1\|YAP\|YAP2\|YAP65\|YKI	API1\|HIAP2\|Hiap-2\|MIHB\|RNF48\|c-IAP1\|cIAP1
	Cytomap	11q22.1	11q22.2
	Type of gene	protein-coding	protein-coding
	Description	transcriptional coactivator YAP165 kDa Yes-associated proteinYes associated protein 1protein yorkie homologyes-associated protein 1yes-associated protein 2yes-associated protein YAP65 homologyorkie homolog	baculoviral IAP repeat-containing protein 2IAP homolog BIAP-2NFR2-TRAF signalling complex proteinRING finger protein 48RING-type E3 ubiquitin transferase BIRC2TNFR2-TRAF-signaling complex protein 2apoptosis inhibitor 1cellular inhibitor of apoptos
	Modification date	20200329	20200320
	UniProtAcc	.	Q13490
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000282441, ENST00000345877, ENST00000524575, ENST00000526343, ENST00000531439, ENST00000537274, ENST00000528834,	ENST00000527910, ENST00000227758, ENST00000530675, ENST00000532672,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	23 X 13 X 14=4186	7 X 11 X 4=308
	# samples	25	9
	** MAII score	log2(25/4186*10)=-4.06557231159362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/308*10)=-1.77493344436523 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: YAP1 [Title/Abstract] AND BIRC2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	BIRC2(102221674)-YAP1(102033187), # samples:1 YAP1(102080295)-BIRC2(102248226), # samples:1 YAP1(101985125)-BIRC2(102233626), # samples:1 YAP1(102080295)-BIRC2(102248227), # samples:1 YAP1(102080295)-BIRC2(102248410), # samples:1 YAP1(101985125)-BIRC2(102233627), # samples:1 YAP1(101985124)-BIRC2(102233626), # samples:1
Anticipated loss of major functional domain due to fusion event.	BIRC2-YAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BIRC2-YAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. YAP1-BIRC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. YAP1-BIRC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. YAP1-BIRC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. YAP1-BIRC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. YAP1-BIRC2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. YAP1-BIRC2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. YAP1-BIRC2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. YAP1-BIRC2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	YAP1	GO:0006974	cellular response to DNA damage stimulus	18280240
Hgene	YAP1	GO:0008283	cell proliferation	17974916
Hgene	YAP1	GO:0032570	response to progesterone	16772533
Hgene	YAP1	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	16772533
Hgene	YAP1	GO:0045893	positive regulation of transcription, DNA-templated	20368466
Hgene	YAP1	GO:0045944	positive regulation of transcription by RNA polymerase II	25796446
Hgene	YAP1	GO:0050767	regulation of neurogenesis	25433207
Hgene	YAP1	GO:0050847	progesterone receptor signaling pathway	16772533
Hgene	YAP1	GO:0060242	contact inhibition	17974916
Hgene	YAP1	GO:0065003	protein-containing complex assembly	20368466
Hgene	YAP1	GO:0071480	cellular response to gamma radiation	18280240
Hgene	YAP1	GO:0072091	regulation of stem cell proliferation	25433207
Tgene	BIRC2	GO:0000209	protein polyubiquitination	11907583
Tgene	BIRC2	GO:0043066	negative regulation of apoptotic process	21525013
Tgene	BIRC2	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	11907583
Tgene	BIRC2	GO:0051726	regulation of cell cycle	15665297
Tgene	BIRC2	GO:1902523	positive regulation of protein K63-linked ubiquitination	21931591
Tgene	BIRC2	GO:1902524	positive regulation of protein K48-linked ubiquitination	21931591
Tgene	BIRC2	GO:1902527	positive regulation of protein monoubiquitination	21931591

Fusion gene breakpoints across YAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BIRC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-22-1016	YAP1	chr11	102080295	+	BIRC2	chr11	102248226	+
ChimerDB4	LUSC	TCGA-22-1016	YAP1	chr11	102080295	+	BIRC2	chr11	102248227	+
ChimerDB4	LUSC	TCGA-22-1016	YAP1	chr11	102080295	+	BIRC2	chr11	102248410	+
ChimerDB4	UCEC	TCGA-KP-A3VZ-01A	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+
ChimerDB4	UCEC	TCGA-KP-A3VZ-01A	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+
ChimerDB4	UCEC	TCGA-KP-A3VZ	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000526343	YAP1	chr11	101985125	+	ENST00000530675	BIRC2	chr11	102233626	+	1875	960	388	1821	477
ENST00000526343	YAP1	chr11	101985125	+	ENST00000227758	BIRC2	chr11	102233626	+	2309	960	388	1821	477
ENST00000526343	YAP1	chr11	101985125	+	ENST00000532672	BIRC2	chr11	102233626	+	2308	960	388	1821	477
ENST00000282441	YAP1	chr11	101985125	+	ENST00000530675	BIRC2	chr11	102233626	+	1875	960	388	1821	477
ENST00000282441	YAP1	chr11	101985125	+	ENST00000227758	BIRC2	chr11	102233626	+	2309	960	388	1821	477
ENST00000282441	YAP1	chr11	101985125	+	ENST00000532672	BIRC2	chr11	102233626	+	2308	960	388	1821	477
ENST00000537274	YAP1	chr11	101985125	+	ENST00000530675	BIRC2	chr11	102233626	+	1857	942	370	1803	477
ENST00000537274	YAP1	chr11	101985125	+	ENST00000227758	BIRC2	chr11	102233626	+	2291	942	370	1803	477
ENST00000537274	YAP1	chr11	101985125	+	ENST00000532672	BIRC2	chr11	102233626	+	2290	942	370	1803	477
ENST00000345877	YAP1	chr11	101985125	+	ENST00000530675	BIRC2	chr11	102233626	+	1857	942	370	1803	477
ENST00000345877	YAP1	chr11	101985125	+	ENST00000227758	BIRC2	chr11	102233626	+	2291	942	370	1803	477
ENST00000345877	YAP1	chr11	101985125	+	ENST00000532672	BIRC2	chr11	102233626	+	2290	942	370	1803	477
ENST00000531439	YAP1	chr11	101985125	+	ENST00000530675	BIRC2	chr11	102233626	+	1487	572	0	1433	477
ENST00000531439	YAP1	chr11	101985125	+	ENST00000227758	BIRC2	chr11	102233626	+	1921	572	0	1433	477
ENST00000531439	YAP1	chr11	101985125	+	ENST00000532672	BIRC2	chr11	102233626	+	1920	572	0	1433	477
ENST00000524575	YAP1	chr11	101985125	+	ENST00000530675	BIRC2	chr11	102233626	+	1398	483	262	1344	360
ENST00000524575	YAP1	chr11	101985125	+	ENST00000227758	BIRC2	chr11	102233626	+	1832	483	262	1344	360
ENST00000524575	YAP1	chr11	101985125	+	ENST00000532672	BIRC2	chr11	102233626	+	1831	483	262	1344	360
ENST00000526343	YAP1	chr11	101985125	+	ENST00000530675	BIRC2	chr11	102233627	+	1875	960	388	1821	477
ENST00000526343	YAP1	chr11	101985125	+	ENST00000227758	BIRC2	chr11	102233627	+	2309	960	388	1821	477
ENST00000526343	YAP1	chr11	101985125	+	ENST00000532672	BIRC2	chr11	102233627	+	2308	960	388	1821	477
ENST00000282441	YAP1	chr11	101985125	+	ENST00000530675	BIRC2	chr11	102233627	+	1875	960	388	1821	477
ENST00000282441	YAP1	chr11	101985125	+	ENST00000227758	BIRC2	chr11	102233627	+	2309	960	388	1821	477
ENST00000282441	YAP1	chr11	101985125	+	ENST00000532672	BIRC2	chr11	102233627	+	2308	960	388	1821	477
ENST00000537274	YAP1	chr11	101985125	+	ENST00000530675	BIRC2	chr11	102233627	+	1857	942	370	1803	477
ENST00000537274	YAP1	chr11	101985125	+	ENST00000227758	BIRC2	chr11	102233627	+	2291	942	370	1803	477
ENST00000537274	YAP1	chr11	101985125	+	ENST00000532672	BIRC2	chr11	102233627	+	2290	942	370	1803	477
ENST00000345877	YAP1	chr11	101985125	+	ENST00000530675	BIRC2	chr11	102233627	+	1857	942	370	1803	477
ENST00000345877	YAP1	chr11	101985125	+	ENST00000227758	BIRC2	chr11	102233627	+	2291	942	370	1803	477
ENST00000345877	YAP1	chr11	101985125	+	ENST00000532672	BIRC2	chr11	102233627	+	2290	942	370	1803	477
ENST00000531439	YAP1	chr11	101985125	+	ENST00000530675	BIRC2	chr11	102233627	+	1487	572	0	1433	477
ENST00000531439	YAP1	chr11	101985125	+	ENST00000227758	BIRC2	chr11	102233627	+	1921	572	0	1433	477
ENST00000531439	YAP1	chr11	101985125	+	ENST00000532672	BIRC2	chr11	102233627	+	1920	572	0	1433	477
ENST00000524575	YAP1	chr11	101985125	+	ENST00000530675	BIRC2	chr11	102233627	+	1398	483	262	1344	360
ENST00000524575	YAP1	chr11	101985125	+	ENST00000227758	BIRC2	chr11	102233627	+	1832	483	262	1344	360
ENST00000524575	YAP1	chr11	101985125	+	ENST00000532672	BIRC2	chr11	102233627	+	1831	483	262	1344	360
ENST00000526343	YAP1	chr11	101985124	+	ENST00000530675	BIRC2	chr11	102233626	+	1875	960	388	1821	477
ENST00000526343	YAP1	chr11	101985124	+	ENST00000227758	BIRC2	chr11	102233626	+	2309	960	388	1821	477
ENST00000526343	YAP1	chr11	101985124	+	ENST00000532672	BIRC2	chr11	102233626	+	2308	960	388	1821	477
ENST00000282441	YAP1	chr11	101985124	+	ENST00000530675	BIRC2	chr11	102233626	+	1875	960	388	1821	477
ENST00000282441	YAP1	chr11	101985124	+	ENST00000227758	BIRC2	chr11	102233626	+	2309	960	388	1821	477
ENST00000282441	YAP1	chr11	101985124	+	ENST00000532672	BIRC2	chr11	102233626	+	2308	960	388	1821	477
ENST00000537274	YAP1	chr11	101985124	+	ENST00000530675	BIRC2	chr11	102233626	+	1857	942	370	1803	477
ENST00000537274	YAP1	chr11	101985124	+	ENST00000227758	BIRC2	chr11	102233626	+	2291	942	370	1803	477
ENST00000537274	YAP1	chr11	101985124	+	ENST00000532672	BIRC2	chr11	102233626	+	2290	942	370	1803	477
ENST00000345877	YAP1	chr11	101985124	+	ENST00000530675	BIRC2	chr11	102233626	+	1857	942	370	1803	477
ENST00000345877	YAP1	chr11	101985124	+	ENST00000227758	BIRC2	chr11	102233626	+	2291	942	370	1803	477
ENST00000345877	YAP1	chr11	101985124	+	ENST00000532672	BIRC2	chr11	102233626	+	2290	942	370	1803	477
ENST00000531439	YAP1	chr11	101985124	+	ENST00000530675	BIRC2	chr11	102233626	+	1487	572	0	1433	477
ENST00000531439	YAP1	chr11	101985124	+	ENST00000227758	BIRC2	chr11	102233626	+	1921	572	0	1433	477
ENST00000531439	YAP1	chr11	101985124	+	ENST00000532672	BIRC2	chr11	102233626	+	1920	572	0	1433	477
ENST00000524575	YAP1	chr11	101985124	+	ENST00000530675	BIRC2	chr11	102233626	+	1398	483	262	1344	360
ENST00000524575	YAP1	chr11	101985124	+	ENST00000227758	BIRC2	chr11	102233626	+	1832	483	262	1344	360
ENST00000524575	YAP1	chr11	101985124	+	ENST00000532672	BIRC2	chr11	102233626	+	1831	483	262	1344	360

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000526343	ENST00000530675	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+	0.001869601	0.9981304
ENST00000526343	ENST00000227758	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+	0.000548679	0.99945134
ENST00000526343	ENST00000532672	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+	0.000544855	0.99945515
ENST00000282441	ENST00000530675	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+	0.001869601	0.9981304
ENST00000282441	ENST00000227758	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+	0.000548679	0.99945134
ENST00000282441	ENST00000532672	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+	0.000544855	0.99945515
ENST00000537274	ENST00000530675	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+	0.001830972	0.99816906
ENST00000537274	ENST00000227758	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+	0.000544569	0.9994554
ENST00000537274	ENST00000532672	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+	0.000541139	0.99945885
ENST00000345877	ENST00000530675	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+	0.001830972	0.99816906
ENST00000345877	ENST00000227758	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+	0.000544569	0.9994554
ENST00000345877	ENST00000532672	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+	0.000541139	0.99945885
ENST00000531439	ENST00000530675	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+	0.001038066	0.9989619
ENST00000531439	ENST00000227758	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+	0.000333133	0.9996669
ENST00000531439	ENST00000532672	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+	0.000333185	0.9996668
ENST00000524575	ENST00000530675	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+	0.000996538	0.99900347
ENST00000524575	ENST00000227758	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+	0.000570526	0.9994294
ENST00000524575	ENST00000532672	YAP1	chr11	101985125	+	BIRC2	chr11	102233626	+	0.000569995	0.99943
ENST00000526343	ENST00000530675	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+	0.001869601	0.9981304
ENST00000526343	ENST00000227758	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+	0.000548679	0.99945134
ENST00000526343	ENST00000532672	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+	0.000544855	0.99945515
ENST00000282441	ENST00000530675	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+	0.001869601	0.9981304
ENST00000282441	ENST00000227758	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+	0.000548679	0.99945134
ENST00000282441	ENST00000532672	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+	0.000544855	0.99945515
ENST00000537274	ENST00000530675	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+	0.001830972	0.99816906
ENST00000537274	ENST00000227758	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+	0.000544569	0.9994554
ENST00000537274	ENST00000532672	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+	0.000541139	0.99945885
ENST00000345877	ENST00000530675	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+	0.001830972	0.99816906
ENST00000345877	ENST00000227758	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+	0.000544569	0.9994554
ENST00000345877	ENST00000532672	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+	0.000541139	0.99945885
ENST00000531439	ENST00000530675	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+	0.001038066	0.9989619
ENST00000531439	ENST00000227758	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+	0.000333133	0.9996669
ENST00000531439	ENST00000532672	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+	0.000333185	0.9996668
ENST00000524575	ENST00000530675	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+	0.000996538	0.99900347
ENST00000524575	ENST00000227758	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+	0.000570526	0.9994294
ENST00000524575	ENST00000532672	YAP1	chr11	101985125	+	BIRC2	chr11	102233627	+	0.000569995	0.99943
ENST00000526343	ENST00000530675	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+	0.001869601	0.9981304
ENST00000526343	ENST00000227758	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+	0.000548679	0.99945134
ENST00000526343	ENST00000532672	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+	0.000544855	0.99945515
ENST00000282441	ENST00000530675	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+	0.001869601	0.9981304
ENST00000282441	ENST00000227758	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+	0.000548679	0.99945134
ENST00000282441	ENST00000532672	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+	0.000544855	0.99945515
ENST00000537274	ENST00000530675	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+	0.001830972	0.99816906
ENST00000537274	ENST00000227758	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+	0.000544569	0.9994554
ENST00000537274	ENST00000532672	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+	0.000541139	0.99945885
ENST00000345877	ENST00000530675	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+	0.001830972	0.99816906
ENST00000345877	ENST00000227758	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+	0.000544569	0.9994554
ENST00000345877	ENST00000532672	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+	0.000541139	0.99945885
ENST00000531439	ENST00000530675	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+	0.001038066	0.9989619
ENST00000531439	ENST00000227758	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+	0.000333133	0.9996669
ENST00000531439	ENST00000532672	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+	0.000333185	0.9996668
ENST00000524575	ENST00000530675	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+	0.000996538	0.99900347
ENST00000524575	ENST00000227758	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+	0.000570526	0.9994294
ENST00000524575	ENST00000532672	YAP1	chr11	101985124	+	BIRC2	chr11	102233626	+	0.000569995	0.99943

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>99877_99877_1_YAP1-BIRC2_YAP1_chr11_101985124_ENST00000282441_BIRC2_chr11_102233626_ENST00000227758_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_2_YAP1-BIRC2_YAP1_chr11_101985124_ENST00000282441_BIRC2_chr11_102233626_ENST00000530675_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_3_YAP1-BIRC2_YAP1_chr11_101985124_ENST00000282441_BIRC2_chr11_102233626_ENST00000532672_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_4_YAP1-BIRC2_YAP1_chr11_101985124_ENST00000345877_BIRC2_chr11_102233626_ENST00000227758_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_5_YAP1-BIRC2_YAP1_chr11_101985124_ENST00000345877_BIRC2_chr11_102233626_ENST00000530675_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_6_YAP1-BIRC2_YAP1_chr11_101985124_ENST00000345877_BIRC2_chr11_102233626_ENST00000532672_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_7_YAP1-BIRC2_YAP1_chr11_101985124_ENST00000524575_BIRC2_chr11_102233626_ENST00000227758_length(amino acids)=360AA_BP=1
MTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLKCEFLIRMKGQEFVDEI
QGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAE
DEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCL
KEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS

--------------------------------------------------------------

>99877_99877_8_YAP1-BIRC2_YAP1_chr11_101985124_ENST00000524575_BIRC2_chr11_102233626_ENST00000530675_length(amino acids)=360AA_BP=1
MTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLKCEFLIRMKGQEFVDEI
QGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAE
DEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCL
KEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS

--------------------------------------------------------------

>99877_99877_9_YAP1-BIRC2_YAP1_chr11_101985124_ENST00000524575_BIRC2_chr11_102233626_ENST00000532672_length(amino acids)=360AA_BP=1
MTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLKCEFLIRMKGQEFVDEI
QGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAE
DEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCL
KEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS

--------------------------------------------------------------

>99877_99877_10_YAP1-BIRC2_YAP1_chr11_101985124_ENST00000526343_BIRC2_chr11_102233626_ENST00000227758_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_11_YAP1-BIRC2_YAP1_chr11_101985124_ENST00000526343_BIRC2_chr11_102233626_ENST00000530675_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_12_YAP1-BIRC2_YAP1_chr11_101985124_ENST00000526343_BIRC2_chr11_102233626_ENST00000532672_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_13_YAP1-BIRC2_YAP1_chr11_101985124_ENST00000531439_BIRC2_chr11_102233626_ENST00000227758_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_14_YAP1-BIRC2_YAP1_chr11_101985124_ENST00000531439_BIRC2_chr11_102233626_ENST00000530675_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_15_YAP1-BIRC2_YAP1_chr11_101985124_ENST00000531439_BIRC2_chr11_102233626_ENST00000532672_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_16_YAP1-BIRC2_YAP1_chr11_101985124_ENST00000537274_BIRC2_chr11_102233626_ENST00000227758_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_17_YAP1-BIRC2_YAP1_chr11_101985124_ENST00000537274_BIRC2_chr11_102233626_ENST00000530675_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_18_YAP1-BIRC2_YAP1_chr11_101985124_ENST00000537274_BIRC2_chr11_102233626_ENST00000532672_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_19_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000282441_BIRC2_chr11_102233626_ENST00000227758_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_20_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000282441_BIRC2_chr11_102233626_ENST00000530675_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_21_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000282441_BIRC2_chr11_102233626_ENST00000532672_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_22_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000282441_BIRC2_chr11_102233627_ENST00000227758_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_23_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000282441_BIRC2_chr11_102233627_ENST00000530675_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_24_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000282441_BIRC2_chr11_102233627_ENST00000532672_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_25_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000345877_BIRC2_chr11_102233626_ENST00000227758_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_26_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000345877_BIRC2_chr11_102233626_ENST00000530675_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_27_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000345877_BIRC2_chr11_102233626_ENST00000532672_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_28_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000345877_BIRC2_chr11_102233627_ENST00000227758_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_29_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000345877_BIRC2_chr11_102233627_ENST00000530675_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_30_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000345877_BIRC2_chr11_102233627_ENST00000532672_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_31_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000524575_BIRC2_chr11_102233626_ENST00000227758_length(amino acids)=360AA_BP=1
MTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLKCEFLIRMKGQEFVDEI
QGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAE
DEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCL
KEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS

--------------------------------------------------------------

>99877_99877_32_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000524575_BIRC2_chr11_102233626_ENST00000530675_length(amino acids)=360AA_BP=1
MTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLKCEFLIRMKGQEFVDEI
QGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAE
DEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCL
KEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS

--------------------------------------------------------------

>99877_99877_33_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000524575_BIRC2_chr11_102233626_ENST00000532672_length(amino acids)=360AA_BP=1
MTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLKCEFLIRMKGQEFVDEI
QGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAE
DEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCL
KEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS

--------------------------------------------------------------

>99877_99877_34_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000524575_BIRC2_chr11_102233627_ENST00000227758_length(amino acids)=360AA_BP=1
MTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLKCEFLIRMKGQEFVDEI
QGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAE
DEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCL
KEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS

--------------------------------------------------------------

>99877_99877_35_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000524575_BIRC2_chr11_102233627_ENST00000530675_length(amino acids)=360AA_BP=1
MTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLKCEFLIRMKGQEFVDEI
QGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAE
DEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCL
KEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS

--------------------------------------------------------------

>99877_99877_36_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000524575_BIRC2_chr11_102233627_ENST00000532672_length(amino acids)=360AA_BP=1
MTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLKCEFLIRMKGQEFVDEI
QGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAE
DEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCL
KEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS

--------------------------------------------------------------

>99877_99877_37_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000526343_BIRC2_chr11_102233626_ENST00000227758_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_38_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000526343_BIRC2_chr11_102233626_ENST00000530675_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_39_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000526343_BIRC2_chr11_102233626_ENST00000532672_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_40_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000526343_BIRC2_chr11_102233627_ENST00000227758_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_41_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000526343_BIRC2_chr11_102233627_ENST00000530675_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_42_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000526343_BIRC2_chr11_102233627_ENST00000532672_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_43_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000531439_BIRC2_chr11_102233626_ENST00000227758_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_44_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000531439_BIRC2_chr11_102233626_ENST00000530675_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_45_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000531439_BIRC2_chr11_102233626_ENST00000532672_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_46_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000531439_BIRC2_chr11_102233627_ENST00000227758_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_47_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000531439_BIRC2_chr11_102233627_ENST00000530675_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_48_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000531439_BIRC2_chr11_102233627_ENST00000532672_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_49_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000537274_BIRC2_chr11_102233626_ENST00000227758_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_50_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000537274_BIRC2_chr11_102233626_ENST00000530675_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_51_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000537274_BIRC2_chr11_102233626_ENST00000532672_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_52_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000537274_BIRC2_chr11_102233627_ENST00000227758_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_53_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000537274_BIRC2_chr11_102233627_ENST00000530675_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

>99877_99877_54_YAP1-BIRC2_YAP1_chr11_101985125_ENST00000537274_BIRC2_chr11_102233627_ENST00000532672_length(amino acids)=477AA_BP=0
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK
LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMA
KTSSGQRYFLKCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQ
TVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQ
IPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVV

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:102221674/chr11:102033187)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	BIRC2 Q13490
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. {ECO:0000269\|PubMed:15665297, ECO:0000269\|PubMed:18082613, ECO:0000269\|PubMed:21145488, ECO:0000269\|PubMed:21653699, ECO:0000269\|PubMed:21931591, ECO:0000269\|PubMed:23453969}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000282441

86_100

190.66666666666666

505.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000345877

86_100

190.66666666666666

455.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000526343

86_100

190.66666666666666

451.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000531439

86_100

190.66666666666666

489.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000537274

86_100

190.66666666666666

493.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000282441

86_100

190.66666666666666

505.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000345877

86_100

190.66666666666666

455.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000526343

86_100

190.66666666666666

451.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000531439

86_100

190.66666666666666

489.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000537274

86_100

190.66666666666666

493.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000282441

86_100

190.66666666666666

505.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000345877

86_100

190.66666666666666

455.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000526343

86_100

190.66666666666666

451.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000531439

86_100

190.66666666666666

489.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000537274

86_100

190.66666666666666

493.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000282441

3_49

190.66666666666666

505.0

Compositional bias

Note=Pro-rich

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000345877

3_49

190.66666666666666

455.0

Compositional bias

Note=Pro-rich

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000526343

3_49

190.66666666666666

451.0

Compositional bias

Note=Pro-rich

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000531439

3_49

190.66666666666666

489.0

Compositional bias

Note=Pro-rich

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000537274

3_49

190.66666666666666

493.0

Compositional bias

Note=Pro-rich

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000282441

3_49

190.66666666666666

505.0

Compositional bias

Note=Pro-rich

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000345877

3_49

190.66666666666666

455.0

Compositional bias

Note=Pro-rich

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000526343

3_49

190.66666666666666

451.0

Compositional bias

Note=Pro-rich

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000531439

3_49

190.66666666666666

489.0

Compositional bias

Note=Pro-rich

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000537274

3_49

190.66666666666666

493.0

Compositional bias

Note=Pro-rich

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000282441

3_49

190.66666666666666

505.0

Compositional bias

Note=Pro-rich

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000345877

3_49

190.66666666666666

455.0

Compositional bias

Note=Pro-rich

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000526343

3_49

190.66666666666666

451.0

Compositional bias

Note=Pro-rich

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000531439

3_49

190.66666666666666

489.0

Compositional bias

Note=Pro-rich

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000537274

3_49

190.66666666666666

493.0

Compositional bias

Note=Pro-rich

Tgene

BIRC2

chr11:101985124

chr11:102233626

ENST00000227758

453_543

331.6666666666667

619.0

Domain

CARD

Tgene

BIRC2

chr11:101985124

chr11:102233626

ENST00000530675

453_543

282.6666666666667

570.0

Domain

CARD

Tgene

BIRC2

chr11:101985125

chr11:102233626

ENST00000227758

453_543

331.6666666666667

619.0

Domain

CARD

Tgene

BIRC2

chr11:101985125

chr11:102233626

ENST00000530675

453_543

282.6666666666667

570.0

Domain

CARD

Tgene

BIRC2

chr11:101985125

chr11:102233627

ENST00000227758

453_543

331.6666666666667

619.0

Domain

CARD

Tgene

BIRC2

chr11:101985125

chr11:102233627

ENST00000530675

453_543

282.6666666666667

570.0

Domain

CARD

Tgene

BIRC2

chr11:101985124

chr11:102233626

ENST00000227758

571_606

331.6666666666667

619.0

Zinc finger

RING-type

Tgene

BIRC2

chr11:101985124

chr11:102233626

ENST00000530675

571_606

282.6666666666667

570.0

Zinc finger

RING-type

Tgene

BIRC2

chr11:101985125

chr11:102233626

ENST00000227758

571_606

331.6666666666667

619.0

Zinc finger

RING-type

Tgene

BIRC2

chr11:101985125

chr11:102233626

ENST00000530675

571_606

282.6666666666667

570.0

Zinc finger

RING-type

Tgene

BIRC2

chr11:101985125

chr11:102233627

ENST00000227758

571_606

331.6666666666667

619.0

Zinc finger

RING-type

Tgene

BIRC2

chr11:101985125

chr11:102233627

ENST00000530675

571_606

282.6666666666667

570.0

Zinc finger

RING-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000282441

298_359

190.66666666666666

505.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000345877

298_359

190.66666666666666

455.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000524575

298_359

12.666666666666666

327.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000524575

86_100

12.666666666666666

327.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000526343

298_359

190.66666666666666

451.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000531439

298_359

190.66666666666666

489.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000537274

298_359

190.66666666666666

493.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000282441

298_359

190.66666666666666

505.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000345877

298_359

190.66666666666666

455.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000524575

298_359

12.666666666666666

327.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000524575

86_100

12.666666666666666

327.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000526343

298_359

190.66666666666666

451.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000531439

298_359

190.66666666666666

489.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000537274

298_359

190.66666666666666

493.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000282441

298_359

190.66666666666666

505.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000345877

298_359

190.66666666666666

455.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000524575

298_359

12.666666666666666

327.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000524575

86_100

12.666666666666666

327.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000526343

298_359

190.66666666666666

451.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000531439

298_359

190.66666666666666

489.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000537274

298_359

190.66666666666666

493.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000524575

3_49

12.666666666666666

327.0

Compositional bias

Note=Pro-rich

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000524575

3_49

12.666666666666666

327.0

Compositional bias

Note=Pro-rich

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000524575

3_49

12.666666666666666

327.0

Compositional bias

Note=Pro-rich

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000282441

171_204

190.66666666666666

505.0

Domain

WW 1

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000282441

230_263

190.66666666666666

505.0

Domain

WW 2

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000345877

171_204

190.66666666666666

455.0

Domain

WW 1

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000345877

230_263

190.66666666666666

455.0

Domain

WW 2

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000524575

171_204

12.666666666666666

327.0

Domain

WW 1

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000524575

230_263

12.666666666666666

327.0

Domain

WW 2

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000526343

171_204

190.66666666666666

451.0

Domain

WW 1

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000526343

230_263

190.66666666666666

451.0

Domain

WW 2

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000531439

171_204

190.66666666666666

489.0

Domain

WW 1

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000531439

230_263

190.66666666666666

489.0

Domain

WW 2

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000537274

171_204

190.66666666666666

493.0

Domain

WW 1

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000537274

230_263

190.66666666666666

493.0

Domain

WW 2

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000282441

171_204

190.66666666666666

505.0

Domain

WW 1

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000282441

230_263

190.66666666666666

505.0

Domain

WW 2

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000345877

171_204

190.66666666666666

455.0

Domain

WW 1

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000345877

230_263

190.66666666666666

455.0

Domain

WW 2

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000524575

171_204

12.666666666666666

327.0

Domain

WW 1

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000524575

230_263

12.666666666666666

327.0

Domain

WW 2

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000526343

171_204

190.66666666666666

451.0

Domain

WW 1

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000526343

230_263

190.66666666666666

451.0

Domain

WW 2

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000531439

171_204

190.66666666666666

489.0

Domain

WW 1

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000531439

230_263

190.66666666666666

489.0

Domain

WW 2

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000537274

171_204

190.66666666666666

493.0

Domain

WW 1

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000537274

230_263

190.66666666666666

493.0

Domain

WW 2

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000282441

171_204

190.66666666666666

505.0

Domain

WW 1

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000282441

230_263

190.66666666666666

505.0

Domain

WW 2

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000345877

171_204

190.66666666666666

455.0

Domain

WW 1

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000345877

230_263

190.66666666666666

455.0

Domain

WW 2

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000524575

171_204

12.666666666666666

327.0

Domain

WW 1

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000524575

230_263

12.666666666666666

327.0

Domain

WW 2

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000526343

171_204

190.66666666666666

451.0

Domain

WW 1

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000526343

230_263

190.66666666666666

451.0

Domain

WW 2

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000531439

171_204

190.66666666666666

489.0

Domain

WW 1

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000531439

230_263

190.66666666666666

489.0

Domain

WW 2

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000537274

171_204

190.66666666666666

493.0

Domain

WW 1

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000537274

230_263

190.66666666666666

493.0

Domain

WW 2

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000282441

291_504

190.66666666666666

505.0

Region

Note=Transactivation domain

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000345877

291_504

190.66666666666666

455.0

Region

Note=Transactivation domain

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000524575

291_504

12.666666666666666

327.0

Region

Note=Transactivation domain

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000526343

291_504

190.66666666666666

451.0

Region

Note=Transactivation domain

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000531439

291_504

190.66666666666666

489.0

Region

Note=Transactivation domain

Hgene

YAP1

chr11:101985124

chr11:102233626

ENST00000537274

291_504

190.66666666666666

493.0

Region

Note=Transactivation domain

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000282441

291_504

190.66666666666666

505.0

Region

Note=Transactivation domain

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000345877

291_504

190.66666666666666

455.0

Region

Note=Transactivation domain

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000524575

291_504

12.666666666666666

327.0

Region

Note=Transactivation domain

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000526343

291_504

190.66666666666666

451.0

Region

Note=Transactivation domain

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000531439

291_504

190.66666666666666

489.0

Region

Note=Transactivation domain

Hgene

YAP1

chr11:101985125

chr11:102233626

ENST00000537274

291_504

190.66666666666666

493.0

Region

Note=Transactivation domain

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000282441

291_504

190.66666666666666

505.0

Region

Note=Transactivation domain

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000345877

291_504

190.66666666666666

455.0

Region

Note=Transactivation domain

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000524575

291_504

12.666666666666666

327.0

Region

Note=Transactivation domain

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000526343

291_504

190.66666666666666

451.0

Region

Note=Transactivation domain

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000531439

291_504

190.66666666666666

489.0

Region

Note=Transactivation domain

Hgene

YAP1

chr11:101985125

chr11:102233627

ENST00000537274

291_504

190.66666666666666

493.0

Region

Note=Transactivation domain

Tgene

BIRC2

chr11:101985124

chr11:102233626

ENST00000227758

184_250

331.6666666666667

619.0

Repeat

Note=BIR 2

Tgene

BIRC2

chr11:101985124

chr11:102233626

ENST00000227758

269_336

331.6666666666667

619.0

Repeat

Note=BIR 3

Tgene

BIRC2

chr11:101985124

chr11:102233626

ENST00000227758

46_113

331.6666666666667

619.0

Repeat

Note=BIR 1

Tgene

BIRC2

chr11:101985124

chr11:102233626

ENST00000530675

184_250

282.6666666666667

570.0

Repeat

Note=BIR 2

Tgene

BIRC2

chr11:101985124

chr11:102233626

ENST00000530675

269_336

282.6666666666667

570.0

Repeat

Note=BIR 3

Tgene

BIRC2

chr11:101985124

chr11:102233626

ENST00000530675

46_113

282.6666666666667

570.0

Repeat

Note=BIR 1

Tgene

BIRC2

chr11:101985125

chr11:102233626

ENST00000227758

184_250

331.6666666666667

619.0

Repeat

Note=BIR 2

Tgene

BIRC2

chr11:101985125

chr11:102233626

ENST00000227758

269_336

331.6666666666667

619.0

Repeat

Note=BIR 3

Tgene

BIRC2

chr11:101985125

chr11:102233626

ENST00000227758

46_113

331.6666666666667

619.0

Repeat

Note=BIR 1

Tgene

BIRC2

chr11:101985125

chr11:102233626

ENST00000530675

184_250

282.6666666666667

570.0

Repeat

Note=BIR 2

Tgene

BIRC2

chr11:101985125

chr11:102233626

ENST00000530675

269_336

282.6666666666667

570.0

Repeat

Note=BIR 3

Tgene

BIRC2

chr11:101985125

chr11:102233626

ENST00000530675

46_113

282.6666666666667

570.0

Repeat

Note=BIR 1

Tgene

BIRC2

chr11:101985125

chr11:102233627

ENST00000227758

184_250

331.6666666666667

619.0

Repeat

Note=BIR 2

Tgene

BIRC2

chr11:101985125

chr11:102233627

ENST00000227758

269_336

331.6666666666667

619.0

Repeat

Note=BIR 3

Tgene

BIRC2

chr11:101985125

chr11:102233627

ENST00000227758

46_113

331.6666666666667

619.0

Repeat

Note=BIR 1

Tgene

BIRC2

chr11:101985125

chr11:102233627

ENST00000530675

184_250

282.6666666666667

570.0

Repeat

Note=BIR 2

Tgene

BIRC2

chr11:101985125

chr11:102233627

ENST00000530675

269_336

282.6666666666667

570.0

Repeat

Note=BIR 3

Tgene

BIRC2

chr11:101985125

chr11:102233627

ENST00000530675

46_113

282.6666666666667

570.0

Repeat

Note=BIR 1

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
YAP1
BIRC2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to YAP1-BIRC2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to YAP1-BIRC2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source